JPOST Repositoryapplication/xmlhttps://storage.jpostdb.org/JPST003773/files/report.pg_matrix.tsvhttps://storage.jpostdb.org/JPST003773/files/report.log.txthttps://storage.jpostdb.org/JPST003773/files/cisR3.d.ziphttps://storage.jpostdb.org/JPST003773/files/cisS1.d.ziphttps://storage.jpostdb.org/JPST003773/files/cisS2.d.ziphttps://storage.jpostdb.org/JPST003773/files/cisR2.d.ziphttps://storage.jpostdb.org/JPST003773/files/cis_QCPool1.d.ziphttps://storage.jpostdb.org/JPST003773/files/cisR1.d.ziphttps://storage.jpostdb.org/JPST003773/files/cisS3.d.ziphttps://storage.jpostdb.org/JPST003773/files/cis_QCPool2.d.zipprimaryOK200ProteomicsProf. Sanjeeva SrivastavaHomo Sapiens (human)https://repository.jpostdb.org/entry/JPST003773IIT BombayjPOSTfalseTimsTOF-Based DIA Proteomic Profiling of Cisplatin-Resistant and Sensitive MDA-MB-231 Triple-Negative Breast Cancer Cell LinesThis dataset presents data-independent acquisition (DIA)-based proteomic profiles generated using a timsTOF Pro mass spectrometer for cisplatin-resistant (cisR) and cisplatin-sensitive (cisS) MDA-MB-231 triple-negative breast cancer (TNBC) cell lines. The objective was to decipher proteomic alterations associated with cisplatin resistance. The analysis uncovered significant upregulation of extracellular matrix (ECM) remodeling proteins (e.g., COL6A1, COL6A2, COL6A3), and invasion-related membrane proteins (e.g., TIMP1, MMP-14, APP) in cisR cells. The dataset offers high-resolution, reproducible proteomic insights into the mechanisms of cisplatin resistance, emphasizing the role of EMT, metabolic reprogramming, and membrane remodeling in TNBC.Wed Apr 22 00:00:00 BST 2026PXD0631759606