JPOST Repositoryapplication/xmlhttps://storage.jpostdb.org/JPST003922/files/I230613_53.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_38.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_23.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_21.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_88.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_40.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_71.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_70.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_86.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_05.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_56.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_24.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_54.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_22.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_69.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_39.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_85.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_72.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_87.rawhttps://storage.jpostdb.org/JPST003922/files/I230613_55.rawprimaryOK200ProteomicsJürgen FritschHomo Sapiens (human)https://repository.jpostdb.org/entry/JPST003922Insitute of Immunology, University Medical Center MainzjPOSTfalseLoss of ADAM15 prevents necroptosis induction by partial RIPK1 degradation and altered organelle organization.Death receptor-mediated signaling pathways must be tightly regulated to ensure tissue homeostasis. In a previous study, ADAM15 was identified as a possible TNF-regulated protease. We here unveil ADAM15 as a regulator of TNF-mediated necroptosis, while apoptosis and survival pathways remain unaffected. ADAM15 knockout results in the modulation of death-associated proteins and protein networks. Using a bottom-up proteomics screen to compare human U937 wild-type and ADAM15 knockdown cells enabled us to identify proteins and networks affected by ADAM15 loss, and which may be involved in necroptosis regulation.Sat Jul 11 00:00:00 GMT+01:00 2026PXD0660569606