{"database":"JPOST Repository","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Wiff":["https://storage.jpostdb.org/JPST003949/files/Caco2_TP1_1_IDA1.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_control1_SWATH2.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_control3_SWATH2.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_control3_SWATH1.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_TP1_1_IDA2.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_control2_SWATH1.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_control2_IDA2.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_control2_IDA1.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_TP1_2_SWATH1.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_control3_IDA1.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_TP1_2_IDA1.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_control1_IDA1.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_TP1_2_SWATH2.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_control3_IDA2.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_control2_SWATH2.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_TP1_2_IDA2.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_TP1_1_SWATH1.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_TP1_1_SWATH2.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_control1_SWATH1.wiff.scan","https://storage.jpostdb.org/JPST003949/files/Caco2_control1_IDA2.wiff.scan"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Chutima S. Vaddhanaphuti"],"species":["Homo Sapiens (human)"],"full_dataset_link":["https://repository.jpostdb.org/entry/JPST003949"],"submitter_affiliation":["Mahidol University"],"sample_protocol":[""],"repository":["jPOST"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Understanding the Mechanisms of Asperidine B, a Preussin Derivative, on the Inhibition of Intestinal Cholesterol Absorption Mediated by Tight Junction Function","description":"â€¢ Preussin derivatives, asperidine B and its desmethyl analogue, exerted antioxidative and lipid-lowering effects similarly to their parent compound. \nâ€¢ Asperidine B had higher potency by lowering cholesterol level than its methyl analogue in both ex vivo isolated jejunal epithelium, and in vivo models. \nâ€¢ Asperidine B upregulated Î±-catenin and EpCAM proteins by proteomics approach, which they are relevance in tight junction integrity. \nâ€¢ Asperidine B strongly inhibited intestinal cholesterol absorption by directly interaction  with ZO-1 protein function and expression.","dates":{"publication":"Sat Jul 18 00:00:00 BST 2026"},"accession":"PXD066299","cross_references":{"TAXONOMY":["9606"]}}