JPOST Repositoryapplication/xmlhttps://storage.jpostdb.org/JPST003949/files/Caco2_TP1_1_IDA1.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_control1_SWATH2.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_control3_SWATH2.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_control3_SWATH1.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_TP1_1_IDA2.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_control2_SWATH1.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_control2_IDA2.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_control2_IDA1.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_TP1_2_SWATH1.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_control3_IDA1.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_TP1_2_IDA1.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_control1_IDA1.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_TP1_2_SWATH2.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_control3_IDA2.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_control2_SWATH2.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_TP1_2_IDA2.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_TP1_1_SWATH1.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_TP1_1_SWATH2.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_control1_SWATH1.wiff.scanhttps://storage.jpostdb.org/JPST003949/files/Caco2_control1_IDA2.wiff.scanprimaryOK200ProteomicsChutima S. VaddhanaphutiHomo Sapiens (human)https://repository.jpostdb.org/entry/JPST003949Mahidol UniversityjPOSTfalseUnderstanding the Mechanisms of Asperidine B, a Preussin Derivative, on the Inhibition of Intestinal Cholesterol Absorption Mediated by Tight Junction Function• Preussin derivatives, asperidine B and its desmethyl analogue, exerted antioxidative and lipid-lowering effects similarly to their parent compound. • Asperidine B had higher potency by lowering cholesterol level than its methyl analogue in both ex vivo isolated jejunal epithelium, and in vivo models. • Asperidine B upregulated α-catenin and EpCAM proteins by proteomics approach, which they are relevance in tight junction integrity. • Asperidine B strongly inhibited intestinal cholesterol absorption by directly interaction with ZO-1 protein function and expression.Sat Jul 18 00:00:00 BST 2026PXD0662999606