JPOST Repositoryapplication/xmlhttps://storage.jpostdb.org/JPST003953/files/Supplementary_Group3.xlsxhttps://storage.jpostdb.org/JPST003953/files/IPA_Report_Cpd3.xlsxhttps://storage.jpostdb.org/JPST003953/files/IPA_ReportSummary.pdfhttps://storage.jpostdb.org/JPST003953/files/250110_USYD_MF_015_16.wiff.scanhttps://storage.jpostdb.org/JPST003953/files/250110_USYD_MF_018_II.wiff.scanhttps://storage.jpostdb.org/JPST003953/files/250110_USYD_MF_017_II.wiff.scanhttps://storage.jpostdb.org/JPST003953/files/250110_USYD_MF_017_II.wiffhttps://storage.jpostdb.org/JPST003953/files/250110_USYD_MF_016.wiffhttps://storage.jpostdb.org/JPST003953/files/250110_USYD_MF_018_II.wiffhttps://storage.jpostdb.org/JPST003953/files/250110_USYD_MF_015.wiff.scanhttps://storage.jpostdb.org/JPST003953/files/250110_USYD_MF_016.wiff.scanhttps://storage.jpostdb.org/JPST003953/files/250110_USYD_MF_015_16.wiffhttps://storage.jpostdb.org/JPST003953/files/250110_USYD_MF_017_18_II.wiff.scanhttps://storage.jpostdb.org/JPST003953/files/250110_USYD_MF_017_18_II.wiffhttps://storage.jpostdb.org/JPST003953/files/250110_USYD_MF_015.wiffhttps://storage.jpostdb.org/JPST003953/files/20250113_092126_250110_USYD_MF_CVRN%20-GroupIII.sneprimaryOK200ProteomicsMohamed MetwalyHomo Sapiens (human)https://repository.jpostdb.org/entry/JPST003953Faculty of Pharmacy Cairo University, Victor Chang Cardiac Research InstitutejPOSTfalseMechanistic insights into the anticancer effect of pyridopyrimidine derivatives in Gastric AdenocarcinomaThis study presents the design, synthesis, and in vitro evaluation of novel pyridopyrimidine derivatives as potential anticancer agents against gastric cancer. Several compounds showed strong cytotoxic and selective antiproliferative effects in AGS cells. To uncover the mode of action of representative compound, label-free quantitative proteomics was performed, revealing key alterations in proteins linked to various spotted pathways as indicated in IPA analysis.Mon Jul 20 00:00:00 BST 2026PXD0663309606