{"database":"JPOST Repository","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Tabular":["https://storage.jpostdb.org/JPST004748/files/PK25002.tsv","https://storage.jpostdb.org/JPST004748/files/PK25002.pr_matrix.tsv","https://storage.jpostdb.org/JPST004748/files/PK25002.pg_matrix.tsv","https://storage.jpostdb.org/JPST004748/files/PK25002.gg_matrix.tsv"],"Raw":["https://storage.jpostdb.org/JPST004748/files/PK25002-02_2_K562_Coffee_rep1.raw","https://storage.jpostdb.org/JPST004748/files/PK25002-03_3_K562_None_rep2.raw","https://storage.jpostdb.org/JPST004748/files/PK25002-01_1_K562_None_rep1.raw","https://storage.jpostdb.org/JPST004748/files/PK25002-03_4_K562_Coffee_rep2.raw"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Kazumasa Aoyama"],"species":["Homo Sapiens (human)"],"full_dataset_link":["https://repository.jpostdb.org/entry/JPST004748"],"submitter_affiliation":["Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University"],"sample_protocol":[""],"repository":["jPOST"],"data_protocol":[""],"additional_accession":[]},"is_claimable":false,"name":"Coffee remodels the histone acetylation landscape in association with suppression of the MYC transcriptional program","description":"This dataset contains data-independent acquisition (DIA) proteomics data generated from K562 human leukemia cells treated with coffee extract or vehicle control. Quantitative proteomic analysis was performed to investigate molecular mechanisms underlying coffee-induced epigenetic remodeling. The proteomics dataset was integrated with histone modification profiling, ChIP-seq and RNA-seq analyses to characterize pathways associated with histone acetylation and MYC transcriptional regulation.","dates":{"publication":"Wed Jul 08 00:00:00 BST 2026"},"accession":"PXD080702","cross_references":{"TAXONOMY":["9606"]}}