{"database":"JPOST Repository","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["https://storage.jpostdb.org/JPST002750/files/rawfiles.txt","https://storage.jpostdb.org/JPST002750/files/mai100616_014FGR.txt","https://storage.jpostdb.org/JPST002750/files/mai100616_014FGR.maxq.txt"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Proteomics"],"submitter":["Yasushi Ishihama"],"species":["Homo Sapiens (human)"],"full_dataset_link":["https://repository.jpostdb.org/entry/JPST002750"],"submitter_affiliation":["jPOST"],"sample_protocol":[""],"repository":["jPOST"],"data_protocol":[""],"name_synonyms":["scale tissue, human being, 249 grams, acetylglucosaminyltransferase-like protein, FET GROWTH RET 750-999G, peltate hair, Mbp1, Poor fetal growth state, LARGE1, froggy, Gyltl1a, Human, FET GROWTH RETARD <500G, unspecified, Homo sapiens, 750-1, 999 grams, FET GROWTH RETARD WTNOS, FET GRWTH RET 1250-1499G, 1, 2, intrauterine Growth restriction, IUGR, fetal SGA, myd, Man, FET GRWTH RET 1000-1249G, Intrauterine growth retardation, Man (Taxonomy), like-acetylglucosaminyltransferase, FET GRWTH RET 1500-1749G, Fetal growth retardation NOS (disorder), MDDGB6, Fetal growth retardation (disorder), plant peltate hair, Mbp-1, fetal growth restriction, LARGE, fetal Growth retardation., 500-1, fetal growth retardation, 500+ grams, Fetal growth retardation NOS, Poor fetal growth, FGR - Fetal growth retardation, p55-Fgr, BPFD#36, intrauterine Growth retardation, c-src2, fetus small for gestational Age, 250-1, 500-749 grams, 000-1, 000-2, p55c-fgr, p58c-fgr, Fetal growth retardation, FET GRWTH RET 1750-1999G, less than 500 grams, foetal Growth retardation, gyltl1b-b, Modern, foetal SGA, unspecified [weight], p58-Fgr, Fetal Growth Retardation, MDDGA6, mKIAA0609, FGR, foetal small for gestational Age, NOS, scales, KIAA0609, acetylglucosaminyltransferase-like 1A, fg, gyltl1b, SRC2, FET GROWTH RET 500-749G, fetal small for gestational Age, scale, FET GROWTH RET 2500+G, Microsomic baby, mdc1d, IUGR - Intrauterine growth retardation, foetal growth retardation, LARGE_HUMAN, human, MDC1D, like-glycosyltransferase, enr, foetus small for gestational Age, 750-999 grams, Modern Man, c-fgr, Microsomia, Foetal growth retardation, FET GRWTH RET 2000-2499G, 749 grams, 499 grams, glycosyltransferase-like protein LARGE1"],"description_synonyms":["Signal Transduction Systems, Signal Transductions, para Tyrosine, human being, Peptidomics, Receptor-Mediated, number, Signal Transduction System, L-Threonine, presence, Migrant Workers, Human, 2-Amino-3-hydroxypropionic acid, Receptor Mediated Signal Transduction, Signal Transduction, Homo sapiens, Kinase, Cell Signaling, Man, Phosphotransferase, Threonin, signal transduction by protein phosphorylation, Man (Taxonomy), Migrant Worker, Transients, 2-amino-3-(4-hydroxyphenyl)propanoic acid, 3-(p-Hydroxyphenyl)alanine, Nonmigrant, Signal, Pathways, Nonmigrants, Signal Pathways, L Threonine, Transphosphorylase, Worker, Y, Signal Transduction Pathway, Transient, project description., Squatter, set, signalling pathway, 2-amino-3-hydroxypropanoic acid, L Tyrosine, grupos, Tyr, Squatters, signal transduction by cis-phosphorylation, Signal Transduction Pathways, Transductions, Tyrosin, ATP Phosphotransferases, Signal Pathway, ATP, single organism signaling, Pathway, grupo, Modern, 2-Amino-3-(p-hydroxyphenyl)propionic acid, signal transduction by conformational transition, Receptor-Mediated Signal Transductions, total expressed protein, para-Tyrosine, Phosphotransferases, signal transduction by trans-phosphorylation, group, Tyrosine, signaling cascade, count in organism, Serin, 3-Hydroxyalanine, tirosina, Receptor-Mediated Signal Transduction, Migrant, Systems, Nomad, Workers, signalling cascade, Transduction, Migrants and Transients, Transphosphorylases, ensemble, Kinases, System, L-isomer, Rest, human, L isomer, signaling pathway, signalling process, Modern Man, Nomads, Migrants, L Serine, L-Tyrosine, L-Serine, Proteomes, groupe, Gruppe"],"additional_accession":[]},"is_claimable":false,"name":"Large-scale Discovery of Substrates of the Human Kinome (FGR) [Reanalysis: JPST000508]","description":"Kinase -networks are important for cellular signal transduction. Despite tremendous efforts to uncover these signaling pathways, huge numbers of uncharacterized phosphosites still remain in the human proteome. Because of the transient nature of kinase-substrate interactions in vivo, it is almost impossible to identify direct substrates. Here, we present a novel strategy for the rapid and high-throughput discovery for of kinase substrates of kinase using quantitative proteomics. Using 385 purified kinases, we identified a total of 175,574 potential direct kinase substrates of kinases. In addition, we identified novel kinase groups, such as one group containing 30 threonine-directed kinases and another containing 15 serine/threonine/tyrosine kinase sgroup. Surprisingly, we observed that the diversity of substrates for tyrosine kinases was much higher than that for serine-threonine kinases. [Original project description]","dates":{"publication":"Wed Feb 21 00:00:00 GMT 2024"},"accession":"RPXD049761","cross_references":{"TAXONOMY":["9606"]}}