{"database":"MassIVE","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://massive-ftp.ucsd.edu/x01/MSV000079991/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":0,"searchCount":0},"additional":{"omics_type":["Proteomics"],"submitter":["Dr Jean Armengaud"],"instrument_platform":["LTQ Orbitrap"],"species":["Homo Sapiens (ncbitaxon:9606)"],"full_dataset_link":["https://massive.ucsd.edu/ProteoSAFe/dataset.jsp?task=8af9cd55a9e845a6acb585ce81653331"],"sample_protocol":[""],"repository":["MassIVE"],"file_size":["15"],"ptm_modification":["UNIMOD:4 - \"Iodoacetamide derivative.\"","UNIMOD:35 - \"Oxidation or Hydroxylation.\""],"data_protocol":[""],"pubmed_abstract":["Sexual reproduction is crucially dependent on meiosis, a conserved, specialized cell division programme that is essential for the production of haploid gametes. Here we demonstrate that fertility and the implementation of the meiotic programme require a previously uncharacterized meiosis-specific protein, MEIOC. Meioc invalidation in mice induces early and pleiotropic meiotic defects in males and females. MEIOC prevents meiotic transcript degradation and interacts with an RNA helicase that binds numerous meiotic mRNAs. Our results indicate that proper engagement into meiosis necessitates the specific stabilization of meiotic transcripts, a previously little-appreciated feature in mammals. Remarkably, the upregulation of MEIOC at the onset of meiosis does not require retinoic acid and STRA8 signalling. Thus, we propose that the complete induction of the meiotic programme requires both retinoic acid-dependent and -independent mechanisms. The latter process involving post-transcriptional regulation likely represents an ancestral mechanism, given that MEIOC homologues are conserved throughout multicellular animals."],"pubmed_title":["Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts.","The place of analytical chemistry in clinical pharmacology."],"pubmed_authors":["Abby Emilie E, Tourpin Sophie S, Ribeiro Jonathan J, Daniel Katrin K, Messiaen Sébastien S, Moison Delphine D, Guerquin Justine J, Gaillard Jean-Charles JC, Armengaud Jean J, Langa Francina F, Toth Attila A, Martini Emmanuelle E, Livera Gabriel G","Tsikas Dimitrios D"],"pubmed_abstract_synonyms":["biochemical pathways, single-organism catabolic process, multicellular organismal catabolic process, Ghrfr, Tretin M, Laboratory, Refissa, Feature, Mus domesticus, metazoans, Phases, CASP-14, protein, congenital defects, House Mouse, Divisions, aplasia, Social Controls, World Fertility Survey, Retinoic Acid, Fertility Preferences, protein polypeptide chains, Below Replacement, Cordes vas, cellular degradation, 3, 4, 6, protein aggregate, Fs(3)Hor, Microeconomic, Formal Social Controls, Fertility Surveys, Retinoic acid, Retinoic, Animalia, Fertility Incentives, Theory, DmelCG2684, Utility Theories, M Phases, all-trans-beta-Retinoic acid, Household Consumption, Natural, catabolism, M, Salt, Economic Policies, hypoplasia, Age of onset, Swiss Mice, proteins, Tretinoin Potassium Salt, Betarretin, Living Costs, 8E)-3, NTef2, trans Retinoic Acid, Germ-Line, 6-trimethyl-1-cyclohexenyl)nona-2, Social, Division Phase, signaling process, Fertility Determinant, Fertility Preference, Household Consumptions, biotransformation, Economic, Theories, Haploid, Vitamin A Acid, Haploidies, Differential Fertility, (2E, single organism signaling, Home Economics, anatomical protrusion, Indices, Index, Meiotic M Phase, Hypothesis, World Fertility Surveys, mouse, 4E, Up-Regulation (Physiology), Germ-Line Cell, lit, Cell Divisions, Ro 1-5488, INSDC_feature:misc_RNA, deformities, Macroeconomic Factors, Fs(3)Sz11, trans-retinoic acid, Economics, all-trans retinoic acid, Economic Condition, RNA HELICASE, 8-nonatetraenoic acid, Household, all-trans-vitamin A acid, Biacna, 6-trimethylcyclohex-1-enyl)nona-2, Utility Theory, Retin A, Mini-ICE, Gamete, Germ Cell, retinoic acid, secretion, all-trans-tretinoin, Macroeconomic, all-trans-Retinoic, Meiotic M Phases, little, atresia, Mus musculus, Acid, tretinoina, Factors, breakdown, Caspase-14 subunit p10, Upregulation, mice, 6E, Consumer Price Indices, Swiss Mouse, malformations, Control, beta-all-trans-Retinoic Acid, tretinoinum, Caspase-14 subunit p19, 6-trimethylcyclohexen-1-yl)nona-2E, Controls, MICE, Features, Haploid Cell, Preferences, Home, early, Fertility Determinants, domesticus, Condition, Zinc Salt, Sodium Salt, 7-dimethyl-9-(2, Easterlin Hypothesis, all-(E)-retinoic acid, spine, Horka, anomalies, Cells, Surveys, CG2684, Fs(3)Horka, Mammalia, Mouse, (all-E)-3, 8-tetraenoic acid, Fecundability, tretinoine, Regulation, Remittances, Marital Fertility, Regulations, 3.4.22.-, meiosis, Policies, Subfecundity, biological signaling, tretinoin, trans-Retinoic Acid, Vitamin A, Utility, Gene, Fertility, mini-ICE, 8E-tetraenoic acid, protein-containing complex, beta all trans Retinoic Acid, cellular catabolism, Germ Lines, 6-trimethyl-1-cyclohexen-1-yl)-2, Easterlin, AGN 100335, protrusion, Potassium Salt, Germ Line, Determinant, polypeptide chain, House, Helicases, Gene Products, Mus musculus domesticus, Germ Line Cells, Survey, mammals, Preference, DmF2, World Fertility, Retin-A, defects, Mice, Vesanoid, Stieva-A, 6-trimethylcyclohex-1-en-1-yl)nona-2, Fecundity, Gametes, lod, Cell Division Phase, breakdown of chemical, Swiss, Receptor Up-Regulation, Up Regulation, Renova, all trans Retinoic Acid, Atralin, Microeconomic Factors, Meioses, Cell Division, Economic Conditions, Division, Tretinoin Sodium Salt, Meiotic, beta-all-trans-Retinoic, Altreno, Capital, Below Replacement Fertility, Fertility Incentive, Characteristics, trans-Retinoic, Veltin, Policy, all-trans-vitamin A1 acid, Economic Policy, Haploid Cells, cellular breakdown, RNA, degradation, Formal Social Control, World, protein complex, Males, Tretinoin Zinc Salt, animals., Conditions, 8-all-trans-tetraenoic acid, Proteins, Mammal, Factor, Production, Germ, Dermairol, Tretinoin Potassium, Living Cost, Cell, Tri-luma, Tretinoin, Consumption, all-trans-Retinoic Acid, Tretinoin Sodium, MMI9_2, Characteristic, native protein, Consumer Price Index, natural protein, Consumer Price, Mus, Social Control, agenesis, Protein, MMI9.2, Natural Fertility, Determinants, 6-trimethyl-1-cyclohexene-1-yl)-2, M Phase, Acide retinoique (French), breakdown of molecule, beta-Retinoic acid, Germ-Line Cells, Phase, Meiotic M, biodegradation, Tretinoin Zinc, House Mice, Age symptoms begin, Lds, signalling, Laboratory Mice, Protein Gene Products, Helicase, multicellular animals, Gene Proteins, Differential, breakdown of substance, Remittance, signalling process, Marital, Avita, Haploids, Cost of Living, birth defects, vitamin A acid, RNA Helicase, regulation, Retisol-A, Laboratory Mouse, Females, Fertility Survey"],"description_synonyms":["Immune Precipitations, Co Immunoprecipitation, Peptidomics., Co-Immunoprecipitations, Precipitation, Immune, Precipitations, Immune Precipitation, Co-Immunoprecipitation"],"pubmed_title_synonyms":["meiosis, Phase, Meiotic M, Diplonemas, Diakinesis, M Phases, Leptotene Stage, Meiotic M Phase, Retinoid., Prophase 1, Phases, Meioses, Stage, Diakineses, Zygonema, Diplonema, Meiotic, Zygotene Stage, Zygonemas, Stages, Zygotene Stages, Diplotene, M Phase, Prophase I, Diplotene Stage, Leptotene, Meiotic M Phases, Zygotene, Meiotic Prophase 1"],"name_synonyms":["Characterization, Characterized."],"citation_count":["0"],"additional_accession":["PXD003200"]},"is_claimable":true,"name":"Proteomic characterization of MEIOC interactants: part 2","description":"Identification of MEIOC interactants by immunoprecipitation and shotgun proteomics","dates":{"publication":"Fri Jul 22 16:06:00 BST 2016"},"accession":"MSV000079991","cross_references":{"pubmed":["26742488"]}}