MassIVEapplication/xmlftp://massive.ucsd.edu/v03/MSV000086762/primaryOK200Prof. Xuechen Lihttps://massive.ucsd.edu/ProteoSAFe/dataset.jsp?task=f621f08e08f7420b94ebc0edae07cec0xuechenl@hku.hkMassIVE3,265[K, C, Y, R, D, E, H, M, N, O, Q, S, T, U, W], [510, 281200677587]ProteomicsOrbitrap FusionHomo Sapiens (ncbitaxon:9606)The University of Hong Kongsodium salt, hydrogen bromide, para Tyrosine, chemical properties, chemical characterization, hydrogen, monopyridine phosphate, pyridine cyanate, Proteins, 2-Amino-3-(p-hydroxyphenyl)propionic acid, Gene, pyridine disulfate, para-Tyrosine, pyridine phosphate, pyridine ion (1-), Tyrosine, pyridine sulfate (2:1), pyridine ion (2+), potassium salt, pyridine, tirosina, Protein, pyridine hydride (2:1), Gene Products, pyridine sulfate, pyridine monophosphate, tyrosine, pyridine phosphate (2:1), pyridine diphosphate, pyridine dinitrate, hydrogen fluoride, pyridine nitrate, Protein., pyridine monohydrate, 2-amino-3-(4-hydroxyphenyl)propanoic acid, 3-(p-Hydroxyphenyl)alanine, L-isomer, pyridine monosulfate, hydrogen iodide, labeling, proteins, chemical content, Y, pyridine perchlorate, L isomer, Protein Gene Products, pyridine hydride, Gene Proteins, lithium salt, L Tyrosine, Tyr, pyridine hydrochloride, 82Br-labeled, pyridine perbromate, L-Tyrosine, Tyrosin, chemical structure, 2H-labeled, chemical compositionsodium salt, para Tyrosine, d230, Cysteine Hydrochloride, chemical properties, single-organism developmental process, Lysine Hydrochloride, hydrogen, Aminosaeure, Aminocarbonsaeure, Amino acid, dTAFII250, protein, pyridine disulfate, alpha-amino acid, Development, Medication, protein-containing complex, Pharmaceutical Development, EfW1, pyridine phosphate, dmTAF[[II]]230, protein polypeptide chains, Lysine Acetate, pyridine ion (2+), potassium salt, pyridine, polypeptide chain, dmTAF1, Taf230, 2, Lysine, Half-Cystine, protein aggregate, Drug Target Prediction, TST1, L Lysine, TAF250, catalyseur, Taf200, pyridine diphosphate, TPC, amino acids, hydrogen fluoride, dTAF[[II]]250, THMD4, THMD3, TFIID TAF250, pre-mortem, K, cel, pyridine monohydrate, cell, L Cysteine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, 3-(p-Hydroxyphenyl)alanine, Medication Development, epsilon-diaminocaproic acid, hydrogen iodide, Taf1p, proteins, labeling, Y, free, pyridine perchlorate, Katalysator, pyridine hydride, dTAF250, lithium salt, LYS, L Tyrosine, Pharmaceutical, Lysin, Tyr, 82Br-labeled, catalizador, pyridine perbromate, Half Cystine, Tyrosin, TAF, chemical structure, 2H-labeled, chemical composition, hydrogen bromide, dTAF[[II]]230, TAF[[II]]250, chemical characterization, Zinc Cysteinate, protein complex, Aminokarbonsaeure, monopyridine phosphate, pyridine cyanate, 2-Amino-3-(p-hydroxyphenyl)propionic acid, TAF200, total expressed protein, l(3)84Ab, alpha-amino acids, BG:DS00004.13, para-Tyrosine, 2900089E13Rik, TAFII-250, TAF250/230, alpha-amino carboxylic acids, Cell, pyridine ion (1-), Tyrosine, dTAF230, development, pyridine sulfate (2:1), TAFII250, Prediction, native protein, natural protein, tirosina, Acetate, p230, MUP1, Protein, MCPHA, lysine, pyridine hydride (2:1), pyridine sulfate, TAF[[II]]250/230, pyridine monophosphate, TFIID, catalyst, L-Lysine, tyrosine, pyridine phosphate (2:1), Target Prediction, Drug Target Predictions, PTC, Taf[[II]]250, Amino Acid, Acid, pyridine dinitrate, TAF[[II]]230, Amino acids, pyridine nitrate, Protein., L-isomer, pyridine monosulfate, L-Cysteine, TAF[II]250, alpha, chemical content, Amino, CG17603, TAF[[II]], L isomer, Drug, Computational Prediction of Drug-Target Interactions, living, DmelCG17603, Taf250, D10S170, SR3-5, H4, pyridine hydrochloride, Drug Target, Acids, L-Tyrosine, DNC, 6-diaminohexanoic acid, Enisyl, Proteomes, TAF230, TAF1PXD023794falseTriazine pyridine chemistry for selective tyrosine labelling of proteinsChemoselective reactions allowing for amino acid-specific modification are essential for protein bioconjugation and covalent drug development. Apart from Lysine and Cysteine with superior nucleophilic side chains, other amino acid-selective reactions are also needed but not well developed. Herein, we report the development of the biocompatible and catalyst-free triazine-pyridine chemistry (TPC) for tyrosine-specific labelling under physiological conditions and profiling in whole proteome. TPC exhibited high tyrosine chemoselectivity in biological systems, displayed potentials in tyrosine-guided protein labelling, and had biocompatibility in living cells. The development of TPC based tyrosine labelling agents would offer additional tools in native protein chemical modification.Mon Jan 25 03:35:00 GMT 2021MSV000086762