{"database":"MassIVE","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://massive-ftp.ucsd.edu/v03/MSV000087876/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":0,"searchCount":0},"additional":{"omics_type":["Proteomics"],"submitter":["Junqi Song"],"instrument_platform":["LTQ Orbitrap"],"species":["Arabidopsis Thaliana (ncbitaxon:3702)"],"full_dataset_link":["https://massive.ucsd.edu/ProteoSAFe/dataset.jsp?task=75294b1aa1f446ad9dc30dc99cd30af1"],"submitter_email":["junqi.song@ag.tamu.edu"],"submitter_affiliation":["TAMU Agrilife Dallas Center"],"sample_protocol":[""],"repository":["MassIVE"],"file_size":["4"],"ptm_modification":["PARylation"],"data_protocol":[""],"pubmed_abstract":["Poly(ADP-ribosyl)ation (PARylation) is a posttranslational modification reversibly catalyzed by poly(ADP-ribose) polymerases (PARPs) and poly(ADP-ribose) glycohydrolases (PARGs) and plays a key role in multiple cellular processes. The molecular mechanisms by which PARylation regulates innate immunity remain largely unknown in eukaryotes. Here we show that Arabidopsis UBC13A and UBC13B, the major drivers of lysine 63 (K63)-linked polyubiquitination, directly interact with PARPs/PARGs. Activation of pathogen-associated molecular pattern (PAMP)-triggered immunity promotes these interactions and enhances PARylation of UBC13. Both parp1 parp2 and ubc13a ubc13b mutants are compromised in immune responses with increased accumulation of total pathogenesis-related (PR) proteins but decreased accumulation of secreted PR proteins. Protein disulfide-isomerases (PDIs), essential components of endoplasmic reticulum quality control (ERQC) that ensure proper folding and maturation of proteins destined for secretion, complex with PARPs/PARGs and are PARylated upon PAMP perception. Significantly, PARylation of UBC13 regulates K63-linked ubiquitination of PDIs, which may further promote their disulfide isomerase activities for correct protein folding and subsequent secretion. Taken together, these results indicate that plant immunity is coordinately regulated by PARylation and K63-linked ubiquitination."],"pubmed_title":["Coordinated regulation of plant immunity by poly(ADP-ribosyl)ation and K63-linked ubiquitination."],"pubmed_authors":["Yao Dongsheng D, Arguez Marcus A MA, He Ping P, Bent Andrew F AF, Song Junqi J"],"description_synonyms":["PAR, Par, par6, Therapy, dmPar-6, DmNa[[v]]1, AW260507, SXR, olfD, Proteins, PRR, Emv66, FBN, Gene, bas, CG5884, Spectrum Analyses, DmNav1, ONR1, Spectrum Analysis, HSPC222, DmNa[[v]], par, DmelCG5884, ACMICD, Spectroscopy, MS, 2310036I02Rik, ECTOL1, dPAR-6, Protein, Gene Products, Mass, hJT, MFS1, PARq, Hydroxamic Acid, Analysis, DPar-6, l(1)14Da, DmNa[[V]], uPAR-2, WMS, Mass Spectrum Analyses, BXR, WMS2, Mass Spectroscopy, Dm-Par6, uPAR-3, dPar-6, Hydroxamic, Mass Spectrum Analysis, treatment, Acid, Mass Spectrum, bss, SAR, l(1)ESHS48, Analyses, PXR, DmPAR-6, HJTB, DmPar6, Spectrometry, MASS, uPAR, CG9907, DmPar-6, Treatments, Protein Gene Products, OCTD, Gene Proteins, sbl-1, Dmpar6, Therapeutic, PAR-6, SSKS, DmelCG9907, disease management, Dm-Par-6, PAR6, Par6, Therapies, Mass., Ocd, Plaur3, Treatment, PAR2, Acids, PAR1, GPHYSD2, sbl, DPar6, SGS, Par-6"],"pubmed_abstract_synonyms":["projections, DmelCG40411, posttranslational modification, CG18319, Lysine Hydrochloride, Globular Protein Folding, A., Pathogen Associated Molecular Patterns, UBIQUITIN CONJUGATING ENZYME 13A, UBIQUITIN CONJUGATING ENZYME 13B, beta-tubulin folding, Poly(ADP-ribose) Polymerase, Cardaminopsis, F9K20_8, 1500026J17Rik, Glycosylation Site Binding Protein, Lysine Acetate, A. thalianas, Poly ADP Ribose Transferase, Plant Immune Systems, 2, Poly ADP-Ribose, Sulfhydryl-Disulfide, ADPRT, CG17696, L Lysine, MEG4, BB101821, posttranslational amino acid modification, Adprp, stimulation by symbiont of host programmed cell death, K, ADPRT1, Adprt, catabolism, AI893648, ADPRT2, Bodily, Innate Immune Responses, Eucarya, Mouse-ear, chaperonin-mediated tubulin folding, Secretion, LYS, BEN, Ben, Poly-Adenosine, Lysin, Secretions, Site-Binding Protein, Role Concepts, Disulfide-Isomerases, Glycosidases, Poly ADP-Ribose Synthase, F16D14.16, Poly ADP Ribosylations, Thioltransferase, Immunity, Modifications, Poly ADPR, F16D14_16, Poly-ADPR, Ribosylations, exocrine gland fluid/secretion, Bodily Secretion, DmIKKgamma, YME1L, Role Concept, Globular Protein, co-chaperonin activity, Interchange Enzyme, Playthings and Play, dIKK, ER, shelf, Role, secretion, Plant Immune Response, Protein Foldings, Endoglycosidases, activation, Synthase, Adenosine 5'-(trihydrogen diphosphate), Processing, IKK-gamma, Molecules, Eukarya, ADP Ribosylation, alpha, Protein Disulfide-Isomerase, Controls, projection, ridge, Glycosylation Site-Binding Protein, Pathogen Associated Molecular Pattern, co-chaperone activity, Globular Protein Foldings, Amino Acid Modification, Disulfide Isomerase, Immunities, ADPRT 1, activation by symbiont of host programmed cell death, P'-5-ester with D-ribose, Ubiquitin carrier protein N, Sulfhydryl-Disulfide Interchange, ADP Ribose, Posttranslational Modifications, 5830444G22Rik, Innate, exocrine gland secretion, Posttranslational Modification, Glycoside Hydrolase, lamellae, LD21673.3prime, regulation by symbiont of host system process, Foldings, UbcH-ben, DmelCG18319, process of organ, dIKK-gamma, Posttranslational, lamella, Plant Immune System, Ubiquitin-protein ligase N, induction by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction, DmIKK-gamma, thalianas, Gene Products, Post-Translational Modifications, Lysine, C80510, Globular, Post Translational, Poly(ADP-Ribose), PARylation, Toy, Modification, Bend, Playthings, BLU, Cresses, Trypanothione Glutathione Thioltransferase, homopolymer, Presenilin-associated metalloprotease, adprt1, Diphosphate-Ribose, C78626, Post-Translational Amino Acid Modification, Sulfhydryl-Disulfide Interchange Enzyme, Enzyme, Puppets, Quality Controls, bodily secretion, Disulfide Interchange Enzyme, Protein Folding, Polymerase, Posttranslational Protein, F17F16.19, Cress, parp-1, laminae, Non Specific, Exoglycosidases, Puppet, 3.4.24.-, Poly-ADP-Ribosylations, Natural Immunity, PolyADPRibosylation, Eukaryote, hemolysin activity, degradation, Arabidopsis thaliana, Proteins, Thiol-Disulfide, Post-Translational Protein Modification, AL022654, Glycosylation Site-Binding, Concept, eukaryotes, Reticulum, IKKgamma, Poly ADP Ribose Synthase, Acetate, Resistance, Poly ADP Ribose, L-Lysine, organ process, Plant Immune Responses, Dmikkgamma, Post Translational Protein Processing, Disulfide Interchange, thaliana, CG16910, post-translational amino acid modification, Innate Immune Response, processes, Gene Proteins, padprt-1, PARP-2, Thiol Disulfide Transhydrogenase, PARP-1, D.PARP, Post-Translational Protein Processing, Poly-Adenosine Diphosphate-Ribose, Eucaryotae, Enisyl, biochemical pathways, Post Translational Amino Acid Modification, Immune Systems, nonspecific immune response, positive regulation by symbiont of host non-apoptotic programmed cell death, Protein Processing, Adprt1, Adprt2, Hydrolase, Trypanothione-Glutathione, Arabidopsis thalianas, Poly(ADP-Ribose) Transferase, Roles, Concepts, pathogenesis, Poly-ADPRibosylation, Disulfide-Isomerase, ADPRTL2, Protein disulfide-isomerase, ADPRTL3, IKKg, PARP Polymerase, KEY, Key, Post-Translational Protein, Immune Processes, Immune Responses, Ubiquitylation, ARTD1, Post-Translational, ARTD2, Natural, YME1-like protein 1, Mouse-ear Cress, epsilon-diaminocaproic acid, Posttranslational Protein Processing, Non-Specific Immunity, eucaryotes, Folding, Immune, papilla, Adprtl2, biotransformation, 6.3.2.19, ubiquitination, Poly-ADP-Ribosylation, Arabidopses, Pathogen-Associated Molecular Pattern, anon-WO03040301.242, Post-Translational Modification, ubc13, Process, Ergastoplasm, external secretion, Native, lamina, flanges, pADPRT-1, pADPRT-2, A. thaliana, ER-derived quality control compartment, Sulfhydryl Disulfide Interchange Enzyme, Sensory, Poly(ADPRibosyl)ation, UbcD3, chaperone activity, Exoglycosidase, PARP1, Post Translational Modifications, Kenny, Responses, lysine, modulation by symbiont of host system process, Plaything, alpha-tubulin folding, Glycosidase, PARylations, Trypanothione-Glutathione Thioltransferase, Protein Disulfide Isomerases, Native Immunity, PTM, Poly ADPRibosylation, shelves, System, Toys, Control, Plant, Quality, Plant Immune, Glycoside, Natural Resistance, CG17718, Arabidopsis, DmelCG16910, Endoglycosidase, post-translational modification, F9K20.8, multichaperone pathway, Pathogen Associated Molecular Pattern Molecules, Hydrolases, UBCHBEN -  UBC13, Glycohydrolase, ubiquitin-conjugating enzyme 35, ubiquitin-conjugating enzyme 36, HEL-S-71, Protein Disulfide Isomerase, Thiol-Disulfide Transhydrogenase, Plays, Innate Immunity, Post-Translational Protein Modifications, exocrine gland fluid, ADP-Ribosyltransferase (Polymerizing), exocrine gland fluid or secretion, Poly(ADPR) Polymerase, Aspartl2, Eukaryotes, Gene, Immune System, BEST:LD21673, PAMPs, Ubc13, Transhydrogenase, CG40411, Glycosylation, chaperonin ATPase activity, Post Translational Modification, non-chaperonin molecular chaperone ATPase activity, glycoprotein-specific chaperone activity, UBC13, Glycohydrolases, dmIKKgamma, Disulfide, IKK[[gamma]], ubiquitin-conjugating enzyme 13, Bendless-like ubiquitin-conjugating enzyme, NAD+:poly(adenosine diphosphate D-ribose)-acceptor ADP-D-ribosyltransferase, ridges, causes, posttranslational protein modification, ERQC, Protein Modifications, Protein Disulfide, secreted substance, ADP Ribosylations, Immune Response, IKK, Posttranslational Amino Acid Modification, Poly ADP, Ubiquitylation., causality, Play, PAMP, Poly ADP Ribose Polymerase, Mouse ear, Immune Process, nj-262, poly(ADP-ribose) polymerase 1, FTSH, UBC13A, UBC13B, activation by organism of non-apoptotic programmed cell death in other organism, Plant Immunities, Sensory Processing, innate immunity, Eukaryotas, Ribosylation, ATPARP1, ATP-dependent metalloprotease FtsH1, sPARP-1, Protein, Systems, Protein Modification, protein complex assembly, flange, Isomerase, Poly-ADPRibosylations, Pathogen-Associated Molecular Patterns, biodegradation, Poly, PARP, UbcH13, ER quality control compartment, Ribose, Poly(ADPribose) Polymerase, Mouse-ear Cresses, parp, Poly(ADP-Ribose) Synthase, CG17685, Protein Gene Products, Parp-1, Eukaryotae, Post Translational Protein Modification, Endoplasmic, ppol, Non-Specific, Response, dPARP, PolyADPRibosylations, Dm.pARTa, PPOL, 6-diaminohexanoic acid, Meg-4, Poly(ADP-Ribosyl)ation"],"pubmed_title_synonyms":["PARylations, Regulations, Poly-ADP-Ribosylations, Immune Responses, Immune Systems, PolyADPRibosylation, Poly ADPRibosylation, Plant Immune Responses, Poly, Formal Social Control, Poly ADP Ribosylations, Plant Immunities, Immunity, System, Control, Plant, Immune System, ADP Ribosylation, Plant Immune, Controls, Ribosylation, Social Controls, Poly(ADPRibosyl)ation, Social, Ribosylations, Plant Immune System, Immune Response, ADP Ribosylations, Social Control, Immunities, Poly ADP, Systems, Ubiquitylation., Responses, Response, Plant Immune Systems, Poly-ADPRibosylation, regulation, Plant Immune Response, ubiquitination, PolyADPRibosylations, Poly-ADP-Ribosylation, Regulation, Formal Social Controls, Poly(ADP-Ribosyl)ation, Poly-ADPRibosylations, PARylation"],"name_synonyms":["Prolyl 4-hydroxylase subunit beta, HEL-S-71, anon-WO03040301.242, DmelCG6988, ER protein 59, ubc13, CG18319, P4Hbeta, Proteins, p55, Dpdi, UbcH-ben, Pdia1, Gene, AL022654, mKIAA0994, DmelCG18319, PDI-Q2, DSI, UbcD3, PDA2, 1500026J17Rik, PDIA1, Ubc13, Ubiquitin-protein ligase N, ERp61, ERp60, Protein, Gene Products, CG6988, GIT, UBC13, ERp59, ERp57, Grp58, PDIR, EP(3)1022, PAD1, PDIP, dpdi, ubiquitin-conjugating enzyme 13, 58kDa, Bendless-like ubiquitin-conjugating enzyme, Erp, PLC[a], PO4HB, BB101821, Thbp, Bend, BLU, PROHB, UbcH13, Protein., 5.3.4.1, PHDB, PDI, Pdi, Pdi2, PDI1, Endoplasmic reticulum resident protein 59, PO4DB, Plca, Protein Gene Products, Gene Proteins, ERBA2L, HPAD10, BEN, Ben, PI-PLC, Ubiquitin carrier protein N, 6.3.2.19, pdi, Cellular thyroid hormone-binding protein, UBCHBEN -  UBC13, nj-262"],"citation_count":["0"],"additional_accession":[]},"is_claimable":false,"name":"PARylation of UBC13 and PDI proteins","description":"NH2OH was used to remove PAR from the PARylated proteins. This treatment left on the PARylated residues a hydroxamic acid derivative, which has a signature mass increase of +15.0109 Da and could be distinguished by mass spectrometry.","dates":{"publication":"Fri Jul 23 13:37:00 BST 2021"},"accession":"MSV000087876","cross_references":{"pubmed":["34418551"]}}