MassIVEapplication/xmlftp://massive-ftp.ucsd.edu/v04/MSV000088345/primary200OK0000ProteomicsAnna KashinaQ Exactive PlusQ Exactive HFHomo Sapiens (ncbitaxon:9606)https://massive.ucsd.edu/ProteoSAFe/dataset.jsp?task=5ffce2c2d4a144b49a4c0240afcb4b37Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicineakashina@upenn.eduMassIVE27UNIMOD:21 - "Phosphorylation."UNIMOD:7 - "Deamidation."UNIMOD:1 - "Acetylation."UNIMOD:35 - "Oxidation or Hydroxylation."Fresh, COVID19, Disease, Coronavirus Disease 19, Frozen Plasma, β-CoV, Fresh Frozen Plasma, beta-CoV, protein complex, Blood, Proteins, COVID-19, SARS-CoV-2, Gene, Virus Infection, COVID-19 Virus Diseases, 2019 novel coronavirus, protein, 2019 Novel Coronavirus Disease, SARS-CoV-2 Infections, 2019 nCoV Infection, protein-containing complex, COVID 19 Virus Infection, Plasmas, Virus Disease, Client, 2019 nCoV Disease, COVID-19 Virus Disease, 2019-nCoV Infection, Frozen Plasmas, protein polypeptide chains, native 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Modification, Plasma, 2019 Novel, betacoronavirus, Disease 2019, Organ Donor, prophylaxis, Post Translational Protein Processing, CG4216, portion of plasma, Wuhan, Understanding, SARSr-CoV, COVID-19 Pandemics, COVID-19 Pandemic, SARS-coronavirus 2, post-translational amino acid modification, Protein Gene Products, Urbani SARS-Associated, Gene Proteins, Post Translational Protein Modification, Therapeutic, control, Families, SARS virus, Modern Man, cardinality, Post-Translational Protein Processing, SARS Virus, Treatment, COVID 19 Virus, regulation, Urbani, SARS Associated Coronavirus, Severe acute respiratory syndrome coronavirus, Relatives, COVID 190falseProtein Posttranslational Signatures Identified in COVID-19 Patient PlasmaSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious virus of the coronavirus family that causes coronavirus disease-19 (COVID-19) in humans and a number of animal species. COVID-19 has rapidly propagated in the world in the past 2 years, causing a global pandemic. Here, we performed proteomic analysis of plasma samples from COVID-19 patients compared to healthy control donors in an exploratory study to gain insights into protein-level changes in the patients caused by SARS-CoV-2 infection and to identify potential proteomic and posttranslational signatures of this disease. Our results suggest a global change in protein processing and regulation that occurs in response to SARS-CoV-2, and the existence of a posttranslational COVID-19 signature that includes an elevation in threonine phosphorylation, a change in glycosylation, and a decrease in arginylation, an emerging posttranslational modification not previously implicated in infectious disease. This study provides a resource for COVID-19 researchers and, longer term, will inform our understanding of this disease and its treatment.Wed Nov 10 11:51:00 GMT 2021MSV000088345