{"database":"MassIVE","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://massive-ftp.ucsd.edu/v06/MSV000092486/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":0,"searchCount":0},"additional":{"omics_type":["Proteomics"],"submitter":["Monique Ryan"],"instrument_platform":["QTRAP 6500+"],"species":["Homo Sapiens (ncbitaxon:9606)"],"full_dataset_link":["https://massive.ucsd.edu/ProteoSAFe/dataset.jsp?task=388dc772c3eb4429ba450f241efd6dbb"],"submitter_email":["monique.ryan@murdoch.edu.au"],"submitter_affiliation":["Murdoch University"],"sample_protocol":[""],"repository":["MassIVE"],"file_size":["1,686"],"ptm_modification":["MS:1002864 - No post-translational-modifications are included in the identified peptides of this dataset"],"data_protocol":[""],"name_synonyms":["Research Related Injuries, Injury, inflammatory response, Wound, Injury and Wounds, Physical, wound, Physical Traumas, inflammation, injury, Injuries and Wounds, Injuries, trauma, Injuries., Phenotypes, Wounds, traumatic injury, Wounds and Injury, Traumas, Trauma, Burn, Research-Related Injuries, Physical Trauma, Research-Related Injury, Severe, Research-Related"],"description_synonyms":["glicoproteinas, Ghrfr, High Density Lipoproteins, O-Glycosylated, beta-Lipoproteins, Activity, determination, Laboratory, Incidences, Wound, Intestinal peptide PHM-27, Blood, Physical, Pb, Person-time Rates, beta Lipoproteins, Phosphatidyl-N-trimethylethanolamine, Choline phosphatide, Proportion, Circulating, HDL Lipoproteins, PtdIns, injury, prevention, trauma, phm27, vip-A, Relative, Glycoprotein, Glycerol, diseases, glycoproteins, Glycerol Phosphoglycerides, responsivity, 1, 10.5, diseases and disorders, High-density lipoprotein, Incidence Rate, Analysis, LDL-2, Research Activity, Low Density Lipoproteins, LDL-1, glycoproteine, Laboratory Research, prevention and control, Research-Related, adult, 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disease, Inositide, C-Glycosylated, Fresh Frozen Plasma, Lecithol, Phosphatidylinositol, Spectrum Analyses, Ximpact, Normalcies, Injuries and Wounds, protrusion, Intervention or Procedure, Secondary Attack Rate, surface, Rate, Wounds, Metabolism, Low Density Lipoprotein 2, Low Density Lipoprotein 1, Mass, disease or disorder, Phosphatidyl, even, Attack Rates, Inositide Phospholipid, Choline Glycerophospholipids, Mass Spectroscopy, Normalities, reactivity, vip|phi27, Blood Plasma, Intestinal peptide PHI-42, Injury, lipid metabolism, Low Density Lipoprotein, Phospholipid, occurrence, Research, interventionDescription, prevalence, glycoproteines, LDL Lipoproteins, Interventional, Low-Density Lipoprotein, O-Glycosylated Proteins, non-neoplastic, High Density, Cumulative, Nuclear magnetic resonance spectroscopy, phosphatidylcholines, Traumas, Clients, Blood Plasmas, lead, Person-time, Phospholutein, Person time Rate, Chronic, disorder, site, Development and Research, species, Incidence 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2-Diacyl-sn-glycero-3-phosphocholine, Relative Risk, Intervention, Plasma, Mass Spectrum, Phosphoinositide, Phospholipids, Normality, body surface, N-Glycosylated Proteins, prophylaxis, plumbum, Risks, wound, 2-D projection, l(2)46Ce, portion of plasma, patient, Phosphatidylglycerol, Choline Phosphoglycerides, endemics, sample population, Phosphatidylserine, l(2)46Cg, Injuries, Phosphatidyl Choline, alpha Lipoprotein, High, l(2)46CFj, l(2)46CFh, Secondary, High Density Lipoprotein, Phosphatidyl Glycerol, Incidence Proportion, Inositol Phospholipid, cross-sectional, control, l(2)46CFp, Attack, Burn, epidemics, PC, assay, response, Low-Density Lipoproteins, PI, E(eve), Severe, RWDD5, VIP, l(2)46CFg"],"citation_count":["0"],"additional_accession":[]},"is_claimable":false,"name":"Non-severe burns induce a prolonged systemic metabolic phenotype indicative of a sustained inflammatory response to injury ","description":"Globally, burns are a significant cause of injury that can cause substantial acute trauma as well as lead to increased incidence of chronic co-morbidity and disease. To date, research has primarily focused on the systemic response severe injury, with little in the literature reported on impact of non-severe injuries (<15% total burn surface area; TBSA). To elucidate the metabolic consequences of non-severe burn injury, longitudinal plasma was collected from adults (n=35) who presented at hospital with a non-severe burn injury at admission, and at 6 week follow up. A cross-sectional baseline sample was also collected from non-burn control participants (n=14). Samples underwent multiplatform metabolic phenotyping using 1H nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry to quantify 112 lipoprotein and glycoproteins signatures and 852 lipid species from across 20 subclasses. \nMultivariate data modelling (Orthogonal projection to latent structures-discriminate analysis) revealed alterations in lipoprotein and lipid metabolism when comparing baseline control to hospital admission samples, with the phenotypic signature found to be sustained at follow up. Univariate (Mann-Whitney U) testing and OPLS-DA indicated specific increases in GlycB (p-value <1.0e-4), low density lipoprotein-2 subfractions (Variable importance in projection score; VIP >6.83e-1) and monoacyglyceride (20:4)(p-value <1.0e-4) and decreases in circulating anti-inflammatory high-density lipoprotein-4 subfractions (VIP >7.75e-1), phosphatidylcholines, phosphatidylglycerols, phosphatidylinositols and phosphatidylserines. \nThe results indicate a persistant systemic metabolic phenotype that occurs even in cases of non-severe burn injury. The phenotype is indicative of an accute inflammatory profile which continues to be sustained post-injury, suggesting an impact on systems health beyond the site of injury. The phenotypes contained metabolic signatures consistent with chronic inflammatory states reported to have elevated incidence post- burn injury. Such phenotypic signatures may provide patient stratification opportunities, to identify individual responses to injury, personalise intervention strtegies and improve acute care, reducing risk of chronic co-morbidity. \n","dates":{"publication":"Wed Jul 19 21:33:00 BST 2023"},"accession":"MSV000092486","cross_references":{}}