MassIVEapplication/xmlftp://massive-ftp.ucsd.edu/v07/MSV000094754/primaryOK200Jeffrey L. Bosehttps://massive.ucsd.edu/ProteoSAFe/dataset.jsp?task=27c679eafc494f2796bcf3e65bc0319fjbose@kumc.eduMassIVE21UNIMOD:4 - "Iodoacetamide derivative."UNIMOD:35 - "Oxidation or Hydroxylation."ProteomicsOrbitrap AscendStaphylococcus Aureus Subsp. Aureus Usa300 (ncbitaxon:367830)University of Kansas Medical CenterDmelCG9538, Virulence, Health Problem, BamF, Materials, Activity, BamC, AP-2, alpha-Spe, Human Figures, Infestations and Infections, Visible Light, protein, infectivity, alpha-Spc, CG31654, Social Controls, MAGE-E1 antigen, dmTAF[[II]]230, l(3)04276, protein polypeptide chains, Background, diseases, Cultural, hnu, Problems, alpha-adaptin, diseases and disorders, DmelCG10422, protein aggregate, animal, Microeconomic, Staphlococcus pyogenes citreus, foton, Formal Social Controls, alpha-spec, Health Problems, Progression, viral infection, human disease, Theory, Utility Theories, CG4260, TFIID TAF250, reference sample, cel, Household Consumption, Staphilococcus aureus, Tissue, Economic Policies, Parts, Micrococcus aureus, proteins, Living Costs, Body Parts and Fluids, AUXIN TRANSPORT PROTEIN EIR1, alpha-spectrin, Social, Pathogenicity Factors, Hemolysins, TNFSF14, HCA1, International Health, Figure, WAVY ROOTS 6, Exacerbation, Human Bodies, Body Parts, Household Consumptions, Homo sapiens disease, Economic, Infections and Infestations, Theories, anon-WO0140519.74, gamma, dTAF[[II]]230, Home Economics, ARABIDOPSIS THALIANA PIN-FORMED 2, Radiation, Indices, Index, UNQ391/PRO726, Global, Hypothesis, Disease Exacerbation, Aptitudes, TAF200, ham, Light, TAFII-250, TAF250/230, ada, Macroeconomic Factors, Economics, Cultural Belief, Ability, Virulence Factor, alphaSpec, TAFII250, Economic Condition, Cultural Background, D-Ada, Household, LIGHT, Cultures, Utility Theory, DAMAGE, Hepatocellular carcinoma-associated protein 1, Diseases, cg4260, Pathogenicity, Genetic Materials, CG9538, dAP-2a, Macroeconomic, simple tissue, Hemalysins, regulator, Problem, spectrin, Genetic Material, Hemolysin, POLAR-AUXIN-TRANSPORT EFFLUX COMPONENT AGRAVITROPIC 1, Visible Radiations, l(2)06694, MENE (2L)-A, WAV6, Visible Radiation, Factors, whole organism, HVEML, Cultural Beliefs, Consumer Price Indices, Control, Infection and Infestation, INSDC_feature:gene, Agr5, alpha, AP-2alpha, Controls, CG17603, TAF[[II]], AGR1, Home, DmelCG4260, International, Condition, International Health Problems, disease, Health, light quantum, Staphylococcus pyogenes aureus, Easterlin Hypothesis, Taf250, Material, SR3-5, AGR, Agr, AGRAVITROPIC ROOT, Koerper, Cistron, medical condition., mMage-e1, Regulation, TAF230, Remittances, PIN-FORMED 2, Regulations, other disease, Policies, alpha-Ada, anon-EST:fe2E2, d230, l(3)alpha-Spec, Bodies, agr, alpha-Spect, Utility, Gene, dTAFII250, protein-containing complex, EfW1, l(2)SH2 0460, fs(3)neo61, Human, Easterlin, Ly113, MUL3.3, CG10422, alpha-ada, polypeptide chain, dmTAF1, Worldwide, Taf230, klo, Gene Products, Clinical Progression, Pathogenicity Factor, Worldwide Health, disease or disorder, alpha-Sp, MUL3_3, CG1977, TAF250, study, ETHYLENE INSENSITIVE ROOT 1, Taf200, dTAF[[II]]250, Clinical, Genetic, cell, Lichtquant, dre3, Taf1p, Microeconomic Factors, Cultural Relativisms, AI847422, Visible, Economic Conditions, Alpha-Adaptin, clinical infection, non-neoplastic, dTAF250, Infestation and Infection, Abilities, Clinical Course, Custom, Capital, photon, Customs, disorder, Skin infections, Staphylococus aureus, TR2, TAF, PIN2, l(3)dre3, Controlled, Policy, Economic Policy, Disease, Controlling, TAF[[II]]250, alpha-Spectrin, 3A9, Formal Social Control, World, body, protein complex, DmelCG1977, Conditions, Proteins, Alpha-dystrobrevin-associated MAGE Protein, disorders, l(3)84Ab, whole body, medical condition, Factor, BG:DS00004.13, Production, World Health, Cultural Backgrounds, Living Cost, Cistrons, CD258, Cell, dTAF230, Consumption, ATPIN2, Belief, International Healths, native protein, natural protein, Consumer Price Index, Consumer Price, Social Control, p230, Protein, Infection, TAF[[II]]250/230, condition, MENE(2L)-A, TFIID, alphaSp, Radiations, Taf[[II]]250, AGRAVITROPIC ROOT 1, Staphylococcus aureus subsp. anaerobius, TAF[[II]]230, D-alphaAda, mating_type_alpha, RGD1560259, HVEM-L, Photoradiation, FCP-B, Healths, Human Figure, Talents, TAF[II]250, International Health Problem, Body, LTg, Streptococcus aureus, Protein Gene Products, Gene Proteins, AP2, DmelCG17603, Micrococcus pyogenes, Photoradiations, Remittance, l(3)62Bd, Bam-C, Figures, Talent, Cost of Living, BAM, Bam, alpha mating type (yeast), l(2)SH0460, alfa-Spec, virulence, regulation, Relativism, Cultural Relativism, General activity, Spec, TAF1DmelCG9538, PIN-FORMED 2, Regulations, dermis plus epidermis plus hypodermis, the integument, acting on phosphatidylcholine, region of skin, Oct-11a, ARABIDOPSIS THALIANA PIN-FORMED 2, pelt, Process, Social Controls., Formal Social Control, Otf-11, Skn-li, agr, heat-labile hemolysin, skin zone, integumental organ, epidermis, ATPIN2, MUL3.3, skin plus hypodermis, Clostridium welchii alpha-toxin activity, Oct11, skin region, Social Control, BC033609, CG9538, MUL3_3, Skin-1a, cytopathology, alpha-toxin, tegument, Skin, Formal Social Controls, POLAR-AUXIN-TRANSPORT EFFLUX COMPONENT AGRAVITROPIC 1, integumentum commune, Skn-1a, lipophosphodiesterase I activity, skin benign neoplasm, AGRAVITROPIC ROOT 1, WAV6, ETHYLENE INSENSITIVE ROOT 1, Immune Processes, Immune Responses, skin, histopathology, vertebrate integument, dermoid system, Control, entire skin, Agr5, Controls, SKIN, AGR1, AUXIN TRANSPORT PROTEIN EIR1, mKIAA0493, Epoc-1, phospholipase C, Social, skin organ, portion of skin, vertebrate epidermis, Immune Response, Immune, integument, AGR, Agr, AGRAVITROPIC ROOT, Fam91a1, Otf11, Pathologies, WAVY ROOTS 6, Response, regulation, entire integument, biopsy, PIN2, Immune Process, phosphatidylcholine cholinephosphohydrolase activity, AV220772, dermal system, Regulation, skin and subcutaneous tissue, anon-WO0140519.74, Clostridium oedematiens beta- and gamma-toxins activityPXD052262falseYjbH contributes to S. aureus skin pathology and immune response through Agr-mediated alpha-toxin regulationStaphylococcus aureus is a global health threat that can cause a multitude of diseases in many different areas of the body and is the leading cause of skin infections. This bacterium can produce a variety of proteins that contribute to virulence and disease progression. These virulence factors include alpha-hemolysin (Hla), which can kill many different cell types in the human body. In this study, we identified a new protein that contributes to Hla production, YjbH. It does so by controlling the activity of the Accessory Gene Regulator (Agr), a major player in the modulation of proteins produced in the bacterium. We demonstrate that without YjbH, S. aureus cultures produce less Hla, and this is corroborated during infection. Accordingly, when YjbH is present, tissue damage is greater during infection than when it is absent. Overall, our study sheds light on the complex regulation involved in virulence factor production by S. aureus and its ability to cause a wide range of diseases. Tue May 14 08:46:00 BST 2024MSV000094754