{"database":"MassIVE","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://massive-ftp.ucsd.edu/v09/MSV000097955/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"submitter":["Midhat S Farooqi"],"full_dataset_link":["https://massive.ucsd.edu/ProteoSAFe/dataset.jsp?task=9d2254e0b3234576a23d3eeacc459a99"],"submitter_email":["msfarooqi@cmh.edu"],"sample_protocol":[""],"repository":["MassIVE"],"file_size":["52"],"ptm_modification":["UNIMOD:4 - \"Iodoacetamide derivative.\"","UNIMOD:35 - \"Oxidation or Hydroxylation.\""],"data_protocol":[""],"omics_type":["Proteomics"],"instrument_platform":["Orbitrap Ascend"],"species":["Homo Sapiens (ncbitaxon:9606)"],"submitter_affiliation":["Children's Mercy Hospital"],"additional_accession":["PXD064162"]},"is_claimable":false,"name":"Integrated multi-omic analysis reveals novel subtype-specific regulatory interactions in pediatric B-cell acute lymphoblastic leukemia","description":"In this study, we performed proteomic and phosphoproteomic profiling of B-cell acute lymphoblastic leukemia (B-ALL) samples collected at diagnosis and remission from pediatric leukemia patients with one of two subtypes of B-ALL: BCR::ABL1-like (Ph-like) and ETV6::RUNX1. We analyzed each dataset, as well as existing RNAseq data at diagnosis, to identify subtype-specific features, including increased calcium-dependent signaling in Ph-like samples. We then performed an integrated analysis of all three datasets, which enabled us to identify multiple layers of regulation, including subtype-specific phosphorylation of known cancer-associated proteins. Taken together, these data add to our understanding of the molecular profile of Ph-like and ETV6::RUNX1 B-ALL, demonstrating the utility of multi-omic comparison in pediatric leukemia subtype characterization. ","dates":{"publication":"Wed May 21 11:48:00 BST 2025"},"accession":"MSV000097955","cross_references":{}}