{"database":"MetaboLights","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Xlsx":["ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG_transformed_data.xlsx"],"Tabular":["ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/m_MTBLS1_metabolite_profiling_NMR_spectroscopy_v2_maf.tsv"],"Txt":["ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/i_Investigation.txt","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/s_MTBLS1.txt","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/a_MTBLS1_NMR_metabolite_profiling_NMR_spectroscopy.txt"],"Other":["ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_431.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_305.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_284.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_474.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_097.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_241.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_017.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_165.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_194.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_303.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_094.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_179.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_352.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_051.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_097.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_077.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_017.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_356.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_161.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_156.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_071.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_023.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_246.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_073.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_403.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_281.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_471.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_178.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_193.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_013.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_357.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_009.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_073.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_472.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_155.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_185.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_164.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_162.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_307.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_304.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_116.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_357.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_167.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_077.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_192.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_021.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_161.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_245.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_246.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_015.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_186.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_015.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_012.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_186.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_436.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_195.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_091.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_303.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_167.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_353.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_098.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_153.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_474.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_155.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_283.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_112.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_306.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_011.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_195.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_407.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_072.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_052.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_022.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_160.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_437.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_302.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_191.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_152.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_435.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_098.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_012.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_153.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_179.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_072.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_117.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_353.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_066.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_402.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_283.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_093.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_191.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_118.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_304.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_008.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_074.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_163.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_163.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_437.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_013.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_053.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_168.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_244.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_287.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_473.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_014.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_087.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_092.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_475.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_112.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_197.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_242.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_067.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_016.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_177.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_405.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_187.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_282.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_011.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_117.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_160.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_166.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_194.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_097.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_436.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_021.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_113.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_156.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_196.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_476.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_151.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_356.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_093.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_073.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_247.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_433.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_241.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_476.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_301.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_287.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_352.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_247.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_167.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_401.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_007.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_152.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_015.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_115.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_015.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_096.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_067.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_403.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_118.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_178.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_431.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_286.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_286.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_305.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_168.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_116.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_092.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_088.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_075.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_010.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_432.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_095.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_016.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_087.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_197.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_402.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_052.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_472.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_167.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_072.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_243.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_051.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_355.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_285.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_094.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_114.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_074.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_007.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_017.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_406.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_071.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_071.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_017.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_089.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_166.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_351.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_165.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_113.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_120.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_066.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_404.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_282.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_096.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_088.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_401.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_193.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_023.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_434.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_120.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_477.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_014.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_434.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_097.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_162.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_477.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_351.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_187.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG-19_007u_476.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_089.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_161.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_166.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_071.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_284.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_177.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_475.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_151.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_432.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_243.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_016.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_076.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_301.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_008.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_091.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_306.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_115.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_406.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_076.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_242.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_053.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_010.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_075.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_354.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_185.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_285.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_471.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_307.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_404.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_245.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_355.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_072.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_162.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_473.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_435.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_196.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_405.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_164.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_433.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_161.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_166.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_407.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_016.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_192.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_162.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_244.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_354.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_114.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_302.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_009.nmrML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_073.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_095.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG19007u_281.zip","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1/FILES/ADG10003u_022.zip"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"ftp_download_link":["ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1"],"metabolite_identification_protocol":["Assignments were confirmed by two dimensional spectroscopy including homonuclear 1H-1H Correlation Spectroscopy (COSY), 1H-13C Heteronuclear Signal Quantum Coherence (HSQC) and 1H-13C Heteronuclear Multiple Bond Correlation (HMBC) Spectroscopy."],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Nuclear Magnetic Resonance (NMR) - - - Bruker"],"publication":["A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human. 10.1152/physiolgenomics.00194.2006. PMID:17190852"],"nmr_spectroscopy_protocol":["The spectra of human urine samples were acquired on a Bruker DRX700 NMR spectrometer using a 5 mm TXI ATMA probe at a proton frequency of 700.1 MHz and ambient temperature of 27 °C."],"submitter_name":["Jules Griffin","Reza Salek"],"submitter_affiliation":["Imperial College London","International Agency for Research on Cancer"],"organism_part":["urine"],"technology_type":["NMR spectroscopy assay"],"disease":[""],"extraction_protocol":["For the human studies, midstream urine (∼15 ml) samples were collected and frozen from each volunteer. In total, 84 samples were collected from 12 healthy volunteers (7 time points, 8 males and 4 females) and 50 samples from 30 T2DM patients (1–3 time points, 17 males and 13 females) with well-controlled blood glucose maintained at normal concentrations by diet, following the guidelines issued by the American Diabetes Association, rather than medication. The healthy subjects were aged 18–55 yr, had a body mass index (BMI) ≥19 and ≤30 kg/m2 and a body mass ≥50 kg and ≤113 kg, and were free from any major disease or pregnancy. The T2DM patients were aged 30–65 yr (mean 56 ± 9 yr), had a BMI >25 and <40 kg/m2, weighed between 65 and 140 kg (mean 95 ± 19 kg), and were taking at most one oral anti-diabetic drug. T2DM patients agreed to stop treatment with oral anti-diabetic agents during the study. Subjects went through a washout period of 4 wk before sample collection and abstained from alcohol during the study; diet was controlled throughout the study."],"organism":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS1"],"author":["Jules Griffin. University of Cambridge. The Department of Biochemistry, The Sanger Building, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.. jlg40@cam.ac.uk. 01223674922.","Reza Salek. University of Cambridge. The Department of Biochemistry, The Sanger Building, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.. rms72@cam.ac.uk. 01223674948."],"data_transformation_protocol":["Spectra were processed using ACD/1D NMR Manager 8.0 with Intelligent Bucketing Integration (Advanced Chemistry Development, Toronto, ON, Canada). Spectra were integrated 0.20-9.30 ppm excluding water (4.24-5.04 ppm), glucose (3.19-3.99 ppm, 5.21-5.27 ppm), and urea (5.04-6.00 ppm). Intelligent bucketing ensures that bucket edges do not coincide with peak maxima, preventing resonances from being split across separate integral regions; a 0.04 ppm bucket width and a 50% looseness factor were used. All spectra were normalized to total area excluding the water, urea, and glucose regions."],"study_factor":["Gender","Metabolic syndrome"],"submitter_email":["r7salek@gmail.com","jlg40@cam.ac.uk"],"sample_collection_protocol":["For the human studies, midstream urine (~15 ml) samples were collected and frozen from each volunteer. In total, 84 samples were collected from 12 healthy volunteers (7 time points, 8 males and 4 females) and 50 samples from 30 T2DM patients (1-3 time points, 17 males and 13 females) with well-controlled blood glucose maintained at normal concentrations by diet, following the guidelines issued by the American Diabetes Association, rather than medication. T2DM patients agreed to stop treatment with oral anti-diabetic agents during the study. Subjects went through a washout period of 4 wk before sample collection and abstained from alcohol during the study; diet was controlled throughout the study."],"nmr_assay_protocol":["A 1D NOESY presaturation pulse sequence was used to analyze the urine samples. For each sample 128 transients were collected into 64k data points using a spectral width of 14.005 kHz (20 ppm) and an acquisition time of 2.34 s per FID."],"omics_type":["Metabolomics"],"study_design":["metabolic syndrome","Human Study Subject","Urine global profiling","nuclear magnetic resonance spectroscopy","untargeted metabolites","diabetes mellitus"],"curator_keywords":["metabolic syndrome","Human Study Subject","Urine global profiling","nuclear magnetic resonance spectroscopy","untargeted metabolites","diabetes mellitus"],"nmr_sample_protocol":["Aliquots of 400 µl urine samples were made up to 600 µl with phosphate buffer (0.2 M, pH 7.4) and any precipitate removed by centrifugation. In total, 500 µl of supernatant were transferred to 5-mm NMR tubes with 100 µl of sodium 3-trimethylsilyl-(2,2,3,3-2H4)-1-propionate (TSP)/D2O/sodium azide solution (0.05% wt/vol TSP in D2O and 1% wt/vol sodium azide)."],"metabolite_name":["unknown_d_1.235","acetone","sarcosine","a-Hydroxy-n-butyrate","n-methylnicotinate","methyl guanidine","indoxyl sulphate","citrullinate","isoleucine","n-methyl-4-pyridone-5-carboxamide","hippurate","indoxyl sulfate","unknown_s_1.27","a-hydroxyisobutyrate","glutamate","a-Hydroxy-n-valerate","methyl N-acetylvalinate","leucine","n-butyrate","a-Hydroxyisovalerate","b-hydroxy-n-butyrate","n-methylnicotinamide","adenosine","lysine","N-acetylglutamate","malate","caproylgly","creatine","allantoin","unknown_s_1.35","unknown_s_2.04","oxalacetate","Uridine","tyrosine","mhppa sulphate?","unknown_s_6.68","n-caproylglycine","a-keto-b-methyl-N valerate","desaminotyrosine","4-aminohippurate","isocaproate","glutamine","dimethylglycine","ethanol","methylmalonate","N-acetylaspartate","succinate","uridine","acetate","3,4-dihydroxymandelate","formate","ornithine","creatinine","mhppa sulphate","unknown_t_1.205","n-methyl-2-pyridone-5-carboxamide","trimethylamine","dimethylamine","ketoglutarate","alanine","unknown_m_2.97","glycolate","dihydroxymandelate","citrate","unassigned pyrimidine","unknown_s_7.02","unknown_s_2.05_NA-group","phenylalanine","ureidopropionate","b-hydroxybutyrate","unknown_d_6.98","unknown_m_8.335","2-oxoisovalerate","Unknown_q_5.03","pyruvate","b-aminoisobutyrate","Unknown_d_5.11","acetoacetate","nicotinate","N-acetyl groups (glycoproteins)","valine","lactate","fumarate","histidine"],"pubmed_abstract":["Type 2 diabetes mellitus is the result of a combination of impaired insulin secretion with reduced insulin sensitivity of target tissues. There are an estimated 150 million affected individuals worldwide, of whom a large proportion remains undiagnosed because of a lack of specific symptoms early in this disorder and inadequate diagnostics. In this study, NMR-based metabolomic analysis in conjunction with multivariate statistics was applied to examine the urinary metabolic changes in two rodent models of type 2 diabetes mellitus as well as unmedicated human sufferers. The db/db mouse and obese Zucker (fa/fa) rat have autosomal recessive defects in the leptin receptor gene, causing type 2 diabetes. 1H-NMR spectra of urine were used in conjunction with uni- and multivariate statistics to identify disease-related metabolic changes in these two animal models and human sufferers. This study demonstrates metabolic similarities between the three species examined, including metabolic responses associated with general systemic stress, changes in the TCA cycle, and perturbations in nucleotide metabolism and in methylamine metabolism. All three species demonstrated profound changes in nucleotide metabolism, including that of N-methylnicotinamide and N-methyl-2-pyridone-5-carboxamide, which may provide unique biomarkers for following type 2 diabetes mellitus progression."],"pubmed_title":["A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human."],"pubmed_authors":["Salek R M RM, Maguire M L ML, Bentley E E, Rubtsov D V DV, Hough T T, Cheeseman M M, Nunez D D, Sweatman B C BC, Haselden J N JN, Cox R D RD, Connor S C SC, Griffin J L JL"],"name_synonyms":["T2DM - Type 2 Diabetes mellitus, Adult-Onset Diabetes Mellitus, Controlling, preventive therapy, human being, grupo, Noninsulin Dependent, Modern, Metabonomic, MODY, Type 2 Diabetes Mellitus, Metabonomics, DIABETES MELLITUS TYPE 02, diabetes mellitus type 2, prevention, Human, Adult-Onset, T2D, Homo sapiens, Adult-Onset Diabetes, Non-Insulin-Dependent, Maturity-Onset, Slow-Onset Diabetes Mellitus, Non-Insulin Dependent Diabetes Mellitus, Maturity Onset Diabetes, 2, group., Type 2 Diabetes Mellitus Non-Insulin Dependent, non-insulin-dependent diabetes mellitus, Ketosis Resistant, Metabolomic, Slow Onset, prevention and control, noninsulin-dependent, Man, Maturity-Onset Diabetes Mellitus, Maturity-Onset Diabetes, T2DM, study, Type 2 Diabetes, Man (Taxonomy), reference sample, diabetes mellitus, ensemble, prophylaxis, Non-Insulin-Dependent Diabetes Mellitus, Type II Diabetes, Rest, Maturity Onset Diabetes Mellitus, Type 2, man, human, Ketosis-Resistant Diabetes Mellitus, NIDDM, preventive measures, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, set, Non-Insulin Dependent Diabetes, Noninsulin Dependent Diabetes Mellitus, Stable, control, grupos, Diabetes Mellitus, Modern Man, Ketosis-Resistant, Type II, Non Insulin Dependent, Slow-Onset, Diabetes, Stable Diabetes Mellitus, groupe, Maturity Onset, Controlled, Gruppe, Adult Onset"],"description_synonyms":["Modb1, Soluble, Adult-Onset Diabetes Mellitus, Insulin B Chain, Food Patterns, determination, Blood, Mbp1, Metabonomic, Type 2 Diabetes Mellitus, insuline humaine, Metabonomics, diabetes mellitus type 2, prevention, inadequate, dysfunctional, School-Age, Blood sugar, diseases, human insulin, Associations, symptoms, Non-Insulin Dependent Diabetes Mellitus, Maturity Onset Diabetes, 2, diseases and disorders, myd, Fs(3)Hor, Leprb, Slow Onset, prevention and control, DM - Diabetes mellitus, insulin, DmelCG2684, human disease, Man (Taxonomy), reference sample, proportionality to, Tissue, hypoplasia, Mbp-1, Statistic, NTef2, Estimated, Ketosis-Resistant Diabetes Mellitus, NIDDM, Food, allergic reaction, preventive measures, Noninsulin-Dependent, set, Secretion, insulin human, Diabetes mellitus, Homo sapiens disease, Non Insulin Dependent, db, insulinum humanum, screening, Regular, preventive therapy, PLATEST, DM, gyltl1b-b, Modern, partial functionality, Fs(3)Sz11, Regular Insulin, Adult-Onset, OB-RGRP, insulin (recombinant), Adult-Onset Diabetes, MDDGA6, School Age, mKIAA0609, NOS, Ketosis Resistant, KIAA0609, Soluble Insulin, Maturity-Onset Diabetes Mellitus, fg, Blood Sugar, Populations, gyltl1b, mdc1d, proportionality, Type II Diabetes, insulina humana, expanded, signs, rate, Type 2, lacks function of type, human, low functionality, early, Obr, Diabetes NOS, Noninsulin-Dependent Diabetes Mellitus, MDC1D, disease, Non-Insulin Dependent Diabetes, enr, Dietary Patterns, Specificity and Sensitivity, enlarged, Patient, Blood Glucose, Horka, CG2684, Fs(3)Horka, School-Age Population, obl, Slow-Onset, Platelets, Gruppe, T2DM - Type 2 Diabetes mellitus, big, other disease, criteria, human being, Glucose, Noninsulin Dependent, impaired, Insulin B, DIABETES MELLITUS TYPE 02, guidelines, Patterns, froggy, Gyltl1a, Human, large, reduced, Homo sapiens, sensitive, Insulin, Non-Insulin-Dependent, Diets, Diabetes mellitus (disorder), disease or disorder, non-insulin-dependent diabetes mellitus, DmF2, tiny, Metabolomic, noninsulin-dependent, sensitivity, Man, Maturity-Onset Diabetes, lod, T2DM, Chain, study, School-Age Populations, proportion, Food Pattern, MDDGB6, Non-Insulin-Dependent Diabetes Mellitus, dysfunction, obese-like, Papers., LARGE, Maturity Onset Diabetes Mellitus, Population, man, non-neoplastic, Pattern, BPFD#36, Iletin, Noninsulin Dependent Diabetes Mellitus, Insulin recombinant, Stable, grupos, Diabetes Mellitus, Clients, great, Sensitivity, disorder, Ketosis-Resistant, School Age Population, Dietary Pattern, Diabetes, diabetes, Controlled, Adult Onset, small, Controlling, findings, grupo, disorders, MODY, medical condition, Client, group, diabetes mellitus (disease), T2D, Sodium Insulin, chemical analysis, Insulin A Chain, Maturity-Onset, Slow-Onset Diabetes Mellitus, condition, Type 2 Diabetes Mellitus Non-Insulin Dependent, Sodium, Novolin, LEPROT, Type 2 Diabetes, Exubera, diabetes mellitus, underdeveloped, ensemble, prophylaxis, Dietary, Specificity, Rest, Lds, School Age Populations, Sugar, having decreased function, control, Modern Man, quotient, assay, Type II, Stable Diabetes Mellitus, groupe, Maturity Onset"],"pubmed_abstract_synonyms":["Soluble, Adult-Onset Diabetes Mellitus, Insulin B Chain, Rat, Biological Markers, Viral Marker, Ob Gene Product, Materials, Surrogate Endpoints, determination, Laboratory, Mus domesticus, Mbp1, Metabonomic, Biochemical, Norway Rat, Endpoint, Type 2 Diabetes Mellitus, insuline humaine, Metabonomics, Serum, diabetes mellitus type 2, House Mouse, Norway Rats, methylamine metabolism, Adiposis, inadequate, dysfunctional, Obese, rat, met4PY, Laboratory Markers, unspecified, Tier, diseases, Biological, human insulin, Mammals, symptoms, Non-Insulin Dependent Diabetes Mellitus, Maturity Onset Diabetes, 2, diseases and disorders, Norway rat, myd, Fs(3)Hor, animal, Slow Onset, Maturity-Onset Diabetes., Animalia, insulin, DmelCG2684, human disease, Man (Taxonomy), proportionality to, Tissue, hypoplasia, Mbp-1, Statistic, Swiss Mice, NTef2, Estimated, Ketosis-Resistant Diabetes Mellitus, NIDDM, Laboratory Rat, allergic reaction, Noninsulin-Dependent, Secretion, insulin human, Immune, Markers, urinary aspects, Viral Markers, Homo sapiens disease, house mouse, Non Insulin Dependent, Obese Protein, insulinum humanum, screening, Regular, Viral, PLATEST, Surrogate Endpoint, gyltl1b-b, rodents, obese, animalia, Krebs cycle, Modern, N-methylnicotinamide monohydrochloride, mouse, Biochemical Markers, Rattus, Biologic Marker, partial functionality, Fs(3)Sz11, Regular Insulin, Dipodidae, Adult-Onset, insulin (recombinant), Hydrochaeri, organism, Mus norvegicus, Rattus norwegicus, Adult-Onset Diabetes, Marker, MDDGA6, mKIAA0609, Obesity [Ambiguous], Obese (finding), Diseases, Genetic Materials, Ketosis Resistant, KIAA0609, Soluble Insulin, Maturity-Onset Diabetes Mellitus, Genetic Material, fg, Mus musculus, gyltl1b, whole organism, End Points, mice, mdc1d, proportionality, Swiss Mouse, Type II Diabetes, insulina humana, expanded, signs, Adiposity, rate, OBESITY NOS, INSDC_feature:gene, Immunologic, Type 2, lacks function of type, Beaver, Laboratory Marker, rats, human, low functionality, early, domesticus, Noninsulin-Dependent Diabetes Mellitus, MDC1D, disease, Non-Insulin Dependent Diabetes, enr, Specificity and Sensitivity, enlarged, Material, Biochemical Marker, Horka, Rodentias, Koerper, CG2684, Fs(3)Horka, Cistron, Mouse, Slow-Onset, Platelets, T2DM - Type 2 Diabetes mellitus, big, other disease, human being, multi-cellular organism, norvegicus, Clinical Markers, Noninsulin Dependent, Clinical Marker, obesity disease, impaired, Capybara, Gene, Insulin B, rodent, DIABETES MELLITUS TYPE 02, Gene Product, froggy, Gyltl1a, Human, Surrogate End Points, Obesity, Surrogate Markers, large, Rattus sp. strain Wistar, Rats, reduced, Homo sapiens, House, sensitive, Insulin, Non-Insulin-Dependent, disease or disorder, Mus musculus domesticus, citric acid cycle, non-insulin-dependent diabetes mellitus, DmF2, tiny, Rattus rattiscus, Animal, Metabolomic, Mice, noninsulin-dependent, sensitivity, Man, Maturity-Onset Diabetes, lod, brown rat, T2DM, Chain, study, Biomarker, proportion, urinary levels, Rattus norvegicus, Genetic, Clinical, Swiss, nucleotide metabolism, MDDGB6, Non-Insulin-Dependent Diabetes Mellitus, dysfunction, Biological Marker, LARGE, metazoa, Maturity Onset Diabetes Mellitus, Castor Beaver, Overweight and obesity, man, non-neoplastic, BPFD#36, Iletin, Immunologic Markers, Noninsulin Dependent Diabetes Mellitus, Insulin recombinant, Stable, Diabetes Mellitus, great, Jerboas, Sensitivity, disorder, methylammonium metabolism, Ketosis-Resistant, species, Immunologic Marker, Diabetes, Biologic, Adult Onset, Rattus norvegicus8, small, methylammonium metabolic process, Hydrochaeris, findings, body, Serum Markers, disorders, MODY, End Point, whole body, medical condition, Cistrons, obesity, Immune Marker, T2D, Sodium Insulin, Mus, oxidative TCA cycle, Surrogate End Point, Laboratory Rats, chemical analysis, Metazoa, Insulin A Chain, Maturity-Onset, Slow-Onset Diabetes Mellitus, condition, Type 2 Diabetes Mellitus Non-Insulin Dependent, Sodium, Novolin, obesity disorder, Obesity (disorder), Biologic Markers, Serum Marker, Type 2 Diabetes, Exubera, N-METHYL-NICOTINAMIDE, diabetes mellitus, underdeveloped, Beavers, Surrogate, Obesity NOS, Endpoints, Specificity, ob, OB, House Mice, Rodents, Jerboa, Lds, Capybaras, Rodent, Surrogate Marker, Laboratory Mice, having decreased function, Obese Gene Product, TCA cycle, Modern Man, quotient, Ob, assay, Norway, Type II, Ob Protein, Stable Diabetes Mellitus, Laboratory Mouse, Maturity Onset, Gunn rats, Immune Markers"],"pubmed_title_synonyms":["T2DM - Type 2 Diabetes mellitus, Adult-Onset Diabetes Mellitus, Rat, human being, norvegicus, Laboratory, Noninsulin Dependent, Mus domesticus, Metabonomic, Norway Rat, Type 2 Diabetes Mellitus, Metabonomics, DIABETES MELLITUS TYPE 02, diabetes mellitus type 2, House Mouse, Norway Rats, Human, rat, Rattus sp. strain Wistar, Rats, Homo sapiens, House, Mammals, Non-Insulin-Dependent, Non-Insulin Dependent Diabetes Mellitus, Mus musculus domesticus, Maturity Onset Diabetes, 2, non-insulin-dependent diabetes mellitus, Norway rat, Rattus rattiscus, Metabolomic, Slow Onset, Mice, noninsulin-dependent, Man, Maturity-Onset Diabetes, brown rat, T2DM, Rattus norvegicus, Man (Taxonomy), Swiss, Non-Insulin-Dependent Diabetes Mellitus, Swiss Mice, Maturity Onset Diabetes Mellitus, man, Ketosis-Resistant Diabetes Mellitus, NIDDM, Laboratory Rat, Noninsulin-Dependent, Noninsulin Dependent Diabetes Mellitus, Stable, Diabetes Mellitus, Ketosis-Resistant, house mouse, Non Insulin Dependent, Diabetes, Adult Onset, Rattus norvegicus8, mouse, MODY, Modern., Rattus, Adult-Onset, Mus norvegicus, T2D, Rattus norwegicus, Adult-Onset Diabetes, Mus, Laboratory Rats, Maturity-Onset, Slow-Onset Diabetes Mellitus, Type 2 Diabetes Mellitus Non-Insulin Dependent, Ketosis Resistant, Maturity-Onset Diabetes Mellitus, Mus musculus, Type 2 Diabetes, diabetes mellitus, mice, Swiss Mouse, Type II Diabetes, House Mice, Type 2, rats, human, domesticus, Laboratory Mice, Noninsulin-Dependent Diabetes Mellitus, Non-Insulin Dependent Diabetes, Modern Man, Mouse, Norway, Type II, Slow-Onset, Stable Diabetes Mellitus, Laboratory Mouse, Maturity Onset, Gunn rats"],"additional_accession":[]},"is_claimable":false,"name":"A metabolomic study of urinary changes in type 2 diabetes in human compared to the control group","description":"Type 2 diabetes mellitus is the result of a combination of impaired insulin secretion with reduced insulin sensitivity of target tissues. There are an estimated 150 million affected individuals worldwide, of whom a large proportion remains undiagnosed because of a lack of specific symptoms early in this disorder and inadequate diagnostics. In this study, NMR-based metabolomic analysis in conjunction with uni- and multivariate statistics was applied to examine the urinary metabolic changes in Human type 2 diabetes mellitus patients compared to the control group. The human population were un medicated diabetic patients who have good daily dietary control over their blood glucose concentrations by following the guidelines on diet issued by the American Diabetes Association. Note: This is part of a larger study, please refer to the original paper below.","dates":{"publication":"2012-02-14","submission":"2012-02-14"},"accession":"MTBLS1","cross_references":{"MetaboLights":["MTBLC1148","MTBLC60647","MTBLC24898","MTBLC25017","MTBLC27266","MTBLC60645","MTBLC35932","MTBLC16530","MTBLC16236","MTBLC20067","MTBLC30860","MTBLC78320","MTBLC50129","MTBLC16449","MTBLC64390","MTBLC74911","MTBLC25094","MTBLC18257","MTBLC18211","MTBLC15366","MTBLC17533","MTBLC21547","MTBLC28300","MTBLC30772","MTBLC15347","MTBLC15344","MTBLC74903","MTBLC30744","MTBLC32816","MTBLC18261","MTBLC6650","MTBLC15741","MTBLC30915","MTBLC18237","MTBLC30769","MTBLC17170","MTBLC15611","MTBLC17724","MTBLC16628","MTBLC18139","MTBLC16810","MTBLC16919","MTBLC16737","MTBLC27389","MTBLC17497","MTBLC16704","MTBLC64399","MTBLC15676","MTBLC16335","MTBLC18012","MTBLC27838","MTBLC27410","MTBLC32980","MTBLC104011","MTBLC27637","MTBLC18186","MTBLC27570","MTBLC43355","MTBLC64414","MTBLC28044","MTBLC18089","MTBLC18123","MTBLC15940","MTBLC30751"],"pubmed":["17190852"],"ChEBI":["CHEBI:1148","CHEBI:60647","CHEBI:24898","CHEBI:25017","CHEBI:27266","CHEBI:60645","CHEBI:35932","CHEBI:16530","CHEBI:16236","CHEBI:20067","CHEBI:30860","CHEBI:78320","CHEBI:50129","CHEBI:16449","CHEBI:64390","CHEBI:74911","CHEBI:25094","CHEBI:18257","CHEBI:18211","CHEBI:15366","CHEBI:17533","CHEBI:21547","CHEBI:28300","CHEBI:30772","CHEBI:15347","CHEBI:15344","CHEBI:74903","CHEBI:30744","CHEBI:32816","CHEBI:18261","CHEBI:6650","CHEBI:15741","CHEBI:30915","CHEBI:18237","CHEBI:30769","CHEBI:17170","CHEBI:15611","CHEBI:17724","CHEBI:16628","CHEBI:18139","CHEBI:16810","CHEBI:16919","CHEBI:16737","CHEBI:27389","CHEBI:17497","CHEBI:16704","CHEBI:64399","CHEBI:15676","CHEBI:16335","CHEBI:18012","CHEBI:27838","CHEBI:27410","CHEBI:32980","CHEBI:104011","CHEBI:27637","CHEBI:18186","CHEBI:27570","CHEBI:43355","CHEBI:64414","CHEBI:28044","CHEBI:18089","CHEBI:18123","CHEBI:15940","CHEBI:30751"]}}