MetaboLights

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EAT3_0h.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS10972/FILES/RAW_FILES/Sample_20_EAT8_minus_1h.rawprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS10972Metabolites were identified in IDEOM with the aid of an in house library of approximately 350 standards.MetaboLightsPublicLiquid Chromatography MS - alternating - hilicUsing a Dionex RSLC3000 UHPLC.  ZIC-p(HILIC) column (5 µm, 150 x 4.6 mm) with a ZIC-pHILIC guard column (20 x 2.1 mm) (both Merck Millipore, Australia). A gradient elution of 20 mM ammonium carbonate (A) and acetonitrile (B) (linear gradient time-%B: 0 min-80%, 15 min-50%, 18 min-5%, 21 min-5%, 24 min-80%, 32 min-80%) was utilized at 25 °C, with 300 μL/min flow rate. Acute response to a high-fat-high-refined carbohydrate meal in healthy young men shows novel perturbation of multiple metabolic and defense pathways. 10.1039/d5fo04456a.Aimee DordevicChristopher K BarlowMonash Universityblood plasmasolventmass spectrometry assayPlasma was thawed on ice before adding 25 µL to 200 µL of ice-cold extraction solvent (1:1 acetonitrile:methanol v/v, internal standards: 2 µM CHAPS, CAPS, PIPES and TRIS), followed by vortex mixing for 30 min at 4 °C before centrifugation (20,000 x g, 4 °C, 15 min). The supernatant was then immediately analysed.blankHomo sapienshttps://www.ebi.ac.uk/metabolights/MTBLS10972Aimee Dordevic. Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, Victoria, 3168, Australia. aimee.dordevic@monash.edu.Christopher Barlow. Monash Proteomics & Metabolomics FacilityPlatform, Monash Biomedicine Discovery Institute & Department of Biochemistry and Molecular Biology, Monash University, Clayton VIC 3800, Australia. chris.barlow@monash.edu.Kaitlin Day. School of Health and Biomedical Sciences, RMIT University, Bundoora VIC 3083. kaitlin.day@rmit.edu.au.Ralf Schittenhelm. Monash Proteomics & Metabolomics FacilityPlatform, Monash Biomedicine Discovery Institute & Department of Biochemistry and Molecular Biology, Monash University, Clayton VIC 3800, Australia. ralf.schittenhelm@monash.edu.Margaret Murray. Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, Victoria, 3168, Australia. margaret.murray@monash.edu.Louise Bennett. School of Chemistry, Monash University, Clayton, Victoria, 3800, Australia. louise.bennett1@monash.edu.Nina Trinquet. Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, Victoria, 3168, Australia. nina.trinquet1@monash.edu.Beau-Luke Colton. Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, Victoria, 3168, Australia. beau.colton@gmail.com.Gary Williamson. Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, Victoria, 3168, Australia. gary.williamson1@monash.edu.Michael Houghton. Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, Victoria, 3168, Australia. michael.houghton@monash.edu.Nicole Kellow. Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, Victoria, 3168, Australia. nicole.kellow@monash.edu.The mzMatch data were filtered, identified, quantified and visualised in IDEOM using default values (http://mzmatch.sourceforge.net/ideom.php).Timeaimee.dordevic@monash.educhris.barlow@monash.eduVenous blood samples for serum were collected into BD Vacutainer SSTTM II Advance tubes (North Ryde, New South Wales, Australia), allowed to clot for 30 min, centrifuged at 2.0 relative centrifugal force (RCF) for 5 min at 22-25 °C and stored at -80 °C until analysis. Venous blood samples for plasma were collected into BD Vacutainer K2EDTA Tubes (North Ryde, New South Wales, Australia) and immediately centrifuged at 1.5 RCF for 10 min at 4 °C and stored at -80 °C until analysis. Plasma aliquots had 20 µL of ethylenediamine tetraacetic acid (EDTA) (0.1% w/v) and ascorbic acid (20% w/v) added per 500 µL, and then were stored at -80 °C.Metabolomicsblankblood plasmauntargeted analysisThermo Scientific Dionex UltiMate 3000 RSLC SystemdigestionHomo sapienssolventFood & Nutritionhigh fatTermo Scientific Q Exactive Plusblankblood plasmauntargeted analysisThermo Scientific Dionex UltiMate 3000 RSLC SystemdigestionHomo sapienssolventFood & Nutritionhigh fatTermo Scientific Q Exactive PlusQ-Exactive Plus Orbitrap MS (Thermo). MS was performed at 70,000 resolution operating in rapid switching positive (4 kV) and negative (-3.5 kV) mode electrospray ionization (capillary temperature 300 °C; sheath gas flow rate 50; auxiliary gas flow rate 20; sweep gas 2; probe temp 120 °C).alpha-IroneProstaglandin G2L-OctanoylcarnitineL-PipecolateTributyl phosphateN-Acetyl-L-histidineConiferyl alcoholEctoineL-2,4-DiaminobutanoateN5-Methyl-L-glutamineL-ErythruloseL-HistidineL-2-Amino-6-oxoheptanedioateN-(omega)-HydroxyarginineTetracosanoic acidD-GlycerateBile saltL-Proline[ST (4:0)] 5alpha-Cholane-3alpha,7alpha,12alpha,24-tetrolMethylitaconate[FA trihydroxy(4:0)] 2,3,4-trihydroxy-butanoic acidMethylimidazole acetaldehyde(2S,3S)-2-Hydroxytridecane-1,2,3-tricarboxylateN2-(D-1-Carboxyethyl)-L-lysine(S)-3-Methyl-2-oxopentanoic acidPicolinamideQuinalphosN2-Succinyl-L-ornithine3-beta-D-Galactosyl-sn-glycerolL-3-Amino-isobutanoateL-AsparagineN6-Acetyl-L-lysineN6-(L-1,3-Dicarboxypropyl)-L-lysineTetrapentylammoniumN(alpha)-gamma-L-Glutamylhistamine4-Methylene-L-glutamine3-Hydroxy-2-methylpyridine-4,5-dicarboxylateN-Amidino-L-aspartate[FA (4:0)] 3-butenoic acidFA (8:0) octanoic acidN-(3-acetamidopropyl)-4-aminobutanalFA (12:1) dodecenoic acidOrotate(Fragment)5,6-DihydrothymineVindolineN-(6-Aminohexanoyl)-6-aminohexanoateSinapyl alcoholCitrate(S)-MalateL-OrnithineADPGlycerophosphoglycerolRibulosePhenyllactateN-[(E,E)-Piperoyl]piperidine8-Amino-7-oxononanoateTrimetaphosphate(E)-3,7-Dimethylocta-1,6-diene-3,8-diol(S)-1-Pyrroline-5-carboxylate(R)-3-Hydroxybutanoate3-methylthiopropanalD-GalacturonateL-Aspartate 4-semialdehyde(+)-gamma-Hydroxy-L-homoarginineUrsodiolD-Methioninecis-AconitateAnisoleN-Acetyl-D-quinovosamineD-Gluconic acid3-Hydroxy-2-methylpyridine-5-carboxylateD-GlucoseDecanoic acid4,5-DioxopentanoateIndolegamma-L-Glutamyl-D-alanine2(alpha-D-Mannosyl)-D-glycerate(R)-2-HydroxyglutarateTris(butoxyethyl)phosphateL-Carnitine(R)-3-Amino-2-methylpropanoate3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanateDiethanolamineCerulenin4-Methyl-2-oxopentanoate[ST (3:0)] (5Z,7E)-(1S,3R)-9,10-seco-5,7,10(19)-cholestatriene-1,3,25-triol(S)-3-Hydroxyisobutyrate2-C-Methyl-D-erythritol 4-phosphateAdenosineN(alpha)-Benzyloxycarbonyl-L-leucineIndolepyruvateN-Acetyl-D-phenylalanine3-(Pyrazol-1-yl)-L-alanine5-Dehydro-4-deoxy-D-glucarateL-TyrosineN-Formimino-L-glutamateN-Acetyl-D-glucosaminateAldicarb(S)-2-Acetolactate5-Oxo-D-prolineS-Carboxymethyl-L-cysteineHypotaurinePhenylhydrazineL-RhamnoseN-Acetylneuraminate(S)-LactateL-PhenylalanineSucrose[FA hydroxy(12:0)] 3-hydroxy-dodecanoic acidL-2-HydroxyphytanateN-Butyryl-L-homoserine lactonebeta-CymaropyranoseTraumatic acidErythritolFA (17:0)(-)-Jasmonic acidTriethylamine1(2H)-Isoquinolinone3-Dehydrocarnitine2,5-Dioxopentanoate4-Hydroxybutanoic acidThien-2-ylacetate5-AminolevulinateMethylenediureaN4-(Acetyl-beta-D-glucosaminyl)asparagineIsonicotineamideDiisononyl phthalateSulfoacetateAcetone cyanohydrin(24R,24'R)-Fucosterol epoxide4-NitroanilineSuberic acid2-Oxobutanoate5-Methylcytidine2-Quinolinecarboxylic acid[ST (2:0)] 5beta-Cholestane-3alpha,7alpha-diolO-Palmitoyl-R-carnitine4-Hydroxyphenylacetate3-MethoxyanthranilateFA hydroxy(12:0) dodecanoic acidL-Carnitinamidegamma-Amino-gamma-cyanobutanoate4-(Trimethylammonio)but-2-enoateN-(11Z-eicosaenoyl)-ethanolaminePalmitoylglycerone phosphateD-GalactoseCreatinineD-ThreoseGuanidinoacetateD-XylonateHydroxypyruvatetrans-Cinnamoyl beta-D-glucoside5-Methylthio-D-ribose2-PhenylacetamideO-Propanoylcarnitine(3Z)-Phytochromobilin2-Hydroxymalonate[ST hydrox] 3beta-hydroxypregn-5-ene-20-one6-endo-Hydroxycineole2-OxoglutaratePhenylacetonitrile4-AminosalicylateIsothebaineN4-AcetylaminobutanalBilirubinFA hydroxy(20:4) eicosatetraenoic acidO-Acetylneuraminic acid3-(2-Hydroxyphenyl)propanoateHippurate1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamideOctadecanoic acidGlycocholatePhenylpropanoateBetaineL-AlaninemethionolAcetyl adenylateStachyoseN6-Acetyl-N6-hydroxy-L-lysine2-Butenoate[PR] (-)-CarvoneAMPMonomethyl sulfate3,5/4-Trihydroxycyclohexa-1,2-dioneL-Methionine S-oxideDehydrovomifoliolLysoPC(18:1)S-Methylthioglycolate15,16-DihydrobiliverdinIsoquinolineN-AcetylanthranilateL-LysineL-Glutamate1,6,6-Trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one[FA oxo(14:0)] 3-oxo-tetradecanoic acidEcgonine methyl esterItaconateCys-GlyNalpha-Methylhistidine6-Amino-2-oxohexanoate3-Methylbutanol3-Methylbutanoic acidChrysenesn-glycero-3-PhosphoethanolamineDodecanoic acidCoformycinAllysine10-Hydroxydecanoic acidN-(11Z,14Z-eicosadienoyl)-ethanolamine2-Hydroxy-3-oxoadipateSphinganineGlycodeoxycholate2-OxoadipateAcetoacetateCadaverineIndolelactateThymineH2S2O3IndoxylRetinyl ester3-CresolGlycerone phosphateQuinateD-RiboseFA(16:1)4-Methylene-L-glutamateSulfateL-2-AminoadipateN2-Acetyl-L-lysineL-Aspartate[FA (18:3)] 13S-hydroperoxy-9Z,11E,14Z-octadecatrienoic acidTaurineD-FructosePhenol sulfate2-Ethylhexyl phthalate3-(4-Hydroxyphenyl)pyruvateL-a-glutamyl-L-LysineN-Methyl-2-pyrrolidinoneD-XyloseL-ThreonineN5-Ethyl-L-glutamineD-Alanyl-D-alanineGlycochenodeoxycholate 7-sulfate[FA oxo(8:0)] 3-oxo-octanoic acid[SP] Sphinganine-1-phosphate4-Hydroxy-2-oxoglutarateL-LeucineD-Sorbitol[SP] Sphing-4-enine-1-phosphateTrigonelline3-Ureidopropionate4-Hydroxyaminoquinoline N-oxideSuccinateL-UrobilinGlycerolMuramic acid[FA (6:0)] hexanalN-Acetyl-D-glucosamineBiotin amide4-Oxoproline2-Dehydro-D-xylonateAcetoacetamideIndole-3-acetaldoxime3-(4-Hydroxyphenyl)lactateCholateDopaquinone4-Pyridoxate(-)-erythro-(2R,3R)-dihydroxybutylamide[ST (18:2)] cholest-5-en-3beta-yl (9Z,12Z-octadecadienoate)S-Methyl-1-thio-D-glycerateHexadecanoic acidFA (8:1) octenalOrthophosphateIndoxylsulfate12-OPDAImidazole-4-acetate4-Hydroxyhexan-3-one[FA hydroxy(20:4)] 5S-hydroxy-12-keto-6Z,8E,10E,14Z-eicosatetraenoic acidFA (20:0)[FA trihydrox] 9S,11R,15S-trihydroxy-2,3-dinor-13E-prostaenoic acid-cyclo[8S,12R]Miserotoxin3-MethyleneoxindoleUrateL-TryptophanDocosahexaenoicacid4-Trimethylammoniobutanoate(R)-4'-Phosphopantothenoyl-L-cysteine1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(β-hydroxyethyl)-2-methylpyridinium bromide1,8-Diazacyclotetradecane-2,9-dione[FA (11:0)] undecanoic acid[FA (10:0/2:0)] Decanedioic acidN-Acetyl-beta-alanine1-Pyrroline-2-carboxylateL-ArabinosePantothenateFA (20:1)delta1-Piperideine-2-carboxylate5'-OxoinosineL-Homocitrulline[ST (4:0)] 5beta-Cholestane-3alpha,7alpha,12alpha,26-tetrolalpha-N-Phenylacetyl-L-glutamineL-Valine[ST hydrox] 3alpha-hydroxy-5alpha-androstan-17-one 3-sulfateTaurodeoxycholatemeso-2,6-Diaminoheptanedioate4-Acetamidobutanoate2-IsopropylmaleateL-KynurenineCreatineStipitatonateFA methyl(14:0)(E)-GlutaconateMethacholineAbscisate2-Hydroxy-2,4-pentadienoate4-Hydroxymandelonitrilealpha-IononeN-Hydroxy-2-acetamidofluoreneImidazolone(R)-2,3-Dihydroxy-3-methylpentanoateTetradecanoic acid4-PyridoxolactoneHypoxanthineLinamarinL-ArginineGeranyl formate3',4',5,7-Tetrahydroxy-3-methoxyflavoneNgamma-Monomethyl-L-arginine6-O-MethylnorlaudanosolineD-Glucuronate2-Oxoglutaramate2-Arachidonoylglycerol2-MethylcholineIndole-3-acetate[ST hydrox] 3alpha,7alpha-Dihydroxy-5beta-cholan-24-oic Acid3-Hydroxy-palmitic acid methyl ester3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoateN6,N6,N6-Trimethyl-L-lysinesodium dodecyl sulfateVomifoliolNalpha,Nalpha-Dimethyl-L-histidinesn-glycero-3-Phosphocholine5-HydroxypentanoateN,N-Dimethylglycine1-Pyrroline-4-hydroxy-2-carboxylateAdeninePyruvatePinidineS-Acetyldihydrolipoamide2,7-Anhydro-alpha-N-acetylneuraminic acid3-Cyano-L-alanineMesaconateL-SerineS-Methyl-L-methionine[FA (26:0)] hexacosanoic acid(Z)-4-Hydroxyphenylacetaldehyde-oxime3-Methylguanine[FA trihydroxy(2:0)] 9S,11R,15S-trihydroxy-2,3-dinor-5Z,13E-prostadienoic acid-cyclo[8S,12R]FA oxo(12:1)Imidazol-5-yl-pyruvateN-gamma-Acetyldiaminobutyrate3beta-Hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylatetrihomomethioninesn-Glycerol 3-phosphate[PR] (+)-Bornane-2,5-dione2,3,4,5-Tetrahydropyridine-2-carboxylate1-(3,4-dimethoxylphenyl)ethane-1,2-diol5-Guanidino-2-oxopentanoate3-Amino-3-(4-hydroxyphenyl)propanoateFA (14:1) tetradecenoic acidCaffeine2,6-Dioxo-6-phenylhexanoateCholesterolsulfateL-Citrulline8-OxocoformycinN-Formyl-L-methionine(-)-CamphorMaltotriose3-OxopropanoateL-MethionineMaleamate(25S)-11alpha,20,26-trihydroxyecdysone3-DehydroquinateProclavaminic acid3-Methyl-2-oxobutanoic acidTheophyllineS-Adenosyl-L-methionineErgothioneineOxalateN-Acetylisatin2-Aminobutan-4-olideI-UrobilinogenUrea-1-carboxylateN-AcetylornithineD-Nopaline2-Aminoacrylate[ST trihydroxy(2:0)] 11beta,17,21-trihydroxypregn-4-ene-3,20-dioneMannitolEcdysone3-Oxohexobarbital[FA (24:0)] 15Z-tetracosenoic acid[FA trihydroxy(20:4)] 5S,12R,20-trihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid4-Imidazolone-5-propanoateBotrydialDodecanedioic acidN-AcetylputrescineO-Acetylcarnitinetrans-Aconitate2-Hydroxybutanoic acidD-Mycinose[PA(16:0/0:0)] 1-hexadecanoyl-2-sn-glycero-3-phosphateL-GlutamineD-Glucosamine3,4-Dehydrothiomorpholine-3-carboxylateCholineN-Propanoylimidazole9S,11R-epidioxy-15S-hydroxy-5Z,13E-prostadienoic acidEthyl (R)-3-hydroxyhexanoate2-Dehydro-3-deoxy-D-glucarateN-AcetylmuramateEthyl (R)-3-hydroxybutanoateN6-Hydroxy-L-lysineN2-Acetyl-L-aminoadipateL-IsoleucineN-Acetyl-L-citrulline[FA (25:0)] pentacosanoic acid3-Oxododecanoic acid6-Acetamido-3-aminohexanoate6-OxocineoleD-RibuloseI-UrobilinCholine phosphate7-Methylxanthinep-BenzenediolIndoleacrylicacidN6-(1,2-Dicarboxyethyl)-AMPD-ArabinonateD-ArabitolSedoheptulosebeta-D-Fructose[FA hydroxy(14:0)] 3S-hydroxy-tetradecanoic acidCDP-cholineL-Dehydroascorbate2-MethylcitrateButanoic acidFA (20:4)RaffinoseO-Acetyl-L-homoserine[FA (23:0)] tricosanoic acid[FA (22:4)] 7Z,10Z,13Z,16Z-docosatetraenoic acidSuccinate semialdehydeUrocanate3beta-Hydroxyandrost-5-en-17-one 3-sulfateBendiocarbPiperidinealpha-D-Glucose2-AcetolactateN-Acetyl-L-glutamateN-Acetyl-L-leucineL-Azetidine 2-carboxylic acidFA oxo(10:0)Dethiobiotin3-oxohexacosanoic acidEthyl 3-oxohexanoatePhosphocreatineBenzyl (2R,3S)-2-methyl-3-hydroxybutanoateN2-(D-1-Carboxyethyl)-L-arginine3-Hydroxy-N6,N6,N6-trimethyl-L-lysineLactoseN(pi)-Methyl-L-histidineCarbamoyl phosphateBethanecholfalseAcute response to a high-saturated, high-refined carbohydrate meal in healthy young men shows novel perturbation of multiple metabolic and defense pathwaysRegular consumption of fat and refined carbohydrates induces metabolic stress, increasing chronic metabolic disease risk. In healthy volunteers, we characterised the response to a high-fat/high-carbohydrate meal (HFHCM), typical of an ultra-processed food, by proteomic and metabolomics analyses, to define the postcibalome. Glucose, fructose, galactose, insulin and myeloperoxidase transiently increased; 220 plasma proteins (~17% “cellular oxidant detoxification”) were transiently decreased at 240 and 300 min coinciding with undigested HFHCM components reaching the gut microbiota. Superoxide dismutase-1, a key antioxidant enzyme, was confirmed measured using ELISA, and maximal decreases were predicted by individual plasma glucose AUC. Elevated amino acids at 6 h matched those proposed to be fasting indicators of diabetes-risk; unsaturated free fatty acids decreased, whereas saturated forms increased as exemplified by octanoic acid, a modifier of ghrelin function. We propose that the magnitude of the postprandial increase in oxidative stress parameters could reflect a molecular diagnosis of metabolic health.2026-04-022026-04-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:5903CHEBI:1969CHEBI:6258CHEBI:3858CHEBI:2472CHEBI:2356CHEBI:86CHEBI:13CHEBI:17007CHEBI:20607CHEBI:2342CHEBI:7350CHEBI:85CHEBI:2228CHEBI:552CHEBI:3109CHEBI:31529CHEBI:6470CHEBI:4457CHEBI:2239CHEBI:276CHEBI:37157CHEBI:9071CHEBI:8940CHEBI:7701CHEBI:4347CHEBI:702CHEBI:1276CHEBI:7206CHEBI:5905CHEBI:5916CHEBI:6310CHEBI:7145CHEBI:34556CHEBI:2324CHEBI:9158CHEBI:55458CHEBI:3810CHEBI:960CHEBI:31648CHEBI:7212CHEBI:7214CHEBI:7672CHEBI:7406CHEBI:4216CHEBI:9837CHEBI:32368CHEBI:5917CHEBI:958CHEBI:1643CHEBI:8712CHEBI:2405CHEBI:3050CHEBI:29552CHEBI:95CHEBI:19144CHEBI:545687CHEBI:7385CHEBI:562CHEBI:6353CHEBI:9314CHEBI:37162CHEBI:1635CHEBI:4676CHEBI:328CHEBI:7092CHEBI:23863CHEBI:36211CHEBI:36206CHEBI:23872CHEBI:35019CHEBI:10317CHEBI:4372CHEBI:32319CHEBI:10020CHEBI:15797CHEBI:7405CHEBI:7064CHEBI:10284CHEBI:3268CHEBI:37271CHEBI:37270CHEBI:7056CHEBI:37374CHEBI:7294CHEBI:10721CHEBI:2365CHEBI:8946CHEBI:6279CHEBI:39251CHEBI:1319CHEBI:1094CHEBI:190CHEBI:7897CHEBI:7896CHEBI:7348CHEBI:2223CHEBI:3159CHEBI:32366CHEBI:29479CHEBI:34639CHEBI:148CHEBI:265CHEBI:34230CHEBI:8771CHEBI:6672CHEBI:34229CHEBI:25631CHEBI:9225CHEBI:9221CHEBI:35038CHEBI:9222CHEBI:6066CHEBI:1724CHEBI:7900CHEBI:15799CHEBI:16179CHEBI:742CHEBI:2799CHEBI:6421CHEBI:1293CHEBI:8520CHEBI:8519CHEBI:32419CHEBI:2798CHEBI:6164CHEBI:35009CHEBI:3893CHEBI:8388CHEBI:4673CHEBI:53487CHEBI:300585CHEBI:364878CHEBI:34261CHEBI:6281CHEBI:39419CHEBI:1703CHEBI:3588CHEBI:9907CHEBI:3098CHEBI:1694CHEBI:9248CHEBI:50108CHEBI:7526CHEBI:6458CHEBI:9988CHEBI:39420CHEBI:35459CHEBI:5465CHEBI:5464CHEBI:52031CHEBI:9410CHEBI:52421CHEBI:581967CHEBI:31013CHEBI:3307CHEBI:4741CHEBI:46739CHEBI:41321CHEBI:1698CHEBI:1708CHEBI:1692CHEBI:177CHEBI:1719CHEBI:7811CHEBI:9889CHEBI:34987CHEBI:5839CHEBI:9406CHEBI:3099CHEBI:225CHEBI:757CHEBI:5843CHEBI:5844CHEBI:6319CHEBI:2083CHEBI:8685CHEBI:1651CHEBI:5813CHEBI:1163CHEBI:1013CHEBI:8966CHEBI:422CHEBI:4187CHEBI:5560CHEBI:6171CHEBI:6301CHEBI:5454CHEBI:10790CHEBI:5448CHEBI:10648CHEBI:46903CHEBI:6154CHEBI:8145CHEBI:4840CHEBI:49019CHEBI:4519CHEBI:7787CHEBI:6652CHEBI:1477CHEBI:35900CHEBI:1027CHEBI:2391CHEBI:9305CHEBI:1250CHEBI:9304CHEBI:423CHEBI:3910CHEBI:2399CHEBI:6198CHEBI:2390CHEBI:1017CHEBI:6194CHEBI:6193CHEBI:6191CHEBI:1671CHEBI:30772CHEBI:1516CHEBI:322CHEBI:1860CHEBI:1148CHEBI:8963CHEBI:4255CHEBI:6214CHEBI:9573CHEBI:49017CHEBI:3909CHEBI:7077CHEBI:320CHEBI:6167CHEBI:132CHEBI:6308CHEBI:6227CHEBI:4047CHEBI:28484CHEBI:2080CHEBI:4241CHEBI:6181CHEBI:4265CHEBI:4233CHEBI:8850CHEBI:4101CHEBI:4262CHEBI:8238CHEBI:6321CHEBI:17750CHEBI:4215CHEBI:6271CHEBI:6272CHEBI:6280CHEBI:1597CHEBI:4105CHEBI:3665CHEBI:1030CHEBI:3288CHEBI:3667CHEBI:10647CHEBI:5841CHEBI:9885CHEBI:2470CHEBI:9580CHEBI:5875CHEBI:1113CHEBI:938CHEBI:280CHEBI:1747CHEBI:19700CHEBI:6074CHEBI:1253CHEBI:1838CHEBI:683CHEBI:371CHEBI:1370CHEBI:2112CHEBI:1923CHEBI:684CHEBI:1252CHEBI:1998CHEBI:10558CHEBI:1584CHEBI:983CHEBI:374CHEBI:310CHEBI:1069CHEBI:7245CHEBI:7307CHEBI:6286CHEBI:2034CHEBI:7186CHEBI:6224CHEBI:8954CHEBI:4756CHEBI:1900CHEBI:7274CHEBI:401CHEBI:1891CHEBI:4178CHEBI:4153CHEBI:2060CHEBI:6284CHEBI:7386CHEBI:1777CHEBI:2605CHEBI:2170CHEBI:7279CHEBI:7667CHEBI:6161CHEBI:7351CHEBI:7399CHEBI:4088CHEBI:1901CHEBI:1866CHEBI:4889CHEBI:306CHEBI:2101CHEBI:6292CHEBI:4139CHEBI:4167CHEBI:4118CHEBI:10373CHEBI:10242CHEBI:4157CHEBI:6203CHEBI:6255CHEBI:6260CHEBI:8965CHEBI:4162CHEBI:7222CHEBI:6264CHEBI:7416CHEBI:6185CHEBI:7101CHEBI:4246CHEBI:6686CHEBI:35026CHEBI:1202CHEBI:5457CHEBI:8200CHEBI:6031CHEBI:9899CHEBI:1910CHEBI:5871CHEBI:48991CHEBI:5793CHEBI:9540CHEBI:8072CHEBI:10719CHEBI:10482CHEBI:6210CHEBI:1604CHEBI:8099CHEBI:19063CHEBI:7335CHEBI:1886CHEBI:6878CHEBI:1247CHEBI:1411CHEBI:1122CHEBI:2048CHEBI:1058CHEBI:3727CHEBI:6240CHEBI:1440CHEBI:10539CHEBI:865CHEBI:1899CHEBI:1179CHEBI:1487CHEBI:10860CHEBI:7464CHEBI:7067CHEBI:6159CHEBI:7150CHEBI:8715CHEBI:1774CHEBI:1485CHEBI:2555CHEBI:7397CHEBI:7368CHEBI:10598CHEBI:10366CHEBI:9080CHEBI:6244CHEBI:1941CHEBI:3424CHEBI:3084CHEBI:6201CHEBI:7547CHEBI:58CHEBI:1789CHEBI:1519CHEBI:9523CHEBI:2736CHEBI:1476CHEBI:7320CHEBI:3295CHEBI:7153CHEBI:7461CHEBI:29643CHEBI:31885CHEBI:8437CHEBI:10569CHEBI:546196CHEBI:4894CHEBI:44680CHEBI:9300CHEBI:49001CHEBI:7154CHEBI:59277CHEBI:506227CHEBI:7122CHEBI:2164CHEBI:31888CHEBI:7409CHEBI:7411CHEBI:3373CHEBI:4890CHEBI:29568CHEBI:6804CHEBI:50711CHEBI:10646CHEBI:25979CHEBI:5900CHEBI:5919CHEBI:1870CHEBI:1929CHEBI:5895CHEBI:1518CHEBI:1874CHEBI:1264CHEBI:454CHEBI:1578CHEBI:1928CHEBI:8103CHEBI:1422CHEBI:32978CHEBI:1430CHEBI:6282CHEBI:6313CHEBI:1450CHEBI:4828CHEBI:7375CHEBI:851CHEBI:8217CHEBI:2308CHEBI:7669CHEBI:7916CHEBI:7027CHEBI:6951CHEBI:51051CHEBI:7367CHEBI:7366CHEBI:5259CHEBI:7402CHEBI:1532CHEBI:9273CHEBI:6051CHEBI:471CHEBI:1601CHEBI:1855CHEBI:1431CHEBI:7194CHEBI:5725CHEBI:4699CHEBI:3389CHEBI:6982CHEBI:5587CHEBI:9335CHEBI:7793CHEBI:9726