Differential metabolites were identified based on the variable importance in projection (VIP) values from the OPLS-DA model and Students t-test (P<0.05). Metabolites with VIP>1 and P<0.05 were considered significantly differential. Pathway analysis of differential metabolites was performed using the KEGG database, and pathway enrichment was carried out using Fishers exact test via the Python package scipy.stats.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - negative - reverse phase","Liquid Chromatography MS - positive - reverse phase"],"chromatography_protocol":["Analyses were performed by Majorbio Bio-Pharm Technology Co. Ltd. (Shanghai, China) using a Thermo Scientific Vanquish UHPLC System and an ACQUITY UPLC HSS T3 (1.8 µm, 2.1 mm x 100 mm; Waters) column. The mobile phases were: solvent A (0.1% formic acid in water: acetonitrile, 95:5, v/v) and solvent B (0.1% formic acid in acetonitrile: isopropanol: water, 47.5:47.5:5, v/v). The flow rate was 0.40 mL/min, and the column temperature was maintained at 40°C
"],"publication":["Lactobacillus Aerosol Regulates Tryptophan Metabolism Activates AHR/SOCS3 Inhibits JAK2/STAT3 Pathway and Alleviates Inflammatory Response in broilers."],"submitter_name":["qiang niu","zhonghua yuan"],"submitter_affiliation":["Northwest A&F University"],"organism_part":["blood serum"],"technology_type":["mass spectrometry"],"disease":[""],"extraction_protocol":["Plasma samples (100 L) were mixed with 400 L of extraction solution (acetonitrile:methanol = 1:1) containing 0.02 mg/mL of internal standard (L-2-chlorophenylalanine). The mixture was subjected to low-temperature ultrasonic extraction for 30 minutes (5C, 40 kHz), followed by incubation at -20C for 30 minutes. After centrifugation for 15 minutes, the supernatant was removed, dried under nitrogen, and re-dissolved in 100 L of re-solution (acetonitrile:water = 1:1). A second round of low-temperature ultrasonic extraction was performed for 5 minutes (5C, 40 kHz), followed by centrifugation for 10 minutes. The final supernatant was transferred to an injection vial for LC-MS analysis.
"],"organism":["Gallus gallus"],"data_transformation_protocol":["The LC-MS raw data were processed using Progenesis QI (Waters Corporation, Milford, USA) for baseline filtering, peak identification, integration, retention time correction, and peak alignment, resulting in a data matrix of retention time, mass-to-charge ratio, and peak intensity. The MS and MS/MS data were matched against the HMDB, Metlin, and the self-built library of Majorbio to identify metabolites. The raw data were uploaded to the Majorbio cloud platform (cloud.majorbio.com) for preprocessing.
"],"study_factor":["Body weight","Sex","Performance"],"submitter_email":["Niuqiang@Nwafu.edu.cn","2579685526@qq.com"],"metabolights_link":["https://www.ebi.ac.uk/metabolights/MTBLS12390"],"sample_collection_protocol":["Twenty high-weight broilers (>3.1 kg, n=10) and twenty low-weight broilers (<2.7 kg, n=10), aged 42 days, were obtained from the broiler breeding facility of Shaanxi Haobang Food Co., Ltd. Blood was collected from the wing veins of broilers, transferred into anticoagulant tubes, and centrifuged at 3,000 rpm for 10 minutes at a low temperature to separate plasma for untargeted metabolomic sequencing.
"],"omics_type":["Metabolomics"],"study_design":["lung microbiota","untargeted metabolites","Serum","Lactobacillus aerosolization","Gallus gallus"],"curator_keywords":["lung microbiota","untargeted metabolites","Serum","Lactobacillus aerosolization","Gallus gallus"],"mass_spectrometry_protocol":["The UPLC system was coupled to a Thermo Scientific Q Exactive HF-X Mass Spectrometer equipped with an electrospray ionization (ESI) source operating in positive mode and negative mode. The settings were as follows: source temperature 400 °C; sheath gas flow rate 40 arb; auxiliary gas flow rate 10 arb; ion spray voltage floating (ISVF) −2800 V (negative mode) and 3500 V (positive mode); normalized collision energy (NCE): 20-40-60 V; full MS resolution: 70,000; MS/MS resolution: 17,500. Data acquisition was carried out in data-dependent acquisition (DDA) mode, with a scan range of 70–1050 m/z.
"],"metabolite_name":["9,10-DHOME","1-Nonadecanoyl-glycero-3-phosphoethanolamine","4-Hydroxynonenal","Oct-5-enedioylcarnitine","P-Coumaraldehyde","P-CHLOROPHENYLALANINE","Butyryl trihexyl citrate","Aspartame","Ethylenediaminetetraacetic acid","4'-Aminoacetanilide","Morpholine-4-carboxamide","Cladinose","2-(2-Butoxyethoxy)ethyl acetate","L-Histidine","Chlorobenzene","LysoPC(0:0/18:2(9Z,12Z))","Triticonazole","Tyrosylhydroxyproline","17alpha-Trenbolone","Hydroxyethyl methacrylic acid","Gibberellin A51-catabolite","6-Hydroxyhexanoic acid","1-O-Hexadecyl-2-arachidonoyl-sn-glycero-3-phosphocholine","Tropinone","Alpha-Bisabolol oxide B","Alpha-Bisabolol oxide A","L-Prolinamide, 5-oxo-L-prolyl-L-norvalyl-","L-Proline","4,8-Dimethylquinoline","Laminine","Azvudine","2-Methylbutyroylcarnitine","Ampicillin","N-Methylisoleucine","Ethotoin","5-Hydroxyindoleacetic acid","Indisulam","N2-Acetylornithine","Mpomeovt","Ubiquinol-8","Triacetic acid","Nevanimibe","Pantothenic Acid","2-Ethylphenol","(+/-)-Tryptophan","N6-Acetyl-L-lysine","Phenylalanylhydroxyproline","Glutaric acid","2-Hydroxyquinoline","Propoxycaine","Taurohyocholate","Estriol","4-Piperidinone, 1-hydroxy-2,2,6,6-tetramethyl-","Propafenone","4-Propylphenol","2H-Pyran-2-one, tetrahydro-4-hydroxy-4-methyl-, (R)-","3alpha-Androstanediol glucuronide","PC(20:2(11Z,14Z)/18:4(6Z,9Z,12Z,15Z))","Gamma-Glutamyltyrosine","Leucylleucine","Lactucin","3-(L-Menthoxy)-2-methylpropane-1,2-diol","Ethyl-4-hydroxymethyl-3(2H)-Furanone","Pentazocine","LysoPC(18:0/0:0)","P-Coumaric Acid","LysoPC(14:0/0:0)","N-Acetylcadaverine","DG(18:0/18:2(9Z,12Z)/0:0)","Trans-4-Hydroxy-L-proline","Isoferulic acid","N,N-Dimethyldodecylamine-N-oxide","Oleamide","PE(18:4(6Z,9Z,12Z,15Z)/P-18:1(11Z))","DG(18:1(9Z)-O(12,13)/0:0/i-18:0)","3-Hydroxydodecanedioic acid","PE(16:0/0:0)","Golotimod","Citral propylene glycol acetal","Erucic acid","1-Palmitoylphosphatidylcholine","Shikimic acid","Indole-3-acetic Acid","2-[(4-ETHOXYPHENYL)METHYLENE]-3,4-DIHYDRO-1(2H)-NAPHTHALENONE","Carisbamate","5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone","Tetradecanol","Avenestergenin B2","Hydroxylated lecithin","(+/-)-Hydroxycitronellol","N-(3-{1-[4-(3,4-Difluorophenoxy)benzyl]-4-piperidinyl}-4-methylphenyl)-2-methylpropanamide","4-Hydroxy-3-polyprenylbenzoate","3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole","Aminoadipic acid","PC(18:2(9Z,12Z)/16:0)","1-(2-Furyl)butan-3-one","15-hydroxyicosanoic acid","2-Cyclohexen-1-one","Fenvalerate","1-Hydroxy-2,2,5,5-tetramethylpyrrolidine-3-carboxylic acid","Betamethasone 17 Valerate","6-(2,6-Dimethoxypyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydrophenanthridin-2-ol","LysoPC(20:3(5Z,8Z,11Z)/0:0)","Curdione","Indole","Contignasterol","Geranylcitronellol","Methylprednisolone acetate","Monopalmitin","Isoketocamphoric acid","MG(a-15:0/0:0/0:0)[rac]","Isocitric acid","2(R)-hydroxydocosanoic acid","Pyridinoline","1,6-Bis(cyclohexyloximinocarbonyl)hexane","Tigloidine","3-Methyloxindole","Sphingosine-1-phosphate","L-Carnitine","2-Hydroxynevirapine","Sulfasalazine","3-Nitrotyrosine","Cerulenin","(2S)-2-Cyclopentyl-2-[4-[(2,4-dimethylpyrido[2,3-b]indol-9-yl)methyl]phenyl]-N-[(1S)-2-hydroxy-1-phenylethyl]acetamide","Valylphenylalanine","Jacarandic acid","3-Deoxyestrone","L-Valine, N-(2-hydroxy-3-butenyl)-","Propoxur","Isobutylidene","Suberylglycine","(S)-2-Aceto-2-hydroxybutanoic acid","Indolepyruvate","Pro Thr","2-Hydroxycinnamic acid","N-Methyl-L-Threonine","L-Tyrosine","PC(18:0/20:4(8Z,11Z,14Z,17Z))","Coniferyl Alcohol","PC(16:0/18:2(9Z,12Z))","PE(16:0/20:4(8Z,11Z,14Z,17Z))","4-Amino-5-oxopentanamide","2-Hydroxydecanedioic acid","Uric Acid","1-Naphthylamine","4-Methyl-1H-Benzotriazole","Propham","Dimethyl Phthalate","3-Hexen-1-ol","PC(18:0/18:3(9Z,12Z,15Z))","N-Valylphenylalanine","Alpha-Methylstyrene","L-quinate","LysoPC(20:2(11Z,14Z)/0:0)","L-Phenylalanine","Chembl4238926","Stearidonic acid","Traumatic acid","Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-Furanone","DG(18:0/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15)/0:0)","Glutathione episulfonium ion","Alanyltryptophan","D-Glucaro-1,4-lactone","Glycylproline","PC(20:2(11Z,14Z)/16:1(9Z))","N-(5-acetamidopentyl)acetamide","4-Trimethylammoniobutanoic acid","2,4-Hexadienyl propionate","(2S)-2-Hydroxyoctadecanoylcarnitine","Sphingosine","2-Hydroxyfelbamate","Phytanic acid","Acetyl-DL-Leucine","Isokobusone","Adenosine, 8-(butylamino)-N-cyclopentyl-","(S)-10,16-Dihydroxyhexadecanoic acid","PC(20:4(8Z,11Z,14Z,17Z)/20:2(11Z,14Z))","Taurocholic acid","LysoPE(20:4(5Z,8Z,11Z,14Z)/0:0)","LysoPC(18:1(11Z)/0:0)","Methenamine","(+)-Dehydrovomifoliol","Dimboa glucoside","Chloropentafluoroethane","Propionylcarnitine","Non-5-enoylcarnitine","Ascorbic Acid","(Z)-7-[(1R,2R,3R,5S)-2-(1,2-Dihydroxy-3-oxooctyl)-3,5-dihydroxycyclopentyl]hept-5-enoic acid","Cholylasparagine","N-Formyl-L-aspartate","2-Methyl-3-furanthiol","Cabergoline","Prostavasin","Cenisertib","3a-Methyl-2,3,4,5,5a,10,10a,10b-octahydro-1H-cyclopenta[a]fluorene-2,3,7-triol","Ethyl (S)-3-hydroxybutyrate glucoside","Gamma-Glutamylvaline","LysoPC(16:1(9Z)/0:0)","Prenyl glucoside","PC(18:3(9Z,12Z,15Z)/16:0)","Bisacurone epoxide","(9R,10S,12Z)-9,10-Dihydroxy-8-oxo-12-octadecenoic acid","Guanine","PE(18:0/20:4(8Z,11Z,14Z,17Z))","Serratol","5'-Methylthioadenosine","Benzoic Acid","LysoPE(22:4(7Z,10Z,13Z,16Z)/0:0)","Estra-1,3,5(10),7-tetraene-3,17alpha-diol","PC(18:0/18:2(9Z,12Z))","Tyrosyl-Valine","LL-2,6-Diaminopimelic Acid","LysoPC(0:0/18:1(9Z))","Phenmetrazine","D-Galactose","Indole-3-Carboxaldehyde","Dioctyl sebacate","1-O-Isopentyl-3-O-octadec-2-enoyl glycerol","Plastoquinone","ALA-ILE","4-Vinylcyclohexene","Pc(18:0/0:0)","N-Linoleoyl Histidine","Citric acid","1,2-Dihydronaphthalene-1,2-diol","5-Hydroxypentanoic acid","CDP-DG(LTE4/a-21:0)","5-Aminopentanoic acid","Ethyl 3-mercaptobutyrate","Nonylurea","5'-Deoxy-5-fluorocytidine","Diethylamino nonanoate","5-Hydroxydec-7-enoylcarnitine","Monopropionylcadaverine","L-Hexanoylcarnitine","Glycyl-leucine","Dihydrobiopterin","Tanacetol B","N-ethylmaleimide","Taurohyocholic Acid","Dioctyl Phthalate","3,8-Dihydroxy-1-methylanthraquinone-2-carboxylic acid","Indigo Carmine","Isoleucyl-Glutamate","Dialdehyde","Theobromine","Deoxycholyltyrosine","4-Pyridoxic Acid","1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamide","Cinobufagin","Zingerone","1-cyclohexyl-3-(2-hydroxy-3-methoxy-2-methylpropyl)urea","PE(PGJ2/20:0)","4,4alpha,5,6-Tetrahydro-7-methyl-2(3H)-naphthalenone","Gamma-Glutamylmethionine","Lithocholyltaurine","L-Hypoglycin A","2-aminooctadec-4-ene-1,3-diol","S-Methylthiocitrulline","6-Lactoyltetrahydropterin","Betaine","[6]-Gingerdiol 5-O-beta-D-glucopyranoside","(13E)-11a-Hydroxy-9,15-dioxoprost-13-enoic acid","D-TYROSINE","3-Butylidene-1(3H)-isobenzofuranone","Lotaustralin","PE(15:0/20:4(8Z,11Z,14Z,17Z))","P-Hydroxyfelbamate","1-Heptanol","Floionolic acid","Oxalosuccinate","N-(6-Cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl)-N-methylethanesulfonamide","Dehydrovomifoliol","LysoPC(17:0/0:0)","Prostaglandin F-1-alpha","PC(20:4(8Z,11Z,14Z,17Z)/16:0)","LysoPE(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)","N-[(3s)-2-Oxotetrahydrofuran-3-Yl]butanamide","13(S)-Hydroperoxylinolenic acid","Cucurbic acid","Cystine-glutamate","Isoquinoline","17-hydroxyprogesterone caproate","Leu-Leu-Tyr","Nesbuvir","L-Lysine","LysoPE(18:0/0:0)","Val Val","2-Aminoadipic acid","5-Methoxyindoleacetate","1-Methylhistidine","Allysine","3-Hydroxynorvaline","Sphinganine","Xi-4-Hydroxy-4-methyl-2-cyclohexen-1-one","(3E,5Z)-3,5-Octadien-1-ol","P-coumaroyltriacetic acid lactone","2-Butenedioic acid (2Z)-, dioctyl ester","Glycyl-Lysine","Butyryl-L-carnitine","KAPA","3-Ketosphingosine","13,16,19-Docosatrienoic acid","O-Adipoylcarnitine","PC(18:2(9Z,12Z)/18:0)","DL-p-Chlorophenylalanine methyl ester hydrochloride","Valyltryptophan","2-Amino-4-[carbamimidoyl(methyl)amino]butanoic acid","Asi-222","(2'E,4'Z,7'Z,8E)-Colnelenic acid","Spirilloxanthin","Oxybutynin","22-Hydroxydocosanoic acid","2-{2-[3-(2-Carbamimidoylsulfanyl-ethyl)-phenyl]-ethyl}-isothiourea","Ethyl 3-hydroxydodecanoate","Ethisterone","Seryllysine","Gamma-Glutamyl-beta-aminopropiononitrile","4-Amino-1-piperidinecarboxylic acid","D-Fructose","Gamma-Glu-Leu","Embelin","Isoleucylproline","Flumethasone","Cis,cis-Muconic acid","Geldanamycin","Naltrexone","2-(4-Chlorophenoxy)propionic acid","Metallibure","4-Hydroxy-L-Proline","1-Hexadecanoyl-sn-Glycero-3-Phosphoethanolamine","Bisbenzimide","5-Fluoromethylornithine","Enalapril","L-Threonine","5-Hydroxyvalproic acid","7-Aminoheptanoic acid","Oryzalexin E","8-Amino-7-oxononanoic acid","Nomega-Acetylhistamine","N-Acetylcarnosine","2,8-Quinolinediol","2,4-dimethylhexanedioylcarnitine","(17alpha,23S)-17,23-Epoxy-29-hydroxy-27-norlanosta-1,8-diene-3,15,24-trione","Aminomethyl fluorescein","Garcinia acid","Trifolirhizin","Stearaldehyde","Porphobilinogen","Danazol","Phytuberin","LysoPC(22:4(7Z,10Z,13Z,16Z)/0:0)","LysoPC(20:4(8Z,11Z,14Z,17Z)/0:0)","3-Gonal","5-Methoxy-3,4-methylenedioxyamphetamine","(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate","CD 1790","4-Hydroxyvalproic acid","1-Methylguanosine","Tuliposide B","Alcophosphamide","Pelargonidin 3-sophoroside","XI-Dihydro-2-methyl-3(2H)-thiophenone","Trans-Cinnamic acid","2-Hydroxycampholonic acid","Anthracene-9-carboxylic acid","Butylisopropylamine","Methyltrienolone","L-4-Chlorotryptophan","Cinncassiol A","Cyclopentenyl cytosine","TIAZOFURIN","Peonidin 3-rutinoside","Lauryldiethanolamine","(5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate","Vigabatrin","Maleic acid homopolymer","Arginine ornithine","Azacyclotridecan-2-one","Ammelide","L-Tryptophan","Triethanolamine","LysoPE(0:0/22:5(7Z,10Z,13Z,16Z,19Z))","Tetracaine","Niacinamide","MJDBISSP00000002","2-Lysophosphatidylcholine","Diaminopimelic acid","Aspirin","Dopamine","Gamma-Dodecalactone","Serotonin","Dihydrozeatin","Parsalmide","Kojic acid","MJDBISSP00000001","3-oxocholest-4-en-26-oate","(+/-)-1,4-Nonanediol diacetate","PC(20:0/18:4(6Z,9Z,12Z,15Z))","Phaseic acid","2-(2-Ethyl-3H-1-benzofuran-2-yl)-1H-imidazole","MJDBISSP00000009","Zeranol","1-hexadecyl-glycero-3-phosphate","Pretyrosine","L-alpha-Amino-1H-pyrrole-1-hexanoic acid","Pentaethylene glycol","(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid","Aspartyl-Lysine","L-Aspartate-semialdehyde","Racemethionine","Trolamine","L-Valine","5-((6-((Aminomethyl)amino)-1-oxohexyl)amino)pentanoic acid","Uracil","6-(Cyclopentylideneamino)-1H-pyrimidin-2-one","Cinnamaldehyde","Pseudoecgonine","LysoPC(18:3(6Z,9Z,12Z)/0:0)","Cuminaldehyde","Methionyl-Valine","N-Acetylserotonin","Azithromycin","Oxalosuccinic acid","Glutaminyllysine","Azacitidine","Isoleucylhydroxyproline","Behenic acid","PC(20:4(8Z,11Z,14Z,17Z)/18:1(11Z))","Indoleacrylic acid","(2-Ethylcrotonoyl)urea","Artabsin","(2S)-3-Hydroxy-1-[(2S)-pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid","(+/-)-erythro-Isoleucine","9,10-Dihydroxystearic acid","Homoarginine","7,8-Dihydro-3b,6a-dihydroxy-alpha-ionol 9-glucoside","Lenticin","Pectin","MG(0:0/20:3(6,8,11)-OH(5)/0:0)","Guanidine, (4-chloro-3-methoxy-1-oxo-1H-2-benzopyran-7-yl)-","N(5)-Acetylornithine","7,8-diaminopelargonate","LysoPC(18:2(9Z,12Z)/0:0)","Hypoxanthine","(3S,5R,6R,7E)-3,5,6-Trihydroxy-7-megastigmen-9-one","Psilocybine","Octa-3,5-dienedioylcarnitine","Fluocinolone acetonide 21-acetate","Amotosalen","Hippuric acid","PC(16:0/18:3(9Z,12Z,15Z))","N-Caffeoyltryptophan","Statine","Pristimerin","Rishitin","2-Methylbenzaldehyde","3-Hydroxyphenylacetic Acid","Taurochenodesoxycholic acid","Beta-Zearalenol","Normethandrone","Choline Phosphate","3-Fumarylpyruvate","Clofibric acid","3-Deoxyglucosone","1-(4-chlorophenyl)-4-(5-phenyl-1,2,4-oxadiazol-3-yl)pyrrolidin-2-one","PC(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","PE(16:1(9Z)/P-18:0)","Diallyl Trisulfide","N6,N6,N6-Trimethyl-L-lysine","Salviol","Vomifoliol","1-Phenylethanol","Methyl 3-Phenyl-2-(phenylformamido)propanoate","Harmaline","6-Acetyl-1,2,3,4-tetrahydropyridine","Gamma-Glutamylleucine","Cis-4-Decenedioic acid","Adenine","6-Acetamidohexanoic acid","5-Hydroxy-L-Tryptophan","Coixinden B","1-(11Z-docosenoyl)-glycero-3-phosphate","7-Aminomethyl-7-carbaguanine","N2-Acetyl-L-ornithine","LysoPC(16:0/0:0)","Metazin","(3Z)-2-Propylpent-3-enoic acid","L-Serine","PC(18:1(11Z)/18:3(9Z,12Z,15Z))","P-Hydroxynefazodone","Aminocaproic Acid","N-Acetyl-L-phenylalanine","ISOSAFROLE","Val-Cit","Canin","2-Pentyl-3-phenyl-2-propenal","2-Maleylacetate","4,5-Dihydrovomifoliol","(+/-)-2-Butylthiazolidine","(+/-)-6-Chlorotryptophan","16-Hydroxyhexadecanoic acid","PC(2:0/20:5(5Z,8Z,11Z,14Z,16E)-OH(18R))","5-Aminovaleric Acid","Anserine","(+)-Nicotine","Saccharopine","P-Tolualdehyde","N-alpha-Acetyl-L-lysine","Cefadroxil","Indolophenanthridine","FAHFA(16:0/9-O-18:0)","N-[(1R,2S)-2-(dimethylcarbamoyl)cyclopentyl]-6-methoxypyridine-3-carboxamide","(S)-5-Amino-3-oxohexanoate","2-Methyl-1-propylamine","Pyroglutamic Acid","6-Aminopenicillanic acid","12-Hydroxydodecanoic acid","Valproic acid","Arbutin","5-Methyl-1H-Benzotriazole","Sebacic acid","Prazosin","L-Methionine","Decylamine Oxide","2,3,4-Trihydroxybutanoic acid","(+/-)-2-Hydroxy-4-(methylthio)butanoic acid","Linustatin","Valylhydroxyproline","Aceteugenol","DG(PGD2/0:0/i-18:0)","2-cis-abscisate","Isobutyl 4-hydroxybenzoate","N-Hydroxy-L-tyrosine","5'-Phosphoribosyl-N-formylglycinamide","2,2,6,6-Tetramethyl-4-piperidinone","Sumiki's acid","Peanut oil, hydrogenated","2-Aminobenzimidazole","Isohexylcyanoacrylate","Hydroxyphenylacetylglycine","16-feruloyloxypalmitate","PC(20:1(11Z)/18:4(6Z,9Z,12Z,15Z))","Hymenoxon","Chavicol","Fentiazac","6-Hydroxypentadecanedioic acid","8'-hydroxyabscisate","Dehydronorketamine","PE(P-16:0/16:0)","(3Z)-phytochromobilin","S-Hydroxymethylglutathione","Ethiin","N-Acetylputrescine","Purpurogallin","O-Acetylcarnitine","3,4,5-Trihydroxypentanoylcarnitine","Senkyunolide","3h-Indole-3-propanoic acid,a-amino-","PC(18:1(11Z)/20:4(8Z,11Z,14Z,17Z))","L-Glutamine","4-Heptyloxyphenol","PC(20:4(8Z,11Z,14Z,17Z)/20:3(5Z,8Z,11Z))","Cyclo-dopa 5-O-glucoside","4-(2-chloroanilino)-4-oxobutanoic acid","1-Stearoylglycerophosphoserine","Indolelactic Acid","(+/-)-Pelletierine","19-Epischolaricine","5-Hydroxy-2-imino-1-methylimidazolidin-4-one","Gamma-Glutamylacetamide","1-Hydroxy-2,2,5,5-tetramethylpyrrolidine-3-carboxamide","(9Z)-12-oxo-dodec-9-enoate","3-(Cyclohexylamino)-2-hydroxy-1-propanesulfonic acid","Thymidine","Tranexamic Acid","Calcifediol lactone","4-(2-Aminophenyl)-2,4-dioxobutanoic acid","L-Isoleucine","RHODAMINE 6G","4-Amino-3-hydroxybutyrate","LysoPE(18:2(9Z,12Z)/0:0)","4-Morpholinepropanamine","3-Hydroxy-4-aminopyridine sulfate","Glycylprolylarginine","Sn-glycero-3-Phosphoethanolamine","(2R,3R)-2-Aminooctadecane-1,3-diol","Theasaponin F1","2-Aminopurine","Indole-3-acetaldehyde","Phosalone","PC(20:2(11Z,14Z)/20:3(8Z,11Z,14Z))","L-2-Amino-5-hydroxypentanoic acid","Palmitoylcarnitine","Etiracetam","(2R,3R,4R)-2-Amino-4-hydroxy-3-methylpentanoic acid","Adipate semialdehyde","Histamine","PC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/P-16:0)","N-Acetyltyrosine","LysoPC(20:4(5Z,8Z,11Z,14Z)/0:0)","Eplerenone","2-Mercaptobenzothiazole","Beta-Thujaplicin","Oxypurinol","N-Alpha-acetyllysine","LysoPC(22:5(4Z,7Z,10Z,13Z,16Z)/0:0)","1-[1-(2-Methoxyethyl)piperidin-3-YL]-N-methylmethanamine","4-Mercapto-ethyl-pyridine","Methionine sulfoxide","2,5-Dimethyl-4-ethoxy-3(2H)-furanone","4-Chlorobenzaldehyde","6-methyl-5-Hepten-2-one","Jasmolone","Oxadixyl","Taurodeoxycholic acid","17beta-Estradiol-2,3-quinone","4-Hydroxy-3-(3-methyl-2-butenyl)acetophenone","Estrone-3,4-quinone","4-Formyl-3-(formylmethyl)-4-hexenoic acid","Azelaic acid","(11R,16S)-misoprostol","LysoPC(P-18:0/0:0)","3,7-Dihydroxydecanoylcarnitine","LysoPC(22:5(7Z,10Z,13Z,16Z,19Z)/0:0)","Yucalexin B'11","Ethoxyquin","Thiogeraniol","4-Chloro-L-phenylalanine","N1-trans-Feruloylagmatine","Glycerylphosphorylcholine","2-Aminobenzoic Acid","4a-Hydroxytetrahydrobiopterin","3-dehydrocholate","Isoleucyl-thiazolidine","Cyclohexanecarboxylic acid","1-Octene","S-Lactoylglutathione","Methacycline","Valylproline","Acetolein","Lubiprostone","Estrone","Ceftibuten","(R)-Oxypeucedanin","Prostaglandin F1a","2-[2-[(1R,2R)-1-(5-Tert-butyl-2-methoxyphenyl)-2-(dimethylamino)-1-hydroxypropyl]phenoxy]acetamide","5,7-Megastigmadien-9-ol glucoside","Manool","28-Homobrassinolide"],"additional_accession":[]},"is_claimable":false,"name":"Plasma non-targeted metabolome of high- and low-body-weight broilers","description":"In large-scale poultry farming, broilers of the same breed share a common genetic background and identical management conditions, yet substantial individual variation in body weight persists. In this study, we identified distinct plasma proteomic profiles between high and low weight broilers, with low weight broilers exhibiting a heightened systemic inflammatory response. The gut microbiome differences between groups were minimal, and fecal microbiota transplantation from high or low weight broilers did not significantly affect body weight. However, lung microbiome analysis revealed that high weight broilers had a significantly higher abundance of Lactobacillus, associated with altered plasma tryptophan metabolism. Aerosolized Lactobacillus rhamnosus, Lactobacillus reuteri, and their combination were administered to modulate the lung microbiota. This intervention significantly enhanced production performance and alleviated LPS-induced systemic inflammation. Aerosolization of Lactobacillus strains elevated metabolites such as L-tryptophan (Trp), indoleacrylic acid (IAA), and indole-3-carboxaldehyde (I3C) in plasma and lung tissues. Mechanistic explorations elucidate that IAA and I3C activated the aryl hydrocarbon receptor (AHR) pathway, promoting nuclear translocation and upregulating SOCS3 expression in macrophages. This inhibited the JAK2/STAT3 signaling pathway, mitigating LPS-induced inflammation. Our findings provide insights into the interaction between poultry production and lung microbiota, establishing Lactobacillus aerosolization as a promising strategy to combat systemic inflammation and improve poultry health and performance.
","dates":{"publication":"2025-06-10","submission":"2025-04-16"},"accession":"MTBLS12390","cross_references":{"HMDB":["HMDB0029030","HMDB0257780","HMDB0028881","HMDB0303035","HMDB0253955","HMDB0251890","HMDB0246466","HMDB0059994","HMDB0000866;HMDB0244966;MJDBOTE0000672","HMDB0011170","HMDB0029042","HMDB0260397","HMDB0254284","HMDB0304170","HMDB0012149","HMDB0006833;LMFA01050472","HMDB0010717;PW_C006725","HMDB0000508","HMDB0246022","HMDB0001474","HMDB0014917","HMDB0245031","HMDB0255052","HMDB0029384","HMDB0001013;PW_C000801","HMDB0257269","HMDB0013696","HMDB0246151;HMDB0242167;HMDB0000600","HMDB0256033","HMDB0248298","HMDB0258506","HMDB0249718","HMDB0244158","HMDB0029722","HMDB0035140","HMDB0006779;PW_C002926","HMDB0248564","HMDB0033999","HMDB0001199","HMDB0243852","HMDB0302272","HMDB0255169;HMDB0244929","HMDB0006061","HMDB0244975","HMDB0013716;MJDBOTE0000679","HMDB0036684","HMDB0000872;LMFA01170018","HMDB0035287","HMDB0250582;LMST01010110","HMDB0301805","HMDB0032370","HMDB0244261","HMDB0011514","HMDB0240259","HMDB0240603","HMDB0253625;HMDB0038510","HMDB0113951;PW_C059967","HMDB0256087","HMDB0007856","HMDB0240597","HMDB0031078;LMFA06000083","HMDB0031066","HMDB0304342;LMFA01170037;HMDB0242127","HMDB0030700","HMDB0029171","HMDB0247706;PW_C000530;LMFA01030120;HMDB0006270;HMDB0000673;MJDBOTE0000548","HMDB0010381;HMDB0010375","HMDB0062549;HMDB0242145","HMDB0240598","HMDB0257360","HMDB0013464","HMDB0032401","HMDB0249432;LMST01130023","HMDB0250305","HMDB0296914","HMDB0004866;LMSP0501AB02","HMDB0011680","HMDB0113104;PW_C059227","HMDB0012880","HMDB0250782","HMDB0246765","HMDB0242418","HMDB0002815","HMDB0011128","HMDB0251202","HMDB0287067","HMDB0245586","HMDB0248619","HMDB0257261","HMDB0261915","HMDB0244819","HMDB0030666","HMDB0255731","HMDB0007853","HMDB0260189","HMDB0242387","HMDB0031031;HMDB0059915","HMDB0036640","HMDB0245560;HMDB0012641;HMDB0006059","HMDB0035922","HMDB0002183;PW_C001472;LMFA01031176;MJDBOTE0001119","HMDB0240606","HMDB0014554;MJDBOTE0001685","HMDB0256030","HMDB0256157;LMGP01050127","HMDB0061699","HMDB0245565","HMDB0038029","HMDB0244523","HMDB0011513","HMDB0061691","HMDB0260018","HMDB0012986","HMDB0004708;LMFA02000014","HMDB0010397","HMDB0003871","HMDB0038527","HMDB0015070","HMDB0059633","HMDB0012176","HMDB0062281","HMDB0246655","HMDB0029160;HMDB0252908","HMDB0032667","HMDB0006940","HMDB0032090","HMDB0041939","HMDB0253102","HMDB0015166","HMDB0000889;LMST05040014","HMDB0004710","HMDB0242396","HMDB0094660","HMDB0302340","HMDB0034462","HMDB0005767","HMDB0014698","HMDB0249258","HMDB0253188","HMDB0255912","HMDB0247524","HMDB0246968","HMDB0256428;HMDB0000159","HMDB0240389;HMDB0303992","HMDB0248921","HMDB0260376","HMDB0004041","HMDB0000750","HMDB0028745","HMDB0304012","HMDB0014932","HMDB0001366","HMDB0259481","HMDB0014755","HMDB0015350","HMDB0041731","HMDB0256800","HMDB0244490","HMDB0015544","HMDB0247440","HMDB0253770","HMDB0012233","HMDB0245768","HMDB0253424","HMDB0252080","HMDB0010363","HMDB0028993","HMDB0247322","HMDB0000682","HMDB0259508","HMDB0041646","HMDB0001007","HMDB0000857;LMFA01170051","HMDB0004086;PW_C002055","HMDB0258513;HMDB0014572;HMDB0258518","HMDB0002062","HMDB0250956","HMDB0252827","HMDB0257458","HMDB0245511","HMDB0304906","HMDB0244232","HMDB0041709","HMDB0060002","HMDB0000528;HMDB0003349","HMDB0258910","HMDB0246099","HMDB0041031","HMDB0304910","HMDB0029833;HMDB0304310","HMDB0253008","HMDB0255152","HMDB0252619","HMDB0001921","HMDB0028832","HMDB0304928","HMDB0252905","HMDB0246877","HMDB0028930","HMDB0246885","HMDB0301964","HMDB0015109;HMDB0303556","HMDB0012152","HMDB0036251","HMDB0000296;PW_C000202;MJDBOTE0000788","HMDB0250357","HMDB0002327","HMDB0029757","HMDB0256781;HMDB0006695","HMDB0258086","HMDB0029426","HMDB0247862","HMDB0258453","HMDB0257364;LMST01080038","HMDB0010404","HMDB0042032","HMDB0029612","HMDB0060459","HMDB0254402","HMDB0302373","HMDB0257201","HMDB0060626","HMDB0035722","HMDB0113373;PW_C059497","HMDB0240262","HMDB0028831","HMDB0029717","HMDB0243816","HMDB0028822","HMDB0000594","HMDB0257824","HMDB0249114","HMDB0060726","HMDB0000195;PW_C000127;HMDB0247301;MJDBOTE0000386","HMDB0030794","HMDB0258059","HMDB0015037;PW_C009350","HMDB0038614","HMDB0002248","HMDB0248563","HMDB0033939","HMDB0255105;HMDB0031314","HMDB0250642","HMDB0302700","HMDB0000623;HMDB0000933;LMFA01170009;MJDBOTE0000650","HMDB0000638;LMFA01010012;PW_C000497;HMDB0303348;HMDB0303347;HMDB0002262","HMDB0000712;LMFA01170022;HMDB0000672;HMDB0304377","HMDB0000148;HMDB0000138;HMDB0255104","HMDB0037479;HMDB0030610;LMPK12120294;MJDBOTE0001182","HMDB0000951;PW_C000759","HMDB0248824","HMDB0015168;LMFA08010013","HMDB0033865","HMDB0036611","HMDB0006900","HMDB0003357","HMDB0060405","HMDB0304363;LMPR0104170011","HMDB0029044","HMDB0000851","HMDB0250668","HMDB0000786","HMDB0011648;HMDB0011643","HMDB0241652","HMDB0028906","HMDB0244522;LMFA01030407;HMDB0002823","HMDB0293086","HMDB0029134;HMDB0255244","HMDB0011507","HMDB0303673","HMDB0244397","HMDB0304246","HMDB0253927","HMDB0242468","HMDB0002835","HMDB0247031","HMDB0028846","HMDB025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