MetaboLights

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metabolites were annotated using the KEGG database, HMDB database and LIPIDMaps database. Principal components analysis (PCA) and Partial least squares discriminant analysis (PLS-DA) were performed at metaX (a flexible and comprehensive software for processing metabolomics data). We applied univariate analysis (t-test) to calculate the statistical significance (P-value). The metabolites with VIP > 1 and P-value < 0.05 and fold change ≥ 2 or FC ≤ 0.5 were considered to be differential metabolites.MetaboLightsPublicLiquid Chromatography MS - negative - reverse phaseLiquid Chromatography MS - positive - reverse phaseUHPLC-MS/MS analyses were performed using a Vanquish UHPLC system (ThermoFisher, Germany) coupled with an Orbitrap Q Exactive HF mass spectrometer or Orbitrap Q Exactive HF-X mass spectrometer (Thermo Fisher, Germany) in Novogene Co., Ltd (Beijing, China). Samples were injected onto a Hypersil Goldcolumn (100 x 2.1 mm, 1.9 μm) using a 12-min linear gradient at a flow rate of 0.2 mL/min. The eluents for the positive and negative polarity modes were eluent A (0.1% FA in Water) and eluent B (Methanol). The solvent gradient was set as follows: 2% B, 1.5 min; 2-85% B, 3.0 min; 85-100% B, 10.0 min; 100-2% B, 10.1 min; 2% B, 12.0 min. Q Exactive HF mass spectrometer was operated in positive/negative polarity mode with spray voltage of 3.5 kV, capillary temperature of 320 °C, sheath gas flow rate of 35 psi and aux gas flow rate of 10 L/min, S-lens RF level of 60, Aux gas heater temperature of 350 °C.Berberine alleviates radiation-induced lung injury through promoting microbiota-derived inosine via gut-lung axis.Ding boshengZhejiang Guangsha Vocational and Technical University of Constructionlungfecesmass spectrometry assayTissues (100 mg) were individually grounded with liquid nitrogen and the homogenate was resuspended with prechilled 80% methanol by well vortex. The samples were incubated on ice for 5 min and then were centrifuged at 15,000 x g, 4 °C for 20 min. Some of supernatant was diluted to final concentration containing 53% methanol by LC-MS grade water.The samples were subsequently transferred to a fresh Eppendorf tube and thenwere centrifuged at 15,000 x g, 4 °C for 20 min. Finally, the supernatant was injected into the LC-MS/MS system analysis.Mus musculushttps://www.ebi.ac.uk/metabolights/MTBLS12391Shuyuan Wang. Nankai University. ShuyuanWang1030@163.com.Jianxiong Li. PLA General Hospital. 301301ljx@sina.com.The raw data files generated by UHPLC-MS/MS were processed using the Compound Discoverer 3.3 (CD3.3, ThermoFisher) to perform peak alignment, peak picking and quantitation for each metabolite. The main parameters were set as follows: peak area was corrected with the first QC, actual mass tolerance, 5 ppm; signal intensity tolerance, 30%; and minimum intensity, et al. After that, peak intensities were normalized to the total spectral intensity.The normalized data was used to predict the molecular formula based on additive ions, molecular ion peaks and fragment ions.Part15700153239@163.comFreshly collected fecal samples were promptly subjected to snap-freezing in liquid nitrogen and maintained at -80 °C until further processing. In the case of lung tissues, following euthanasia of the mice, the lungs were carefully excised and thoroughly washed with cold PBS to remove any residual blood. Subsequently, the lung tissues were snap-frozen in liquid nitrogen and stored at -80 °C until further processing.MetabolomicsBerberineLung Radiation InjuryEpigeneticsuntargeted metabolitesBerberineLung Radiation InjuryEpigeneticsuntargeted metabolitesUHPLC-MS/MS analyses were performed using a Vanquish UHPLC system (ThermoFisher, Germany) coupled with an Orbitrap Q Exactive HF mass spectrometer or Orbitrap Q Exactive HF-X mass spectrometer (Thermo Fisher, Germany) in Novogene Co., Ltd (Beijing, China). Samples were injected onto a Hypersil Goldcolumn (100 x 2.1 mm, 1.9 μm) using a 12-min linear gradient at a flow rate of 0.2 mL/min. The eluents for the positive and negative polarity modes were eluent A (0.1% FA in Water) and eluent B (Methanol). The solvent gradient was set as follows: 2% B, 1.5 min; 2-85% B, 3.0 min; 85-100% B, 10.0 min; 100-2% B, 10.1 min; 2% B, 12.0 min. Q Exactive HF mass spectrometer was operated in positive/negative polarity mode with spray voltage of 3.5 kV, capillary temperature of 320 °C, sheath gas flow rate of 35 psi and aux gas flow rate of 10 L/min, S-lens RF level of 60, Aux gas heater temperature of 350 °C.falseBerberine alleviates radiation-induced lung injury through promoting microbiota-derived inosine via gut-lung axisRadiation-induced lung injury (RILI) is a major complication of thoracic radiotherapy. A previous study has indicated an association between berberine (BBR) and reduced incidence of RILI. However, the underlying mechanisms remain unknown. Here we validated the radioprotective role of BBR in mouse model, and we found that this effect was due to gut microbiota modulation as evidenced by microbiota depletion and fecal microbiota transplantation. Specifically, BBR treatment enriched the abundance of Akkermansia muciniphila in gut and its metabolite, inosine (INO). INO exerted protective effects against RILI via epigenetic regulation of NAV3 through H3K27me3 modification. Our findings suggest the potential of BBR in developing therapeutic strategies for RILI and provides insights into its radioprotection mechanism. Additionally, INO could serve as a complementary approach to enhance radioprotection in RILI.2025-05-142025-04-11MTBLS12391