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The R package and the BiotreeDB(V3.0) were applied in metabolite identification.</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse phaseLiquid Chromatography MS - positive - reverse phase<p>For polar metabolites, this project employs a Vanquish UHPLC system (Thermo Fisher Scientific) coupled with a Waters ACQUITY UPLC BEH Amide column (2.1 mm × 50 mm, 1.7 μm) for chromatographic separation of target compounds. The mobile phase consists of:</p><p>Phase A (aqueous phase): 25 mmol/L ammonium acetate and 25 mmol/L ammonia in water.</p><p>Phase B (organic phase): Acetonitrile.</p><p>The sample tray temperature was maintained at 4 °C, and the injection volume was 2 μL.</p>Characterization of the nasal microbiome and metabolome in children with Henoch-Schonlein purpura and children with Henoch-Schonlein purpura nephritis.Shuya ZhangThe First Affiliated Hospital of Henan University of Chinese MedicineNasal floramass spectrometry assay<p>(1) Transfer 1.5 ml of the sample into an EP tube and freeze-dry it. Add 500 μL of extraction solution (methanol:acetonitrile:water = 2:2:1 (V/V)), which contains isotopically labeled internal standards.</p><p>(2) Vortex mix for 30 s, then sonicate for 10 min (in an ice-water bath).</p><p>(3) Let it stand at -40 °C for 1 h.</p><p>(4) Centrifuge the sample at 4 °C, 12000 rpm (centrifugal force 13800 ×g, radius 8.6 cm) for 15 min.</p><p>(5) Transfer the supernatant into vials for instrumental analysis.</p><p>(6) For all samples, take an equal amount of supernatant and mix them to prepare QC samples for instrumental analysis.</p>Homo sapienshttps://www.ebi.ac.uk/metabolights/MTBLS12590Qingyin Guo. The First Affiliated Hospital of Henan University of Chinese Medicine. docgqy@163.com.Shuya Zhang. The First Affiliated Hospital of Henan University of Chinese Medicine. doczsy@163.com.<p>The raw data were converted to the mzXML format using ProteoWizard and processed with an in-house program. which was developed using R and based on XCMS, for peak detection, extraction, alignment, and integration.</p>Diseasedoczsy@163.com<p>The subject should sit comfortably with eyes open and the head tilted slightly forward. Using a FeiYang LeKang Nasal Irrigation Device pre-filled with sterile saline, irrigate both nasal cavities for 30 seconds per side. Collect 7.5 mL from each nostril (total 15 mL).</p><p>The lavage fluid is then drained into a sterile Petri dish. The contents of the dish are passed through a 100 µm cell strainer and transferred to a centrifuge tube. The sample is then centrifuged at 3000 × g at 4°C. The supernatant is aliquoted into cryovials and stored in a −80°C freezer.</p>MetabolomicsNasalHSPuntargeted analysischildrenThe Orbitrap Exploris 120 mass spectrometerHSPNXHomo sapiensuntargeted metabolitesVanquish UHPLC system (Thermo Fisher Scientific)Nasal floraNasalHSPuntargeted analysischildrenThe Orbitrap Exploris 120 mass spectrometerHSPNXHomo sapiensuntargeted metabolitesVanquish UHPLC system (Thermo Fisher Scientific)Nasal flora<p>The Orbitrap Exploris 120 mass spectrometer is capable of acquiring both full-scan MS and MS/MS data under the control of the Xcalibur software (version: 4.4, Thermo). The detailed parameters are as follows:</p><p>Sheath gas flow rate: 50 Arb</p><p>Aux gas flow rate: 15 Arb</p><p>Capillary temperature: 320 °C</p><p>Full MS resolution: 60,000</p><p>MS/MS resolution: 15,000</p><p>Collision energy: SNCE 20/30/40</p><p>Spray voltage: 3.8 kV (positive mode) or -3.4 kV (negative mode)</p>ThyminefalseCharacterization of the nasal microbiome and metabolome in children with Henoch-Schonlein purpura and children with Henoch-Schonlein purpura nephritis<p>Three groups of eligible subjects were included, including 20 cases in the HSP group, 20 cases in the HSPN group, and 20 cases in the healthy control (HC) group. Nasal lavage samples from each group were subjected to 16SrRNA gene sequencing and metabolomic analyses to screen differential flora and differential metabolites, and Spearman correlation analysis was done.</p>2026-04-112025-06-11MTBLS12590