Database searches were performed using both proprietary in-house databases from Personal Biotechnology Co., Ltd, and public databases (Fiehn HILIC, ReSpect, GNPS, MetaboBASE, OTCML, Fiehn/Vaniya, natural product, HMDB, Mass Bank). For peak picking, the following parameters were used: MS1 m/z Tolerance: +-5 ppm, MS2 similarity score: > 0.7. CAMERA (Collection of Algorithms of MEtabolite pRofile Annotation) was used for annotation of isotopes and adducts. In the extracted ion features, only the variables having more than 50% of the nonzero measurement values in at least one group were kept. Compound identification of metabolites was performed by comparing of minimum ± 5 ppm, and MS/MS spectra with an in-house database established with available authentic standards.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - positive - HILIC","Liquid Chromatography MS - negative - HILIC"],"chromatography_protocol":["The samples were separated using an Agilent 1290 Infinity LC ultra-high-performance liquid chromatography system (UHPLC) with a HILIC column. The column temperature was maintained at 25 °C, with a flow rate of 0.5 mL/min and an injection volume of 2 μL. The mobile phase consisted of: (A) water + 25 mM ammonium acetate + 25 mM ammonia, and (B) acetonitrile. The gradient elution program was as follows: 0.0-0.5 min, 95% B; 0.5-7.0 min, B linearly decreased from 95% to 65%; 7.0-8.0 min, B linearly decreased from 65% to 40%; 8.0-9.0 min, B was held at 40%; 9.0-9.1 min, B linearly increased from 40% to 95%; and 9.1-12.0 min, B was maintained at 95%. Throughout the analysis, the samples were kept in the autosampler at 4 °C. To minimize the impact of instrumental signal fluctuations, the samples were analyzed continuously in a randomized order. Quality control (QC) samples were interspersed within the sample queue to monitor and evaluate system stability and the reliability of the experimental data.
"],"publication":["Metabolo-transcriptomics analyses reveal alfalfa adaptation to combined saline-alkali and low-temperature stress in the field."],"submitter_name":["Rui Guo"],"submitter_affiliation":["Harbin Normal University"],"organism_part":["root"],"technology_type":["mass spectrometry"],"disease":[""],"extraction_protocol":["Root sample (0.2 g) were added to a pre-chilled methanol/acetonitrile/water solution (2:2:1, v/v) and subjected to low-temperature ultrasonication for 30 min, followed by centrifugation at 14,000 x g and 4 °C for 20 min. The supernatant was collected and dried under vacuum.
"],"organism":["alfalfa"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS12611"],"author":["Guo Rui. guorui4u@stu.hrbnu.edu.cn.","Guo Changhong. kaku3008@hrbnu.edu.cn."],"data_transformation_protocol":["The raw MS data were converted to mzXML files using ProteoWizard MSConvert before importing into MS-DIAL software.
"],"study_factor":["Time"],"submitter_email":["guorui4u@126.com"],"sample_collection_protocol":["Two alfalfa varieties were studied: Zhaodong alfalfa (Medicago sativa cv. Zhaodong [ZD]), a fall-dormant type with saline-alkali tolerance (fall dormancy level (FDL) 1), and Blue Moon alfalfa (Medicago sativa cv. Blue Moon [BM]), a saline-alkali sensitive non-fall-dormant type FDL 8. The experiments were conducted at the Grassland Research Base of Heilongjiang Academy of Agricultural Sciences in Shengli Village, Yuanda Township, Lanxi County, Heilongjiang Province (geographic coordinates: 46°12′N, 126°08′E, Seeds were sown in strips: after soil plowing and leveling, 8 g of seeds were evenly distributed into 5 m-long furrows (2-3 cm deep). When the seedlings reached a height of 5-10 cm, they were thinned to 10 cm plant spacing and 30 cm row spacing. Routine field management, including regular weeding, was implemented to ensure normal growth, with a single mowing in August. Root samples for metabolomic sequencing were collected on September 12, 2022 (soil temperature: 20 °C, control group), October 25, 2022 (soil temperature: 5 °C, combined saline-alkali and cold acclimation stress group), and December 11, 2022 (soil temperature: -8 °C, combined saline-alkali and freezing stress group).
"],"omics_type":["Metabolomics"],"study_design":["untargeted metabolites","Alfalfa","Low temperature"],"curator_keywords":["untargeted metabolites","Alfalfa","Low temperature"],"mass_spectrometry_protocol":["Analysis was performed using an UHPLC (1290 Infinity LC, Agilent Technologies) coupled to a quadrupole time-of-flight (AB Sciex TripleTOF 6600).
For HILIC separation, samples were analyzed using a 2.1 mm x 100 mm ACQUIY UPLC BEH Amide 1.7 µm column (waters, Ireland). In both ESI positive and negative modes, the mobile phase contained A = 25 mM ammonium acetate and 25 mM ammonium hydroxide in water and B = acetonitrile. The gradient was 95% B for 0.5 min and was linearly reduced to 65% in 6.5 min, and then was reduced to 40% in 1 min and kept for 1 min, and then increased to 95% in 0.1 min, with a 3 min re-equilibration period employed. The ESI source conditions were set as follows: Ion Source Gas1 (Gas1) as 60, Ion Source Gas2
(Gas2) as 60, curtain gas (CUR) as 30, source temperature as 600 °C, IonSpray Voltage Floating (ISVF) ± 5500 V. In MS only acquisition, the instrument was set to acquire over the m/z range 60-1000 Da, and the accumulation time for TOF MS scan was set at 0.20 s/spectra. In auto MS/MS acquisition, the instrument was set to acquire over the m/z range 25-1000 Da, and the accumulation time for product ion scan was set at 0.05 s/spectra. The product ion scan is acquired using information dependent acquisition (IDA) with high sensitivity mode selected. The parameters were set as follows: the collision energy (CE) was fixed at 35 V with ± 15 eV; declustering potential (DP), 60 V (+) and -60 V (-); exclude isotopes within 4 Da, candidate ions to monitor per cycle: 10.
"],"metabolite_name":["Ginkgolic acid (C13:0)","3-HYDROXY-4-(SUCCIN-2-YL)-CARYOLANE delta-LACTONE","Kaempferol 3-O-sophoroside","Ginsenoside-Rg1","Saikosaponin C","Microcystin-LR","Riboflavin","Mycophenolic acid IV","(3beta,5xi,9xi,18xi)-22-Hydroxyolean-12-en-3-yl O--6-deoxyhexopyranosyl-(1->2)-O-pentopyranosyl-(1->2)-hexopyranosiduronic acid","Oroxin A","N-beta-Alanyl-L-histidine","Piceatannol","3-(4-Fluorobenzoyl)propionic acid","Tectorigenin","Biochanin-7-O-glucoside","Methyl hexadecanoate","Ophiopogonin D","2-Decyl-3-hydroxypentanedioic acid","Coumestrol","Unguisin E","4-Oxonon-2-enoic Acid","Loureirin A","2'-Hydroxy-4'-methoxychalcone","FA 19:0","(2S,3S,4S,5R,6R)-6-[[(3S,6aR,6bS,8aS,14bR)-8a-carboxy-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3-hydroxy-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-5-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxane-2-carboxylic acid","Leucoside","FA 19:1","Indole + 1O, 1carboxy, O-Hex","Kukoamine A","Nevadensin","Tetracosanoic acid","Dehydroabietic acid","Saikosaponin a","Dinoprost","PG 30:0","Scopoletin","Kukoamine B","Licoricesaponin H2","Dihydrohesperetin-7-O-neohesperidoside","FA 18:2;O","Phenol","Hypericin","Momordin Ic","Narcissin","(2S,4R,9beta,16alpha,17xi,23E)-2-(beta-D-Glucopyranosyloxy)-16,20-dihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate","Cyclic guanosine monophosphate","3-Hydroxyanthranilic acid","9-Hydroperoxyoctadeca-10,12-dienoic acid","Cianidanol","FA 23:0;2O","4-Hydroxybenzaldehyde","6-[[(3S,6aR,6bS,8aR,14bS)-9-hydroxy-4,4,6a,6b,8a,11,11,14b-octamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,13,14a-dodecahydro-1H-picen-3-yl]oxy]-5-[4,5-dihydroxy-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxy-3,4-dihydroxyoxane-2-carboxylic acid","(2R,3R,4R,6Ar,6bS,8aS,11R,12R,12aS,14bR)-2,3,12-trihydroxy-4,6a,6b,11,12,14b-hexamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,11,12a,14,14a-tetradecahydropicene-4-carboxylic acid","6-Hydroxyflavone","9-HOTrE","Cinnamic acid","Calceolarioside B","12-Hydroperoxyoctadeca-9,13,15-trienoic acid","Licoricesaponin G2","Cauloside C","Soyasaponin Ba","Arginine","7,4'-Dihydroxyflavone","(2S,3S,4S,5R,6R)-6-[[(3S,6aR,6bS,8aS,14bR)-8a-carboxy-4-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid","Oleic acid","4'-[6-O-(4-Hydroxycinnamoyl)beta-D-glucopyranosyloxy]-2',3',4-trihydroxychalcone","Soyasaponin Bb","Isoanhydroicaritin","(3R,8R)-10-[(2R,5R)-3,5-Dihydroxy-6-methyloxan-2-yl]oxy-3,8-dihydroxyundecanoic acid","Hydroxygenkwanin","3,5-Dihydroxy-2-(4-hydroxyphenyl)-7-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3-dihydrochromen-4-one","FA 18:4","2',4'-Dihydroxychalcone","Tenuifolin","(2R,3R,4R,5R,6S)-2-[(4S,6R,7S,8R,9S,13R,14R,16R)-14-[(2R,3R,4S,5R,6R)-4,5-dihydroxy-6-methyl-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-7,9,13-trimethyl-5'-methylidenespiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxy-6-methyloxane-3,4,5-triol??","Glycitein","4',7-Dihydroxyflavanone","4,4'-Sulfonyldiphenol","(-)-Podophyllotoxin","7-Formyl-4,6'-dihydroxy-6-(hydroxymethyl)-2',5',5',8a'-tetramethyl-3',4',4a',5',6',7',8',8a'-octahydro-2'H,3H-spiro[1-benzofuran-2,1'-naphthalen]-7'-yl acetate","Poricoic acid A","[3-[2-Aminoethoxy(hydroxy)phosphoryl]oxy-2-hydroxypropyl] octadeca-9,12-dienoate","2-(3-(8-hydroxyoctyl)phenoxy)-2-methylpropanoic acid","Madecassic acid","Betulinic acid","Ligustroflavone","14-(3-Ethyloxiran-2-YL)tetradeca-9,12-dienoic acid","1-O-[(3beta,5xi,9xi,18xi)-3-(beta-D-Glucopyranuronosyloxy)-28-oxoolean-12-en-28-yl]-beta-D-glucopyranose","Pantothenic acid","4-Pyridoxic acid","Apigenin-7-O-neohesperidoside","(3R,7R,8R,8aS)-3,4'-Dihydroxy-7'-(2-hydroxyethyl)-4,4,7,8a-tetramethylspiro[2,3,4a,5,6,7-hexahydro-1H-naphthalene-8,2'-3,8-dihydrofuro[2,3-e]isoindole]-6'-one","Flavanone base + 3O, C-Hex","Medicagenic acid base + O-HexA, O-Pen-dHex-Pen","(2S,3S,4S,5R,6R)-6-[[(2S,3R,4S,6aR,6bS,8aS,14bR)-4-carboxy-8a-[(2R,3R,4S,5S)-3-[(2S,3R,4S,5R,6S)-3,4-dihydroxy-6-methyl-5-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]oxycarbonyl-2-hydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid","2-[(1S,2S,4aR,8aS)-1-Hydroxy-4a-methyl-8-methylenedecahydro-2-naphthalenyl]acrylic acid","Guanosine","8-(2-Oxo-5-pent-2-enylcyclopent-3-en-1-yl)octanoic acid","Quillaic acid","4-Hydroxyphenyl acetate","[(3S,4R,5S)-5-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-hydroxyphenoxy)oxan-3-yl]oxy-3,4-dihydroxyoxolan-3-yl]methyl 4-hydroxybenzoate","Glutamylphenylalanine","1-Palmitoylphosphatidylcholine","12,15-dihydroxy-3-(pentopyranosyloxy)-, (24E)-9,19-cyclolanost-24-en-26-oic acid","Ketoprofen","Neomangiferin","Cylindrol B","Kaempferol 3,7,4'-trimethyl ether","Araloside A","Diphenyl phosphate","Glycyrrhizic acid","Oleanolic acid base + O-HexA-Hex","4-Methoxycinnamic acid","2-[4-[4-[Hydroxy-(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)oxolan-2-yl]-2-methoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol","D-Pinitol","Vanillic acid","Glyceric acid","Euscaphic acid","Flemiphilippinin A","16-Hydroxy-3-(beta-D-xylopyranosyloxy)-, (3beta,5xi,9xi,16alpha)-olean-12-ene-23,28-dioic acid","Hexadecanedioic acid","[(2R,3R,4S,6S)-6-[(2R,3S,4R)-6-[(2R,3R,4R,6S)-6-[[(2S,3S)-3-[(1S,3S,4R)-3,4-Dihydroxy-1-methoxy-2-oxopentyl]-6-[(2S,4R,5R,6R)-4-[(2S,4R,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-5-methoxy-6-methyloxan-2-yl]oxy-8,9-dihydroxy-7-methyl-1-oxo-3,4-dihydro-2H-anthracen-2-yl]oxy]-3-hydroxy-2-methyloxan-4-yl]oxy-3-hydroxy-2-methyloxan-4-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] acetate","Retrochalcone","Phthalic acid","3-Hydroxy-6-[(9-hydroxy-4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,7,8,9,10,12,14a-dodecahydropicen-3-yl)oxy]-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-5-(3,4,5-trihydroxyoxan-2-yl)oxyoxane-2-carboxylic acid","beta-D-Fructofuranosyl 6-O-(4-hydroxybenzoyl)-alpha-D-glucopyranoside","7-O-Methylquercetin-3-O-galactoside-6''-rhamnoside","Alanylphenylalanine","9-Hydroxy-5b,8,11a-trimethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a,5a,8-tricarboxylic acid","Cyclic AMP","3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid","Kaempferol-3-O-glucoside-6''-p-coumaroyl","Isorhamnetin","Naringin","2'-Adenylic acid","4-Hydroxyquinoline","Retusin 7-methyl ether","Uridine","Imazamox","9-Oxo-11-(3-pentyloxiran-2-YL)undec-10-enoic acid","3'-Adenylic acid","Benzoic acid + 1O, 2MeO, O-Hex","[3,4,5-Trihydroxy-6-(hydroxymethyl)oxan-2-yl] 10-[3-hydroxy-6-(hydroxymethyl)-5-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-4-(3,4,5-trihydroxyoxan-2-yl)oxyoxan-2-yl]oxy-6a,6b,9,9,12a-pentamethyl-2-methylidene-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate","Chenodeoxycholic acid","N-Acetyl-DL-tryptophan","Furostane base -2H + O-Hex","PI 35:2","3-(Hexopyranosyloxy)-2-hydroxypropyl ester, (9Z,12Z,15Z)-9,12,15-octadecatrienoic acid","Bavachin","Benzothiazole-2-sulfonic acid","D-Glucose","Polygalaxanthone III","Serine","Proline","Iristectorigenin B","Leucanthoside","Microcystin YR","Benzoic acid + 2O, O-Hex","2,5-Dihydroxybenzoic acid","Altanserin","Peonidin 3-(6''-acetyl)glucoside","5'-Deoxy-5'-methylthioadenosine","4-Malonyl ononin","Ononin","1,7-Bis(4-hydroxyphenyl)-3-heptanyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-beta-D-glucopyranoside","Tridecanoic acid","Thiopental","Medicarpin 3-O-glucoside-6'-malonate","Aspartic acid","Liquiritin","Soyasapogenol B base + O-HexA-Hex-Pen, O-C6H7O3(DDMP)","Indole-3-acetic acid","Uralenneoside","Formononetin 7-O-glucoside-6''-O-malonate","(3beta,5xi,9xi,16alpha,21beta,22alpha)-21,28-Diacetoxy-16,22,24-trihydroxyolean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->4)]-beta-D-glucopyranosiduronic acid","FA 18:0+2O+SO4","Primuliten","Linoleic acid","Eupatilin","Fumaric acid","(2S,3S,4S,5R,6R)-6-[[(2S,3R,4R,6Ar,6bS,8aS,12aS,14bR)-4-formyl-2-hydroxy-4,6a,6b,11,11,14b-hexamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid","Matairesinol","(1S,2R,4As,6aR,6bR,10S,12aR,14bS)-1,2,6b,9,9,12a-hexamethyl-10-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a,6a-dicarboxylic acid","4-Hydroxycoumarin","Carboxyibuprofen","Baicalein","[(2R,3R,4R,6S)-6-[[(6S,7S)-6-[(2S,4R,5R,6R)-4-[(4R,5S,6R)-4-[(2S,4S,5R,6R)-5-Acetyloxy-4-hydroxy-4,6-dimethyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-7-[(1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-4,10-dihydroxy-3-methyl-5-oxo-7,8-dihydro-6H-anthracen-2-yl]oxy]-4-[(2S,4R,5S,6R)-4-hydroxy-5-methoxy-6-methyloxan-2-yl]oxy-2-methyloxan-3-yl] acetate","2-Picenecarboxylic acid","PI 36:5","PI 36:4","Triamcinolone","PI 36:2","Sulfo jasmonate","(12Z)-9,10-Dihydroxyoctadec-12-enoic acid","Ginsenoside Rf","Phenylpyruvic acid","3,5,5-Trimethyl-4-[3-[(6-O-beta-D-xylopyranosyl-beta-D-glucopyranosyl)oxy]butyl]-2-cyclohexen-1-one","Totarol","4-Methoxybenzoic acid","Daidzin","Soyasapogenol B base + O-HexA-Pen-dHex, O-C6H7O3","Sucrose","D-Ribulose 5-phosphate","Methyl (3R,4R,5R)-5-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(E)-3-phenylprop-2-enoyl]oxyoxan-2-yl]oxy-3,4-dihydroxycyclohexene-1-carboxylate","Methylsuccinic acid","Ala-Leu","Formononetin-7-O-glucoside","3-Hydroxy-N-(2-oxooxolan-3-yl)tetradecanamide","Butein","Chikusetsu saponin IVa","Norcimifugin","Phlorizin","2-Azaniumyl-3-(1H-indol-3-yl)propanoate","[3,4,5-Trihydroxy-6-(hydroxymethyl)oxan-2-yl] 4,6-dihydroxy-7,12,16-trimethyl-15-(4,5,6-trihydroxy-6-methylheptan-2-yl)pentacyclo[9.7.0.01,3.03,8.012,16]octadecane-7-carboxylate","Phloretin","(-)-Epicatechin gallate","Dihydroartemisinic acid","Secoisolariciresinol diglucoside","Pentacosanoic acid","Atalaphylline","Medicagenic acid base + O-MalonylHex","3-((3'-Malonyl)Xyl)-28-Glu Bayogenin","gamma-Glutamylmethionine","H-DL-xiIle-DL-xiIle-OH","4'-Methoxy-7-O-beta-D-glucopyranosyl-8,3'-dihydroxyflavanone","2-Isopropylmalic acid","l-Isoleucine","13-HODE","19S-Methoxytubotaiwine","Urocanic acid","4-(4-Chloro-2-methylphenoxy)butanoic acid","Amentoflavone","Abietic acid","Nimbidiol","FA 18:2;4O","trans-Cinnamic acid","Lawsone","Ginsenoside Ro","S-Adenosyl-L-homocysteine","FA 20:0;2O","Trehalose-6-phosphate","Sophoricoside","1-Carboxycyclohexaneacetic Acid","Steviolbioside","Biochanin A 7-O-beta-D-glucoside","PI 34:1","Glutamic acid","Spinosin","Methyl gallate","Trehalose","Hydroxybenzotriazole","Medicagenic acid base + O-Hex","Umbelliferone","Ginsenoside Rg2","Pygenic acid b","(2S,3S,4S,5R,6R)-6-(3-benzoyloxy-2-hydroxypropoxy)-3,4,5-trihydroxyoxane-2-carboxylic acid","Ginsenoside Rg5","Coumestrin","Ginsenoside Rg6","Guanine","Cyanidin 3-(2G-glucosylrutinoside)","4-Hydroxy-3-methoxycinnamaldehyde","Alachlor OXA","(2S,3S,4S,5R,6R)-6-[[(2S,3R,4R,6Ar,6bS,8aS,14bR)-2-hydroxy-4-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid","4-Nitrophenol","Hydron;nonanedioate","(1S,4S,8R,14S)-11-Ethyl-12-oxo-7,9,13-trioxatetracyclo[6.5.1.0(1),(1).0,(1)]tetradeca-2,5-diene-5-carboxylic acid","FA 18:3;2O","12,13-Dihydroxyoctadec-9-enoic acid","Eriodictyol","Amatain","Xanthosine","Pyridoxine","Pimelic acid","2,2-Dimethylsuccinic acid","(15Z)-9,12,13-Trihydroxy-15-octadecenoic acid","Adenosine 2',3'-cyclic phosphate","(1R,3aS,5aR,5bR,11aR,13aR)-7-hydroxy-5a,5b,8,8,11a-pentamethyl-9-oxo-1-prop-1-en-2-yl-2,3,4,5,6,7,7a,10,11,11b,12,13,13a,13b-tetradecahydro-1H-cyclopenta[a]chrysene-3a-carboxylic acid","3-Glu-28-Xyl(1-4)Rha(1-2)Ara Medicagenic acid","Emodin","9-Hydroxy-11-[3-hydroxy-5-(1-hydroxypropyl)oxolan-2-yl]undec-10-enoic acid","Syrosingopine","Cynaroside","5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one","Gentiobiose","FA 18:3;3O","Coixol","gamma-Mangostin","FA 36:10","Verbascoside","Novobiocin","P-Toluenesulfonic acid","PI 34:2","FA 20:2","FA 20:1","FA 20:4","L-beta-Homotyrosine","FA 20:3","5-[2-(Furan-3-yl)ethyl]-8-hydroxy-5,6,8a-trimethyl-3,4,4a,6,7,8-hexahydronaphthalene-1-carboxylic acid","1-O-[(3beta,5xi,9xi,18xi)-3-[(3-O-beta-D-Galactopyranosyl-beta-D-glucopyranuronosyl)oxy]-28-oxoolean-12-en-28-yl]-beta-D-glucopyranose","Galangin","Theobromine","Plantamajoside","Medicagenic acid","Hydron;2-hydroxypropane-1,2,3-tricarboxylate","Phytolaccagenin","4-Methyl-2-oxopentanoic acid","Cinobufagin","Pipecolic acid","Dormin","4-Methyl-5-oxo-2-tridecyl-2H-furan-3-carboxylic acid","Isorhamnetin-3-O-galactoside-6''-rhamnoside","Glucose 6-phosphate","FA 18:1;2O","Oseltamivir acid","6-Hydroxyapigenin","Stachyose","Stearic acid","Jasmonic acid","9-Oxononanoic acid","Warfarin","Meglutol","Pyroglutamylisoleucine","(3S)-5-[(1R,2R,8aS)-2-hydroxy-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]-3-methylpentanoic acid","Pioglitazone","7-Hydroxy-3-methylflavone","Glycylisoleucine","(Z)-5,8,11-Trihydroxyoctadec-9-enoic acid","Esculetin","Ginsenoside Rh1","2-Hydroxyanthraquinone","Heneicosanoic acid","Cytidine","Soyasapogenol B + dHex + Hex + HexA + malonyl","Carviolin","Cirsimaritin","1-O-[(3beta,5xi,9xi)-3-(beta-D-Glucopyranuronosyloxy)-30-methoxy-28,30-dioxoolean-12-en-28-yl]-beta-D-glucopyranose","Ginkgolic Acid C15:1","6''-O-L-Arabinopyranosylastragalin","FA 18:1;3O","Apigenin-6-C-arabinoside-8-C-glucoside","6-Deoxy-alpha-L-mannopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-1-O-[(3beta)-3,23-dihydroxy-23,28-dioxoolean-12-en-28-yl]-beta-D-glucopyranose","6'-O-P-Coumaroylgenipin gentiobioside","[6-[2-(3,4-Dihydroxyphenyl)ethoxy]-2-(hydroxymethyl)-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-5-(3,4,5-trihydroxyoxan-2-yl)oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate","Cohumulone","Asiatic acid","(13-Methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl) hydrogen sulfate","Methyl heptadecanoate","7,3',4'-Trihydroxyflavone","[2-Hydroxy-3-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxypropyl] octadeca-9,12,15-trienoate","Soyasapogenol B base + O-HexA-Pen","(2S,3S,4R,5R,6R)-6-[[(3R,6Ar,6bS,8R,8aR,14bR)-8-hydroxy-4,4,6a,6b,11,11,14b-heptamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4,5-dihydroxy-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxane-2-carboxylic acid","[(2R,3S,4S,5R,6R)-6-[1,7-Bis(3,4-dihydroxyphenyl)-5-oxoheptan-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl (E)-3-(3,4-dimethoxyphenyl)prop-2-enoate","Bayogenin base + O-Hex-Hex","Docosanoic acid","10-Hydroxydecanoic acid","2'-Methoxyformonetin","Gypsogenin-3-O-glucuronide","3-[(2-O-Hexopyranosylpentopyranosyl)oxy]-12,15-dihydroxy-, (3beta,8xi,9beta,24E)-9,19-cyclolanost-24-en-26-oic acid","3,7-Dimethoxyflavone","Xanthopurpurin","Hispidulin 4'-glucoside","Cy 3-coumSamb-5-Glc","cis-Aconitic acid","8-Desoxygartanin","9,12,13-Trihydroxyoctadec-10-enoic acid","Luteolin-7-O-glucoside","NP-000062(6)","Chrysin-7-O-glucuronide","3',4',4'a,5',6,6',7',8,8',8'a-Decahydro-4,6',7'-trihydroxy-2',5',5',8'a-tetramethyl-6-oxo-, (2R,2'R,6'S,7'R,8'aS)-spiro[2H-furo[2,3-e]isoindole-2,1'(2'H)-naphthalene]-7(3H)-butanoic acid","Macranthoside B","Pelargonic acid","Cyproterone","Hyodeoxycholic acid","(2S,3S,4S,5R,6R)-6-[[(3S,6Ar,6bS,8aS,14bR)-4,4,6a,6b,11,11,14b-heptamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid","Dipalmitoylphosphatidylglycerol","Dodecylbenzenesulfonic acid","Jujuboside B","Tricin 5-glucoside","Crategolic acid","Speciofiline","Butylated hydroxytoluene","Quercetin-3,4'-O-di-beta-glucoside","Sinomenine","1,7-Bis(4-hydroxyphenyl)hept-1-en-3-one","Anthranilic acid","1H-Benzotriazole-5-carboxylic acid","Soyasapogenol B base + O-HexA-Pen-dHex","Naringenin","Hydron;2-methylidenebutanedioate","Embelin","Licochalcone A","5-(5-Methoxycarbonyl-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl)-3-methylpentanoic acid","3,4-Dihydroxyphenylacetic acid","9-Hydroperoxy-, (Z,Z,Z)-10,12,15-octadecatrienoic acid","3-Methylbenzoate","Raddeanin A","2-[2-[5-[4-[4,5-Dihydroxy-6-methyl-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxy-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]-3-methylpent-1-en-3-yl]oxy-5-hydroxy-6-methyl-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-4-yl]oxy-6-methyloxane-3,4,5-triol","3,4-Dihydroxybenzoic acid","1,2-Dipalmitoyl-sn-glycerol 3-phosphate","N,N-Dimethylguanosine","Ochnaflavone 4'-methyl ether","9-(2,3-Dihydroxypropoxy)-9-oxononanoic acid","(2S,3S)-4-Methylidene-5-oxo-2-tridecyloxolane-3-carboxylic acid","L-Threonine","(1S,4aS,7S,7aS)-1-[(2S,3R,4S,5S,6R)-6-[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl]oxy-7-hydroxy-7-methyl-4a,5,6,7a-tetrahydro-1H-cyclopenta[c]pyran-4-carboxylic acid","Eprosartan","Kynurenic acid","[(2S,3R,4R,5S,6S)-2-[[(1aS,1bS,2S,5aR,6S,6aS)-1a-(hydroxymethyl)-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,5a,6,6a-tetrahydro-1bH-oxireno[5,6]cyclopenta[1,3-c]pyran-6-yl]oxy]-3,5-dihydroxy-6-methyloxan-4-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate","Isoliquiritigenin","Pyridoxal","(4As,6aS,6bR,8R,9R,10R,11R,12aR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid","Ursonic acid","Echinocystic acid-3-O-glucoside","Methionine","28-Dioic acid, 3-[(6-deoxy-4-O-beta-D-glucopyranosyl-alpha-L-mannopyranosyl)oxy]-, (3beta,5xi,9xi,18xi)-urs-12-ene-27","Hispidulin","Catechol","9-Hydroxy-10E,12Z-octadecadienoic acid","Enoxolone","5-[2-(3-Furyl)ethyl]-8a-(hydroxymethyl)-5,6-dimethyl-3,4,4a,5,6,7,8,8a-octahydro-1-naphthalenecarboxylic acid","(Sulfonatoazaniumyl)cyclohexane","delta(4)-Dafachronic acid","5,3'-Dihydroxyflavone","trans-Vaccenic acid","Isobavachalcone","Isoflavanone base + 3O, O-Hex","Pulvinic acid","Calycosin","2-[5-Hydroxy-4-methoxy-6-[4-methoxy-6-[4-methoxy-6-[4-methoxy-2-methyl-6-[[(3S,10R,11S,12S,13S,14S,17S)-11,12,14-trihydroxy-17-[(1S)-1-hydroxyethyl]-10,13-dimethyl-1,2,3,4,7,8,9,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-yl]oxy]oxan-3-yl]oxy-2-methyloxan-3-yl]oxy-2-methyloxan-3-yl]oxy-2-methyloxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol","Osajin","2-Naphthalenesulfonic acid","Tectoridin","Lactulose","Coatline B","Gypenoside XLIX","Medicarpin","alpha-Chaconine","Hexose + C13H21O2","Pseudobaptigenin","Irisxanthone","Rhoifolin","Hydron;propanedioate","2-Hydroxydocosanoic acid","Pedunculoside","Sulfadimethoxine","Obtusifolin","Hydron;pyridine-3-carboxylate","Isoliquiritin","Pentadecanoic acid","Secoisolariciresinol","FA 16:0;2O","p-Coumaraldehyde","Phenylalanine","gamma-Glu-leu","Methoxyluteolin","Glycitin","5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one","Lauryl sulfate","Ferulic acid","Zeranol","3-Hydroxynonanoic acid","(2S,3R,4S,6Ar,6bS,8aS,12aS,14bR)-2-acetyloxy-8a-[(2S,3R,4S,5S,6R)-6-[[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxymethyl]-4,5-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxycarbonyl-3-hydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-4-carboxylic acid","Isoreserpin","Naringenin-7-O-rutinoside","12-Hydroxydodec-3-enoic acid","(1R,2S,5aR,5bR,7aS,10R,12bR)-2-Hydroxy-10-isopropenyl-3,3,5a,5b,12b-pentamethyloctadecahydrodicyclopenta[a,i]phenanthrene-1,7a(1H)-dicarboxylic acid","Isoorientin","1-O-Galloyl-6-O-cinnamoylglucose","(2R,3S,4S,5R,6R)-2-[[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-6-[4-(4-hydroxyphenyl)butan-2-yloxy]oxane-3,4,5-triol","Eicosapentaenoic acid","Corynanthine","12-Acetoxyganoderic acid","Rhein","3a-[(2S,3R,4S,5R,6R)-3,5-dihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxycarbonyl-9-hydroxy-5b,8,8,11a-tetramethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-5a-carboxylic acid","Isovitexin","3-Rha-Gal-GluA-22-DDMP Soyasaponenol B","3,5-Dimethyl-4-(methylsulfonyl)-phenol","Ala-Ile","Sinapic acid","5,7-Dihydroxychromone","(2-Hydroxy-3-octadeca-9,12,15-trienoyloxypropyl) 2-(trimethylazaniumyl)ethyl phosphate","Gossypol","Protohypericin","2-(beta-D-Glucopyranosyloxy)benzyl 1,6-dihydroxy-2-cyclohexene-1-carboxylate","Cosmosiin","Aleuritic acid","Inosinic acid","[6-(Furan-3-yl)-6,8,12,16,21-pentahydroxy-7,15-dimethyl-9-oxo-3,17,19-trioxaheptacyclo[9.9.3.01,10.02,4.02,7.011,18.015,23]tricosan-14-yl] 2-methylbutanoate","Fluvastatin","Bilobetin","2-Phenyl-3H-benzimidazol-1-ium-5-sulfonate","3-Methyluridine","(2E,4E)-12-[(10E,12E)-13-Carboxy-3-hydroxy-2-(hydroxymethyl)-8,10,12-trimethyltrideca-10,12-dienoyl]oxy-13-(hydroxymethyl)-3,5,7-trimethyltetradeca-2,4-dienedioic acid","Scolymoside","Heterophyllin B","(9Z,15Z)-12,13-Dihydroxyoctadeca-9,15-dienoate","Jaceosidin","Tyrosine","2-Azaniumylethyl (2-hydroxy-3-octadec-9-enoyloxypropyl) phosphate","Octyl gallate","(4aS,6aS,6bR,9R,10S,12aR,14bS)-10-[(2S,3R,4S,5S)-3-[(2S,3R,4R,5S,6S)-3,5-dihydroxy-6-methyl-4-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]oxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid","Gallic acid","Purpurin","Arillatose B","(2S,3S,4S,5R,6R)-6-[[(3S,6aR,6bS,8aS,14bR)-8a-carboxy-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3-hydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxane-2-carboxylic acid","Erythromycin","L-Malic acid","2-Methyl-4-oxo-heptadecanoic acid","(2R,3S,4S,5R,6S)-2-[[(2S,3R,4R)-3,4-Dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-6-(3,4,5-trimethoxyphenoxy)oxane-3,4,5-triol","Spermine","Brazilin","Myristic acid","8-hydroxyoctadeca-9,12,15-trienoic acid","2',6'-Dihydroxy-4-methoxychalcone-4'-O-neohesperid","Succinic acid","Phosphatidylcholine lyso 18:3","3-Glu(1-3)Glu-28-Glu Medicagenic Acid","Apigeninidin","1-(4-Hydroxyphenyl)-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropan-1-one","Hexanedioate;hydron","2,4-Dinitrophenol","gamma-Linolenic acid","Calcium pantothenate","3',4',5,8-Tetrahydroxy-7-methoxy-flavonol 3-O-alpha-l-rhamnopyranoside","Linarin","Quercetin-3-O-vicianoside","Phosphatidylcholine lyso 18:1","Phosphatidylcholine lyso 18:2","Dehydrotumulosic acid","Pristimerin","1-(Aminomethyl)cyclohexaneacetate","Aurantio-obtusin beta-D-glucoside","(1alpha,2alpha,3beta,5xi,9xi,13xi,14xi,18xi)-1,2,3,22,23,29-Hexahydroxy-13,27-cycloolean-11-en-28-oic acid","Dihydroquinine","Liquiritigenin","2-Azaniumylethyl (3-hexadecanoyloxy-2-hydroxypropyl) phosphate","Resveratrol","Tricosanoic acid","Velutin","Roccellic acid","12:4+3O Fatty acyl hexoside","Medicagenic acid base + O-HexA","3,7-Di-O-methylquercetin","N-(4-hydroxybenzoyl)valyl-N-(2-carboxy-6-hydroxyphenyl)-prolinamide","isorhamnetin-3-glucoside-4'-glucoside (Isorhamnetin 3,4'-diglucoside)","Canrenone","Adenine","FA 21:0;2O","Threonic acid","Neotame","3-Hydroxyflavone","(2-Hydroxy-3-octadeca-9,12-dienoyloxypropyl) 2-(trimethylazaniumyl)ethyl phosphate","4-Methoxysalicylic acid","Palmitoleic acid","Kanzonol C","Heptadecanoic acid","Pachymic acid","Benzyl alcohol + Hex-Pen","Reichsteins Substance S","Luteolin 7-O-rutinoside","4',6-Dihydroxyflavone","Glutamine","Luteolin-4'-O-glucoside","Madecassoside","3-Hydroxyphenylacetic acid","Corchorifatty acid F","N-Acetyl-L-phenylalanine","Toxin HT 2","Isoginkgetin","1,10a-Dihydroxy-4,4,7,11b-tetramethyl-2,3,4,4a,5,6,6a,7,10a,11,11a,11b-dodecahydrophenanthro[3,2-b]furan-9(1H)-one","(3beta,5xi,9xi,22beta)-22,24,29-Trihydroxy-29-oxoolean-12-en-3-yl 6-deoxy-alpha-L-mannopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucopyranosiduronic acid","Hydron;tetradecyl sulfate","Isorhapontin","Palmitic acid","Arachidonic acid","16-Hydroxy-9-oxooctadeca-10,12,14-trienoic acid","Voacamine","(4As,6aS,6bR,10S,12aR)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid","[4-[4,5-Dihydroxy-6-methyl-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-[2-(3,4-dihydroxyphenyl)ethoxy]-3,5-dihydroxyoxan-2-yl]methyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate","Histidine","PG 34:1","Hydron;benzoate","Vitamin E","PG 34:3","PG 34:2","Coniferyl aldehyde","4-Hydroxycinnamic acid","Ethylmalonic acid","Demethylwedelolactone","Sinapaldehyde","Acetylleucine","Nervonic acid","Apigenin 7-O-glucosylglucoside","12-Hydroxydodecanoic acid","(1R,9R)-3,4,9-Trihydroxy-11,11-dimethyl-5-propan-2-yl-16-oxatetracyclo[6.6.2.01,10.02,7]hexadeca-2,4,6-trien-15-one","Flavanone base + 3O, O-Hex","Vanillylmandelic acid","Polygalic acid","N-Acetyl-DL-methionine","PE 34:3","Soyasapogenol B base + O-HexA-Hex-Pen","PE 34:2","Sebacic acid","Soyasapogenol B base + O-HexA-HexA-Hex+Me+Acetyl","1-O-[(2alpha,3beta,5xi,9xi)-3-(Hexopyranuronosyloxy)-2-hydroxy-28-oxoolean-12-en-28-yl]hexopyranose","Melezitose","Guan-fu base Y","4-Vinylphenol","Formononetin","2-Dodecoxyethyl hydrogen sulfate","Maslinic acid","alpha-Hederin","3-Phenoxybenzoic acid","alpha-D-Glucopyranoside, alpha-D-glucopyranosyl, 3-(2-methylbutanoate)","Kaempferol 3,7-diglucoside","2-(3,4-Dimethoxyphenyl)-7-hydroxy-4H-chromen-4-one","Naringin dihydrochalcone","3-[(2S,3R,4S,5R,6R)-3-[(2S,3S,4R,5R,6S)-3,5-Dihydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4,5-dihydroxy-6-methyloxan-2-yl]oxy-8-hydroxy-15-methyl-11,18-dioxapentacyclo[10.6.2.02,7.09,19.016,20]icosa-1(19),2(7),3,5,8,12(20),13,15-octaene-10,17-dione","Peonidin-3-glucoside","1,4-Cyclohexanedicarboxylic acid","Dronedarone","Echinocystic acid","24(R)-Pseudoginsenoside F11","Sulfamethoxazole","Apigenin","Sulisobenzone","Saponarin","5-Hydroxy-3',4'-dimethoxyflavanone","Microcystin LW","Danthron","Luteolin","Feruloyl Lactate","L-Pyroglutamic acid","2-(3,4-Dimethoxyphenoxy)-6-[(3,4,5-trihydroxyoxan-2-yl)oxymethyl]oxane-3,4,5-triol","Salicylic acid","Biochanin A","Benzoylformic acid","(1S,2R,4As,6aS,6bR,10S,12aR)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid","Dodecanedioic acid","1,5-Dicaffeoyl quinic acid","(3beta,5xi,9xi)-23-Hydroxy-16-oxo-13,28-epoxyoleanan-3-yl beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranosyl-(1->4)-alpha-L-arabinopyranoside","Ginsenoside F2","Tryptophan","Ginsenoside F3","Magnolol","9,12,13-Trihydroxyoctadeca-10,15-dienoic acid","Xanthine","Isorhamnetin-3-O-glucoside","6,10a-Dihydroxy-4-(hydroxymethyl)-4,7,11b-trimethyl-1,2,3,4a,5,6,6a,7,11,11a-decahydronaphtho[2,1-f][1]benzofuran-9-one","Vaccarin","Gingerol","Asparagine","N-Phenylacetylaspartic acid","3-Dehydrocholic acid","2,3,6-Trichloro-5-cyano-4-hydroxybenzamide","[2-Hydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl] octadeca-9,12-dienoate","Oroxylin A","3-(4-Hydroxyphenyl)-2-propenoic acid","Vitexin","PG 36:3","Diosmetin","PG 36:2","PG 36:4","13-Oxotrideca-9,11-dienoic acid","7-[4,5-Dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one","9-Hexadecenoic acid","3-Hydroxy-3',4'-dimethoxyflavone","Hederagenin base + O-AcetylHex","Tetrasaccharides (Hex-Hex-Hex-Hex)","13-HoTrE","3-((3'-Malonyl)Xyl)-28-Glu-2-hydroxy oleanolic acid","Gluconic acid","8-[3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one","PE 36:4","Medicagenic acid base -H2O + O-HexA","Acacetin","Galactaric acid","4-Hydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1H-benzo[f][2]benzofuran-3-one","Malvidin 3-O-glucoside","PE 36:3","FA 18:4;O","PE 36:2","6a,7,8-Trihydroxy-3-methyl-3,4,5,6,7,12a-hexahydro-2H-benzo[a]anthracene-1,12-dione","Decahydrogambogic acid","Saikosaponin b2","Gly-Pro","Wedelolactone","FA 22:1;2O","6-O-beta-D-Glucopyranosyl-1-O-[(3beta,5xi,9xi)-3,19,24-trihydroxy-24,28-dioxours-12-en-28-yl]-beta-D-glucopyranose","(2-Hydroxy-3-octadec-9-enoyloxypropyl) 2-(trimethylazaniumyl)ethyl phosphate","1-O-[(3beta,5xi,9xi,18xi)-3,19,24-trihydroxy-24,28-dioxours-12-en-28-yl]-hexopyranose","2-Mercaptobenzothiazole","Coronaric acid","Salicylic acid glucoside","3,4-Dihydrocoumarin","(2Z)-4,6-Dihydroxy-2-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-1-benzofuran-3-one","1-Myristoyl-sn-glycerol 3-phosphate","Ginsenoside Rh2 (S-FORM)","2-[4-[(3R,5R,6S,8S,9S,14S,17R)-3,6-Dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid","(R)-2-Hydroxystearic acid","4-Hydroxy-2,5,6-trichloroisophthalonitrile","Puerarin","Coatlin A","Raffinose","4-Hydroxyphenylpyruvic acid","O-Hydroxychalcone","Fortunellin","9,10-Epoxystearic acid","4-(Decan-4-yl)benzenesulfonic acid","2-[4-[3-[3,4-Dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-7-hydroxy-2,3-dihydrochromen-4-one","(S)-7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-en-1-yl)chroman-4-one","Aurantio-obtusin","Baicalin","(E)-1-(3,4-Dihydroxy-2,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one","Corosolic acid","Feruloylcholine","Topotecan","Acebutolol","(2S,3S,4S,5R,6R)-6-[[(3S,6Ar,6bS,8aS,14bR)-8a-carboxy-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid","FA 24:0;2O","Bayogenin","Deoxycholic acid","2,3-Dihydroxybenzoic acid","FA 28:7","Lactose","Xyl(b1-6)Glc(b)-O-octyl","Hymecromone","Linolenic acid","2'-Deoxyguanosine","Chrysin","Santin","1-O-[(3beta,5xi,9xi,18xi)-3-(beta-D-Glucopyranuronosyloxy)-23-hydroxy-28-oxoolean-12-en-28-yl]-beta-D-glucopyranose","Licoagroside B","Estrone","Daidzein","Vanillin","Dinoseb","Asiaticoside"],"additional_accession":[]},"is_claimable":false,"name":"Metabolo-transcriptomics analyses reveal alfalfa adaptation to combined saline-alkali and low-temperature stress in the field","description":"Metabolomics analysis revealed specific accumulation of amino acids, organic acids, carbohydrates, fatty acids and flavonoids in ZD compared with that in BM. The core differential metabolites associated with ZD stress resistance included isoleucine, fumaric acid, raffinose and isovitexin. Integrated metabolomics and transcriptomics analysis highlighted flavonoid, carbohydrate, glutathione and salicylic acid biosynthesis as key pathways in alfalfa stress response.
","dates":{"publication":"2025-06-19","submission":"2025-06-19"},"accession":"MTBLS12611","cross_references":{}}