The MS and MS/MS spectra were matched with the HMDB (http://www.hmdb.ca/) and Metlin (https://metlin.scripps.edu/) databases to identify metabolites.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - negative - reverse phase","Liquid Chromatography MS - positive - reverse phase"],"chromatography_protocol":["The pretreated samples were analyzed using an Ultra-high Performance Liquid Chromatography with quadrupole time-of-flight mass spectrometry (UPLC-TripleTOF) system (AB SCIEX). The samples were separated using a BEH C18 chromatography column (100 mm*2.1 mm i.d., 1.8 µm) and detected via mass spectrometry. The mass spectrometry signal was acquired in positive and negative ion scanning modes, with a mass-to-charge ratio (m/z) range of 50–1000.
"],"publication":["Composite polyphenols mitigate microplastic exposure-related immune disturbances: a two-phase population trial."],"submitter_affiliation":["Fudan University"],"submitter_name":["Ruihua Dong"],"organism_part":["blood plasma"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["100 μL of plasma sample was added to a 1.5 mL centrifuge tube, followed by 400 μL of extraction solution (acetonitrile: methanol = 1:1). The mixture was vortexed and subjected to low-temperature ultrasonic extraction for 30 minutes (5 °C, 40 KHz). The sample was then incubated at -20 °C for 30 minutes, centrifuged at 4 °C for 15 minutes at 13000 g, and the supernatant was transferred. The supernatant was dried under nitrogen gas and reconstituted with 100 μL of reconstitution solution (acetonitrile: water = 1:1). After another 5 minutes of ultrasonic extraction (5 °C, 40 KHz), the sample was centrifuged at 4 °C for 10 minutes at 13000 g, and the supernatant was collected for subsequent analysis.
"],"organism":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS12863"],"author":["Dong Hua. School of Public Health, Fudan University. No. 130, Dong'an Road, Xuhui District, Shanghai. ruihua_dong@fudan.edu.cn. 15800650952."],"data_transformation_protocol":["Raw data were imported into the Progenesis QI software (Waters Corporation, Milford, USA) for processing, generating a data matrix containing retention time, m/z, and peak intensity.
"],"study_factor":["Group"],"submitter_email":["ruihua_dong@fudan.edu.cn"],"sample_collection_protocol":["Blood samples were collected by trained professionals using EDTA anticoagulant tubes through venipuncture to obtain 20 mL of blood. Participants were asked to rest for at least 5 minutes before blood collection. After collection, the plasma was separated by centrifugation at 3000 rpm for 10 minutes at 4 °C.
"],"omics_type":["Metabolomics"],"study_design":["metabolomic profiling","Multiomics","Microplastics"],"curator_keywords":["metabolomic profiling","Multiomics","Microplastics"],"mass_spectrometry_protocol":["The mass spectrometry signal acquisition of the sample was carried out in positive and negative ion scanning mode, with a mass scanning range of m/z: 70-1050. The ion spray voltage was 3500 V for positive ions and -3000 V for negative ions. The sheath gas was 50 arb, the auxiliary heating gas was 13 arb, the ion source heating temperature was 450℃, and the collision energy was cycled at 20-40-60 V.
"],"metabolite_name":["Oxyphencyclimine","Dg(18:4(6z,9z,12z,15z)/15:0/0:0)","G-Glu-Val","LysoPC(20:3(8Z,11Z,14Z)/0:0)","2,6-Dimethyl-4-hydroxybenzaldehyde","[(2R,3R,4R)-3,4,5-Trihydroxy-1-oxopentan-2-yl] (2R)-2-amino-3-sulfanylpropanoate","GPEtn(14:0/22:4)","Oct-5-enedioylcarnitine","Caprolactam","Phenylacetylglutamine","Bufadienolide","3(2H)-Pyridazinone","Indole-3-Carbinol","Ethylenediaminetetraacetic acid","Cer(t18:0/20:3(6,8,11)-OH(5))","Pc(34:2)","Dg(15:0/18:2(9z,12z)/0:0)","3-Oxo-alpha-ionol","Pc(16:0/18:3(9z,12z,15z))","N-Succinyl-2-amino-6-ketopimelate","Chlorobenzene","Cholestan-3-one","Polidocanol","SM(d18:1/16:1(9Z))","Nigrosporapyrone d","Anisperimus","Citrulline","Laminine","Carboprost","DG(20:5(5Z,8Z,11Z,14Z,16E)-OH(18R)/i-14:0/0:0)","Tributyl citrate","GPCho(20:2/20:5)","5alpha-Androst-16-en-3alpha-ol","Thiazole","Phosphatidylcholine alkyl 16:0-22:6","Pc(p-18:0/13:0)","L-isoleucine","GPEtn(20:5/18:1)","GPEtn(14:0/22:2)","L-Tert-Leucine","Pc(18:1/0:0)","Furfural","GPCho(18:3/22:4)","Erbstatin","N-Acetyl-DL-Leucine","Gant61","3-acetyl-2,5-dimethylfuran","Butyrylcarnitine","4-ethynylaniline","Pe(p-16:0/0:0)","Sclareol","Pc(22:5(7z,10z,13z,16z,19z)/18:0)","Dg(15:0/0:0/18:3(9,11,15)-oh(13))","5(z),8(z),11(z)-eicosatrienoic acid methyl ester","2-azaniumyloctanoate","2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol","L-norleucine","4-Oxopentanoylcarnitine","Gamma-Glutamyltyrosine","2-Amino-3-(4-hydroxyphenyl)propanal","Cathasterone","N,n'-dicyclohexylthiourea","Decanoyl-l-carnitine","5-nitro-2-(3-phenylpropylamino)benzoic acid","(+/-)-Methamidophos","SN-Glycero-3-Phosphocholine","4-Methylstyrene","GPEtn(16:1/22:4)","LysoPE(0:0/18:2(9Z,12Z))","Isophorone","Pe(p-16:0/22:6(4z,7z,10z,13z,16z,19z))","Proline betaine","N,N-Dimethyldodecylamine-N-oxide","Oleamide","Undecanoylcarnitine","1-Cyclohexene-1-carboxylic acid","2-Cyclopenten-1-one","Pantothenic acid","9-Hydroxydodecanoylcarnitine","12-methyltridecanoic acid","Fluvoxamino acid","Salicylaldehyde","Fosnetupitant","GPCho(18:2/18:2)","2-hydroxycinnamic acid","Octanoylcarnitine","PE-NMe2(20:4(5Z,8Z,11Z,14Z)/18:1(11Z))","Poly thf n5","Morph","Acetoacetic acid","3-Amino-1-hydroxypyrrolidin-2-one","LysoPE(0:0/20:5(5Z,8Z,11Z,14Z,17Z))","Pc(22:6/0:0)","1-dodecyl-2-pyrrolidinone","(2-oxo-2,3-dihydro-1h-indol-3-yl)acetic acid","Biliverdin","Glycylhydroxyproline","Elemicin","2-Methylindole","Leucomalachite green","Methyl beta-orcinolcarboxylate","Asaraldehyde","9(z),11(e)-conjugated linoleic acid","1-oleoyl-2-myristoyl-sn-glycero-3-phosphocholine","Bisulepine","Indole","N-Nervonoyl Cysteine","N-Arachidonoylglycine","Pc(22:5/0:0)","2-benzoxazolinone","Benzamide","Norcholic acid","4-Methylpyrimidine","Isoindoline","3,4-edma","Glutarylcarnitine","GPCho(20:5/20:4)","Dg(22:5(4z,7z,10z,13z,16z)/22:6(4z,7z,10z,13z,16z,19z)/0:0)","Butyraldehyde","Diethanolamine","DG(18:3(10,12,15)-OH(9)/a-15:0/0:0)","3-(Aminomethyl)-2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one","Putreanine","Loliolide","Jasmolone glucoside","L-Valine, N-(2-hydroxy-3-butenyl)-","Indole-3-acetic acid","Peg n14","Pc(16:0/0:0)","Glucosaminic acid","Heptaethylene glycol monododecyl ether","Tridec-8-enoylcarnitine","Peg n12","Alpha-Methylene-Gamma-Butyrolactone","3,5-dihydroxy-4-methoxybenzoic acid","Dihomolinoleic acid","LysoSM(d18:0)","Tetradecyldiethanolamine","Pc(18:2/0:0)","GPCho(20:4/20:4)","Pc(20:4/0:0)","Pc(34:1)","Pe(17:0/0:0)","Cis-3-hexen-1-ol","3-Hydroxy-2-oxoindole","Myristoyl ethanolamide","Uric Acid","L-tyrosine","4-methylcatechol","(Z)-3-Oxo-2-(2-pentenyl)-1-cyclopenteneacetic acid","Myotoxin A","LysoPC(18:4(6Z,9Z,12Z,15Z)/0:0)","Peimine","N-epsilon-acetyl-l-lysine","GPCho(16:0/20:4)","Dg(18:0/18:4(6z,9z,12z,15z)/0:0)","Stearidonic acid","Argatroban","Alanine-betaxanthin","Myristoyllysophosphatidylcholine","D-Glucaro-1,4-lactone","Pc(p-16:0/2:0)","Ecgonine","Candoxatrilat","(2E)-Hept-2-enoylcarnitine","Sphingosine","GPEtn(18:1/16:1)","3-Dehydrosphinganine","(11Z)-Hexadecenoylcarnitine","6-Methoxymellein","Ile phe met","Pc(20:3/0:0)","GPCho(16:0/20:5)","N-Undecanoylglycine","Bis[2-(2-butoxyethoxy)ethyl]hexandioate","Sorbic acid","4-Dodecan-6-ylbenzenesulfonic Acid","Propionylcarnitine","1-(1z-hexadecenyl)-sn-glycero-3-phosphocholine","(9Z,11R,12S,13S,15Z)-12,13-Epoxy-11-hydroxy-9,15-octadecadienoic acid","Lykurim","Biliverdin-IX-alpha","Cer(d18:0/18:0)","Pe(18:0/0:0)","Buprenorphine","Peg n7","Acetaminophen","Oxindanac","MG(i-22:0/0:0/0:0)","N-methyl-2-ai","7-Hydroxyoctanoylcarnitine","Cabergoline","2-Hydroxyestrone-4-S-glutathione","N2-acetyl-l-ornithine","N(6)-Methyllysine","Geranyl acetate","Hexadecanedioic acid mono-L-carnitine ester","LysoPC(16:1(9Z)/0:0)","Bisacurone epoxide","2,5-Heptadien-1-ol","Pc(p-18:0/20:4)","Linoleoyl carnitine","Levoglucosan","3-Phenyl-2-propenyl","3-(Hydroxymethyl)-5,5-diphenylimidazolidine-2,4-dione","Piperine","Rifampicin","L-nil","Benzoic Acid","Coprostanone","Octanoyl-l-carnitine","Hydroxytetradecadienyl-l-carnitine","Ipecoside","Pe(19:1(9z)/0:0)","Creatinine","Indole-3-Carboxaldehyde","N-Acetyl-L-Alanine","Pe(20:4(8z,11z,14z,17z)/p-18:0)","Acetanilide","3,17,20-Trihydroxypregnane","Pc(18:0/0:0)","Exo-2-Methyl-3-methylenebicyclo[2.2.1]heptan-2-ol","2,3-butanedione","Dihomo-gamma-linolenoyl paf c-16","Val Arg Gly","Phthalamic acid","6-methylnicotinamide","Lactose citrate","Cilengitide","P-Coumaric acid sulfate","Ppg n11","Lysopc(15:0)","3,5-di-tert-butyl-4-hydroxybenzyl alcohol","N-Isopropyl-N'-phenyl-p-phenylenediamine","L-Hexanoylcarnitine","13-hotre","Gallamonum","Pyroglutamylproline","Choline glycerophosphate","3-Methyl-5-pentyl-2-furanundecanoic acid","N-Stearoyl Arginine","Tanacetol B","5,6-Dihydrouridine","Tanacetol A","Melanettin","2-octenoyl carnitine","LysoPC(0:0/16:0)","L-histidine","Theobromine","Cortisol","Decamethylcyclopentasiloxane","Glycocholic acid","Phenylalanyltryptophan","Urobilin","Tyrosyl-Lysine","Betaine","5-hydroxyindole","4-hydroxy-2-nonenal-[Cys-Gly] conjugate","Pipecolic Acid","Valine lactate","Pc(17:0/0:0)","Floionolic acid","Fa(18:3+1o)","Carnitine","Hexazinone","13(S)-Hydroperoxylinolenic acid","Indole-3-lactic acid","Isoquinoline","Tryptophol","Mesobilirubinogen","[6-(5-Chloropyridin-2-yl)-7-hydroxypyrrolo[3,4-b]pyrazin-5-yl] 4-methylpiperazine-1-carboxylate","1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine","Para-Phenylenediamine","4-hydroxyphenylglycine","4,5-seco-dopa","(+/-)-Propionylcarnitine","1-Methylhistidine","Dodecanoic acid","Azimexon","Safrole","4-Hydroxy-3-Methoxybenzenemethanol","Methyl 2-amino-3-phenylpropanoate","N-Linoleoyl Methionine","4-Hydroxy-4-(3-pyridyl)-butanoic acid","Pe(p-18:1(9z)/22:6(4z,7z,10z,13z,16z,19z))","4-Pyrimidine Methanamine (hydrochloride)","5-mapdb","Pe(20:3/0:0)","1,3-dicyclohexylurea","Decapropylene glycol","N-hydroxy mda","2-phenylacetamide","2-methylbutyroylcarnitine","Triphenylphosphine oxide","Cer(d18:2(4E,14Z)/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15))","Dihydroorotic Acid","Indoprofen","Thiodiacetic acid","Retaspimycin","3,8-Dihydroxy-6-methoxy-7(11)-eremophilen-12,8-olide","5-Hydroxydec-6-enoylcarnitine","GPCho(22:5/16:1)","Monoolein","APC","1H-Indene-1,2(3H)-dione","PG(i-12:0/i-17:0)","5-(3-Pyridyl)-2-hydroxytetrahydrofuran","Sarcosine","Farnesyl acetone","Dihydrocarvone","GPCho(22:6/16:0)","Ethoxycarbonylmethyl ethyl phthalate","Pro phe","Pinolenic acid","Cynaratriol","Phaeophorbide b","Pc(18:3(9z,12z,15z)/16:0)","5b-Cholestane-3a,7a,12a,23R,25-pentol","Dg(16:0/15:0/0:0)","L-arginine","Longicamphenylone","Tetracosahexaenoic acid","Pe(18:3(6z,9z,12z)/18:1(9z))","1-Hexadecanoyl-sn-Glycero-3-Phosphoethanolamine","3'-Amino-3'-deoxythimidine glucuronide","Methionyl-Isoleucine","27-Deoxy-5b-cyprinol","Oryzalexin E","Dl-dimyristoylphosphatidylcholine","Pc(p-18:0/18:2)","8-Amino-7-oxononanoic acid","SM(d18:0/16:1(9Z))","Netilmicin","Epinepetalactone","L-Leucine","5-(Hydroxyphenyl)-gamma-valerolactone-O-sulphate","(1Ar,3S,4aS,7S,8aS)-3-[(1S,2R,3R)-3-[(2R,5S)-5,6-dimethylheptan-2-yl]-2-(2-hydroxyethyl)-2-methylcyclopentyl]-7-hydroxy-4a-methyl-2,3,5,6,7,8-hexahydro-1aH-naphtho[4,4a-b]oxiren-4-one","Trigonelline","Menthyl ethylene glycol carbonate","2-Azaspiro[4.5]decan-3-one","2,4-dimethylhexanedioylcarnitine","Glycerol","Phytuberin","Lyso-pc(18:0)","Lauroylcarnitine","Pyrenocin c","2-hydroxyphenylalanine","Styrene","GPCho(22:6/18:0)","SM(d18:1/18:1(12Z)-2OH(9,10))","Ubiquinone-1","Edetic acid","2-(4-morpholinyl)benzothiazole","GPCho(18:4/20:3)","PE-NMe2(16:1(9Z)/22:5(7Z,10Z,13Z,16Z,19Z))","Butylisopropylamine","1,3-benzodioxolylbutanamine","Pe(18:0/20:4(8z,11z,14z,17z))","Geranylgeraniol","Trans-3-indoleacrylic acid","Arachidonoylcarnitine","3-hydroxy-5,5,8a-trimethyl-3,4,4a,6,7,8-hexahydronaphthalene-2-carboxylic acid","Soyasapogenol D","Withaperuvin H","SM(d15:0/2:0)","Lauryldiethanolamine","Dg(15:0/18:1(12z)-o(9s,10r)/0:0)","3-Hydroxyphloretin 2'-O-xylosyl-glucoside","Octopamine","L-Tryptophan","Triethanolamine","Oleoyl-l-carnitine","(1R,9S)-10-(Cyclopropylmethyl)-12-ethyl-4-hydroxy-13-methyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-8-one","Serotonin","LysoPE(0:0/20:3(8Z,11Z,14Z))","3-hydroxybutyric acid","Prolylhydroxyproline","DG(i-19:0/TXB2/0:0)","N-ethylaniline","Lpe(16:0)","(5R)-5-Hydroxyhexanoylcarnitine","Bis(2-ethylhexyl) sebacate","Cycloleucine","Morpholine","Pe(19:0/0:0)","Pentaethylene glycol","Dibutyl sebacate","Mytilin A","1-aminocyclopropane-1-carboxylate","Uracil","2-Amino-2-methyl-1-propanol","N,n-Dimethylformamide","LysoPC(18:3(6Z,9Z,12Z)/0:0)","GPEtn(20:3/16:0)","1-Butylamine","2-(Methylthio)benzothiazole","3-Methylbenzaldehyde","Atraton","1,5-naphthalenediamine","4-Amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline","1,8-Naphthyridine, 2-fluoro-","D-alanine methyl ester","Creatine","Pc(22:6(4z,7z,10z,13z,16z,19z)/p-16:0)","Sphingosine 1-phosphate","(S)-(-)-Perillyl alcohol","Mjdbissp00000001","Pi(16:0/22:4(10z,13z,16z,19z))","Phytosphingosine","O-(13-Carboxytridecanoyl)carnitine","Nirvanol","Glu Ser","GPEtn(8:0/26:1)","Mjdbissp00000002","Mjdbissp00000009","Lys Leu Gln","Leu phe met","4-methyl-1h-benzotriazole","Cortodoxone","4-hydroxybenzaldehyde","Lenticin","GPCho(20:3/20:3)","Citrusinine I","Eicosapentaenoyl paf c-16","(1(10)E,4a,5E)-1(10),5-Germacradiene-12-acetoxy-4,11-diol","Pro leu","Pe(18:3(6z,9z,12z)/16:0)","1-palmitoyl-sn-glycero-3-phosphocholine","2-[4-[[4-([1,2,4]triazolo[4,3-a]pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]ethanol","Cyclophosphamide","Quisqualic acid","Sm(d18:1/18:1)","GPCho(20:5/16:0)","Cyclohexane","Paraxanthine","(1'R)-Nepetalic acid","Hypoxanthine","13E-Docosenamide","Aplysiatoxin, 17-debromo-","Homoserine","Betaxolol","D-glutamine","S-Butylcysteine sulfoxide","N-[Bis(3-aminopropyl)amino]-N-hydroxynitrous amide","N-Lauroyl Arginine","Phosphatidylcholine lyso 18:0","9-F1-phytoprostane","Kobusone","(4S,8R)-8,9-Dihydroxy-p-menth-1(6)-en-2-one","Pe(p-18:0/18:4)","Choline Phosphate","1,2-dioleoyl-sn-glycerol","(4Z,6Z)-Octa-4,6-dienoylcarnitine","3,4-dimethoxycinnamic acid","Chebi:69439","N-ethyl-n-methylcathinone","Pc(20:3(5z,8z,11z)/18:0)","3-Des(dimethylaminoethyl)-3-acetic acid zolmitriptan","L-Glutamic acid","8-Deoxylactucin","6-methyl-4-(2-thienylmethyl)-2,3-dihydropyridazin-3-one","Deoxycarnitine","Arg-His-Phe-Trp-Gln-Gln","Ala-ile","Octaethyleneglycol monododecyl ether","Adenine","Pe(14:0/20:2(11z,14z))","Thiram","N,n-dimethyltetradecylamine-n-oxide","Bis(2-ethylhexyl) phthalate","Dg(18:3(9z,12z,15z)/18:1(11z)/0:0)","Cortisone","3-hydroxyanthranilic acid","Isobutyric acid","(10Z,12E)-Tetradecadienoylcarnitine","Ala-Ala-Ala","Norvaline betaine","(4E)-3-Hydroxydodec-4-enoylcarnitine","2-mercaptobenzothiazole","6-Hydroxy-8-pentacosanone","LysoPE(0:0/20:4(8Z,11Z,14Z,17Z))","Metipranolol","Beta-Guanidinopropionic acid","Testosterone acetate","(Diaminomethylideneamino) thiocyanate","1-Acetamidocyclopentanecarboxylic acid","Phenylacetic acid","GPCho(17:1/17:2)","3-indolepropionic acid","Pe(18:1(9z)/0:0)","4,5-Dihydrovomifoliol","Pe(lte4/p-18:0)","Pc(32:0)","2-piperidone","Citronellic acid","Subaphylline","Z-Lly-fmk","3,6,9,12,15,18,21,24,27,30-decaoxadotriacontane-1,32-diol","Dimethyl Sulfoxide","N-alpha-Acetyl-L-lysine","N-(2-hydroxyethyl)iminodiacetic acid","Dihydroxyphenyl-valerolactone","GPCho(20:4/16:0)","1-stearoyl-2-linoleoyl-sn-glycero-3-phosphatidylcholine","Caffeine","Phenytoin dihydrodiol","Propionylglycine","Myristoylcarnitine","Pe(15:0/15:0)","Granisetron","Cer(d16:1/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15))","2-[(2S)-2,6-Diaminohexanoyl]oxyacetic acid","3-Hydroxybenzaldehyde","Pe(16:1(9z)/p-18:0)","Pyroglutamic Acid","3-methylglutaconic acid","12-Hydroxydodecanoic acid","Decaethylene glycol","GPEtn(18:4/20:0)","Quercetin 3-O-(6''-acetyl-glucoside)","Tyrosine conjugated cholic acid","L-Methionine","Decylamine Oxide","Nicotinamide","N-Myristoyl Arginine","Octanoate","2-(4-benzhydrylpiperidino)-3-chloro-5-(trifluoromethyl)pyridine","Dihydroroseoside","4-hydroxycinnamic acid","Coniferyl acetate","Propranolol glucuronide","6-methylindole","L-threo-sphinganine","9-Hydroxydecanoylcarnitine","(22R,23R)-22,23-dihydroxycampesterol","N-propyl cinnamate","Carene","Pc(22:6(4z,7z,10z,13z,16z,19z)/p-18:0)","Pc(txb2/14:0)","6alpha-hydroxy-castasterone","(2R,3R,5R)-3,5-Dihydroxy-2-[[(2R)-2-hydroxy-13-methyltetradecanoyl]amino]-15-methylhexadecane-1-sulfonic acid","Thyroxine","Kynurenine","Hymenoxon","1-acetylproline","GPCho(3:0/25:0)","Pc(18:2(9z,12z)/16:0)","Hexamethoxymethyl melamine","(S)-Oleuropeic acid","O-Acetylcarnitine","Cyclopentanol","Etodolac acyl glucuronide","(S)-2-Methyl-1-butanol O-beta-D-Glucopyranoside","Azelnidipine","Propylparaben","1-Isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-6-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-4-carboxamide","Agelasine e/f","Decanoylcarnitine","Pc(p-18:1(9z)/18:4(6z,9z,12z,15z))","N,n-diisopropylethylamine","8-hydroxy-9,10-epoxystearic acid","Choline","Cer(d18:0/20:4(5Z,8Z,11Z,14Z)-OH(18R))","1-(4-chlorophenyl)-2-(4-pyrimidin-2-ylpiperazin-1-yl)ethanol","Docosahexaenoyl GABA","(2S)-2-Amino-3-[(2-chloroacetyl)amino]propanoic acid","Pe(14:1(9z)/22:1(13z))","Gamma-glutamylphenylalanine","Beta-D-Glucopyranuronic acid","3,5,9-Trihydroxyergost-7-en-6-one","Dibenzylamine","4'-Hydroxymethohexital","Acetylcysteine","5-Hydroxyoctanoylcarnitine","Pc(22:6(4z,7z,10z,13z,16z,19z)/p-18:1(9z))","3,4-dihydroxyphenyl ethanol","2-(1,2,3,4-Tetrahydroxybutyl)thiazolidine-4-carboxylic acid","N-(3-Methyl-2-pyridyl)-3-phenylsuccinimide","Gymnodimine","Candicine","Indoline","LysoPE(18:2(9Z,12Z)/0:0)","2-[2-(3,5-dimethoxyanilino)-2-oxoethyl]-1,4-dimethylpyrrole-3-carboxylic acid","N-acetylornithine","Pc(p-16:0/20:4(8z,11z,14z,17z))","N-Docosahexaenoyl Lysine","Oxolinic acid","Sebacic Acid","Paz-pc","Phosalone","Erucamide","Palmitoylcarnitine","Lpc(18:2)","Mellein","1-Hexadecyl-2-tridecanoyl-glycero-3-phosphoethanolamine","4-hydroxy Nonenal","GPCho(20:5/18:2)","LysoPC(20:4(5Z,8Z,11Z,14Z)/0:0)","Bis(2-ethylhexyl) adipate","LysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)","Pc(16:1(9z)/14:0)","Pc(22:5(4z,7z,10z,13z,16z)/p-18:1(9z))","(3alphaOH,20S,24S)-3,19:20,24-Diepoxydammarane-3,25-diol","Peimisine","PA(8:0/i-13:0)","Pc(o-16:0/18:2(9z,12z))","Heptadecasphinganine","1-o-hexadecyl-sn-glycero-3-phosphocholine","Pe(p-16:0/22:6)","4-Methylhexanoylcarnitine","Hexadecanamide","Ansamitocin P-3","5-nitro-2-phenylpropylaminobenzoic acid [nppb]","2-aminoindan-2-carboxylic acid","Lpc(18:1)","Prenalterol","DG(18:1(12Z)-O(9S,10R)/0:0/a-15:0)","Tris(1-chloro-2-propyl) phosphate","Pa(8:0/13:0)","Dihydrothymine","Alpha-Terpineol propanoate","Dg(20:4(8z,11z,14z,17z)-2oh(5s,6r)/0:0/18:0)","Pe(p-18:0/0:0)","L-proline","LysoPC(22:5(7Z,10Z,13Z,16Z,19Z)/0:0)","Piperidine","Perillic acid","5alpha-Pregnane-3alpha,20alpha-diol","4-Chloro-L-phenylalanine","Avocadene","Toluene","N-Acetyl-b-glucosaminylamine","Aminopentol","1-o-palmitoyl-2-o-acetyl-sn-glycero-3-phosphorylcholine","Trimethylamine N-Oxide","Acebutolol","Arachidoyl ethanolamide","Methyl 2-amino-3-(4-chlorophenyl)propanoate","Phosphocholine","Isoleucyl-thiazolidine","Ile leu","Cyclohexanecarboxylic acid","1,2-Dihydronaphthalene","Dg(15:0/18:3(9z,12z,15z)/0:0)","Phenethylamine glucuronide","Vitamin e","Acetolein","Glycodeoxycholic acid","2,3,4,5-Tetrahydro-2-pyridinecarboxylic acid","PE-NMe2(18:4(6Z,9Z,12Z,15Z)/20:2(11Z,14Z))","PE-NMe2(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","Tuberoside","3,4,5-Trimethoxycinnamic Acid","Lac Dye","Prostaglandin F1a","SM(d18:2(4E,14Z)/16:0)"],"additional_accession":[]},"is_claimable":false,"name":"Composite polyphenols mitigate microplastic exposure-related immune disturbances: a two-phase population trial","description":"As people are being widely exposed to microplastics (MPs), it is urgent to elucidate their toxicity mechanisms and identify intervention strategies to mitigate their adverse effects. This study firstly designed a two-phase population trial, comprising a pilot population (n = 151) to investigate the MP toxicity mechanisms and a 28-day randomized, double-blind, placebo-controlled trial (n = 98) evaluating the effects of an intervention with composite polyphenols (CP). By integrating a multi-omics approach with phenotype, this study found that MPs could affect specific inflammation and lipid indicators. The underlying mechanism was related to downregulated phosphatidylcholine (PC) 22:5/0:0 and stearidonic acid caused by gut microbiota disruption. CP intervention could mitigate the increase in pro-inflammatory indicators associated with high MP exposure by modulating gut microbiota and up-regulating the glycerophospholipid metabolism and arginine biosynthesis pathways. The gut microorganism Sutterella and plasma metabolite PC (22:5/0:0) may serve as potential targets for this protective action.
","dates":{"publication":"2026-08-01","submission":"2025-08-15"},"accession":"MTBLS12863","cross_references":{"HMDB":["HMDB0304943","HMDB0304933","HMDB0304928","HMDB0304927","HMDB0304924","HMDB0304923","HMDB0304919","HMDB0304915","HMDB0304914","HMDB0304225","HMDB0304199","HMDB0304195","HMDB0304128","HMDB0304037","HMDB0304033","HMDB0303940","HMDB0303698","HMDB0303499","HMDB0303382","HMDB0303125","HMDB0303085","HMDB0302983","HMDB0302980","HMDB0302916","HMDB0302897","HMDB0302841","HMDB0302828","HMDB0302259","HMDB0301794","HMDB0301792","HMDB0301751","HMDB0299052","HMDB0298693","HMDB0297659","HMDB0297356","HMDB0297313","HMDB0297306","HMDB0297046","HMDB0294929","HMDB0294918","HMDB0283860","HMDB0283850","HMDB0283746","HMDB0283732","HMDB0266642","HMDB0266104","HMDB0261964","HMDB0261877","HMDB0261861","HMDB0261860","HMDB0261823","HMDB0260409","HMDB0260228","HMDB0260189","HMDB0260130","HMDB0259627","HMDB0259541","HMDB0259481","HMDB0259285","HMDB0258954","HMDB0258881","HMDB0258406","HMDB0258298","HMDB0258110","HMDB0257989","HMDB0257951","HMDB0257787","HMDB0257364","HMDB0257354;LMPK13040018","HMDB0257308","HMDB0257158","HMDB0256240","HMDB0256157","HMDB0255448","HMDB0255420","HMDB0255383","HMDB0255369","HMDB0255165","HMDB0255104","HMDB0255084","HMDB0254445","HMDB0254402","HMDB0254205","HMDB0253899","HMDB0253021","HMDB0252541","HMDB0252508","HMDB0252267","HMDB0252265","HMDB0252230","HMDB0252227","HMDB0251787","HMDB0251690","HMDB0251673","HMDB0251568","HMDB0251280","HMDB0250941","HMDB0250542","HMDB0250518","HMDB0250469","HMDB0250272","HMDB0250146","HMDB0250087","HMDB0249592","HMDB0249518","HMDB0249359","HMDB0249004","HMDB0248866","HMDB0248763","HMDB0248497","HMDB0248390","HMDB0248168","HMDB0247961","HMDB0247904","HMDB0247862","HMDB0247839","HMDB0247666","HMDB0247652","HMDB0247617","HMDB0247525","HMDB0247471","HMDB0247454","HMDB0247382","HMDB0247360","HMDB0247359","HMDB0247308","HMDB0247056","HMDB0247015","HMDB0246889","HMDB0246783","HMDB0246665","HMDB0246555","HMDB0246118","HMDB0245946","HMDB0245691","HMDB0245288","HMDB0245271","HMDB0245221","HMDB0245146","HMDB0245031","HMDB0244895","HMDB0244522","HMDB0244521","HMDB0244272","HMDB0244264","HMDB0243883","HMDB0243712","HMDB0243571","HMDB0242596","HMDB0242371","HMDB0242339","HMDB0242182","HMDB0242168","HMDB0242164","HMDB0242162","HMDB0242155","HMDB0242146","HMDB0242125","HMDB0242004","HMDB0241951","HMDB0241673","HMDB0240616","HMDB0240608","HMDB0240598","HMDB0240261","HMDB0240219","HMDB0125163","HMDB0124975","HMDB0114355","HMDB0114070","HMDB0112341","HMDB0112327","HMDB0112128","HMDB0112127","HMDB0112083","HMDB0092919","HMDB0092913","HMDB0092909","HMDB0062775","HMDB0062720","HMDB0062551","HMDB0062534","HMDB0062432","HMDB0062410","HMDB0062399","HMDB0062364","HMDB0062359","HMDB0062207","HMDB0062121","HMDB0061699","HMDB0061694","HMDB0061693","HMDB0061690","HMDB0061657","HMDB0061649","HMDB0061643","HMDB0061164","HMDB0061135","HMDB0061034","HMDB0060897","HMDB0060829","HMDB0060793","HMDB0060712","HMDB0060436","HMDB0060410","HMDB0060393","HMDB0060385","HMDB0060118","HMDB0060015","HMDB0060013","HMDB0060006","HMDB0060004","HMDB0059980","HMDB0059978","HMDB0059933","HMDB0059915","HMDB0059633","HMDB0059601","HMDB0056004","HMDB0041939","HMDB0041893","HMDB0041611","HMDB0041527","HMDB0041287","HMDB0041023","HMDB0039971","HMDB0039883","HMDB0039536","HMDB0039443","HMDB0039439","HMDB0039340","HMDB0039212","HMDB0039051","HMDB0038786","HMDB0038736","HMDB0038660","HMDB0038568","HMDB0038499","HMDB0038380","HMDB0038244","HMDB0038197","HMDB0038196","HMDB0038149","HMDB0038120","HMDB0037906","HMDB0037021","HMDB0036838","HMDB0036836","HMDB0036822","HMDB0036791","HMDB0036768","HMDB0036664","HMDB0036651","HMDB0036630","HMDB0036583;LMFA02020010","HMDB0036579","HMDB0036461","HMDB0036172","HMDB0036064","HMDB0035803","HMDB0035689","HMDB0035512","HMDB0035473","HMDB0035215","HMDB0034941","HMDB0034757","HMDB0034696","HMDB0034648","HMDB0034525","HMDB0034505","HMDB0034436","HMDB0034423","HMDB0034299","HMDB0034297","HMDB0034293","HMDB0034081","HMDB0034079","HMDB0033724","HMDB0033601","HMDB0033397","HMDB0032705","HMDB0032662","HMDB0032613","HMDB0032590","HMDB0032354","HMDB0032306","HMDB0032093","HMDB0031897","HMDB0031661","HMDB0031609","HMDB0031469;HMDB0246912","HMDB0031210","HMDB0031031","HMDB0030993","HMDB0030990","HMDB0030830","HMDB0030801","HMDB0030666","HMDB0030524","HMDB0030396","HMDB0030048","HMDB0030039","HMDB0030016","HMDB0030014","HMDB0029949","HMDB0029804","HMDB0029683","HMDB0029635","HMDB0029607","HMDB0029156","HMDB0028882","HMDB0028848","HMDB0028832","HMDB0028828","HMDB0015281","HMDB0015014","HMDB0014766","HMDB0013997","HMDB0013407","HMDB0013247","HMDB0013070","HMDB0012799","HMDB0012710","HMDB0012555","HMDB0012517","HMDB0012515","HMDB0012454","HMDB0012219","HMDB0012210","HMDB0012152","HMDB0012108","HMDB0012100","HMDB0011756","HMDB0011751","HMDB0011719","HMDB0011687","HMDB0011686","HMDB0011640","HMDB0011635","HMDB0011627","HMDB0011523","HMDB0011517","HMDB0011477","HMDB0011475","HMDB0011352","HMDB0011343",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