Metabolites were identified by matching experimental mass spectra and retention times against databases including HMDB, Metlin, and the Majorbio Database. Differential metabolites were screened using criteria of variable importance in projection (VIP) > 1 and p < 0.05, followed by KEGG pathway enrichment analysis to elucidate metabolic pathway alterations.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - negative - reverse phase","Liquid Chromatography MS - positive - reverse phase"],"chromatography_protocol":["Chromatographic separation was performed on a Thermo UHPLC system equipped with an ACQUITY HSS T3 column. Mobile phase B (acetonitrile:isopropanol:water = 47.5:47.5:5, v/v/v) was used with gradient elution programs optimized for positive and negative ion modes, ensuring efficient separation of metabolites.
"],"publication":["Decoding the Regulatory Networks of Proteus mirabilis Under Succinic Acid Stress: A Multi-Omics Approach."],"submitter_affiliation":["Peking University"],"submitter_name":["Duo Keai"],"organism_part":["Cell culture"],"technology_type":["mass spectrometry"],"disease":[""],"extraction_protocol":["Each 50 mg aliquot was mixed with an extraction solution (methanol:water = 4:1, containing 0.02 mg/mL L-2-chlorophenylalanine as an internal standard), then processed via frozen grinding (Wonbio-96c) and low-temperature ultrasonication.
"],"organism":["Proteus mirabilis"],"data_transformation_protocol":["Raw mass spectrometry data were preprocessed using Progenesis QI to generate CSV matrices of metabolite features. These matrices were filtered (requiring detection in 80% of samples per group), imputed for missing values, sum-normalized, and uploaded to the Majorbio cloud platform for multivariate analyses including principal component analysis (PCA) and orthogonal partial least squares-discriminant analysis (OPLS-DA).
"],"study_factor":["Group"],"metabolights_link":["https://www.ebi.ac.uk/metabolights/MTBLS12952"],"submitter_email":["keaiduoduo998@126.com"],"sample_collection_protocol":["Single colonies of Proteus mirabilis from Tryptic Soy Agar (TSA) plates were inoculated into Tryptic Soy Broth (TSB), incubated overnight at 37°C, centrifuged, resuspended to OD 550 =0.1, then treatment groups were mixed with MIC-level succinic acid (1:1 volumetric ratio) and control groups with sterile triple-distilled water, incubated at 37°C for 24 h, and finally centrifuged to collect pellets stored at -80°C.
"],"omics_type":["Metabolomics"],"study_design":["Biofilm formation","Succinic acid","Proteus mirabilis","Multi-omics"],"curator_keywords":["Biofilm formation","Succinic acid","Proteus mirabilis","Multi-omics"],"mass_spectrometry_protocol":["Mass spectrometric analysis was conducted on a Q Exactive HF-X spectrometer with an ESI source operating in data-dependent acquisition (DDA) mode. Full MS scans were acquired at a resolution of 60,000, and MS/MS scans at 7,500, with ion-spray voltage and collision energy optimized for metabolite detection.
"],"metabolite_name":["Phorbol-12,13-dibutyrate","Laninamivir","(3R,4S)-3,4,5-trihydroxy-3,4-dihydro-2H-naphthalen-1-one","Uridine Monophosphate","Ile-Thr-Asn","gamma-Glu-Ser","Pe(18:1/0:0)","Phe-Ile","Tyr-Tyr-Leu","C75 trans","N1,N10-Dicoumaroylspermidine","Imidazolelactic acid","MPPa (Methyl pyropheophorbide-a)","Val-Met","2-phosphoglyceric acid","Asp-Gln-Leu","Hexanoylglycine","3-O-Demethylfortimicin A","Phenazepam","Trans-4-Hydroxycyclohexylacetic acid","Coumatetralyl","1,2,3,4,5,6-Hexahydro-5-(1-hydroxyethylidene)-7H-cyclopenta[b]pyridin-7-one","PEtOH(15:0/17:1)","Thr-Pro-Lys","N-Formyl-met-leu-phe-lys","L-Prolinamide, 5-oxo-L-prolyl-L-norvalyl-","Evogliptin","Cyclohexa-1,3-diene-1,2-dicarboxylic acid","Gly-Gly-Leu","Flavin mononucleotide","Gly-Glu","L-Monomenthyl glutarate","Myristyl sulfate","Glu-Lys-Thr","GPEtn(17:1/16:0)","3-Hydroxyanthranilic acid","Pe(o-13:1/4:0)","Apstatin","Gly-Pro-Arg","Flumioxazin","Bis(N-pantothenylamidoethyl) disulfide","Gly-Pro-Arg-Pro","Psychosine sulfate","Asp-Asn-Ile","Indole-3-acetylglutamic acid","N-Acetyl-DL-Valine","2',3,4',5-Tetrahydroxy-4-prenylstilbene","3',5'-Cyclic GMP","Ala-Ala-Gly","11-beta-Hydroxyandrosterone-3-glucuronide","Tyr-Val-Gly","Alpha-cyano-3-hydroxycinnamic acid","Sarmentosin","Phosphoenol pyruvate","Lisinopril-tryptophan","Licoricesaponin F3","Asn-Asp-Leu","Kapporphin","Hyp-Pro","Pro-Gln","Glu-Asp-Leu","7-Benzylidenenaltrexone","Oleyl sarcosine","Clocapramine","Pseudouridine","Gly-Thr-Ile","Caffeic acid","Met-Glu","PA(6 keto-PGF1alpha/10:0)","Ent-6R,16bOH,17-Trihydroxy-7-oxo-6,7-seco-19,6-kauranolide 6-O-glucoside","Tetrahydroaldosterone-3-glucuronide","Ochromycinone","Linatine","2,4-dihydroxybutanoic acid","Cyclokievitone","Apigenin 7-o-glucoside","Pro-Glu","Val-Gly-Ile","(-)-Pinoresinol","Pg(16:0/17:1)","Cinncassiol D2 glucoside","Linalool oxide D 3-[apiosyl-(1->6)-glucoside]","Gln-Pro","Yohimbine","Dihydrofoliamenthic acid","Petasitenine","Guanosine","Phe-Gln","Neoandrographolide","Cytosine arabinoside monophosphate","Propyl propane thiosulfonate","Moxifloxacin","Dodecyl Hydrogen Sulfate","Glu-Trp-Ile","Carboxyfentanyl","Pro-Gly-Ser","(S)-Tetrahydrocolumbamine","O-Cresol","Morph","Sulfadoxine","Leu-Ser-Tyr","Linagliptin","Glyceric acid","Pro-His","Hexadecanedioic acid","Pe(34:1)","Phthalic acid","(S)-3-Hydroxyisobutyric acid","Gly-Gln-Ile","N6-Acetyl-5S-hydroxy-L-lysine","Gly-Leu-Ser","2-octylpent-2-enedioic acid","Dihydrobenzofuran","Ile-Gln","Amphibine H","Isorhynchophylline","Lnape(16:1/n-16:1)","Annomuricatin A","Ala-Ala","Pyrophosphate","Uridine","Lpe(19:1)","Malonic acid","Asn-Val","Implitapide","Lysosulfatide","Tyr-Gln","Isopentenyladenine","Histidylarginine","Isocitric acid","D-Ribose-1-phosphate","Thr-Ala","Silmitasertib","4-dodecylbenzenesulfonic acid","CDP-DG(PGF1alpha/i-12:0)","Coumaryl acetate","Citronellyl acetate","Adenosine monophosphate","Uric acid","NAD","Glu-Glu-Leu","Glu-Thr-Leu","Fumaric acid","Lys-Tyr-Tyr","Cis-3-hexen-1-ol","Ipamorelin","Dslet","Glu-Trp","2-Octenedioic acid","Arphamenine B","L-Phosphoarginine","Sulfo jasmonate","Phenylpyruvic acid","N-alpha-acetyllysine","N-acetyl-l-methionine","Sagopilone","Tetradecanedioic acid","Traumatic acid","Udp-n-acetylmuraminate","DAF-2","5-(hydroxymethyl)-3-(1-hydroxy-8-methylnonyl)oxolan-2-one","4-(Glutamylamino) butanoate","Pectenotoxin 2","Modecainide","Dibekacin","Integerrimine","Trp-Gln","4-{[3-(diethylamino)propyl]amino}-4-oxobut-2-enoic acid","Senkyunolide N","6-Methoxymellein","Pe(12:0/0:0)","S-(9-hydroxy-PGA1)-glutathione","Phalloidine","Ala-Val-Ala","gamma-Glu-Hyp","Isovalerylurea","Deoxynivalenol","10-Hydroxy-2-decenoic acid","(+)-Dehydrovomifoliol","Mono(2-ethyl-5-oxohexyl)phthalate","Ligusticide","gamma-Glu-Phe","N(G)-Nitroarginine-4-nitroanilide","Trans-3-Octenedioic acid","Cholylasparagine","Monoisobutylphthalic Acid","Neuromedin B (4-10)","Melibiitol","1-Carboxycyclohexaneacetic Acid","Sweroside","Asp-Met","Iclaprim","Bms-275183","Succinic anhydride","Suberic acid","5,8,11-trihydroxyoctadec-9-enoic acid","L-Threonic acid","2-amino-6-chloropurine","Ala-Glu-Leu","Norophthalmic acid","N-Desmethyl Topotecan","Pyro(l-alpha-aminoadipyl)-L-histidyl-L-thiazolidine-4-carboxamide","Moreollin","Ixabepilone","1-(2,2-dimethylpropanoyl)pyrrolidine-2-carboxylic acid","2,3-dihydroxyundecanedioic acid","H-D-Val-Leu-Lys-pNA","1-heptadecanoyl-glycero-3-phosphate","5-(2-Methylpropyl)-3,6-dioxo-2-piperazinepropanoic acid","Cyclo(Trp-Asp-Pro-Ile-Leu)","Carcinine","N-lauroylsarcosine","Glu-Val","Xanthosine","Pisumoside A","Butanedioic acid, octenyl-","Aristospan","Melledonal A","Citric acid","Adenosine 2'-phosphate","Norgestrel","Latrunculin B","Juzirine","2-Aminoheptanedioic Acid","Val-Asn","Val-Asp","6-Phosphogluconic Acid","Fipronil","Cis-Zeatin O-glucoside","Calophymembranside B","3-Oxovalproic acid","Alpha-d-glucose","4-hydroxyphenylacetic acid","Serdexmethylphenidate","4-amino-n'-hydroxypyrimidine-5-carboximidamide","beta-Ala-His","2-{[(4-methyl-2-oxo-2h-chromen-7-yl)amino]carbonyl}benzoic acid","N6-(Delta2-Isopentenyl)-adenine","Ilepatril","Leu-Gly-Gly","Dihydroergocornine","Glucose 6-phosphate","Hygromycin B","(+/-)-3-Hydroxybutyric acid","8-Hydroxyadenine","Zymonic acid","Fa(18:2+3o)","Flavin adenine dinucleotide","1-Octen-3-yl primeveroside","Ile-Val","Velagliflozin","2-Hydroxycaproic acid","Cinnamoylglycine","Mesaconitine","Lpe(o-6:0)","3alpha-Hydroxyoreadone","2-hydroxy-3-(5-methoxycarbonylcyclohexa-2,4-dien-1-yl)propanoic acid","Leucinic Acid","Asp-Phe","Gln-Val-Ala","Oxyacanthine","Elaterinide","Dhesn","Tyr-Thr-Gly-Phe-Leu-Thr","2-Keto-4-methylthiobutyric acid","Asp-Phe-Gln","Mesobilirubinogen","Americine","5-(4-sulfophenyl)undecane","L-malic acid","Glabrin D","2,2',4,4'-Tetrachlorobiphenyl","Ethenodeoxyadenosine","Mauritine A","Gly-Thr","7,3',4'-Trihydroxyflavone","3-hydroxymandelic acid","6S,9R-Dihydroxy-4,7E-megastigmadien-3-one 9-[apiosyl-(1->6)-glucoside]","Cefapime","2-(3-(2-Aminoethyl)-1h-indol-5-yloxy)acetyl-l-tyrosyl-glycinamide","Endomorphin-2","Glycosides","Pirmenol","Met-Hyp","3-Methyl-2-Oxovaleric Acid","Gln-gamma-Glu","PDE-4 Inhibitors","4-Butyl-5-hydroxy-2-(4-hydroxyphenyl)-1-phenyl-1H-pyrazol-3(2H)-one","5-Hydroxyhexyl glucoside","Histidinohydroxylysinonorleucine","4-Methyl-5-oxo-2-pentyl-2,5-dihydro-3-furancarboxylic acid","Lixivaptan","Guanosine 5'-monophosphate","Glycerol 3-Phosphate","Y-Morphine","Val-Pro-Gly-Val-Gly","Neoacrimarine K","4-hydroxyphenylpyruvic acid","Gln-Ala-Leu","3-furoic acid","Pinonic acid","Ttatpn","Ethyl myristate","Phe-Pro-Arg","Rubiadin","9-(2,3-dihydroxypropoxy)-9-oxononanoic acid","Gly-Glu-Leu","Ile-Asp","Pe(16:1/0:0)","Phe-Ala-Asp","2-methoxybenzoic acid","Pe(17:1/18:1)","Pro-Leu","Citramalic Acid","L-Threonine","Tridecanedioic acid","3-guanidinopropionic acid","8-Amino-7-oxononanoic acid","beta-Alanine","Netilmicin","Gliadins","Methyl glucosinolate","Dimerum acid","Dihydroouabain","Vinblastine","Epidihydrophaseic acid","Gly-Leu","(Z)-3-hydroxydodec-5-enoic acid","10-hydroxydecanoic acid","Asp-Gly-Leu","Imazapic","DL-4-Hydroxyphenyllactic Acid","NeuAc(alpha->6)GalNAc(alpha1->O)Ser","Preladenant","S-(PGA1)-glutathione","Phloionolic acid","S-Prenyl-L-cysteine","Loperamide","4-Methylbenzoic Acid","Lansamide 4","3-amino-3-(4-chlorophenyl)propanoic acid","Met-Thr-Leu","Valeryl 4-hydroxy valsartan","Lpe(o-5:0)","Gly-Val-Leu","Asp-Leu-Ser","Met-gamma-Glu","Asn-Ala","Lpe(16:1)","Dichloroisoproterenol","Diphenhydramine N-glucuronide","Phosphate","D-Phenyllactic acid","2-acetylaminofluorene","Capsianoside V","(15a,20R)-Dihydroxypregn-4-en-3-one 20-[glucosyl-(1->4)-6-acetyl-glucoside]","Amygdalin","Dihydrocoumarin","Isopropylmaleic acid","2-Propyl-2,4-pentadienoic acid","Nonactinic acid","Thymidine 5'-monophosphate","Cornoside","Lpe(16:0)","Protodioscin","Ala-Ala-Leu","2-Hydroxysebacic acid","Gly-Thr-Ala","Fosteabine","Aureomycin","Glu-Glu","7-Epi-12-hydroxyjasmonic acid","Ala-Ile","Aminocaproic acid","Glu-Asp-Lys","5-methoxysalicylic acid sulfate","Ophthalmic Acid","Nicotinamide-adenine-dinucleotide phosphate","L-Glutamic Acid","Sarecycline","Xi-Linalool 3-[rhamnosyl-(1->6)-glucoside]","N-(3-acetamidopropyl)pyrrolidin-2-one","PGP(5-iso PGF2VI/20:3(8Z,11Z,14Z))","Leu-Pro-Glu","17-aag","Indoleacrylic acid","Xanthosine 5'-monophosphate","Etiocholanolone glucuronide","Lpe(14:1)","Glu-Gly-Ile","Gly-Arg-Gly-Asp-Ser-Pro","Sisomicin sulfate","Phe-Phe-Thr","Pro-Lys-Ser","Pro-Hyp","Lnape(17:1/n-17:0)","Carvedilol","Succinic acid","Endalin","NPC","Beta-Funaltrexamine","7,3'-dihydroxyflavone","Daidzein-4'-glucoside","N-Docosahexaenoyl Glycine","Hippuric acid","Adenosine 5'-diphosphate","Ethyl 3-cyano-6-methyl-2-(phenylthio)isonicotinate","Tyr-Gly-Gly","Carboxymethyl chitosan","3-hydroxyphenylacetic acid","Myelopeptides","Spongouridin","UDP-D-Galactose","N,n-dimethyl-histidine","2-hydroxy-3,4-dimethoxybenzoic acid","Asn-Asp-Ile","(2S)-2-Amino-6-[(3-formylpiperidin-1-yl)amino]hexanoic acid","4-(decan-4-yl)benzenesulfonic acid","Lpe(15:0)","Arg-His-Phe-Trp-Gln-Gln","Damme","Sulfametrole","Senecionine N-oxide","Pantolactone","Emorfazone","2-Methylhippuric acid","Lys-Asp-Thr","7-Hydroxy-6-methyl-8-ribityl lumazine","(E)-3-Hydroxy Tamoxifen O-|A-D-Glucuronide","N-acetyl-l-tyrosine","4-Aminosalicylic acid","Blumenol C O-[rhamnosyl-(1->6)-glucoside]","Echothiophate","N-Acetyl-1-methylhistidine","Tyr-Lys-Ser","(3R)-Beta-Leucine","Inosine","2-mercaptobenzothiazole","GPEtn(16:1/16:0)","Pe(14:0/17:1)","Gly-Ser-Ala","Ile-Hyp","N-Acetyl-L-phenylalanine","3-(2-hydroxybutan-2-yl)-5-oxooxolane-3-carboxylic acid","Palmitic acid","Protocatechuic acid","5-(4-Tert-butylphenyl)-1,3,4-oxadiazole-2-thiol","5-Aminovaleric Acid","Ala-Glu","Ala-Gly-Leu","2-[3-(sulfooxy)phenyl]acetic acid","Ser-Phe","4-ethylamino-6-isopropylamino-1,3,5-triazin-2-ol","Leu-Pro-Pro","Cholylglutamic acid","Lpe(18:1)","Gly-Asp-Leu","3-methoxyphenylacetic acid","Cucurbitacin A","6-hydroxy-2-aminopurine","Leu-Arg-Asn-Arg","Ser-Gly-Leu","(S)-3-Hydroxy-N-methylcoclaurine","Ile-Glu-Thr-Asp-fluoromethyl ketone","2-(1-hydroxyethyl)-4-(2-hydroxypropyl)-2h-furan-5-one","Soyasaponin I","6-Phenyltetrazolo[1,5-b]pyridazin-7-ol","Glu-Gly-Leu","Gluten exorphin A5","3-Dehydroshikimic acid","Val-Pro-Leu","Cd 1790","Neobignonoside","Cyclic adp-ribose","Dienogest","Fucose","2-Hydroxy-4-[(1R)-1-hydroxy-8-methyl-6-oxononyl]-3-methyl-2H-furan-5-one","1-methylhydantoin","4-(4-Methylcyclohexyl)-4-oxobutanoic acid","(Z)-2-oct-7-enylpent-2-enedioic acid","Glu-Leu-Ser","Avenalumin III","Thr-Leu","Melanostatin","PA(5-iso PGF2VI/12:0)","Asn-Phe-Ser","Dynasore","Apigenin","(2R,4S)-1-(Tert-butoxycarbonyl)-4-phenylpyrrolidine-2-carboxylic acid","Corynantheine","Microcystin LW","PS(5-iso PGF2VI/14:0)","Pe(14:0/16:1)","Cryptolepine","2-Methylguanosine","N-Acetylhistidine","(S)-Reticuline","Dodecanedioic acid","Gly-Pro-Hyp","9'-Carboxy-gamma-chromanol","L-Glutamine","Deoxyguanosine","Norerythromycin","Pe(16:1/17:1)","Omadacycline","Monotropein","S-(PGJ2)-glutathione","Pe(14:0/16:0)","Bromocriptine","Cyclosquamosin F","Thymidine","Gly-Glu-Ile","Glu-Tyr-Asp-Lys","5-Chloro-2'-deoxyuridine","Tetrapeptide","N-acetylornithine","3-Hydroxysebacic Acid","Asp-Gly-Ile","Cinnamoside","L-Aspartic Acid","2-Isopropyl-5-methylphenol acetate","2-Furoic acid","N-Acetyl-D-alloisoleucine","7-hydroxy-1,1-dimethyl-2,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylic acid","Dmg-mino","2,2'-(3-methylcyclohexane-1,1-diyl)diacetic acid","Undecanedioic acid","Lesopitron","Methyl jasmonate","Pro-Asn","3-(6-hydroxy-7-methyloctyl)-3,6-dihydro-1H-furo[3,4-c]furan-4-one","Methyl 5-(hydroxymethyl)pyrrolidine-3-carboxylate","(+/-)13-HpODE","(Z)-6-methyl-2-(4-methylpent-3-enyl)hept-2-enedioic acid","Oxypurinol","3-Ethoxypropanoic Acid","Protoporphyrin IX","Sedoheptulose","N5-Acetyl-N2-gamma-L-glutamyl-L-ornithine","Abscisic alcohol 11-glucoside","Methyl 6-O-galloyl-beta-D-glucopyranoside","P-Hydroxyhippuryl-his-leu-OH","Ser-Val-Gly-Glu","Azelaic acid","Acetyl-Ser-Asp-Lys-Pro","Leu-Ser","Casokefamide","(4E,7E)-dodeca-4,7-dienedioic acid","28-Hydroxywithanolide E","GPEtn(16:1/18:1)","Pe(16:0/19:1)","Leuphasyl","Asn-Ile-Thr-Glu","Glu-Asp-Ile","S-(11-OH-9-deoxy-delta9,12-PGD2)-glutathione","Ziprasidone","Pyro-L-glutaminyl-L-glutamine","Sedoheptulose 7-phosphate","11-(2-hydroxy-3,4-dimethyl-5-oxofuran-2-yl)undecanoic acid","(2E)-4-hydroxy-5-methyl-2-propylidene-3(2H)-furanone","Pyroglutamyl-glutamyl-proline amide","Indole-3-carboxylic acid","N-Methyl-L-glutamate","Gly-Gly-Met","Norvaline","Lpe(17:1)","(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate"],"additional_accession":[]},"is_claimable":false,"name":"Decoding the Regulatory Networks of Proteus mirabilis Under Succinic Acid Stress: A Multi-Omics Approach","description":"Proteus mirabilis, a key catheter-associated urinary tract infection pathogen that forms antibiotic-resistant crystalline biofilms, was shown via multi-omics analyses to be multimodally inhibited by succinic acid. At 15 mM, succinic acid reduced the bacterium’s growth by 70% and biofilm formation by 50%. Metabolomics revealed dysregulation in tryptophan/arginine metabolism, nucleotide biosynthesis, and the tricarboxylic acid cycle; transcriptomics showed downregulated ribosomal genes, oxidative phosphorylation, and efflux pumps plus upregulated arginine transport; and proteomics demonstrated suppressed T6SS virulence factors and iron acquisition proteins. Mechanistically, succinic acid is proposed to reduce K6 acetylation of the histone-like nucleoid structuring protein, enhancing its oligomerization to repress T6SS genes and inhibit biofilm formation. By targeting metabolism, virulence, and stress adaptation, succinic acid circumvents single-target resistance, offering a strategy to combat multidrug-resistant P. mirabilis via biofilm disruption and pathogenicity suppression.
","dates":{"publication":"2025-09-08","submission":"2025-09-08"},"accession":"MTBLS12952","cross_references":{"HMDB":["HMDB0004231;HMDB0304820","HMDB0245190","HMDB0246945","HMDB0038169;LMPR0102010005","HMDB0028951","HMDB0255358","HMDB0001414","HMDB0000450;HMDB0245508","HMDB0001432","HMDB0255374","HMDB0031659","HMDB0000033;PW_C000023","HMDB0028835","HMDB0010720","HMDB0000086","HMDB0000235;PW_C000158","HMDB0000725","HMDB0000062","HMDB0000214","HMDB0000630","HMDB0033453","HMDB0029136","HMDB0000271;PW_C000185","HMDB0000064;PW_C000046","HMDB0002172","HMDB0002064","HMDB0000446","HMDB0028864","HMDB0000070;HMDB0000716;HMDB0000070","HMDB0000132;PW_C000086","HMDB0000216","HMDB0258242","HMDB0028944","HMDB0000402","HMDB0011178","HMDB0031321","HMDB0013815","HMDB0000306;PW_C000210","HMDB0000300;PW_C000204","HMDB0000187;PW_C000120","HMDB0030776","HMDB0244899","HMDB0003464","HMDB0247457","HMDB0004620","HMDB0034198","HMDB0028702","HMDB0001044","HMDB0000157;PW_C000102","HMDB0000239;PW_C000161","HMDB0035157","HMDB0060477","HMDB0011718","HMDB0028939","HMDB0002151","HMDB0000802","HMDB0028925","HMDB0039857","HMDB0304797","HMDB0039238","HMDB0253048","HMDB0094673","HMDB0004816","HMDB0038482","HMDB0000101;PW_C000068","HMDB0029011","HMDB0030175","HMDB0029027","HMDB0028739","HMDB0041054","HMDB0028969","HMDB0036162","HMDB0248371","HMDB0029393","HMDB0002224","HMDB0028889;HMDB0253179;HMDB0028889","HMDB0000473","HMDB0032985","HMDB0244469","HMDB0030091","HMDB0256235","HMDB0253732","HMDB0029770","HMDB0031388","HMDB0258957","HMDB0259006","HMDB0030895","HMDB0253472","HMDB0259943","HMDB0029010","HMDB0002059","HMDB0062645","HMDB0034473","HMDB0011749","HMDB0012642","HMDB0253033","HMDB0038230","HMDB0028827","HMDB0033865","HMDB0303581","HMDB0028853","HMDB0029031","HMDB0029563","HMDB0014928","HMDB0301777","HMDB0011176","HMDB0252758","HMDB0028907","HMDB0000210;HMDB0250782;PW_C000136","HMDB0252941","HMDB0029134","HMDB0255348","HMDB0015503","HMDB0032175","HMDB0014906;PW_C009236","HMDB0256449","HMDB0003193","HMDB0011174","HMDB0035302","HMDB0245744","HMDB0015101;PW_C009406","HMDB0029342","HMDB0251223","HMDB0304246","HMDB0001173","HMDB0029895","HMDB0029126","HMDB0029443","HMDB0258761","HMDB0060787","HMDB0006050","HMDB0014954","HMDB0254726","HMDB0004487;HMDB0035824","HMDB0001198","HMDB0000259;PW_C000178","HMDB0013609","HMDB0252688","HMDB0251906","HMDB0033207","HMDB0246316","HMDB0250850","HMDB0041542","HMDB0244231","HMDB0033404","HMDB0033895","HMDB0253648","HMDB0041855","HMDB0002182","HMDB0033290","HMDB0257407","HMDB0244982","HMDB0256204","HMDB0281882","HMDB0039214","HMDB0029076","HMDB0034699","HMDB0028994","HMDB0038535","HMDB0254231","HMDB0282802","HMDB0000678","HMDB0030174","HMDB0253166","HMDB0256611","HMDB0028848","HMDB0304812","HMDB0013062","HMDB0257232","HMDB0037381","HMDB0255512","HMDB0000860","HMDB0005006","HMDB0279170","HMDB0029135","HMDB0252100","HMDB0028912","HMDB0039773","HMDB0002184","HMDB0244421","HMDB0002640","HMDB0292784","HMDB0028934","HMDB0028981","HMDB0059787","HMDB0252409","HMDB0014447;PW_C008836","HMDB0242528","HMDB0034327","HMDB0255508","HMDB0253565","HMDB0041137","HMDB0304811","HMDB0013016","HMDB0014344","HMDB0035620","HMDB0014380","HMDB0010715","HMDB0028773","HMDB0254828","HMDB0256241","HMDB0244703","HMDB0034130","HMDB0032066","HMDB0256561","HMDB0244221","HMDB0303682","HMDB0033492","HMDB0033242","HMDB0060336","HMDB0060818","HMDB0006344","HMDB0040135","HMDB0029001","HMDB0028823","HMDB0256777","HMDB0259661","HMDB0059792","HMDB0259710","HMDB0011756","HMDB0034276","HMDB0032782","HMDB0257571","HMDB0252101","HMDB0252352","HMDB0255461","HMDB0250751","HMDB0242753","HMDB0250242","HMDB0256789","HMDB0255168","HMDB0029156","HMDB0059851","HMDB0040216","HMDB0029388","HMDB0030201","HMDB0005772","HMDB0031342","HMDB0015468","HMDB0001924","HMDB0036059","HMDB0252196","HMDB0011179","HMDB0060742","HMDB0000197","HMDB0254723","HMDB0034450","HMDB0030465","HMDB0036317","HMDB0011177","HMDB0304808","HMDB0003217;LMPK12050218","HMDB0013302","HMDB0033988","HMDB0036103;LMFA01030784","HMDB0013892","HMDB0242418","HMDB0257214","HMDB0000763","HMDB0029737","HMDB0258435","HMDB0014501","HMDB0035063","HMDB0034121","HMDB0241333","HMDB0255320","HMDB0003447","HMDB0246635","HMDB0041421","HMDB0302622","HMDB0248191","HMDB0040844","HMDB0303365","HMDB0032797;LMFA02020001","HMDB0244751","HMDB0060706","HMDB0248564","HMDB0251473","HMDB0242032","HMDB0252568","HMDB0005781;LMPK12050104","HMDB0249635","HMDB0245493","HMDB0254678","HMDB0253467","HMDB0242031","HMDB0030346","HMDB0250918","HMDB0252807","HMDB0246557","HMDB0249264","HMDB0001932","HMDB0246739","HMDB0014520","HMDB0251406","HMDB0249851","HMDB0039534","HMDB0259955","HMDB0245396","HMDB0035601","HMDB0301782","HMDB0014621","HMDB0254562","HMDB0061155","HMDB0031483","HMDB0000560","HMDB0244390","HMDB0303844","HMDB0000209;PW_C000135","HMDB0257360","HMDB0245129","HMDB0013308","HMDB0059810","HMDB0253451","HMDB0032014","HMDB0254661","HMDB0259285","HMDB0002685","HMDB0006547;LMFA01030357;PW_C002804","HMDB0040824","HMDB0036015","HMDB0254042","HMDB0002214","HMDB0030471","HMDB0256579","HMDB0039090","HMDB0241954","HMDB0245914","HMDB0255988","HMDB0011564","HMDB0243685","HMDB0285309","HMDB0288521","HMDB0251572","HMDB0002117;LMFA08010004","HMDB0038026","HMDB0061691","HMDB0003148","HMDB0031830","HMDB0257752","HMDB0032538","HMDB0036141","HMDB0040210","HMDB0004362;LMFA06000051","HMDB0000792;LMFA01170006","HMDB0040276","HMDB0032231","HMDB0039022","HMDB0032972","HMDB0032323","HMDB0008953","HMDB0250583","HMDB0008924","HMDB0008889;LMGP02010106;PW_C004937","HMDB0014453","HMDB0008843","HMDB0244203","HMDB0031581","HMDB0004437","HMDB0003229","HMDB0013864","HMDB0248993","HMDB0061888","HMDB0032147","HMDB0006331;LMFA01170077","HMDB0000207;LMFA01030002","HMDB0257053","HMDB0034244","HMDB0256055","HMDB0259918","HMDB0035689","HMDB0248463","HMDB0000162;PW_C000106","HMDB0001494;PW_C001151","HMDB0246355","HMDB0256664","HMDB0252848","HMDB0029598","HMDB0253219","HMDB0254895","HMDB0244944","HMDB0000097;PW_C000065","HMDB0304601","HMDB0246239","HMDB0037562","HMDB0008893","HMDB0008959","HMDB0256752","HMDB0008957","HMDB0061887","HMDB0245025","HMDB0041220","HMDB0031195","HMDB0244517","HMDB0061665","HMDB0038349","HMDB0029586","HMDB0000772","HMDB0012273;LMFA08010009","HMDB0241946","HMDB0013078","HMDB0002100","HMDB0002088","HMDB0242096","HMDB0303184","HMDB0249644","HMDB0012252","HMDB0241990","HMDB0001320","HMDB0037789","HMDB0245878","HMDB0259275","HMDB0001388;LMFA01030152;PW_C001073","HMDB0245012","HMDB0032358;LMFA08040058","HMDB0040615","HMDB0001104","HMDB0032370","HMDB0249169","HMDB0012215","HMDB0256048","HMDB0041044","HMDB0257928","HMDB0036998","HMDB0030897","HMDB0302335","HMDB0244166","HMDB0059602","HMDB0246518","HMDB0302963","HMDB0013658","HMDB0039937","HMDB0302880","HMDB0258433","HMDB0029638;HMDB0303310","HMDB0034171","HMDB0000005","HMDB0036565","HMDB0036683","HMDB0062656","HMDB0247738","HMDB0040778","HMDB0030759","HMDB0002302","HMDB0250809","HMDB0035934","HMDB0245222","HMDB0015137","HMDB0256016","HMDB0258163","HMDB0037013","HMDB0029876","HMDB0258481","HMDB0003312;LMPK12050038","HMDB0060484","HMDB0252534","HMDB0000806","HMDB0249107","HMDB0242027","HMDB0254080","HMDB0062225","HMDB0248180","HMDB0035872","HMDB0249068","HMDB0001107","HMDB0259352","HMDB0013938","HMDB0014736;PW_C009087","HMDB0302428","HMDB0011654","HMDB0243964","HMDB0254199","HMDB0255222","HMDB0254453","HMDB0014888","HMDB0014339","HMDB0241792","HMDB0257169","HMDB0015339","HMDB0257856","HMDB0030205","HMDB0014514","HMDB0000671","HMDB0252830","HMDB0255839","HMDB0255871","HMDB0029091","HMDB0255056","HMDB0028694","HMDB0257166","HMDB0029771","HMDB0029519","HMDB0242088","HMDB0303832","HMDB0041819","HMDB0240687","HMDB0062407","HMDB0247435","HMDB0247924","HMDB0014784","HMDB0302058","HMDB0000303","HMDB0014903","HMDB0255882","HMDB0246302","HMDB0247832","HMDB0030200","HMDB0029087","HMDB0033573","HMDB0060525","HMDB0033991;HMDB0247842;LMPK12050013","HMDB0242382","HMDB0028918","HMDB0256731","HMDB0246456","HMDB0254707","HMDB0029005","HMDB0013924","HMDB0034927","HMDB0253757","HMDB0252687","HMDB0032711","HMDB0062478","HMDB0302594","HMDB0242212","HMDB0303713","HMDB0251891","HMDB0000030","HMDB0014632;PW_C008993","HMDB0000244;HMDB0247501;PW_C000165","HMDB0013055","HMDB0259346","HMDB0303982","HMDB0254263","HMDB0029022","HMDB0257843","HMDB0029023","HMDB0028913","HMDB0256563","HMDB0251933","HMDB0250332","HMDB0033115","HMDB0040551","HMDB0030421","HMDB0304492","HMDB0296914","HMDB0040655","HMDB0029030","HMDB0015197;PW_C009493","HMDB0029028","HMDB0011175","HMDB0002579","HMDB0255692","HMDB0248243","HMDB0030461","HMDB0034552","HMDB0028933","HMDB0000468","HMDB0011738","HMDB0014822","HMDB0304796","HMDB0030116","HMDB0015307","HMDB0000929;PW_C000741","HMDB0250822","HMDB0034362","HMDB0033427","HMDB0251067","HMDB0004096;PW_C002060","HMDB0006465","HMDB0251874","HMDB0060683","HMDB0250718","HMDB0028757","HMDB0247576","HMDB0035309","HMDB0242744","HMDB0000738","HMDB0094651","HMDB0060494","HMDB0041802","HMDB0245897","HMDB0000734","HMDB0259023","HMDB0005773","HMDB0028941","HMDB0028756","HMDB0015116","HMDB0015378","HMDB0001894","HMDB0014964","HMDB0034520","HMDB0303466","HMDB0014935","HMDB0041423","HMDB0254911","HMDB0256256","HMDB0254743","HMDB0005796","HMDB0011166","HMDB0041886","HMDB0011180","HMDB0029739","HMDB0028902","HMDB0013021","HMDB0029042","HMDB0028989","HMDB0255464","HMDB0303186","HMDB0028712","HMDB0039661","HMDB0257310","HMDB0255658","HMDB0304810","HMDB0094711","HMDB0029581;LMFA01030100","HMDB0012275","HMDB0029000","HMDB0013058","HMDB0028954","HMDB0028995","HMDB0259093","HMDB0003331","HMDB0257038","HMDB0244794","HMDB0000159;PW_C000104","HMDB0000262;HMDB0010337;HMDB0000262;PW_C000179","HMDB0254035","HMDB0256341","HMDB0252691","HMDB0030285","HMDB0034518","HMDB0242598","HMDB0060493","HMDB0031139","HMDB0038233","HMDB0259345","HMDB0252911","HMDB0033348","HMDB0029113","HMDB0029069","HMDB0303680","HMDB0060533","HMDB0251507","HMDB0014700","HMDB0000058","HMDB0246429","HMDB0028988","HMDB0247190","HMDB0252876","HMDB0004044","HMDB0028982","HMDB0000759","HMDB0000292","HMDB0039348","HMDB0029368","HMDB0035603","HMDB0012201","HMDB0028906","HMDB0015078","HMDB0060679","HMDB0000403","HMDB0003581","HMDB0252678","HMDB0253034","HMDB0028922","HMDB0000050;HMDB0247583;PW_C000034","HMDB0028959","HMDB0015217","HMDB0028695","HMDB0015171","HMDB0028917","HMDB0000452","HMDB0240650","HMDB0003282","HMDB0003540","HMDB0033910","HMDB0034168","HMDB0004825","HMDB0000158;PW_C000103","HMDB0000172;PW_C000112","HMDB0250630","HMDB0256598","HMDB0000902","HMDB0029052","HMDB0029075","HMDB0000897","HMDB0061918;HMDB0244886","HMDB0015333","HMDB0000072;PW_C000051","HMDB0012156","HMDB0000696;PW_C000548","HMDB0002243","HMDB0000060;LMFA01060003;PW_C000042","HMDB0002432","HMDB0244974","HMDB0257624","HMDB0002271","HMDB0240493","HMDB0028854","HMDB0029884","HMDB0015654","HMDB0245137","HMDB0000034;PW_C000024","HMDB0015212","HMDB0255976","HMDB0029384","HMDB0000904;PW_C000723","HMDB0001149","HMDB0029423","HMDB0253418","HMDB0304156","HMDB0001161","HMDB0002024;HMDB0029736;PW_C001357","HMDB0028846","HMDB0000043;PW_C000030","HMDB0029041","HMDB0001847;PW_C001222","HMDB0002393","HMDB0000112;PW_C000071","HMDB0002039","HMDB0000279","HMDB0000177;PW_C000116","HMDB0255958","HMDB0001256;PW_C000970","HMDB0002189","HMDB0001186","HMDB0001325;PW_C001022","HMDB0001257;PW_C000971","HMDB0000870;PW_C000693","HMDB0029044","HMDB0000182;PW_C000118","HMDB0002322","HMDB0013674","HMDB0032914","HMDB0031602;LMFA01030007","HMDB0035904","HMDB0249790","HMDB0003119","HMDB0242173","HMDB0004305;HMDB0243636","HMDB0002434;PW_C001632","HMDB0015303","HMDB0036089;LMPR0102090020","HMDB0000228;PW_C000153","HMDB0034240","HMDB0256117","HMDB0000191;PW_C000123","HMDB0000943","HMDB0249666","HMDB0000139;PW_C000090","HMDB0032055","HMDB0028686","HMDB0252829","HMDB0000360","HMDB0000023","HMDB0028851","HMDB0005766","HMDB0001068;HMDB0258206;HMDB0258206","HMDB0000250;PW_C000170","HMDB0000426","HMDB0000362","HMDB0001489","HMDB0001316;PW_C001015","HMDB0000132","HMDB0028805","HMDB0001341","HMDB0000045;PW_C000032","HMDB0001397","HMDB0000444","HMDB0000193;PW_C000125","HMDB0000254;HMDB0303309;LMFA01170043;PW_C000174","HMDB0000296;PW_C000202","HMDB0011720","HMDB0000056;PW_C000040","HMDB0028818","HMDB0028759","HMDB0001227","HMDB0001314","HMDB0303951","HMDB0029773","HMDB0251539","HMDB0034229","HMDB0039229","HMDB0000195;HMDB0247301;PW_C000127","HMDB0000133;PW_C000087","HMDB0031367","HMDB0006791","HMDB0000085;PW_C000058","HMDB0257445","HMDB0031210","HMDB0000299;PW_C000203","HMDB0302801","HMDB0254095","HMDB0029123","HMDB0000701","HMDB0004256","HMDB0252265","HMDB0038516","HMDB0259742","HMDB0256186","HMDB0012203","HMDB0033192","HMDB0032523","HMDB0001553","HMDB0253184","HMDB0028908","HMDB0029016","HMDB0243710","HMDB0256383","HMDB0034592","HMDB0034441","HMDB0005764","HMDB0253688","HMDB0015190","HMDB0061678","HMDB0030737","HMDB0242384","HMDB0028920","HMDB0251157","HMDB0004999","HMDB0060809","HMDB0251777","HMDB0253028","HMDB0259747","HMDB0013716","HMDB0036156","HMDB0029046","HMDB0251322","HMDB0028903","HMDB0005774","HMDB0247929","HMDB0028993","HMDB0000174","HMDB0031448","HMDB0250840","HMDB0037126","HMDB0258477","HMDB0259877","HMDB0034679","HMDB0251308","HMDB0244551","HMDB0260304","HMDB0254890","HMDB0013063","HMDB0247526","HMDB0254822","HMDB0028832","HMDB0303967","HMDB0028987","HMDB0011745","HMDB0060499","HMDB0039354","HMDB0250496","HMDB0033469","HMDB0255516","HMDB0030795","HMDB0003355","HMDB0247171","HMDB0253366","HMDB0247865","HMDB0249661","HMDB0002171","HMDB0250629","HMDB0000866;HMDB0244966","HMDB0029333","HMDB0293356","HMDB0000706","HMDB0006921","HMDB0028905","HMDB0258927","HMDB0262672","HMDB0034854","HMDB0254368","HMDB0001248;HMDB0252293","HMDB0032604","HMDB0253398","HMDB0249128","HMDB0028744","HMDB0039490","HMDB0059876","HMDB0248615","HMDB0253911","HMDB0256607","HMDB0250335","HMDB0000714;HMDB0011723;HMDB0000714","HMDB0029122","HMDB0251234","HMDB0253011","HMDB0028974","HMDB0262791","HMDB0000750","HMDB0257385","HMDB0250477","HMDB0001520;PW_C001170","HMDB0002107","HMDB0242741","HMDB0242378","HMDB0253027","HMDB0251652","HMDB0013059","HMDB0014391","HMDB0252744","HMDB0033168","HMDB0028830","HMDB0248576","HMDB0000205;PW_C000131","HMDB0255962","HMDB0302720","HMDB0251372","HMDB0249750","HMDB0015593","HMDB0034062","HMDB0000665;LMFA01050381","HMDB0001624","HMDB0125163","HMDB0061384","HMDB0032960","HMDB0000594","HMDB0244967","HMDB0255119","HMDB0059969","HMDB0033954","HMDB0038510","HMDB0244287","HMDB0000512","HMDB0000350","HMDB0002124;LMPK12110005","HMDB0303028","HMDB0011621","HMDB0250549","HMDB0015413","HMDB0029438","HMDB0000707;PW_C000558","HMDB0060682","HMDB0000784;LMFA01170054","HMDB0030003","HMDB0030524","HMDB0302822","HMDB0038661","HMDB0303749","HMDB0062766","HMDB0012286","HMDB0000220;LMFA01010001;PW_C000145","HMDB0034649","HMDB0002327;LMFA01170014","HMDB0000933;LMFA01170002","HMDB0244272","HMDB0034295;LMFA02000147","HMDB0030328","HMDB0255165","HMDB0303767","HMDB0254131","HMDB0035030","HMDB0034153","HMDB0011473","HMDB0059915","HMDB0008824;LMGP02010302;PW_C004872","HMDB0011475","HMDB0001856","HMDB0008834","HMDB0008956","HMDB0011723","HMDB0008825","HMDB0011472","HMDB0249663","HMDB0302163","HMDB0253990","HMDB0011474","HMDB0011471","HMDB0034160;HMDB0034844;LMFA07010812;LMPR0102010015","HMDB0000872;LMFA01170018","HMDB0036583;LMFA02020010","HMDB0303264","HMDB0094645","HMDB0258463","HMDB0036047","HMDB0000623;LMFA01170009","HMDB0303499","HMDB0000888;LMFA01170007","HMDB0249455","HMDB0244269","HMDB0302272","HMDB0257354;LMPK13040018","HMDB0000617","HMDB0012868","HMDB0255554","HMDB0038429","HMDB0253742","HMDB0000424","HMDB0003320","HMDB0244762","HMDB0248728","HMDB0037340;LMPK12110336","HMDB0245646","HMDB0304844","HMDB0000893;LMFA01170001","HMDB0013046","HMDB0033983","HMDB0036626","HMDB0259646","HMDB0251632","HMDB0060897","HMDB0303181","HMDB0253396","HMDB0032496","HMDB0244742","HMDB0254021","HMDB0060685","HMDB0250110","HMDB0302593","HMDB0001901","HMDB0039655","HMDB0304297","HMDB0304803","HMDB0256760","HMDB0000020","HMDB0245370","HMDB0033491","HMDB0242014","HMDB0014710","HMDB0242680","HMDB0000341","HMDB0061026","HMDB0247524","HMDB0000909","HMDB0015267","HMDB0246702","HMDB0035608","HMDB0254473","HMDB0253561","HMDB0280844","HMDB0248539","HMDB0258230","HMDB0013312","HMDB0013061","HMDB0253013","HMDB0035478","HMDB0003601","HMDB0255325","HMDB0028879","HMDB0062318","HMDB0013017","HMDB0031355","HMDB0015090","HMDB0254777","HMDB0259775","HMDB0248600","HMDB0028871","HMDB0253972","HMDB0038956","HMDB0252470","HMDB0256043","HMDB0033613","HMDB0249518","HMDB0259044","HMDB0247235","HMDB0012241","HMDB0038665","HMDB0011757","HMDB0259311","HMDB0015464","HMDB0000563","HMDB0251109","HMDB0029635","HMDB0251628","HMDB0028972","HMDB0039423","HMDB0006695","HMDB0249316","HMDB0000440","HMDB0242632","HMDB0001898","HMDB0254273","HMDB0031935","HMDB0249695","HMDB0252432","HMDB0029081","HMDB0245956","HMDB0038923","HMDB0041887","HMDB0251197","HMDB0030172","HMDB0038546","HMDB0013056","HMDB0303371","HMDB0304894","HMDB0243515","HMDB0028938","HMDB0029015","HMDB0029150","HMDB0014363","HMDB0254917","HMDB0015331","HMDB0000241","HMDB0258577","HMDB0002055","HMDB0031751","HMDB0012161","HMDB0029338","HMDB0035893","HMDB0014378","HMDB0029103","HMDB0273583","HMDB0001476;PW_C001137","HMDB0035865","HMDB0258643","HMDB0005862","HMDB0001786","HMDB0030697","HMDB0059793","HMDB0010357","HMDB0247689","HMDB0039636","HMDB0256114","HMDB0030422","HMDB0252139","HMDB0005765","HMDB0029012","HMDB0240340","HMDB0000542","HMDB0003646","HMDB0000273","HMDB0003640","HMDB0028690","HMDB0253706","HMDB0029019","HMDB0000786;HMDB0002818;HMDB0000786","HMDB0001554","HMDB0249529","HMDB0000289;PW_C000195","HMDB0000126;PW_C000081","HMDB0001429;PW_C001104;PW_C097007","HMDB0000094;PW_C000063","HMDB0062660","HMDB0000302","HMDB0011617","HMDB0000288;HMDB0247871","HMDB0028811","HMDB0000767","HMDB0028724","HMDB0003357","HMDB0000156;PW_C000101","HMDB0000134;PW_C000088","HMDB0034252","HMDB0029158","HMDB0028840","HMDB0002320","HMDB0000641;PW_C000500","HMDB0013222","HMDB0003345;PW_C001851","HMDB0003459","HMDB0033891","HMDB0029054","HMDB0000148;PW_C000095","HMDB0245001","HMDB0000167;PW_C000109","HMDB0033006","HMDB0301807","HMDB0010351","HMDB0000491;PW_C000373","HMDB0001964;HMDB0003501;HMDB0001964","HMDB0004484","HMDB0001401;HMDB0246205;PW_C001083","HMDB0000672;LMFA01170022","HMDB0000691;LMFA01170041;PW_C000543","HMDB0014511;LMST02030119","HMDB0003219"],"LIPID MAPS":["LMSP01040003","LMPR0104180003","LMGP02050015","LMFA08010028","LMGP02050003","LMGP02050008","LMPR0104010009","LMGP02050005","LMPK12110042","LMGP02050004","LMGP02050019"]}}