In order to visualize group separation and find significantly changed
metabolites, supervised orthogonal projections to latent structures
discriminate analysis (OPLS-DA) was applied. Then, a 7-fold cross validation
was performed to calculate the value of R2 and Q2. R2 indicates how well the
variation of a variable is explained and Q2 means how well a variable could
be predicted. To check the robustness and predictive ability of the OPLS-DA
model, a 200 times permutations was further conducted. Afterward, the R2
and Q2 intercept values were obtained. Here, the intercept value of Q2
represents the robustness of the model, the risk of overfitting and the
reliability of the model, which will be the smaller the better.
Furthermore, the value of variable importance in the projection (VIP) of
the first principal component in OPLS-DA analysis was obtained. It
summarizes the contribution of each variable to the model. The metabolites
with VIP>1 and p<0.05 (student t test) were considered as significantly
changed metabolites. In addition, commercial databases including KEGG
(http://www.genome.jp/kegg/) and MetaboAnalyst
(http://www.metaboanalyst.ca/) were used for pathway enrichment analysis
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - positive - HILIC","Liquid Chromatography MS - negative - HILIC"],"chromatography_protocol":["For polar metabolites, LC-MS/MS analyses were performed using an
UHPLC system (Vanquish, Thermo Fisher Scientific) with a Waters ACQUITY
UPLC BEH Amide (2.1 mm × 50 mm, 1.7 μm) coupled to Orbitrap Exploris
120 mass spectrometer (Orbitrap MS, Thermo). The mobile phase consisted
of 25 mmol/L ammonium acetate and 25 ammonia hydroxide in water (A) and acetonitrile (B). The auto-sampler temperature was 4 , and
the injection volume was 2 μL. The Orbitrap Exploris 120 mass spectrometer
was used for its ability to acquire MS/MS spectra on information-dependent
acquisition (IDA) mode in the control of the acquisition software (Xcalibur,
Thermo). In this mode, the acquisition software continuously evaluates the
full scan MS spectrum. The ESI source conditions were set as following:
sheath gas flow rate as 50 Arb, Aux gas flow rate as 15 Arb, capillary
temperature 320 , full MS resolution as 60000, MS/MS resolution as 15000,
collision energy: SNCE 20/30/40, spray voltage as 3.8 kV (positive) or -3.4 kV
(negative), respectively.
"],"publication":["Astaxanthin Protects Against Ferroptosis and Oxidative Stress via Retinoic Acid-Mediated SLC7A11 Regulation by Lepagella muris."],"submitter_affiliation":["Peking University"],"submitter_name":["Duo Keai"],"organism_part":["Bacterial liquid culture medium","Supernatant of the bacterial liquid"],"technology_type":["mass spectrometry"],"disease":[""],"extraction_protocol":["Samples were extracted for metabolites by using the
Starlidworkstation. The 50 ul sample was mixed with 200 ul of extraction
solution(methanol:acetonitrile=1:1 (v/v), including internal standards),
shaken at 750 rpm for 5 min and settled down for 5 min, then filtered
through a protein precipitation plate and the filtrate was collected. The
quality control (QC) sample was prepared by mixing an equal aliquot of the
filtered liquid of samples
"],"organism":["Muribaculum?intestinale","Lepagella?muris","Muribaculum?gordoncarteri","Bacterial liquid culture medium"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS13140"],"author":["shuqi liu. Zhejiang University. 22317016@zju.edu.cn."],"data_transformation_protocol":["The raw data were converted to the mzXML format using ProteoWizard
and processed with an in-house program. which was developed using R and
based on XCMS, for feature detection, extraction, alignment, and integration.
The R package and the BiotreeDB (V3.0) were applied in metabolite
identification.
"],"study_factor":["Group"],"submitter_email":["keaiduoduo998@126.com"],"sample_collection_protocol":["Mix 100μl of bacteria at a concentration of 22 - 550 × 100000 CFU/mL with 100μl of astaxanthin at a concentration of 15 μg/ml. Incubate under anaerobic conditions at 37°C for 24 hours. The medium containing only astaxanthin is defined as the blank control. Conduct metabolomic assays on the entire culture and the blank control.
"],"omics_type":["Metabolomics"],"study_design":["Retinoic Acid","Astaxanthin","Ferroptosis"],"curator_keywords":["Retinoic Acid","Astaxanthin","Ferroptosis"],"mass_spectrometry_protocol":["For polar metabolites, LC-MS/MS analyses were performed using an
UHPLC system (Vanquish, Thermo Fisher Scientific) with a Waters ACQUITY
UPLC BEH Amide (2.1 mm × 50 mm, 1.7 μm) coupled to Orbitrap Exploris
120 mass spectrometer (Orbitrap MS, Thermo). The mobile phase consisted
of 25 mmol/L ammonium acetate and 25 ammonia hydroxide in water (A) and acetonitrile (B). The auto-sampler temperature was 4 , and
the injection volume was 2 μL. The Orbitrap Exploris 120 mass spectrometer
was used for its ability to acquire MS/MS spectra on information-dependent
acquisition (IDA) mode in the control of the acquisition software (Xcalibur,
Thermo). In this mode, the acquisition software continuously evaluates the
full scan MS spectrum. The ESI source conditions were set as following:
sheath gas flow rate as 50 Arb, Aux gas flow rate as 15 Arb, capillary
temperature 320 , full MS resolution as 60000, MS/MS resolution as 15000,
collision energy: SNCE 20/30/40, spray voltage as 3.8 kV (positive) or -3.4 kV
(negative), respectively.
"],"metabolite_name":["Saikosaponin D","2,5-Di-tert-butylhydroquinone","Caprolactam","Pyrocatechol","Malonyl-L-carnitine","Nonanoyl-CoA","Phe-Ile","2-Keto-3-deoxygluconic acid","2-Methylnicotinamide","4-Cresol sulfate","4-Methoxylonchocarpin","Cycloate","Val-Met","Nolatrexed","1-Octen-3-yl_primeveroside","Goralatide (acetate)","4-Methoxybenzyl_O-(2-sulfoglucoside)","L-Erythrulose","5-Hydroxymethyl-2-furancarboxylic acid","N-Nitrosoproline","4-Methoxy-3-geranylgeranyl-1,2-dihydroxybenzene","Norphenylephrine","Ketoleucine","Normorphine","Tacrine","Anhydrocinnzeylanine","Caplamin","Coumatetralyl","2,2',4,4'-Tetrahydroxybenzophenone","Citrulline","Glycolate","D-Erythronic acid .gamma.-lactone","1,5-Naphthalenediamine","Clomipramine (hydrochloride)","juglone","Capric acid","APGPR_Enterostatin","PS(14:0/15:0)","Lofepramine","MITOMYCIN C","1-Hydroxy-2-naphthoic acid","Itopride","Acridine Orange","17-phenyl-trinor-PGE2","cis-?9,?10-?Epoxystearic acid","2-Acetamido-3-(4-hydroxy-3-methoxyphenyl)propanoic acid","Gly-Pro-Arg","4-Hydroxybenzaldehyde","N2-Acetylornithine","N-Methylcalystegine_B2","Perfluoroheptanoic acid","1-Desulfoyessotoxin","Cholic acid 3-glucuronide","Tiapride","Hydroxyprolyl-Isoleucine","2-Methoxy-3,5-dimethylpyrazine","Licoricesaponin G2","5-Carboline","Demethoxycurcumin","Trimellitic acid anhydride","Gamma-glutamyl-Glutamine","Mevalonic acid","2-Hydroxymethyl benzoic acid","Arginine","N,N'-Bis(gamma-glutamyl)cystine","Secobarbital","Dihydroxyfumitremorgin_C","Ethyl_cellulose","[3-[octadec-11-enoyloxy]-2-(octadecanoyloxy)propoxy]phosphonic acid","Ser-Gly","(+)Catechin","4-Hydroxyglutamic acid","LysoPC(18:4(6Z,9Z,12Z,15Z))","Corchoroside_B","Cyproterone_acetate","Cyclopassifloside_VII","Oxiracetam","5-Hydroxylysine","Piperonylic acid","Tetrabenazine","Thaumatin_b,_recombinant","Cinncassiol_C1_19-glucoside","4-Methyl-5-thiazoleethanol","N6-Methyladenine","Pro-Gly","Methylergonovine","Pyridoxal (Vitamin B6)","Isradipine","Vomifoliol_9-[glucosyl-(1->4)-xylosyl-(1->6)-glucoside]","Kainic acid","N-Methyl-L-proline","N-Acetylneuraminic acid","Pantothenic acid","Gln-Pro","Genistein-4'-glucuronide","Yohimbine","7H-Benzo[de]anthracen-7-one","Ritonavir","Omeprazole sulfone","1-Hexanol_arabinosylglucoside","Phe-Gln","Phenylalanine betaine","Ergometrine","Leu-Val","1-O-Hexadecyl-sn-glycero-3-phosphocholine (LPC(O-16:0/0:0))","Xanthurenic acid","Saquinavir","Metaproterenol","1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine","Met-Gly","Acetylglycine","Procyclidine","2-Oleoyl-1-stearoyl-sn-glycero-3-phosphoserine","HEPTANOIC ACID","Phe-Gly","Norophthalmic_acid","Phe-Glu","Torvoside_G","Methanone, (4-ethyl-1-naphthalenyl)[1-(5-fluoropentyl)-1H-indol-3-yl]-","Rucaparib","25-Acetylvulgaroside","Diethylthiophosphate","Mupirocin","Prolylalanine","Corchoionoside_B","alclometasone_dipropionate","2-Phenyllactic acid","Methylguanidine","(2-aminoethoxy)[3-(hexadecanoyloxy)-2-[icosa-5.8.11.14-tetraenoyloxy]propoxy]phosphinic acid","Asparaginyl-Valine","Ornithine","2-amino-3-({hydroxy[2-(icosanoyloxy)-3-[octadec-11-enoyloxy]propoxy]phosphoryl}oxy)propanoic acid","4-Acetamidobutyric acid","3-Methyladenine","PS(18:0/18:2)","3-Hydroxybenzoic acid","arctiin","Ibotenic acid","Carbidopa","N-Phenylacetamide","Isoniazid (Drug)","Serine","Arg-Pro","Norsufentanil","8-Shogaol","S-Allyl-L-Cysteine","Pisumoside_A","Diazinon","(Phenoxymethyl)penicilloic acid","Promethazine sulfoxide","Phe-Thr","Phenylsulfate","7,11,12-Triacetoxycoumestan","Asp-Glu","Tyr-Gly","Melphalan",".alpha.,.alpha.'-Trehalose 6-phosphate","2,4-Diamino-6,7-dimethoxyquinazoline","Cinnzeylanine","LPC(18:1)","Valylphenylalanine","2-[4-(4-Chloro-1,2-diphenyl-1-buten-1-yl)phenoxy]-N,N-dimethylethanamine","Adenosine","PC(16:0/18:1(9Z))","Methyl acetoacetate","Allopurinol","PIP(16:1(9Z)/18:0)","2-Oxovaleric_acid_","(S)-Cotinine N-oxide","Glycinoeclepin_C","Pro-Ile","2-Hydroxycinnamic acid","L-tyrosine-methyl-ester","Linoleic acid","PC(18:0/18:3(6Z,9Z,12Z))","Cilostamide","Propanoic acid, 3-[[[4-[4-[[[1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3- methyl-5-isoxazolyl]phenyl]methyl]thio]-","Tacrolimus","Ganoderic_acid_Mi","Benazepril","Arg-Asp","LIMONIN","Arg-Asn","PC(18:0/18:1(9Z))","5-Amino-4-carbamoylimidazole (AICA)","Triamcinolone","PS(14:0/14:1(9Z))","O-Methyl-DL-serine","Tri(butoxyethyl)phosphate","2-Amino-3-(1H-pyrazol-1-yl)propanoic acid","Betonicine","Benzoic acid","Daidzin","Candesartan","5-Methylcytosine","PC(15:0/P-18:0)","Argatroban","Methylsuccinic acid","Trp-Gly","karanjin","Glycolithocholic acid 3-sulfate","Thr-Ser","Dalfopristin","O-Acetylserine","3'-O-Methylguanosine","Merodesmosine","5-(N-Ethyl-N-isopropyl)amiloride","PA(20:4(5Z,8Z,11Z,14Z)/20:3(8Z,11Z,14Z))","5-Hydroxymethylfurfural","Ferulic_acid_4-sulfate","L-Acetopine","Sphingosine","(2R)-6-Oxo-2-piperidinecarboxylic acid","Chlorhexidine","1-Hydroxy-3,5-dimethoxy-2,4-diprenylxanthone","L-3-Aminoisobutyric acid","1,2-Distearoyl-sn-glycero-3-phospho-L-serine","6-Formylpterin","gamma-Glutamylleucine","4-Imidazolidineheptanoic acid, 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-","2-Ketobutyric acid","(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate","Lys-Leu","N-Acetyl-arginine","Bortezomib__","Kaempferol 3-ss-D-galactoside","Telmisartan","Tiglic_acid","Paracetamol (Drug)","Valeric acid","His-Ser","Gibberellic_Acid","Nitrofurazone","Lysine","SM(d18:1/17:0)","Cyclobenzaprine","S-(2-Hydroxyethyl)glutathione","Butyllactate","Thymol blue","Hexobarbital","Trehalose","Pro-Gly-Pro","2-Methylbutyrylglycine","alpha-Ketoglutaric acid (alpha-KG)","(3xi,6xi)-Cyclo(alanylvalyl)","Lys-Asp","5-Amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid","Talbutal","Lys-Asn","2-O-Methylcytosine","2'-Aminoacetophenone","Betanidin","Dihydro-6-isopropyl-2,4-dimethyl-4H-1,3,5-dithiazine","Guanine","SM(d18:0/18:0)","7-Hydroxyamoxapine","Corynanthin","Ethyl 3-(N-butylacetamido)propionate","3'-Hydroxy-T2_Toxin","SECO-ISOLARICIRESINOL_DIGLUCOSIDE","N-Acetylphenylalanine","Bursin","Acetic acid, 2-[[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-","Cytidine 5'-monophosphate (CMP)","1,2,3,4-Tetrahydro-2-methyl-b-carboline","Taraxinic_acid_glucosyl_ester","Annoglabasin_C","Glu-Val","Xanthosine","Isoxaben","Perseitol","Cysteine-glutathione disulfide","Digitoxigenin_3-[glucosyl-(1->6)-glucosyl-(1->4)-2,6-dideoxyribohexoside]","3-Methyl-2-oxovaleric acid","4-Hydroxytriamterene","Mannose 1-phosphate","Glycylleucine","N'-Nitrosonornicotine","7-Methylguanine","Nicardipine","Ala-Arg","cis-9-Palmitoleic acid","Pefloxacin","Ssioriside","Monomethyl phthalate","Evobioside","Cytidine 5'-diphosphate (CDP)","Hydroxyisocaproic acid","Glabrol","Mepirizole","LysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z))","Milrinone","Pravastatin","Inosine 5'-monophosphate (IMP)","Phe-Val","Pipecolic acid","papaverine","p-Coumaroylputrescine","Ranolazine","Prolyl-Serine","Pteroside_B","Glucose 6-phosphate","Lys-Pro","2'-Deoxyuridine","Indole-3-carboxaldehyde","Ala-Pro","Stachyose","Stearic acid","Orotidine","PI(20:1(11Z)/20:4(8Z,11Z,14Z,17Z))","Ethynodiol_diacetate","2-Ethylpyrazine","1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1'-myo-inositol)","Cinncassiol_E","Ethyl 4-hydroxybenzoate","Velcorin","Dipiperamide_D","Dipiperamide_C","Dipiperamide_A","Mometasone_furoate","Ala-Asp","Glutamate","Cinncassiol_A","Succinic_anhydride","Calycin","Carnitine","Hydroquinone","Creatine, ethyl ester","Acuminoside","N1,N5,N10-Tris-trans-p-coumaroylspermine","DG(24:0/22:1(13Z)/0:0)","RU-0211","7,8-Dihydro-3b,6a-dihydroxy-alpha-ionol_9-glucoside","Zolpidem","Americine","PC(P-16:0/18:4(6Z,9Z,12Z,15Z))","Givinostat","DL-Isocitric acid lactone","Garcinone C","LPC(16:0)","Pteroside_Z","3-Benzoyloxy-11-oxo-12-ursen-28-oic_acid","Lenalidomide__","Genistein","Bazedoxifene","Isophysalin_G","5-Hydroxykynurenine","Vardenafil","Alanylalanine (Ala-Ala)","Cinitapride","Tejedine","b-Ala-Lys","PC(20:4(8Z,11Z,14Z,17Z)/15:0)","1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine","Allysine","Acetic acid, 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-","Isobutyrylcarnitine (Car(4:0))","3-ketosphinganine","N6,N6,N6-Trimethyllysine","3-[(5-Oxo-2-pyrrolidinyl)carbonyl]-1,3-thiazolidine-4-carboxylic acid","(3E)-4-(1-Hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl)but-3-en-2-yl 6-O-pentopyranosylhexopyranoside","2,4,6-Trimethylpyridine","His-Lys","(2-aminoethoxy)[2-[octadec-9-enoyloxy]-3-[octadeca-1.11-dien-1-yloxy]propoxy]phosphinic acid","Piperolein A","PI(16:0/18:1)","Gramine","N-Benzyladenine","Acetyl tributyl citrate","Thymine","2-Acetamidooctanoic acid","1-Hydroxyalprazolam","Isocyclomorusin","Pelargonic acid","2-Hydroxyglutaric acid","1-Methyladenosine","Tamsulosin","Koryoginsenoside_R1","Harmaline_hydrochloride_dihydrate","N-Acetylglucosamine 1-phosphate","TOBRAMYCIN","schisandrin B","Propanedinitrile, 2-[(3,4,5-trihydroxyphenyl)methylene]-","Asn-Gly","4-Hydroxyisoleucine","Dihydroorotic acid","Maltol","Sarcosine","4-Hydroxyphenylacetic acid","Sinomenine","Dihydroneopterin_phosphate","1-(2-Pyrimidyl)piperazine","Vinaginsenoside_R14","2-(1-Propenyl)-delta1-piperideine","Taurine","N-Acetylgalactosamine","N-Acetyl-2-carboxybenzenesulfonamide","((6-O-Hexopyranosylhexopyranosyl)oxy)(phenyl)acetonitrile","Zalcitabine","Histidylproline diketopiperazine","2,3-Dihydroxy-3-methylbutyric acid","2-Aminonicotinic acid","O-Phosphoethanolamine","Ochratoxin A","Pipercyclobutanamide_B","Adlupone","Maltobionate","Trospium","kaempferol 7-neohesperidoside","Gly-Pro-Glu","Trifluoroacetic acid","Pirbuterol","[2-(4-Aminofurazan-3-yl)-1-ethylimidazo[4,5-c]pyridin-7-yl]methyl-(4-piperidyl)amine","3-Phosphoserine","Trimethobenzamide","Ichangin_4-glucoside","Ticagrelor","D-Glucosaminide","Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-","Sph(d18:0)","Carbamoyl_phosphate","Trigonelline","2-Carboxy-1-[5-(2-carboxy-1-pyrrolidinyl)-2-hydroxy-2,4-pentadienylidene]pyrrolidinium","(.+/-.)-Dropropizine","Diclofensine","8-Hydroxyguanosine","5-Hydroxymethyltolterodine","1,1'-Ethylidenebistryptophan","Retinoic acid (Vitamin A acid)","Diacerein","3,3',5'-Triiodo-L-thyronine","Pentoxifylline","2-Phenylethynesulfonamide","Prometon","Isovalerylglutamic_acid","PC(18:1(11Z)/15:0)","Diphacinone","Enalaprilat (dihydrate)","trans-Vaccenic acid","Isoleucylvaline","Dabigatran_etexilate","S-(PGA1)-glutathione","1-Methylguanosine","Troglitazone","PC(18:1(9Z)/P-16:0)","N-nornuciferine","Ferrioxamine_B_[M+Fe-2H]","Loperamide","Topiramate","Oleanane -2H, +1O, 1COOH, O-HexA-HexA","Notoginsenoside_R9","Undecanoic acid","Cassythicine","trans-Aconitic acid","ACARBOSE","2,5-Dimethylpyrazine","Kiwiionoside","Roquefortine","Virolongin_B","[2-[4-Methyl-2-(2-methylpropanoyloxy)phenyl]oxiran-2-yl]methyl 2-methylpropanoate","Fructose 1-phosphate","Cystine","Val-Ile","2-Aminobutyric acid","Ganoderenic_acid_E","4-(Dimethylamino)pyridine","4-Hydroxymethylpyrazole","Ebastin","Atipamezole","Canescein","Nigellicine","(8S,8'S)-Secoisolariciresinol_9-xyloside","Phenylalanine","Car(18:0)","Estriol-17-glucuronide","3-Methyl-.gamma.-butyrolactone","Prolylhydroxyproline","Biotin sulfone","Pyrogallol","Pentaethylene glycol","pibutidine","Benzamidine (hydrochloride)","Dofetilide","Eremopetasitenin_B2","Uracil","Myosmine","Tetradecenedioylcarnitine (Car(14:1-O2))","Meclozine","Quinapril","CRUSTECDYSONE","Crotonic acid","Tryptamine","Trp-Trp","Phloroglucinol","Amisulpride","Promazine","Creatine","5-Aminolevulinic acid","Caprylic acid","Maraviroc","S-Furanopetasitin","4-Methylbenzoic-acid","SM(d18:1/18:0)","PA(20:5(5Z,8Z,11Z,14Z,17Z)/20:4(5Z,8Z,11Z,14Z))","Furanylfentanyl","Cytosine","Risperidone","Asp-Asp","Kuwanon C","Pro-Phe","N-Acetylsulfamethoxazole","N6-Methyladenosine","Harderoporphyrinogen","4-Acetamido-2-amino-6-nitrotoluene","Tolazoline (hydrochloride)","N2,N2-Dimethylguanosine","Bisoprolol","Guanidinosuccinic acid","7,8-Dihydroxyflavone","N2-(1-Oxo-4-phenylbutyl)-L-glutamine","Doramapimod","Diflufenican","Tryptophyl-Methionine","Oxalic acid","Carvedilol","N,N-Dimethylarginine (ADMA)","Tyr-Arg","Beclomethasone dipropionate","Taraxacolide_1-O-b-D-glucopyranoside","SR271425","3,4-Dihydroxymethamphetamine","Pehanorm","Triacetyl resveratrol","4'-Methylliquiritigenin_7-rhamnoside","PE(P-36:4)","Kuwanon_L","(3b,20R,22R)-3,20,27-Trihydroxy-1-oxowitha-5,24-dienolide_3-glucoside","Cyclanilide","Pimozide","O-Desmethylastemizole","Val-Val","(2S)-4-amino-2-[(azaniumylacetyl)amino]-4-oxobutanoate","Retrocalamin","Gln-Thr","Apigenin 7-glucoside","LPC(18:0/0:0)","Homocarnosine","PA(18:4(6Z,9Z,12Z,15Z)/18:4(6Z,9Z,12Z,15Z))","Chromocarb","UDP-N-acetylglucosamine","Olmesartan","Ser-Pro","5,7-Dihydroxy-6-methoxyflavone_5-rhamnoside","Pesticide4_Boscalid_C18H12Cl2N2O_3-Pyridinecarboxamide, 2-chloro-N-(4'-chloro[1,1'-biphenyl]-2-yl)-","9,10-Dihydro-2,3,5,7-Phenanthrenetetrol","O-b-D-Gal-(1->3)-O-[O-b-D-Gal-(1->4)-2-(acetylamino)-2-deoxy-b-D-Glc-(1->6)]-2-(acetylamino)-2-deoxy-_D-Galactose","8-Oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl hexopyranoside","Piperanine","Isoleucine","2-Methyl-3-hydroxybutyric acid","2-Phenylethyl 6-O-pentopyranosylhexopyranoside","Cyanidin-3-glucoside","2,5-Dimethyl-3-(1-propenyl)pyrazine","Arachidonic acid (AA)","Canrenone","2-Methylhippuric acid","Pyruvate","Lys-Met","Threonic acid","Canertinib","LysoPC(18:3(6Z,9Z,12Z))","2,2'-Iminodiacetic acid","Myristicanol_A","Heptadecanoic acid","Doxycycline","Citraconic acid","Repaglinide","1-Deoxy-D-glucitol","Amobarbital","Arg-Thr","Rifaximin","Norepinephrine","Cytidine 5'-diphosphocholine (CDP-choline)","Dimethylglycine","1-O-trans-cinnamoyl-beta-D-glucopyranose","3-Hydroxyphenylacetic acid","Glutamine","1,2-Dimethylimidazole","5-Amino-6-ribitylamino uracil","Cymorcin_diglucoside","Darunavir","Phenylacetic acid","Caproic acid","PE(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)","Dihydroxyacetone phosphate","Palmitic acid","sn-Glycerol 3-phosphate","Sucrose_acetate_isobutyrate","1,3-Bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea","Histidine","Benzamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-","Convallatoxin","Canesceol","4-Hydroxycinnamic acid","Saccharopine","Inositol_cyclic_phosphate","clemastine","Valtratum","Tyramine","Isoamylamine","Arg-Pro-Pro","Allopurinol-1-ribonucleoside","Phenylbutazone","1-alpha-Acevaltrate","Amlexanox","Glycyl-glutamate","Propionylcarnitine (Car(3:0))","Gly-Val","Deoxyadenosine","20-hydroxy-LTE4","Pergolide","Isopetasoside","Ser-Ala","Prednicarbate","piritramide","Isobutyric_acid","LysoPE(24:6(6Z,9Z,12Z,15Z,18Z,21Z)/0:0)","Bifemelane","Glycerophosphocholine","Azetidine-2-carboxylic acid","Glimepiride","Olitoriusin","Norisodomesticine","Amikacin","Physalin_L","Rosoxacin","MLS001148159-01!METHYLPREDNISOLONE","1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-.alpha.,.alpha.- dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid","Thr-Leu","Betavulgaroside_VII","Thiethylperazine","Hydrocortamate","Indoleacetic acid","Desbenzyl donepezil","3-Pyridylacetic acid","N-Methylglutamic acid","Edaravone","Acadesine (Drug)","Presqualene_diphosphate","Hydroxyphenyllactic acid","Benzamide, N-[2-(dimethylamino)ethyl]-N-methyl-4-[[[[4-[4-(4-morpholinyl)-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl]amino]carbonyl]amino]-","N-Lactoylphenylalanine","L-Alanyl-L-leucine","PC(P-18:0/18:1(9Z))","Alanine","2-Methylguanosine","gamma-Glutamylglutamine","Phosphoenolpyruvic acid","Levulinic acid","3-Pyridinecarboxaldehyde","Codeine-6-.beta.-D-glucuronide","N-Acetylputrescine","Tryptophan","Fluvoxamine_acid","Falcarinolone","Xanthine","Desmethylverapamil","Fructose 6-phosphate","Nobiletin","His-Leu","Physoperuvine","PC(16:0/20:4)","Choline","Asparagine","Schizandrin","(10E,15Z)-9,12,13-Trihydroxyoctadeca-10,15-dienoic acid","2-Anilinopropanoic acid","Leucylphenylalanine","(1R,3R,4R,5S,6S,8x)-1-Acetoxy-8-angeloyloxy-3,4-epoxy-5-hydroxy-7(14),10-bisaboladien-2-one","Betamethasone-17-valerate","(Sulfanylsulfonyl)methane","(8R,8'R)-Secoisolariciresinol_9-glucoside","PG(16:0/18:1)","Arg-Phe","1-isothiocyanato-8-methanesulfinyloctane","Gymnodimine","Sesamin","Aniline","Isopalmitic_acid","Adenosine monophosphate (AMP)","Methylhalfordinol","Phenylpropionylglycine","Lopinavir_(ABT-378)","Isobutyrylglycine","Ala-Lys","o-Tyrosine","Cinnamoside","2-Aminopurine","3-Amino-4-methylpentanoic acid","Indoxyl sulfate","Docetaxel","Galactaric acid","trifolirhizin","Cytidine 2',3'-cyclic phosphate","Phosphorylcholine","2-[4,6-Bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl]-5-(octyloxy)phenol","a-L-Fucopyranosyl-(1->2)-b-D-galactopyranosyl-(1->2)-D-xylose","Val-Gly","PE-NMe2(14:0/14:0)[U]","2,4-Dihydroxybenzophenone","Erlotinib","2-Hydroxy-2-methylbutyric acid","Quinidine","Dimethyl sulfoxide","ZON","(-)-trans-4-[4-(4'-Fluorophenyl)-3-piperidinylmethoxy]-2-methoxyphenol","Mildronate","Protoporphyrin IX","Pyruvaldehyde","Rifapentine","Methysergide","3'-Hydroxystanozolol","1H-Indazole-4-carboxamide, N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-","5-Hydroxyoxindole","Thr-Pro","Colistin","Nitrazepam","Rolitetracycline","PA(18:4(6Z,9Z,12Z,15Z)/18:2(9Z,12Z))","Leucine","CHES","4-Hydroxyphenylpyruvic acid","Icariside_E5","Maltoheptaose","PA(20:5(5Z,8Z,11Z,14Z,17Z)/15:0)","Piperidine","Pro-Pro","Arg-Ala","(3-Aminopropyl)(diethoxymethyl)phosphinic acid","2-Stearyl_citrate","Atazanavir","His-Pro","Indolmycin","Dethiobiotin","Maltohexaose","Rosmaricine","7-Hydroxyfluphenazine","Alpha-Trisaccharide","Phenoxybenzamine","Thr-Cys","Irinotecan","11,12,14-Trihydroxy-7-methoxy-8,11,13-abietatrien-20,6-olide","Coroloside","Vanillin","Enzastaurin","2'-Deoxyguanosine 5'-monophosphate (dGMP)","PC(18:2(9Z,12Z)/P-16:0)","1,7-Dimethylxanthine","5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole","Thr-Phe","Doxazosin","1-O-Octadecyl-sn-glyceryl-3-phosphorylcholine","Lacto-N-triose_I","2'-O-Methyluridine","Levetiracetam (Drug)","Riboflavin","1-Propanesulfonamide, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-","Ramipril","MeAIB","Prolyl-Tyrosine","Metyrapol","Deoxyinosine","Aminoglutethimide","3-cis-Hydroxyglipizide","1,8,9-Anthracenetriol","Manidipine (Manyper)","2-Ketocaproic acid","Succinic_acid_semialdehyde","(9R,10S,12Z)-9,10-Dihydroxy-8-oxo-12-octadecenoic_acid","N-Acetylvaline","Hexanoylglycine","Cediranib","2-Methylbenzoic acid","Dimethyl hydrogen phosphate","Mangostine","Licoricesaponin_D3","Lys-Val","Harman","2-Methyl-4'-(methylthio)-2-morpholinopropiophenone","Nitecapone","Tropinone","Biotin","EZETIMIBE","Arecoline","(2S,4S)-Monatin","Ligustrazine","Octadecanedioic acid","Enoxacin (hydrate)","Daphniphylline","Ampicillin","(R)-5-Methylhydantoin","CerP(d18:1/12:0)","Divanillyltetrahydrofuran_ferulate","N-Acetylaspartic acid","Armillaridin","Mesaconic acid","Chemotatic Peptide","PS(14:1(9Z)/20:1(11Z))","L-Fucitol","Glucosylgalactosyl_hydroxylysine","Lamotrigine","N-Desmethyl imatinib","Flavanone base + 6O","Heptane-1-thiol","Kanamycin A","Leucyl-Methionine","Eriojaposide_A","16:0 PE (1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine)","Lauric diethanolamide","Arabinono-1,4-lactone","Glycine","Iloperidone","Valyl-Glycine","Arg-Val","Oleic acid","Glu-Arg","Cystathionine","Glutaric acid","Deoxypyridinoline","AFN911","2'-O-Methyladenosine","2,6-Dimethylpyrazine","Olean-12-en-28-oic acid, 2,3,23-trihydroxy-, (4.alpha.)-","N-Acetylglutamic acid","Isolimonic_acid","3-HYDROXYGLUTARIC ACID","Oxibendazole","DMPO","Ser-Ser","Pseudouridine","Butyrylcarnitine (Car(4:0))","MLS001077323-01!51333-22-3","2-Dimethylamino-6-hydroxypurine","Chloropanaxydiol","Secoisotetrandrine","Terephthalic-Acid","Luminespib","1-O-Hexadecyl-2-O-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glyceryl-3-phosphorylcholine","N-Acetylcadaverine","Ophiopogonin_C","His-Val","Isolupalbigenin","Ifenprodil","Goshonoside_F1","Dihydrocapsaicin","Posaconazole","Octocrylene","Lucidenic Acid E2","Aminocarb","Tyrosylalanine","Isovaleric acid","Guanosine","4-Hydroxymephenytoin","Protopine","Ribothymidine","7-Keto-8-aminopelargonic acid","Glycochenodeoxycholic_acid_3-glucuronide","5-Acetylamino-6-amino-3-methyluracil (AAMU)","Paradisin_C","Hydromorphone-3-.beta.-D-glucuronide","Cysteine S-sulfate","Clausarinol","Gambogic_acid","D-Pinitol","Glu-Ala","Murrayazolinol","PyroGlu-Trp","6,7-Didehydrofevicordin_F_3-[glucosyl-(1->6)-glucoside]","Bipindogulomethyloside","Gamma-glutamyl-Glycine","Piracetam","Glyceric acid","AFMK","Lactaldehyde","Imatinib","2-amino-3-({[3-(hexadecanoyloxy)-2-(octadecanoyloxy)propoxy](hydroxy)phosphoryl}oxy)propanoic acid","isepamicin","Lys-Ile","Flavanone base + 5O","2-Aminoisobutyric acid","Loganin","trans-Zeatin","Cyclohexanecarboxamide, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-","PC(P-32:0)","Homocitric acid","Hecogenin","Xylose","Palmitoyl sphingomyelin","Phosphonic acid, P-[[4-[(1-oxotetradecyl)amino]phenyl]methyl]-","Bismurrayafoline_E","L-Prolyl-L-leucylglycylamide","L-Thyronine","1-Methylguanine","Pyrophosphate","Uridine","Putative Phenylalanine conjugated chenodeoxycholic acid","Imazamox","prednisone","N6-Methyllysine","Sulfaphenazole","1-oleoyl-2-myristoyl-sn-glycero-3-phosphocholine","4-Hydroxyphenylacetaldehyde","Lymecycline","Malonic acid","Tapentadol-.beta.-D-glucuronide","2-Hydroxyadenine","Proline","Ala-Met","Asticolorin_B","Coagulin_R_3-glucoside","Vilazodone","6-Acetyl-2,3-dihydro-2-(hydroxymethyl)-4(1H)-pyridinone","Licoagrone","Aspartyl-Glycine","Polysorbate_20","Epicatechin gallate","Epidermin","3-Hydroxypropionic acid (beta-lactic acid)","Methiocholic acid putative","Marimastat","2-Acetamidophenol","Glutarylcarnitine","Thr-Ala","Pesticide3_Carbofuran_C12H15NO3_Furadan","3-Nitrotyrosine","1-(2-Methyl-5-nitro-1H-imidazol-1-yl)-2-propanol","Gly-His","Caftaric_acid","Thiamine","LACTULOSE","Nelarabine__","TRH, free acid","N-Acetyltryptophan","Phe-Lys","Testosterone_glucuronide","2,4-Dihydroxybutanoic acid","Allose","leonurine","5-Nitro-2-propoxyaniline","His-Ile","Taxiphyllin","(1xi,3S)-1,2,3,4-Tetrahydro-1-methyl-beta-carboline-1,3-dicarboxylic_acid","Fumaric acid","N1,N10-Diferuloylspermidine","3-O-p-trans-Coumaroylalphitolic_acid","1-(3-carboxypropyl)-3,7-dimethylxanthine","Desferrioxamine B + Al (M-2H+Al)","Fomepizole","Phenylpyruvic acid","3-Hydroxycinnamic acid","4-Hydroxybenzyl_isothiocyanate_rhamnoside","Clarithromycin","Phe-Pro","1-(3,4-Diethoxybenzyl)-6,7-diethoxyisoquinoline","Sucrose","Phenylalanylphenylalanine","Trihexyphenidyl","Daltogen","beta-Cyano-alanine","Mannose","Clitocine","Dodecyl gallate","Strictosidine","Glycylproline","N-[2-(4-Prenyloxyphenyl)ethyl]tiglamide","DL-Threonine methyl ester","Artesunate","Ethylsuberenol","8-Isobutanoylneosolaniol","2-[2-[19-acetamido-6-(3,4-dicarboxybutanoyloxy)-16,18-dihydroxy-5,9-dimethylicosan-7-yl]oxy-2-oxoethyl]butanedioic aci","2-Aminonaphthalene","[1-hydroxy-1-(4-methoxyphenyl)propan-2-yl] 4-methoxybenzoate","Cephaeline","3'-O-Methyladenosine","Sakacin_A","Taurocholic acid","Aflatoxin M1","Methoxyfenozide","Dovitinib","Val-Pro","Acetylsalvipisone","Spectinomycin","Moracin_J","3-METHYLGLUTACONIC ACID","Roflumilast","Urocanic acid","Imidafenacin","guanadrel","DL-.alpha.-Phenylglycine","Pirenperone","Fagomine","9-Hydroxyrisperidone","Riboflavine_2',3',4',5'-tetrabutanoate","Egtazic acid","2-Aminopimelate","Demecolcine","Ivacaftor","Arg-Gly","N-Acetylglucosamine","Nefazodone","Dihydroergocristine","Formyl-5-hydroxykynurenamine","Oxaprozin","Tetraethylene glycol","3-Pyridinemethanol","Isoglobotriaose","5-Hydroxydopamine","Olmesartan medoxomil","Astemizole","Benzamide, 2-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)-","5'-Methylthioadenosine","Oxacillin","Hydroxyacetone","Acetophenone","2-Hydroxypyridine","Mepacrine","Creatinine","His-Glu","Polypodoside_B","3-Aminobutanoic acid","2-Aminoheptanoic acid","Aspartate","Quinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-","Guanosine 5'-diphosphate (GDP)","Pyridoxine","Emodin","4-Amino-2-methyl-5-pyrimidinemethanol","Formiminoglutamic acid","5-Aminopentanoic acid","Valine","Stachydrine","Leu-Trp","His-Gln","Muramate","Thr-Gly","Actarit","Canavalioside","Hexaethylene glycol","Cis-Caffeoyl_tartaric_acid","FAPy-adenine","Theobromine","S-(2-Carboxypropyl)glutathione","3-Methoxy-4-hydroxyphenylglycol sulfate","Glu-Asp","5-Methyldeoxycytidine","Alliospiroside_C","Itaconic acid","Leu-Leu","5-Fluorouridine","Acetaminophen sulfate","Betaine","Tetraglyme","N-Methylhydantoin","2-Propyl-4-pyridinecarbothioamide","Neoquassin","Everolimus","Erythroskyrin","Nortriptyline","Kenposide_B","Triparanol","4-Hydroxy-4-(3-pyridyl)-butanoic_acid","tripamide","Mesaconitine","2-Hydroxy-3-methylbutyric acid","1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine","Ponatinib","Cytidine","Pipernonaline","hexadecanedioic_acid_mono-L-carnitine_ester","1,2,3,4-Tetrahydroisoquinoline-7-sulfonamide","Leucylleucyltyrosine","Glu-Asn","Fusarin_C","Candoxatril","Succinamide","Pyridostigmine","PS(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","Asparagoside_B","5,6-Isopropylidene-L-ascorbic acid","Delphinidin_3-lathyroside_5-glucoside","Alfuzosin","N-(2-furylmethyl)-9H-purin-6-amine","H-Val-Ala-OH","Imazamethabenz-methyl","PS(22:4(7Z,10Z,13Z,16Z)/20:1(11Z))","Dimethylbenzimidazole","O-Methylganoderic_acid_O","1,2,3-Tris(1-ethoxyethoxy)propane","1-Methylhistidine","Dodecanoic acid","Isoleucyl-Threonine","HERALENOL","Kukoamine_C","5-Hydroxyrosiglitazone","Isomorellic_acid","PC(18:3(9Z,12Z,15Z)/18:1(9Z))","Norethindrone","Phenethyl rutinoside","Coumachlor","(.+/-.)-Mahanine","Sulfanilic acid","PC(18:1(9Z)/18:1(9Z))","Blumealactone_A","Ramiprilat","1-(4-Hydroxy-3,5-dimethoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-3,5-heptanediol","Glycerophosphoethanolamine","Capsicum_annuum_Fluorescent_chlorophyll_catabolite","Pipotiazine","Glycyl-Lysine","2-Hydroxyethanesulfonic acid","Gly-Ser","Marbofloxacin","2-Naphthalenethiol","Methyl_7-epi-12-hydroxyjasmonate_glucoside","Butyl_3-O-caffeoylquinate","Vincristine","13(S)-HODE","Flavoxate","Codeine","Hydroxyzine","Fluocinolone acetonide","Ethyl_7-epi-12-hydroxyjasmonate_glucoside","4-[2-(2,6-dimethoxy-4-prop-2-enylphenoxy)-1-hydroxypropyl]-2-methoxyphenol","Tetraphyllin_B","Pentylenetetrazole","Glu-Pro","N-Acetylalanine","Phe-His","Flunitrazepam","Isonicotinic acid","(S)-2-Ureidopentanedioic acid","Gallocatechin","Allantoin","Embelin","Spiroxamine","2-methylcitrate","Bistris","Lormetazepam","7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine, N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-","Fumitremorgin_C",".beta.-D-Glucopyranosiduronic acid, 4-(7-hydroxy-4-oxo-4H-1-benzopyran-3-yl)phenyl","Fructose 1,6-bisphosphate","N2-Acetyllysine","Dihydroferuperine","Methyl red","N-Carboxyethyl-gamma-aminobutyric_acid","Piperacillin","4-Guanidinobutyric acid","1-Hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine","5-Hydroxytryptophan","N-Carbamoyl-2-amino-2-(4-hydroxyphenyl)acetic_acid","4-Fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]phenol","3-Aminophenol","Kynurenic acid","Adenosine 3'-monophosphate","beta-Alanine","Phe-Trp","1,2,3,6-Tetrahydropyridine-4-carboxylic acid","Netilmicin","1-Methylpyrrolidine","Blumenol_C_O-[apiosyl-(1->6)-glucoside]","Etofylline","Methionine","1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-","alpha-Ketoisovaleric acid","Sinapine","(2-aminoethoxy)[3-[hexadec-1-en-1-yloxy]-2-[icosa-5.8.11.14-tetraenoyloxy]propoxy]phosphinic acid","4-((3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-(((2R,4S,5S,6R)-5-(((2S,4S,5S,6R)-5-(((2S,4S,5S,6R)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-12,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one","Trifluperidol","Nalbuphine","9-Oxooctadecanoic acid","(2-aminoethoxy)[2-[icosa-5.8.11-trienoyloxy]-3-[octadec-1-en-1-yloxy]propoxy]phosphinic acid","alpha-Keto-gamma-(methylthio)butyric acid","1-Methyl-3-indoleacetic acid","Androstendione","LysoPC(20:4(5Z,8Z,11Z,14Z))","4-Hydroxyproline","Cholesteryl sulfate","Methyl_helianthenoate_A_glucoside","Avocadyne Acetate","Gabapentin","4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol","Celastrol","Isovalerylcarnitine (Car(5:0))","Austalide D","alpha-Chaconine","Carnosine","Ubiquinol_8","3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione","N-Formylglycine","gamma-Glutamylglutamic acid","Neostigmine","Lincomycin","Linoleamide","Ile-Pro","Phosphate","isoimperatorin","Glycerol_trihexanoate","Hexamethylquercetagetin","Solacauline","3,5-dihydroxydecanoic acid","Pentadecanoic acid","3-[[4-(4-Chlorophenyl)piperazino]methyl]-1H-pyrrolo[2,3-b]pyridine","PS(22:2(13Z,16Z)/20:2(11Z,14Z))","Kojic acid","Kanokoside_A","Penciclovir","Galactinol","3',5'-Cyclic guanosine monophosphate (cGMP)","Pentacarboxyl_porphyrinogen_III","Benzoic acid, 2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]-","Hydroxyprolyl-Proline","Ginsenoside_Rb2","Guanosine 5'-monophosphate (GMP)","3-Phenylpropanoic acid","PS(20:5(5Z,8Z,11Z,14Z,17Z)/14:1(9Z))","2-QUINOLINECARBOXYLIC ACID","Phe-Leu","Flurandrenolide","Glu-Gly","Farnesylcysteine","Pipericine","DG(20:5(5Z,8Z,11Z,14Z,17Z)/18:1(11Z)/0:0)","Glu-Glu","Ginsenoside_Re","Ile-Pro-Ile","Indolelactic acid","Norleucine","Lagerstroemine","Ribulose 5-phosphate","Fusidic_acid","Nilutamide","Aprobarbital","Barbital","Gossypol","3-(3,4-Dihydroxyphenyl)-2-hydroxypropanoic acid","LysoPE(18:4(6Z,9Z,12Z,15Z)/0:0)","Xanthotoxol","butabarbital","Tyrosylglutamic acid","Mimosine","pGlu-Glu-Pro-amide","[3-[[2,3-dihydroxypropoxy]-hydroxyphosphoryl]oxy-2-hexadecanoyloxypropyl] hexadecanoate","3-Methyluridine","Aminopicoline","matairesinol","2-Isopropyl-6-methoxypyrazine","Tryptophol_[xylosyl-(1->6)-glucoside]","2-Furyl methyl ketone","Tyrosine","Rigin","8-Cyclopentyl-1,3-dimethylxanthine","Homoarginine","Ile-Leu","Acetylcarnitine (Car(2:0))","Dimethylmalonic acid","12-Methyltridecanoic acid","BENZYL CINNAMATE","Benserazide","Withaperuvin_F","Anisodamine","Hydroxychloroquine","Austalide_G","Myristic acid","Arabitol","Silibinin","Hypoxanthine","2,4-Dinitrophenol","NPC","10-Formyl-7,8-dihydrofolic acid","4-Hydroxyestrone","gamma-Linolenic acid","Hippuric acid","alpha-Solanine","alpha-Linolenic acid","LysoPC(0:0/18:0)","[8-[2-(3-methylbutanoyloxy)propan-2-yl]-2-oxo-8,9-dihydrofuro[2,3-h]chromen-9-yl] (Z)-2-methylbut-2-enoate","Butylate","LPE(18:1(9Z)/0:0)","N-Acetylaspartylglutamate (NAAG)","beta-Guanidinopropionic acid","7-[(6-hydroxy-5,5,8a-trimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl)methoxy]chromen-2-one","Phe-Asp","6,7-Dihydro-2-methyl-5H-cyclopenta[b]pyrazine","3-Aminopiperidine-2,6-dione","PS(20:0/22:2(13Z,16Z))","Gly-Ala","5-Hydroxyindole","2-Hydroxybutyric acid","gamma-Glutamyllysine","Lucidenic_acid_B","Threoninyl-Proline","Cycluron","Phe-Tyr","y-Morphine","2,4-Diamino-6-hydroxypyrimidine","2-Ethyl-2-hydroxybutyric acid","Tropine","Cinncassiol_A_19-glucoside","Adenine","Homocitrulline","Hematoporphyrin_I","Prochlorperazine","Timonacic","Gly-Phe","Capsi-amide","6-Methoxymusizin_8-O-[b-D-glucopyranosyl-(1->6)-b-D-glucopyranosyl-(1->3)-b-D-glucopyranosyl-(1->6)-b-D-glucopyranoside]","Lucidenic_acid_K","Inosine","Purine","Glycine, N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-","2-Arachidonoyl-1-stearoyl-sn-glycero-3-phosphoethanolamine","2-Hydroxyclomipramine","Cynaroside_A","Phyllanthusol_B","Diflubenzuron","Levonordefrin","Finasteride","Promethazine","N2-(2-Carboxymethyl-2-hydroxysuccinoyl)arginine","Ouabain","Physagulin_A","N-Acetyl-asparagine","Leu-Ile","LPC(18:2/0:0)","Histidinol","Ala-Gly","N-Acetylmethionine","PC(P-16:0/0:0)","3-AMINO-2-PIPERIDONE","Melibiose","Ala-Glu","Cellobiose","Cadabicine","Anserine","Lys-Glu","(3b,4b,11b,14b)-11-Ethoxy-3,4-epoxy-14-hydroxy-12-cyathen-15-al_14-xyloside","Monoethyl_carbonate","Ethylmalonic acid","Arg-Met","Pantethine","Cafamarine","Lys-Gln","Hovenidulcioside_A1","Alizapride","Ala-Gln","(R)-2-Hydroxysterculic_acid","Linezolid (Drug)","Acetylleucine","11-hydroxy-9-(hydroxymethyl)-2-methoxycarbonyl-2,6a,6b,9,12a-pentamethyl-10-(3,4,5-trihydroxyoxan-2-yl)oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid","2-Aminopyridine","Cyclo(-L-Trp-L-Tyr)","Flibanserin","Fusarochromanone","3'-N'-Acetylfusarochromanone","Dexrazoxane","4-Hydroxybenzoic acid","Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-","Aconine","Maltotriose","Diltiazem","Valproic acid","Ethyl 4-methyl-5-[(propan-2-yl)oxy]-9H-pyrido[3,4-b]indole-3-carboxylate","1-(5-Deoxypentofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione","Postin","N5-acetyl-l-ornithine","Dihydrouracil","Ranitidine","N-Acetylhistamine","Methyldopa","Nicotinamide","L-Valyl-L-phenylalanine","Tigecycline","Theophylline","Tryptophanamide","Ferulic acid 4-O-glucuronide","ETHOPROPAZINE","Glycyl-L-tyrosine","Castamollissin","Lys-Thr","Arg-Gly-Asp","(S)-Verimol_F","Succinic acid N,N-dimethylhydrazide","PE(18:0/18:2)","Octopamine, N-feruloyl-","Dorsomorphin","Oxytetracycline","Fumonisin_A1","PIP(16:2(9Z,12Z)/18:0)","7-Methoxy-1,2,3,4-tetrahydroacridin-9-amine","7-[2,6-dimethyl-8-(2-methylbutanoyloxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid","myo-Inositol","Astragalin","Pyroglutamic acid","Glucose 1-phosphate","Uridine 5'-diphosphate (UDP)","Picropodophyllotoxin","17.beta.-Estradiol 3-.beta.-D-glucuronide","Perphenazine","Glucosamine 6-phosphate","Biochanin A","N-Methylnicotinamide","Rilmenidine","Nisoldipine","5-O-Desmethyldonepezil","Isomaltose","pomiferin","Cincassiol_B","6-Aminonicotinamide","4-Hydroxybenzyl cyanide","Rhazidigenine_Nb-oxide","N-2-[4-(3,3-Dimethylallyloxy)phenyl]ethylcinnamide","Streptomycin A","Pentosidine","Deoxyguanosine","Purothionin_AII","Nylidrin","Quinic acid","Allixin","Tauro-beta-muricholic acid","Camptothecin","Valerylcarnitine","Bambuterol","Lactate","3,3',4,5'-Tetrahydroxy-trans-stilbene",".beta.-Hydroxyphenylalanine","6-Ketoestriol","Thymidine","Labetalol","2-Hydroxyhexanoic acid","Vitexin","PC(22:4(7Z,10Z,13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","Cucurbitacin_B","Isocaproic acid","Val-Ser","N2,N4-Bis(2-methoxyethyl)-2,4-pyridinedicarboxamide","Paprazine","Mizolastine_(Mizollen)","(7'R,8'R)-4,7'-Epoxy-3',5-dimethoxy-4',9,9'-lignanetriol_9'-glucoside","N-Tigloylglycine","Malic acid","3-Phosphoglyceric acid","LSD","Docebenone","Arjunolic_acid_3-glucoside","Tanshinone I","Piberaline","Arbutamine","Secologanin","[2-[docosa-7.10.13.16-tetraenoyloxy]-3-(octadecanoyloxy)propoxy]({[2.3.4.5.6-pentahydroxycyclohexyl]oxy})phosphinic acid","Prenyl-L-cysteine","Halopemide","Mandelic acid","Erucamide","Quinupristin","Canthaxanthin (Euglenanone)","Sonchuionoside_C","Maltose","LysoPC(22:2(13Z,16Z))","Theanine","3-Methyl-3H-imidazo[4,5-f]quinoxalin-2-amine","O-Desmethylcarvedilol","Gln-Met","Histamine","3-Hydorxy-3-methylglutaric acid","3-Furanmethanol_glucoside","N-Nervonoyl-D-erythro-sphingosylphosphorylcholine","N-Acetyltyrosine","Betamethasone dipropionate","(2-aminoethoxy)[2-[hexadec-9-enoyloxy]-3-[octadeca-1.11-dien-1-yloxy]propoxy]phosphinic acid","Furcelleran","Oxypurinol","Yangonin","6S,9R-Dihydroxy-4,7E-megastigmadien-3-one_9-[apiosyl-(1->6)-glucoside]","Unshuoside_A","N-Methyl-D-aspartic acid","5'-Deoxyadenosine","Torasemide","12-Hydroxystearic acid","DTyr-Val-Gly","2-Piperidone","Diglycine","Risedronic_acid","DIMBOA + O-Hex","Koenigine","Methionine sulfoxide","1-(2H-1,3-Benzodioxol-5-yl)-2-[2,6-dimethoxy-4-(prop-2-en-1-yl)phenoxy]propyl_benzoate","Normetanephrine","S-Ethyl dipropylthiocarbamate","SM(d18:1/22:0)","Prolyl-Threonine","Flunarizine","Raffinose","4-Aminobutyric acid (GABA)","Fluvoxamine_maleate","LTD4","Pyrrolidine","(6beta,7alpha,12beta,13beta)-7-Hydroxy-11,16-dioxo-8,14-apianadien-22,6-olide","PE(22:2(13Z,16Z)/P-16:0)","Mefloquine","HT-2 Toxin","Lyciumoside_VIII","Isopentenyladenosine","L-?Leucyl-?L-?alanine","Scorzonoside","Vindesine","PE(P-18:1(9Z)/18:1(9Z))","Nicotinate","N2-Maltulosylarginine","Tolterodine","Pyro-L-glutaminyl-L-glutamine","Vesnarinone","Hydroxytyrosol","Psoralen","epiyangambin","Phe-Ala","LTC4","Lercanidipine"],"additional_accession":[]},"is_claimable":false,"name":"Astaxanthin Protects Against Ferroptosis and Oxidative Stress via Retinoic Acid-Mediated SLC7A11 Regulation by Lepagella muris","description":"Oxidative stress and ferroptosis are central to the pathogenesis of many diseases, including those characterized by intestinal damage, where excessive lipid peroxidation and iron accumulation trigger cellular dysfunction. In this study, we investigate the protective effects of astaxanthin (ASTA), a potent antioxidant carotenoid, against dexamethasone (DEX)-induced oxidative stress and ferroptosis in the intestine. We demonstrate that ASTA supplementation significantly restores antioxidant defenses, enhancing key antioxidant enzymes. Furthermore, ASTA alleviates ferroptosis by upregulating GPX4 expression and reducing iron accumulation, thereby mitigating cellular damage. Using 16S rRNA sequencing and metagenomic analysis, we identify shifts in gut microbiota composition induced by ASTA, with a notable enrichment of Lepagella muris and other beneficial bacteria. These shifts correlate with the upregulation of retinol metabolism pathways, particularly those involving enzymes such as β-carotene monooxygenase 1 (BCMO1) and aldehyde dehydrogenase (ALDH). Metabolomic profiling further confirms that L. muris metabolizes ASTA to promote retinoic acid biosynthesis, which targets key ferroptosis-related genes, including SLC7A11, thereby inhibiting the activation of the ferroptosis pathway. RETINOIC ACID-mediated activation of SLC7A11 restores cellular redox balance, protecting against ferroptosis. Our findings provide mechanistic insights into how ASTA, through gut microbiota-mediated retinoic acid biosynthesis, modulates oxidative stress and ferroptosis pathways, offering a novel therapeutic approach for diseases associated with these processes. These results underscore the potential of microbiota-targeted interventions to enhance the efficacy of antioxidant therapies in treating oxidative stress-induced disorders.
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