MetaboLights

application/xml

ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13140/m_MTBLS13140_LC-MS_negative_hilic_metabolite_profiling_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13140/m_MTBLS13140_LC-MS_positive_hilic_metabolite_profiling_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13140/a_MTBLS13140_LC-MS_positive_hilic_metabolite_profiling.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13140/a_MTBLS13140_LC-MS_negative_hilic_metabolite_profiling.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13140/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13140/s_MTBLS13140.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13140 In order to visualize group separation and find significantly changed metabolites, supervised orthogonal projections to latent structuresdiscriminate analysis (OPLS-DA) was applied. Then, a 7-fold cross validation was performed to calculate the value of R2 and Q2. R2 indicates how well the variation of a variable is explained and Q2 means how well a variable could be predicted. To check the robustness and predictive ability of the OPLS-DA model, a 200 times permutations was further conducted. Afterward, the R2 and Q2 intercept values were obtained. Here, the intercept value of Q2 represents the robustness of the model, the risk of overfitting and the reliability of the model, which will be the smaller the better. Furthermore, the value of variable importance in the projection (VIP) of the first principal component in OPLS-DA analysis was obtained. It summarizes the contribution of each variable to the model. The metabolites with VIP>1 and p<0.05 (student t test) were considered as significantly changed metabolites. In addition, commercial databases including KEGG (http://www.genome.jp/kegg/) and MetaboAnalyst (http://www.metaboanalyst.ca/) were used for pathway enrichment analysisMetaboLightsPublicLiquid Chromatography MS - positive - HILICLiquid Chromatography MS - negative - HILICFor polar metabolites, LC-MS/MS analyses were performed using an UHPLC system (Vanquish, Thermo Fisher Scientific) with a Waters ACQUITY UPLC BEH Amide (2.1 mm × 50 mm, 1.7 μm) coupled to Orbitrap Exploris 120 mass spectrometer (Orbitrap MS, Thermo). The mobile phase consisted of 25 mmol/L ammonium acetate and 25 ammonia hydroxide in water (A) and acetonitrile (B). The auto-sampler temperature was 4 , and the injection volume was 2 μL. The Orbitrap Exploris 120 mass spectrometer was used for its ability to acquire MS/MS spectra on information-dependent acquisition (IDA) mode in the control of the acquisition software (Xcalibur, Thermo). In this mode, the acquisition software continuously evaluates the full scan MS spectrum. The ESI source conditions were set as following: sheath gas flow rate as 50 Arb, Aux gas flow rate as 15 Arb, capillarytemperature 320 , full MS resolution as 60000, MS/MS resolution as 15000, collision energy: SNCE 20/30/40, spray voltage as 3.8 kV (positive) or -3.4 kV (negative), respectively.Astaxanthin Protects Against Ferroptosis and Oxidative Stress via Retinoic Acid-Mediated SLC7A11 Regulation by Lepagella muris.Peking UniversityDuo KeaiBacterial liquid culture mediumSupernatant of the bacterial liquidmass spectrometrySamples were extracted for metabolites by using the Starlidworkstation. The 50 ul sample was mixed with 200 ul of extraction solution(methanol:acetonitrile=1:1 (v/v), including internal standards), shaken at 750 rpm for 5 min and settled down for 5 min, then filtered through a protein precipitation plate and the filtrate was collected. The quality control (QC) sample was prepared by mixing an equal aliquot of the filtered liquid of samplesMuribaculum?intestinaleLepagella?murisMuribaculum?gordoncarteriBacterial liquid culture mediumhttps://www.ebi.ac.uk/metabolights/MTBLS13140shuqi liu. Zhejiang University. 22317016@zju.edu.cn.The raw data were converted to the mzXML format using ProteoWizard and processed with an in-house program. which was developed using R and based on XCMS, for feature detection, extraction, alignment, and integration. The R package and the BiotreeDB (V3.0) were applied in metabolite identification.Groupkeaiduoduo998@126.comMix 100μl of bacteria at a concentration of 22 - 550 × 100000 CFU/mL with 100μl of astaxanthin at a concentration of 15 μg/ml. Incubate under anaerobic conditions at 37°C for 24 hours. The medium containing only astaxanthin is defined as the blank control. Conduct metabolomic assays on the entire culture and the blank control.MetabolomicsRetinoic AcidAstaxanthinFerroptosisRetinoic AcidAstaxanthinFerroptosisFor polar metabolites, LC-MS/MS analyses were performed using an UHPLC system (Vanquish, Thermo Fisher Scientific) with a Waters ACQUITY UPLC BEH Amide (2.1 mm × 50 mm, 1.7 μm) coupled to Orbitrap Exploris 120 mass spectrometer (Orbitrap MS, Thermo). The mobile phase consisted of 25 mmol/L ammonium acetate and 25 ammonia hydroxide in water (A) and acetonitrile (B). The auto-sampler temperature was 4 , and the injection volume was 2 μL. The Orbitrap Exploris 120 mass spectrometer was used for its ability to acquire MS/MS spectra on information-dependent acquisition (IDA) mode in the control of the acquisition software (Xcalibur, Thermo). In this mode, the acquisition software continuously evaluates the full scan MS spectrum. The ESI source conditions were set as following: sheath gas flow rate as 50 Arb, Aux gas flow rate as 15 Arb, capillarytemperature 320 , full MS resolution as 60000, MS/MS resolution as 15000, collision energy: SNCE 20/30/40, spray voltage as 3.8 kV (positive) or -3.4 kV (negative), respectively.Saikosaponin D2,5-Di-tert-butylhydroquinoneCaprolactamPyrocatecholMalonyl-L-carnitineNonanoyl-CoAPhe-Ile2-Keto-3-deoxygluconic acid2-Methylnicotinamide4-Cresol sulfate4-MethoxylonchocarpinCycloateVal-MetNolatrexed1-Octen-3-yl_primeverosideGoralatide (acetate)4-Methoxybenzyl_O-(2-sulfoglucoside)L-Erythrulose5-Hydroxymethyl-2-furancarboxylic acidN-Nitrosoproline4-Methoxy-3-geranylgeranyl-1,2-dihydroxybenzeneNorphenylephrineKetoleucineNormorphineTacrineAnhydrocinnzeylanineCaplaminCoumatetralyl2,2',4,4'-TetrahydroxybenzophenoneCitrullineGlycolateD-Erythronic acid .gamma.-lactone1,5-NaphthalenediamineClomipramine (hydrochloride)jugloneCapric acidAPGPR_EnterostatinPS(14:0/15:0)LofepramineMITOMYCIN C1-Hydroxy-2-naphthoic acidItoprideAcridine Orange17-phenyl-trinor-PGE2cis-?9,?10-?Epoxystearic acid2-Acetamido-3-(4-hydroxy-3-methoxyphenyl)propanoic acidGly-Pro-Arg4-HydroxybenzaldehydeN2-AcetylornithineN-Methylcalystegine_B2Perfluoroheptanoic acid1-DesulfoyessotoxinCholic acid 3-glucuronideTiaprideHydroxyprolyl-Isoleucine2-Methoxy-3,5-dimethylpyrazineLicoricesaponin G25-CarbolineDemethoxycurcuminTrimellitic acid anhydrideGamma-glutamyl-GlutamineMevalonic acid2-Hydroxymethyl benzoic acidArginineN,N'-Bis(gamma-glutamyl)cystineSecobarbitalDihydroxyfumitremorgin_CEthyl_cellulose[3-[octadec-11-enoyloxy]-2-(octadecanoyloxy)propoxy]phosphonic acidSer-Gly(+)Catechin4-Hydroxyglutamic acidLysoPC(18:4(6Z,9Z,12Z,15Z))Corchoroside_BCyproterone_acetateCyclopassifloside_VIIOxiracetam5-HydroxylysinePiperonylic acidTetrabenazineThaumatin_b,_recombinantCinncassiol_C1_19-glucoside4-Methyl-5-thiazoleethanolN6-MethyladeninePro-GlyMethylergonovinePyridoxal (Vitamin B6)IsradipineVomifoliol_9-[glucosyl-(1->4)-xylosyl-(1->6)-glucoside]Kainic acidN-Methyl-L-prolineN-Acetylneuraminic acidPantothenic acidGln-ProGenistein-4'-glucuronideYohimbine7H-Benzo[de]anthracen-7-oneRitonavirOmeprazole sulfone1-Hexanol_arabinosylglucosidePhe-GlnPhenylalanine betaineErgometrineLeu-Val1-O-Hexadecyl-sn-glycero-3-phosphocholine (LPC(O-16:0/0:0))Xanthurenic acidSaquinavirMetaproterenol1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamineMet-GlyAcetylglycineProcyclidine2-Oleoyl-1-stearoyl-sn-glycero-3-phosphoserineHEPTANOIC ACIDPhe-GlyNorophthalmic_acidPhe-GluTorvoside_GMethanone, (4-ethyl-1-naphthalenyl)[1-(5-fluoropentyl)-1H-indol-3-yl]-Rucaparib25-AcetylvulgarosideDiethylthiophosphateMupirocinProlylalanineCorchoionoside_Balclometasone_dipropionate2-Phenyllactic acidMethylguanidine(2-aminoethoxy)[3-(hexadecanoyloxy)-2-[icosa-5.8.11.14-tetraenoyloxy]propoxy]phosphinic acidAsparaginyl-ValineOrnithine2-amino-3-({hydroxy[2-(icosanoyloxy)-3-[octadec-11-enoyloxy]propoxy]phosphoryl}oxy)propanoic acid4-Acetamidobutyric acid3-MethyladeninePS(18:0/18:2)3-Hydroxybenzoic acidarctiinIbotenic acidCarbidopaN-PhenylacetamideIsoniazid (Drug)SerineArg-ProNorsufentanil8-ShogaolS-Allyl-L-CysteinePisumoside_ADiazinon(Phenoxymethyl)penicilloic acidPromethazine sulfoxidePhe-ThrPhenylsulfate7,11,12-TriacetoxycoumestanAsp-GluTyr-GlyMelphalan.alpha.,.alpha.'-Trehalose 6-phosphate2,4-Diamino-6,7-dimethoxyquinazolineCinnzeylanineLPC(18:1)Valylphenylalanine2-[4-(4-Chloro-1,2-diphenyl-1-buten-1-yl)phenoxy]-N,N-dimethylethanamineAdenosinePC(16:0/18:1(9Z))Methyl acetoacetateAllopurinolPIP(16:1(9Z)/18:0)2-Oxovaleric_acid_(S)-Cotinine N-oxideGlycinoeclepin_CPro-Ile2-Hydroxycinnamic acidL-tyrosine-methyl-esterLinoleic acidPC(18:0/18:3(6Z,9Z,12Z))CilostamidePropanoic acid, 3-[[[4-[4-[[[1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3- methyl-5-isoxazolyl]phenyl]methyl]thio]-TacrolimusGanoderic_acid_MiBenazeprilArg-AspLIMONINArg-AsnPC(18:0/18:1(9Z))5-Amino-4-carbamoylimidazole (AICA)TriamcinolonePS(14:0/14:1(9Z))O-Methyl-DL-serineTri(butoxyethyl)phosphate2-Amino-3-(1H-pyrazol-1-yl)propanoic acidBetonicineBenzoic acidDaidzinCandesartan5-MethylcytosinePC(15:0/P-18:0)ArgatrobanMethylsuccinic acidTrp-GlykaranjinGlycolithocholic acid 3-sulfateThr-SerDalfopristinO-Acetylserine3'-O-MethylguanosineMerodesmosine5-(N-Ethyl-N-isopropyl)amiloridePA(20:4(5Z,8Z,11Z,14Z)/20:3(8Z,11Z,14Z))5-HydroxymethylfurfuralFerulic_acid_4-sulfateL-AcetopineSphingosine(2R)-6-Oxo-2-piperidinecarboxylic acidChlorhexidine1-Hydroxy-3,5-dimethoxy-2,4-diprenylxanthoneL-3-Aminoisobutyric acid1,2-Distearoyl-sn-glycero-3-phospho-L-serine6-Formylpteringamma-Glutamylleucine4-Imidazolidineheptanoic acid, 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-2-Ketobutyric acid(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoateLys-LeuN-Acetyl-arginineBortezomib__Kaempferol 3-ss-D-galactosideTelmisartanTiglic_acidParacetamol (Drug)Valeric acidHis-SerGibberellic_AcidNitrofurazoneLysineSM(d18:1/17:0)CyclobenzaprineS-(2-Hydroxyethyl)glutathioneButyllactateThymol blueHexobarbitalTrehalosePro-Gly-Pro2-Methylbutyrylglycinealpha-Ketoglutaric acid (alpha-KG)(3xi,6xi)-Cyclo(alanylvalyl)Lys-Asp5-Amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidTalbutalLys-Asn2-O-Methylcytosine2'-AminoacetophenoneBetanidinDihydro-6-isopropyl-2,4-dimethyl-4H-1,3,5-dithiazineGuanineSM(d18:0/18:0)7-HydroxyamoxapineCorynanthinEthyl 3-(N-butylacetamido)propionate3'-Hydroxy-T2_ToxinSECO-ISOLARICIRESINOL_DIGLUCOSIDEN-AcetylphenylalanineBursinAcetic acid, 2-[[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-Cytidine 5'-monophosphate (CMP)1,2,3,4-Tetrahydro-2-methyl-b-carbolineTaraxinic_acid_glucosyl_esterAnnoglabasin_CGlu-ValXanthosineIsoxabenPerseitolCysteine-glutathione disulfideDigitoxigenin_3-[glucosyl-(1->6)-glucosyl-(1->4)-2,6-dideoxyribohexoside]3-Methyl-2-oxovaleric acid4-HydroxytriamtereneMannose 1-phosphateGlycylleucineN'-Nitrosonornicotine7-MethylguanineNicardipineAla-Argcis-9-Palmitoleic acidPefloxacinSsiorisideMonomethyl phthalateEvobiosideCytidine 5'-diphosphate (CDP)Hydroxyisocaproic acidGlabrolMepirizoleLysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z))MilrinonePravastatinInosine 5'-monophosphate (IMP)Phe-ValPipecolic acidpapaverinep-CoumaroylputrescineRanolazineProlyl-SerinePteroside_BGlucose 6-phosphateLys-Pro2'-DeoxyuridineIndole-3-carboxaldehydeAla-ProStachyoseStearic acidOrotidinePI(20:1(11Z)/20:4(8Z,11Z,14Z,17Z))Ethynodiol_diacetate2-Ethylpyrazine1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1'-myo-inositol)Cinncassiol_EEthyl 4-hydroxybenzoateVelcorinDipiperamide_DDipiperamide_CDipiperamide_AMometasone_furoateAla-AspGlutamateCinncassiol_ASuccinic_anhydrideCalycinCarnitineHydroquinoneCreatine, ethyl esterAcuminosideN1,N5,N10-Tris-trans-p-coumaroylspermineDG(24:0/22:1(13Z)/0:0)RU-02117,8-Dihydro-3b,6a-dihydroxy-alpha-ionol_9-glucosideZolpidemAmericinePC(P-16:0/18:4(6Z,9Z,12Z,15Z))GivinostatDL-Isocitric acid lactoneGarcinone CLPC(16:0)Pteroside_Z3-Benzoyloxy-11-oxo-12-ursen-28-oic_acidLenalidomide__GenisteinBazedoxifeneIsophysalin_G5-HydroxykynurenineVardenafilAlanylalanine (Ala-Ala)CinitaprideTejedineb-Ala-LysPC(20:4(8Z,11Z,14Z,17Z)/15:0)1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholineAllysineAcetic acid, 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-Isobutyrylcarnitine (Car(4:0))3-ketosphinganineN6,N6,N6-Trimethyllysine3-[(5-Oxo-2-pyrrolidinyl)carbonyl]-1,3-thiazolidine-4-carboxylic acid(3E)-4-(1-Hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl)but-3-en-2-yl 6-O-pentopyranosylhexopyranoside2,4,6-TrimethylpyridineHis-Lys(2-aminoethoxy)[2-[octadec-9-enoyloxy]-3-[octadeca-1.11-dien-1-yloxy]propoxy]phosphinic acidPiperolein API(16:0/18:1)GramineN-BenzyladenineAcetyl tributyl citrateThymine2-Acetamidooctanoic acid1-HydroxyalprazolamIsocyclomorusinPelargonic acid2-Hydroxyglutaric acid1-MethyladenosineTamsulosinKoryoginsenoside_R1Harmaline_hydrochloride_dihydrateN-Acetylglucosamine 1-phosphateTOBRAMYCINschisandrin BPropanedinitrile, 2-[(3,4,5-trihydroxyphenyl)methylene]-Asn-Gly4-HydroxyisoleucineDihydroorotic acidMaltolSarcosine4-Hydroxyphenylacetic acidSinomenineDihydroneopterin_phosphate1-(2-Pyrimidyl)piperazineVinaginsenoside_R142-(1-Propenyl)-delta1-piperideineTaurineN-AcetylgalactosamineN-Acetyl-2-carboxybenzenesulfonamide((6-O-Hexopyranosylhexopyranosyl)oxy)(phenyl)acetonitrileZalcitabineHistidylproline diketopiperazine2,3-Dihydroxy-3-methylbutyric acid2-Aminonicotinic acidO-PhosphoethanolamineOchratoxin APipercyclobutanamide_BAdluponeMaltobionateTrospiumkaempferol 7-neohesperidosideGly-Pro-GluTrifluoroacetic acidPirbuterol[2-(4-Aminofurazan-3-yl)-1-ethylimidazo[4,5-c]pyridin-7-yl]methyl-(4-piperidyl)amine3-PhosphoserineTrimethobenzamideIchangin_4-glucosideTicagrelorD-GlucosaminidePiperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-Sph(d18:0)Carbamoyl_phosphateTrigonelline2-Carboxy-1-[5-(2-carboxy-1-pyrrolidinyl)-2-hydroxy-2,4-pentadienylidene]pyrrolidinium(.+/-.)-DropropizineDiclofensine8-Hydroxyguanosine5-Hydroxymethyltolterodine1,1'-EthylidenebistryptophanRetinoic acid (Vitamin A acid)Diacerein3,3',5'-Triiodo-L-thyroninePentoxifylline2-PhenylethynesulfonamidePrometonIsovalerylglutamic_acidPC(18:1(11Z)/15:0)DiphacinoneEnalaprilat (dihydrate)trans-Vaccenic acidIsoleucylvalineDabigatran_etexilateS-(PGA1)-glutathione1-MethylguanosineTroglitazonePC(18:1(9Z)/P-16:0)N-nornuciferineFerrioxamine_B_[M+Fe-2H]LoperamideTopiramateOleanane -2H, +1O, 1COOH, O-HexA-HexANotoginsenoside_R9Undecanoic acidCassythicinetrans-Aconitic acidACARBOSE2,5-DimethylpyrazineKiwiionosideRoquefortineVirolongin_B[2-[4-Methyl-2-(2-methylpropanoyloxy)phenyl]oxiran-2-yl]methyl 2-methylpropanoateFructose 1-phosphateCystineVal-Ile2-Aminobutyric acidGanoderenic_acid_E4-(Dimethylamino)pyridine4-HydroxymethylpyrazoleEbastinAtipamezoleCanesceinNigellicine(8S,8'S)-Secoisolariciresinol_9-xylosidePhenylalanineCar(18:0)Estriol-17-glucuronide3-Methyl-.gamma.-butyrolactoneProlylhydroxyprolineBiotin sulfonePyrogallolPentaethylene glycolpibutidineBenzamidine (hydrochloride)DofetilideEremopetasitenin_B2UracilMyosmineTetradecenedioylcarnitine (Car(14:1-O2))MeclozineQuinaprilCRUSTECDYSONECrotonic acidTryptamineTrp-TrpPhloroglucinolAmisulpridePromazineCreatine5-Aminolevulinic acidCaprylic acidMaravirocS-Furanopetasitin4-Methylbenzoic-acidSM(d18:1/18:0)PA(20:5(5Z,8Z,11Z,14Z,17Z)/20:4(5Z,8Z,11Z,14Z))FuranylfentanylCytosineRisperidoneAsp-AspKuwanon CPro-PheN-AcetylsulfamethoxazoleN6-MethyladenosineHarderoporphyrinogen4-Acetamido-2-amino-6-nitrotolueneTolazoline (hydrochloride)N2,N2-DimethylguanosineBisoprololGuanidinosuccinic acid7,8-DihydroxyflavoneN2-(1-Oxo-4-phenylbutyl)-L-glutamineDoramapimodDiflufenicanTryptophyl-MethionineOxalic acidCarvedilolN,N-Dimethylarginine (ADMA)Tyr-ArgBeclomethasone dipropionateTaraxacolide_1-O-b-D-glucopyranosideSR2714253,4-DihydroxymethamphetaminePehanormTriacetyl resveratrol4'-Methylliquiritigenin_7-rhamnosidePE(P-36:4)Kuwanon_L(3b,20R,22R)-3,20,27-Trihydroxy-1-oxowitha-5,24-dienolide_3-glucosideCyclanilidePimozideO-DesmethylastemizoleVal-Val(2S)-4-amino-2-[(azaniumylacetyl)amino]-4-oxobutanoateRetrocalaminGln-ThrApigenin 7-glucosideLPC(18:0/0:0)HomocarnosinePA(18:4(6Z,9Z,12Z,15Z)/18:4(6Z,9Z,12Z,15Z))ChromocarbUDP-N-acetylglucosamineOlmesartanSer-Pro5,7-Dihydroxy-6-methoxyflavone_5-rhamnosidePesticide4_Boscalid_C18H12Cl2N2O_3-Pyridinecarboxamide, 2-chloro-N-(4'-chloro[1,1'-biphenyl]-2-yl)-9,10-Dihydro-2,3,5,7-PhenanthrenetetrolO-b-D-Gal-(1->3)-O-[O-b-D-Gal-(1->4)-2-(acetylamino)-2-deoxy-b-D-Glc-(1->6)]-2-(acetylamino)-2-deoxy-_D-Galactose8-Oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl hexopyranosidePiperanineIsoleucine2-Methyl-3-hydroxybutyric acid2-Phenylethyl 6-O-pentopyranosylhexopyranosideCyanidin-3-glucoside2,5-Dimethyl-3-(1-propenyl)pyrazineArachidonic acid (AA)Canrenone2-Methylhippuric acidPyruvateLys-MetThreonic acidCanertinibLysoPC(18:3(6Z,9Z,12Z))2,2'-Iminodiacetic acidMyristicanol_AHeptadecanoic acidDoxycyclineCitraconic acidRepaglinide1-Deoxy-D-glucitolAmobarbitalArg-ThrRifaximinNorepinephrineCytidine 5'-diphosphocholine (CDP-choline)Dimethylglycine1-O-trans-cinnamoyl-beta-D-glucopyranose3-Hydroxyphenylacetic acidGlutamine1,2-Dimethylimidazole5-Amino-6-ribitylamino uracilCymorcin_diglucosideDarunavirPhenylacetic acidCaproic acidPE(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)Dihydroxyacetone phosphatePalmitic acidsn-Glycerol 3-phosphateSucrose_acetate_isobutyrate1,3-Bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ureaHistidineBenzamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-ConvallatoxinCanesceol4-Hydroxycinnamic acidSaccharopineInositol_cyclic_phosphateclemastineValtratumTyramineIsoamylamineArg-Pro-ProAllopurinol-1-ribonucleosidePhenylbutazone1-alpha-AcevaltrateAmlexanoxGlycyl-glutamatePropionylcarnitine (Car(3:0))Gly-ValDeoxyadenosine20-hydroxy-LTE4PergolideIsopetasosideSer-AlaPrednicarbatepiritramideIsobutyric_acidLysoPE(24:6(6Z,9Z,12Z,15Z,18Z,21Z)/0:0)BifemelaneGlycerophosphocholineAzetidine-2-carboxylic acidGlimepirideOlitoriusinNorisodomesticineAmikacinPhysalin_LRosoxacinMLS001148159-01!METHYLPREDNISOLONE1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-.alpha.,.alpha.- dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acidThr-LeuBetavulgaroside_VIIThiethylperazineHydrocortamateIndoleacetic acidDesbenzyl donepezil3-Pyridylacetic acidN-Methylglutamic acidEdaravoneAcadesine (Drug)Presqualene_diphosphateHydroxyphenyllactic acidBenzamide, N-[2-(dimethylamino)ethyl]-N-methyl-4-[[[[4-[4-(4-morpholinyl)-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl]amino]carbonyl]amino]-N-LactoylphenylalanineL-Alanyl-L-leucinePC(P-18:0/18:1(9Z))Alanine2-Methylguanosinegamma-GlutamylglutaminePhosphoenolpyruvic acidLevulinic acid3-PyridinecarboxaldehydeCodeine-6-.beta.-D-glucuronideN-AcetylputrescineTryptophanFluvoxamine_acidFalcarinoloneXanthineDesmethylverapamilFructose 6-phosphateNobiletinHis-LeuPhysoperuvinePC(16:0/20:4)CholineAsparagineSchizandrin(10E,15Z)-9,12,13-Trihydroxyoctadeca-10,15-dienoic acid2-Anilinopropanoic acidLeucylphenylalanine(1R,3R,4R,5S,6S,8x)-1-Acetoxy-8-angeloyloxy-3,4-epoxy-5-hydroxy-7(14),10-bisaboladien-2-oneBetamethasone-17-valerate(Sulfanylsulfonyl)methane(8R,8'R)-Secoisolariciresinol_9-glucosidePG(16:0/18:1)Arg-Phe1-isothiocyanato-8-methanesulfinyloctaneGymnodimineSesaminAnilineIsopalmitic_acidAdenosine monophosphate (AMP)MethylhalfordinolPhenylpropionylglycineLopinavir_(ABT-378)IsobutyrylglycineAla-Lyso-TyrosineCinnamoside2-Aminopurine3-Amino-4-methylpentanoic acidIndoxyl sulfateDocetaxelGalactaric acidtrifolirhizinCytidine 2',3'-cyclic phosphatePhosphorylcholine2-[4,6-Bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl]-5-(octyloxy)phenola-L-Fucopyranosyl-(1->2)-b-D-galactopyranosyl-(1->2)-D-xyloseVal-GlyPE-NMe2(14:0/14:0)[U]2,4-DihydroxybenzophenoneErlotinib2-Hydroxy-2-methylbutyric acidQuinidineDimethyl sulfoxideZON(-)-trans-4-[4-(4'-Fluorophenyl)-3-piperidinylmethoxy]-2-methoxyphenolMildronateProtoporphyrin IXPyruvaldehydeRifapentineMethysergide3'-Hydroxystanozolol1H-Indazole-4-carboxamide, N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-5-HydroxyoxindoleThr-ProColistinNitrazepamRolitetracyclinePA(18:4(6Z,9Z,12Z,15Z)/18:2(9Z,12Z))LeucineCHES4-Hydroxyphenylpyruvic acidIcariside_E5MaltoheptaosePA(20:5(5Z,8Z,11Z,14Z,17Z)/15:0)PiperidinePro-ProArg-Ala(3-Aminopropyl)(diethoxymethyl)phosphinic acid2-Stearyl_citrateAtazanavirHis-ProIndolmycinDethiobiotinMaltohexaoseRosmaricine7-HydroxyfluphenazineAlpha-TrisaccharidePhenoxybenzamineThr-CysIrinotecan11,12,14-Trihydroxy-7-methoxy-8,11,13-abietatrien-20,6-olideCorolosideVanillinEnzastaurin2'-Deoxyguanosine 5'-monophosphate (dGMP)PC(18:2(9Z,12Z)/P-16:0)1,7-Dimethylxanthine5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoleThr-PheDoxazosin1-O-Octadecyl-sn-glyceryl-3-phosphorylcholineLacto-N-triose_I2'-O-MethyluridineLevetiracetam (Drug)Riboflavin1-Propanesulfonamide, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-RamiprilMeAIBProlyl-TyrosineMetyrapolDeoxyinosineAminoglutethimide3-cis-Hydroxyglipizide1,8,9-AnthracenetriolManidipine (Manyper)2-Ketocaproic acidSuccinic_acid_semialdehyde(9R,10S,12Z)-9,10-Dihydroxy-8-oxo-12-octadecenoic_acidN-AcetylvalineHexanoylglycineCediranib2-Methylbenzoic acidDimethyl hydrogen phosphateMangostineLicoricesaponin_D3Lys-ValHarman2-Methyl-4'-(methylthio)-2-morpholinopropiophenoneNitecaponeTropinoneBiotinEZETIMIBEArecoline(2S,4S)-MonatinLigustrazineOctadecanedioic acidEnoxacin (hydrate)DaphniphyllineAmpicillin(R)-5-MethylhydantoinCerP(d18:1/12:0)Divanillyltetrahydrofuran_ferulateN-Acetylaspartic acidArmillaridinMesaconic acidChemotatic PeptidePS(14:1(9Z)/20:1(11Z))L-FucitolGlucosylgalactosyl_hydroxylysineLamotrigineN-Desmethyl imatinibFlavanone base + 6OHeptane-1-thiolKanamycin ALeucyl-MethionineEriojaposide_A16:0 PE (1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine)Lauric diethanolamideArabinono-1,4-lactoneGlycineIloperidoneValyl-GlycineArg-ValOleic acidGlu-ArgCystathionineGlutaric acidDeoxypyridinolineAFN9112'-O-Methyladenosine2,6-DimethylpyrazineOlean-12-en-28-oic acid, 2,3,23-trihydroxy-, (4.alpha.)-N-Acetylglutamic acidIsolimonic_acid3-HYDROXYGLUTARIC ACIDOxibendazoleDMPOSer-SerPseudouridineButyrylcarnitine (Car(4:0))MLS001077323-01!51333-22-32-Dimethylamino-6-hydroxypurineChloropanaxydiolSecoisotetrandrineTerephthalic-AcidLuminespib1-O-Hexadecyl-2-O-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glyceryl-3-phosphorylcholineN-AcetylcadaverineOphiopogonin_CHis-ValIsolupalbigeninIfenprodilGoshonoside_F1DihydrocapsaicinPosaconazoleOctocryleneLucidenic Acid E2AminocarbTyrosylalanineIsovaleric acidGuanosine4-HydroxymephenytoinProtopineRibothymidine7-Keto-8-aminopelargonic acidGlycochenodeoxycholic_acid_3-glucuronide5-Acetylamino-6-amino-3-methyluracil (AAMU)Paradisin_CHydromorphone-3-.beta.-D-glucuronideCysteine S-sulfateClausarinolGambogic_acidD-PinitolGlu-AlaMurrayazolinolPyroGlu-Trp6,7-Didehydrofevicordin_F_3-[glucosyl-(1->6)-glucoside]BipindogulomethylosideGamma-glutamyl-GlycinePiracetamGlyceric acidAFMKLactaldehydeImatinib2-amino-3-({[3-(hexadecanoyloxy)-2-(octadecanoyloxy)propoxy](hydroxy)phosphoryl}oxy)propanoic acidisepamicinLys-IleFlavanone base + 5O2-Aminoisobutyric acidLoganintrans-ZeatinCyclohexanecarboxamide, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-PC(P-32:0)Homocitric acidHecogeninXylosePalmitoyl sphingomyelinPhosphonic acid, P-[[4-[(1-oxotetradecyl)amino]phenyl]methyl]-Bismurrayafoline_EL-Prolyl-L-leucylglycylamideL-Thyronine1-MethylguaninePyrophosphateUridinePutative Phenylalanine conjugated chenodeoxycholic acidImazamoxprednisoneN6-MethyllysineSulfaphenazole1-oleoyl-2-myristoyl-sn-glycero-3-phosphocholine4-HydroxyphenylacetaldehydeLymecyclineMalonic acidTapentadol-.beta.-D-glucuronide2-HydroxyadenineProlineAla-MetAsticolorin_BCoagulin_R_3-glucosideVilazodone6-Acetyl-2,3-dihydro-2-(hydroxymethyl)-4(1H)-pyridinoneLicoagroneAspartyl-GlycinePolysorbate_20Epicatechin gallateEpidermin3-Hydroxypropionic acid (beta-lactic acid)Methiocholic acid putativeMarimastat2-AcetamidophenolGlutarylcarnitineThr-AlaPesticide3_Carbofuran_C12H15NO3_Furadan3-Nitrotyrosine1-(2-Methyl-5-nitro-1H-imidazol-1-yl)-2-propanolGly-HisCaftaric_acidThiamineLACTULOSENelarabine__TRH, free acidN-AcetyltryptophanPhe-LysTestosterone_glucuronide2,4-Dihydroxybutanoic acidAlloseleonurine5-Nitro-2-propoxyanilineHis-IleTaxiphyllin(1xi,3S)-1,2,3,4-Tetrahydro-1-methyl-beta-carboline-1,3-dicarboxylic_acidFumaric acidN1,N10-Diferuloylspermidine3-O-p-trans-Coumaroylalphitolic_acid1-(3-carboxypropyl)-3,7-dimethylxanthineDesferrioxamine B + Al (M-2H+Al)FomepizolePhenylpyruvic acid3-Hydroxycinnamic acid4-Hydroxybenzyl_isothiocyanate_rhamnosideClarithromycinPhe-Pro1-(3,4-Diethoxybenzyl)-6,7-diethoxyisoquinolineSucrosePhenylalanylphenylalanineTrihexyphenidylDaltogenbeta-Cyano-alanineMannoseClitocineDodecyl gallateStrictosidineGlycylprolineN-[2-(4-Prenyloxyphenyl)ethyl]tiglamideDL-Threonine methyl esterArtesunateEthylsuberenol8-Isobutanoylneosolaniol2-[2-[19-acetamido-6-(3,4-dicarboxybutanoyloxy)-16,18-dihydroxy-5,9-dimethylicosan-7-yl]oxy-2-oxoethyl]butanedioic aci2-Aminonaphthalene[1-hydroxy-1-(4-methoxyphenyl)propan-2-yl] 4-methoxybenzoateCephaeline3'-O-MethyladenosineSakacin_ATaurocholic acidAflatoxin M1MethoxyfenozideDovitinibVal-ProAcetylsalvipisoneSpectinomycinMoracin_J3-METHYLGLUTACONIC ACIDRoflumilastUrocanic acidImidafenacinguanadrelDL-.alpha.-PhenylglycinePirenperoneFagomine9-HydroxyrisperidoneRiboflavine_2',3',4',5'-tetrabutanoateEgtazic acid2-AminopimelateDemecolcineIvacaftorArg-GlyN-AcetylglucosamineNefazodoneDihydroergocristineFormyl-5-hydroxykynurenamineOxaprozinTetraethylene glycol3-PyridinemethanolIsoglobotriaose5-HydroxydopamineOlmesartan medoxomilAstemizoleBenzamide, 2-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)-5'-MethylthioadenosineOxacillinHydroxyacetoneAcetophenone2-HydroxypyridineMepacrineCreatinineHis-GluPolypodoside_B3-Aminobutanoic acid2-Aminoheptanoic acidAspartateQuinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-Guanosine 5'-diphosphate (GDP)PyridoxineEmodin4-Amino-2-methyl-5-pyrimidinemethanolFormiminoglutamic acid5-Aminopentanoic acidValineStachydrineLeu-TrpHis-GlnMuramateThr-GlyActaritCanavaliosideHexaethylene glycolCis-Caffeoyl_tartaric_acidFAPy-adenineTheobromineS-(2-Carboxypropyl)glutathione3-Methoxy-4-hydroxyphenylglycol sulfateGlu-Asp5-MethyldeoxycytidineAlliospiroside_CItaconic acidLeu-Leu5-FluorouridineAcetaminophen sulfateBetaineTetraglymeN-Methylhydantoin2-Propyl-4-pyridinecarbothioamideNeoquassinEverolimusErythroskyrinNortriptylineKenposide_BTriparanol4-Hydroxy-4-(3-pyridyl)-butanoic_acidtripamideMesaconitine2-Hydroxy-3-methylbutyric acid1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholinePonatinibCytidinePipernonalinehexadecanedioic_acid_mono-L-carnitine_ester1,2,3,4-Tetrahydroisoquinoline-7-sulfonamideLeucylleucyltyrosineGlu-AsnFusarin_CCandoxatrilSuccinamidePyridostigminePS(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))Asparagoside_B5,6-Isopropylidene-L-ascorbic acidDelphinidin_3-lathyroside_5-glucosideAlfuzosinN-(2-furylmethyl)-9H-purin-6-amineH-Val-Ala-OHImazamethabenz-methylPS(22:4(7Z,10Z,13Z,16Z)/20:1(11Z))DimethylbenzimidazoleO-Methylganoderic_acid_O1,2,3-Tris(1-ethoxyethoxy)propane1-MethylhistidineDodecanoic acidIsoleucyl-ThreonineHERALENOLKukoamine_C5-HydroxyrosiglitazoneIsomorellic_acidPC(18:3(9Z,12Z,15Z)/18:1(9Z))NorethindronePhenethyl rutinosideCoumachlor(.+/-.)-MahanineSulfanilic acidPC(18:1(9Z)/18:1(9Z))Blumealactone_ARamiprilat1-(4-Hydroxy-3,5-dimethoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-3,5-heptanediolGlycerophosphoethanolamineCapsicum_annuum_Fluorescent_chlorophyll_catabolitePipotiazineGlycyl-Lysine2-Hydroxyethanesulfonic acidGly-SerMarbofloxacin2-NaphthalenethiolMethyl_7-epi-12-hydroxyjasmonate_glucosideButyl_3-O-caffeoylquinateVincristine13(S)-HODEFlavoxateCodeineHydroxyzineFluocinolone acetonideEthyl_7-epi-12-hydroxyjasmonate_glucoside4-[2-(2,6-dimethoxy-4-prop-2-enylphenoxy)-1-hydroxypropyl]-2-methoxyphenolTetraphyllin_BPentylenetetrazoleGlu-ProN-AcetylalaninePhe-HisFlunitrazepamIsonicotinic acid(S)-2-Ureidopentanedioic acidGallocatechinAllantoinEmbelinSpiroxamine2-methylcitrateBistrisLormetazepam7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine, N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-Fumitremorgin_C.beta.-D-Glucopyranosiduronic acid, 4-(7-hydroxy-4-oxo-4H-1-benzopyran-3-yl)phenylFructose 1,6-bisphosphateN2-AcetyllysineDihydroferuperineMethyl redN-Carboxyethyl-gamma-aminobutyric_acidPiperacillin4-Guanidinobutyric acid1-Hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine5-HydroxytryptophanN-Carbamoyl-2-amino-2-(4-hydroxyphenyl)acetic_acid4-Fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]phenol3-AminophenolKynurenic acidAdenosine 3'-monophosphatebeta-AlaninePhe-Trp1,2,3,6-Tetrahydropyridine-4-carboxylic acidNetilmicin1-MethylpyrrolidineBlumenol_C_O-[apiosyl-(1->6)-glucoside]EtofyllineMethionine1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-alpha-Ketoisovaleric acidSinapine(2-aminoethoxy)[3-[hexadec-1-en-1-yloxy]-2-[icosa-5.8.11.14-tetraenoyloxy]propoxy]phosphinic acid4-((3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-(((2R,4S,5S,6R)-5-(((2S,4S,5S,6R)-5-(((2S,4S,5S,6R)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-12,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-oneTrifluperidolNalbuphine9-Oxooctadecanoic acid(2-aminoethoxy)[2-[icosa-5.8.11-trienoyloxy]-3-[octadec-1-en-1-yloxy]propoxy]phosphinic acidalpha-Keto-gamma-(methylthio)butyric acid1-Methyl-3-indoleacetic acidAndrostendioneLysoPC(20:4(5Z,8Z,11Z,14Z))4-HydroxyprolineCholesteryl sulfateMethyl_helianthenoate_A_glucosideAvocadyne AcetateGabapentin4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanolCelastrolIsovalerylcarnitine (Car(5:0))Austalide Dalpha-ChaconineCarnosineUbiquinol_83-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dioneN-Formylglycinegamma-Glutamylglutamic acidNeostigmineLincomycinLinoleamideIle-ProPhosphateisoimperatorinGlycerol_trihexanoateHexamethylquercetagetinSolacauline3,5-dihydroxydecanoic acidPentadecanoic acid3-[[4-(4-Chlorophenyl)piperazino]methyl]-1H-pyrrolo[2,3-b]pyridinePS(22:2(13Z,16Z)/20:2(11Z,14Z))Kojic acidKanokoside_APenciclovirGalactinol3',5'-Cyclic guanosine monophosphate (cGMP)Pentacarboxyl_porphyrinogen_IIIBenzoic acid, 2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]-Hydroxyprolyl-ProlineGinsenoside_Rb2Guanosine 5'-monophosphate (GMP)3-Phenylpropanoic acidPS(20:5(5Z,8Z,11Z,14Z,17Z)/14:1(9Z))2-QUINOLINECARBOXYLIC ACIDPhe-LeuFlurandrenolideGlu-GlyFarnesylcysteinePipericineDG(20:5(5Z,8Z,11Z,14Z,17Z)/18:1(11Z)/0:0)Glu-GluGinsenoside_ReIle-Pro-IleIndolelactic acidNorleucineLagerstroemineRibulose 5-phosphateFusidic_acidNilutamideAprobarbitalBarbitalGossypol3-(3,4-Dihydroxyphenyl)-2-hydroxypropanoic acidLysoPE(18:4(6Z,9Z,12Z,15Z)/0:0)XanthotoxolbutabarbitalTyrosylglutamic acidMimosinepGlu-Glu-Pro-amide[3-[[2,3-dihydroxypropoxy]-hydroxyphosphoryl]oxy-2-hexadecanoyloxypropyl] hexadecanoate3-MethyluridineAminopicolinematairesinol2-Isopropyl-6-methoxypyrazineTryptophol_[xylosyl-(1->6)-glucoside]2-Furyl methyl ketoneTyrosineRigin8-Cyclopentyl-1,3-dimethylxanthineHomoarginineIle-LeuAcetylcarnitine (Car(2:0))Dimethylmalonic acid12-Methyltridecanoic acidBENZYL CINNAMATEBenserazideWithaperuvin_FAnisodamineHydroxychloroquineAustalide_GMyristic acidArabitolSilibininHypoxanthine2,4-DinitrophenolNPC10-Formyl-7,8-dihydrofolic acid4-Hydroxyestronegamma-Linolenic acidHippuric acidalpha-Solaninealpha-Linolenic acidLysoPC(0:0/18:0)[8-[2-(3-methylbutanoyloxy)propan-2-yl]-2-oxo-8,9-dihydrofuro[2,3-h]chromen-9-yl] (Z)-2-methylbut-2-enoateButylateLPE(18:1(9Z)/0:0)N-Acetylaspartylglutamate (NAAG)beta-Guanidinopropionic acid7-[(6-hydroxy-5,5,8a-trimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl)methoxy]chromen-2-onePhe-Asp6,7-Dihydro-2-methyl-5H-cyclopenta[b]pyrazine3-Aminopiperidine-2,6-dionePS(20:0/22:2(13Z,16Z))Gly-Ala5-Hydroxyindole2-Hydroxybutyric acidgamma-GlutamyllysineLucidenic_acid_BThreoninyl-ProlineCycluronPhe-Tyry-Morphine2,4-Diamino-6-hydroxypyrimidine2-Ethyl-2-hydroxybutyric acidTropineCinncassiol_A_19-glucosideAdenineHomocitrullineHematoporphyrin_IProchlorperazineTimonacicGly-PheCapsi-amide6-Methoxymusizin_8-O-[b-D-glucopyranosyl-(1->6)-b-D-glucopyranosyl-(1->3)-b-D-glucopyranosyl-(1->6)-b-D-glucopyranoside]Lucidenic_acid_KInosinePurineGlycine, N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-2-Arachidonoyl-1-stearoyl-sn-glycero-3-phosphoethanolamine2-HydroxyclomipramineCynaroside_APhyllanthusol_BDiflubenzuronLevonordefrinFinasteridePromethazineN2-(2-Carboxymethyl-2-hydroxysuccinoyl)arginineOuabainPhysagulin_AN-Acetyl-asparagineLeu-IleLPC(18:2/0:0)HistidinolAla-GlyN-AcetylmethioninePC(P-16:0/0:0)3-AMINO-2-PIPERIDONEMelibioseAla-GluCellobioseCadabicineAnserineLys-Glu(3b,4b,11b,14b)-11-Ethoxy-3,4-epoxy-14-hydroxy-12-cyathen-15-al_14-xylosideMonoethyl_carbonateEthylmalonic acidArg-MetPantethineCafamarineLys-GlnHovenidulcioside_A1AlizaprideAla-Gln(R)-2-Hydroxysterculic_acidLinezolid (Drug)Acetylleucine11-hydroxy-9-(hydroxymethyl)-2-methoxycarbonyl-2,6a,6b,9,12a-pentamethyl-10-(3,4,5-trihydroxyoxan-2-yl)oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid2-AminopyridineCyclo(-L-Trp-L-Tyr)FlibanserinFusarochromanone3'-N'-AcetylfusarochromanoneDexrazoxane4-Hydroxybenzoic acidIsoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-AconineMaltotrioseDiltiazemValproic acidEthyl 4-methyl-5-[(propan-2-yl)oxy]-9H-pyrido[3,4-b]indole-3-carboxylate1-(5-Deoxypentofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dionePostinN5-acetyl-l-ornithineDihydrouracilRanitidineN-AcetylhistamineMethyldopaNicotinamideL-Valyl-L-phenylalanineTigecyclineTheophyllineTryptophanamideFerulic acid 4-O-glucuronideETHOPROPAZINEGlycyl-L-tyrosineCastamollissinLys-ThrArg-Gly-Asp(S)-Verimol_FSuccinic acid N,N-dimethylhydrazidePE(18:0/18:2)Octopamine, N-feruloyl-DorsomorphinOxytetracyclineFumonisin_A1PIP(16:2(9Z,12Z)/18:0)7-Methoxy-1,2,3,4-tetrahydroacridin-9-amine7-[2,6-dimethyl-8-(2-methylbutanoyloxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acidmyo-InositolAstragalinPyroglutamic acidGlucose 1-phosphateUridine 5'-diphosphate (UDP)Picropodophyllotoxin17.beta.-Estradiol 3-.beta.-D-glucuronidePerphenazineGlucosamine 6-phosphateBiochanin AN-MethylnicotinamideRilmenidineNisoldipine5-O-DesmethyldonepezilIsomaltosepomiferinCincassiol_B6-Aminonicotinamide4-Hydroxybenzyl cyanideRhazidigenine_Nb-oxideN-2-[4-(3,3-Dimethylallyloxy)phenyl]ethylcinnamideStreptomycin APentosidineDeoxyguanosinePurothionin_AIINylidrinQuinic acidAllixinTauro-beta-muricholic acidCamptothecinValerylcarnitineBambuterolLactate3,3',4,5'-Tetrahydroxy-trans-stilbene.beta.-Hydroxyphenylalanine6-KetoestriolThymidineLabetalol2-Hydroxyhexanoic acidVitexinPC(22:4(7Z,10Z,13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))Cucurbitacin_BIsocaproic acidVal-SerN2,N4-Bis(2-methoxyethyl)-2,4-pyridinedicarboxamidePaprazineMizolastine_(Mizollen)(7'R,8'R)-4,7'-Epoxy-3',5-dimethoxy-4',9,9'-lignanetriol_9'-glucosideN-TigloylglycineMalic acid3-Phosphoglyceric acidLSDDocebenoneArjunolic_acid_3-glucosideTanshinone IPiberalineArbutamineSecologanin[2-[docosa-7.10.13.16-tetraenoyloxy]-3-(octadecanoyloxy)propoxy]({[2.3.4.5.6-pentahydroxycyclohexyl]oxy})phosphinic acidPrenyl-L-cysteineHalopemideMandelic acidErucamideQuinupristinCanthaxanthin (Euglenanone)Sonchuionoside_CMaltoseLysoPC(22:2(13Z,16Z))Theanine3-Methyl-3H-imidazo[4,5-f]quinoxalin-2-amineO-DesmethylcarvedilolGln-MetHistamine3-Hydorxy-3-methylglutaric acid3-Furanmethanol_glucosideN-Nervonoyl-D-erythro-sphingosylphosphorylcholineN-AcetyltyrosineBetamethasone dipropionate(2-aminoethoxy)[2-[hexadec-9-enoyloxy]-3-[octadeca-1.11-dien-1-yloxy]propoxy]phosphinic acidFurcelleranOxypurinolYangonin6S,9R-Dihydroxy-4,7E-megastigmadien-3-one_9-[apiosyl-(1->6)-glucoside]Unshuoside_AN-Methyl-D-aspartic acid5'-DeoxyadenosineTorasemide12-Hydroxystearic acidDTyr-Val-Gly2-PiperidoneDiglycineRisedronic_acidDIMBOA + O-HexKoenigineMethionine sulfoxide1-(2H-1,3-Benzodioxol-5-yl)-2-[2,6-dimethoxy-4-(prop-2-en-1-yl)phenoxy]propyl_benzoateNormetanephrineS-Ethyl dipropylthiocarbamateSM(d18:1/22:0)Prolyl-ThreonineFlunarizineRaffinose4-Aminobutyric acid (GABA)Fluvoxamine_maleateLTD4Pyrrolidine(6beta,7alpha,12beta,13beta)-7-Hydroxy-11,16-dioxo-8,14-apianadien-22,6-olidePE(22:2(13Z,16Z)/P-16:0)MefloquineHT-2 ToxinLyciumoside_VIIIIsopentenyladenosineL-?Leucyl-?L-?alanineScorzonosideVindesinePE(P-18:1(9Z)/18:1(9Z))NicotinateN2-MaltulosylarginineTolterodinePyro-L-glutaminyl-L-glutamineVesnarinoneHydroxytyrosolPsoralenepiyangambinPhe-AlaLTC4LercanidipinefalseAstaxanthin Protects Against Ferroptosis and Oxidative Stress via Retinoic Acid-Mediated SLC7A11 Regulation by Lepagella murisOxidative stress and ferroptosis are central to the pathogenesis of many diseases, including those characterized by intestinal damage, where excessive lipid peroxidation and iron accumulation trigger cellular dysfunction. In this study, we investigate the protective effects of astaxanthin (ASTA), a potent antioxidant carotenoid, against dexamethasone (DEX)-induced oxidative stress and ferroptosis in the intestine. We demonstrate that ASTA supplementation significantly restores antioxidant defenses, enhancing key antioxidant enzymes. Furthermore, ASTA alleviates ferroptosis by upregulating GPX4 expression and reducing iron accumulation, thereby mitigating cellular damage. Using 16S rRNA sequencing and metagenomic analysis, we identify shifts in gut microbiota composition induced by ASTA, with a notable enrichment of Lepagella muris and other beneficial bacteria. These shifts correlate with the upregulation of retinol metabolism pathways, particularly those involving enzymes such as β-carotene monooxygenase 1 (BCMO1) and aldehyde dehydrogenase (ALDH). Metabolomic profiling further confirms that L. muris metabolizes ASTA to promote retinoic acid biosynthesis, which targets key ferroptosis-related genes, including SLC7A11, thereby inhibiting the activation of the ferroptosis pathway. RETINOIC ACID-mediated activation of SLC7A11 restores cellular redox balance, protecting against ferroptosis. Our findings provide mechanistic insights into how ASTA, through gut microbiota-mediated retinoic acid biosynthesis, modulates oxidative stress and ferroptosis pathways, offering a novel therapeutic approach for diseases associated with these processes. These results underscore the potential of microbiota-targeted interventions to enhance the efficacy of antioxidant therapies in treating oxidative stress-induced 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