MetaboLights

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ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/m_MTBLS13212_LC-MS_negative_hilic_metabolite_profiling_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/m_MTBLS13212_LC-MS_positive_hilic_metabolite_profiling_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/a_MTBLS13212_LC-MS_positive_hilic_metabolite_profiling.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/s_MTBLS13212.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/a_MTBLS13212_LC-MS_negative_hilic_metabolite_profiling.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/POS_Ib25CQ1C_ND3.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/POS_Ib25CQ1C_HFD2.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/POS_Ib25CQ1C_QC02.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/NEG_Ib25CQ1C_QC03.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/NEG_Ib25CQ1C_HFD2.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/NEG_Ib25CQ1C_ND3.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/NEG_Ib25CQ1C_ND6.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/POS_Ib25CQ1C_ND6.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/POS_Ib25CQ1C_QC03.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/NEG_Ib25CQ1C_QC02.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/POS_Ib25CQ1C_HFD6.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/NEG_Ib25CQ1C_HFD6.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/NEG_Ib25CQ1C_ND5.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/POS_Ib25CQ1C_ND1.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/POS_Ib25CQ1C_HFD4.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/NEG_Ib25CQ1C_ND1.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/NEG_Ib25CQ1C_QC01.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/NEG_Ib25CQ1C_HFD5.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/POS_Ib25CQ1C_HFD5.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/POS_Ib25CQ1C_ND5.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/POS_Ib25CQ1C_ND4.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/POS_Ib25CQ1C_QC01.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/NEG_Ib25CQ1C_ND4.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/POS_Ib25CQ1C_HFD3.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/NEG_Ib25CQ1C_HFD4.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212/FILES/RAW_FILES/NEG_Ib25CQ1C_HFD3.zipprimary200OKftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13212The UHPLC-MS raw data were converted into the common format by Progenesis QI software through baseline filtering, peak identification, peak integral, retention time correction, and peak alignment. Then, the data matrix containing sample names, m/z, retention time and peak intensities was exported for further analyses. At the same time, the metabolites were identified by searching database, and the main databases were the HMDB Metlin and the self-compiled Majorbio Database of Majorbio Biotechnology Co., Ltd. MetaboLightsPublicLiquid Chromatography MS - positive - HILICLiquid Chromatography MS - negative - HILIC100 μL liquid sample was added to a 1.5 mL centrifuge tube with 400 μL solution (acetonitrile: methanol = 1:1(v:v)) containing 0.02 mg/mL internal standard L-2-chlorophenylalanine to extract metabolites.The samples were mixed by vortex for 30 s and low-temperature sonicated for 30 min The effect and mechanism of gut flora metabolite deaminotyrosine on chronic inflammatory pain.Yanxia WeiXuzhou Medical Universitybrainmass spectrometry assay50 mg solid sample was added to a 2 mL centrifuge tube and a 6 mm diameter grinding bead was added. 400 μL of extraction solution methanol: water = 4:1 (v:v) containing 0.02 mg/mL of internal standardMus_musculushttps://www.ebi.ac.uk/metabolights/MTBLS13212XIA WEI. Xuzhou Medical University. No. 209, Tongshan Road, Yunlong District, Xuzhou City, Jiangsu Province. weiyx2007@aliyun.com.The UPLC system was coupled to a quadrupole-time-of-flight mass spectrometer Triple TOF TM5600+, Sciex, equipped with a electrospray ionization source operating in positive mode and negative mode. The optimal conditions were set as followed: source temperature at 550 oC ; curtain gas at 30 psi; both Ion Source Gas1 and Gas2 at 50 psi; ion-spray voltage floating ISVF at -4000V in negative mode and 5000V in positive mode, respectively; declustering potential at 80V; collision energyGroupweiyx2007@aliyun.comThe brain tissue of mice was washed with PBS and frozen in liquid nitrogen for 30min, then transferred to -80 for storageMetabolomicsWaters ACQUITY UPLC H-Class Systemuntargeted analysisMus_musculusuntargeted metabolitesbrainAB SCIEX TripleTOF 6600TreatWaters ACQUITY UPLC H-Class Systemuntargeted analysisMus_musculusuntargeted metabolitesbrainAB SCIEX TripleTOF 6600TreatThe LC-MS/MS analysis of sample was conducted on a SCIEX UPLC-Triple TOF 6600 system equipped with an ACQUITY HSS T3 column (100 mm × 2.1 mm i.d., 1.8 μm; Waters, USA) at Majorbio Bio-Pharm Technology Co. Ltd. (Shanghai, China).The mobile phases consisted of 0.1% formic acid in water:acetonitrile (95:5, v/v) Pe(o-18:1/2:0)CorticosteroneLeu-ProMicrocystin-LRRiboflavinStreptidineButyryl trihexyl citrateSitosterol 3-O-(6'-O-stearyl-beta-D-glucoside)Stearoyl ethanolamideStearoylcarnitine7a,12a-Dihydroxy-3-oxo-4-cholenoic acid5beta-Cholestane-3alpha,7alpha,24,26-tetrolCimiracemoside d3-(3-{[3-(Diethylamino)-3-oxetanyl]methyl}-1,2-oxazol-5-yl)phenol1-(3,4-dimethoxyphenyl)ethan-1-one oximeChrysophanol-8-o-beta-d-glucopyranoside(2-Acetyloxy-3-hydroxypropyl) (E)-octadec-9-enoateL-HistidineCholest-4-en-3-oneRphdhdPe(o-18:1/22:6)Momordicin IIGln-Ile-LysMethylphosphateAnisperimusThr-Pro-LysL-ProlineUreaPe(22:2/18:4)1-(3-nitrophenyl)-2-[(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanoneN-Acetylaspartic acidUrsolic acidGPCho(17:0/15:1)N-benzylformamideGPEtn(14:0/22:2)GPCho(18:3/22:4)Cinnamic acidLpe(20:4)L-Pipecolic acidEpilupeol4-ethynylanilinePc(o-20:5)Trp-Ala-ArgOleic acidPe(p-16:0/0:0)Chenodeoxycholylaspartic acidPhosphoenol pyruvateHis-Tyr-Val3-(3-hydroxydecanoyloxy)octanoic acidPropyl alcoholLpe(20:5)N-HeptanoylglycineFexofenadine(Z)-9-Cycloheptadecen-1-one1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine4-Ethyl-7,11-dimethyldodeca-trans-2-trans-6-1-o-trien-1-alSolutol HS 15PC(DiMe(11,3)/18:1(12Z)-2OH(9,10))Gln-Pro-LysGPEtn(16:1/22:4)8-Hydroxylinoleic acidOctadeca-9,12-dienalgamma-Glu-GluOleamideBis(2-ethylhexyl)amineApo-14'-zeaxanthinal1,2,3-Trihydroxyhenicos-12-en-4-one7,13-Eperudien-15-oic acidPantothenic acid12-methyltridecanoic acidBis(p-methylbenzylidene)sorbitolPe(20:5/24:5)GuanosineAsp-Asp-Thr4-[(2-nitrophenyl)sulfonylamino]butanoic acidProstaglandin d2Cytochalasin BCylindrol BGPCho(18:2/18:2)(R)-1-O-[b-D-Glucopyranosyl-(1->6)-b-D-glucopyranoside]-1,3-octanediolS-(2-Carboxyethyl)-L-cysteine2-hydroxycinnamic acid3,4-Methylenepimelic acidTetradecanolGlyceric acidHydroxylated lecithinHexadecanedioic acidLpe(20:3)AnamorelinPe(o-16:1/18:1)Fenvalerate4-tert-Butylcyclohexyl acetate3-Butyn-1-alFructose-1,6-diphosphateGlu-PheCurdioneN-Nervonoyl CysteineIsovaleronitrileLovastatinLpc(20:2-sn1)4-(Hydroxymethyl)-3-(1-hydroxy-5-methylhexyl)oxolan-2-oneMuzanzageninBeclomethasoneAgavoside AIle-GluGlu-MetPS(6 keto-PGF1alpha/18:1(11Z))IsoindolineGPCho(20:5/20:4)DiethanolamineLiquiritinLpc(20:3-sn1)Adenosine{4-[({2-[3-Fluoro-4-(Trifluoromethyl)phenyl]-4-Methyl-1,3-Thiazol-5-Yl}methyl)sulfanyl]-2-Methylphenoxy}acetic AcidPeg n14IsorheagenineSinefunginCarindoneL-TyrosineSpb(14:0_2o)Tyromycic acidGlu-TrpArgininosuccinic acidMyotoxin APhyscion 8-gentiobiosideStearoyl lysophosphatidylethanolaminePeimineNervonyl carnitineDeoxyguanylic AcidAsn-Tyr-SerL-PhenylalaninePc(36:4)RiboprineCholest-5-en-3-ol4-aminovaleric acid betaineMyristoyllysophosphatidylcholineAtecegatran metoxilTriethylene glycolN-ChlorophenylalanineN-formylmethamphetamineLdgcc(36:10)SpermidinePro-Pro-ProSphingosineTricosanoylglycineIsofraxidin13-HydroxyoctadecanoylcarnitineTaurocholic acidN-Docosahexaenoyl Asparagine2-(3-methyl-1-benzothiophene-2-carbonyl)benzoic acid5-MethylthiopentylglucosinolateMethenamineBis[2-(2-butoxyethoxy)ethyl]hexandioate(+)-DehydrovomifoliolMycobactinsDG(PGD2/i-20:0/0:0)3-Methoxy-4,5-methylenedioxy-N-methylamphetaminePeg n72-hydroxy-6-[(8Z,11Z)-pentadeca-8,11-dienyl]benzoic acid5-Hydroxy-4-oxo-L-norvalineProteinase inhibitor e 64CabergolinePc(txb2/p-18:1(11z))AsperageninCer(9:0_3O/16:1_(2OH))Cer(18:2_2O/18:0)PG(PGD1/a-13:0)BenzyldimethyltetradecylammoniumGuaninePc(pgj2/p-18:0)Pe(16:0/22:6)2-Phenylethyl octanoateStreptolydiginN-(2-chloro-5-methylphenyl)-2-(2-methyl-1,3-thiazol-4-yl)acetamidePe(14:0/22:2)1-(Carboxyethylthio)tetradecane2-hydroxy-4-methoxy-3,5-bis(3-methylbut-2-enyl)-6-pentylbenzoic acid13-Tetradecene-1,3-diyne-6,7-diolN,N-Dimethylacetamide15-oxoede1,2-CyclohexanediolMgdg(2:0/18:1)Bis(2-ethylhexyl)adipateBiotin thiamineValnemulinMethyl hexadecanoic acidCysteine-glutathione disulfide4-[(4-Aminophenyl)(4-iminocyclohexa-2,5-dien-1-ylidene)methyl]-2-methylaniline3,4-DiaminopyridinePe(22:6/0:0)Mycarose8(R)-Hydroperoxylinoleic acidLatrunculin BLpc(20:1-sn1)Lys-Leu-Gln3,5-di-tert-butyl-4-hydroxybenzyl alcoholTerpestacinL-GlutathioneCholine glycerophosphateAla-Lys-Leu-AspLpc(19:1-sn1)Linoleoyl ethanolamideAs 1-1Lepidiumterpenyl ester2-(4-methoxybenzoyl)-N-methyl-2-azaspiro[4.4]nonane-4-carboxamideCinobufagin3,4,5-Tribenzoyloxypentyl benzoateLeu-Leu1-(2,2-Dichloroethyl)-1-nitrosoureaGlucose 6-phosphateL-AlaninePG(PGE2/i-20:0)Indole-3-carboxaldehydeO-Acetylcarnitinium15-Deoxyprostaglandin J2Flavin adenine dinucleotideGPCho(16:0/18:3)PyroglutamylisoleucineFloionolic acidN-(6-Cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl)-N-methylethanesulfonamidePc(txb2/p-18:0)Carnitine1-[3-(azepan-1-yl)-2-[(4-methylphenyl)methoxy]propyl]azepaneMelleolide BAdenosine PhosphateMelleolide E2-[1-[(2,3-dimethoxyphenyl)methyl]piperidin-4-yl]-3-phenyl-2-azaspiro[3.5]nonaneTryptopholL-LysineN-acetylneuraminic acidPc(o-14:0)GPEtn(22:6/20:4)Mg(18:1(9z)/0:0/0:0)Pc(pgd1/p-16:0)N-Docosahexaenoyl Arginine8-AcetoxyelemolAMPK Inhibitor, Compound COctylamineAmylamineCamellimidazole fSphinganineCer(8:1_2O/5:0)Pe(o-18:2/22:6)8-Hydroxy-4(6)-lactarene-5,14-diolRose oxide (cis)Dulciol C9,10-Epoxy-18-hydroxy-octadecanoic acidPe(20:1/18:3)Ornithylamphotericin methyl ester1,3-dicyclohexylureaDipalmitoylphosphatidylglycerolL-3-Aminodihydro-2(3H)-furanonePC(6 keto-PGF1alpha/22:2(13Z,16Z))Asi-222VerdamicinDihydrolipoamide5-(3-Pyridyl)-2-hydroxytetrahydrofuran2,2,4-Trimethyl-1,3-pentanediol diisobutyrateTexanolEpothilone BPc(38:6)GPEtn(18:3/22:4)3-Oxo-12,18-ursadien-28-oic acidCys-AsnLpc(20:4-sn1)D-fructose, 1,6-bis(dihydrogen phosphate)5'-deoxy-5'-methylthioadenosinePe(o-20:3/18:3)1-Acetoxy-2-hydroxy-16-heptadecen-4-oneAndrostane-3,17-diol dipropionateAdenosine 3'-monophosphateBoldenone undecylenate3-guanidinopropionic acid[12]-GingerdiolPc(o-15:0)NetilmicinL-Leucinebeta-Tyrosine2-Azaspiro[4.5]decan-3-oneAncistrocladinePe(o-14:0/4:0)Vitamin D2 3-glucuronidePs(22:6/22:6)Fructose lactateStyreneGPEtn(20:4/18:2)3-Methyl-1-butylamineRetinoic acidDioctyl maleateNonaethylene glycolSm(34:1_2o)Pe(19:2/19:2)N(4)-Octadecyl-1-arabinofuranosylcytosineButylisopropylamine1,3-benzodioxolylbutanamineTrans-3-indoleacrylic acidGeranylgeraniolFraxidinCarnosineSoyasapogenol ELauryldiethanolamineLpc(17:0)TangeraxanthinLpe(16:1)3-Methoxytyramine6''-O-CaffeoylastragalinLinoleamidePhosphateL-TryptophanTriethanolaminePro-ArgLpc(22:6-sn1)Nonactinic acidSerotoninN-cyclooctyl-1-(2-naphthalen-1-ylacetyl)piperidine-3-carboxamide3-Hydroxyheptadecanoylcarnitine4a-Methylzymosterol-4-carboxylic acidMeteneprost3-Benzyl-5-(6-carboxyhexyl)-1-(2-cyclohexyl-2-hydroxyethylamino)hydantoinRhodojaponin iii8-OxoguanosineBis(2-ethylhexyl) sebacateLpe(16:0)N-acetylaspartylglutamic acidDibutyl sebacatePc(o-16:0)HexylaminePyrrolizidineL-ValineSm(12:1_2o/24:0)PlumierideUracilGlu-GluVidarabine2-n-Propylthiazolidine-4-carboxylic acidD-4'-PhosphopantothenateN-Nervonoyl Methionine1,3-Dihydroxypropan-2-yl oleateCortivazolN-methyl arachidonoyl amineCreatineSphingosine 1-phosphateL-Glutamic AcidPhytosphingosinePentadecylamineOxiglutationeSM(d18:1/18:0)4-Amino-2,2,6,6-tetramethylpiperidin-1-olFucoxanthinolMethyl 3-epi-4,5-didehydrojasmonateLeu-Pro-GlnArg-Ser-SerSer-Lys-ArgPantetheine 4'-phosphateGly-Arg-Gly-Asp-Ser-Pro2-phenylpropionic acidLauramine oxide(9S,10S)-9,10-dihydroxyoctadecanoatePe(o-16:1/22:6)1-palmitoyl-sn-glycero-3-phosphocholineDiisobutyl adipateCeanothine CSpermineBrassinolideHypoxanthine1-octadecanamineN-(7-methoxy-4,5-dihydrobenzo[e][1,3]benzothiazol-2-yl)furan-2-carboxamide1-palmitoyl-2-myristoyl-sn-glycero-3-phosphocholinePalmitoyl ethanolamide8,8-Diethoxy-2,6-dimethyl-2-octanolPe(o-18:2/20:4)3h-TaurinePhosphatidylcholine lyso 18:03-Hydroxysintaxanthin9-F1-phytoprostaneKaempferol 3-O-beta-D-glucopyranosyl-(1->2)-beta-D-6-acetyl-glucopyranoside4,6-dihydroxy-3-(1-hydroxyethyl)-5-methoxy-3H-2-benzofuran-1-oneCholine PhosphateSpongouridinPe(22:6/22:6)Benzoyl-DL-arginine-naphthylamide41-O-demethylrapamycinArctiol3alpha-hydroxy-3-deoxyangolensic acid methyl esterAdenine2-(4-oxoquinazolin-3(4h)-yl)ethyl isobutyrateNorvaline betainePG(PGD1/i-20:0)L-SerineInosine(+/-)-MyristoylcarnitineLumichromeGentamicin C2N-Stearoyl CysteineP-toluquinone16,17-Dihydro-16alpha,17-dihydroxygibberellin A4 17-glucoside3,6,9,12,15,18,21,24,27,30-decaoxadotriacontane-1,32-diolSpb(16:1_2o)GPCho(18:4/18:0)Lpe(18:1)GPCho(20:4/16:0)CaffeineMaleylacetoacetic acidGPCho(22:6/20:3)Cer(13:1_2O/36:10)GPEtn(22:2/18:4)Decaethylene glycolProstaglandin a1Sebacic acidL-MethionineGenipin 1-gentiobiosideO-PhosphorylethanolamineNicotinamide adenine dinucleotideLpe(o-18:2)NicotinamideN,n-DimethylguanosineWithanolide BN-Myristoyl Arginine2-hydroxy-7-methyl-2-propan-2-ylfuro[3,2-h]isoquinolin-3-oneDiethyl phthalateTetradecan-2-olLeu-Pro-ArgMg(22:6)GPCho(18:1/16:1)2,2,6,6-Tetramethyl-4-piperidinoneDodemorphPenitrem DOleoyl ethanolamideGinsenoyne JProtopanaxatriol1-AGPe(pge1/p-18:0)Docosahexaenoic acid-d5L-Pyroglutamic acidDiosmetin-7-o-rutinosideHexamethoxymethyl melamine4-Chloro-2-nitrobenzylalcoholPyropheophorbide aO-AcetylcarnitineTyr-Arg-AspCyclopentanol(S)-2-Methyl-1-butanol O-beta-D-GlucopyranosidePe(o-10:0/6:0)D-Sedoheptulose 7-phosphateL-GlutamineN,n-diisopropylethylamineLpc(18:2-sn1)Lpe(18:2)Lpc(16:1-sn1)Leu-Glu15-methylprostaglandin e1GymnodimineLdgts(18:1)Indoline4-Deoxytetronic acid4-Amino-3-hydroxybutyratePMeOH(18:0/22:6)GPCho(14:0/20:3)Dilauryl thiodipropionateAngiotensin (1-7)PA(6 keto-PGF1alpha/14:1(9Z))BenzaldehydeL-Aspartic AcidCreatinine aspartateErucamideN6-(1,2-Dicarboxyethyl)-AMPN-Arachidonoyl Threonine(+/-)5(6)-EET EthanolamideO-(17-Carboxyheptadecanoyl)carnitine8,10-Dihydroxy-3-longipinen-5-one, diangeloyl5-hete lactoneDmap-ethyl-pafKhellactoneGPCho(14:0/20:2)OxypurinolBeta-ThujaplicinIsonicotinamideHeptadecasphinganine5-DeoxymyricanoneEpigallocatechinGPCho(20:1/18:4)Methionine sulfoxidePersenone BGly-His-LeuRoburic acidLacto-N-tetraose(5E,8E,11E)-13-[(2S,3S)-3-Pentylthiiran-2-yl]trideca-5,8,11-trienoic acidTuckolide_ Decarestrictine DHexadecanamideLpc(18:1)4-Hydroxyphenylpyruvic acid2-undecyl-thiazolidine-4-carboxylic acidPe(p-18:0/0:0)N-(3-cyano-4,5-dimethyl-2-thienyl)-2-(4-phenylpiperazino)acetamidePiperidineD-Ornithine(6beta,7alpha,12beta,13beta)-7-Hydroxy-11,16-dioxo-8,14-apianadien-22,6-olideD-Glucuronic acid 1-phosphate10-Oxo-11-octadecen-13-olidePe(o-18:2/18:1)1-o-palmitoyl-2-o-acetyl-sn-glycero-3-phosphorylcholineGlycolaldehyde2,2,5,5-tetramethylpyrrolidine-3-carboxamideLpc(18:0)HemateinNorvalineLubiprostone3,7-dihydropurin-6-onefalseThe effect and mechanism of gut flora metabolite deaminotyrosine on chronic inflammatory painThis study focuses on deaminotyrosine DAT, a metabolite of gut flora, and systematically investigates its effect on chronic inflammatory pain as well as the underlying mechanism. The research takes high-fat diet HFD as a key entry point for the background, as HFD often leads to an imbalance in the structure of gut flora. This imbalance may affect the production of intestinal metabolites including DAT, and thereby be associated with the occurrence and development of chronic inflammatory pain.2026-08-102025-10-24MTBLS13212