The UHPLC-MS raw data were converted into the common format by Progenesis QI
software through baseline filtering, peak identification, peak integral,
retention time correction, and peak alignment. Then, the data matrix containing sample names,
m/z, retention time and peak intensities was exported for further analyses. At the same time, the
metabolites were identified by searching database, and the main databases were the HMDB
Metlin and the self-compiled Majorbio
Database of Majorbio Biotechnology Co., Ltd.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - positive - HILIC","Liquid Chromatography MS - negative - HILIC"],"chromatography_protocol":["100 μL liquid sample was added to a 1.5 mL centrifuge tube with 400 μL solution (acetonitrile: methanol = 1:1(v:v)) containing 0.02 mg/mL internal standard L-2-chlorophenylalanine to extract metabolites.The samples were mixed by vortex for 30 s and low-temperature sonicated for 30 min
"],"publication":["The effect and mechanism of gut flora metabolite deaminotyrosine on chronic inflammatory pain."],"submitter_name":["Yanxia Wei"],"submitter_affiliation":["Xuzhou Medical University"],"organism_part":["blood serum"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["50 mg solid sample was added to a 2 mL centrifuge tube and a 6 mm diameter grinding bead was added. 400 μL of extraction solution methanol: water = 4:1 (v:v) containing 0.02 mg/mL of internal standard
"],"organism":["Mus_musculus"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS13221"],"author":["XIA WEI. Xuzhou Medical University. No. 209, Tongshan Road, Yunlong District, Xuzhou City, Jiangsu Province. weiyx2007@aliyun.com."],"data_transformation_protocol":["The UPLC system was coupled to a quadrupole-time-of-flight mass spectrometer Triple
TOF TM5600+, Sciex, equipped with a electrospray ionization source operating in
positive mode and negative mode. The optimal conditions were set as followed: source
temperature at 550 oC ; curtain gas at 30 psi; both Ion Source Gas1 and Gas2 at 50 psi;
ion-spray voltage floating ISVF at -4000V in negative mode and 5000V in positive mode,
respectively; declustering potential at 80V; collision energy
"],"study_factor":["Group"],"submitter_email":["weiyx2007@aliyun.com"],"sample_collection_protocol":["Sample Preparation: Mice should be fasted for 12 hours before the experiment, with free access to water, to reduce the interference of food on serum metabolites.Blood Collection Operation: Blood is collected using a capillary tube, with a collection volume of 0.1 mL Serum Separation: Place the collected blood in a centrifuge tube without anticoagulant, let it stand at room temperature for 30 minutes to allow coagulation, then centrifuge at 3500 rpm for 15 minutes, and aspirate the upper pale yellow serum.Sample Storage: Aliquot the separated serum into cryovials, quickly store them in a -80°C refrigerator, and avoid repeated freeze-thaw cycles.
"],"omics_type":["Metabolomics"],"study_design":["Waters ACQUITY UPLC H-Class System","untargeted analysis","Thermo Scientific Q Exactive HF-X","Mus_musculus","blood serum","untargeted metabolites","serum","Treat"],"curator_keywords":["Waters ACQUITY UPLC H-Class System","untargeted analysis","Thermo Scientific Q Exactive HF-X","Mus_musculus","blood serum","untargeted metabolites","serum","Treat"],"mass_spectrometry_protocol":["The LC-MS/MS analysis of sample was conducted on a SCIEX UPLC-Triple TOF 6600
system equipped with an ACQUITY HSS T3 column (100 mm × 2.1 mm i.d., 1.8 μm; Waters,
USA) at Majorbio Bio-Pharm Technology Co. Ltd. (Shanghai, China).The mobile phases
consisted of 0.1% formic acid in water:acetonitrile (95:5, v/v)
"],"metabolite_name":["4-[3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxybenzaldehyde","Lysopi(18:0/0:0)","Colforsin Daropate","Salmeterol","Phenylacetylglutamine","D-Alpha-Hydroxyglutaric Acid","Gpetn(18:0/22:6)","Arabidiol","Tyrosol 4-Sulfate","5,6-Dehydro Arachidonic Acid","Aspartame","2-Oxoadipic Acid","Isophthalic Acid","Pe(42:7)","Lumirubin","Sebiferic Acid","1-Nonadecanoyl-Glycero-3-Phosphoserine","Tetranor-Pgfm","Deoxycholic Acid","2-Hydroxy-P-Mentha-1,8-Dien-6-One","(3B,6B,8A,12A)-8,12-Epoxy-7(11)-Eremophilene-6,8,12-Trimethoxy-3-Ol","Indoxyl Sulfate","P-Cresol Glucuronide","Dg(15:0/18:4(6Z,9Z,12Z,15Z)/0:0)","3H-Indole-3-Propanoic Acid,A-Amino-","Cer(D17:1/Txb2)","Gabazine","Ethyl Myristate","Prostaglandin H2","12'-Apo-B-Carotene-3,12'-Diol","Citrulline","2',3-Dihydroxy-4,4',6'-Trimethoxychalcone","1-(Methylthio)Ethyl 2-Propenyl Disulfide","Pi(38:4)","Medica 16","Pe(P-16:0/22:4)","4-Aminonicotinic Acid","N-Formyl-L-Methionine","(6Alpha)-Hydroxycampestanol","Lupinine","1-Oleoylglycerophosphoserine","Androsterone Glucuronide","Ingenol","Methyl 4-Chloro-1H-Indole-3-Acetate","Ps(18:1(11Z)/20:0)","Hyocholic Acid","Homovanillic Acid Sulfate","Prostaglandin E2","Kinetensin 4-7","Griseofulvin","Kainic Acid","Hydrocortisone Hemisuccinate","Murocholic Acid","Lysope(0:0/20:0)","Beta-Tocotrienol","4-Ethylphenol","Milbemycin Alpha10","2,3-Dinor Prostaglandin E1","Cumi-101","Taurohyocholate","Dg(14:1(9Z)/14:0/0:0)","Ilexgenina","Pregnanediol","Geraniol","1-Nitro-5-Glutathionyl-6-Hydroxy-5,6-Dihydronaphthalene","Histidylcysteine","2-Ketoglutaric Acid","Gamma-Glutamyltyrosine","Lysope(P-16:0/0:0)","Ciramadol","Dg(15:0/14:1(9Z)/0:0)","Delmadinone Acetate","Dg(18:3(10,12,15)-Oh(9)/I-15:0/0:0)","Pseudouridine","Lysopc(20:2(11Z,14Z)/0:0)","12-Hete","Thromboxane","27-Deoxy-5B-Cyprinol","2-Amino-3-Methylsuccinic Acid","4-Hydroxy-16,18-Tritriacontanedione","Octocrylene","Dg(18:2(9Z,12Z)/15:0/0:0)","Isocitric Acid","D-Lyxose","3-Amino-2-Naphthoic Acid","Dodecanedioic Acid","4-Tert-Octylphenol","8-Hydroxyacyclovir","8-Amino-7-Oxononanoic Acid","(6R,8Z)-6-Hydroxy-3-Oxotetradecenoic Acid","Thr Phe Lys Glu","Hexadecanedioic Acid","Bioadykinin Fragment 1-5","Alpha-Bisabolol Oxide A","Chenodeoxycholic Acid","3Alpha,7Alpha,12Alpha-Trihydroxy-5Beta-Cholestanate","5,8,11-Trihydroxyoctadec-9-Enoic Acid","Pentalenic Acid","Morph","Trans-2-Dodecenoylcarnitine","Pc(18:0E/20-Hete)","Polyporusterone C","Pe(34:1)","Tetrahydro-6-(2-Hydroxy-16,19-Dimethylhexacosyl)-4-Methyl-2H-Pyran-2-One","3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate","Lysopc(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)","5-Methoxytryptamine","Methylisopelletierine","Gpetn(20:4/22:6)","3-Hydroxybenzoic Acid","Elemicin","Camonagrel","2-Hydroxypentanoic Acid","Rhamnose","Dehydronootkatone","Polyporusterone G","Sagequinone Methide A","Dg(14:0/18:2(9Z,12Z)/0:0)","2,3-Dimethoxy-5-Methyl-6-(9'-Carboxynonyl)-1,4-Benzoquinone","Ps(18:1(9Z)/18:0)","27-Hydroxyisomangiferolic Acid","(2-Oxo-2,3-Dihydro-1H-Indol-3-Yl)Acetic Acid","Paramethadione","Lovastatin","Prostaglandin A1","Isopentenyladenine","D8'-Merulinic Acid A","25-Ethoxy-24-Methoxycylcoartanol","Plumbagin","Lacosamide-Glucuronide","Gpetn(16:0/18:1)","Gamma-Linolenic Acid","Mandelic Acid Sulfate","Loliolide","N-Lauroylglycine","Antibiotic Sb 202742","1-[5-(Trifluoromethyl)-2-Pyridyl]Piperidine-4-Carboxylic Acid","Fa(18:1+2O)","Prostaglandin B1","Pi(22:4(7Z,10Z,13Z,16Z)/6 Keto-Pgf1Alpha)","Gpetn(16:1/22:6)","Fenoprofen Glucuronide","Pe(17:0/0:0)","Lysope(P-18:1(9Z)/0:0)","Uric Acid","Linoleic Acid","Dhmboa Hexose","Delta-Tocotrienol","Lysopc(20:5(5Z,8Z,11Z,14Z,17Z)/0:0)","7A,12A-Dihydroxy-Cholestene-3-One","14,15-Dihetre","19-Hydroxy-Pga2","Corchoionol C 9-Glucoside","N-Acetylanthranilic Acid","Monobutyl Phthalate","Lysopa(0:0/16:0)","Lysopc(20:4(5Z,8Z,11Z,14Z)/0:0)","(S,E)-Zearalenone","Schleicherastatin 3","Melilotoside","8,11-Eicosadiynoic Acid","18-Hydroxyoleate","2-Hydroxy-3-Methylpentanoic Acid","Pc(17:2(9Z,12Z)/0:0)","Glabric Acid","Pe(18:2/0:0)","Isokobusone","5(S),14(R)-Lipoxin B4","Norethindrone Acetate","N-Acetyl-L-Aspartic Acid","Pe(22:5(7Z,10Z,13Z,16Z,19Z)/P-18:0)","Prohydrojasmon","Ajoene","2-Dodecanone","3-Amino-3-(4-Hydroxyphenyl)Propanoic Acid","Gibberellin A5","15-Deoxy-Delta-12,14-Prostaglandin J2","Gpetn(18:2/18:1)","Deoxynivalenol","Parylene C","4-Decan-4-Ylbenzenesulfonic Acid","9-D-Hydroperoxylinoleic Acid","Butofilolol","2-Methylindoline","4-Hydroxydebrisoquine","2-Dodecylbenzenesulfonic Acid","Geosmin","N-(4-Methoxybenzyl)-N'-(5-Nitro-1,3-Thiazol-2-Yl)Urea","3-Tert-Butyladipic Acid","Oxotremorine","Benzyl Glycinate","Pe(34:2)","Dg(15:0/22:5(7Z,10Z,13Z,16Z,19Z)/0:0)","Isodeoxycholic Acid","Gpetn(18:2/18:0)","Docosadienoate (22:2N6)","Enterolactone 3''-Sulfate","7,8-Dehydro-Beta-Micropteroxanthin","Pe(20:1/0:0)","4-Methylene-2-Octyl-5-Oxotetrahydrofuran-3-Carboxylic Acid","Triptohypol F","Ganolucidic Acid E","9-Tetradecenoic Acid","Arg-Thr-Lys-Arg","Tetracosahexaenic Acid","3A,7A-Dihydroxy-5B-Cholestan-26-Al","Vicriviroc","Sm(D42:2)","2-Polyprenyl-6-Methoxy-1,4-Benzoquinone","Erucic Acid","Hydroxysebacic Acid","Docosahexaenoic Acid","Fahfa(16:1(9Z)/9-O-16:0)","Tetradecanedioic Acid","Cefpodoxime","Sm(D34:2)","Acetamido Thiadiazole Butyl Sulfonamide","Biotin Sulfoxide","11-Oxahexadecanolide","Acetyl-N-Formyl-5-Methoxykynurenamine","Xanthosine","3-Hydroxypentadecanoic Acid","(+/-)12,13-Dihome","2-(3-(8-Hydroxyoctyl)Phenoxy)Acetic Acid","Dodecyl Benzenesulfonate","Ps(15:0/22:2(13Z,16Z))","3,4-Dimethyl-5-Pentyl-2-Furanpropanoic Acid","Glycylleucine","Pg(Pgf2Alpha/I-19:0)","Pe(22:6/0:0)","4-Hydroxy-3-Methoxyphenylglycol Sulfate","Norgestrel","Cer[Ns](D34:1)","P-Mppf","Polyethylene, Oxidized","Stearidonic Acid","Suberic Acid","Petroselinic Acid","Gpetn(18:1/20:4)","12,13-Epoxy-9-Octadecenoic Acid","Mg(0:0/22:2(13Z,16Z)/0:0)","Terpestacin","Sobetirome","Ethacrynic Acid","Koenimbine","Myristyl Sulfate","Mevalonic Acid","Sm(D34:1)","2,6-Dihydroxybenzoic Acid","N(4)-Oleylcytosine Arabinoside","Glutamylvaline","4-Acetamidobenzoic Acid","Pe(36:2)","(S)-2-Acetamido-3-(4-Chlorophenyl)Propanoic Acid","Leptin F","Heliangin","Lactarorufin A","2-Aminoindan-2-Carboxylic Acid","Eicosapentaenoic Acid","Fahfa(18:1(9Z)/13-O-18:0)","Lysopc(20:3(5Z,8Z,11Z)/0:0)","6-Thioinosine-5'-Monophosphate","Lysope(0:0/22:0)","2-(Acetylamino)Hexanoic Acid","13,16,19-Docosatrienoic Acid","Pe(18:1E/20-Hdohe)","Ibuprofen","2'-Deoxyuridine","Muricin E","Leucylhydroxyproline","7A-Hydroxy-Cholestene-3-One","(3Beta,5Alpha,6Beta,24R)-Stigmastane-3,5,6-Triol","2-Methylglutaric Acid","5-Methoxysalicylic Acid Sulfate","Lysope(20:0/0:0)","10-Hydroxydecanoic Acid","Triton X 100","Pe(36:3)","Tricarballylic Acid","6-Hydroxy-1H-Indole-3-Acetamide","Dg(18:3(9,11,15)-Oh(13)/0:0/I-17:0)","17-Aminogeldanamycin","Gpetn(20:4/20:4)","Hydroquinone","Pyrogallol-2-O-Glucuronide","N-Acetylsulphadiazine","Dg(14:1(9Z)/16:1(9Z)/0:0)","Fa(18:2+3O)","Cohumulone","Itaconic Acid","2,2'-(3-Methylcyclohexane-1,1-Diyl)Diacetic Acid","Tulipinolide","Gpetn(18:2/20:0)","Genistein","Fa(18:3+2O)","Sm(D19:0/Lte4)","Lamivudine Sulfoxide","1,5,6,7-Tetrahydro-4H-Indol-4-One","5-(4-Methyl-5-Oxo-2H-Furan-3-Yl)Pentanoic Acid","Phenylpyruvic Acid","Ceanothenic Acid","Gamma-Glutamylglutamine","Medicagenic Acid","Triptophenolide","12-Hhtre","17Z-Hexacosenoic Acid","4-(Undecan-5-Yl)Benzene-1-Sulfonic Acid","Gpetn(20:2/20:4)","Octanoic Acid","3-Methyl-2-Oxovaleric Acid","Pe(36:1)","Dg(18:1(11Z)/15:0/0:0)","3Alpha,7Alpha-Dihydroxycoprostanic Acid","Traumatic Acid","5-Phenyl-1,3-Oxazinane-2,4-Dione","L-Prolyl-4-Hydroxy-L-Prolin","Pe-Nme(18:3(9Z,12Z,15Z)/22:0)","Alisol A","Aleuretic Acid","Pe(P-16:0/22:6)","Sm(D19:1/Lte4)","Lysope(P-18:0/0:0)","Oxidized Glutathione","Prenyl Glucoside","Ent-17-Oxo-15-Kauren-19-Oic Acid","Ergosterol Acetate","6B-Angeloyl-3B,8B,9B-Trihydroxy-7(11)-Eremophilen-12,8-Olide","Cynaratriol","Ethisterone","Dg(8:0/I-19:0/0:0)","Taurine","Pc(38:6)","Docosapentaenoic Acid","Allantoin","Janthitrem C","Pe(16:1/0:0)","Flumethasone","4',5,7-Trihydroxy-3,6-Dimethoxyflavone","Murrayenol","Acexamic Acid","Daidzein 4'-Sulfate","5-[3-Hydroxy-2-(Hydroxymethyl)Phenyl]Pent-4-Ene-2,3-Diol","Citramalic Acid","Dodecyl Sulfate","2-Hydroxyethanesulfonate","Gpetn(18:2/16:0)","Ricinoleic Acid","Pe(P-16:0/20:4(8Z,11Z,14Z,17Z))","13,14-Dihydro-15-Keto-Tetranor Prostaglandin D2","Dihydroalbocycline","Pe(20:0/22:6(4Z,7Z,11E,13Z,15E,19Z)-2Oh(10S,17))","Dg(18:1(12Z)-2Oh(9,10)/0:0/A-15:0)","5Alpha-Cyprinol","Cohibin C","N-Stearoyl Tryptophan","3-[4-Hydroxy-3-(3-Methyl-2-Butenyl)Phenyl]-2-Propenal","1-O-Isopentyl-3-O-Octadec-2-Enoyl Glycerol","Dihyroxy-1H-Indole Glucuronide I","Cholesterol Sulfate","Dump","(9S,10S)-9,10-Dihydroxyoctadecanoate","Gemfibrozil","Glycerophospho-N-Palmitoyl Ethanolamine","2,5-Di-Tert-Butylhydroquinone","Eicosopentanoic Acid","4-Methylbenzoic Acid","1-Heneicosanoyl-Glycero-3-Phosphoserine","Pe(P-18:0/22:4(7Z,10Z,13Z,16Z))","Phenaceturic Acid","Pe-Nme2(18:2(9Z,12Z)/20:3(8Z,11Z,14Z))","Cinncassiol A","Soyasapogenol D","Ethyl Glucuronide","2-Octylpent-2-Enedioic Acid","Tridecanedioic Acid","Dg(20:4(5Z,8Z,11Z,14Z)-Oh(16R)/0:0/17:0)","Pe(18:3/0:0)","Gpetn(18:0/18:1)","1B-Furanoeudesm-4(15)-En-1-Ol Acetate","Nonactinic Acid","5-Carboxy-2'-Deoxyuridine","Pc(18:1E/9-Hode)","Ruscogenin","3-Methylcrotonylglycine","4-[(2-Cyclohex-1-Enylethyl)Amino]-4-Oxobut-2-Enoic Acid","Dg(18:3(9Z,12Z,15Z)/15:0/0:0)","Dihydrolipoate","Deoxycholylphenylalanine","Cinncassiol C3","3-Indolehydracrylic Acid","Cinncassiol C2","Gpetn(18:0/18:2)","Pe-Nme2(18:0/18:2(9Z,12Z))","Chlorphenacil","Leukotriene B4","6-Ethylchenodeoxycholic Acid","Molinate","8-Hdohe","Mevastatin","8'-Hydroxyabscisate","2,4,5,7Alpha-Tetrahydro-1,4,4,7A-Tetramethyl-1H-Inden-2-Ol","Oxyhumulinic Acid","Nor-9-Carboxy-Delta9-Thc","Pe(38:4)","3-(4-Hydroxyphenyl)Lactate","Pe(P-18:0/22:6)","Pe(20:5/0:0)","4-Dodecylbenzenesulfonic Acid","Ps(Pge2/24:0)","3-[(3-(2-Carboxyethyl)-4-Methylpyrrol-2-Yl)Methylene]-2-Indolinone","Tyramine Glucuronide","Citric Acid","Gpetn(20:4/18:0)","1-(11Z,14Z-Eicosadienoyl)-Glycero-3-Phosphate","Macrolactin-A","Lysope(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)","Valerenic Acid","Pc(38:3)","Pe(38:5)","Succinic Acid","Lysopi(18:2(9Z,12Z)/0:0)","Lysopc(0:0/18:2(9Z,12Z))","4'-Hydroxyfenoprofen Glucuronide","Momordol","Dihydrojasmonic Acid","Furanogermenone","Adipic Acid","Sabarubicin","(24E)-3Alpha-Acetoxy-15Alpha-Hydroxy-23-Oxo-7,9(11),24-Lanostatrien-26-Oic Acid","Lysope(0:0/18:1(9Z))","(+/-)-1,4-Nonanediol Diacetate","Brassinolide","Phenyl Hydrogen Sulfate","Humulone","Gpetn(20:4/18:1)","Ps(15:0/24:1(15Z))","Gpetn(20:0/18:2)","Triterpenoids","24,24-Difluoro-1Alpha,25-Dihydroxyvitamin D3","Trinexapac-Ethyl","4-Hydroxy-5-(4'-Hydroxyphenyl)-Valeric Acid-4'-O-Sulphate","(+/-)19,20-Dihdpa","3-Epi-6-Deoxocathasterone","Vanillin-4-Sulfate","Menthyl Pyrrolidone Carboxylate","3-(4-Iodophenyl)-2-Mercapto-(Z)-2-Propenoic Acid","Threonic Acid","Carnosic Acid","Varanic Acid","1-(4-O-Beta-D-Glucopyranosyl-3-Methoxyphenyl)-3,5-Dihydroxydecane","Pc(Dime(13,5)/Lte4)","Indinavir","Methylgingerol","Pe(20:1(11Z)/20:3(8Z,11Z,14Z)-2Oh(5,6))","2(3H)-Benzothiazolethione","Pe(38:3)","Canrenone","Spirotaccagenin","Phenyl Beta-D-Glucopyranosiduronic Acid","2,4-Dihydroxybutanoic Acid","3-(3-Indolyl)-2-Oxopropanoic Acid","Hydroquinidine","Genistein 7-Sulfate","Ps(24:1(15Z)/15:0)","3,4-Dihydroxybenzenesulfonic Acid","Stearoyl Lysophosphatidylethanolamine","Cis-Resveratrol 3-O-Glucuronide","Isopropyl Apiosylglucoside","2-Methylhippuric Acid","Alpha-Cyano-3-Hydroxycinnamic Acid","N-Stearoyl Cysteine","P-Cresol Sulfate","Nervonic Acid","Reticulatamol","Pe(40:4)","Carnosol","Ganoderiol H","1-(2,6-Dihydroxy-4-Methoxyphenyl)-3-Phenyl-1-Propanone","Ala-Gly","Precocene Ii","Pc(18:3(9Z,12Z,15Z)/22:0)","Pe(40:5)","Artemisinic Acid","3-Hydroxystigmast-5-En-7-One","Lpe(18:1)","L-Ascorbic Acid 2-Sulfate","Aconitic Acid","Acetylleucine","3-(3-Sulfooxyphenyl)Propanoic Acid","7Z,10Z-Hexadecadienoic Acid","Pe-Nme2(18:0/20:2(11Z,14Z))","Rollidecin D","Nafazatrom","Indole-3-Acetyl-L-Aspartic Acid","Mono(2-Ethylhexyl) Phthalate","5,9-Epidioxy-3-Hydroxyergost-7-En-6-One","2-Phenylethanol Glucuronide","Sterculic Acid","2-Hexadec-7-Enyloctadecanedioic Acid","4-Vinylphenol","Arachidonic Acid","Ichangin 4-Glucoside","Rotundifolone","10-Hydroxy-2E-Decenoic Acid","Nalidixic Acid","Ferulic Acid 4-O-Sulfate","Carene","Equol 4'-O-Glucuronide","Pe(38:6)","Ethyl Tiglate","Lumequic Acid","Penitrem D","(S)-Oleuropeic Acid","2,3-Dihydroxy-5-Methylthio-4-Pentenoic Acid","Ps(15:0/22:0)","Dl-M-Tyrosine","Ancymidol","Vanillylacetone","Trans-2-Hexacosenoic Acid","Menthyl Ethylene Glycol Carbonate","Oleoyl-L-Alpha-Lysophosphatidic Acid","3-Phenylpropionic Acid Sulfate","1-O-Hexadecyl-Sn-Glycero-3-Phosphocholine","4-Hydroxybenzoic Acid","2-Octaprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol","2-Oxoarginine","Lysopi(0:0/18:0)","11,12-Epoxyeicosatrienoic Acid","Coriolic Acid","Dihomo-Alpha-Linolenic Acid","7-Ketodeoxycholic Acid","S-(N,N-Diethylcarbamoyl)Glutathione","Pe(20:3(8Z,11Z,14Z)-2Oh(5,6)/20:1(11Z))","15-Methylprostaglandin E1","Ovalicin","Tyrosyl-Threonine","4-Oxododecanedioic Acid","N-Acetyl-L-Glutamic Acid","(+)-Lysergic Acid","1-O-Acetyl Britannilactone","(+/-)-Pelletierine","L-Threo-3-Phenylserine","Pc(40:6)","Alpha-Tocopheryloxyacetic Acid","Blasticidin S","Gpins(18:0/20:4)","4-Hydroxy-6-Methyl-2-Pyrone","Pe(20:4/0:0)","Pe(P-18:0/20:4)","Lpc(18:3)","Methylnoradrenaline","Coronaric Acid","Apigenin 7-Sulfate","Costunolide","Pantetheine","N-Stearoyl Histidine","Cpa(18:2(9Z,12Z)/0:0)","4-Hydroxyphenylpyruvic Acid","3 Alpha,7 Alpha,26-Trihydroxy-5Beta-Cholestane","5,6-Epoxy,18R-Hepe","Haloxyfop","6-Hydroxy-4-Methoxy-3-(3-Methyl-2-Butenyl)-2-(2-Phenylethenyl)Benzoic Acid","3-Methoxyphenylacetic Acid","Pc(40:7)","Alpha-D-Glucose","11'-Carboxy-Alpha-Chromanol","Erythronolactone","21-Hydroxy-5B-Pregnane-3,11,20-Trione","Enoximone Sulfoxide","Malic Acid","Limocitrin 3-Rhamnoside","(R)-2-Hydroxystearic Acid","Prolyl-Alanine","3,4-Dimethyl-5-Pentyl-2-Furanpentadecanoic Acid","3-Dehydroteasterone","2-Tiglylcarnitine","2-Mercaptobenzothiazole","Bioallethrin","Glabranin","Daphnoretin","Undecanedioic Acid","Methyl 2-(10-Heptadecenyl)-6-Hydroxybenzoate","Lysope(0:0/16:0)","Gpetn(22:6/18:1)","Maleic Acid","2-Deoxycastasterone","Pc(40:8)","2-Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinone","16-Hydroxyhexadecanoic Acid","2-(2-Hydroxyethyl)Phenyl Hydrogen Sulfate","6-(1-Hydroxyethyl)-2,2-Dimethyl-2H-1-Benzopyran","7,4'-Dihydroxy-8-Methylflavan","(All-Z)-7,10,13-Docosatrienoic Acid","(+/-)13-Hpode","Pe(40:7)","10-Hdohe","(3R, 6'Z)-3,4-Dihydro-8-Hydroxy-3-(6-Pentadecenyl)-1H-2-Benzopyran-1-One","(6E,8S,10Z)-8-Hydroxy-3-Oxohexadecadienoic Acid","Pa(8:0/20:4(7E,9E,11Z,13E)-3Oh(5S,6R,15S))","3-Guanidinopropionic Acid","Cis-Solamin","Azelaic Acid","Tetracosanedioic Acid","Belinostat Glucuronide","Isolithocholic Acid","Isocolumbin","2-[4-(Sulfooxy)Phenyl]Acetic Acid","Chlorpheniramine","2-Hydroxy-6-Pentadecylbenzoic Acid","Glucosyl (2E,6E,10X)-10,11-Dihydroxy-2,6-Farnesadienoate","Alpha-Acetyllysine","Pe(40:6)","Lubiprostone","2,6,10,10-Tetramethyl-1-Oxaspiro[4.5]Decan-6-Ol","Daidzein","Phosphatidylethanolamine Alkyl 20:0-20:4","Chenodeoxycholylphenylalanine","12-Hepe"],"additional_accession":[]},"is_claimable":false,"name":"The effect and mechanism of gut flora metabolite deaminotyrosine on chronic inflammatory pain","description":"This study focuses on deaminotyrosine DAT, a metabolite of gut flora, and systematically investigates its effect on chronic inflammatory pain as well as the underlying mechanism. The research takes high-fat diet HFD as a key entry point for the background, as HFD often leads to an imbalance in the structure of gut flora. This imbalance may affect the production of intestinal metabolites including DAT, and thereby be associated with the occurrence and development of chronic inflammatory pain
","dates":{"publication":"2026-08-10","submission":"2025-10-26"},"accession":"MTBLS13221","cross_references":{}}