At the same time, the metabolites were identified by searching database, and the main databases were the HMDB (http://www.hmdb.ca/), Metlin ( https://metlin.scripps.edu/) and the self-compiled Majorbio Database (MJDB) of Majorbio Biotechnology Co., Ltd. (Shanghai, China).
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - negative - reverse phase","Liquid Chromatography MS - positive - reverse phase"],"chromatography_protocol":["The LC-MS/MS analysis of sample was conducted on a UHPLC-Q Exactive HF-X system
equipped with an ACQUITY HSS T3 column (100 mm × 2.1 mm i.d., 1.8 μm; Waters, USA) at
Majorbio Bio-Pharm Technology Co. Ltd. (Shanghai, China). The mobile phases consisted of
0.1% formic acid in water:acetonitrile (2:98, v/v) (solvent A) and 0.1% formic acid in acetonitrile
(solvent B). The flow rate was 0.40 mL/min and the column temperature was 40. The injection
volume was 5 μL.
"],"publication":["Dietary leucine restriction remodels the gut microbiota and serum glycerophospholipids to combat obesity."],"submitter_affiliation":["Peking University"],"submitter_name":["Duo Keai"],"organism_part":["serum"],"technology_type":["mass spectrometry"],"disease":[""],"extraction_protocol":["100 μL liquid sample was added to a 1.5 mL centrifuge tube with 800 μL solution
(acetonitrile: methanol = 1:1(v:v)) containing four internal standards (0.02 mg/mL
L-2-chlorophenylalanine, etc.) to extract metabolites. The samples were mixed by vortex for 30 s
and low-temperature sonicated for 30 min (5°C, 40 KHz). The samples were placed at -20°C for
30 min to precipitate the proteins. Then the samples were centrifuged for 15 min (4°C, 13000 g). The supernatant was removed and blown dry under nitrogen. The sample was then re-solubilized
with 100 µL solution (acetonitrile: water = 1:1) and extracted by low-temperature ultrasonication
for 5 min (5°C, 40 KHz), followed by centrifugation at 13000 g and 4°C for 10 min.The
supernatant was transferred to sample vials for LC-MS/MS analysis.
"],"organism":["Mus musculus"],"data_transformation_protocol":["The pretreatment of LC/MS raw data was performed by Progenesis QI (Waters Corporation, Milford, USA) software, and a three-dimensional data matrix in CSV format was exported. The information in this three-dimensional matrix included: sample information, metabolite name and mass spectral response intensity. Internal standard peaks, as well as any known false positive peaks (including noise, column bleed, and derivatized reagent peaks), were removed from the data matrix, deredundant and peak pooled.
"],"study_factor":["Group"],"metabolights_link":["https://www.ebi.ac.uk/metabolights/MTBLS13281"],"submitter_email":["keaiduoduo998@126.com"],"sample_collection_protocol":["Serum samples from the NCD, HFD, and F. rodentium intervention groups (n=10 per group) were subjected to non-targeted metabolomic analysis. Metabolites were extracted from 100 μL serum with 400 μL acetonitrile: methanol (1:1, v/v) containing 0.02 mg/mL L-2-chlorophenylalanine (internal standard). After vortexing, sonication, protein precipitation (-20 °C), and centrifugation (4,000 xg, 15 min, 4°C), the supernatant was dried under nitrogen and reconstituted in 100 μL acetonitrile: water (1:1, v/v) for LC-MS/MS analysis.
"],"omics_type":["Metabolomics"],"study_design":["Gut microbiota","Obesity","Leucine restriction","Glycerophospho-N-oleoyl ethanolamine","Faecalibaculum rodentium"],"curator_keywords":["Gut microbiota","Obesity","Leucine restriction","Glycerophospho-N-oleoyl ethanolamine","Faecalibaculum rodentium"],"mass_spectrometry_protocol":["MS conditions:
The UHPLC system was coupled to a UHPLC-Q Exactive HF-X system Mass Spectrometer
equipped with an electrospray ionization (ESI) source operating in positive mode and negative
mode. The optimal conditions were set as followed: source temperature at 400 ; sheath gas flow
rate at 40 arb; Aux gas flow rate at 10 arb; ion-spray voltage floating (ISVF) at -2800V in negative
mode and 3500V in positive mode, respectively; Normalized collision energy , 20-40-60V rolling
for MS/MS. Data acquisition was performed with the Data Dependent Acquisition (DDA) mode. The detection was carried out over a mass range of 70-1050 m/z.
"],"metabolite_name":["Crassostrea Secocarotenoid","PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","4-Hydroxynonenal","1-Nonadecanoyl-glycero-3-phosphoethanolamine","p-Mentha-1,3,5,8-tetraene","Corticosterone","Arachidic acid","3(2H)-Pyridazinone","2-Hydroxybenzaldehyde","PE(16:0/20:2(11Z,14Z))","Eicosapentaenoic acid ethyl ester","Geranylacetone","Coniferyl alcohol","Ectoine","Lumirubin","L-Threonine","N-di-Demethyl roxithromycin","o-(2-fluoroethyl)-l-tyrosine","Cyclopamine","Quinoline","Glaucarubol 15-O-beta-D-glucopyranoside","Kynurenic acid","8-Amino-7-oxononanoic acid","beta-Alanine","L-Histidine","5''-Methylthioadenosine","6-Methylpteridine-2,4-diamine","L-Leucine","Chlorobenzene","Triflumuron","PC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:0)","6-Hydroxyhexanoic acid","2-Azaspiro[4.5]decan-3-one","Citrulline","Niacinamide;Nicotinamide ascorbate","o-Ethyltoluene","L-Proline","Polyoxyethylene 40 monostearate","2-Methylbutyroylcarnitine","Deca-2,5,8-trienedioylcarnitine","Styrene","Petrosaspongiolide m","3-Hydroxyanthranilic acid","(1R,3S)-3-(6-Aminopurin-9-yl)cyclopentan-1-ol","Dihydroceramide","Pelargonidin 3-sophoroside","4-Hydroxybenzaldehyde","4-Hydroxyproline","PIP(PGF1alpha/16:0)","Arachidonoylcarnitine","PE(20:3(5Z,8Z,11Z)/18:1(11Z))","Butyrylcarnitine","Glutaric acid","Nicotine glucuronide","L-Tryptophan","alpha-Bisabolol oxide C","4-Methyl-1-pentene","Diaminopimelic acid","alpha-Ionol O-[arabinosyl-(1|right|6)-glucoside]","Serotonin","Annoglacin A","D-manno-2-Heptulose","LysoPC(18:1(9Z)/0:0)","Solutol HS 15","gamma-Glutamylphenylalanine","4-Methylstyrene","PE(20:4(5Z,8Z,11Z,14Z)/18:0)","Hippuric acid;2-Methylhippuric acid;Hippuric acid","Pentaethylene glycol","Pyrroline","Pantothenic acid;3-[[(2S)-2,4-Dihydroxy-3,3-dimethylbutanoyl]amino]propanoic acid","Threonylaspartic acid","4-Hydroxy-3-methoxybenzenemethanol","L-Valine","N-Methyl-L-proline","Uracil","2-Amino-2-methyl-1-propanol","Indolelactic acid","1-Benzylimidazole","2-(Methylthio)benzothiazole","Creatine","Sphingosine 1-phosphate","Bioadykinin Fragment 1-5","(E)-5,8-Megastigmadien-4-one","S-(2-Carboxyethyl)-L-cysteine","(S)-Menthone 8-thioacetate","(R)-1-O-[b-D-Apiofuranosyl-(1|right|2)-b-D-glucopyranoside]-1,3-octanediol","Diisopropylethylamine","Acetoacetic acid","Oxidized glutathione;Cytidine 2'',3''-cyclic phosphate","Fucoxanthinol","Dihydro-alpha-ionone","1,5-Isoquinolinediol","Biliverdin","hydroxytetradecadienyl-l-carnitine","Candidin","25-Acetylvulgaroside","Olpadronic acid","Gentamicin C","S-Phenylmercapturic acid","Eriojaposide B","12-Methyltridecanoic acid","Guanidinosuccinic acid","(1(10)E,4a,5E)-1(10),5-Germacradiene-12-acetoxy-4,11-diol","Perfluorooctanesulfonyl fluoride","Spermine","Myristic acid","L-Thyronine","Anisole","5-(delta-Carboxybutyl)homocysteine","Cyclohexane","Alpha-linolenyl carnitine","PC(18:0/20:4(5Z,8Z,11Z,14Z))","Spinacetin 3-O-(2''''-feruloylglucosyl)(1|right|6)-[apiosyl(1|right|2)]-glucoside","N-Acetyl-DL-phenylalanine","PC(14:0/20:1(11Z))","Indole","Kobusone","PC(18:2(9Z,12Z)/18:2(9Z,12Z))","trans-beta-Farnesene;beta-Farnesene","3,5,5-Trimethyl-2-cyclohexen-1-one","Angiotensin IV","Dibutyl decanedioate","Corchoionoside B","PC(20:3(5Z,8Z,11Z)/20:3(5Z,8Z,11Z))","Pyridinoline","Isoindoline","PC(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","L-Carnitine","N6,N6,N6-Trimethyl-L-lysine","Diethanolamine","Cysteinyl-Glutamine","Metenamine","Thymine;6-Dehydrotestosterone glucuronide;Thymine","p-Octopamine","PC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/16:0)","Histidylhydroxyproline","Adenosine monophosphate","1-(3-Carboxypropylcarbamoyl)-5-fluorouracil","Heptaethylene glycol monododecyl ether","N-Acetyltryptophan","Shanzhiside","Dilinoleoylphosphatidylcholine","Pipecolic acid;L-Pipecolic acid;Pipecolic acid","Indolepyruvate","PE(14:0/22:2(13Z,16Z))","2-Hydroxycinnamic acid","PE(14:0/22:4(7Z,10Z,13Z,16Z))","L-Tyrosine","trans-Hexadec-2-enoyl carnitine","PE(20:1(11Z)/18:3(6Z,9Z,12Z))","Squamocin L","Myotoxin A","Didanosine","(R)-Menthofuran","Kenacourt","Benzoic acid","Beta-Guanidinopropionic acid","L-Phenylalanine","Phenylacetic acid","Alanine-betaxanthin","Riesling acetal","Benzenebutanoic acid, alpha-(acetylamino)-2-amino-gamma-oxo-","O-Acetylserine","PC(14:0/20:2(11Z,14Z))","4-Trimethylammoniobutanoic acid","16-Hydroxyhexadecanoic acid","1-Methylhistidine;3-Methylhistidine;1-Methylhistidine","Z-Lly-fmk","Spermidine","3-Hydroxyphloretin 2''-O-xylosyl-glucoside","Sphingosine","DG(11M5/13M5/0:0)","2-Aminonaphthalene","6-Methylnicotinamide","Tyramine","gamma-Glutamylleucine","Myristoylcarnitine","Asiaticoside B","LysoPE(20:4(5Z,8Z,11Z,14Z)/0:0)","(7Z)-Octadec-7-enoylcarnitine","PE(20:5(5Z,8Z,11Z,14Z,17Z)/18:1(11Z))","D-Kynurenine","Glyceryl monolinoleate","3-Cyanoalanine","12-Hydroxydodecanoic acid","Urocanic acid;Trans-urocanate","1,3-Butadiene","Propionylcarnitine","Cucurbitacin C","Sebacic acid","Eriodictyol 7-(6-trans-p-coumaroylglucoside)","L-Methionine","Aspartylphenylalanine","Buprenorphine","4-Imidazolone-5-propionic acid","3-Hexenedioic acid","Glycerophosphocholine","Geranyl acetate","Platelet-activating factor","Suberic acid","3,4-Dihydro-5-propanoyl-2H-pyrrole","PC(20:4(5Z,8Z,11Z,14Z)/16:0)","PC(14:0/20:0)","Penitrem D","PE(18:1(11Z)/18:1(11Z))","7'',8''-Dihydro-8''-hydroxycitraniaxanthin","Penitrem B","Perphenazine decanoate","1-Methylnicotinamide","Indoleacetic acid","Acetophenone","1,3,5-Trihydroxybenzene","PC(22:5(4Z,7Z,10Z,13Z,16Z)/16:1(9Z))","Policapram","Adenosine;9-Arabinofuranosyladenine","Creatinine","3-Acetyl-2,5-dimethylfuran","urea glutamate","PC(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z))","Butanal","Hexanal","Decanoylcarnitine","2-Methylpyridine","(-)-Epigallocatechin","6a,12a-Dihydroxylithocholic acid","Quinic acid","Choline","(2E)-Decenoyl-ACP","N-Acetyl-L-alanine","Polyglycerol esters of fatty acids","Cibaric acid","1-docosene","Hexaethylene glycol","PC(20:5(5Z,8Z,11Z,14Z,17Z)/18:2(9Z,12Z))","Tanacetol B","ubiquinone-8","Aspartylhydroxyproline","Palmitic amide","Arachidoyl Ethanolamide","Velaresol","PE(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","4-Pentenoic acid","L-Isoleucine","Gymnodimine","3''-AMP","Benzophenone","S-Allylcysteine","RHODAMINE 6G","(3beta,5beta,8beta,22E,24xi)-Ergosta-6,22-diene-3,5,8-triol","Indoline","Betaine","Tramadol","Indole-3-carboxaldehyde","1,4-Ipomeadiol","milbemycin beta3","o-Tyrosine","beta-Mercaptoethanol","o-(2-fluoroethyl)tyrosine","10-Methylpentadecanoylcarnitine","5,7alpha-Dihydro-1,4,4,7a-tetramethyl-4H-indene","2-Aminopurine","Benzaldehyde","1,3-Dihydro-(2H)-indol-2-one","(6,12)-11-Hydroxyhexadecadienoylcarnitine","Floionolic acid","Adrenochrome","Palmitoylcarnitine","Phosphorylcholine","Phenylalanylarginine","1-Methylhistidine;3-Methylhistidine;3-Methylhistidine","LysoPC(17:0/0:0)","PC(20:4(5Z,8Z,11Z,14Z)/18:0)","anthralin","Histamine","Dmap-ethyl-paf","PC(18:2(9Z,12Z)/20:5(5Z,8Z,11Z,14Z,17Z))","Chenodeoxycholylarginine","Dimethyl sulfoxide","Cucurbic acid","Isoquinoline","Nitrosobenzene","L-Lysine","Nonadecanoic acid","N-Methyl-D-aspartic acid","2-Linoleoyl Glycerol","alpha-Methylene-gamma-butyrolactone","S-Ethyl dipropylthiocarbamate","3,4-Dihydroxyhydrocinnamic acid","8-Deoxy-11-hydroxy-13-chlorogrosheimin","Ansamitocin P-3","PE(18:3(6Z,9Z,12Z)/22:4(7Z,10Z,13Z,16Z))","Nutriacholic acid","Azelaic acid","(11R,16S)-misoprostol","SM(d18:1/16:0)","2,3-Butanediol","(2E,4E)-2,4-Hexadienoic acid","Mactraxanthin","PC(18:1(9Z)/14:0)","2-Cyclohexylidenecyclohexanone","Galarubicin","N1-Methyl-4-pyridone-3-carboxamide","2-Aminobenzoic acid","PC(14:1(9Z)/20:1(11Z))","Piperidine","alpha-D-Glucose","2-(L-Menthoxy)ethanol","2-Ethylpentanedioylcarnitine","Colforsin daropate","4-Chloro-L-phenylalanine","MG(18:1(9Z)/0:0/0:0)","Acetyl tributyl citrate","4,5-Dihydroorotic acid","Dodeca-6,8,10-trienoylcarnitine","Asi-222","Deoxycholylarginine","APC","Phenethylamine glucuronide","5-(3-Pyridyl)-2-hydroxytetrahydrofuran","Sarcosine","gamma-Terpinene","LysoPC(18:3(9Z,12Z,15Z)/0:0)","Dihydrocarvone","3-(6-Aminopurin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol","Tobramycin","2-Aminoacetophenone","Glutamyltryptophan"],"additional_accession":[]},"is_claimable":false,"name":"Dietary leucine restriction remodels the gut microbiota and serum glycerophospholipids to combat obesity","description":"Abstract
Background The gut microbiota mediates dietary impacts on host metabolism, but the roles of specific amino acids remain elusive. We investigated the mechanism by which dietary leucine restriction combats obesity.
Methods Combining Mendelian randomization in humans with intervention studies in high-fat diet mice, we assessed leucine restriction's effects. Mechanisms were probed via fecal microbiota transplantation, 16S rRNA sequencing, and serum non-targeted metabolomics.
Results Human genetics suggested a causal role for leucine in obesity. In mice, leucine restriction ameliorated metabolic disorders, and this effect was transferable by microbiota transplantation. We identified Faecalibaculum rodentium (F. rodentium) as a key enriched bacterium. Monocolonization with this strain replicated the anti-obesity benefits, which were linked to upregulated levels of the metabolite glycerophospho-N-oleoyl ethanolamine (GNOE), which correlated negatively with obesity phenotypes and was implicated in lipid and bile acid metabolism.
Conclusion Dietary leucine restriction confers metabolic benefits by enriching the gut microbe F. rodentium, which modulates host glycerophospholipid metabolite GONE to reduce obesity.
Key words: Obesity; Leucine restriction; Gut microbiota; Faecalibaculum rodentium; Glycerophospho-N-oleoyl ethanolamine
","dates":{"publication":"2025-11-07","submission":"2025-11-07"},"accession":"MTBLS13281","cross_references":{"HMDB":["HMDB0039110","HMDB0243607","HMDB0303973","HMDB0000488","HMDB0029799","HMDB0010728","HMDB0034160;HMDB0034844;LMFA07010812;LMPR0102010015","HMDB0030396","HMDB0039761","HMDB0002327;LMFA01170014","HMDB0244272","HMDB0006111;HMDB0244455;LMFA03060088","HMDB0013633;LMFA03060019","HMDB0035113","HMDB0062452","HMDB0304033","HMDB0243883","HMDB0244631","HMDB0243972","HMDB0030524","HMDB0001294","HMDB0000360","HMDB0040198","HMDB0166723","HMDB0006756","HMDB0001231","HMDB0033580","HMDB0031412","HMDB0034423","HMDB0031031","HMDB0000617","HMDB0000407;LMFA01050478","HMDB0000317","HMDB0000008;PW_C000004","HMDB0000424","HMDB0031057","HMDB0255446","HMDB0012455","HMDB0061649","HMDB0006894","HMDB0000359","HMDB0002390","HMDB0041527","HMDB0304128","HMDB0000444","HMDB0030003","HMDB0002466","HMDB0000413","HMDB0000350","HMDB0034422","HMDB0304914","HMDB0059969","HMDB0000491;PW_C000373","HMDB0000555","HMDB0241659","HMDB0036172","HMDB0246328","HMDB0060385","HMDB0061877","HMDB0059915","HMDB0029306","HMDB0059981","HMDB0061052","HMDB0000017;PW_C000011","HMDB0241656","HMDB0001087","HMDB0030993","HMDB0247056","HMDB0031173","HMDB0039439","HMDB0000391","HMDB0062243","HMDB0006940;HMDB0062434;HMDB0006940","HMDB0094711","HMDB0000034;PW_C000024","HMDB0028695","HMDB0000462","HMDB0038196","HMDB0004670","HMDB0248390","HMDB0031390","HMDB0001043;LMFA01030001;PW_C000821","HMDB0249363","HMDB0248628","HMDB0028757","HMDB0028763","HMDB0035473","HMDB0041225","HMDB0035155;HMDB0005812","HMDB0003797","HMDB0034739","HMDB0257951","HMDB0249899","HMDB0242403","HMDB0000653;LMST05020016","HMDB0000619;LMST04010001;PW_C000480","HMDB0242371","HMDB0250270","HMDB0303125","HMDB0250290","HMDB0000094;PW_C000063","HMDB0030997","HMDB0041454","HMDB0304329","HMDB0000626;LMST04010040;PW_C000487","HMDB0242435","HMDB0242413","HMDB0242420","HMDB0244716","HMDB0000660","HMDB0006355","HMDB0255966","HMDB0061864","HMDB0033601","HMDB0251511","HMDB0002183;PW_C001472","HMDB0244316","HMDB0000623;LMFA01170009","HMDB0012937","HMDB0015109","HMDB0001999;PW_C001337","HMDB0033778","HMDB0002899","HMDB0251762","HMDB0038661","HMDB0000349","HMDB0031233","HMDB0014825","HMDB0000134;PW_C000088","HMDB0011741","HMDB0037781","HMDB0032104","HMDB0000625","HMDB0000620;LMFA01170109","HMDB0252812","HMDB0028823","HMDB0028827","HMDB0000139;PW_C000090","HMDB0304685","HMDB0037265","HMDB0000672;LMFA01170022","HMDB0000701","HMDB0011719","HMDB0000755","HMDB0028868","HMDB0001190","HMDB0000682","HMDB0302972","HMDB0000717","HMDB0253757","HMDB0034267","HMDB0029387","HMDB0000161;PW_C000105","HMDB0000191;PW_C000123","HMDB0034266","HMDB0000665;LMFA01050381","HMDB0014511;LMST02030119","HMDB0000148","HMDB0000641;PW_C000500","HMDB0000187;PW_C000120","HMDB0010382","HMDB0010383","HMDB0010384","HMDB0010386","HMDB0010387","HMDB0010390","HMDB0010391","HMDB0010393","HMDB0010395","HMDB0010397","HMDB0010404","HMDB0011473","HMDB0011474","HMDB0011475","HMDB0011477","HMDB0011478","HMDB0011487","HMDB0011489","HMDB0011496","HMDB0240602","HMDB0240600","HMDB0240597","HMDB0061690","HMDB0060626","HMDB0000156;PW_C000101","HMDB0031864","HMDB0030326","HMDB0254656","HMDB0029804","HMDB0254845","HMDB0002000","HMDB0245646","HMDB0001250","HMDB0255052","HMDB0006029","HMDB0011756","HMDB0011745","HMDB0000512","HMDB0000866;HMDB0244966","HMDB0255420","HMDB0039102","HMDB0242014","HMDB0002368","HMDB0001015","HMDB0015187","HMDB0255642","HMDB0255734","HMDB0000819;PW_C000654","HMDB0002055","HMDB0000782;LMFA01170029","HMDB0304442","HMDB0000786;HMDB0002818;HMDB0000786","HMDB0000220;LMFA01010001;PW_C000145","HMDB0301801","HMDB0007980","HMDB0007982","HMDB0007984","HMDB0008039","HMDB0008048","HMDB0008057","HMDB0289417","HMDB0289522","HMDB0038568","HMDB0011686","HMDB0011635","HMDB0008835","HMDB0008842","HMDB0008843","HMDB0008844","HMDB0008943","HMDB0008946","HMDB0008994","HMDB0009045","HMDB0009090","HMDB0009225","HMDB0261551","HMDB0284852","HMDB0011352","HMDB0005780","HMDB0285371","HMDB0256231","HMDB0002080","HMDB0060015","HMDB0000821","HMDB0000205;PW_C000131","HMDB0030447","HMDB0001429;PW_C001104;PW_C097007","HMDB0009789","HMDB0009815","HMDB0301836","HMDB0000237;LMFA01010003;PW_C000159","HMDB0002656","HMDB0030963","HMDB0257108","HMDB0032876","HMDB0001900","HMDB0257483","HMDB0035512","HMDB0030048","HMDB0000258;PW_C000177","HMDB0000251;PW_C000171","HMDB0000872;LMFA01170018","HMDB0258926","HMDB0000943","HMDB0029073","HMDB0003252;PW_C001820","HMDB0000273","HMDB0000958","HMDB0035495","HMDB0029082","HMDB0037608","HMDB0000888;LMFA01170007","HMDB0000289;PW_C000195","HMDB0032590","HMDB0038361","HMDB0038798","HMDB0242321","HMDB0242329","HMDB0062225","HMDB0029581;LMFA01030100","HMDB0038353","HMDB0241486","HMDB0241531","HMDB0034671","HMDB0032798","HMDB0036089;LMPR0102090020","HMDB0037386","HMDB0243786","HMDB0013675","HMDB0041792","HMDB0061918","HMDB0030471","HMDB0244237","HMDB0241914","HMDB0002059","HMDB0031072","HMDB0006294","HMDB0243836","HMDB0062602","HMDB0000001;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