MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/m_MTBLS13369_LC-MS_negative_reverse-phase_metabolite_profiling-1_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/a_MTBLS13369_LC-MS_negative_reverse-phase_metabolite_profiling-1.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/s_MTBLS13369.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047722a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047704a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047697a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/MWY22236601a_mix04_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047719a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047716a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047688a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047685a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/MWY22236601a_mix03_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047695a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047705a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047702a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047689a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047686a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047691a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047683a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047708a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047717a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047726a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047684a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047723a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/MWY22236601a_mix01_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047698a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/MWY22236601a_mix02_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047703a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047706a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047682a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047700a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047724a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047699a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047701a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047715a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047696a_N.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369/FILES/DERIVED_FILES/T22047727a_N.mzXMLprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13369<p>HMDB/METLIN match; VIP+t-test; ROC used.</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phase<p>UPLC-HSS T3 column; FA-water/ACN gradient.</p>Bacteroides uniformis-Induced Gut Dysbiosis Promotes High Myopia Progression via Pyroglutamic Acid.Dan WenCentral south universitybloodmass spectrometry<p>Plasma extracted with ACN/MeOH; QC and blanks used.</p>Homo sapienshttps://www.ebi.ac.uk/metabolights/MTBLS13369Dan Wen. Central South University, Changsha, Hunan, China. wendan@csu.edu.cn.Zhao Liting. Central South University, Changsha, Hunan, China. wendan@csu.edu.cn.<p>XCMS processing; SVR correction; log scale.</p>Groupwendan@csu.edu.cn<p>Blood was collected from the antecubital vein using EDTA-containing anticoagulant tubes (Becton, Dickinson and Company, United States), allowed to stand at room temperature for 30 minutes, and then centrifuged at 2000 rpm for 10 minutes. The plasma was separated and stored at -80°C.</p>MetabolomicsPlasmaMetabolomicsglutathione metabolismHigh myopiaPlasmaMetabolomicsglutathione metabolismHigh myopia<p>LC-MS in positive mode; mzML data acquired.</p>Chalepensin(2S,3R,4R,5S)-2-[(3S,5S,8R,9S,10S,13S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-5,6-dimethylheptane-3,4-diolAspartylcysteineArachidic acidZinniolPyrocatecholJanthitrem EFormylanthranilic acid(¡À)-TryptophanLysoPA(24:1(15Z)/0:0)L-Rhamnulose 1-phosphateBenodanilSucralose26-Hydroxycholesterol 3-sulfateXanthurenic acid 8-methyl etherDemethylspheroidenePhyscionmethyl (3R,21S,22S)-16-ethenyl-11-ethyl-12,17,21,26-tetramethyl-4-oxo-22-[3-oxo-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enoxy]propyl]-7,23,24,25-tetrazahexacyclo[18.2.1.15,8.110,13.115,18.02,6]hexacosa-1(23),2(6),5(26),7,9,11,13,15,17,19-decaene-3-carboxylate6-DeoxodolichosteronePhosphoenolpyruvateChloramphenicol 3-acetateKynurenic acid3-Indoleacrylic acidIndole-5-carboxylic acidFenpiclonilTyr-Gln-Ile-Arg{[(2R,3S,4R,5R)-3,4-dihydroxy-5-[(formamidomethanimidoyl)amino]oxolan-2-yl]oxy}phosphonic acidalpha-Ketoisovaleric acidThymidine-5'-triphosphateGanoderic acid HValdecoxib3-Hydroxynonyl acetate2,3-bis(Acetyloxy)propyl icosanoateGlyzaglabrinErythrinasinate A2-Propenamide, 2-cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-Flindersine{8-[2-(acetyloxy)propan-2-yl]-2-oxo-2H,8H,9H-furo[2,3-h]chromen-9-yl}oxidanesulfonic acidUridine-5'-monophosphatePheophorbide aHippomane factor M11,7-Bis(4-hydroxyphenyl)-5-methoxy-3-heptanoneMethyl beta-D-galactopyranoside13-(beta-D-glucosyloxy)docosanoic acid1-eicosanoyl-2-(11Z-eicosenoyl)-sn-glycero-3-phosphoethanolamine4-Hydroxy-2-methylquinoline4-ChlorophenolSulfachlorpyridazine3-Hydroxydodecanoic acidTyr-Thr-Gln-ArgNordihydrocapsiate[2-hydroxy-3-[(9Z,12Z)-octadeca-9,12-dienoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphateN-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]octadecanamide7-(9Z-hexadecenoyloxy)-hexadecanoic acidMS-PpohF-Amidine (trifluoroacetate salt)SulfapyridineTos-Ph-CH2ClEstradiolD-MannoseWortmannin from Penicillium funiculosumArginineS-Nitroso-N-acetyl-DL-penicillamineLorazepamPrimary fluorescent chlorophyll cataboliteSalsalate2-Hydroxy-2-phenylpropanoic acidGlutathioneFFA(12:1)3-(6-hydroxy-7-methoxy-2H-1,3-benzodioxol-5-yl)propanoic acidObeticholic acidKaempferolSulochrinCinnabarinic acidFerulic acidEstrone glucuronideTestosteroneO-Desmethylnaproxen2-Ethyl-3-methylpyrazine, 9CINitazoxanideArabinonic acidChorismic acidIndole-3-propionic acidHis-Phe-Ile-LysCinchophenD-phenylalanineVidarabine4-[4-(2,3-Dihydro-1,4-benzodioxin-6-YL)-3-methyl-1H-pyrazol-5-YL]-6-ethylbenzene-1,3-diolRhein15-epi Travoprost2-Propylglutaric acid[6,12-bis(3,4-dihydroxyphenyl)-8-hydroxy-4-oxo-3,11-dioxatricyclo[8.4.0.0(2),]tetradeca-1(10),2(7),8-trien-13-yl]oxidanesulfonic acid[5-(Aminomethyl)-3-furyl]methyl diphosphate4-(pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine3-Mercaptopyruvic acidSphingosine 1-phosphate17-phenyl trinor PGF2 diethyl amideIndolylmethyl glucosinolateUrobilinogen5-Chloro-3-(4-methylsulfonylphenyl)-2-pyridin-3-ylpyridineSaccharinO-Phospho-L-tyrosine3-MethylxanthineAcetylglycinePermanganateN-¦Ã-Acetyl-N-2-Formyl-5-Methoxykynurenamine2,3-dinor FluprostenolMethylprednisolone hemisuccinateTriton X-1003-Phenylbutyric acidGlycylglycylglycineErgocalciferolThymopentin7-Methylpyrido(3,4-c)psoralenLoganinHelveticoside5,6-EET2,4-Di-tert-butylphenolEupachloroxinAlprazolam3-carboxy-2,3-dihydroxypropanoate2,4-Dipropylthiazole15-oxoETEL-Glutaminyl-L-serineCarglumic acidDotriaconta-14,17,20,23,26,29-hexaenoic acid16-Glucuronide-estriolPregnenolone sulfateAcetylvalerenolic acidOxalacetic acidRhamnoseBergaptolArachidonoyl SerotoninLeu-Asn-Arg-GluThiosulfuric acid3,4-Dihydrospheroidene3-Amino-6H-dibenzo[b,d]pyran-6-onetrans-Coumaryl acetateZizyphine AMonuronAspartylmethionineIndole-3-carbinolFusidic acidCombretum caffrumHypaconitineMoracin MTrimetaphosphoric acidRutaecarpineTCE epoxideIsocitric acidPregn-4-ene-3,20-dione, 17-(acetyloxy)-LPE(22:6/0:0)Fumonisin b2D-ErythroseWharangin6-deoxy-6-sulfo-D-fructofuranose 1-phosphategamma-GlutamylglutamateN,N'-Diacetylhydrazinealpha-HydroxytriazolamMethazolamideaurachin C epoxideFosphenytoin1-Palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholinePectacholAzobenzene-4-sulfonic acidHomocitrulline2-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylateIndolepyruvateUric acid[(3S,3aR,4S,6S,6aS,8R,9R,9aR,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-2-oxo-4,5,6a,7,8,9,9a,9b-octahydroazuleno[4,5-b]furan-8-yl] 2-methylbutanoate1-Naphthylacetic acidArginyl-glycyl-aspartic acidOxoadipic acidAcetoacetyl-coenzyme aPhorbol caprate, tiglatePhorbol 12-myristate 13-acetateAcylated phloroglucinol2-Naphthoxyacetic acid7-(6-Oct-1-enyl-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl)hept-5-enoic acidAerophobin 1Methy Indole-3-AcetateGanoderiol CDesthiobiotinKaempferideRiesling acetalTraumatic acidPalmitic acidEthacrynic acidTiocarlideErythritolFirefly luciferin2-O-alpha-mannosyl-D-glyceratePhytanic acidGly-Ala-Pro-Met-Phe-Val-NH2MethotrexateN-(4-aminobutyl)-3-(4-hydroxyphenyl)propanamide10-Hydroxycamptothecin2-Dodecylbenzenesulfonic acid5-Methyl-5,6,7,8-tetrahydromethanopterinFlibanserinN-Acetylproline2,2-Bis(4-hydroxyphenyl)propanoic acidMevalonate 5-phosphate4'-Hydroxywarfarin2'',6''-Di-O-acetylononingamma-GlutamylcysteineRibonolactone2-Methyl-3-(pyrimidin-2-YL)propanoic acid2',6'-Dihydroxyacetophenone(2R,6S,7R,9R,12S,16S)-6-hydroxy-15-[(1S)-1-[5-(hydroxymethyl)-4-methyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-2,16-dimethyl-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadec-4-en-3-one3,4-DihydroanhydrorhodovibrinGlycerophospho-N-Arachidonoyl EthanolamineLupulone(2R,3S,5S,8R,9S,10S,13S,17R)-17-[(2S,3R,4R,5S)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-2,3-diolHedamycinMethsuximide1,2,4,5,7,8-Hexathionane5-BromopyrimidineSodium glucuronate2,3-Bis(4-hydroxyphenyl)-1,2-propanediolGanolucidic Acid ED-Allopyranose 6-phosphate19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5S,7S,9R,11,15R,hexamethyl-8-oxo-2E,10E,12E,16Z,18E-nonadecapentaenoic acidOxidized Watasenia luciferinPyroglutamic acidLeu-Asp-Val-Lys-HisDanthronTyrMe-Abu-OH2-Chloro-4-biphenylolLonchocarpol AD-Sorbitol-6-phosphate4-Methylumbelliferyl glucuronide8-BromoadenosineNCGC00380642-01_C26H34O7_1,1,5a,7a,9,11b-Hexamethyl-7-methylene-3,8,11-trioxo-3,5a,5b,6,7,7a,8,9,11,11a,11b,12,13,13a-tetradecahydro-1H-isochromeno[7,8-g][2]benzoxepin-12-yl acetateFarnesyl phosphate3-alpha,20-alpha-Dihydroxy-5-beta-pregnane 3-glucuronideLys-Arg-Leu-GluPlatelet activating factorGalNAc(1-3)[Fuc(1-2)]Gal(1-4)GlcNAcSpIsocarboxazidGlutaminyl-arginine(24E)-15alpha-Acetoxy-3alpha-hydroxy-23-oxo-7,9(11),24-lanostatrien-26-oic acid5-Aminopentanoic acid1,1-Dibromo-3-iodo-2-propanoneEtidronic acidDichlorprop-P16-Feruloyloxypalmitic acidTetrachlorosalicylanilide6-({6-[(acetyloxy)methyl]-2,4,5-trihydroxyoxan-3-yl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acidCamptothecinChloroxanthinFosfomycin calciumIndole-3-ylacetyl-myo-inositolAstaxanthin2-Quinoxalinecarboxylic acid5-HydroxymethyluracilFulvestrant(9Z,15Z)-(13S)-12,13-Epoxyoctadeca-9,11,15-trienoic acidBenzo(a)pyrene-9,10-diol1,2-ditetradecanoyl-sn-glycero-3-phospho-N-methylethanolamine4-HydroxymidazolamJasmonic acidChloramben1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1'-myo-inositol)Gluconic acidBis(1-inositol) -3,1'-phosphate 1-phosphate7-MethylxanthineInositolCepharadione B16-Oxohexadecanoic acidSinalbin ASinalbin B3-Carboxy-2-hydroxymuconate semialdehyde[(2S)-2-dodecanoyloxy-3-hydroxypropyl] octadecanoatePhe-Ser-Leu-Phe-AspMaltose2-Chloro-4-methylphenol4-Fluoro-3-nitrobenzotrifluoride6-Hydroxycoumarin2,4-Dinitrotoluenebeta-Cryptoxanthin3-DehydroteasteroneN-Acetylneuraminic Acid(SA)2-Hydroxy-2-methylbutyric acid(1S,2R,5S)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol4-hydroxy-2-methoxy-3-(3-methylbut-2-en-1-yl)benzoic acidN1,N5,N10-Tris-trans-p-coumaroylspermine1-(4-Hydroxy-3-methoxyphenyl)-3-decanoneIndole-3-lactic acidPropofol GlucuronideNb-StearoyltryptamineDaphnoretinO-acetyl-L-serineSedoheptuloseSarcoaldesterol A3-hydroxy-20-oxopregn-5-en-17-yl sulfate3-(2,5-dihydroxy-4-methoxyphenyl)-1-(2,3,4,6-tetrahydroxyphenyl)propane-1,2-dioneAvermectin B1b monosaccharide5-trans U-440694,5-Diaminofluorescein12-Octadec-9-enoyloxyoctadecanoic acid7alpha-Hydroxy-4-cholesten-3-one5-Methoxyindoleacetate17beta-Estradiol 3-(beta-D-glucuronide)2-Keto-L-gulonic acidCYCLOPIAZONIC ACIDTriclopyrDinitrostilbenedisulfonic acid10-Hydroxydecanoic acidDehydrochorismic acid1,1-Dichloro-2-(4-chloro-2,3-dihydroxyphenyl)-2-(4-chlorophenyl)ethyleneThenylchlorcis-Aconitic acid8-Desoxygartanin9-Fluoro-17-hydroxy-2alpha-methylcorticosterone 21-acetate2,5-Dihydro-2,4,5-trimethyloxazole4-Chloro-L-phenylalanineCytidine-5'-diphosphateD-Tagatose1-[(11Z)-octadecenoyl]-2-hexadecanoyl-sn-glycerolPhenol glucuronideaclacinomycin SPsoralenTestosterone glucuronideschisandrin C5-Formyl-2-hydroxyhepta-2,4-dienedioic acid(2R)-3-(5-acetamido-2-hydroxyphenyl)sulfanyl-2-azaniumylpropanoateDaidzein9alpha,15S-Dihydroxy-11-oxothromba-5Z,13E-dien-1-oic acidLolitrem KDichlorpropLucidinLolitrem JfalseBacteroides uniformis-Induced Gut Dysbiosis Promotes High Myopia Progression via Pyroglutamic Acid<p>Plasma samples from subjects with high myopia and those with normal visual acuity were collected for untargeted metabolomic analysis, with the aim of identifying differential plasma metabolites.</p>2025-11-222025-11-22MTBLS13369