The corrected and filtered peaks were then used for metabolite identification by searching a laboratory-built database and integrating public databases (HMDB, https://hmdb.ca/ and KEGG, https://www.kegg.jp/). Finally, metabolites with an identification composite score above 0.5 and a QC sample CV value below 0.3 were extracted. Positive and negative mode results were merged (retaining the substance with the highest identification level and the smallest CV value), resulting in the file all_sample_data.xlsx.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - negative - reverse-phase","Liquid Chromatography MS - positive - reverse-phase"],"chromatography_protocol":["All samples were for two LC/MS methods. One aliquot was analyzed using positive ion conditions and was eluted from T3 column (Waters ACQUITY Premier HSS T3 Column 1.8 μm, 2.1 mm all_fetch_status all_status eb_eye_copy_status eb_eye_entry_counts eb_eye_fetch_status eb_eye_metabolights_complete.xml eb_eye_metabolights_compounds.copy eb_eye_metabolights_compounds.xml eb_eye_metabolights_studies.copy e_fetch_status europe_PMC_metabolights_studies.copy europe_PMC_metabolights_studies.xml head.xml studies.copy study.xml tail.xml thomsonreuters_metabolights_studies.copy thomsonreuters_metabolights_studies.xml 100 mm) using 0.1 % formic acid in water as solvent A and 0.1 % formic acid in acetonitrile as solvent B in the following gradient: 5 to 20 % in 2 min, increased to 60 % in the following 3 mins, increased to 99 % in 1 min and held for 1.5 min, then come back to 5 % mobile phase B witnin 0.1 min, held for 2.4 min. The analytical conditions were as follows, column temperature, 40 °C; flow rate, 0.4 mL/min; injection volume, 4 μL; Another aliquot was using negative ion conditions and was the same as the elution gradient of positive mode.
"],"publication":["Uridine Attenuates Osteoclastogenesis and Ovariectomy Induced Bone Loss by Modulating the PI3K/Akt–FoxO ROS Signaling Axis."],"submitter_affiliation":["The First Affiliated Hospital of Anhui Medical University"],"submitter_name":["Aries Axe"],"organism_part":["cell culture"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["The sample stored at -80 °C refrigerator was thawed on ice. A 500 μL solution (Methanol : Water = 4:1, V/V) containing internal standard was added into the cell sample and vortexed for 3 min. The sample was placed in liquid nitrogen for 5 min and on the dry ice for 5 min, and then thawed on ice and vortexed for 2 min. This freeze-thaw circle was repeated three times in total. The sample was centrifuged at 12000 rpm for 10 min (4 °C). A 300 μL of supernatant was collected and placed in -20 °C for 30 min. The sample was then centrifuged at 12000 rpm for 3 min (4 °C). A 200 μL aliquots of supernatant were transferred for LC-MS analysis.
"],"organism":["Mus musculus"],"data_transformation_protocol":["The raw mass spectrometry data were converted to mzML format using ProteoWizard, and peak extraction, alignment, and retention time correction were performed using the XCMS program. Peaks with a missing rate >50% across sample groups were filtered, and missing values were filled using KNN imputation. Peak areas were corrected using the SVR method.
"],"study_factor":["Treatment"],"metabolights_link":["https://www.ebi.ac.uk/metabolights/MTBLS13394"],"submitter_email":["axearies77@gmail.com"],"sample_collection_protocol":["RAW264.7 murine macrophage cells were obtained from the Cell Bank of the Chinese Academy of Sciences (Shanghai, China). Cells were maintained in DMEM supplemented with 10% fetal bovine serum (FBS) and 1% penicillin–streptomycin, and cultured in a humidified incubator at 37 °C with 5% CO2.
For osteoclast differentiation, RAW264.7 cells were seeded and stimulated with RANKL (50 ng/mL) for 3–5 days, with medium replaced every 2 days. Cells were harvested at indicated time points for metabolomics sample collection.
"],"omics_type":["Metabolomics"],"study_design":["uridine","untargeted metabolites","osteoclast differentiation","osteoporosis"],"curator_keywords":["uridine","untargeted metabolites","osteoclast differentiation","osteoporosis"],"mass_spectrometry_protocol":["All the methods alternated between full scan MS and data dependent MSn scans using dynamic ex- clusion. MS analyses were carried out using electrospray ionization in the positive ion mode and negative ion mode using full scan analysis over m/z 75-1000 at 35000 resolution. Additional MS settings are: ion spray voltage, 3.5 KV or 3.2 KV in positive or negative modes, respevtively; Sheath gas (Arb), 30; Aux gas, 5; Ion transfer tube temperature, 320 °C; Vaporizer temperature, 300 °C; Collision energy, 30,40,50 V; Signal Intensity Threshold, 1*e6 cps; Top N vs Top speed, 10; Exclusion duration, 3s.
"],"metabolite_name":["3-dimethylsulfoniopropionaldehyde","Uridine-5'-diphosphate","Solanidine","Actara","Ser-Thr","2',3'-Cyclic UMP","Ectoine","Cytidine-5'-monophosphate","2-Butyne-1,4-diol","Methapyrilene","Altretamine","gamma-Glutamyl-beta-cyanoalanine","L-Histidine","L-Allothreonine","9-Octadecenal","3-Methylcrotonyl Glycine","4-(Butylamino)benzoic acid","Allyl methyl sulfide","Iminodiacetic acid","Almotriptan","1-Octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)","Nipecotic acid","LPC(18:1/0:0)","Bentazone","2,6-Dimethoxyphenol","3-Methoxybenzyl alcohol","Tosyl-L-lysine chloromethyl ketone","L-Leucyl-L-alanine","N-Ethylglycine","2',6'-Dihydroxy-4'-methoxyacetophenone","4-Hydroxybenzaldehyde","Picolinamide","3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diol","alpha-Camphorene","Chimyl alcohol","1-(1Z-octadecenyl)-sn-glycero-3-phosphocholine","N-Oleoyl-L-Serine","Estradiol","Alpinine","Hordenine","7-Amino-9alpha-methoxymitosane","Arginine","Ricinine","Chloroxine","N-benzoyl-4-methoxyanthranilic acid","gamma-Butyrolactone","(2Z)-2-aminobut-2-enoic acid","N1-acetylspermine","Glutathione","1-Acetylisatin","1,2-Dioctanoyl-sn-glycerol","11-Carbonyl-beta-acetyl-boswellic-acid","alpha-Ergocryptine","4,4'-Sulfonyldiphenol","Fexofenadine","Nicotinate mononucleotide","Hexadecylamine","Pyracarbolid","Caffeic acid","Isodesmosine","3-[(E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol","Adenosine-5'-diphosphate","Proline betaine","MG(18:1/0:0/0:0)","N-Acetyl-S-(N-methylcarbamoyl)cysteine","Oleamide","5-(Aminomethyl)-2-fluorobenzonitrile","Thiazolidine-4-carboxylic acid","Pantothenic acid","Colfosceril palmitate","D-Pyroglutamic acid","1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine","Ursocholic acid","BW-245C","Tetraethylammonium","cis-1,2-Dihydro-3-ethylcatechol","1,3-Diisopropylbenzene","Benzocaine","Arachidonoyl PAF C-16","TG(8:0/8:0/8:0)","Trp-Ile","delta-Hexanolactone","Sulcotrione","Sodium 4-aminosalicylate","Acetoacetic acid","Carnitine C18:2","(3-Hexadecoxy-2-icosa-8,11,14-trienoyloxypropyl) 2-(trimethylazaniumyl)ethyl phosphate","trans-2-Octenoic acid","Phthalic acid","1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine","Maleimide","Dimethylallyl diphosphate","Benzyl alcohol","4-Methoxybenzaldehyde","4beta-Hydroxycholesterol","Apomorphine","2-(((R)-2,3-Dihydroxypropyl)phosphoryloxy)-N,N,N-trimethylethanaminium","4-Oxoniocarbonylbenzoate","¦Ä-Valerolactam","3'-Adenylic acid","2-Phenylglycine","Chenodeoxycholic acid","Ornithine","2-(Octylthio)ethanol","3-Methyladenine","LPC(20:3/0:0)","Cysteinyl-Arginine","Cysteamine","2-(14,15-Epoxyeicosatrienoyl) Glycerol","4-Methylbenzaldehyde","4-Hydroxycyclophosphamide","N-Acetyl-D-Galactosamine","Sambutoxin","Phe-Thr","Isocitric acid","Gln-Asp","Glucuronic Acid","DL-3,4-Dihydroxyphenyl glycol","Aloesin","Adenine sulfate","Adenosine","Adenosine monophosphate","Glucosaminic acid","Allopurinol","L-prolinylglycine zwitterion","Isoprocarb","Terbufos","Uric acid","Cathinone","2-Hydroxycinnamic acid","Aconitic acid","Acitretin","Neolinustatin","2-Hydroxydecanedioic acid","Cyclohexanol, 4-methyl-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-, (1S,3E,4S)-","Chlorphenesin","Noladin ether","Benzoic acid","(-)-Allantoin","Melatonin","L-Phenylalanine","1-Stearoyl-2-docosahexanoyl-sn-glycero-3-phosphocholine","Isoproterenol","Aripiprazole","Modafinil Acid","(1E,6R,11R,13R,14S,15S,19E,21E,23S,27R)-27-hydroxy-23-[(1S)-1-hydroxyethyl]-9,15-dimethylspiro[4,12,17,24-tetraoxapentacyclo[21.3.1.113,16.06,11.06,15]octacosa-1,9,19,21-tetraene-14,2'-oxirane]-3,18-dione","Phenformin","1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine","3-Dehydrosphinganine","1-Nonadecanoyl-2-eicosanoyl-glycero-3-phosphate","Glycidyl oleate","Phytanic acid","N-Acetyl-L-tyrosine","Carnitine C3:0","Glyceryl monostearate","2-Methyl-D-serine","Trp-glu","Tetrahydrocortisone","Phenol, 2-((ethylsulfonyl)methyl)-, methylcarbamate","1-(1Z-hexadecenyl)-2-hexadecanoyl-glycero-3-phosphocholine","Nitrofurazone","Dinex","2-Aminoindan","Phenylethylmalonamide","1-Tetradecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine","Cabergoline","1-Oleoyl-2-myristoyl-sn-glycero-3-phosphocholine","Phenylacetaldehyde","S-Methylglutathione","2,6-Dimethylpyridine","D-threonine","Umbelliferone","Gelsemin","Guanine","Fosetyl","1-Benzyl-3-cetyl-2-methylimidazolium iodide","1-Methylnicotinamide","(2S,4S)-1-Acetoxy-16-heptadecene-2,4-diol","1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine","Tropate","2,5-Furandimethanol","LPC(O-18:0/0:0)","LPC(16:0/0:0)","Isopropyl dodecylfluorophosphonate","2-(1-methyl-1H-imidazol-5-yl)acetic acid","Lupenone","2,4-Dimethyl-2-pentene","Flunisolide","2H-Benzimidazole-2-thione, 1,3-dihydro-4-methyl-","cis-4-Octenedioic acid","3-Methylcyclohexanethiol","Xanthosine","N-Acetylarylamine","Citric acid","Ethyl p-methoxycinnamate","Vergentan","DL-Propargylglycine","1-Hydroxymidazolam","2-Undecanone","Gyromitrin","Acetylcholine chloride","N'-Hydroxybenzenecarboximidamide","Quinestrol","N-(2-hydroxyethyl)icosanamide","1-nitrosonaphthalene","(2S,3E,6R)-3,7-Dimethyl-3-octene-1,2,6,7-tetrol","Tyr-Phe","Pipecolic acid","Protopanaxadiol","Dazomet","isovaleryl-Val-Val-Sta(3xi,4xi)-Ala-Sta(3xi,4xi)-OH","Methyl cinnamate","2,7-Dihydroxy-5-methyl-1-naphthoic acid","Mirtazapine","S-Sulfo-L-Cysteine","Carnitine C5:0","Stearic acid","Flavin adenine dinucleotide","2-Oxazolidinone","6,10,14-Trimethylpentadecan-2-one","DL-Ornithine","2,5,8,11-Tetraoxatridecan-13-ol","[2,3-Dihydroxypropyl(2-hydroxyethyl)amino]phosphonic acid","1,1-Dichloroethane","Dermorphin","Carnitine","Bisphenol A","Benzofuran","1,2-Dimethylnaphthalene","2-Methyl-1-pyrroline","2-Phenylpropionate","O-acetyl-L-serine","(2R,3R)-3-Methylglutamyl-5-semialdehyde-N6-lysine","Cyclohexanol","PE-NMe(18:1(9Z)/18:1(9Z))","2'-Deoxyadenosine-5'-monophosphate","[2-[(4E,7E,10E,13E,16E,19E)-docosa-4,7,10,13,16,19-hexaenoyl]oxy-3-hexadecoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate","Diphenidol","5-Methoxyindoleacetate","1,5-Anhydrosorbitol","Hexetidine","Diclofenac","Testosterone enanthate","L-Tryptophanamide","N-Acetylcysteine","1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine","3',5'-Cyclic IMP","Fluorouracil","Chloroform","5alpha-Androstane-3alpha,17beta-diol","Thymine","Cytidine 3'-monophosphate","(alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform A (protein)","DL-Leucine","L-3-Aminodihydro-2(3H)-furanone","Mesalazine","Sarcosine","Maltol","2-Hydroxy-4-(methylthio)butyric acid","MG(16:0/0:0/0:0)","Procaterol hydrochloride hemihydrate","N-Palmitoylglycine","Diafenthiuron","Taurine","PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","Amastatin","1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine","Trans-Zeatin","Arachidic acid","3-Buten-1-ol","Methyl benzoate","3-Hydroxy-2,4-dioxopentyl phosphate","N-Methylbenzylamine","2-Hydroxybenzaldehyde","Ser-Asp","Pramipexole","Lithocholic acid","cytidine monophosphate N-acetylneuraminic acid","Met-Trp","Ethenzamide","L-Threonine","2-Aminophenol","Cyclopamine","Benzo[a]pyrene","NADP nicotinamide-adenine-dinucleotide phosphate","(2Z,4Z)-2-hydroxyhexa-2,4-dienoic acid","L-Leucine","Trigonelline","Pyridoxal","LPC(16:1/0:0)","2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine","N-Nonanoylglycine","N-Acetyl-D-glucosamine","Beclamide","Tyramine O-sulfate","Danazol","LPC(20:2/0:0)","2-Phenylethynesulfonamide","Deoxyuridine-5'-diphosphate","3,4-Dimethyl-1,2-cyclopentanedione","Ribonic acid","N6-Succinyl Adenosine","Guanosine-5'-monophosphate","Ubiquinone-2","1-Stearoyl-2-arachidonyl-sn-glycero-3-phosphocholine","Aminoethoxyacetic acid","Pralidoximum","Tetramethylsilane","Imiquimod","Geranylgeraniol","Calcitriol","p-Anisidine","Ethyl alpha-linolenate","S-adenosylmethionine","1-Phenyl-1-propanone","Gossypetin 8-glucuronide 3-sulfate","Quinaldic acid","L-methionine sulfoxide","3,4-Dihydroxystyrene","Sulforaphane","Octopamine","Carnitine C6:1","L-Tryptophan","(2R)-2-[(2R,3R,4S)-3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-hydroxyethyl dodecanoate","Syringaldehyde","LPC(15:0/0:0)","Glucosamine 1-phosphate","Methoxyphedrine","Dammarenediol-I","2-Amino-1-phenylethanol","Glycocyamine","Dopamine","3-Hydroxylidocaine","gamma-Tocopherol","N-Acetyl-beta-alanine","Pyrazinamide","Cholesterol","4-aminobenzoate","Eicosadienoic acid","Dibutyl sebacate","2,3-Dihydroxypropyl hexanoate","Palmitoyl Serinol","Antimony trioxide","L-Valine","Myosmine","Uracil","N-oleoylglycine","Rhein","11-Dehydrocorticosterone","Vidarabine","Crotonic acid","Cuminaldehyde","8,9-Epoxyeicosatrienoic acid","1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine","Alanylarginine","Sinapic acid","2-Phospho-D-Glyceric Acid","4-Oxo-L-proline","Creatine","DL-Homocysteine","Inosinic acid","Diaveridine","Nandrolone decanoate","4-(2,6,6-Trimethylcyclohexa-1,3-dienyl)but-3-en-2-one","Oxiglutatione","3-Nitroacrylic acid","Cytosine","Risperidone","N-Nitrosomethylethylamine","Ethosuximide","Dihydrorhodamine 123","1-(4-Methoxyphenyl)-4-methylpentan-3-ol","Paliperidone","(4E)-2-Oxohexenoic acid","LPC(0:0/22:5)","Angiotensin I/II (5-8)","Paraxanthine","LPE(0:0/24:0)","Dephospho-CoA","Nicotine","Adrenic acid","5-Aminoimidazole","7alpha,12alpha-Dihydroxycholest-4-en-3-one","p-Coumaroylagmatine","Trimethylolpropane","4-Hydroxy-9-fluorenone","n-Isopropylbenzenesulfonamide","LPC(18:0/0:0)","4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, (2S,3S,5R)-","Cumyluron","2-Methoxybenzaldehyde","1-Cyano-2-hydroxy-3-butene","Acetylpseudotropine","1-Phenylethanol","1-[(4-amino-3-methylphenyl)methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid","Heptenophos","Vaccinoside","Phensuximide","Harmaline","L-Glutamic acid","S-(5-Adenosy)-L-Homocysteine","NADP+","Tetradecanal","17-Octadecynoic acid","Tetraethyl pyrophosphate","Omeprazole","1,6-di-O-phosphono-beta-D-fructofuranose","gamma-Linolenic Acid","LPC(O-18:1)","Uridine-5'-diphospho-N-acetylgalactosamine disodium salt","Norepinephrine","LPE(16:1/0:0)","N-(dodecanoyl)-sphing-4-enine-1-phosphocholine","PC(O-16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","Dimethylglycine","Glutamine","Aminoacetone","(2S,3S,4S,5R,6S)-6-[4-[2-Amino-1-(1-hydroxycyclohexyl)ethyl]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid","3-Methylbenzyl alcohol","Palmitic acid","Bardoxolone","4,5-Dihydrovomifoliol","2-Methylbenzyl alcohol","Bicine","beta-Glycerophosphoric acid","3-p-Coumaroylquinic acid","Vitamin E","Alanyllactate","2,4-Diaminobutyric acid","Carnitine C16:2","Tetranorbiotin","Carnitine C16:0","4-Oxo-4-(pyridin-3-yl)butanal","Leu-Gly-Pro","Vitamin K","1,10-Phenanthroline","1,2,3,4,5-Benzenepentol","2-Hexenoylcholine","Amlexanox","(S)-Methylmalonic acid semialdehyde","Isopetasoside","2-Octene","(2S)-2-amino-3-(3,4-dihydroxypyridin-1-ium-1-yl)propanoic acid","1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate","3-Methylglutaric acid","(E)-2-Butenyl-4-methyl-threonine","Fluoromidine","LPC(0:0/20:3)","Glucovanillin","MG(0:0/18:2(9Z,12Z)/0:0)","LPC(0:0/20:4)","Thiethylperazine","1-[(2-Chloro-1,3-thiazol-5-yl)methyl]-2-methyl-3-nitroguanidine","Deisopropylhydroxyatrazine","N-Acetylputrescine","Scopoloside I","PC(14:0/18:3(9Z,12Z,15Z))","Xanthine","2,3-Dihydroxy-4-methoxybenzoic acid","(3Z,6Z,9Z)-dodecatrienol","7-Ethoxy-4-methylcoumarin","PC(O-16:0/O-2:0)","Choline","PC(8:0/8:0)","Asparagine","3-O-alpha-mycarosylerythronolide B","2,3-Dihydrobenzofuran","Trp-Pro","Nicotinic acid","5-Hydroxymethyluracil","4-Methoxy-2-[3-(4-methoxyphenyl)oxiran-2-yl]-2,3-dihydropyran-6-one","DL-Methionine","L-Isoleucine","2-(((2-Ethylhexyl)oxy)carbonyl)benzoic acid","L-alpha-Aminobutyric acid","trans, trans-3,5-Octadien-2-one","(2-(1-Butoxyethoxy)ethyl)benzene","4-Amino-3-hydroxybutyrate","Novaluron","9alpha,11alpha,15R-Trihydroxy-17-phenyl-18,19,20-trinor-prost-5Z-en-1-oic acid, isopropyl ester","Mercaptopurine","Isobutyrylglycine","7-Methylxanthine","o-Tyrosine","N-Oleoyl-4-aminobutyric acid","Glufosinate","Eupatorin","Asn-Tyr","Palmitoylcarnitine","Cefoxitin","Swertiamarin","Glycyl-L-leucine","Colladonin","APGPR Enterostatin","Solasodine","Pyrrole","Diosgenin","L-Aspartic acid","Isonicotinamide","Tetradecylamine","4'-Methylacetophenone","Sarsasapogenin","Isolithocholic acid","Methyl oleate","LPI(18:1)","delta-Tocopherol","N-Cyclohexylformamide","4-Hydroxyphenylpyruvic acid","6-Methyl mercaptopurine","Dodecyl glucopyranoside","Epsilon-caprolactam","(2S,3S)-2-amino-3-phenylbutanoic acid","Piperidine","5alpha-Cholestan-3-one","Metaxalone","Tilarginine","Spermidic acid","Cimetidine","Aminopentol","Lithospermoside","Phosphocholine","Trp-Asp","1-o-Hexadecyl-2-oleoyl-sn-glycero-3-phosphocholine","Xylitol","acetoacetate","1-Heptadecanoyl-sn-glycero-3-phosphocholine","Alfentanil","1-Hydroxypyrene","Norbuprenorphine","Glycyl-L-phenylalanine","Isoeugenyl acetate","Methylmalonic Acid","Vanillin","Cer(d18:0/12:0)","5-(1,1-Dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]phenol","Propiomazine","Enantio-PAF C-16","Lumazine","Mechlorethamine","N,N-dihydroxy-L-isoleucine","1,2-Distearoyl-sn-glycero-3-phosphocholine","Riboflavin","2-Aminoacetaldehyde","2-Oxo-3-(5-oxofuran-2-ylidene)propanoic acid","Stearoylcarnitine","Glu-Leu","N-Nitrosodipropylamine","BW-A868C","1,2-Dipentadecanoyl-sn-glycero-3-phosphocholine","2-Methylbenzoic acid","4-Hydroxy-5-(3,4,5-trihydroxyphenyl)pentanoic acid","2-Methyl-1-methylthio-2-butene","Reboxetine","Nevadensin","Leu-Tyr","Ternatin heptapeptide","1-O-Hexadecyl-2-arachidonoyl-sn-glycero-3-phosphocholine","Nicotinic acid adenine dinucleotide","Fucoxanthin","2-Acetyl-3-methylpyrazine","Arecoline","L-Proline","(+/-)-Eriodictyol","N-succinyl-L,L-2,6-diaminopimelate","Phenol","L-dihydroanticapsin","Uridine-5'-monophosphate","1-beta-D-Galactosylsphingosine","Ampicillin","Aminosalicylic Acid","CerP(d18:1/12:0)","3-Hydroxyanthranilic acid","[2-hydroxy-3-[(9Z,12Z)-octadeca-9,12-dienoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate","Dicyclohexylamine","cis-4-Hydroxy-D-proline","3-Ethylphenol","4-Ethylphenol","l-Alanyl-l-leucine","Stearoylethanolamide","Dicyclomine","L-lysinium(1+)","4-Propylphenol","Demeton-S-methyl","1-(D-3-Mercapto-2-methyl-1-oxopropyl)-L-proline","DL-Serine","Melamine","Fluoxetine","Miglitol","N-Acetylcadaverine","Ifenprodil","Dihydrocapsaicin","Betulinic acid","Triethylenetetramine","LPE(18:1/0:0)","Ciprofloxacin","4-Pyridoxic acid","Vitamin D3","3-Hydroxymugineic acid","Isovaleric acid","Guanosine","N-Acetyl-L-methionine","N,N-Dimethylaniline N-oxide","Fluvoxamine Acid","(¡À)-2-Propylthiazolidine","4-Methoxycinnamic acid","4-(5-Hydroxy-2-methyl-2-azabicyclo[2.2.2]octan-5-yl)-3-methylbutanoic acid","Tetradecanoylcarnitine","Hypotaurocyamine","Euscaphic acid","25-Hydroxycholesterol","Cerbertin","1-O-Palmitoyl-2-O-acetyl-sn-glycero-3-phosphorylcholine","Lactaldehyde","Cucurbitin","Dimethylallyl phosphate","(S)-Remoxipride","2'-Adenylic acid","Oxalacetic acid","Dichlorvos","2alpha,3beta,12alpha,21,24(R),25-Hexahydroxylanost-8-ene","D-Mannosamine","Raloxifene","L-Homocysteic acid","Eicosanedioic acid","N-(Carboxyaminomethyl)urea","11-nitro-1-undecene","Makisterone A","Indole-3-carbinol","Angiotensin IV","Phenethylamine","Isoxanthopterin","Triacetin","N-[2-[[[[(2S,3R)-2-(Hexadecanoylamino)-3-hydroxy-4-octadecenyl]oxy]hydroxyphosphinyl]oxy]ethyl]trimethylaminium","2-Amino-1,6-dimethylfuro[3,2-e]imidazo[4,5-b]pyridine","Lauroyl diethanolamide","2,4-Dihydroxyacetophenone 5-sulfate","(1R,2R,9R)-1-piperidin-2-yl-3,15-diazatetracyclo[7.7.1.02,7.010,15]heptadecane","Obacunone","Diethanolamine","Cerulenin","Isoniazid","1,4-Dimethylphenanthrene","Methyl 3-[[2-[4-(1-adamantyl)phenoxy]acetyl]amino]-4-hydroxybenzoate","Glutathione Reducedform","1-Palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine","Tomatidine","Aromadendrin","Aklomide","MG(18:2/0:0/0:0)","5,5-Dimethyl-1-pyrroline N-oxide","L-Tyrosine","1-Methylpyrrolidine-2-carboxylic acid","Malaoxon","Hypotaurine","4-Chlorobenzenesulfonimidic acid","1-Isothiocyanatohexane","Auraptene","Phenylalanylphenylalanine","Dehydronuciferine","1-Deoxynojirimycin","Naftidrofuryl","[3-[2-(dimethylamino)ethoxy-hydroxyphosphoryl]oxy-2-hexadecanoyloxypropyl] (Z)-octadec-9-enoate","3-Aminopropionaldehyde","Spermidine","Triethylamine","1-Stearoyl-2-Arachidonoyl PC-d8","Isofraxidin","Methyl 2,5-dihydroxycinnamate","Menadiol diphosphate","S-Phenyl-N-acetylcysteine","1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine","1-Octadecanoyl-cyclophosphatidic acid","3,8'-Biflaviolin","3-Aminobutyrate","Lopinavir","Mecillinam","LPE(18:0/0:0)","N,N-dimethylarginine","Thiotepa","Naphthyl dipeptide","1-O-Hexadecyl-2-acetyl-sn-glycerol","D-Allothreonine","Methyl aminolevulinate","1,2-di-[(11Z)-eicosenoyl]-sn-glycero-3-phosphocholine","3-(4-methoxyphenyl)oxirane-2-carboxylic Acid","Fluoranthene","beta-N-Methylamino-L-alanine","N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphocholine","3-Mercapto-2-butanone","Zearalenone","Isovaleraldehyde","Lysergamide","3-Pyridinemethanol","Tetraethylene glycol","Ethyl maltol","3-Methoxyanthranilate","[2-[(9Z,12Z)-octadeca-9,12-dienoyl]oxy-3-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate","Astemizole","Leucyl-leucyl-tyrosine","3-Methylcyclopentene","Octadecanamide","Amoxapine","Acetophenone","Alprenolol","2-Hydroxypyridine","6-Hydroxybuspirone","Creatinine","1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine","Tyr-Lys","11-Oxahexadecanolide","1-Docosanoyl-sn-glycero-3-phosphocholine","Acetyl-L-carnitine","Diuron","Pyridoxine","Methyl hexadecanoic acid","Gibberellin A79","1-O-Hexadecyl-sn-glycero-3-phosphocholine","Carbazole","Dibasic sodium phosphate","Octahydro-2,5,5,8a-tetramethyl-7H-1-benzopyran-7-one","Fludarabine phosphate","2-Phenylacetamide","2-Hydroxyimipramine","2-Amino-4-oxopentanoate","Ethyl benzoate","Oglufanide","Propyzamide","Fosfosal","Hexaethylene glycol","4-Hydroxystyrene","N-ethylmaleimide","Apocarotenal","protoporphyrin IX","Palmitic amide","LPE(0:0/24:1(15Z))","Prednisolone tebutate","2-(1-methyl-1H-imidazol-4-yl)acetic acid","(r)-Methylmalonate semialdehyde","Cinobufagin","10,11-Dihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid","5-Fluorouridine","Betaine","Dihomo-gamma-linolenoylethanolamide","Luminol","L-Alanine","Nimesulide","Glu-Tyr","5-Dimethylamiloride","1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine","3-Formylsalicylic acid","Pterin","1-Aminocyclopropane-1-carboxylic acid","behenate","PC(18:0/18:2)","Enrofloxacin","Cytidine","1-Hexacosene","N-Acetyl-L-aspartic acid","4-(Aminomethyl)benzoic acid","Uridine-diphosphate-n-acetylgalactosamine","Pyridostigmine","L-Lysine","Digitoxigenin 3-[glucosyl-(1->6)-glucosyl-(1->4)-2,6-dideoxyribohexoside]","5-Fluoro-2-methoxypyridin-4-amine","Letrozole","Azelaoyl PAF","(2S,4S)-2-amino-5-(carbamoylamino)-4-hydroxypentanoic acid","2-Palmitoyl-rac-glycerol","Dodecanoic acid","Misoprostol","Genipin","Phytolaccasaponin B","Octylamine","Phenethyl rutinoside","6-Methyltetrahydropterin","Sphinganine","7-Nitroindazole","N-Methylalanine","2-Phenylpropanal","2-Iminobutanoic acid","N-Acetyl-DL-phenylalanine beta-naphthyl ester","Metoprolol","N-octanoylsphingosine 1-phosphate","D-Glucose 6-Phosphate","N-Palmitoylsphingomyelin","4-Hydroxyphenylglyoxylic acid","Nootkatone","4-Methylbenzyl alcohol","Hydroxyzine","25-Hydroxyvitamin D2","Naftopidil dihydrochloride","Oxybutynin","2-Cyanopyridine","Ethisterone","Isonicotinic acid","Gallopamil","Allantoin","Angiotensin III","4-Chloroaniline","5-Methoxy-L-Tryptophan","Cinnarizine","L-Homoserine","(E,9E)-9-(chloromethylidene)-N-[(E)-3-methoxy-5-[(2S)-2-methyl-5-oxo-2H-pyrrol-1-yl]-5-oxopent-3-enyl]-6-methyltetradec-4-en-13-ynamide","1,11-Undecanedicarboxylic acid","p-Synephrine","Glyc-Pro","N-(2-Hydroxyethyl)hexadec-9-enamide","Kynurenic acid","Buprenorphine Glucuronide","Rhynchophylline","LPC(O-16:0/2:0)","(Z)-1-(Methylthio)-5-phenyl-1-penten-3-yne","1-Aminocyclohexanecarboxylic acid","2,8-Quinolinediol","Prolyl-cysteine","Phytol","Esmolol","Ciclopirox","Methionine","Barbituric acid","Styrene Oxide","p-Coumaryl alcohol 4-O-glucoside","Deisopropylatrazine","Benzamidine","Mephentermine","3-O-alpha-L-Arabinopyranosyl-L-arabinose","Styrene","Ethyl hexadecanoate","Glycerophospho-N-Palmitoyl Ethanolamine","Dopaquinone","2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one","2,6-Dichloro-1,4-phenylenediamine","3-Sulfopyruvic acid","Celastrol","5-alpha-Dihydrotestosterone glucuronide","4-Hydroxyhexan-3-one","Geranyllinalool","Deferoxamine","Benzenemethanamine, N-butyl-4-chloro-","2-oxo-3-phenylpropanoate","[2-hexadecanoyloxy-3-[hydroxy-[2-(methylamino)ethoxy]phosphoryl]oxypropyl] (Z)-octadec-9-enoate","3-(4-Hydroxyphenyl)chroman-7-ol","1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine","L-Norleucine","4-Hydroxy-3-nitrosobenzamide","N-Ethylacetamide","Pentadecanoic acid","S-Formylglutathione","5,6-Dimethylbenzimidazole","1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine","2-Hydroxy-cis-hex-2,4-dienoate","Tentoxin","Niacinamide","Trans-3-hydroxy-L-proline","Xylobiose","1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine","Nitrofurantoin","Serotonin","(2R,4S)-2,4-diaminopentanoic acid","2-Arachidonoyl glycerol-d5","Laurylsulfate","Melizame","2(5H)-Furanone","5-Hydroxymethyl-2-furancarboxaldehyde","Heptethylene glycol","Flurandrenolide","Hexylamine","Tiopronin","Pipericine","L-prolinamide","Carnitine C9:0","N-Acetylserotonin","1-hexadecanoyl-2-[(Z)-octadec-9-enoyl]-sn-glycerol 3-(2-trimethylaminoethylphosphonate)","o-Xylene","2,3-Diaminopropionic acid","Acetyleugenol","Phytosphingosine","N-(Hydroxymethyl)acrylamide","2-Acetylpyrazine","Etiocholanolone glucuronide","Prolyltryptophan","Isopentenyl pyrophosphate","psi-Pelletierine","1-Oleoyl-2-acetyl-sn-glycerol","Arachidonoyl Serinol","5-keto-D-gluconic acid","Ergocalciferol","Fumitremorgin C","(2R)-2-Hydroxy-2-methylbutanenitrile","alpha-Hydroxyisobutyric acid","5'-Deoxy-5'-(Methylthio) Adenosine","Coumarin","2,3-Bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine","7,8-diaminopelargonate","Spermine","Myristic acid","2-Phenylethanol","Hypoxanthine","Temozolomide","Crotonic acid betaine","Dihydro-5-propyl-2(3H)-furanone","Hippuric acid","2-Arachidonoylglycerol","N8-Acetylspermidine","3-Aminopiperidine-2,6-dione","Cytarabine","Methyl stearate","4-Bromophenylacetic acid","Pyridoxal hydrochloride","5-Methyluridine","Glyceryl arachidonate","3-(11,12-Dihydroxy-15,19-dotriacontadienyl)-5-methyl-2(5H)-furanone, 9CI","Etilamfetamine","Ethyl tetradecanoate","D-Serine","Dihydro-2-methoxy-2-methyl-3(2H)-thiophenone","Enoxacin","Adenine","Bis(2-ethylhexyl) phthalate","Dimaprit","Phenols","L-Serine","Inosine","S-Methyl-L-methionine","Purine","L-rhamnulose","Lumichrome","Bufexamac","2-Pyrrolidinone","Dibutyl disulfide","Leu-Ile","3,4-Dimethylbenzoic acid","LPE(16:0/0:0)","Firefly luciferin","Melibiose","Pirimicarb","1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine","Ellagic acid","1,2-Cyclohexanedione","Methyl 3-methyl-2-oxopentanoate","Gentian violet cation","Caffeine","N-hexanoylsphingosine","Myristoylcarnitine","Indoramin","Pyridine-3,4-dicarboxylic acid","Stigmatellin Y","3-Hydroxybenzaldehyde","xI-Dihydro-2-methyl-3(2H)-thiophenone","Cucurbitacin I","3-Methylmethcathinone","Erythronolide B","2-Aminoethyl dihydrogen phosphate","Sebacic acid","Dihydrouracil","cotinine N-oxide","beta-Sitosterol","1,1,6-Trimethyl-1,2-dihydronaphthalene","Cys-Phe","2-Monoolein","Maslinic acid","1-Linoleoyl-3-docosahexaenoyl-sn-glycerol","2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide","2,2,6,6-Tetramethyl-4-piperidinone","Dimethyl phthalate","4-Ethylbenzoic acid","Picolinic acid","Diisobutyl phthalate","2-Phenoxyethanol","(-)-Anabasine","Ethyl carbamate","Pyroglutamic acid","Danthron","Cyclocreatine","Ecdysone","Perphenazine","8,9-DiHETrE","Stigmasta-4,22-dien-3-one","Isopalmitic acid","Shikimic Acid","Coriolic acid","Palmitoleoyl Ethanolamide","2-Oxoarginine","Nonaprenyl-4-hydroxybenzoate","6-Aminonicotinamide","Androsterone","Phosphatidylinositol 4-phosphate","Phenyl beta-D-glucopyranoside","4-Azaniumyl-4,5-dihydro-1,2-oxazol-3-olate","1-arachidonoyl-sn-glycero-3-phospho-1D-myo-inositol","N-Acetyl-L-alanine","Acetylcholine","Ethyl methanesulfonate","alpha-Ribazole-5'-phosphate","9-nitro-9E-octadecenoic acid","Dibutyl phthalate","1-Palmitoyl-2-myristoyl-sn-glycero-3-phosphocholine","Glucurolactone","FFA(18:4)","3-Palmitoyl-sn-glycerol","Spinorphin","Pantetheine","1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)","L-Dihydroorotic acid","Valerosidate","D-Homocysteine","N,N-dimethylsphingosine","Azaperone","LPC(22:6/0:0)","Pentostam (TN)","PE(22:4(7Z,10Z,13Z,16Z)/P-18:1(11Z))","Benzaldehyde","20-Hydroxyecdysone","Prolyl-Histidine","1-Oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine","Miltefosine","Histamine","Methylamine","N-Acetylneuraminic Acid(SA)","Clopidol","Pyruvic Acid","Poloxamer-188","N-Methyl-D-aspartic acid","VERBENONE","LPC(14:0/0:0)","Methionine sulfoxide","Guanosine-5'-diphosphate","Allantoic acid","1,3-Dicyclohexylurea","1,3,6,8-Tetrahydroxynaphthalene","O-Acetyl-L-homoserine","PC(O-16:0/O-1:0)","2-Amino-2-methyl-1,3-propanediol","Phosphonoacetaldehyde","Pyrrolidine","MG(18:0/0:0/0:0)","Epinephrine","4-Chloro-L-phenylalanine","8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)tetracenomycin C","Bergapten","Imidazoleacetic acid","Carnitine-2-methyl-C4","Clozapine","FFA(18:3)","1-pentadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine","Psoralen","3b-Hydroxy-5-cholenoic acid","Isatin","Norvaline","Biopterin","Leu-Gly","cis-7-Hexadecenoic Acid methyl ester"],"additional_accession":[]},"is_claimable":false,"name":"Uridine Attenuates Osteoclastogenesis and Ovariectomy Induced Bone Loss by Modulating the PI3K/Akt–FoxO ROS Signaling Axis","description":"Osteoporosis is a metabolic bone disorder characterized by aberrant osteoclast activation, leading
to excessive bone resorption and microarchitectural deterioration. Although the interconnection
between osteoclast differentiation and cellular energy metabolism has been increasingly appreciated,
the contribution of pyrimidine metabolism to this process remains largely undefined. Here,
integrative transcriptomic and metabolomic profiling delineated a distinct metabolic remodeling
during osteoclastogenesis and identified uridine as a pivotal metabolite exhibiting a pronounced
decline upon RANKL stimulation. Functional and mechanistic studies demonstrated that exogenous
uridine supplementation effectively restrained osteoclast formation and bone resorptive activity,
concomitant with the downregulation of NFATc1 and CTSK expression. In OVX mice, uridine
administration ameliorated trabecular microarchitecture, reduced osteoclast burden, and mitigated
bone loss. Mechanistically, uridine inhibited PI3K/Akt phosphorylation, facilitated FoxO nuclear
translocation, and suppressed ROS accumulation, thereby preventing NFATc1 activation and
nuclear import. Collectively, this study uncovers a previously uncharacterized metabolic–signaling
coupling mechanism linking pyrimidine metabolism to osteoclastogenesis and establishes uridine
as a potential metabolic modulator for the prevention and treatment of osteoporosis.
","dates":{"publication":"2026-04-09","submission":"2025-11-27"},"accession":"MTBLS13394","cross_references":{"HMDB":["HMDB0000288","HMDB0000045","HMDB0000251","HMDB0000217","HMDB0000195","HMDB0000296","HMDB0001397","HMDB0000175","HMDB0000673","HMDB0000095","HMDB0003229","HMDB0000289","HMDB0003426","HMDB0000148","HMDB0000159","HMDB0000300","HMDB0013622","HMDB0000207","HMDB0000182","HMDB0000806","HMDB0000929","HMDB0011130","HMDB0000158","HMDB0001901","HMDB0006331","HMDB0000784","HMDB0061706","HMDB0000939","HMDB0062203","HMDB0000619","HMDB0000893","HMDB0000935","HMDB0001227","HMDB0000786","HMDB0002649","HMDB0000292","HMDB0001173","HMDB0034297","HMDB0029082","HMDB0000765","HMDB0000125","HMDB0000157","HMDB0000177","HMDB0000299","HMDB0002000","HMDB0000243","HMDB0002092","HMDB0000187","HMDB0002059","HMDB0002212","HMDB0000247","HMDB0000755","HMDB0000634","HMDB0000008","HMDB0031557","HMDB0010217","HMDB0003391","HMDB0002752","HMDB0000167","HMDB0005998","HMDB0015371","HMDB0004385","HMDB0000696","HMDB0036136","HMDB0011753","HMDB0000254","HMDB0002031","HMDB0000273","HMDB0001085","HMDB0000176","HMDB0000912","HMDB0000698","HMDB0003033","HMDB0000872","HMDB0000230","HMDB0028995","HMDB0002107","HMDB0013247","HMDB0000883","HMDB0002710","HMDB0000050","HMDB0000244","HMDB0000766","HMDB0001844","HMDB0013716","HMDB0001341","HMDB0000720","HMDB0041929","HMDB0000215","HMDB0002311","HMDB0000788","HMDB0062590","HMDB0029007","HMDB0001645","HMDB0003355","HMDB0000267","HMDB0003681","HMDB0000767","HMDB0003640","HMDB0011134","HMDB0010382","HMDB0001176","HMDB0002261","HMDB0001248","HMDB0002536","HMDB0031219","HMDB0250755","HMDB0000138","HMDB0000107","HMDB0000005","HMDB0006111","HMDB0029713","HMDB0000202","HMDB0001987","HMDB0000568","HMDB0010384","HMDB0000012","HMDB0000030","HMDB0000011","HMDB0011506","HMDB0011566","HMDB0000209","HMDB0041627","HMDB0000073","HMDB0001879","HMDB0013899","HMDB0000225","HMDB0000538","HMDB0001366","HMDB0000226","HMDB0000626","HMDB0032562","HMDB0034146","HMDB0000484","HMDB0000719","HMDB0000098","HMDB0062538","HMDB0000439","HMDB0029098","HMDB0001245","HMDB0000094","HMDB0000034","HMDB0002122","HMDB0002385","HMDB0002432","HMDB0013163","HMDB0031058","HMDB0003034","HMDB0001347","HMDB0247578","HMDB0000695","HMDB0003540","HMDB0002068","HMDB0003871","HMDB0002928","HMDB0000953","HMDB0002917","HMDB0011632","HMDB0001889","HMDB0001178","HMDB0003466","HMDB0000840","HMDB0000099","HMDB0003701","HMDB0000349","HMDB0001939","HMDB0001991","HMDB0001043","HMDB0003134","HMDB0004708","HMDB0002349","HMDB0000043","HMDB0002985","HMDB0029457","HMDB0004089","HMDB0000518","HMDB0002899","HMDB0001900","HMDB0011621","HMDB0000063","HMDB0003011","HMDB0001857","HMDB0000957","HMDB0000139","HMDB0000208","HMDB0000189","HMDB0010738","HMDB0002343","HMDB0000295","HMDB0000700","HMDB0001865","HMDB0028795","HMDB0011600","HMDB0001546","HMDB0015167","HMDB0000328","HMDB0002128","HMDB0013680","HMDB0001527","HMDB0042032","HMDB0000365","HMDB0000019","HMDB0003903","HMDB0245953","HMDB0001367","HMDB0000955","HMDB0032012","HMDB0004136","HMDB0000259","HMDB0002199","HMDB0003080","HMDB0040733","HMDB0000956","HMDB0000576","HMDB0004029","HMDB0000905","HMDB0000805","HMDB0000687","HMDB0144295","HMDB0002815","HMDB0000826","HMDB0006528","HMDB0006294","HMDB0002177","HMDB0002234","HMDB0031057","HMDB0002231","HMDB0010379","HMDB0000172","HMDB0002097","HMDB0002226","HMDB0010378","HMDB0000387","HMDB0112194","HMDB0005060","HMDB0000210","HMDB0002368","HMDB0002925","HMDB0002340","HMDB0000156","HMDB0008928","HMDB0240594","HMDB0001051","HMDB0030016","HMDB0002823","HMDB0037209","HMDB0034153","HMDB0060180","HMDB0000968","HMDB0014602","HMDB0003312","HMDB0004670","HMDB0138216","HMDB0061656","HMDB0001259","HMDB0061859","HMDB0001999","HMDB0011517","HMDB0240219","HMDB0000868","HMDB0014581","HMDB0038361","HMDB0031463","HMDB0000286","HMDB0005088","HMDB0010219","HMDB0014917","HMDB0001209","HMDB0001439","HMDB0001280","HMDB0007856","HMDB0010630","HMDB0012233","HMDB0013211","HMDB0000549","HMDB0007865","HMDB0000653","HMDB0041912","HMDB0010169","HMDB0029683","HMDB0029811","HMDB0000290","HMDB0038704","HMDB0001127","HMDB0000042","HMDB0002022","HMDB0011111","HMDB0062251","HMDB0142137","HMDB0000773","HMDB0037790","HMDB0002520","HMDB0011394","HMDB0001044","HMDB0033615","HMDB0038406","HMDB0028831","HMDB0014997","HMDB0012157","HMDB0001368","HMDB0031066","HMDB0126552","HMDB0000318","HMDB0038165","HMDB0009003","HMDB0003381","HMDB0034070","HMDB0000119","HMDB0005783","HMDB0002818","HMDB0001555","HMDB0015274","HMDB0038419","HMDB0030008","HMDB0008923","HMDB0032923","HMDB0032797","HMDB0033897","HMDB0001864","HMDB0000252","HMDB0002141","HMDB0030830","HMDB0039531","HMDB0014841","HMDB0001981","HMDB0001383","HMDB0014961","HMDB0033067","HMDB0059925","HMDB0002117","HMDB0001004","HMDB0000674","HMDB0000308","HMDB0013657","HMDB0035196","HMDB0007982","HMDB0002994","HMDB0014404","HMDB0008937","HMDB0039093","HMDB0000250","HMDB0008038","HMDB0002655","HMDB0014938","HMDB0028832","HMDB0004486","HMDB0015118","HMDB0030956","HMDB00079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