MetaboLights

application/xml

ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13708/m_MTBLS13708_LC-MS___metabolite_profiling-1_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13708/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13708/a_MTBLS13708_LC-MS___metabolite_profiling-1.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13708/a_MTBLS13708_LC-MS_alternating_hilic_metabolite_profiling.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13708/s_MTBLS13708.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13708Mass accuracy was controlled within 10 ppm, and metabolites were identified by combining MS and MS/MS information. Data were normalized and subjected to quality control. Variables with relative standard deviation (RSD) > 30% were removed, and the remaining data were log-transformed to correct for heteroscedasticity.MetaboLightsPublicLiquid Chromatography MS -Liquid Chromatography MS - alternating - hilicMetabolites were profiled using an ultra-high-performance liquid chromatography coupled with Triple Time-of-Flight mass spectrometry (UHPLC-Triple TOF) system. Chromatographic separation was performed on an ACQUITY UPLC HSS T3 column with mobile phase A (95% water + 5% acetonitrile, 0.1% formic acid) and mobile phase B (47.5% acetonitrile + 47.5% isopropanol + 5% water, 0.1% formic acid) at a flow rate of 0.40 mL/min. The injection volume was 10 μL, and the column temperature was 45 °C. Response Mechanisms of Hepatopancreatic Metabolism and Gut Microbiota in Chinese Mitten Crab (Eriocheir sinensis) Under Chronic High-pH Stress.Shanghai ocean universityyufei liuhepatopancreasmass spectrometry assayApproximately 30 ± 5 mg of hepatopancreas tissue was weighed and processed with grinding beads and an extraction solvent for 6 minutes under cryogenic conditions. The samples were then subjected to low-temperature ultrasonication at 5 °C and 40 kHz for 30 minutes, incubated at –20 °C for 30 minutes, and centrifuged at 13,000 g at 4 °C for 15 minutes. The supernatant was collected for analysis.Eriocheir sinensishttps://www.ebi.ac.uk/metabolights/MTBLS13708zonglin Yang. No. 999, Huicheng Ring Road, Pudong New Area, Shanghai, 201306, China, Shanghai Ocean University. 2105956264@qq.com.yufei liu. Shanghai Ocean University. 1749888121@qq.com.Raw data were imported into Progenesis QI v3.0 software and matched against standard and in-house databases. Ph1749888121@qq.comSamples were collected at 15 days post-challenge (15 dpc) and 30 days post-challenge (30 dpc) of pH stress treatment. The treatment groups were abbreviated as follows: tne pH=8 group at 15 dpc (A8), pH=9 group at 15 dpc (A9), pH=10 group at 15 dpc (A10); pH=8 group at 30 dpc (B8), pH=9 group at 30 dpc (B9), and pH=10 group at 30 dpc (B10). During sampling, juvenile crabs were randomly selected from each replicate of the pH gradient treatment groups. After anesthesia on ice, the crabs were dissected, and their hepatopancreas and intestinal tissues were collected into 2 mL cryopreservation tubes, which were immediately placed in liquid nitrogen. Specifically, tissues from 4 individuals per group were used for transcriptomic analysis, 6 individuals for metabolomic analysis, and 4 individuals for intestinal microbiota analysis. All samples were analyzed as independent biological replicates without pooling. Different individuals were used for each assay due to platform requirements, but all originated from the same experimental batch under identical conditions.Tissues from the remaining individuals were quickly frozen in liquid nitrogen and then transferred to a -80℃ refrigerator for long-term storage.Metabolomicsultra-performance liquid chromatography-mass spectrometryEriocheir sinensisHepatopancreasuntargeted metabolitesultra-performance liquid chromatography-mass spectrometryEriocheir sinensisHepatopancreasuntargeted metabolitesMass spectrometry was conducted with an electrospray ionization (ESI) source in both positive and negative ion modes.MethohexitalLysoPC(20:3(8Z,11Z,14Z)/0:0)Devd--choPC(18:3(9Z,12Z,15Z)/18:0)Lactose--lysinePalustrineSalmeterolAlpha--Linolenoyl ethanolamideAllithiamineepsilon--(Carboxymethyl)lysine;N6--CarboxymethyllysineDiosbulbinoside DE--10--HydroxynortriptylineAspartame2--Hydroxy--6--pentadecylbenzoic acidPGP(20:4(7E,9E,11Z,13E)--3OH(5S,6R,15S)/20:2(11Z,14Z))HistidylvalineEctoineL--Threo--3--PhenylserineIsolappaol C5--(Galactosylhydroxy)--L--LysineAndrostenediol dipropionateArabinofuranosylcytosine;CytarabineChandaloneAvocadyne 1--acetate14--OH ClarithromycinVulgaxanthin I4--cholesten--7|alpha|,12|alpha|,24--triol--3--oneTelocinobufagin4--Amino--1--[(2R,5R)--3,4--dihydroxy--5--(hydroxymethyl)oxolan--2--yl]--5--methylpyrimidin--2--one6--HydroxymelatoninVal--Phe--Val--TyrPC(20:4(5Z,8Z,11Z,14Z)--OH(20)/2:0)Parasorbic acidOvalicin;3,4--Dihydroxy--2--methoxy--4--methyl--3--[2--methyl--3--(3--methyl--but--2--enyl)--oxiranyl]--cyclohexanoneNipecotic acidBiotinEvogliptinSerylisoleucine4--Amino--1--[(1S,2S,4S)--4,5--bis(hydroxymethyl)--2--bicyclo[3.1.0]hexanyl]pyrimidin--2--one(E)--3--(4--Chlorophenyl)--N--(4--methoxyphenyl)prop--2--enamide3--(5,6,6--Trimethylbicyclo[2.2.1]hept--1--yl)cyclohexanolBenzo[a]pyrene--7,8--dihydrodiol--9,10--oxide(2R,3S,5R)--5--(4,5--Dihydroimidazo[2,1--f]purin--3--yl)--2--(hydroxymethyl)oxolan--3--olCysteineglutathione disulfideEthotoinCreatinine lactate12--Hydroxyjasmonic acid glucosideTryptophylhydroxyproline4--hydroxy--2--nonenal--[L--Cys] conjugate11--peroxy--5Z,8Z,12E,14Z--eicosatetraenoateValylserinePS(18:4(6Z,9Z,12Z,15Z)/24:1(15Z))Dioncophylline ABenzenebutanoic acid, alpha--(acetylamino)--2--amino--gamma--oxo--Dimethylmatairesinol2--HydroxyestriolProstaglandin E2Gingerglycolipid A13''--Carboxy--gamma--tocotrienolH--Arg(NO2)--ObzlSoyasaponin bgLeu--Arg--Asn--ArgSulindac;2--[6--Fluoro--2--methyl--3--[(4--methylsulfinylphenyl)methylidene]--1--indenyl]acetic acidAgnusideFiribastatHistidyltryptophanLeucyl--TyrosineGuanosine monophosphateZapoterinSclareol[12]--GingerdiolDeoxypyridinolineValganciclovir, (S)--Endomorphin--12--Hydroxy--L--methionineGlutamylisoleucineGlutaminylprolineGlycyl--PhenylalanineBisnoryangoninalpha--Terpineol acetateMoupinamideMiglitolgamma--GlutamylleucineO--AdipoylcarnitineAstringinPseudouridineFexofenadineLysoPC(14:0/0:0)1--O--Isopentyl--3--O--octadec--2--enoyl glycerolTyrosyl--GlutamateIsolupalbigeninLysoPE(0:0/18:2(9Z,12Z))5--(3''--Hydroxyphenyl)--γ--valerolactone 3''--glucuronideFluocortolone PivalateL--TyrosineDelphinidin 3--(6''''--malonyl--glucoside)2--Phenyl--1,3,5--triazine6--FluoromevalonateL--Valine6--Sulfanyl--1H--pyrimidine--2,4--dioneDehydrosoyasaponin IN--Acetyl--L--glutamate 5--semialdehydeGuanosineTaxine BAtractylenolide IAcolongifloriside K;Ouabain;GlycosidesPE(22:2(13Z,16Z)/P--18:1(11Z))cis--Melilotoside20--Hydroxyeicosatetraenoic acid2,4--Diaminobutyric acid;L--2,4--diaminobutyric acidPhenobarbital N--glucosideAraloside AOctanalIle--Val--ValMG(20:5(5Z,8Z,11Z,14Z,17Z)/0:0/0:0)arabidiolMorinidazole15--Deacetylneosolaniol7,4''--Dihydroxy--8--methylflavanH--Gly--Arg--Gly--Asp--D--Ser--Pro--OHTebuconazole2--HydroxyethanesulfonateGlycylhydroxyprolineGentamicin CEriojaposide APorsonGentamicin By--MorphineMethionyl--ThreonineCabastineLycoperdic acid2--Hydroxycinnamic acid;Coumarinic acidSalmefamolFenvalerateGlutaminylhydroxyproline1--[(2R,3R,4S,5R)--3,4--Dihydroxy--5--(hydroxymethyl)oxolan--2--yl]oxypyrimidin--2--oneSerylmethioninePlastoquinone 9;PlastoquinoneUridine(5Z)--7--[(1R,2R,5S)--5--Hydroxy--2--[(1E,3S,5Z)--3--hydroxyocta--1,5--dien--1--yl]--3--oxocyclopentyl]hept--5--enoylcarnitineLysoPC(20:3(5Z,8Z,11Z)/0:0)Imazamox2--[(1s,2s)--2--Carboxycyclopropyl]--3--(9h--Xanthen--9--Yl)--D--AlanineTramadol;UltramProlyl--MethionineL--Glutamine;D--Glutamine(3Z,6Z)--3,6--NonadienalGalactose 1--phosphateFurathiocarbLysoPA(20:3(5Z,8Z,11Z)/0:0)HistidylserineAlmecillinLeucyl--leucine;Leucylleucine(S,E)--ZearalenoneProstaglandin A1Tryptophyl--LeucineDeoxycytidine;Cytosine deoxyribonucleosideMuzanzagenin(1S,2S,4R)--p--Menth--8--ene--1,2,10--triol 2--glucosidePyridinolineLeukotriene C4;11--trans--Leukotriene C4DG(LTE4/0:0/2:0)gamma--Glutamylvaline1--[(5--Amino--5--carboxypentyl)amino]--1--deoxyfructoseDermatan sulfate;dermatan L--iduronate[3--(2--Aminopropyl)--6--methylidenecyclohexa--1,3--dien--1--yl]methanediolLysoPE(0:0/22:4(7Z,10Z,13Z,16Z))IsobutylidenePS(22:5(4Z,7Z,10Z,13Z,16Z)/20:0)19,20--DiHDPAPI(22:4(10Z,13Z,16Z,19Z)/TXB2)Glucose--6--glutamatePI(22:2(13Z,16Z)/22:6(4Z,8Z,10Z,13Z,16Z,19Z)--OH(7))PyrazoloacridineAleglitazarSaxitoxinLysoPC(15:0/0:0);CE(22:5(7Z,10Z,13Z,16Z,19Z))1--(Hydroxymethyl)--5,5--dimethyl--2,4--imidazolidinedione9--F1--phytoprostaneArgininosuccinic acid[D--Met2, Pro5]--enkephalinamideGlycylprolylhydroxyproline4--Hydroxy--5--[3--(sulfooxy)phenyl]pentanoylcarnitineOrnithine;D--OrnithineN--Arachidonoyl PhenylalanineGly--pro--arg--pro10--EdAMCandesartanPhenylalanylphenylalanineStearidonic acidBrivanib alaninateSkepinone--LSagopiloneArginylhistidine5--Hexyltetrahydro--2--oxo--3--furancarboxylic acidMannobioseTrazodoneEpostaneDocosahexaenoic acidAromadendrin 3--rhamnosideL--Aspartic acidN--((Tetrahydro--5--oxo--2--furanyl)carbonyl)--L--histidyl--L--prolinamideMerodesmosineProstaleneCurcumenoneDibekacinRishitin;Risbitinœâ--hydroxylaurate;12--Hydroxydodecanoic acidGlycyl--LysineDG(20:0/i--19:0/0:0)Taurocholic acidVal--pro--proLysoPE(0:0/20:2(11Z,14Z))Avocadene 1--acetateLysoPC(18:1(11Z)/0:0)3,4,5--trihydroxy--6--{2--hydroxy--5--[(5--oxooxolan--2--yl)methyl]phenoxy}oxane--2--carboxylic acidgamma--Glutamyl--S--methylcysteine sulfoxideHistidylleucine;Histidinyl--LeucineSesamose4--Fluorobenzoic acidZingiberolUreidoisobutyric acidPalmitoylcarnitine;O--PalmitoylcarnitineLysoPA(O--18:0/0:0)LibenzaprilPropionylcarnitine(±)--PelletierinePelargonidin 3--(6''''--malonylglucoside)Acetyllycopsamine9(S)--HOTrE2,4--Hexadienyl acetatemyo--InositolImidazoleacetic acid riboside{1--[2--(4--Carbamimidoyl--benzoylamino)--propionyl]--piperidin--4--yloxy}--acetic acid10,11--Dihydro--12R--hydroxy--leukotriene E4Medicagenic acid 3--O--[b--D--glucosyl--(1|right|2)--b--D--glucoside] 28--O--[b--D--xylosyl--(1|right|4)--a--L--rhamnosyl--(1|right|2)--a--L--arabinosyl] esterAntiarrhythmic peptidegamma--L--Glutamyl--L--pipecolic acidcis--Vaccenic acidLysoPC(16:1(9Z)/0:0)Prenyl glucosideVofopitantAstemizoleNivalenolalpha--AMINO--3--HYDROXY--5--METHYL--4--ISOXAZOLEPROPIONIC ACID(--)--Salsoline;(R)--N--Methylsalsolinol1--Piperideine1--Hydroxyisoquinoline(S)--Oleuropeic acid3'',5''--Dideoxythymidine(2S,3S)--N--(2--Methoxy--5--(trifluoromethoxy)benzyl)--2--phenylpiperidin--3--amineAminodextran1--(1--(3--Methoxyphenyl)cyclohexyl)piperidineNaloxazoneFLESTOLOLBursin1,2--Cyclohexanediol, 1--methyl--4--(1--methylethenyl)--Glycerophosphocholine;GlycerylphosphorylcholineIbritumomab tiuxetan(E)--N--(3--(3--(4--Fluorophenoxy)phenyl)--1--(R,S)--methylprop--2--enyl)--N--hydroxyureaPro--Pro--ProMethylajoeneProxyphyllineEmodinLicheninPiroxantrone7--Hydroxy--6--methyl--8--ribityl lumazineGlycylserylprolylmethionylphenylalanylvalinamidegamma--Glutamylarginine5--Amino--6--(5''--phosphoribitylamino)uracilCarisoprodolCalcium palmitate;Palmitic acidGyromitrin1--[(5--Amino--5--carboxypentyl)amino]--1--deoxyfructose;Fructosyl--lysine;(2R)--2--Amino--6--[[(3S,4R,5R)--3,4,5,6--tetrahydroxy--2--oxohexyl]amino]hexanoic acidLysoPE(20:2(11Z,14Z)/0:0)Sulfobutyl etherCortisol(2S)--6--Amino--2--(hexanoylamino)hexanoic Acid6''''--O--MalonyldaidzinPhenylalanyltryptophanPhenylacetylglutamine;N(2)--phenylacetyl--L--glutaminateArctinone A acetate18R--hydroxy--5Z,8Z,11Z,14Z,16E--eicosapentaenoic acidBetaine7--[(4--Fluorophenyl)methoxy]--2,3--dimethyl--1--[(2--methylcyclopropyl)methyl]pyrrolo[2,3--d]pyridazineAbeadoMirtazapineN--Oleoyl ArginineStachyosePicumast19--Hydroxydeacetylnomilinic acid 17--beta--D--glucopyranoside--1--(beta--D--Ribofuranosyl)--1,4--dihydronicotinamide;(24R)--Cholest--5--ene--3--beta,24--diol2--(S--Glutathionyl)acetyl chlorideCitronellyl beta--sophorosideDynorphin B (6--9)Floionolic acidb--D--Glucuronopyranosyl--(1|right|3)--a--D--galacturonopyranosyl--(1|right|2)--L--rhamnoseSitosterol 3--O--(6''--O--stearyl--beta--D--glucoside)Androsta--1,4--diene--17--carboxylicacid, 17--[(ethoxycarbonyl)oxy]--11--hydroxy--3--oxo--, fluoromethyl ester, (11b,17a)--LysoPE(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)Cinnamic acid;trans--Cinnamic acid5--MethyldeoxycytidineApramycinO--(13--Carboxytridecanoyl)carnitinegamma--GlutamylhistidineFimasartanN--(8--Amino--1--carboxyoctyl)--alanyl--prolineAcetyl--Ser--Asp--Lys--ProLysoPE(18:0/0:0)Indicine--N--oxideKBT 1585 hydrochloridePS(22:2(13Z,16Z)/20:3(5Z,8Z,11Z))Apogossypolone1,2--Dihexanoyl--sn--glycero--3--phosphoethanolamine3--Feruloylquinic acidLysylhydroxyprolineCysteine--glutathione disulfide;Cysteineglutathione disulfide(S)--SuccinyldihydrolipoamideGenisteinKyotorphin;Tyrosyl--ArginineArg--Pro--Pro--Gly--Phe--Ser--ProPyridone 6Agavasaponin DL--Hypoglycin AAgavasaponin EOxmetidinePS(20:0/20:4(5Z,8Z,11Z,14Z))L--TryptophanOctylamineCefapime4--MethylbenzaldehydeAlectrolDeoxyspergualinN--gamma--L--Glutamyl--D--alanine;gamma--GlutamylalanineAdipic dihydrazideHydroxybuprenorphinePanose;1--KestoseN--Demethylmenogaril(2S,5R)--2,6--Diamino--5--[(2R,3R,4S,5R,6R)--3,4,5--trihydroxy--6--(hydroxymethyl)oxan--2--yl]oxyhexanoic acid;5--(Galactosylhydroxy)--L--Lysine;GalactosylhydroxylysineCDP--DG(20:3(5Z,8Z,11Z)/LTE4)GuanadrelPS(16:0/22:2(13Z,16Z))Pelanindelta--Tocotrienol2--Methylhippuric acid;Methyl hippurateThyminePiperalolNivacortolOleoylethanolamide3--DehydroteasteroneRetaspimycinCubebinNeogitogeninScorzosideSerylleucine;Ser--LeuFoetidissimoside BQuercetin 8--C--(2''''--rhamnosylglucoside)PGP(20:5(5Z,8Z,11Z,14Z,16E)--OH(18R)/a--15:0)Threonylhydroxyproline(R)--RuxolitinibMorpholine--4--carboxamideSeryllysineCrassostrea SecocarotenoidTaurineAmastatin8--Hydroxy--4(6)--lactarene--5,14--diolN--Acetyl--b--glucosaminylamineDL--Norvaline;NorvalineDhv--PGE21--(4--Aminophenyl)--7,8--dimethoxy--3--methyl--5H--2,3--benzodiazepin--4--onePE--NMe(20:4(5Z,8Z,11Z,14Z)/22:2(13Z,16Z))Leukotriene F4N2--Succinyl--L--glutamic acid 5--semialdehyde1--[(2R,3S,5R)--3,4--Dihydroxy--5--(hydroxymethyl)oxolan--2--yl]pyrimidine--2,4--dione21--DeoxycortisoneGuanosine 3''--monophosphate2--Amino--4--[carbamimidoyl(methyl)amino]butanoic acidLysoPC(P--18:0/0:0)ajugoseSM(d18:0/16:1(9Z))PiplartineNetilmicinAmabilineL--Aspartate--semialdehydeL--CarnitineMenthyl ethylene glycol carbonateFebuxostatPolythiazideLeukotriene E3Pentanedioic acid, 3--((((3R,5R)--3--butyl--3--ethyl--2,3,4,5--tetrahydro--7--methoxy--1,1--dioxido--5--phenyl--1,4--benzothiazepin--8--yl)methyl)amino)--Isoleucyl--AsparagineoxymetholonePS(18:1(11Z)/22:1(13Z))PG(22:6(5Z,8E,10Z,13Z,15E,19Z)--2OH(7S, 17S)/i--15:0)3--Amino--2,3--dihydrobenzoic acidLysoPC(20:4(8Z,11Z,14Z,17Z)/0:0)Hydroxyprolyl--ValinePS(O--20:0/14:1(9Z))Lofepramine;ImipramineStyreneD--Ribose 5--phosphateFluocortolone caproateGlycyl--prolyl--glutamic acidValyl--Gamma--glutamateSapienic acid(R)--1--Methylpiperidine--2--carboxylic acid14--HDoHEGlycyl--ArginineLF;Leucylphenylalanine11(R)--HETELevetiracetam;EtiracetamLeu--Pro--IleDL--Asparagine;L--AsparagineSaponin A5--HydroxyisourateSirolimusRicinoleic acidLentinanRacemethionine;L--MethionineCelastrolBiotin;Bioepiderm13,14--Dihydro PGF2aLysoPC(20:5(5Z,8Z,11Z,14Z,17Z)/0:0)Astragaloside IIILinoleamideAmmonia glutamate(16Z)--14--Hydroxydocos--16--enoylcarnitinePI(20:2(11Z,14Z)/TXB2)PhosphateL--Phenylalanine;D--PhenylalanineTriethanolamineProquazoneMG(10:0/0:0/0:0)Imidazolone APetroselinic acid;6--Octadecenoic acid;petroselinateMethoxamineArgininic acidPtaquilosideWithaferin APeroxynitriteDeoxyuridineDihydrozeatinZacoprideJesaconitineDL--Glutamate;L--Glutamic acid;D--Glutamic acidQuizartinibL--Alloisoleucine;L--IsoleucineDiacylglycerol kinase inhibitor i2--Hydroxy--3--methoxy--6beta--naltrexol3,5,7,8--Tetrahydro--2--[4--(trifluoromethyl)phenyl]--4H--thiopyrano[4,3--d]pyrimidin--4--one3--Oxo--2--(2--entenyl)cyclopentaneoctanoic acidAnonaine1--O--Hexadecyl--sn--glycero--3--phosphocholineV--Pyrro/NOUridine 5''--monophosphateL--Valine, N--(2--hydroxy--3--butenyl)--13--HODE;(13S)--13--hydroxyoctadeca--9,11--dienoic acidRacemethionineHexylamine2--(2--(4--Phenoxy--2--propylphenoxy)ethyl)indole--5--acetic acidEicosapentaenoic acidTiclopidine N--oxideAB--Pinaca4--(Aminobutyl)guanidine;Agmatinegamma--L--Glutamyl--S--(2--carboxy--1--propyl)cysteinylglycineEpanololL--Proline;DL--ProlineLysoPC(18:3(6Z,9Z,12Z)/0:0)Difloxacin3,5--Dichloro--2,6--dihydroxybenzoic acidRoxindole28--Homobrassinolide7,8--diaminopelargonateMaltotetraose4--DeacetylneosolaniolAminocaproic acidFluperlapineThreonylleucineThyrotropin releasing hormone;Thyrotropin--releasing factor;4--MethoxyestroneL--Acetylcarnitine;DL--AcetylcarnitineGlutaminyllysineSpergualinOctopineCytosineIndoleacrylic acidIsoleucyl--GlutamateS--(PGA1)--glutathioneMonoelaidin;MG(18:1(9Z)/0:0/0:0)gamma--CEHCCynaroside ADaucolApigenidin;ApigeninidinN--(N--(3--Amino--3--carboxypropyl)--3--amino--3--carboxypropyl)azetidine--2--carboxylic acidSteviobiosideGibberellin A20 13--glucosideLysoPE(P--18:1(9Z)/0:0)Lovastatin acidAsparaginyl--ProlineValylleucinePS(20:4(8Z,11Z,14Z,17Z)/22:0)O--Desmethyltramadol glucuronideGlutaminylphenylalanineOxidized glutathione;Cytidine 2'',3''--cyclic phosphate(S)--10,16--Dihydroxyhexadecanoic acidS--(9--hydroxy--PGA1)--glutathioneMycophenolic acid O--acyl--glucuronideL--Aspartic acid;D--Aspartic acid8--Hydroxy--deoxyguanosine23--AcetoxysoladulcidinePS(18:3(9Z,12Z,15Z)/22:1(13Z))1--Octen--3--yl primeverosideCarglumic acidPelanin;Estradioltrans--zeatin riboside;9--(beta--D--Ribofuranosyl)zeatinSuccinic acidLysoPC(18:2(9Z,12Z)/0:0)HypoxanthineInosine;Ara--HXL--HistidineSenecionine N--oxideisoleucyl--thiazolidine6--Oxopiperidine--2--carboxylic acidApronalLinarinEnterolactonegamma--GlutamylfelinylglycineRocuronium(2S)--1--[2--[[(2S)--Pyrrolidine--2--carbonyl]amino]acetyl]pyrrolidine--2--carboxylic AcidPE(22:2(13Z,16Z)/15:0)4--Hydroxyphenylacetylglutamic aciddelta--Hydroxylysylnorleucinehesperetin 3''--O--sulfate3--Formyl Rifamycintrans--Cinnamyl alcoholHomocarnosineN--(4--Hydroxyphenyl)--3,7--dimethyl--9--(2,6,6--trimethyl--1--cyclohexenyl)nona--2,4,6,8--tetraenamideNemifitideCicaprost8--Amino--7--oxononanoic acidCholylmethionineBenzoic acid;Benzaldehyde;Benzamide;benzoate;3,5--Dihydroxybenzoic acid;Potassium benzoate;2,6--Dihydroxybenzoic acidProlyl--Gamma--glutamateArctiolDammePhosphoramidonGlycerophosphoinositol3''--DeoxyderhamnosylmaysinPA(10:0/i--12:0)(R)--N--MethylsalsolinolSphingosine 1--phosphate (d16:1--P)(2S,4R,6S)-2-[2-(4-hydroxy-3-methoxyphenyl)ethyl]tetrahydro-6-(4-hydroxy-3,5-dimethoxyphenyl)-2H-pyran-4-olLysoPC(16:0/0:0)MG(0:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)VerbascoseCalpeptinSclareol;Sclareol oxideDedimethylchlorpromazineTulathromycin A1,1,1--Trifluoro--3--hydroxypropan--2--oneMadecassoside(±)--(Z)--2--(5--Tetradecenyl)cyclobutanoneDG(8:0/PGJ2/0:0)Triferric doxorubicin;Doxorubicin4--Hydroxyquinoline4--(Methylnitrosamino)--1--(3--pyridyl)--1--butanol glucuronideDavercin6--Ketoprostaglandin E1Val--CitParomomycin I;ParomomycinGlucose pyruvate lactateRogletimideBilinCentpropazineDihydrogenisteinGolotimod;gamma--Glutamyltryptophanhydroxyethyl methacrylic acid;2--Hydroxyethyl methacrylateSparfosic acid7alpha,25--Dihydroxy--4--cholesten--3--oneTestosterone glucuronide;Testosterone 17b--(b--D--glucuronide)Nicotinic acid;Nicotinuric acidValylasparaginePerylene--1,2--dioneGlyceryl monolinoleateGeniposidic acid(3b,5a,25R)--3--Hydroxyspirostan--6--one 3--[2--acetylarabinosyl--(1|right|6)--glucoside]DebrisoquineSoyasaponin I12,13--EpOME9,10--DHOMEDiaziquoneCucurbitacin BSebacic acidMelezitose2--[2--[(1--Ethoxy--1--oxo--4--phenylbutan--2--yl)amino]propanoyl]--6,7--dimethoxy--3,4--dihydro--1H--isoquinoline--3--carboxylic acid;MoexiprilL--Proline, 1--acetyl--4--hydroxy--, cis--DG(18:0/PGE2/0:0)Pipecolic acid;L--Pipecolic acidSoyasaponin VDelpazolidValylhydroxyproline10--Nitrolinoleic acidErgothioneineKanamycin;Aminodeoxykanamycin9--OxoODECellobiosideCoutaric acid5--(3'',5''--Dihydroxyphenyl)--gamma--valerolactone--O--sulphate--O--methyl1--Pentyl--3--(4--methoxybenzoyl)indoleUridine 2'',3''--cyclic phosphateL--Serine2--FurancarboxaldehydePS(18:0/22:0)o6--Benzyl--8--oxoguanine1--Arachidonoylglycerol;MG(20:4(5Z,8Z,11Z,14Z)/0:0/0:0)ArginylserineMG(0:0/18:2(9Z,12Z)/0:0)AspartylglycosamineParamethasoneCorynantheineMethyl (3x,10R)--dihydroxy--11--dodecene--6,8--diynoate 10--glucoside3--[[(2S)--2,4--Dihydroxy--3,3--dimethylbutanoyl]amino]propanoic acid;Pantothenic acidepsilon--(gamma--Glutamyl)--L--lysineTetrahydrodeoxycortisolbeta--D--Galactopyranosyl--(1|right|4)--beta--D--galactopyranosyl--(1|right|4)--D--galactose;MaltotrioseScopolaminePC(20:5(5Z,8Z,11Z,14Z,17Z)/18:1(11Z))GrepafloxacinCyclooctaneCarteololN--Acetyl--a--neuraminic acid(±)--2--Hydroxy--4--(methylthio)butanoic acidCyclopentanolTocainideD--Glucaro--1,4--lactonePolyribosylribitolphosphateFluocinoloneD--GlucosaminideL--DopaD--myo--Inositol 4--phosphateRUCAPARIB5--Amino--2--oxopentanoic acid(3S)--3,6--DiaminohexanoatePG(18:1(12Z)--2OH(9,10)/a--21:0)Caprylic acid;Potassium octanoate;octanoateBlasticidin SN(2)--phenylacetyl--L--glutaminateN--Eicosapentaenoyl ThreonineToxin T2 tetrolCapsidiolMethyl 16--hydroxyhexadecanoateLysoPI(18:1(9Z)/0:0)Valylmethionine;Val--Met3--MethylcrotonylglycineTranexamic Acid(3R,4R,5R)--3--Fluoro--5--(hydroxymethyl)oxolane--2,3,4--triol3--O--Methylniveusin ARHODAMINE 6GL--Leucine9,10,13--TriHOMES--aminomethyldihydrolipoamideValylphenylalanine;N--ValylphenylalanineNandrolone(2S,4R,5S)--MuscarineCysteinyl--ArginineAsparaginyl--LeucineSoyasaponin aaMalic acidAsymmetric dimethylarginineGlycyl--proline--1--naphthylamideEdta citrate6--Benzylaminopurine1,4,10,13--Tetraoxa--7,16--diazacyclooctadecaneLysoPE(16:0/0:0)Empagliflozin12--Oxo--c--LTB3AlanylprolineFuzilineBenzaldehydeTETRAHYDROURIDINEPhosphorylcholineAlanyllysineHistamineSetipafantFasoracetamCyclosquamosin CLysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)Lucuminamidegamma--GlutamylphenylalanineO--Galactosyl--5--hydroxylysineMabioside C1--Methoxypyrene2--Phenylacetamide4--Methyl--1,4--dihydropyridine--3,5--dicarbaldehyde5,6--DHETCDP--DG(18:2(9Z,11Z)/i--15:0)Methionine sulfoxideN--Methyl--14--O--demethylepiporphyroxineIsolithocholic acid10--Hydroxydecanoic acidSoyasaponin IIIJasmoloneCynaropicrinAzelaic acid20--Hydroxy--leukotriene E41--(2--Aminoacetyl)--N--(4--nitrophenyl)pyrrolidine--2--carboxamide2--Anthraquinonesulfonic acidMG(18:3(9Z,12Z,15Z)/0:0/0:0)PiperidinePerillic acidAminopropanol;1--Amino--propan--2--ol1H--Imidazole--4--carboxamidewortmanninHomomethionine4--Ketoretinoic acid glucuronideS--(11--hydroxy--9--deoxy--delta12--PGD2)--glutathionePC(22:5(7Z,10Z,13Z,16Z,19Z)/18:2(9Z,12Z));PC(22:5(4Z,7Z,10Z,13Z,16Z)/18:2(9Z,12Z))DethiobiotinMaltohexaoseDG(PGF1alpha/i--14:0/0:0)OPC4--CoACholine;Choline sulfate2--Piperidinone(R)--1--Octen--3--olLubiprostoneDaidzeinTobramycinProstaglandin F1aAsiaticosidefalseResponse Mechanisms of Hepatopancreatic Metabolism and Gut Microbiota in Chinese Mitten Crab (Eriocheir sinensis) Under Chronic High-pH StressThis study subjected Eriocheir sinensis to chronic high-pH stress (control: pH=8; experimental groups: pH=9 and pH=10) and integrated hepatopancreas transcriptomic/metabolomic analyses with intestinal microbiota 16S rRNA sequencing to explore its adaptive mechanisms. The results revealed distinct adaptive strategies across stress phases: under short-term (15 days) high-pH stress, E. sinensis maintained somatic homeostasis mainly via rapid regulation of carbohydrate, lipid, protein metabolism, and energy allocation. In contrast, long-term (30 days) stress drove a strategic shift toward accelerated lipid catabolism, enhanced energy metabolism, and activated immune-related pathways. Additionally, high-pH stress significantly altered the intestinal microbiota community structure, marked by increased abundances of Proteobacteria and Pseudomonas, indicating a potential risk of microbial dysbiosis. Collectively, these findings elucidate the physiological adaptation mechanisms of E. sinensis to high-pH environments and lay a theoretical foundation for improving the sustainability of its aquaculture under extreme pH conditions.2026-07-042026-01-17MTBLS13708HMDB0061693HMDB0033412HMDB0258406HMDB0032839HMDB0251430HMDB0094195;PW_C064372HMDB0112672;PW_C061093HMDB0242382HMDB0014775;PW_C009122HMDB0303376HMDB0116760;PW_C060920HMDB0030423HMDB0304803HMDB0011483HMDB0014743;PW_C009093;HMDB0246228HMDB0000717;LMST04010004HMDB0004239HMDB0245603HMDB0032538HMDB0015180HMDB0255618HMDB0032323HMDB0255916HMDB0030325HMDB0036998HMDB0031299HMDB0035780HMDB0030504HMDB0002725;LMST02010044HMDB0304236HMDB0301955HMDB0241603HMDB0029087HMDB0002385HMDB0013624HMDB0015073HMDB0297127HMDB0035287HMDB0010382HMDB0031043;LMFA05000640HMDB0112401;PW_C060802HMDB0036827;HMDB0258180HMDB0002088HMDB0005972;LMST05030014HMDB0010394HMDB0256048HMDB0254562HMDB0256016HMDB0013464HMDB0240219;LMFA01030076HMDB0000567;HMDB0000930HMDB0037798HMDB0251112HMDB0006547;PW_C002804;LMFA01030357HMDB0244587HMDB0112776;PW_C061204HMDB0040653HMDB0010379;LMGP01050012HMDB0242528HMDB0304265HMDB0010387HMDB0041185HMDB0301805HMDB0113443;PW_C059569HMDB0252832HMDB0250661HMDB0304547;HMDB0002059HMDB0304805HMDB0032051HMDB0030130;HMDB0303698HMDB0241954HMDB0000222;HMDB0240783;LMFA07070004HMDB0247705HMDB0062399;LMST04030171HMDB0256858HMDB0039331HMDB0254854;HMDB0011567HMDB0000734HMDB0000482;PW_C000366;HMDB0303345;HMDB0304443;LMFA01010008HMDB0248674HMDB0245289HMDB0257122HMDB0247956;HMDB0015224;HMDB0031448;LMST01120022HMDB0004710HMDB0252399HMDB0243514HMDB0030039HMDB0034535HMDB0252558HMDB0034927;LMST01010104HMDB0013059HMDB0030341;MJDBOTE0001611HMDB0013061HMDB0060154HMDB0033242HMDB0304176HMDB0011493HMDB0001140;LMFA06000028HMDB0257485HMDB0011640HMDB0039517HMDB0013302HMDB0115611;PW_C063996HMDB0040896HMDB0031876HMDB0060061HMDB0040122HMDB0258592HMDB0277769HMDB0041263HMDB0247737HMDB0242512;HMDB0015490HMDB0248277HMDB0304801HMDB0250724HMDB0014794HMDB0303648;HMDB0000151;PW_C000098;MJDBOTE0000772HMDB0030407HMDB0298918HMDB0030984HMDB0258793;LMST01130025HMDB0257289HMDB0295863HMDB0254039;HMDB0028933HMDB0248578HMDB0241876HMDB0040505HMDB0011580HMDB0252688HMDB0014617HMDB0253013HMDB0028983HMDB0029427HMDB0000459HMDB0035767HMDB0000030;HMDB0249220HMDB0246466HMDB0255508HMDB0253951HMDB0253927HMDB0002184HMDB0247158HMDB0274430HMDB0256406HMDB0000632;HMDB0060470HMDB0062470HMDB0015333;HMDB0252105HMDB0253404HMDB0032311HMDB0301801HMDB0029133;HMDB0259742HMDB0001177HMDB0005773HMDB0273372HMDB0032601HMDB0001894;MJDBOTE0001640HMDB0003573;MJDBOTE0001028HMDB0260136HMDB0246113HMDB0252610HMDB0041372HMDB0251123HMDB0000262;PW_C000179;MJDBOTE0000713HMDB0000851HMDB0034879HMDB0002171HMDB0014447;PW_C008836;MJDBOTE0000780HMDB0000070;HMDB0000716;PW_C000567HMDB0254370HMDB0256689HMDB0257763HMDB0000557;HMDB0000172;PW_C000112;MJDBOTE0001077HMDB0259902HMDB0028906HMDB0060044HMDB0246915HMDB0029141HMDB0248706HMDB0304812HMDB0251887;HMDB0240347HMDB0253265;HMDB0245159HMDB0255791;HMDB0015132;PW_C009432HMDB0242690HMDB0028889;HMDB0253179HMDB0246131HMDB0247783HMDB0033951;HMDB0000696;PW_C000548;MJDBOTE0001368HMDB0037115HMDB0012215;MJDBZSJ0000131HMDB0248473HMDB0252908;HMDB0029160HMDB0001488;PW_C001145;HMDB0003269;MJDBOTE0000774HMDB0033253;LMPR0103400001HMDB0000767HMDB0260392HMDB0028876HMDB0003337;HMDB0011691HMDB0001397;MJDBOTE0000666HMDB0255025HMDB0029062HMDB0000201;HMDB0240773HMDB0029128HMDB0304260HMDB0252139HMDB0248312HMDB0000745HMDB0000630;MJDBOTE0000458HMDB0011113HMDB0303648HMDB0003045HMDB0014539HMDB0242107HMDB0006272;PW_C002698;LMFA01060169HMDB0032914HMDB0257064HMDB0006061HMDB0240650;MJDBOTE0001351HMDB0257780HMDB0248356HMDB0028739HMDB0061705HMDB0254150;HMDB0001848HMDB0006488HMDB0244223HMDB0030417HMDB0253913HMDB0248330;HMDB0012136HMDB0012249HMDB0252185HMDB0251527;HMDB0013716HMDB0000062;PW_C000044;MJDBOTE0000806HMDB0060475;PW_C000095;HMDB0000148;HMDB0003339HMDB0015673HMDB0003333HMDB0000569HMDB0000641;HMDB0003423;PW_C000500;MJDBOTE0000775HMDB0000191;PW_C000123HMDB0249803HMDB0249268HMDB0302463HMDB0248342HMDB0255111HMDB0034942;LMPR0102070043HMDB0003148HMDB0247743HMDB0255374HMDB0248014HMDB0246298;HMDB0001432;MJDBOTE0000469HMDB0259734HMDB0040532HMDB0246425HMDB0028692HMDB0039728HMDB0028894HMDB0257624HMDB0304612;LMPK12050204HMDB0252533HMDB0015419;PW_C009694HMDB0012114HMDB0256354HMDB0243769HMDB0246151;HMDB0242167;HMDB0000600HMDB0303165HMDB0303467HMDB0000052;PW_C000036HMDB0011570HMDB0302194HMDB0029638HMDB0257989HMDB0003337;PW_C001847;HMDB0011691;MJDBOTE0000407HMDB0249793HMDB0034240HMDB0028822HMDB0248536HMDB0302266HMDB0258762HMDB0030810HMDB0034649HMDB0038721HMDB0244267HMDB0072866HMDB0011513HMDB0250707;HMDB0000656HMDB0011526HMDB0005998;PW_C002614HMDB0031402HMDB0011538HMDB0011557;LMGL01010027HMDB0028896HMDB0036141HMDB0252352HMDB0252353HMDB0258260HMDB0000097;HMDB0250194;PW_C000065;MJDBOTE0000238HMDB0031152HMDB0060491;PW_C040621HMDB0255801HMDB0028805HMDB0250477HMDB0250509HMDB0302307HMDB0243998HMDB0012469;HMDB0003626HMDB0243598HMDB0002362;HMDB0006284HMDB0001539HMDB0251519HMDB0041970HMDB0000162;PW_C000106;HMDB0251528;MJDBOTE0000527HMDB0031670HMDB0001180HMDB0011730;MJDBOTE0000489HMDB0302349HMDB0253190HMDB0000086;HMDB0252858HMDB0001870;HMDB0006115;HMDB0004461;HMDB0304270;HMDB0013677;HMDB0303719;HMDB0013676;MJDBOTE0000832HMDB0243830;HMDB0011578;LMGL01010032HMDB0033952HMDB0259738HMDB0012558HMDB0040713HMDB0003626HMDB0011723;HMDB0000859HMDB0038614HMDB0000157;PW_C000102HMDB0001931HMDB0029365HMDB0241796HMDB0034301HMDB0011648;HMDB0011643HMDB0247929HMDB0029104HMDB0039238;MJDBZSJ0000113HMDB0031791HMDB0257571HMDB0035593;HMDB0302980HMDB0302358HMDB0006115HMDB0028952HMDB0247063HMDB0011749HMDB0271429HMDB0010715HMDB0014892HMDB0060856;PW_C040591HMDB0006465;LMFA03020009;LMFA03020076HMDB0029936HMDB0038120;HMDB0246031HMDB0001901;PW_C001268HMDB0013055HMDB0245157HMDB0277936HMDB0028941HMDB0004586;LMPR0102090041HMDB0029006HMDB0062656;LMFA08010008HMDB0037543HMDB0256490HMDB0242115;LMGL01010006HMDB0303647;LMPK12010030HMDB0014662;PW_C009020HMDB0247381HMDB0029225HMDB0259481HMDB0243900HMDB0012937HMDB0242001HMDB0259981HMDB0003312;LMPK12050038;MJDBOTE0000779HMDB0015303;HMDB0242522HMDB0014934;PW_C009260;MJDBOTE0000872HMDB0014822;PW_C009161HMDB0257483;LMFA01030267HMDB0034297HMDB0258417HMDB0000036;LMST05040001;PW_C000025;MJDBOTE0000483HMDB0034651HMDB0116055;PW_C076391HMDB0302069HMDB0029698HMDB0304641HMDB0270896HMDB0009578HMDB0037789HMDB0010396HMDB0114747HMDB0060099HMDB0034295;LMFA02000147HMDB0038028HMDB0303118HMDB0002685HMDB0011130HMDB0302897HMDB0011144HMDB0031851HMDB0001565HMDB0014634;MJDBOTE0000907HMDB0256542HMDB0008697;HMDB0008664HMDB0259324HMDB0240599HMDB0302627HMDB0243890;LMGP01060010HMDB0004704HMDB0247864HMDB0258750HMDB0030348HMDB0251835HMDB0030097HMDB0031752HMDB0252303HMDB0001198;HMDB0005095;PW_C000933;LMFA03020003HMDB0252835HMDB0010385HMDB0243776HMDB0255434HMDB0060077HMDB0060425HMDB0240587HMDB0127731HMDB0030682HMDB0249843HMDB0003841HMDB0036656;MJDBOTE0000921HMDB0035984HMDB0000784;LMFA01170054;MJDBOTE0000344HMDB0039296HMDB0249490HMDB0256971HMDB0259924HMDB0033807HMDB0277209HMDB0244564HMDB0245031HMDB0253732HMDB0244074;LMGP02010104HMDB0000012HMDB0252174HMDB0000195;PW_C000127;HMDB0247301;MJDBOTE0000386HMDB0257468HMDB0003581HMDB0242080HMDB0036707HMDB0254077HMDB0253148HMDB0029143HMDB0000594HMDB0028695HMDB0301837HMDB0061689HMDB0029131HMDB0249207HMDB0257199HMDB0039469HMDB0000929;PW_C000741;MJDBOTE0000426HMDB0028848HMDB0253331HMDB0245144HMDB0029065HMDB0249387HMDB0252953HMDB0247289;LMPK12020230HMDB0249522HMDB0030452HMDB0002331HMDB0253458HMDB0252619HMDB0245578HMDB0030084HMDB0029394HMDB0249750HMDB0014509HMDB0252788HMDB0252687HMDB0036561HMDB0000133;PW_C000087;MJDBOTE0000372HMDB0062645HMDB0002224HMDB0029042HMDB0030171HMDB0060031HMDB0004304HMDB0000773HMDB0006239;LMFA08010025HMDB0000288;MJDBOTE0000717HMDB0244880HMDB0242164HMDB0037589HMDB0254010HMDB0251706HMDB0038871HMDB0028804HMDB0001296;MJDBOTE0000277HMDB0001313HMDB0257731HMDB0252776HMDB0000296;PW_C000202;MJDBOTE0000788HMDB0031758HMDB0259784HMDB0036159HMDB0000014;HMDB0250725;PW_C000008HMDB0248524HMDB0000489HMDB0028798HMDB0029122HMDB0028769HMDB0029937;HMDB0011729HMDB0060080;HMDB0259062;HMDB0060088HMDB0029247HMDB0000656HMDB0243580HMDB0255912HMDB0254886HMDB0242167HMDB0245586HMDB0028898HMDB0257277HMDB0249913HMDB0014861HMDB0248553;HMDB0015122HMDB0031863HMDB0030406HMDB0001429;PW_C001104HMDB0029151HMDB0000191;HMDB0006483;MJDBOTE0000530HMDB0251512;PW_C000110;HMDB0000168;MJDBOTE0000518HMDB0255877HMDB0000645HMDB0034879;HMDB0252495;HMDB0242138HMDB0000187;PW_C000120HMDB0253421HMDB0028802HMDB0028835HMDB0250531HMDB0254097;LMPK12110449HMDB0061134HMDB0029023HMDB0028846HMDB0304625HMDB0257319HMDB0029812HMDB0252347HMDB0029044HMDB0012253HMDB0029933HMDB0010381;HMDB0010375HMDB0029084HMDB0250840HMDB0254177HMDB0256878HMDB0257445HMDB0011477HMDB0256951HMDB0248130HMDB0015462HMDB0251076HMDB0255670HMDB0259748HMDB0013889HMDB0250231HMDB0060899HMDB0028718HMDB0011649HMDB0001548;PW_C001191HMDB0036423HMDB0005897HMDB0000052HMDB0003903HMDB0254895HMDB0011173HMDB0039084HMDB0251259HMDB0036301;HMDB0006248HMDB0303603HMDB0028902HMDB0029031HMDB0011172HMDB0000030;PW_C000020;MJDBOTE0000823HMDB0258230HMDB0006543HMDB0033951HMDB0031697HMDB0256611HMDB0028735HMDB0005768;HMDB0029099HMDB0060324HMDB0258326HMDB0002641;HMDB0041592HMDB0014371HMDB0249563HMDB0029045HMDB0029840HMDB0006344;HMDB0062645;PW_C002728;MJDBOTE0000584HMDB0004270HMDB0006101HMDB0245298HMDB0251778HMDB0004081;PW_C002052HMDB0253651HMDB0250974HMDB0060383HMDB0029043;HMDB0258242HMDB0252829HMDB0244272HMDB0251157HMDB0247746HMDB0256095HMDB0253034HMDB0249447HMDB0296926HMDB0251872HMDB0252259HMDB0029134;HMDB0255244HMDB0011171HMDB0302357HMDB0060475;HMDB0000148;HMDB0003339HMDB0257333;PW_C009168;HMDB0014829HMDB0028711HMDB0003193;HMDB0258856HMDB0302841;HMDB0013243HMDB0240687;LMFA01060168HMDB0029202HMDB0291941HMDB0015015;LMPK06000003HMDB0033814HMDB0001104HMDB0036252HMDB0303074;HMDB0301880HMDB0041862HMDB0036158HMDB0036157HMDB0035214;LMPK13040008;MJDBOTE0001470HMDB0029368HMDB0257361HMDB0301778HMDB0258911HMDB0041527;LMST01030131HMDB0304506;HMDB0030388HMDB0240471HMDB0031751HMDB0243698HMDB0038852;HMDB0001262;MJDBOTE0000606HMDB0256848HMDB0248169HMDB0010397HMDB0010404HMDB0259867HMDB0014866HMDB0002179HMDB0245874HMDB0251150HMDB0303090HMDB0257169HMDB0248529HMDB0060547HMDB0030669HMDB0254187HM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