MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/m_MTBLS13715_LC-MS_alternating__metabolite_profiling_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/a_MTBLS13715_LC-MS_alternating__metabolite_profiling.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/s_MTBLS13715.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/Ctr3.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/Ctr1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/QC3.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/Ctr5.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/PGaDH4.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/PGaDH2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/QC5.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/Ctr2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/QC6.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/Ctr4.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/QC4.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/Ctr6.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/QC2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/PGaDH1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/PGaDH6.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/PGaDH5.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/QC1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715/FILES/RAW_FILES/PGaDH3.rawprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13715<p>Metabolites were extracted and profiled by LC-MS. Differential metabolites were identified using VIP &gt; 1.0 and p &lt; 0.05 and analyzed for pathway enrichment through the Suzhou Panomix Biomedical Technology Co., Ltd’s cloud-based platform.</p>MetaboLightsPublicLiquid Chromatography MS - alternating<p>The LC analysis was performed on a Vanquish UHPLC System (Thermo Fisher Scientific, USA).</p><p>Chromatography was carried out with an ACQUITY UPLC HSS T3 Column (2.1 × 100 mm, 1.8 μm)</p><p>(Waters, Milford, MA, USA). The column maintained at 40 ℃. The flow rate and injection volume</p><p>were set at 0.3 mL/min and 5 μL, respectively.</p>Spatiotemporal iron-hijacking hydrogel reprograms host-pathogen iron homeostasis for fungal keratitis therapy.Zhejiang universityJian HeCandida albicansmass spectrometry assay<p>1. Accurately weigh an appropriate amount of sample into a 2 mL centrifuge tube,add 10 0 mg</p><p>glass bead;</p><p>2. Add 1000 µL 50% methanol water, vortex for 30 s;</p><p>3. Put the centrifuge tube containing the sample into the 2 mL adapter matched with the</p><p>instrument, immerse it in liquid nitrogen for rapid freezing for 5 min, take out the centrifuge tube</p><p>and thaw at room temperature, put the centrifuge tube into the 2 mL adapter again, install it into</p><p>the tissue grinder and grind it at 55 Hz for 2 min;</p><p>4. Repeat step 3 twice;</p><p>5. Take out the centrifuge tube, centrifuge for 10 min at 12,000 rpm and 4 ℃℃, take all the</p><p>s upernatant, transfer it to a new 2 mL centrifuge tube, concentrate and dry it;</p><p>6. Accurately add 300 µL of 2 Amino 3 --(2 chloro phenyl) propionic acid (4 ppm) solution</p><p>prepared with 50% methanol water to redissolve the sample, filter the supernatant by 0.22 μ m</p><p>membrane and transfer into the detection bottle for LC MS detection.</p>Candida albicanshttps://www.ebi.ac.uk/metabolights/MTBLS13715Zhou Min. Zhejiang university. zhoum@zju.edu.cn.He Jian. hejianhj@zju.edu.cn.<p>Metabolites were extracted and profiled by LC-MS. Differential metabolites were identified using VIP &gt; 1.0 and p &lt; 0.05 and analyzed for pathway enrichment through the Suzhou Panomix Biomedical Technology Co., Ltd’s cloud-based platform.</p>Grouphejianhj@zju.edu.cn<p><em>Candida albican treated with PGaDH</em> were collected, immediately frozen in liquid nitrogen, and stored at −80 °C until analysis.Untargeted metabolomics analysis was performed on Candida albican samples.</p>MetabolomicsIron homeostasisCandida albicansIron Chelating Agentsuntargeted metabolitesIron homeostasisCandida albicansIron Chelating Agentsuntargeted metabolites<p>Mass spectrometric detection of metabolites was performed on Orbitrap Exploris 120 (Thermo</p><p>Fisher Scientific, USA) with ESI ion source. Simultaneous MS1 and MS/MS (Full MS-ddMS2 mode,</p><p>data-dependent MS/MS) acquisition was used. The parameters were as follows: sheath gas</p><p>pressure, 40 arb; aux gas flow, 10 arb; spray voltage, 3.50 kV and -2.50 kV for ESI(+) and ESI(-),</p><p>respectively; capillary temperature, 325 ℃ ; MS1 range, m/z 100-1000; MS1 resolving power,</p><p>60000 FWHM; number of data dependant scans per cycle, 4; MS/MS resolving power, 15000FWHM; normalized collision energy, 30%; dynamic exclusion time, automatic</p>S-AdenosylmethioninaminedGDPPhenylpyruvateThymidine-5'-monophosphoric acidGentamicinAnatabine1,3-dihydroxy-N-methylacridone14-apo-beta-carotenalACMC-20my24Ectoine1-AdgmiL-HistidineInositol cyclic phosphate2-Methyl-2-vinyloxiraneCitrullinedapdiamide AFlavin mononucleotideMethyl indole-3-acetateS-(2-Methylpropionyl)-dihydrolipoamide-EN-Methylethanolaminium phosphateGaleginecis-p-Coumaric acidMethylimidazole acetaldehyde6,8-Dimethyl-6,7-didehydroergolinePantoatedapdiamide C4-HydroxybenzaldehydePicolinamideRoquefortine L3,5-Dichloro-2-methylmuconolactoneProstaglandin E1VermelonePinostilbene4,4-Diaponeurosporen-4-alN2-Succinyl-L-ornithine3,4-Dihydroxymandelic acidDihydroneopterin phosphateFA 18_3;O3D-Xylulose-5-phosphateMevalonic acidFrangulin BRicinineTaurohyocholateAbscisic alcoholgamma-Butyrolactone6-DeoxocastasteroneGlutathione3-VinylcatecholCaffeic acid(-)-ThebainePlastoquinol AOleamide3-phosphoglyceratePalmitaldehyde6-deoxyerythronolide BLidocainePluviatolide(3E,7E)-4,8,12-Trimethyl-1,3,7,11-tridecatetraenePantothenic acid2-Oxo-4-methylthiobutanoic acid(22alpha)-Hydroxy-campest-4-en-3-oneGlycerol 3-phosphate7,7',8,8'-Tetrahydrolycopene6-Benzylaminopurinecis-1,2-Dihydro-3-ethylcatechol5-CarboxyuracilD-UrobilinDibenzothiophene sulfone19-epi-Cathenamine(S)-3-Amino-3-phenylpropanoic acid2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamidePiperideineVanillic acidCanthaxanthinPhthalic acidalatolide2-Thioxo-4-thiazolidinoneDeoxyribose 5-phosphateDiethylthiophosphateSCHEMBL1662013810R-HpODEIsopiperitenol2-Cyclohexen-1-one2,4-QuinolinediolOxidized glutathionechrysoplenol DNaringin2-PentanoneFormamidopyrimidine nucleoside triphosphatetricoumaroyl spermidine1,3-BenzenediolChenodeoxycholic acidAndrostenedioneOrnithinePyridoxate4,6-Dichloro-3-methylcatechol3-Hydroxybenzoic acid2-Naphthyl beta-D-glucopyranoside1,2-Dihydroxy-3-keto-5-methylthiopenteneIndoleDesethyl atrazineIronMenatetrenoneGentisate aldehydebeta-IononeP-Hydroxyphenylethanolamine2-Octaprenyl-6-methoxy-1,4-benzoquinonePlumbaginTigloidineFuranone A8,8a-Deoxyoleandolide3,5-Dibromo-4-hydroxybenzoateAcetyl-N-formyl-5-methoxykynurenamineCyclopentolateS-FormylmycothiolPE(18_0_20_4(5Z,8Z,11Z,14Z))AdenosineAdenosine monophosphate1-epi-Valienol 7-phosphate2,4,5-TrihydroxytolueneMillettoneL-AlloisoleucineBornyl_acetateUric acidIndolepyruvateMexiletinePterostilbeneLinoleic acid(S)-2-AcetolactateDibucaineHomo-L-arginineCiliatocholic acid2-Deoxy-D-gluconateBenzoic acidMelatoninL-PhenylalanineDodecanamideOxaloacetate4-Methylumbelliferyl acetate4-AminobutyraldehydeDocosahexaenoic acidHydantoin-5-propionic acid10-DeoxymethynolideO-Acetylserine4-(Glutamylamino) butanoatebeta-L-FucoseadonirubinPropanoyl phosphate(R)-2,3-Dihydroxy-3-methylvalerateUridine diphosphate glucosebornane-2,6-dione3-DehydrosphinganineBiphenylHallactone B4-FluorocatecholCarbendazim(S)-10,16-Dihydroxyhexadecanoic acidGibberellin A9Terephthalic acidImidazole lactic acidN-MalonyltryptophanZeatinTyrosine methylesterXanthoxylolL-Cystathionine3-Hexaprenyl-4,5-Dihydroxybenzoic acid10-DeoxymethymycinFA 12_2;OPyruvatoximeGeranyl acetate2-(4-methylthio)butylmalateFarnesyl pyrophosphatepyrethrin IUmbelliferone[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonateST 28_1;O3DIMBOA-Glc2,6,7,4-TetrahydroxyisoflavanoneN1-hydroxy-roquefortine CSterigmatocystin(25S)-3-oxocholest-4-en-26-alPhaseollidinCiticolineAmidinostreptamineXanthosineUridine 5'-monophosphateCitric acid4-Methoxy-2,2-bipyrrole-5-carboxaldehydeACMC-20m5rpHydroxymethylphosphonateomega-Hydroxyphylloquinone8-MethylnonenoateAtrazineIsopentyl acetate3-Methyl-2-butenalRetinyl palmitate1-nitrosonaphthalene2-DeoxystreptamineN4-Acetylaminobutanal5-methylthioadenosine (MTA)Tauroursodeoxycholic acidInosine 5'-monophosphate (IMP)brevianamide FPipecolic acidO-Phospho-4-hydroxy-L-threonine[(3S,4S,5S,6R)-3,4,5,6-tetrahydroxycyclohexen-1-yl]methyl dihydrogen phosphateS-adenosylhomocysteine (SAH)DiketopiperazineHomovanillin2-Deoxyinosose(2R,3R)-Dihydroflavonol7-DehydrocholesterolIndole-3-carboxaldehydeStearic acidFlavin adenine dinucleotide2-Oxazolidinone2-Aminobiphenyl-2,3-diolUDP-N-Acetyl-D-galactosamineCyclohexanNitrilotriacetic acid2E-Dodecenedioic acid1-deoxy-L-glycero-tetrulose 4-phosphateNeurosporaxanthinTetracenomycin B1FA 11_1Glycolithocholate sulphateCarnitineHydroquinoneCirsimaritin2-(beta-D-Glucosyl)-sn-glycerol 3-phosphate3-Methoxy-4-hydroxyphenylglycolaldehydeOrientinIodomethaneCaffeoylmalic acidEcgonine methyl esterLeucodopachrome(1S,3S,12S,14R,27S)-12-hydroxy-1,3-dimethyl-2,5,15,23,25-pentazaheptacyclo[12.10.2.12,5.06,11.015,24.017,22.012,27]heptacosa-6,8,10,17,19,21,23-heptaene-4,16,26-trioneD-1,5-AnhydrofructoseEpimelibioseHaloperidolPropylthiouracilPyrimethanilandrost-5-ene-3,17-dioneTiagabine3-Sulfopropanediol(Z)-4',6-DihydroxyauroneSCHEMBL12391563Protoanemonin2,2,6,6-Tetranitro-4,4-azoxytolueneRiboflavin (Vitamin B2)Aconitate [cis or trans]AcetoacetateL-Oleandrosyl-oleandolideFluorouracil5-Phosphoribosylamineprotoemetine¦Ã-Aminobutyric acidThymine1-Methyluric acidPelargonic acid(1R,4S,5R)-4-ThujanolGraveoline1-MethyladenosineD-Xylono-1,5-lactoneFosinoprilSorbitolTaurine4-Amino-1-piperidinecarboxylic acidbeta-Alanyl-L-lysinePhenol sulfateCoenzyme Q92-Hydroxybenzaldehyde9alpha-Hydroxyandrosta-1,4-diene-3,17-dione1-O-Caffeoyl-beta-D-glucoseAlpha-Cryptoxanthin4-chloro-L-lysineL-ThreonineFA 18_0;OD-Alanyl-D-alanine3-Methyl-1-(2,4,6-trihydroxyphenyl)-1-butanone1-hydroxylimonen-2-oneRetronecineAdenosine phosphosulfate2-Hexaprenyl-6-methoxyphenol8-Amino-7-oxononanoic acid4-AminophenolL-Leucine6,8a-Seco-6,8a-deoxy-5-oxoavermectin 2a aglyconeDicumarolAcetohexamideFAL 8_1GlycerolLycoctonine3,4-DehydrorhodopinCatechol6alpha-GlucuronosylhyodeoxycholateDichloromethaneS-(Indolylmethylthiohydroximoyl)-L-cysteine(3Z)-Phycoerythrobilin13-L-Hydroperoxylinoleic acid6-(alpha-D-Glucosaminyl)-1D-myo-inositol1-Chloro-2-nitrobenzene6'-O-p-Coumaroyltrifolin9-Fluorenone2,3-dihydroxy-2,3-dihydrobenzoic acidCalcitriol62641-07-0Fructose 1-phosphate20,21-Diprenylterpendole CquinoloneSCHEMBL2976928Leukotriene C4cis-1,2-Dihydroxycyclohexa-3,5-diene-1-carboxylateL-Tryptophan18-Hydroxyoleic acidMonoethylhexyl phthalic acidTriethanolamineSecoisolariciresinolBaccatin_III6-HydroxyparmomomycinPinitolDopamine4-Guanidinobutanoic acidLycorineN-Acetyl-beta-alanineN-NorgramineDhurrinTestosteroneOleanolic aldehydeL-Aspartate-semialdehyde4-hydroxy-2-nonenal (4-HNE)GlycyrrhetolParthenolide(R)-demethyl-4-deoxygadusolL-ValineUracilEicosapentaenoic acidIminoaspartic acid2-Carboxyarabinitol 1-phosphateAzatyrosineTryptamineCuminaldehydeLysoPA(16_0_0_0)D-Fructuronic acid4-MethoxyflavanoneCreatine2-Hydroxybenzyl alcoholRopiniroleIsoandrocymbine2,4-DICHLOROTOLUENERacemomycin AValerateOctopineCholesterol sulfateBehenic acid3-Hydroxy-5-oxohexanoateFenbendazoleAminoundecanoic acidTricrocin2-HexenalPROPAMOCARBNeurosporene4-Acetamido-2-amino-6-nitrotoluene1-BenzylpiperazineGuanidinosuccinic acidFuranogermenoneCyanuric acid4-PyridoxolactoneFlavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucosideDiflufenicanPlastoquinone 9Maritinamine(1R,5aS,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylic acid12-oxo-PDA(-)-trans-IsopulegoneParaxanthinegamma-Glutamyl-gamma-aminobutyraldehydeK-252c1-Deoxy-D-xylulose 5-phosphateD-glycero-alpha-D-manno-heptose 1,7-bisphosphateNicotine2-aminobutyratemeso-Diaminoheptanedioate3,4-dihydroxy-2-methyl-4-farnesyl-3H-quinolin-1-ium-1-olate8-Epi-inunolide5-HydroxyisourateAscorbate radical5,10-Methylene-THF4,21-dehydrogeissoschizine(2S,2S)-Oscillol2-Oxovaleric acidPhosphoribulosylformimino-AICAR-PTaurochenodesoxycholic acidIsoglutamineCarbenicillinD-ribulose-1,5-bisphosphateCoA 10_1;OST 24_4;O4linolenate(18_3)KetospirilloxanthinD-GuloseL-Glutamic acidZerumbonebenzyl cetraxatepederinbendiocarbThreonic acid4,4-Dimethylcholesta-8,14,24-trienolTiamulinOA-6129 Etrans-2,3-EpoxysuccinateVicianinPalmitoleic acidST 29_3;OCitraconic acidDimethylglycine3-Hydroxyphenylacetic acidTerpendole E5-Amino-6-ribitylamino uracilMollicellin C(R)-3-UreidoisobutyrateGamma-glutamyl-L-putrescineIsomangiferincis-3-Hexenyl acetatePseudohypericinHydroxychlorobacteneDihydroxyacetone phosphateFurcatinPalmitic aciddelta-TocotrienolO-methylandrocymbineTetrahydrobiopterinDIBOA-GlcAdenosine 3',5'-diphosphateSaccharopine4-Hydroxycinnamic acid2-Hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoatePhylloquinol(5R,6R)-2,6-dihydroxy-5-(hydroxymethyl)cyclohex-2-en-1-onesn-glycerol 1-phosphateVitamin KTyramineAminoparathion3alpha-Hydroxy-3,5-dihydromonacolin L10-deacetyl-2-debenzoylbaccatin IIISelenocysteine3b-AllotetrahydrocortisolDeoxyadenosine8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)tetracenomycin C5,6-dihydroxy-3-methylquinolin-2(1H)-oneJadomycin B9S-HpOTrE4-HydroxymethylsalicylaldehydeD-myo-Inositol 1,4-bisphosphate3-(2-Methylthio)ethylmalateCysteinylglycineParapyruvateN-Acetyl-D-Glucosamine 6-PhosphateFormononetinDihydrosterigmatocystinGlycerophosphocholineEthylmalonate2-dehydro-D-erythronic acid5,6-dihydrouracildroperidolMedrysone2-(6-methylthio)hexylmalate5'-Phosphoribosyl-N-formylglycinamide(2'E,4'Z,8E)-Colneleic acidDeoxyamidinoproclavaminate4-KetomyxolClavulanatedihomomethionineAvermectin B1a aglyconeTulathromycinAklavin5-Oxoavermectin 2a aglyconeMycinamicin IVNorspermidineSalicylic acid4-SulfobenzoatePhosphoenolpyruvic acidbeta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-GlcpN-AcetylputrescineErgosta-5,7,22,24(28)-tetraen-3beta-olXanthinegamma-PentachlorocyclohexeneDKDIL-GlutamineUridine diphosphate glucuronic acid2-n-Propyl-4-oxopentanoic acidCoprocholic acidAsparagineFe2+epsilon-Caprolactone3-Cresotinic acidTromethamineLactyl- Brenztraubensaureubiquinone-8D-5-O-Methyl-2,3,5_4,6-pentahydroxycyclohexanoneTrandolaprilatFlavanoneNicotinic acid3-(2-hydroxyphenyl)propionate3-HydroxycyclohexanoneL-IsoleucineN-Carbamoylsarcosine7-DeoxyloganetinLeukotriene A4beta-CitraurinMaleic acid8-Hydroxyguanine(¡À)-FuraneolGluconic acidL-ArabinonateCholine phosphateAcacetin2-Furoic acid1-Pyrroline-2-carboxylic acid10-HydroxycarbazepinePentanamideEucommiolPalmitoylcarnitineExemestaneGeranyl Phosphate3-MethylindoleVersiconol acetate18-OxooleateN-Ethylammelide2-Pyrone-4,6-dicarboxylate8-Oxo-dGMP1-Methylpyrroliniumindole-3-glycol aldehyde(-)-ArctigeninPentalenolactone E4-Nitrocatechol2-ChlorophenolFormylisoglutaminePentalenolactone DL-Aspartic acid6,7-Dimethyl-8-(1-D-ribityl)lumazine17alpha,21-Dihydroxypregnenolone2-Oxoadipic acid2-Deoxycastasteronefumiquinazoline F-indoline-2,3-diolTernatin C54-Hydroxyphenylpyruvic acid(E)-3-(2,3-Dihydroxyphenyl)-2-propenoic acidAbietinol3,6-dichlorocatecholCamalexinUridine triphosphateFenoprofenFumiquinazoline C(R)-SulcatolMalvidin 3-glucosideFumiquinazoline FDethiobiotin10-Hydroxy-3-methoxy-1,3,5,7-cadinatetraen-9-oneRutinSulfiteXylitolDihydromethanophenazine2,3,4,5-Tetrahydro-2-pyridinecarboxylic acidAmygdalosidePhosphonoformyl-CMPbeta-Ethynylserinesn-3-O-(geranylgeranyl)glycerol 1-phosphategamma-TocotrienolGlycerylphosphorylethanolaminePhosphoglycolic acidN,N-dihydroxy-L-valineP-CoumaraldehydeCDPCephalosporin Cdihydro-3-hydroxy-4,4-dimethyl- 2(3H)-FuranoneUrolithin BUrolithin CDecaprenyl phosphateJuvenile hormone IIICuminyl alcoholChlorobenzeneLittorineTrans-4-hydroxyprolineOxopent-4-enoate6-Hydroxyhexanoic acidParaoxonBiotinbeta-CarbolinePentalenateL-ProlineBurseherninCysteineglutathione disulfideNeomycin3-Hydroxyanthranilic acidUrsolic acidomega-Hydroxy-beta-dihydromenaquinone-9FA 6_2;O2-AminovalienoneDicyclohexylamineQ271321345-Aminoimidazole ribonucleotideCarbamic acidTriacetic acid2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinonePsychosine sulfateButyrylcarnitineD-Arabinono-1,4-lactone3-Hydroxykynurenamine3,4-Dihydro-9H-fluorene-3,4-diol5-chlorobenzene-1,2,4-triol4-MethylaminobutanalGuanosine monophosphate3-EthylphenolOleic acidST 27_1;OGlutaric acid4-Chlorobenzoic acidThialysine ketiminebeta-Peltatin A methyl ether4-Methylaminobutyrateconiferyl acetateAdenylsuccinic acid2-Dehydro-3-deoxy-D-fuconateGentamicinc1AMoupinamideDMPPPseudouridineBenzoxazolinate5-(Hydroxymethyl)-2-methylpyrimidin-4-OLNorlaudanosolineABA-GE cpdCurcumin monoglucosideValidamine 7-phosphatejadomycin A4-HydroxybenzeneacetonitrileArgininosuccinic acid disodiumL-Formylkynurenine3-hexenalBetulinic acidalpha-D-Aldosyl beta-D-fructosideGeranylgeranyl bacteriochlorophyllide aChlorpropham5,6-DihydrothymineAlloepipregnanolone5-HydroxyconiferaldehydeDiethylphosphateIsovaleric acidSinapyl alcoholGlyceraldehyde 3-phosphate1,3-CyclohexanedioneD-FucoseGLUFOSINATEPinoresinolMethacrylyl-CoAepisteronedUDP3-MethylxanthineISOPHTHALIC ACIDChrysophanol-9-anthrone(R)-beta-Aminoisobutyric acidPyridoxamine 5'-phosphate4-OxalomesaconateBiliverdin4-Hydroxy-1-(3-pyridinyl)-1-butanone4-Hydroxymandelate2-Hydroxy-2-[2-oxo-2-[[4-[(3-aminopropyl)amino]butyl]amino]ethyl]-2-[2-oxo-2-[[4-[[3-[(3,4-dihydroxybenzoyl)amino]propyl]amino]butyl]amino]ethyl]acetic acid2-Aminoisobutyric acidHomocitric acid2-Phosphoglyceric acid2-Methylene-4-oxopentanedioic acidmethyl gibberellin A9UDP-alpha-D-galactofuranosePyrophosphateUridine2,3,6-Trihydroxypyridine1-Methoxy-4-(2-propenyl)benzeneAnilazineJuglonePhosphoribosyl formamidocarboxamide(¡À)-2-Hydroxy-2-phenylacetonitrile3-SulfinoalanineN(4)-aminopropylspermidineFluoroacetaldehydeO-Phosphohomoserine3-IndoleacetonitrileCyanidin 3-glucosideGeissoschizineGalloyl glucose3-Geranylgeranylindole; 3-(Geranylgeranyl)indoleIsoniazid4'-PhosphopantothenoylcysteineThiamineGalactitolDehydroxypaxillineL-Glutamic gamma-semialdehyde3-Hydroxyl kyneureninePhosphoroselenoic acid5-Acetamidovalerate12,13-DiHOME2-Heptyl-3-hydroxy-quinoloneButyl 4-aminobenzoateFA 18_2;O2Fumaric acidL-TyrosineAcetylcarnitineDihydroconiferyl alcohol4-HydroxycoumarinBaicaleinS-Carboxymethyl-L-cysteineUreidoglycineHypotaurineSucrose2,4-Toluenediamine2'-Deoxyguanosine 5'-monophosphateD-Tagatose 6-phosphateD-Ribulose 5-phosphate16alpha-hydroxyprogesteroneMelilotoside3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvic acidBiotin sulfoxidegamma-Glutamyl-alpha-aminobutyrateSpheroidenone4-Nitroquinoline N-oxide(R)-AmphetamineCID 440908Cannabisin E7-Cyano-7-deazaguanine10,11-Epoxy-3-geranylgeranylindole3-AminopropionaldehydeSpermidineTriethylamine4-demethyl-Indole-5,6-quinonechloric acidD-Erythro-imidazole-glycerol-phosphateAflatoxin M12-methyl-6-solanyl-1,4-benzoquinol3-Oxalomalic acid5-Methylthioribose1,3,7-trimethylurate7-hydroxy-4-isopropenyl-7-methyloxepan-2-oneST 28_2;O4DihydrovaltrateAdoMetNA 28_8;O25-epi-Lividomycin B4-Hydroxyretinoic acidSophoraflavanone G6-HydroxyflavanoneP 518Acetone cyanohydrinAnhydrorhodovibrinScopolin2,3,4,6-Tetrahydroxybenzophenone2-Hydroxy-3-carboxybenzalpyruvate4-AcetylbutyrateSuberic acidFormyl-5-hydroxykynurenamineIsovaleraldehyde5-HydroxyindoleacetaldehydePyridoxal 5'-phosphateGinsenoside Rg35'-Phosphoribosyl-N-formylglycinamidine4-NitrophenolPiperinePC(16_0_18_1(9Z))CyclohexanoneBenzimidazole8-methylthiooctanaldoximedesulfosinalbinOcthilinoneQuetiapineCefprozilAKOS006369514D-PantethineConiferinFarnesyl phosphatePyridoxineGuanidinoacetate2,4-DINITROANISOLED-2-Amino-hexano-6-lactam1,2-Dihydronaphthalene-1,2-diolPaspalinineOxethazaineNicotinamide adenine dinucleotide phosphateStachydrineN-Acetylleucine1-palmitoyl-dihydroxyacetone-phosphate(3R,5R,6S,7S,9R,11E,13R,14S)-14-[(1R)-1-hydroxyethyl]-3,5,7,9,13-pentamethyl-2,4,10-trioxo-1-oxacyclotetradec-11-en-6-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosideEDDA10,11-epoxy-3,11-dimethyl-7-ethyl-2,6-tridecadienoic acidHistidinalValeroidineGalactose 1-phosphateAstaxanthinchlorohexadienedioic acid2-Amino-3-carboxymuconic acid semialdehydeQuercetin 3-glucosyl-(1->2)-galactosyl-(1->2)-glucosideGuanosine diphosphate mannosegentiobioseMethanophenazineCycloserineNicotinamide ribotideGlycerophosphoric acidBetainePteridine diphosphateST 21_4;O2L-seryl-adenylateN-Methylhydantoin2-hydroxy-3,4-dihydro-2H-1,4-benzoxazin-3-oneSeleniumFructoselysine 6-phosphateKetopantolactoneCDP-ethanolamineCyclopentanoneGlycinolisopentenyl adenosineXanthylic acid7-Acetylintermedine4-HYDROXYTRYPTAMINEbeta-CryptoxanthinNaphthalene epoxideChloroquinol13(S)-Hydroperoxylinolenic acid3-Dehydro-2-deoxyecdysoneIsoquinolineTryptopholMethylarsonateL-LysineCapsiamideD-glucaro-1,5-lactonePhosphoserine(R)-AcetoinNalpha-MethylhistidineIsobutanal oximeDimethylbenzimidazole5-Amino-6-(5-phosphoribosylamino)uracil3-MethylmuconolactoneEugenolLimonoateDodecanoic acidUridine 5'-diphosphatePseudoephedrineisoroquefortine CSphinganinePhosphohydroxypyruvic acidPerakine2-Hydroxyoctadecanoic acidTetrahydrofolic acidkaempferol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-glucosyl-(1->2)-beta-D-glucosidethreo-b-methylaspartatePE 40_43-Carbamoyl-2-phenylpropionic acidToluene-cis-dihydrodiolValienonePremithramycin A3DiphyllinMenaquinone-9FAL 16_1Premithramycin A2SulfateIsonicotinic acidStyrene cis-glycol4,4-Diaponeurosporene7a-Hydroxy-cholestene-3-one5-methylthiopentanaldoxime2,5-Bis(hydroxymethyl)furanL-HomoserineD-XyloseDihydrofolic acid9(S)-HPODECHEMBL441356FA 8_1N-hydroxy-L-phenylalanine3-DehydroecdysoneL-Lysopine4-O-beta-D-Mannopyranosyl-D-mannopyranoseGuanosine diphosphate27-Deoxy-5b-cyprinol4-Hydroxy-2-butenoic acid gamma-lactone4alpha-hydroxymethyl-ergosta-7,24(241)-dien-3beta-ol2-Hydroxyadipic acidDL-Malic acidPodofilox2,8-QuinolinediolPhytol2-Octaprenyl-6-methoxyphenolBarbituric acidSinapinePorphobilinogen13-Desoxyterpendole IN-Glycoloylganglioside GM2(+)-GallocatechinDibenzothiophene 5-oxide3-Methyl-1-butylamine4-isopropenyl-7-methyloxepan-2-oneLevobunololtrans-p-Feruloyl-beta-D-glucopyranosideBiguanide13-DihydrocarminomycinPhaseollinProtomycinolide IVPhosphoenol-4-deoxy-3-tetrulosonateL-HistidinolGabapentinLecithinAmidinoproclavaminateD-Arabino-hexos-2-uloseCoproporphyrinogen IIIaureusidin 6-O-glucoside2,3-didehydrobutyrine3-Hexaprenyl-4-hydroxy-5-methoxybenzoic acidHyperforin3-MethoxytyramineCoumesterolBROMOBENZENE14,15-Epoxyemindole SBPhosphategeranylhydroquinone3beta-hydroxy-5-cholestenoateFADH4-HydroxymethylcatecholMesembrineNiacinamideSalsolinolDiaminopimelic acidPropioinSerotoninGalactinol(Z)-[(4-hydroxyphenyl)acetaldehyde oxime]SanguinarineCYCLOHEXANECARBOXYLIC ACID, 4-HYDROXY-3-OXO- (9CI)N-acetylneuraminateAbietatrienePretyrosineprecorrin-1Bromobenzene-2,3-oxideSequoyitolChelirubinePhycocyanobilin3alpha,7alpha-Dihydroxycoprostanic acidD-4'-PhosphopantothenateNadide1-Piperideine-2-carboxylic acidD-glycero-D-manno-Heptose 1-phosphate4-Carboxy-4-hydroxy-2-oxoadipateVitexin 6'-O-malonyl 2'-O-xylosideAminocaproic acidCortolPrimeverose4-FormamidoantipyrineST 19_4;O321,22-Diprenylpaxilline2,4-DichlorophenolIndoleacrylic acidPropranololMercuric cationEthylmethylacetic acidNovapikromycin3-Fluorocatechol10'-Apo-beta-carotenalPurpurinGlyceollin IIIChlorophyllide bBenzoyl-CoA3-Amino-2-azepanonecis-Zeatin O-glucosideImidazoloneCoumarinfluacrypyrimAridanin7,8-diaminopelargonateMyristic acidLevanArabitol5-Sulfosalicylic acidST 29_2;O2-PhenylethanolSuccinic acidFA 6_3;O37,8-DihydromethanopterinHypoxanthineBergaptolGigantine2,4-DinitrophenolLinamarinL-ArginineFO 2546M2,6-DiethylanilineNevirapineFUBERIDAZOLEUreidoperacrylic acid6-HydroxyprotopineRishitinRhizocticin ASulcatoneN-IsopropylammelideNnal-N-oxideResveratrolN6,N6,N6-Trimethyl-L-lysineGalactitol 1-phosphateFA 18_1;O2,5-DichlorophenolOphthalmic acidAflatremMacarpineN-acetylglucosaminylasparagine1-Pyrroline-4-hydroxy-2-carboxylateAdenineD-Pyroglutamate3-amino-3-(4-hydroxyphenyl)propanoic acidLeprotin6-Deoxy-5-ketofructose 1-phosphate2-Hydroxy-3-(1H-imidazol-5-yl)propanoic acidNaloxone(25R)-26-hydroxycholest-4-en-3-onefusicocca-2,10(14)-diene1-MethoxyphenanthreneInosineL-SerinePurineN¦Á-Acetyl-L-lysinecorynanthealHomocysteine4-methyl-3-oxoadipate-enol-lactoneBryophyllin ALumichromeACMC-20dgc9O-acetylhomoserine6-O-methyl-N-deacetylisoipecoside aglycon2,5-dichlorohydroquinoneCholic acidArachidonic acid(3S)-3-hydroxycyclocitral6-ChlorohydroxyquinoltrihomomethionineLactose 6-phosphateN-hydroxyl-tryptamineMesoxalic acidYateinN-CyclopropylammelideUreidosuccinic acid1,2-CyclohexanedioneIsovaleryl-CoAVitamin A2 aldehydeL-Dopaquinone3-Thiomorpholinecarboxylic acidDihydrostreptomycinD-4-Hydroxy-2-oxoglutarateRhamnetinTerephthalate-1,2-cis-dihydrodiol4-hydroxymandelic acidIsoglutamateStigmatellin Yecdysoneaurachin B epoxide6-Aminopenicillanic acidImperialinCucurbitacin Dgamma-GlutamylcysteineDimethylpropiothetinSebacic acidN-acetylglutamateL-Methionine2-Formylaminobenzaldehyde(2R)-2-hydroxy-3-(1H-indol-3-yl)propanoic acidArginine, N2-benzoylN-hydroxy-L-isoleucineTheophyllineUDP-N-acetylmuramoyl-L-alanineSAICARMedermycinL-4-Hydroxyglutamate semialdehyde(¡À)-2-MethylbutanalLeucyl-leucineTreosulfanFA 18_0;O25-Amino-2-oxopentanoic acidOxytetracycline17a-HydroxypregnenoloneAcrylamideDiisobutyl phthalate2-oxo-5-Methylthiopentanoic acidTrithionatecis-zeatin ribosideApigeninThyroxinePyroglutamic acidCytidine triphosphate2-NitrophenolPyridoxaminePicrocrocinGlucosamine 6-phosphate9-methylthiononanaldoximeChymosin preparation, escherichia coli k-128-oxogeranialL-pentahomomethionineBotrydialFurylfuramidecis-AcetylacrylateDodecanedioic acidgermacradienolhexahomomethionineMethyl sulfateDeoxyguanosineGingerolFA 12_3;O2N-Methyl-4-dimethylallyltryptophanCathinePE(16_0_18_1(9Z))(2E)-Decenoyl-ACPLipoamideSildenafilDihydromacarpineHomoserine, O-succinyl-L-2-Amino-6-oxopimelate2-hydroxypropyl-CoMPhosphodimethylethanolamineDemethylphylloquinoneCytidine monophosphateDibutyl phthalateThymidineTranexamic Acid7-ChlorodehydrotryptophanChalcone5-Acetylamino-6-formylamino-3-methyluracilCostunolideOrotic acidIndole-3-acetamideNaproxen3-(all-trans-octaprenyl)benzene-1,2-diolditrans,pentacis-Octaprenyl diphosphateChrysosplenetinDihydromenaquinone-9ClavaminateMevaldateMagnolineBufalin1-Pyrroline-5-carboxylic acidHistamine2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate4-Oxo-1-(3-pyridyl)-1-butanoneMycocyclosin24,25-Dihydroxyvitamin DImidazole pyruvateO-Phosphothreonine2-oxostearic acidN-Methyl-D-aspartic acidProstaglandin F3aFAMPL-Fucono-1,5-lactone2-Methylacetoacetyl-CoA(3-Phenoxyphenyl)methanol17a-Ethynylestradiol4-HydroxysphinganineL-2-Amino-3-oxobutanoic acidLeucocyanidinOxazepamRibose 1,5-bisphosphateTaurodeoxycholic acidAzelaic acidST 19_2;O3D-Tagatose 1,6-bisphosphatePQQH2Oxidized Renilla luciferin2-Aminobenzoic acidGentisyl alcoholChrysophanol(Z)-2-methyl-peroxyaminoacrylateDiethyltoluamideEpinephrine2,4-Diaminopentanoate2-Amino-5-oxohexanoate8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)tetracenomycin C2-methyl-6-geranylgeranyl-1,4-benzoquinolBergaptenFA 18_14-Aminobiphenyl4a-Hydroxytetrahydrobiopterin2-Hydroxy-2-ethylsuccinic acid3-Amino-5-hydroxybenzoic acidjusticidinsPsoralenDeoxycytidineLysoSM(d18_1)Norvaline1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineBiopterinDaidzeinfalseMetabolomic Analysis of Candida albicans under Metal-based anti-fungal strategy<p>Based on a unique pathogen iron interplay mechanism, this work establishes a new therapeutic paradigm targeting iron homeostasis at the host-pathogen interface via sequential metabolic priming, offering a broadly applicable strategy to reprogram resource asymmetry and combat fungal infection.</p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