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identification was achieved by matching the retention time, accurate molecular weight, and MS/MS fragmentation patterns of detected metabolites with those in standard databases, combined with the mass spectrometric parameters and chromatographic separation characteristics.</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phase<p>For polar metabolites detection, chromatographic analysis was performed on a Vanquish ultra-high performance liquid chromatography system (Thermo Fisher Scientific). Separation was achieved using a reverse phase Waters ACQUITY UPLC BEH C18 column (2.1mm × 50mm, 1.7μm) — a typical reverse phase column suitable for polar metabolites separation, with mobile phase A (25mmol/L ammonium acetate and 25mmol/L ammonia aqueous solution) and mobile phase B (acetonitrile). The sample plate temperature was maintained at 4 ℃, and the injection volume was 2 μL.</p>A diet-microbiome-host-drug efficacy axis in chronic alcohol-increased anaesthetic use.Henggong panYunnan Agricultural Universityfaecesmass spectrometry assay<p>Fecal samples were accurately weighed (50 mg per sample), homogenized with 500 μL pre-cooled extraction solvent (methanol:acetonitrile:water = 2:2:1, v/v/v) containing internal standard, vortexed vigorously for 3 min, and sonicated on ice for 15 min to fully release polar metabolites. After incubation at -20 °C for 30 min to precipitate proteins, the samples were centrifuged at 12,000 × g and 4 °C for 15 min. The supernatants were collected and filtered through 0.22 μm organic phase filters, and the filtrates were used for ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) analysis (combined chromatographic and mass spectrometric detection).</p>Mus musculusHomo sapienshttps://www.ebi.ac.uk/metabolights/MTBLS13761Hejiang Zhou. Yunnan Agricultural University. Yunnan Agricultural University, No. 452 Fengyuan Road, Yunnan 650201, China. zhouhej@126.com.<p>Raw mass spectrometric data were processed using Xcalibur software and metabolomic analysis tools for peak extraction, alignment, deconvolution and normalization. Metabolites with more than 50% missing values were removed, and multivariate and univariate statistical analyses were performed to screen differential metabolites.</p>Treatment17677243518@163.com<p>Fecal samples were collected from non-drinkers and drinkers, immediately snap-frozen in liquid nitrogen after collection to avoid metabolite degradation, and then stored at -80 °C until subsequent pretreatment and detection.</p>Metabolomicsalcohol abuseuntargeted metabolitesmicrobealcohol abuseuntargeted metabolitesmicrobe<p>Mass spectrometric detection was conducted on an Orbitrap Exploris 120 mass spectrometer (Thermo Fisher Scientific) controlled by Xcalibur software (version 4.4), equipped with an electrospray ionization (ESI) source, and operated in both positive and negative ion modes. Key parameters included sheath gas flow rate 50 Arb, auxiliary gas flow rate 15 Arb, capillary temperature 320 ℃, full ms resolution 60,000, MS/MS resolution 15,000, collision energy SNCE 20/30/40, and spray voltage 3.8 kV (positive) or -3.4 kV (negative).</p>S-AdenosylmethioninamineCisapride9,10-DHOMEp-Mentha-1,3,5,8-tetraeneCorticosteroneProstaglandin G2Salmeterol4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acidAdefovir DipivoxilAustinDiazoxideAlantolactoneImidazolelactic acidgamma-Aminobutyric acidMesoridazineN-a-AcetylcitrullineKinetinKetoleucineL-Histidine2-Keto-6-acetamidocaproateReserpineTacrineTimololDicaffeoylquinic acidLutein3-Methyl-3-hydroxypentanedioateCitrullinePropoxyphene2,6-DimethoxyphenolN-Methylethanolaminium phosphateDihydroergotamine4-HydroxybenzaldehydeTerazosinNaringenin chalconeIpratropiumBADGEBetanin9-cis-Retinoic acidMarindininPilocarpineN2-Succinyl-L-ornithine3,4-Dihydroxymandelic acid10,11-DihydroxycarbamazepineIsobornyl propionateJasmoneIsoelemicinN6-Acetyl-L-lysineHordenineMaltitolMolindone6beta-HydroxytestosteroneTaurohyocholate5-Hydroxymethyl-2-furaldehyde13S-hydroxyoctadecadienoic acidChloroxineLacto-N-biose I15-Acetyl-4-deoxynivalenolEpsilon-(gamma-Glutamyl)-lysinePregnanediolGlutathioneL-Theanine12,13-DHOME7-DehydrodesmosterolStreptomycinTriethyl citrateCapsanthin5-HydroxylysineMaltopentaoseN2-Succinyl-L-glutamic acid 5-semialdehydeCaffeic acidAllopregnanoloneIsodesmosineIsophoroneMepivacainePerillyl alcoholOleamideGravelliferoneRitodrineLidocaineLevetiracetamYohimbine7,7',8,8'-TetrahydrolycopeneOmeprazole sulfoneErucic acidXanthurenic acidIndoleacetaldehydealpha-MangostinMetalaxylDeoxyuridine-5'-triphosphatePhenylephrineAcetylglycineKanamycinNeosaxitoxinProcyclidineCanthaxanthintrans-Isoasarone2-Biphenylol22b-HydroxycholesterolPhthalic acid4-Acetamido-2-aminobutanoic acidCarmustineAminoadipic acidMupirocin7a,12a-Dihydroxy-5b-cholestan-3-oneIsorhamnetin3alpha,11beta-Dihydroxy-5alpha-androstane-17-oneElemicin13,14-Dihydro-15-keto-PGE2Lithocholic acid glycine conjugateDigitoxinAcetophenazine(S)-2-Propylpiperidine1,3-BenzenediolOrnithineAndrostenedioneFluvoxamineAmcinonide3-MethyladenineSmilageninIndolep-MethoxycinnamaldehydeProtochlorophyllideLovastatinDextromethorphanProstaglandin A1NorpropoxypheneBeta-tocopherolIsocitric acidMethyl methanethiosulfonateIndolin-2-oneL-CarnitineVenlafaxineAvocadene 2-acetate2',2'-Difluorodeoxyuridine13-OxoODECyclopentolateMethazolamideDiethylpropionPiperonalAdenosineNitrendipineDihydroactinidiolidedIMP9-OxoODEBeta-D-Fructose 6-phosphate[6]-DehydrogingerdioneDrospirenoneMexiletineProstaglandin B23-O-AcetylepisamarcandinGuanidoacetic acid2-Hydroxycinnamic acid2-Methyl-6-phytylhydroquinoneLinoleic acidTacrolimusCampesterolAvenasterolDibucaineMethyleugenolSorbose 1-phosphateL-PhosphoarginineTangeretinIsopimpinellinBetonicinebeta-Selinene5a-TetrahydrocortisolStearidonic acid(S,E)-ZearalenoneClomipramineMorphinoneOleanolic acidCephapirin4-(Glutamylamino) butanoateEcgonineVaccenic acidProguanilSphingosine3-DehydrosphinganineChlorhexidineTetrahydrocortisone3-EpidemissidineTelmisartanL-IditolLuteolin 7-galactosideDehydroepiandrosterone sulfate2-Isopropyl-3-oxosuccinateBuprenorphineAcetaminophen5-DehydroavenasterolFlucytosineCyclobenzaprineMelibiitolN(omega)-Hydroxyargininealpha-SpinasterolGeranyl acetateTrehaloseClindamycinProcainamideUmbelliferoneGuanineMeperidine1-MethylnicotinamideTropateEpinastineEriodictyolSelegiline24-MethylenecholesterolDihydrooroxylinFlunisolideProtoporphyrinogen IX3-Acetyl-2,5-dimethylfuranRiboflavin reduced1,2,3,4-Tetrahydro-2-methyl-b-carboline3 alpha,7 alpha,26-Trihydroxy-5beta-cholestaneGlycylleucine7-Methylguanine6-Pentyl-2H-pyran-2-oneDoxapramOleoyl EthanolamideBilobalide APargylineAtrazineProcarbazineQuinestrol3-Oxovalproic acidRetinyl palmitateLevonorgestrel7a-HydroxycholesterolGlycocholic acidPipecolic acidRanolazine5-Methyltetrahydrofolic acidHygromycin BIbuprofenMirtazapine7-DehydrocholesterolMethotrimeprazineStearic acidGlutethimidebeta-Alanyl-L-arginine6-Hydroxynicotinic acidAdrenosteroneL-2,4-diaminobutyric acidOxyacanthineTerbinafineAnandamideCorymbosideDyphyllineGeranic acidColchicine2',5,6-TrimethoxyflavoneEcgonine methyl esterProstaglandin I2Cafestol1,5-AnhydrosorbitolVardenafilHaloperidolPropylthiouracilDiclofenacThyrotropin releasing hormone5,6,7,8-TetrahydromethanopterinPhenylethyl primeverosidePiperolein BFluoxymesterone(S)-Abscisic acid3,5-Diiodothyronine5-PhosphoribosylamineMethyl linoleateButyryl-L-carnitineCarbimazoleDobutamineBiocytin1-MethyladenosineTamsulosin3-Keto-4-methylzymosterolMaltolFosinoprilSorbitolbeta-Alanyl-L-lysine15-Keto-prostaglandin F2aCoenzyme Q21-MethylhistamineHesperetin 7-neohesperidosideCoenzyme Q9O-PhosphoethanolamineNaltrexoneGeranylacetoneLithocholic acidPirbuterolAlpha-dimorphecolic acidL-Threonine4a-MethylzymosterolAgmatineMyristoleic acidL-LeucineTrigonellineNomega-AcetylhistamineMedicocarpinAcetohexamide20a,22b-DihydroxycholesterolPrednisoneRetinoyl b-glucuronideLeukotriene E4Cetirizine1-palmitoylglycerophosphocholineFonsecinDanazolPentoxifyllineMonoethylglycinexylidideUbiquinone-1DL-HomocystinedTMP13-L-Hydroperoxylinoleic acidBenzatropineLoperamideUndecanoic acidCalcitriolEthyl icosapentatePyrrole-2-carboxylic acidLeukotriene D415-KETEAlpha-CaroteneSecoisolariciresinol 9,9'-diglucosideAlternariolMulberrinQuinaldic acidSe-MethylselenocysteineL-TryptophanD-Phenyllactic acidTriethanolamine4-Isopropylbenzaldehyde2-Keto-glutaramic acidN-Acetyl-a-neuraminic acidCyclizineAmygdalinPulegoneBrevianamide BDopamineOxoamide4-Guanidinobutanoic acidCholesterolLatanoprostCholestenoneDhurrinPsoralidinSoyasapogenol B1H-Indole-3-acetamideL-ValineDomoic acidIminoaspartic acidVidarabineBenzofenapIodotyrosineQuinaprilCholest-5-eneChlorprothixeneCarnosic acidL-Kynurenine9-cis-RetinalCreatineTrimeprazineIDP3-phenoxybenzoic acidAzacitidineLauric aldehydeCytosineRisperidoneRetapamulinSteviobiosideL-CystineBeta-D-Glucose 6-phosphateCaryophyllene alpha-oxide3a,7a-Dihydroxy-5b-cholestaneTrimipraminePantetheine 4'-phosphateN-Acetyl-5-aminosalicylic acidN-Acetyl-beta-glucosaminylamineAcetylvalerenolic acidCarvedilolBrassinolideNicotineSelenomethionine1,4-Dimethyl-7-ethylazulene5,10-Methylene-THFDesmosterolEuphol21-DeoxycortisolLomefloxacinRescinnamineHomovanillic acid1,1-DimethylbiguanideDisopyramideNicotinic acid mononucleotideBepridilQuinolinic acidDiacetoxyscirpenolIndinavirHarmalineL-Glutamic acidp-OctopamineZerumboneDiphenhydramine5-KETEdAMP2-HydroxyphenethylamineAllocystathionineL-3-HydroxykynurenineCinchonidine1-Oleoyl Lysophosphatidic Acid (sodium salt)Amobarbital(R)-Hispaglabridin BSulfolithocholylglycineDimethylglycineTripelennamineBeta-LeucineL-Histidine trimethylbetaine2-PentylfuranN-Acetyl-L-phenylalanineCE(5_0)DarunavirSumatriptantrans-Zeatin-7-beta-D-glucosideDihydroxyacetone phosphateD-Maltose7-MethyladenineChitobiose4a-Carbinolamine tetrahydrobiopterinPhosphonoacetateSaccharopine2-Hydroxy-3-(4-hydroxyphenyl)propanoic acidPhylloquinolTyramineGranisetron[6]-ShogaolMitomycinN-Formyl-L-methionine12-Hydroxydodecanoic acidN-Acetyl-DL-methionine5,6-DHETPergolideProcyanidin B2BrompheniramineDihydrojasmoneGatifloxacinCiliatine5a-Cholest-8-en-3b-olN4-AcetylcytidineOkadaic acid(R)C(S)S-AlliinDihydroxyfumaric acidCysteinylglycineN-Acetyl-D-Glucosamine 6-PhosphateGlycerophosphocholineHesperidinEdrophoniumErgothioneine1-Aminocyclopropanecarboxylic acidMedrysoneAmikacinVareniclineTrilostane5'-Phosphoribosyl-N-formylglycinamideCefdinirPeonidin-3-glucoside2-Methylbutyryl-CoANizatidineIndoleacetic acidDiethylcarbamazineLuteolinHydroxyphenyllactic acidGlaucarubinSalicylic acidN-AcetylhistidineLevulinic acidOrciprenaline4-Hydroxyphenylacetylglutamic acidAfzelechin2-Keto-6-aminocaproate(S)-ReticulineCarteololMannitol 1-phosphateXanthinetrans-Aconitate5-Methoxysalicylic acid4a-Carboxy-4b-methyl-5a-cholesta-8,24-dien-3b-olDecanoylcarnitineL-GlutamineN-(L-Arginino)succinatexi-5-Hexyldihydro-2(3H)-furanoneepsilon-CaprolactoneBlasticidin SMethaqualoneCapsidiolMonocrotalineDelphinidin 3-rutinosideNicotinic acidN-AcetylmuramateAcetylcysteine5-HydroxymethyluracilAldosteroneL-IsoleucineGentian VioletSesaminall-trans-Retinoic acidNandroloneAsymmetric dimethylargininePhenylpropionylglycine5alpha-DihydrodeoxycorticosteroneDulcin7-MethylxanthineBetulinIndoxyl sulfateDocetaxel10-HydroxycarbazepinePhosphorylcholineExemestaneS-AdenosylhomocysteinePhenobarbitalIrbesartanAtomoxetineL-Aspartic acidProcaineSM(d18_1_16_0)ZingibereneD-ArabitolProtoporphyrin IXRifapentine2'-DeoxyadenosineSarsasapogeninDihydrocholesterol17alpha,21-Dihydroxypregnenolone3,3',4'5-TetrahydroxystilbeneL-TarginineFenamiphosMenthyl pyrrolidone carboxylate2-Deoxycastasterone3,4-DihydroxyphenylpropanoateIsolithocholic acidRolitetracyclineThromboxane B2CitalopramTrehalose 6-phosphate12-Keto-leukotriene B4DihydrothymineCephalexinMifepristoneEpsilon-caprolactamp-Aminobenzoic acidBaicalinDi(2-ethylhexyl) adipateFenoprofenAtazanavir(R)-SulcatolN-Acetyl-b-glucosaminylamineCimetidineDethiobiotinRutinIndole-3-carboxylic acidIrinotecan(R)-ar-TurmeroneAlfentanilEstroneLevorphanolSulfathiazoleSinapateOxyphencycliminePropiomazineMechlorethamineLipoxin B4Phosphoglycolic acidRiboflavinRamiprilCephalosporin CAspartamebeta-LactoseConiferyl alcoholAminoglutethimideN1,N12-DiacetylspermineQuinolineMeropenemNicotinate D-ribonucleoside2-Methylbenzoic acidPholcodineParaoxonOxoglutaric acidBiotinGMPHydrochlorothiazideL-ProlineDelphinHydromorphone1-Methylxanthine(S)-2,3-EpoxysqualeneAmpicillinSorbitan stearateAmlodipineN1-AcetylspermidineUrsolic acidDeoxycorticosteroneAlpha-Linolenoyl ethanolamideMethylphenidate3a,7a-Dihydroxy-5b-cholestan-26-al5-Hydroxyindoleacetic acidCarbofuran1-HexadecanolHydroxykynurenineAucubinalpha-TocopherolButyrylcarnitinecis-4-Hydroxy-D-prolineL-AsparagineTetrahydrodipicolinateZonisamide2-MethoxyestroneOleic acidSclareolTriazolamStearoylethanolamideDicyclominePropafenoneAflatoxin G2TetrahydrocannabinolEtiocholanoloneN-Acetylglutamic acidFluoxetineMoupinamideAnastrozoleMiglitolUridine diphosphate-N-acetylglucosamineTofisopamGinkgolide BRotenone3'-SialyllactoseGlyburideMyo-inositol hexakisphosphateTazaroteneLinatineMethylselenopyruvatePenbutololDihydrocapsaicinBetulinic acidMaduramicinImidaclopridCiprofloxacinMepyramineVitamin D3PraziquantelTG(16_0_16_0_16_0)GuanosineRibothymidineSinapyl alcohol5-HydroxyindoleacetylglycineTrimethoprimMoxifloxacinbeta-D-GlucosamineEfavirenzADPChlorpromazineKetoprofen17alpha-Hydroxyprogesterone1,7-bis(4-hydroxyphenyl)-5-methoxyheptan-3-oneMethylisoeugenol3-Carbamoyl-2-phenylpropionaldehydeBiliverdinCoproporphyrin IIfosfamideN,N-DimethylsphingosineApioleClozapine N-oxideCyclic AMPHomocitric acidNitrofentrans-trans-Muconic acidAprindineNicotinurateFenvalerateSulfamethazineCis-zeatinDichlorvos9S-hydroxy-11,15-dioxo-5Z,13E-prostadienoic acidEnterodiolSulfaphenazolePindololNilotinibStreptozocinBenzoyl phosphateStigmasterolBupivacaine3-Hydroxymethylglutaric acid6-Keto-prostaglandin F1a3-IndoleacetonitrileDecanalObacunone3-NitrotyrosineFasciculic acid CFasciculic acid BThiamineN-MethyltryptamineMultinoside AL-Glutamic gamma-semialdehyde5-AcetamidovalerateL-DopaBaicaleinMidazolamClarithromycinSucrose8,9-EETTrihexyphenidyl(R)-HeraclenolDL-HexanoylcarnitineMetoclopramideGuanabenzDiphenoxylateSpermidineCortexoloneTriethylamineDimethyl trisulfide2-Naphthylamine2-Hexaprenyl-6-methoxy-1,4-benzoquinoneTaurocholic acidLopinavir4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanoneCMP8-MethoxykynurenateNorfloxacinPropionylcarnitineAlbendazole sulfone11-Dehydro-thromboxane B2Amentoflavone4-Hydroxyestradiol4-Nitrophenyl phosphateMaprotilineThiotepaEntacaponePerindoprilSufentanilIndolebutyric acidMetanephrineN(6)-MethyllysineTolmetinIvacaftor4-AcetylbutyratePhosphoribosylformylglycineamidine5-MethylcytidineOxaprozin5-Hydroxyindoleacetaldehyde3-MethoxyanthranilateN-Benzoylanthranilic acidAstemizole5'-MethylthioadenosineOxacillinOctadecanamidePiperine8,11,14-Eicosatrienoic acidRivastigminem-CresolQuetiapineCefprozilD-PantethineMethyl dodecanoateMyricetin 3-galactosideMethyl hexadecanoic acidPyridoxineOrphenadrine5-MethoxydimethyltryptamineRifabutinFormiminoglutamic acid5-Hydroxypentanoic acidQuercitrin2'-Deoxymugineic acidParomomycinThiabendazole10-FormyldihydrofolateFurohyperforin4-Acetyl-6-tert-butyl-1,1-dimethylindaneTubocurarineAstaxanthinTiglic acidCortisolEpisterolN-MethylhydantoinAminopterinMitoxantrone3a-Hydroxy-5b-pregnane-20-oneClionasterolDelta-HexanolactoneNortriptylineTriparanol4-Acetamidobutanoic acidHesperetinPterinXanthylic acidFluconazole6-AcetylmorphineDexbrompheniramineGinsenoside Rh3Oxymetazoline4-PhenylbutyrateDehydrovomifoliolMycophenolategamma-GlutamylalanineAcetaminophen glucuronideIsoquinolineAtorvastatinMesobilirubinogenPyridostigmineZymosterol intermediate 21-Methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amineVecuroniumEthylmorphineKetorolacDimethylbenzimidazole5,7-DimethoxyflavoneDodecanoic acidEugenolGenipinNorethindronePseudoephedrinePhytolaccasaponin GLicoricidinEndomorphin-2Sphinganine6-Hexyltetrahydro-2H-pyran-2-one2-Hydroxyestrone7,8-DihydroneopterinTetrahydrofolic acidCadaverineMetoprololTraumatic AcidDelta-TocopherolNootkatoneOleoylethanolamide(S)-Pinocembrin4,5-Dihydroorotic acidHydroxyzineOxybutyninProgesteroneDelta7-AvenasterolFlunitrazepamNeoxanthin(R)-HigenamineD-FructoseGenistinXanthohumolAllantoinAngiotensin IIIEphedrine2-Methoxy-17beta-estradiolRiluzoleImipramineDihydrofolic acid1,11-Undecanedicarboxylic acidEnalaprilSuprofen27-Deoxy-5b-cyprinolKynurenic acidSparfloxacinAjmalineXylometazolinegamma-Glutamyl-beta-aminopropiononitrileLisinoprilThiamine monophosphateTranylcyprominePalmitoylethanolamideAnabasineEsmololMuramic acidBarbituric acidSinapinePentamidinePorphobilinogenT2 TriolNalbuphineTyrosol5-Formiminotetrahydrofolic acidEstazolamVignafuranNeopineDIHYDROJASMONIC ACID, METHYL ESTERL-HistidinolCelastrolPhenelzineNevskinCarnosine5alpha-CholestaneMetaraminolDeferoxamineHyperforinNeostigmineLincomycinSpironolactoneTatridin B3'-(1''-(3-Methylbutanoyl))-angeloyl vaginidiol6-ParadolTaraxerolDihydromethysticinNiacinamide5-AminopentanalDiaminopimelic acidSerotoninDeoxyuridinePrimidoneGlycineamideribotideHydrocinchonineSanguinarineZeranol5-Dehydroepisterol1-Benzyl-1,2,3,4-tetrahydroisoquinoline10-FormyltetrahydrofolatePQQPentaporphyrin INalpha-Acetyl-L-arginineN-Acetylmannosamine5a-Pregnane-3,20-dioneRacemethionine4-Hydroxy-3-methoxybenzenemethanol5,6-Dihydro-5-fluorouracil1,7-Dimethyluric acidD-4'-PhosphopantothenateIndolelactic acidTrifluoperazineN-AcetylserotoninHarmine11Z-Eicosenoic acido-Xylene2,3-Diaminopropionic acidPhytosphingosineOleoylcarnitineFormoterolPropranololpsi-PelletierineClofibrateLevamisoleErgocalciferolLenticinNebularine17a-Estradiol5-(Methylthio)-2,3-dioxopentyl phosphateQuercetin 4'-glucosideCyclophosphamideHydroxychloroquineSilibinin2-Phenylethanolbeta-SitostenonePelletierineL-ArginineBetaxololPermethrinNevirapine2-Hydroxyglutarate7,8-DihydroyangoninAcetazolamide2-ArachidonoylglycerolDocosahexaenoyl EthanolamideCitreoviridinGalactosylsphingosineN,N-DimethylanilineL-CysteineN6,N6,N6-Trimethyl-L-lysineN-Succinyl-L,L-2,6-diaminopimelate2-Hydroxybutyric acid(S)-N-MethylcoclaurineDiethylphosphoric acidEnoxacinHomocitrullineProchlorperazineGamma-TocotrienolCortisoneEnalaprilat2-trans,6-trans-FarnesalCurloneDidanosineThioproperazine2-PyrrolidinoneMethylimidazoleacetic acidFinasteride5,7-dihydroxy-2-phenyl-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-8-(3,4,5-trihydroxyoxan-2-yl)-4H-chromen-4-onePrimaquinePromethazineCE(16_0)OuabainMethadoneMethylprednisolonePC(20_5(5Z,8Z,11Z,14Z,17Z)_20_5(5Z,8Z,11Z,14Z,17Z))Protocatechuic acidCarnosolBenzoylecgonineSubaphylline2-(Methylamino)benzoic acidEllagic acidAnserineUreidosuccinic acidIsovaleryl-CoAN-Oleoyl phenylalanineMethotrexateCaffeinePropionylglycineMono-benzyl phthalateTetrahydropteridineAllocholic acid(S)-3-Hydroxy-N-methylcoclaurineGeniposidic acidN,N-Diethylbenzeneacetamide4-Hydroxybenzoic acidLanosterinQueuineGamma-Linolenic acid6-Aminopenicillanic acidVanillylmandelic acidArbutinCucurbitacin DVanylglycolCarbamazepineCucurbitacin BD-XylitolSebacic acidL-MethionineN-MethyltyramineThioridazineDihydrouracil5-HydroxypyrazinamideMG(18_2(9Z,12Z)_0_0_0_0)[rac]beta-SitosterolMethyldopa24,25-DihydrolanosterolTheophyllineEthynodiol DiacetateNalidixic AcidOrotidylic acidVomitoxin5-(2-Hydroxyethyl)-4-methylthiazoleN-AcetylornithineN-methyl-L-glutamic AcidNeocnidilidePicolinic acidAspartylglycosaminePrephenateTridemorphMannitolN7-MethylguanosineThyroxinePyridoxamineChavicolGlucosamine 6-phosphateTIAPRIDE8,9-DiHETrE4-HydroxycinnamoylagmatineErgosterol5alpha-Cholestanone3,4-MethylenedioxyamphetamineAndrosteroneProtriptylinePC(18_3(6Z,9Z,12Z)_18_3(6Z,9Z,12Z))DL-DopaMefenamic acidAzatadineAcetylcholineSildenafilLysoPE(14_1(9Z)_0_0)xi-Tetrahydro-6-propyl-2H-pyran-2-oneDemethylphylloquinoneKyotorphinGeranylgeranyl-PP2-Ketohexanoic acidLabetalolTranexamic AcidDiphenylamine4-(2-Aminophenyl)-2,4-dioxobutanoic acidUrsodeoxycholic acidDiosmetinPentyl octanoateTramadolTryptophanolCysteine-S-sulfate3-Phosphoglyceric acidI-UrobilinPyrimethamineBenzaldehydeFenoterolMandelic acidVitamin K1Lathosterol20-HydroxyecdysoneMethyl jasmonateHistamineKojibioseNimodipineFenthion3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-alDyclonineEthyl oleateN-Alpha-acetyllysineProstaglandin F3aMitragynineNormetanephrineRaffinose4-Hydroxy-3-(3-methyl-2-butenyl)acetophenone2,3-ButanediolMedroxyprogesteroneL-2-Hydroxyglutaric acidN-LignoceroylsphingosineProstaglandin F2bImidazolepropionic acidProstaglandin F2a11b-Hydroxyandrost-4-ene-3,17-dione16(R)-HETE(R)-SalsolinolEpinephrineChlorpyrifosMefloquineAndrosta-1,4-diene-3,17-dione2',4'-DihydroxyacetophenoneTerfenadineTolterodine3'-AMPAcebutololCelecoxibClozapineDeoxycholic acidN1-AcetylspermineChlorpheniramineCarbamoyl phosphate12-Keto-tetrahydro-leukotriene B4LubiprostoneBiopterinfalseList of metabolites of human feces of control and alcohol-exposed groups<p>To explore the diet-microbiome-host-drug efficacy axis in chronic alcohol-increased anaesthetic use. Fecal metabolites were comprehensively extracted, detected and analyzed to identify differential metabolic profiles induced by chronic alcohol consumption, providing a basis for revealing the correlation between fecal metabolic changes and increased anaesthetic demand.</p>2026-01-252026-01-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