MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13814/m_MTBLS13814_LC-MS_negative_reverse-phase_metabolite_profiling_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13814/m_MTBLS13814_LC-MS_positive_reverse-phase_metabolite_profiling_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13814/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13814/a_MTBLS13814_LC-MS_positive_reverse-phase_metabolite_profiling.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13814/s_MTBLS13814.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13814/a_MTBLS13814_LC-MS_negative_reverse-phase_metabolite_profiling.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13814<p>These metabolites were annotated using the KEGG database</p><p>(https://www.genome.jp/kegg/pathway.html), HMDB database (https://hmdb.ca/</p><p>metabolites) and LIPIDMaps database (http://www.lipidmaps.org/).&nbsp;</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phase<p>UHPLC-MS/MS analyses were performed using a Vanquish UHPLC system</p><p>(ThermoFisher, Germany) coupled with an Orbitrap Q ExactiveTMHF-X mass spectrometer (Thermo Fisher,</p><p>Germany) in Novogene Co., Ltd. (Beijing, China). Samples were injected onto a</p><p>Hypersil Goldcolumn (100×2.1 mm, 1.9μm) using a 12-min linear gradient at a flow</p><p>rate of 0.2 mL/min. The eluents for the positive and negative polarity modes were</p><p>eluent A (0.1% FA in Water) and eluent B (Methanol). The solvent gradient was set</p><p>as follows: 2% B, 1.5 min; 2-85% B, 3 min; 85-100% B, 10 min; 100-2% B, 10.1 min; </p><p>2% B, 12 min.</p>Bupleurum chinense DC polysaccharides ameliorate DSS-induced ulcerative colitis by regulating gut microbiota and tryptophan metabolism via NF-κB pathway.Jilin UniversityLei LvCecal contentmass spectrometry assay<p>Tissues (100 mg) were individually grounded with liquid nitrogen and the</p><p>homogenate was resuspended with prechilled 80% methanol by well vortex. The</p><p>samples were incubated on ice for 5 min and then were centrifuged at 15,000 g, 4°C</p><p>for 20 min. Some of supernatant was diluted to final concentration containing 53%</p><p>methanol by LC-MS grade water.The samples were subsequently transferred to a</p><p>fresh Eppendorf tube and thenwere centrifuged at 15000 g, 4°C for 20 min. Finally,</p><p>the supernatant was injected into the LC-MS/MS system analysis</p>Mus musculus<p>The raw data files generated by UHPLC-MS/MS were processed using the Compound</p><p>Discoverer 3.3 (CD3.3, ThermoFisher) to perform peak alignment, peak picking, and</p><p>quantitation for each metabolite. The main parameterswere set as follows:peak area</p><p>was corrected with the first QC, actual mass tolerance, 5ppm; signal intensity</p><p>tolerance, 30%; and minimum intensity, et al. After that, peak intensities were</p><p>normalized to the total spectral intensity.The normalized data was used to predict the</p><p>molecular formula based on additive ions, molecular ion peaks and fragment ions.</p><p>And then peaks were matched with the mzCloud (https://www.mzcloud.org/), </p><p>mzVault and MassList database to obtain the accurate qualitative and relative</p><p>quantitative results.Statistical analyses were performed using the statistical software R</p><p>(R version R-3.4.3), Python (Python 2.7.6 version) and CentOS (CentOS release 6.6),</p><p>When data were not normally distributed, standardize according to the formula:</p><p>sample raw quantitation value / (The sum of sample metabolite quantitation value /</p><p>The sum of QC1 sample metabolite quantitation value ) to obtain relative peak areas; And compounds whose CVs of relative peak areas in QC samples were greater than</p><p>30% were removed, and finally the metabolites' identification and relative</p><p>quantification results were obtained.</p>Treatmenthttps://www.ebi.ac.uk/metabolights/MTBLS138141826610780@qq.com<p>The mice were randomly assigned to 3 groups (n=6): (1) Control group; (2) DSS group: Free access to 2.5% DSS water for 7-14 days; (3) BCP high-dose group (BCP-H): Daily gavage with 200 mg/kg BCP during the experiment, free access to 2.5% DSS water for 7-14 days;</p><p>Following euthanasia, the abdominal cavity was immediately opened and the intact cecum was excised and placed in a sterile petri dish pre-chilled on ice. All subsequent procedures were performed on ice. The cecal content was scraped into pre-chilled sterile cryovials. The vials were then rapidly frozen by immersion in liquid nitrogen for 5 minutes. All samples were ultimately stored at -80°C until further analysis.</p><p><br></p>MetabolomicsIntestinal Barrier FunctionGastrointestinal Microbiomeulcerative colitisuntargeted metabolite profilingIntestinal Barrier FunctionGastrointestinal Microbiomeulcerative colitisuntargeted metabolite profiling<p>Q ExactiveTM HF mass spectrometer was operated in positive/negative</p><p>polarity mode with spray voltage of 3.5 kV, capillary temperature of 320°C, sheath</p><p>gas flow rate of 35 psi and aux gas flow rate of 10 L/min, S-lens RF level of 60, Aux</p><p>gas heater temperature of 350°C.</p>Phe ThrBatatasin IIsenecionan(2S,5S)-trans-Carboxymethylproline3-(2,4-Cyclopentadien-1-ylidene)-5alpha-androstan-17beta-olMonolaurinN-(3-O-phospho-D-ribulosyl)-cadaverineCallicarpenalPiceatannolAlantolactoneYaretol16alpha,17alpha-Dihydroxyprogesterone acetophenideEctoinegamma-GlutamylhydroxyprolineTaraxafolideN-(3-Indolylacetyl)-L-leucinecis-11,14-Eicosadienoic acidLeupeptin Pr-LLEthoxybenzyl diethylenetriamineHierapolitanin D3-[(2-Methyl-3-furanyl)thio]-4-heptanone3-hydroxyvalerylcarnitineisoadenolin C12beta,20-Dihydroxy-16beta-Acetoxy-17-scalaren-19,20-olidePA(i-13:0/i-19:0)CarprofenStrongylodiol Jdapdiamide A5alpha-Campestan-3-onePhlomistetraol Cbeta-CitronellolPhlomistetraol AClusiparalicoline CMyxopyronin BOncostemonol B2'-Amino-2'-deoxyadenosineCimiracemoside DBgugainedapdiamide C2-Amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid4-HydroxybenzaldehydeN-Myristoyl LysinePGB2Azadirachtin MGlucuronic acid sulfateMethylglutaric acid9-cis-Retinoic acidProstaglandin E2Prostaglandin E12-hydroxyoctanoic acidN-Oleoyl-L-SerineHydroxyprolyl-IsoleucineEbeietinonedimethyl 2,4-bis(4-hydroxyphenyl)cyclobutane-1,3-dicarboxylateThermospermineN-Gluconyl ethanolamine15-keto-2,3,4,5-tetranor-PGF2alphaPestalotiopamide ESaniculamoid DFusaric acidEliglustatLithocarpoloneMesuol6-O-Methyl GuanosineL-Theaninecis-Vaccenic acidN1-methyladenosine6-Deoxyerythronolide Balpha-(4-hydroxyphenyl)-N-tert-butylnitroneIsocycloheximideGlyceryl methylmethacrylateHaplacutine FL-phenylalanyl-L-prolineCyclo(deltaAla-L-Val)3,5-Dihydroxy-4-(3',7'-dimethylocta-2',7'-dienyl)bibenzylPerillyl alcoholMethyl deacetylasperulosidateAucherineGelsebanineArginylglycine1-[2-Methyl-3-(methylthio) allyl]cyclohex-2-enol2-Diethylaminoethanol3-Hydroxydodecanedioic acidArterolane12-epi-Fischerindole U isothiocyanateArg Tyr TyrDG(12:0(3-OH)/12:0(3-OH)/0:0)S-(2-Methylbutanoyl)-dihydrolipoamideN6-beta-AspartyllysineHygric acidVindoline2,6-Dimethyldeca-2,4,6,8-tetraenedialMethionyl-ProlineN-(1-Deoxy-1-fructosyl)alanine3,4-Diethylthiophene16-alpha-Hydroxypregnenolone6,8-Dihydroxy-4-methyl-7H-benz[de]anthracen-7-one(S)-beta-hydroxy-L-tryptophanN-BenzyloxycarbonylglycineD-Gluconic AcidTectoionol BPlakorsin B(2S,2'S)-PyrosaccharopineCamaranoic acidAcetylfentanylArdisiaquinone DDG(18:2n6/0:0/20:4n6)Pentyl decanoateN-AcetyllactosamineH-ILE-GLY-OHSoyasaponin II6-MethylluteolinProcyclidineOctaethylene glycolHaemodoronePro Leu LysMycestericin FN-Eicosapentaenoyl AsparagineN-((Tetrahydro-5-oxo-2-furanyl)carbonyl)-L-histidyl-L-prolinamideCleistanthin BAdunctin AKetobemidone3-MethyloxyindolePoricoic acid HM3-Methyl-5-pentyl-2-furanpentadecanoic acid5,6,7,8-Tetrahydro-2,4-dimethylquinolineN-tetradecanoyl-L-Homoserine lactonePlakortolide NPhe-gly4-O-MethylhymenoxonIsobrucine N-oxideN-MethylflindersineEmetaminePterosin B3-MethyladenineProstaglandin G2 2-glyceryl EsterBatilolVertilmicinSieboldine A(rel)IndoleN-(5-Aminopentyl)acetamideFeigrisolide DLysine conjugated deoxycholic acid putativeSM(d18:0/20:3(8Z,11Z,14Z)-2OH(5,6))N-(1-Deoxy-1-fructosyl)valineTrp GluAscorbyl stearateDendrinePE(18:2(9Z,12Z)/15:0)L-CarnitineVenlafaxine3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanateCurcumanggosideLeupeptin1,1-Dimethylpyrrolidinium-2-carboxylaterubiarboside G 28-al3alpha,17alpha,21-Trihydroxy-5beta-pregnan-20-oneN-Lauroyl Glutamic acidAdenosinePinostrobin chalconeEkeberin AN-Benzyloctadecanamide(-)-AphanorphineColletochlorin HL-AlloisoleucineBeta-CortolIndolepyruvate4-(beta-D-glucosyloxy)-3-hydroxy-benzoic acidGelsemideLinoleic acidHirsutinOrthosphenic acid(+)-Epilupinine-N-oxideCampesterolLitsenolide C1Fructosyl-lysine6-Geranylgeranyl-2,3-dimethylbenzene-1,4-diolStagonolide B2,3-Dinor-8-iso prostaglandin F2alphaDauricineGlycylprolylhydroxyprolineArphamenine B(4E)-3-Hydroxyhex-4-enoylcarnitine6-methoxyspirotryprostatin BS-(p-Azidophenacyl)glutathioneSymphytine oxideL-PhenylalanineIsomitraphylline N-oxideCapillaridin GPC(15:0/P-18:0)H-Ser-Phe-OH5,5'-DehydrodivanillateMenaquinoneAsparaginyl-ThreonineAdipoyl-carnitineN-[5-(1-naphthylmethyl)-1,3-thiazol-2-yl]cyclohexanecarboxamideBroussonetone ACernuineAntibiotic KO 7888CCalcimycinMG(i-18:0/0:0/0:0)MesaconineCPA(18:2(9Z,12Z)/0:0)(9Z,12Z,15Z,18Z)-Tetracosa-9,12,15,18-tetraenoylcarnitineCannabigerolLythranidineArginylphenylalanineArginylthreonine12-MethyltridecanalFumifungin9,12,13-TriHOMEHomaxisterol B2Terephthalic acidN,N-Didesmethylgrossularine 1Longithorone BLongithorone E1,1,1-Trifluoro-3-hydroxypropan-2-oneBrunnein ABuprenorphineGelsenicinePuerol AAcetyl-DL-ValineIsoamyl laurateGlutaminylthreonineHemsleyatinePhenylacetaldehydeLysoPE(0:0/16:0)Erythrophloin DN-MethylparoxetinePterosin JHinokitiol glucosideBufotalinDecarestrictin FXestobergsterol B5-Butyl-5-cycloheptenylbarbituric acidXestobergsterol A3-OxobutanoylcarnitineH-Arg-Lys-OH2-(4-Hydroxyphenyl)-1-nitroethaneEthyl linoleateCalyxamine ASterigmatocystinN1,N8-Bis(4-coumaroyl)spermidineCrispine Astellata-2,6,19-triene2,5-Furandimethanol(E/Z)-Ginkgolic acid C17:2FLESTOLOLPrednisoloneHeteranthinD-Erythro-dihydrosphingosine2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-oneBactobolinGlu-Ile-SerDG(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:4(6Z,9Z,12Z,15Z)/0:0)C16 Sphinganine1-(2-Thienyl)-1-heptanoneLeucylarginineTetrastachynine6-nonenoylglycine11Z,14Z,17Z,20Z,23Z-hexacosapentaenoic acidPerseitolComnostin DRegelin7-Acetoxy-5,6-dimethoxycoumarinComnostin A5'-Demethoxycadensin GMonomethyl phthalate9,10-Epoxy-13-hydroxy-11-octadecenoate2-PolyprenylphenolN2,N6-Diacetyllysine4-Methoxy-3-(isopenten-2-yl)acetophenoneSerjanic acidDihydrobotrydialoneDiphenylphosphine oxideDesmaresteneFukiic acidLilifloneSaliniketal BSaliniketal AOctadecanoic acid1-Dehydro-15alpha-hydroxytestololactoneNopaline3,4-Bis(methoxycarbonyl)benzoic acidStemonidine(+)-Cyclotryprostatin BLepidissipyroneMirtazapineStrophanthidolTopsentisterol D3Consabatine4-HYDROXY-6-METHYLPYRAN-2-ONE3-hydroxypalmitoylcarnitineLycernuic acid CPA(18:1(12Z)-O(9S,10R)/a-15:0)9,10-DihydroxyanthraceneMethyl homodaphniphyllatetrans-10-Nonadecenoic acid(C19-1T)PoncirinCroomineOlvanil11-deoxy-PGE13-hydroxybutyryl-L-carnitineLysoPC(17:0/0:0)Sodwanone MPhe-Ala-GlyCalycanthineDG(2:0/0:0/TXB2)Dukunolide C3,4-Dimethoxyphenylacetic acidGanoderol BAcidissiminol epoxide(+)-12-(2-Cyclopenten-1-yl)-2-dodecanone1-Acetoxy-7-hydroxy-3,7-dimethyl-2E,5E-octadien-4-oneKirondrineCafestolFurylacryloylalanyllysineDibenzo-p-dioxin1-O-ethyl-N-acetyl-beta-D-glucosamine3',4',5',5,7-PentamethoxyflavoneLeucyl-leucyl-norleucineL-Cysteic acidN-Ethyl-N-(2-hydroxy-3-sulfopropyl)-3,5-dimethoxyaniline12-HydroxycytisineDehydrogravicycle1,2,3-Trimethoxy-5-ethylbenzenehesperadinMethyl pyroglutamate19(R)-hydroxy-PGF1alphaD-alpha-Tocopherylquinone7-DESHYDROXYPYROGALLIN-4-CARBOXYLIC ACIDTricalysiamide CTricalysiamide Bsyn-3-Isopropyl-6-(4-methoxybenzyl)-4-methylmorpholine-2,5-dione1-Margaroyl-glycerol24-Methylene-cycloartanol palmitateHydroxy-gamma-sanshool(24S,26)-dihydroxycholesterol2-Hydroxyethyl gardenamide AXenimanadin CBlumenol C glucosideAcetochlor esaTrp Pro SerGraphinoneMethyl linoleateNassauvirevolutin ATolnaftateKuguacin LKuguacin KHydroxyprolyl-Asparagine7S,8S-Dihydroxylinoleic acidSubtrifloralactone LH-Leu-Asp-OHN-Linoleoyl ThreonineOctadeca-8,10,12-triynoic acidMucronine BFumariflorineMelazolide AMethyl arachidonateKauraneHeptanoylcarnitinePyropheophorbide-aHyperidixanthoneDiafenthiuronAla-Leu-Ala-Pro9,10-EOTAzacosterol2-Ethyl-5-methylthiophenePyrohyperforinfumonisin B6IsotachiosidePestalotheol CLigulacephalin B4-(2,5-Diethoxy-4-nitrophenyl)morpholinePirbuterol2-Hexaprenyl-6-methoxyphenolbeta-Carboline-1-propionic acidCrotafuran ASM(d18:0/16:1(9Z))Epsilon-(gamma-glutamyl)-lysine(1,2,3-Trimethyl-2-cyclopropen-1-yl)benzene1-Methyl-2-pentyl-4(1H)-quinolinoneConyzanol A2,5-Diethylthiazole7-Hydroxy-2,4,6-trimethoxy-9,10-dihydrophenanthreneMG(22:2(13Z,16Z)/0:0/0:0)Kinabalurine G2-Amino-3-oxoadipatecis-11-Eicosenoic acidWilforlide A[12]-Shogaol3-MethoxyflavoneEgonineNordephrineN,N'-bis[(S)-1-methoxycarbonylethyl]fumaric diamidegamma-glutamylglutamateAmphidinolide FLys Val HisPapaverrubine FMyristyltrimethylaminium bromidePortentol2-Methoxy-6-acetyl-7-methyljuglone5-Ethynyl-5'-(1-propynyl)-2,2'-bithiopheneJuvenile hormone II acid1-pentadecylglycerone 3-phosphateN-AcetylglutamineAzacyclotridecan-2-one19(E)-18-Demethoxygardfloramine-N(4)-oxideBenzidineDG(10:0/0:0/i-14:0)Hierridin BHexadecanoylpyrrolidineN-Eicosapentaenoyl TryptophanDihydrocoumarinCathafuran AGlochidionolactone E3_4_didhydroxypregna5_17_diene10_2carbolactoneGlutamylthreonineCurcumolDesmethylglycitein17-Hydroxylinolenic acidtrans-urocanateN-Caffeoyl serotoninBeloranibNeoglycyrolBiotin sulfoneDitaxinCholestenoneSoyasapogenol ASoyasapogenol B17a-Aza-D-homoandrost-5-en-3beta-olMytilin BPalmitoyl SerinolN-(8-Amino-1-carboxyoctyl)-alanyl-prolineTRPM8 agonist WS-37-Hydroxy-2-methyl-4-oxo-4H-1-benzopyran-5-carboxylic acid 7-glucoside6,18,19-Trihydroxytrachyloban-2-one4-(Phenylamino)benzoic acidL-Valine2-ThiouracilPhenylacetylglycine dimethylamide11-Mercaptoundecanoic acidN-[2-(4-hydroxyphenyl)-2-oxoethyl]-4-methylpentanamideculpinL-Kynurenine7,8-DimethoxymyrtopsinePC(14:1(9Z)/20:2(11Z,14Z))Fruticoside APhaeochromycin ALeu-Ala-GlyCreatineMinoxidilClofibrideFumarylcarboxamido-L-2,3-diaminopropionyl-L-alanine(3S,5R,6S)-5,6-Epoxy-5,6-dihydro-3-hydroxy-8'-apo-beta,psi-carotenalMorinin KLPA(18:1)N-(3-acetamidopropyl)pyrrolidin-2-one4alpha-formyl-4beta-methyl-5alpha-cholesta-8-en-3beta-olLysylvalineDG(20:3(8Z,11Z,14Z)-2OH(5,6)/0:0/i-21:0)Asterelin AOctopine7-Hydroxy-10-methoxydehydrodihydrobotrydialN-Oleoyl LeucinePersicaxanthinKolavic acid 15-methyl esterOxamniquine20-hydroxy-prefusarinSchweinfurthin F24(28)-DehydroergosterolN6-Methyl-2'-deoxyadenosineN-Linoleoyl LysineOLODATEROLN-Eicosapentaenoyl TyrosineStrychnogucine BCorymbi-7,13E-dienolideN-Hydroxy-MeIQxBroussonetine TDoramapimodStallimycinQuisqualic acid(3R)-3,21-dihydroxyhenicosanoic acidBroussonetine HEuparinCarbamorph4-Oxo-5-phosphononorvalineAnthranilL-Isoprenaline(9Z,11E,13Z)-Octadeca-9,11,13-trienoylcarnitinealpha,alpha'-Diethyl-4,4'-bis(2-propynyloxy)stilbene7alpha,12alpha-Dihydroxy-3-oxochol-4-enoatearabinofuranosylguanineEuphol1,6-Dimethoxypyrene3-Hydroxypicolinic acidMiglustatBisucaberin2-Hydroxy-6-oxo-octa-2,4-dienoateTriptolideCalystegin B2(+)-DesoxyscalarinGlycyrrhetic acid 3-O-beta-D-glucuronideSubamolide C6-Hydroxy-5-fluorocytosineGlycohyodeoxycholic acidHomodihydrocapsaicin ICrepenynate1-(3-Carboxypropylcarbamoyl)-5-fluorouracilLeu-Asp-GlnMoxaverineN-Lauroyl ValineCanrenoneanthraniloyl-O-glucosePenisimplicissinPongachalcone IIN-Acetylmethionine sulfoxideGln Leu Val2-Ethyldihydro-3(2H)-thiophenoneGlucitol-lysineN-decanoylglycineKotaninProtopanaxadiol 3-glucoside 20-[arabinosyl-(1->2)-glucoside](3R)-3-hydroxy-12'-apo-beta-carotenal16,16-dimethyl-PGA2Caryophyllene [T(-)]Palmitoleic acidFumarycarnitine3,7-Dimethylguanine3-Methylguanine6-HydroxyketamineAla-Phe-AlaLysoPE(0:0/20:4(8Z,11Z,14Z,17Z))Aglatomin AVinylamycin(E,E,E)-N-(2-Methylproyl)hexadeca-2,6,8-trien-10-ynamide1-Deoxy-1-morpholino-D-fructoseDG(PGF1alpha/0:0/i-21:0)(-)-Solenopsin A3beta-Hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylateHarzianopyridone(5S)-5-HydroxylasiodiplodinBicinePaecilopeptin28-Norurs-12-en-3beta-olThr His ArgHexyl 3-mercaptobutanoateWikstroelide BCaudoxirene(13E,17E)-Polypoda-7,13,17,21-tetraen-3beta-olStearamidePellynol HCE(18:1(12Z)-O(9S,10R))4-acetamidobutanoate3',8-Dihydroxy-4',6,7-trimethoxyisoflavoneComplicatic acidC2-dihydroceramide(2-Aminoethyl)phosphonic acidCortisone acetateEpigomisin O2,3-dilinolenoyl-sn-glycerolPC(14:1(9Z)/PGD2)dihydrocelastrolPE(15:0/14:0)N-(9-oxodecyl)acetamideN-Acetyl mesalazineRidleyamide2,4,14-Eicosatrienoic acid isobutylamideDG(14:1(9Z)/14:1(9Z)/0:0)Lumisterol7-[(2-Benzyl-3-sulfanylpropanoyl)amino]heptanoic acidCorymbiferan lactone ADeoxypeganineDeoxycholylprolineAlboatisin BTyr-tyrN-Methylthreonine1-Dodecyl-2-pyrrolidinoneMilolide KIsoputreanineAcetochlor OAZ-dehydro-Ala-OHGlaucarubinBatzelladine EL-Alanyl-L-leucine11beta-HydroxyprogesteroneCombretastatin A4Nigakilactone ALeu Arg HisAminobenzoyl-glutamate1,3-DIMETHYLURIC ACID(-)-Ceriferol 1CholineO-glutaconylcarnitineLys His GlyFluorometholonecis-9,10-Epoxystearic AcidEthyl N2-acetyl-L-argininateTsugicoline ECARBETAPENTANE3beta,23-Dihydroxy-30-nor-olean-12,20-dien-28-oic acidMonocrotaline[3h]Thienylcyclohexylpiperidine1-NitroaknadininePachyaximine A2-Amino-5-ureidopentanoic acid4'-Hydroxy-3,6-dimethoxy-6'',6''-dimethylpyrano[2,3:7,8]flavoneH-TYR-ILE-OHDesloratadineL-(+)-ArabinoseL-Alanyl-L-prolineNorelgestromin3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanePA(14:0(3-OH)/14:0(3-OH))His His1-arachidonoylglycerone 3-phosphate5alpha,8alpha-Epidioxycholest-6-en-3beta-ol24-EthylcoprostanolAsymmetric dimethylarginineTerretrione BPhlomisoneBremazocineN-RibosylhistidineN-[3-(Dimethylamino)propyl]dodecanamideCadensin AExemestaneIsolinaritriol triacetateAspartyl-ProlineArthrobotrisin AL-Aspartic acidIrregularasulfateGlutaminylalaninePentalenolactone OxanthohumolDehydroabietamide2-linoleoyllysophosphatidylcholineN5-Acetyl-N2-gamma-L-glutamyl-L-ornithineTrandolapril-d5 DiketopiperazineN(alpha)-t-Butoxycarbonyl-L-leucineIsoskimmianineTuberatolide ANanjiol BL-isoleucyl-L-prolineMorusimic acid EGrevirobstol BOctadecyl fumarateLespedezaflavanone G(cyclo(L-Val-D-Ile-L-Leu-L-pro-D-Leu))Linderol A1-Palmitoyl-sn-glycero-3-phosphocholine5alpha-Cholestan-3-one1-MethoxypyrenePYROCATECHUIC ACIDAsn Val LeuR(+)-2-(heptan-3-yl)quinazolin-4(3H)-oneDethiobiotinCryptophorine(Z)-22-Hentriacontene-2,4-dione13-Hydroxy-9-methoxy-10-oxo-11-octadecenoic acidIndole-3-carboxylic acidPeltigerineN-MethylnicotinatePropiomazineOlanzapinePeriplogeninIndicanDi-O-methyldemethoxycurcuminSalvianolic acid FSecopiriferineO-glutarylcarnitineTryptophyl-Alanine(-)-NorpleiomutineLindenanolide G9-deoxy-9-methylene-16,16-dimethyl -PGE2AminoglutethimideHelicinN1,N12-Diacetylspermine4E,14Z-Sphingadiene1,3,6-Trihydroxy-2,7-dimethoxyxanthone1-decanoyl-sn-glycero-3-phosphateL-XyluloseAlibendolIrisoquinLenalidomideBiotinMethyl 15-acetoxy-7-labden-17-oateDaphmacropodineCommendamideResomycin CconiferinLigustrazinenonylphenazoloneValinopine6'',6''-Dimethyl-3',4'-methylenedioxypyrano[2'',3'':7,8]flavoneSyringic acidR-N-DMATDeoxycorticosterone2-(4-Methyl-5-thiazolyl)ethyl decanoatePhe Phe LysLamotrigineFumagillinN-Desmethyl imatinibN-Arachidonyl dopamine8-Hydroxy-2,3,4,7-tetramethoxyphenanthreneImidazotetrazinoneCalodenin BSemiplenamide A5-Nitro-2-(3-phenylpropylamino)benzoic acidVal Arg(Z)-Octadec-12-ene-8,10-diynoic acidTerricollene B4-Methyl-4-aza-5-pregnene-3,20-dioneProlyl-tyrosine20-DihydrodydrogesteroneTerragine AAllyxycarb5,6-Dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinolineClandonensineSemiplenamide ELysoPC(P-16:0/0:0)DicyclominePfaffic acidEstriol5,6-Didehydro-O-methylsugiol9-phenanthryl hydrogen sulfateOxybuprocaineMepiprazoleAmetoctradinIsoalantolactoneN-Acetyl-L-glutamate 5-semialdehydeAdenine monohydrochloride hemihydrate17beta-Hydroxy-4,17-dimethyl-4-azaandrost-5-en-3-oneStoloniferone SPA(8:0/i-15:0)N'-NitrosoanatabineMoupinamideMelamineTenuifolin5-Hydroxytryptophol(8E,15E)-1,8,15-Heptadecatriene-11,13-diyneCoronatineIle Phe Leu7alpha-Hydroxy-5beta-cholan-24-oic AcidCadiamineIfenprodil1-nonadecanoyl-sn-glycero-3-phosphocholineMelicarpinoneCyclo(L-Phe-L-Pro)Quinolactacin APro Glu Ile(E)-2-Undecenal(5Z,8Z)-1,5,8-Heptadecatriene(-)-Tochuinyl acetategamma-SanshoolPE(16:1(9Z)/16:1(9Z))Kudzuisoflavone ADihydroxyeicosatrienoic acid7beta-Hydroperoxycholesterol(+)-Isoaminobisabolenol aChlorpromazineCyclic N-Acetyl-D-mannosamine19(E)-18-demethoxygardfloramineElgodipineKhekadaengoside FTyr Lys TyrIsoamoritinMansumbinoneHydroxyprolyl-TryptophanPA(i-19:0/14:0)H-Leu-Trp-OHHyperibone KPristanalHydroxybutorphanoltrans-ZeatinCilazaprilatGuanfu base ADG(PGE2/0:0/16:0)Asp Pro PheD-alpha-Tocopherol acetateDimethylguanidino valeric acidLeucomalachite green(-)-PohakulinePropionic acid, 2-methyl-2-((piperidinomethyl)thio)-Loganetin23-Acetoxysoladulcidine2,6-dimethoxybenzoylsalicylhydrazideColumbingamma-Hydroxy-3-pyridinebutanoatePindololIsocurcumenolHuperzine BCurdioneC16 Sphingosine1-Acetyl-2-methylcyclopenteneDiacarnoxide CCppeneDiacarnoxide AThr Leu ThrPuromycinTragopogonoside AN-Arachidonoyl ArginineDG(18:4(6Z,9Z,12Z,15Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)4-O-beta-D-GlucopyranosylfagomineIsoeugenolPalmatine9-[(methylthio)nonyl]thiohydroximic acid14-Hydroxyplatensic AcidMetalaxyl-M14-AcetylperegrinePumiliotoxin 251Dalpha-L-FucpNAc-(1->3)-D-FucpNAcHalisphingosine AJaspaquinol1-Phenyl-2-thioureaGly Arg AspFumagillol2-Methylthio-N6-(delta2-isopentenyl)adenosineHuperzine LArgininosuccinic acidThr-Trp8H-cyclopenta[a]acenaphthyleneConfluentin19-HydroxyconopharynginePyriferine C2-amino-1,3,4-tetradecanetriolPhenylalanylphenylalanine(S)-Panaxjapyne AHypoloside A13,14-seco-Stigmasta-9(11),14-dien-3alpha-ol3,4-Dihydroxy-L-phenylalanineMyristelaidic acid2,8-Dihydroxy-1,7-dimethyl-6-vinyl-10,11-dihydrodibenz[b,f]oxepin3-O-(alpha-L-rhamnopyranosyl)-D-ribitol3-Oxo-7-hydroxychol-4-enoic acidFastrinePro Ala HisIndicanine CN2-Acetyl-L-aminoadipate semialdehydeLysylalanineN-(4-Hydroxyphenyl)-eicosa-5,8,11,14-tetraenamideMitomycin AMicrolepinGalanganalCortexoloneCurcumenoneBrexpiprazole5-AMINOLEVULINIC ACIDbeta-ZearalenolGibberellin A123Phenylalanylvalinebeta-Thujaplicintrans-Cyclosuffrobuxinine(+/-)-DihydroactinidiolideClathrin AHypercalin BIle Val Phe12-DeacetylhyrtialDG(10:0/16:1(9Z)/0:0)ModiolinMethylisatoidQuadrangularic acid HStreptidine 6-phosphateDL-alpha,epsilon-Diaminopimelic acidPhlebotrichinAcanthovagasteroid AHovetrichoside HPROCAINAMIDEPolyphyllin HGerberinol I4,4'-Diapophytofluene8-MeSO-octyl-CO2HTyr Pro Val8-hydroxy-13Z-octadecene-9,11-diynoic acid5-(2-Propoxyphenyl)-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-oneEgtazic acidSemilepidinoside BNefazodoneGoniothalamusinbeta-fenchocamphoroneLysoPC(16:1(9Z)/0:0)Dihydrosanjoinine APalythoalone BAustradiol acetateH-D-Tyr-val-gly-OHVal Val IleMikanialactone8'-Epicleomiscosin AMet MetCorrinsitostanetriolMasoprocol11,17-Dimethyl-5alpha-androstane-11beta,17beta-diolH-TRP-SER-OHMortivinacin BPassiguatemalinDimethylsphingosinecrotonyl-L-carnitineent-13E-Labdene-2alpha,3alpha,8alpha,15-tetrolKoelpinin A4,4'-DiaponeurosporenePacificanone ADG(PGF1alpha/0:0/i-15:0)13,14-dihydro-15-keto Prostaglandin J2Coproporphyrin IIIO-palmitoleoylcarnitineGentianainebeta-TocotrienolrutamarinVolinanserin2'-Deoxymugineic acidArachidonoyl ethanolamideEthyl 3-(methylthio)propionateEstra-1,3,5(10)-triene-3,6beta,17beta-triol triacetateStapfinineDioctyl Phthalate3-hydroxypristanic acidVal Asp LeuAcepromazineSM(d18:0/22:3(10Z,13Z,16Z))4-Keto-clonostachydiolTrietazineDecahydro-6-(phosphonomethyl)-3-isoquinolinecarboxylic acid14,19-DihydroaspidospermatineKnightalbinolIsofebrifugine3,4',5,6-Tetrahydroxy-3',7-dimethoxyflavone 3-glucuronide6-LactoyltetrahydropterinFormylfusarochromanone4-(1-Ethyl-2-phenylbutyl)phenolPhenacetinMitoxantrone11-HydroxyrankinidineDihydroartemisinin(+)-ValenceneLotaustralinProgeldanamycin19-DemethylreblastatinLysoPA(22:5(7Z,10Z,13Z,16Z,19Z)/0:0)PipernonalineMilbemectin(-)Arterenol2-(3-Carboxy-3-aminopropyl)-L-histidineCarvyl acetateAbacavirThalsimineHomostachydrineRhodamine BHosloppintrans-4,5-Dihydroxy-4,5-dihydropyreneO-methylmalonylcarnitineStriatisporin ARubipodanone AMagellaninoneYakuchinone ACanavanineS-(1-Propenyl)-cysteine sulfoxide28,29-Epoxyplukenetione ALeu-Leu-Asn6-(Methylthio)purineSaikogenin FN-BenzylpalmitamideHydrocortisonetetradec-5-ynoic acidLeu-Leu-AspGenipinMANNOHEPTULOSEGriffonianone BGrifolinPC(18:1(9Z)/18:1(9Z))Thr Leu PheatenololDimethyl pimelimidate2-Hydroxy-3,4,7-trimethoxy-9,10-dihydrophenanthreneStachyline D4'-HydroxyisolonchocarpinConsiculinePiperphilippinin VDehydrocarvacrol4-Amino-4-deoxychorismateKanosamine 6-phosphate(-)-CryptoresinolDoxofylline3,11-Diketofusidic acid(E)-3-(2-(1H-Tetrazol-5-YL)vinyl)-6-fluoro-1H-indole2-Naphthalenethiol(-)-N-(2-Oxopyrrolidinomethyl)cytisineLysylphenylalanineCodeineTricalysioside M2-(4-Methyl-5-thiazolyl)ethyl hexanoateCamellimidazole F(-)-BestatinTricalysioside HLys Ile Ser3'-HydroxyamobarbitalTricalysioside TTherafectinTricalysioside RDihydrosinapyl alcoholGlu-ProN-Ornithyl-L-taurineVitamin K1 oxide4-Mercapto-5-methyl-3(2H)-thiophenone4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8-en-3beta-olH-Met-Phe-OHAllantoinO-Methyloduline4-ChloroanilineApo-10'-zeaxanthinalCalicoferol GAspyridone BKushenol A10-Oxabenzo[def]chrysen-9-oneClovanediol DiacetateMethylrocaglate27-HydroxycholesterolHis Lys LeuAsp Asn HisSparfloxacinVasnetinePseudoconhydrine4,7-Dihydro-5-(4-methyl-3-pentenyl)-1,2,3-trithiepinCoccuvinePosoquenin1-Aminocyclohexanecarboxylic acidFellutanine DAconasutineDaphnezomine AAspidospermidose2-Phenylethyl formatePA(18:1(12Z)-2OH(9,10)/2:0)cotinine-glucuronideVal Thr GlnN-Lauroyl Cysteine1,6,10-Phytatriene-3,5,14,15-tetralLinalyl acetateNe,Ne dimethyllysineLimazocic3alpha,6alpha-Dihydroxy-5beta-pregnan-20-oneyanuthone IRengyoside BAnnomontineMethyl cholate2'-DeoxycytidineThunbergol A15-(3-Methyl-5-pentylfuran-2-yl)pentadecanoylcarnitine12-Epinapelline5'-N-MethylcarboxamidoadenosineIle Phe GlyCinnamyl Alcohol4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanolCanusesnol ACorticatic acid AN-cis-11,14-eicosadienoyl ethanolamineCaryophyllene oxideDopexamineGarcinielliptone FA7-deacetyl-7-benzoylepoxyazadiradioneNAlafuzhuanin A(22S,23S)-28-HomobrassinolideL-Norleucine1-Acetyl-8-hydroxy-beta-carbolineMiraxanthin-VHis Pro AsnXylobiose(S)-2,2,3-Trimethyl-3-(4-methylphenyl)cyclopentanoneAminomethanesulfonic acidRoridin ARoridin DCoronaridineLepadiformine BLumacaftorHis Phe Arggamma-GlutamylasparagineHydroxyprolyl-Proline(+/-)-10-HDoHELongirabdolide F(-)-Floridinine10-DeacetoxybarbilycopodinNepodinEstrane3-METHYLQUINOLINE3,4-Dimethyl-5-propyl-2-furanpentadecanoic acidDehydrodeguelin5alpha-Cholestan-5alpha,6beta-diolLys Leu7-octenoylglycineGlu-GlyRugulovasine BLeu-Ala-Ser2,2,5,7,8-Pentamethyl-6-ChromanolPA(18:1(12Z)-O(9S,10R)/14:0)2-n-Propylthiazolidine-4-carboxylic acidTumonoic acid DIndolelactic acid6-Hydroxy-4-heneicosanoneMaltotetraoseStaudineDG(TXB2/0:0/16:0)gamma-L-glutamyltyraminepiperaquineHypoglycin B(+/-)-Huperzine ABuddledin AIsopentenyl pyrophosphate8,11,14-EicosatrienoylethanolamideEmtricitabineOogoniol 2(3,4,5-trihydroxy-6-methyloxan-2-yl) 2-(methylamino)benzoate11beta-HydroxyandrosteroneCerevisterolPhorbasin HNebularineHimbacineLauramine oxideWithangulatin CStizolamineN-Palmitoyl phenylalanineN-Oleoyl Glutamic acid4-Isopropenylbenzaldehyde8-OxoadenosineSibiricinone DEndalin4,4'-Methylenebis(2-chloroaniline)3,4,17-trihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9-oneHirsutellide AHaemulcholate(-)-10-Methoxyvincamedine N-oxidePC(LTE4/2:0)7,12-Dimethylbenz[a]anthracene 5,6-oxideCaloflorideYezoquinolide4-Deoxypyridoxine17-Methyloctadecanoic acid4-Methoxy-2-methyl-N-phenylanilineLys Leu SerSkullcapflavone IILysinoalanineascaroside C6Itoside LCenobamate2-glyceryl-11,12-EETalpha-L-Rhamnosealpha-EucaineKobusin3-Ketodehydrosulfurenic acidL-Gulose3-o-acetylbotcineric acidcis-13,16-Docosadienoic acidOphthalmic acidDG(10:0(3-OH)/16:1(9Z)/0:0)DG(8:0/10:0/0:0)Oxindole2-(Undec-3-enyl)-4-quinolinoneFluasterone(1xi,3xi)-1,2,3,4-Tetrahydro-1-methyl-beta-carboline-3-carboxylic acidHomocitrulline3'-Acetylindicine N-oxideDesacetylcinobufotalintrans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene5-(N-Methyl-N-isobutyl)amilorideArisugacin CDeoxynojirimycin Tetrabenzyl EtherThioridazine 5-SulfoxideTupichigenin D13,14-dihydro-15-oxo-20-carboxy-PGF2alphaTupichigenin BPurineDidanosineBryophyllin C1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid 8-quinolinyl esterPro Pro ValSinularioloneLysoPE(20:4)ValylhistidineLycoposerramine DPromethazinecandidone1,3,7-TrimethylisoguanineSugikurojin IPutaminoxin EHistidinolMG(P-18:0/0:0/0:0)2-Propanol, 1-((1-methylethyl)amino)-3-(2,4,6-tripropylphenoxy)-1-Isothiocyanato-8-(methylthio)octaneChrycorinHyrtioerectine BL-Glycyl-L-TryptophanBactacineN-Oleoyl GlycineEthylmalonic acid4,5-Dimethoxycanthin-6-oneN-(1-Deoxy-1-fructosyl)leucinePoststeroneN-(gamma-L-glutamyl)-L-alaninolOkaramine PCucurbitacin IOkaramine QPhe AlaMaltotrioseArbutin2-NaphthaldehydeIsomahubanolide 23DiaziquoneOdonticinCampyrone CL-Methionine5-borylporphineN(6)-glycyl-L-lysineN-(1-Deoxy-1-fructosyl)prolineLinustatinNicotinamidePenidienone2-amino-1,3,4,5-icosanetetrol4-Methylumbelliferyl heptanoatezinolol4-(gamma-L-glutamylamino)butanal3beta -Ursodeoxycholic acidIeodomycin ATryptophanamide1-(2,3-Dihydro-6,7-dimethyl-1H-pyrrolizin-5-yl)-2-hydroxy-1-propanonecis-Isolimonenol3-methoxymorphinanN-AcetylornithineDendroside F1-FormylneogrifolinSM(d17:1/18:0)zinniolPicolinic acido-Desmethyl ranolazine1-AG17-Isovaleryloxygrindelic acidCoumeroic acid(2S)-2,7-dihydroxy-5-methoxy-6,8-dimethylflavanoneHis Gln GlyProtostemotinine1',8-DihydroaplysinopsinAntimycin A8aPenitrem A19-(3-methyl-butanoyloxy)-villanovane-13alpha,17-diol24,24-Difluoro-1alpha,25-dihydroxyvitamin D3O-propanoyl-carnitinePyridoxatinAigialone7beta-Hydroxycatuabine IAurachin BUstiloxin DTupichilignan APE(14:1(9Z)/18:0)Ustiloxin FHexoprenalineCholesterol-5beta,6beta-epoxide10-MethyltetradecanoylcarnitineCelgosivirdihydrocelastryl diacetate5-(10-Nonadecenyl)-1,3-benzenediolMoralbanone2-Chlorooctadecanoic acid(-)-Terpendole C1-Hydroxy-2,2,5,5-tetramethylpyrrolidine-3-carboxamideArmepavineHormodirene4,7-Dioxoheptanoic acidAntheridic acidAmrinoneSM(d20:1/PGF1alpha)Salinosporamide GHalisulfate 8Aegeline1-Acetoxy-7-hydroperoxy-3,7-dimethyl-2E,5E-octadien-4-oneN-Lauroyl Aspartic aciddendrobaneDG(i-18:0/0:0/PGJ2)PinazepamAditoprimPyricarbateArbutamineBortezomibMethyl 2alpha-hydroxyoleanolatePyrimethaminePerseal CDidesethyl ChloroquineTyr Asp Asn3-geranyl-2,4,6-trihydroxybenzophenone28-NorbrassinolideDeidaclinEffusolCryptomoscatone D2Ethyl pivaloylacetateEplerenoneMycocyclosin(-)-Aristeromycin6-Acetamido-3-oxohexanoate4-GuanidinobutanalTraumatin1,5-Dihydroxy-2,3-dimethoxy-10-methyl-9-acridoneDyclonine10,13-Dimethyl-11-docosyne-10,13-diolN-Alpha-acetyllysineIeodomycin CLysyllysineSolandelactone CO-Desmethyl GalanthamineN,2,3-Trimethyl-2-(1-methylethyl)butanamideJerantinine HTHTCAla-Asp-ProJervineTriandrinRoburic acidCalyciphylline OPochonin FTrp Lys GlnN2-(gamma-Glutamyl)-4-carboxyphenylhydrazine19-ChloroproansamitocinSolandelactone G2beta-5,7-TrihydroxyflavanoneEstetrolPC(14:1(9Z)/14:0)trans-1,2-DiphenylcyclobutaneDihydrocodeineD-Ribo-phytosphingosineThonzylamineL-2-amino-8-hydroxydecanoate2-[4-Methyl-2-(2-methylpropoxy)phenyl]-oxiranemethanolalpha-Asp-Ile(+)-Rishirilide BPro-Pro-PheMiltironeGlyceryl tri(2-ethylhexanoate)SotrastaurinHerbimycin BVogelin HVogelin IProstaglandin F2aPedatisectine D3beta-Hydroxy-17-(1H-imidazol-1-yl)androsta-5,16-diene8-methylhomobotcinolideAspochalasin KClafenIsopentenyladenosine2'(R)-HydroxylanneaquinolCyclo(Tyr-Leu)7-O-demethyl-albocyclineVariecoacetal BNefopamLeu-Leu-Ser1-Thiocarbamoyl-2-imidazolidinoneLaprafyllineMiuraenamide FDL-O-PhosphoserineProtoverineLysoPS(18:2(9Z,12Z)/0:0)MG(20:2(11Z,14Z)/0:0/0:0)CE-108E aglycone1-Stearoyl-sn-glycero-3-phosphocholineHistidylleucineMethyl phenyl sulfideCyclo(L-Leu-L-Pro)3-HYDROXY-4-(SUCCIN-2-YL)-CARYOLANE delta-LACTONE(R)-SulforaphaneAnandamide (20:l, n-9)VogliboseBlacknidineAllithiamine15-hydroxyangustilobine AIsoeugenol acetateN-Stearoyl Glutamic acidChrysarobinDECARBOXYHYDROXYCITRINONEFicuseptine CNicotinic acid ribosideFenitropanN-Stearoyl ProlineVerrucarin K2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline(+)-GalwesinePolyprenyl phosphateSalacenonalKopsamidine AMethylripariochromene AIlekudinol A(7Z,10Z,13Z,16Z)-DocosatetraenoylcarnitineChaxalactin BPentagydinedemethylpremithracinoneSlaframineTofacitinibCarboprostItoprideCrassifolazonine(2S,3S)-2-Hydroxytridecane-1,2,3-tricarboxylateNeopterinHexanoylcarnitineBrassicasterolSafracin ANordercitinBreyniaionoside AH-Leu-Asn-OH4,4',alpha-Trihydroxy-2'-methoxydihydrochalconePhe-Pro-IleL-Pipecolic acid5,7-DimethoxyluteolinSargachromanol MAlectinibDemethoxycurcuminalpha-Phocaecholic acid4-Methylene-L-glutamineErgosta-4,6,8(14),22-tetraen-3-one5-(8Z,11Z-Heptadecadienyl)-1,3-benzenediolArginylglutamine6-(alpha-D-glucosaminyl)-1D-myo-inositolPhenylalanylserineAcuminatinPolyvidoneGlutaminylprolineDl-MevalonolactoneGlutaminylglycine3,5-Didecanoylpyridinegamma-Glu-GlyphenylalanyltyrosineL-Proline, 1-(1-L-leucyl-L-prolyl)-(-)-Falcarinolgamma-GlutamylphenylalanineHyacinthacine C12,3-dimethylidenepentanedioylcarnitineOleamide3-(2-Hydroxyphenyl)propanoic acid4-Amino-5-hydroxymethyl-2-methylpyrimidine(S)-N-(4,5-Dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)alanineN,O-Didesmethylvenlafaxine1,9-PyrazoloanthroneKainic acid4,7-Dimethyl-1-tetraloneN-Acetyl-D-mannosaminolactoneN-(6-Aminohexanoyl)-6-aminohexanoateandiconinIsouramilAcetaminophen cysteinFruticolide (sesquiterpene dimer)Neovasipyridone CN-arachidonoyl dihydroxypropylamineEriosemaone C17alpha,20alpha-Dihydroxycholesterol(+)-NuciferalValyl-Gamma-glutamateLeu Val Ala4-O-alpha-CadinylangolensinRo 20-1724IsolonganoneDansylamideLachnumfuran A21-Hydroxypregnenolone2,3-diepi-25-MethyldolichosteroneD-erythro-SphingosineNothofaginalpha-Cyclogeraniol acetateLanyuamide IIIMupirocinKleinioxanthrone 2ChromoarnottioneLasiocarpine N-oxideBotcineric acid7alpha-HydroxysophoramineLeucyl-4-hydroxyprolineLapidolidinH-LEU-LEU-ALA-OH12'-Apo-b-carotene-3,12'-diolDesfesoterodineN-Acetyl-leucyl-leucyl-norleucinalAsparaginyl-ValineMarinoquinoline C2-(undec-1-en-1-yl)quinolin-4-ol:Series 2 HAQ C11:1Griffinisterone DGriffinisterone CGriffinisterone BEvocarpine5-Fluorocytosine5,6-dehydro Arachidonic Acid2beta,3beta,4beta-Trihydroxypregnan-16-one2-OctenoylcarnitineMaculosine2,7-AcetylaminofluorenePodecdysone B18-Nor-4(19),8,11,13-abietatetraeneAdenosine monophosphateZahavin AN(alpha)-Benzyloxycarbonyl-L-leucine9-methoxy-2,2-dimethyl-6-hydro-2H-pyrano[5,6-c]quinolin-5-oneAllopurinolRemangilone BHeptadecanalLeu Ala Lys2-Hydroxyestradiol3,6,9,12-Tetraoxatetracosan-1-olDICYCLOHEXYLCARBODIIMIDE4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-olN-ArachidonylglycineMagnoshininPersin[8]-ShogaolBouchardatineDiisopropyl sulfidePE(16:1(9Z)/14:0)Caffeine, 8-((3-methoxypropyl)amino)-StearylcarnitineTournefolin BDG(8:0/0:0/5-iso PGF2VI)TalatisaminePeimineDodecanamideNorselic acid CSebacoyl-L-carnitine17beta-Hydroxy-2alpha,17-dimethyl-5alpha-androstan-3-onetropan-3-oneStearidonic acidCelerioside EAnhydrofulvic acidBrassicicene BAsparaginyl-Tryptophan4-[[2-[(E)-1-hydroxybut-2-enyl]-5-oxooxolan-3-yl]amino]benzoic acidPectenotoxin 1ubiquinone 25EcgonineAla Leu Glu10-(2-(Diethylamino)propyl)-10H-pyrido(3,2-b)(1,4)benzothiazineChlorantene BDiazaquinomycin A(+/-)-2-Propyl-4-pentenoic acidPropericiazine3beta-acetoxy-17(21)-hopen-1-oneTetrahydrocortisone7beta-Hydroxy-23-deoxojessic acid3-oxo-N-[(3S)-2-oxopyrrolidin-3-yl]dodecanamidebis-(4-hydroxybenzyl)sulfide5alpha-Cholestan-3beta-olalpha-5-C-(3-Hydroxybutyl)-hyacinthacine A2[R-(E,E)]-13,14-Dihydroxy-6,10,14-trimethyl-5,9-pentadecadien-2-onebeta-sanshoolNorclozapineMonocillin III17beta-Amino-5alpha-androstan-11beta-olJayantinindelta-Guanidinovaleric acidEstradiol 17beta-cyclopentylpropionateLinoleamide MEAHydramethylnonDelbrusineLyaloside12-DeoxywithastramonolideMethiocarb-sulfoxideSclareolideAICARBisdihydrotrifarinN-HydroxyannomontineGinsenoyne A linoleateAcremolide B4-[(4'-O-Acetyl-alpha-L-rhamnosyloxy)benzyl]isothiocyanateAspernidine BDynorphin B (10-13)6alpha-Angeloyloxy-4alpha-hydroxy-3,4,13,14-tetrahydrokolavenic acidRICININE4,4'-DiaminodibutylamineTroxilin B3GuanineBombykol(+)-Anhydro-beta-rotunolMuridienin 4N-(3-Hydroxypropyl)valinePropionamide, 3-anilino-N,N-diethyl-4,4'-Diapo-zeta-caroteneLeukotriene D4 methyl ester11,12,13-Trinor-6,9-eremophiladien-8-onehexadecanedioic acid mono-L-carnitine esterMalabaricone CMalabaricone BN-Acetylserine8(9)-EpETrE-EA6-oxopristimerol5-Methylpyrogallol sulfatePE(15:0/18:2(9Z,12Z))3-Methyl-(triazen-1-yl)imidazole-4-carboxamideMahanimbinolH-TYR-TRP-OHCivetolAnhydrovitamin A1L-tyrosyl-L-valineEuparvic acidPhytophthora mating hormone alpha1N-Heptanoylhomoserine lactonedihydroartemisinic acid hydroperoxideN-AcetylisoleucinePA(i-19:0/12:0(3-OH))StizophyllinPseudolycorine17-oxo-RvD18'-apo-beta-CarotenolL-ArogenateIsotaifineKadsulignan LKetanest3beta-Hydroxy-5-cholestenoic acidDihydroflexibilidetriazolopropionic acidL-2-Aminoadipate 6-semialdehydeAdelmidrolTylopiol BAspartylhydroxyproline18-Isovaleryloxygrindelic acidLeuzeasterone2'-FucosyllactoseN-Oleoyl Glutamine3beta-Fluoro-5beta-pregnan-20-oneSM(d18:0/16:0)N6-CarboxyethyllysineZingerone25-O-Methylcimigenol(-)-PyrifolidineTerreusinollinoleylcarnitineHyacinthacine B1Ibuprofen3beta,4alpha,13alpha-TrihydroxylupanineN-Lauroyl AsparagineThalidomide-5-OHent-AprepitantPauciflorine BMonanchorinNeorustmicin BThreonylprolineSELENOCYSTAMINE1-O-hexadecyl-2-C-methyl-3-phosphatidylcholine4-Hydroxyoctanedioylcarnitine2,3-dimethyl-6-phytyl-1,4-benzoquinol4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]butanoic acid6-DeoxypenciclovirDibutyl adipateD-Arabinitol 1-phosphate(+)-vulgraon BBenzofuran2-Propenyl 3-(2-propenylsulfonyl)-1-propenyl disulfide(+)-N(6)-HydroxyaphelandrineAgomelatineGarcinone CDG(i-20:0/0:0/TXB2)2-Amino-3,4,8-trimethyl-3H-imidazo[4,5-f]quinoxaline(+/-)-2-Methylthiazolidine3,4-Dimethyl-5-pentyl-2-furantridecanoic acido-Toluic acidAkeboside Stf3,4-Dehydro-gamma-tocopherolClonostachydiolSterequinone EAxiplyn ELycoflexineDeacetylspiramine STiagabineVernoguinosterol2-Amino-2-deoxy-D-gluconateHistidylprolineamideN-Arachidonoyl MethionineZILEUTONProlyl-GlutamineAngustilocineAllopurinol riboside3-ketosphinganine5-methoxy-L-tryptophan3-Methyl-19-nor-17alpha-pregna-1,3,5(10)-trien-17-olDehydrodictysinePC(15:0/20:4(5Z,8Z,11Z,14Z))Dulciol DPeiminineDelpheline3-KetosphingosineMeisoindigoSemiglabrinolplakortone PoregoninPALMYRROLINONEN-AcetylkynurenineTeucrolin FKirenolTyr Ile TyrN-D-GlucosylarylamineTymazolineN-CyclohexanecarbonyltetradecylamineBetaenone DDL-EthionineDiglyceryl monooleateDehydrobisgravillolGlycohyocholic acid4-HydroxyisoleucineArthrobactin(-)-ClathrotropineSolorinineAllantoxanamide4-[(E)-3-hydroxy-8,10-dimethyl-2-(methylamino)dodec-6-enyl]phenol4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline(+)-Zippelineoleoyl ethanolamideStereumin JQuinocarmycin analogGamma-Glu-LeuBixinm-TolualdehydeChalcomycin(+)-N-Deoxymilitarinone A1-Tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-aminedeoxycarnitineN,N-DimethylguanosineMecarbinategamma-Eudesmol 11-alpha-L-rhamnoside11alpha-HydroxypoststeroneCryptofolione3,3-Dichloro-propionic acid13,17-Epoxy-16-hydroxy macrolactin AEuropine N-oxide(E)-4,8-Dimethyl-1,3,7-nonatrieneDelta(1,7)-dafachronic acid2',3'-DihydroamentoflavoneApo-8'-capsorubinalArteglasin AN-acetyl-S-(3-oxo-3-carboxy-n-propyl)cysteineSer Glu ArgDOPA sulfateSM(d18:1/18:1(9Z))2-Amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridinePleurogeninSinetirucallolbeta-Aflatrem5-Hydroxyindole-3-acetic acidLeu-Leu-LeuApocholic acidEnicoflavineDi-n-decyl phthalateGanoderic acid A10-GingerdioneDiosbulbin BAcanthoaustralide2-14,15-EGIsohernandezineEthyl leucinateLysoPA(18:2(9Z,12Z)/0:0)2-(4-Chlorophenyl)-3-phenyl-3-(2-pyridinyl)acrylonitrile2,3-DideoxycytidinePE(15:0/16:1(9Z))12-AcetyldehydrolucidusculineL-Alanyl-L-tryptophanCyclopentenyl cytosineArginylargininedesmethyl tocotrienolGlycerylmonooleateCognatine2-Dimethylamino-5,6-dimethylpyrimidin-4-olH-LEU-LEU-GLY-OH(S)-3-Methylthiohexyl acetateAmmelideHis Thr LysAmiflaminabreynceanothanolic acidL-TryptophanImidazolone ABlonanserinCropropamide2-Amino-1-phenylethanolDendrinolideChlovalicinThioctic acid12-Hydroxypterosin T17beta-Hydroxy-5alpha-androstan-3-one cyclohexanecarboxylategamma-TocopherolN-MethyldioctylamineProlylhydroxyprolineDeferitrin3-MethyldioxyindoleTenuifolide B(Z,Z,Z)-3,6,9-Dodecatrien-1-olIle IleN-(3-Indolylacetyl)-L-Alanine1,2-Diazenedicarboxamide4-Methoxyindoxyl sulfateMelleolideValdivone AEnallylpropymalCedryl acetateTryptamineN-Nervonoyl MethionineNopalinic acidCHOLESTEROLLysoPE(0:0/18:3(9Z,12Z,15Z))Santacruzamate AMorphineStreptazone Aalpha-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanolIso-precytochalasinCysteinyl-Histidine8-Oxo-2'-deoxyadenosineCamoensidine N-oxideDendronpholide MDendronpholide LKuwanon BO-(2-Aminoethyl)-5Z,8Z,11Z,14Z-eicosatetraenoate16-Heptadecyne-1,2,4-triolKermadecin ERetapamulinPalmitoyl glucuronideDichotomine BLongithorol CDichotomine COleylcarnitine9-Hydroxyoctadecanoic acid4Z,7Z,10Z,13Z-hexadecatetraenoic acidN-(4-Amino-2,5-diethoxyphenyl)benzamideDeoxyguanidinoproclavaminic acid6-n-OctylaminouracilNeodunolDiisobutyl adipateLeptofuranin DFicuseptamine ALysylprolineHydrogenated MDI(7Z,10Z,13R,14E,16Z,19Z)-13-hydroxydocosapentaenoic acidDipentyl phthalateNostocyclyne ANemorosone II6,10,14-Trimethyl-2-methylenepentadecanalIle Asn PheLaxiracemosin HPi-Methylimidazoleacetic acidSesbanimide CLeu-Phe-AspSesbanimide AD-GLUCOSE-6-PHOSPHATEAzadironol(plusmn)7-epi Jasmonic AcidAsparaginyl-ProlineHypaphorine2alpha,3alpha,19alpha-Trihydroxy-28-norurs-12-eneNoraugustamineDocosatetraenylethanolamideL-2-amino-8-hydroxyoctanoateSecaubryolideL-DihydroanticapsinMembrenone ASpeciosin KEthephonp-OctopamineKermadecin CMayosideDihydroisoderrondiolThiomorpholine 3-carboxylateTetradecanalhemiasterlinAchaetolidePhomamideSM(d18:0/20:4(7E,9E,11Z,13E)-3OH(5S,6R,15S))alpha-Tocotrienolgamma-GlutamylarginineHirsutine2-Nonylquinolin-4(1H)-oneTrp Gln GlnDimethylglycineOleandolidePlatenolide ATerpendole EN(5)-Acetyl-L-ornithineCorchorifatty acid FPro Gln TyrVal Val PheStemonine5alpha,9alpha-Epidioxy-(22E)-ergosta-7,22-diene-3beta,6beta-diolDeethylatrazine1-(1-Hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-1h-pyrrole-2,5-dioneChitobiose4a-Carbinolamine tetrahydrobiopterin14-HydroxyisostephodelineTerezine BTerezine ALysidicichinMethyl pentadecanoateArg Glu Leu2'-HydroxyzearalanolLachnumlactone AGlu Glu IleVistusertibPA(a-21:0/a-13:0)N6-Galacturonyl-L-lysineLeu-Gly-ProPhysalin BL-FurosinePhormidinine BMethyl tumonoate AMyristamine OxideEsculin(+/-)-2-Phenyl-4-methyl-2-hexenal2,3-Dihydroxypropyl 16-hydroxyhexadecanoateCalcitroic acid3-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dionePhysalin M5-Methyl-3-farnesyl-3-hydroxycoumaraneValyllysinedemethoxyegonol4-[2-(Methoxycarbonyl)anilino]-4-oxobutanoic acidH-Ser-Leu-OHSericetinPaucineETHANOLAMINE PHOSPHATE9-MethyltricosanoylcarnitineMethyl (9Z)-6'-oxo-6,5'-diapocaroten-6-oateValylhydroxyprolineLeu-Val-SerResolvin D1(-)-StephabinamineCorchorifatty acid B7-dehydroporiferasterol19-norcholesta-1,3,5(10)-trien-3-ol9Z,11E-Tetradecadien-1-ol6-MethoxygossypolDodec-8-enedioylcarnitine5-(Heptadec-12-enyl)resorcinolIgernellinSachaloside VI1-MonomyristinAnagliptincyclic 3-Hydroxymelatoninmethyl 3,4-dihydroxy-5-(3'-methyl-2'-butenyl)benzoateQuinacridone4,5-Dihydromelampodin BTranexamic acid3-Amino-4-hydroxybenzoatePC(20:4(5Z,8Z,11Z,14Z)/20:4(8Z,11Z,14Z,17Z))1beta-Hydroxymakisterone C8-iso-16-cyclohexyl-tetranor Prostaglandin E2Cyclo-(Leu-Tyr)Diallyl disulfide1-(1-(Tert-Butoxycarbonyl)piperidin-4-yl)azetidine-3-carboxylic acidN-Acetylputrescine7-Hydroxyguanine3-O-Methyldopa8Z,11Z,14Z,17Z,20Z,23Z-hexacosahexaenoic acidDL-Leucyl-DL-phenylalanineCordycepin3-Hydroxy-beta-iononeBroussonetine M1BigelovinL-GlutamineCREATININEIsoaaptamineNeostenineDolichol phosphateSuccinic acid monoethyl esterDiinsininAnagyroidisoflavone BFluorocarazololCyclo(4-hydroxy-R-Pro-S-Leu)3-hydroxy-4-methyl-D-kynureninePropenoylcarnitinePolanrazine EN-AcetylmuramateRoccaninGymnasterone CIsodomoic acid DGymnasterone DLinoleic acid amideHoladysenterinecis-4,7,10,13,16-Docosapentaenoic acidLeu Ile Glu5alpha,17alpha-Pregn-2-en-20-yn-17-ol acetateMethyl aphyllateStephabyssine(+)-CodonopsineLyso-PAF C-16CodlemonePiscidic AcidIsovouacapenol Call-trans-4-Oxoretinoic acid(S)-10-HydroxycamptothecinFotemustinaArg Leu4,4'-Methylenebis(2,6-di-tert-butylphenol)N-Arachidonoyl Threonine9H-Purin-6-ol, 2-((phenylmethyl)amino)-Platenolide B mycaroseMethyldopa anhydrousCalenduloside EC17-SphinganineAllylestrenolIrbesartanN6,N6-DimethyladenosinePhyllanthinDiosgeninTyr Leu ValProcaine(6Z,9Z)-Hexadecadienoylcarnitine2'-Deoxyadenosine1,2,4-NonadecanetriolRadarin B9,10-Dihydroxy-12,13-epoxyoctadecanoateNordihydrocapsaicinArlacel A3-(3,4-dihydroxyphenyl)propyl palmitateN-Eicosapentaenoyl LysineN2-Succinyl-L-arginineMycalamide BJuruenolide FLysoPC(P-18:0/0:0)4-Guanidino-1-butanolcarbidopa2-hydroxy-3-methylvalerate(+/-)-trans-Acenaphthene-1,2-diolLanyuamide I3beta-Acetoxy-12beta,13beta-epoxy-11alpha-hydroperoxyursane6-Acetyl-D-glucoseepsilon-L-norlysyl pyrralineColnelenic acidPutative (3-hydroxyheptadecanoyl)glycinePolydatinLyso-PAF C-184-(1-methyl-2-pyrrolidinyl)-3-oxobutanoateepi-Bisdehydroneotuberostemonine J3b-hydroxy-5-cholenoic acidHis-ProN-Acetyl-b-glucosaminylamineDiisopropanolamineN-Eicosapentaenoyl PhenylalanineChrysogedone BLithospermoside2-DeoxyglucoseXylitol6-O-(trans-4-coumaroyl)-alpha-D-glucopyranosechinese bittersweet alkaloid IITuberostemospironineOctyl-3,5-di-tert-butyl-4-hydroxyhydrocinnamateCetylmannosideCedrinoside4-Acetylimidazo[4,5-c]pyridineAlitameDisofenin4-Acetamido-5-[2-(4-hydroxyphenyl)ethylamino]-5-oxopentanoic acidCleroindicin DL-thyronineRiboflavinPro Gln HisAlnespironeLimoninLamiridosin AGutierrezianolic acid isobutyrate methyl ester4-Alanylaminoantipyrine24(28)-Dehydromakisterone AMefentanylLeuhistinTeuhircosideR-Palmitoyl-(2-methyl) EthanolamideCumeneH-gamma-Glu-Gln-OHN-Acetylaspartylglutamic acid (NAAG)MachilleneMultifideneRipromycinSM(d18:1/16:1(9Z))VedelianincytidineTsugaric acid AKukoamine B1,2-Dioctanoyl PCWallichoside (Pteris)Asterinic acid5beta-Cholestane-3alpha,7alpha,12alpha,24-tetrolGlyceryl linolenatePhyllaemblic acid BCreatinine lactate(2E,4E,12Z)-N-(2-methylpropyl)octadeca-2,4,12-trienamidenor-Spiculoic acid ADaphmacrineDendronesterol A6a,12a-DidehydroamorphigeninNordihydrocapsiateDianthin CThiochromeN-Methyl-4-pyridone-3-carboxamideDesoxyguanosine2-Pentyl-4-propylthiazolePentyloneClobazam(13Z,16Z)-Tetracosa-13,16-dienoylcarnitineGly Phe Val5-FormylbenzofuranBacithrocin B1SM(d19:0/PGF1alpha)Stearoylethanolamide2-Hydroxy-3-phenylpropenoate6H,8H-3,4-Dihydropyrimido(4,5-c)(1,2)oxazin-7-oneBlazeispirol BN-Palmitoyl Aspartic acidicosasphinganinebeta-AmyroneMethyl quadrangularate I7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate1-(D-3-Mercapto-2-methyl-1-oxopropyl)-L-prolineThr Leu3alpha-Hydroxy-3,5-dihydromonacolin L acid1-PyrrolidineethanolAranorosin6-cis-Docosenamide10-MethylHexadecanoylcarnitineN-Acetyl-S-methylcysteineMelophlin J2-(3'-(5'-Hydroxyindolyl)methyl)-1,3-thiazolidine-4-carboxylic acidMelophlin M(+)-Tubelactomicin AMelophlin OPA(i-13:0/20:4(6E,8Z,11Z,14Z)-OH(5S))ValylglutamineN-Isobutyl-(2E,4E)-octadecadienamideMelophlin PSachaloside V13-epi-12-oxo Phytodienoic Acid4-Ethyl-5-methyl-2-(1-methylethyl)thiazoleMelophlin DMelophlin FGolotimod2'-deoxy-5-(4,5-dihydroxypentyl)uridinePC(16:0/P-16:0)PE(14:0/14:0)N-MethylfuntumineSulpinine AMintsulfideHederacine BPhomoenamideFomlactone BPraziquantelRubrobramideChabrolobenzoquinone Agamma-GlutamylisoleucineEsprocarbCytochalasin AN-[(4E,8E)-1,3-dihydroxyoctadeca-4,8-dien-2-yl]hexadecanamide1-Acetyl-N-salicyloyl-2-aminopropan-3-olIle Thr Ilebenzyladenine-7-N-glucosideSachaconitineTetradecanoylcarnitineLysoPE(0:0/20:5(5Z,8Z,11Z,14Z,17Z))PC(16:0/O-1:0)Linichlorin APolyporusterone BPolyporusterone A(+)-Milnamide AS-Phenylmercapturic acidN,N-DimethylsphingosineAdiantoneHecogeninWentilactone BCytochalasin MArnidiolScilliglaucosidoneMaculosinalfuzosinJuncutolGlyinflanin AGlutaminylhydroxyproline(11Z)-8,18-methano-retinalbeta-MicropteroxanthinCespihypotin TCytochalasin TPrimapterinD-MannosamineTetradeca-2,4,6-trienoylcarnitineEicosanedioic acidVitamin B5ViridicatolDarutosideSakacin AEliprodil(+)-4,5-Didehydrojasmonic acidThiocyanatin CEquolHalaminol CThiocyanatin AMakisterone BAltertoxin III12-O-deacetyl-19-O-methyl-12-epi-deoxoscalarin4,4'-DiapolycopenedialAjugapyrin ADidesmethyl tocotrienolalpha-TocomonoenolSarkomycin DPiptamine(antibiotic)Leu Val Metepsilon-Maleimido-lysineAustralin ACytosporin DEmetine(2-((3,5-Di-t-butyl-4-hydroxyphenyl)thio)-1-methylpropoxy)acetic acidMacrosphelide BThiamine2'-Hydroxyfurano[2'',3'':4',3']chalconeTerretonin A4alpha-Formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-olLassiocarpineH-Leu-Glu-OHNeolindenenonelactoneOenanthic etherLagochilin3,6-DihydrochamazuleneIsoinundatineNADPhomonitroesterStolonoxide E3-Hydroxydihydroirisquinone6'-Hydroxy-3'-ketoveprisineLys Val Leu(-)-CycloepoxydonMontanolThioprolineCyclo(L-Pro-L-Val)IrgarolDasyrachineSerylvalylglycylglutamic acid5-HydroxymethylcytidineDelbine(3E,5Z,7Z,9E)-Trideca-3,5,7,9-tetraene2-glyceryl-Prostaglandin H2N-Jasmonoylisoleucinegamma-Glutamyltyrosine2-Oleoyl-sn-glycero-3-phosphocholineGlu Glu TrpDIBOAVelloquercetin 4'-methyl etherPiclamilastIoneneShiononeSpermidinePterolinus FPro Trp AlaN-Palmitoyl HistidineMiraxanthin-IIIRacloprideLysoPE(0:0/20:2(11Z,14Z))Hydroxytyrosol 3'-sulfateNardosinonePramiracetam13Z,16Z,19Z,22Z,25Z-octacosapentaenoic acidBeta-Hyodeoxycholic acidNorkurarinolcis-4,7,10,13,16,19-Docosahexaenoic acidCardanolideNephrosteranic acidCoronalolide methyl esterEryvarin CAspartylphenylalanineNoradrenochrome o-semiquinoneLeucyl-AlanineDeoxycholylasparagineHeteroplexisolide Ep-HydroxytriamtereneMyltaylorione BRadicamine ADiisononyl phthalateRadicamine BDivaricatic acid (Pteronia)ChrysandiolIsodoacetalGeranylgeranylcysteineHistidinyl-CysteinePC(17:1(10Z)/0:0)Asperorydine JAnthramycin methyl etherZearalenoneAnomalinJuglanoside A9-Octadecen-1-amineN-Arachidonoyl LysineLeiokinine A(-)-5'-DemethylyateinVal-pro-proGalanganol CLedolEpothilone H1Ritalinic acidH-Pro-Trp-OHlabd-13-en-8alpha-,15 diolDimebutic acidCavinine5-Methoxy-8-O-beta-D-glucosyloxy-psoralenEthyl 4-(acetylthio)butyrateDiprenorphine2,4-Diamino-6,7-diisopropylpteridineGlycyl-Proline11,12,15-THETAMethyl alpha-EleostearateSorbitan oleate(2E,6E,8E)-Dodeca-2,6,8-trienedioylcarnitinePC(18:1(11Z)/18:1(9Z))Oglufanide10-FormyldihydrofolateLeucyl-TyrosineTalaromycin A18:0 LYSO-PEOsmundalactonePalmitic amideSteviol12-Acetoxyeremophilene1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamideLeucine butyl esterTenofovirSpiromassaritone4-(3-Phosphonopropyl)piperazine-2-carboxylic acid1-Hydroxy-2-naphthoateHeptadecatrienalOchrocarpinone BPlagiochilin I(22E)-24nor-cholesta-1,4,22-trien-3-oneCyclo-(L-phenylalanine-D-4-hydroxyproline)Bis(2-methylundecan-2-yl) DisulfideMG(18:1(11Z)/0:0/0:0)Triton X 100D-Fructose-6-phosphate25-AzacholesterolTritoniopsin D17beta-Nitro-5alpha-androstane(8R)-3beta,8-dihydroxypolypoda-13E,17E,21-trieneLicoisoflavone BIle Leu LeuLeu-Leu-TyrTryptopholCephalotaxineVirgatyneFatsicarpain FL-LysineApo-8'-bixinal3beta,4alpha-Dihydroxy-13beta-methoxylupanine4-guanidinobutanoateMogroside I E1Humilinolide CProcaterolMethyl heptadecanoate(4E,6E)-3-hydroxydeca-4,6-dienoic acidCallyspongynic acid22:3(5Z,9Z,19Z)(13Me,17Me,21Me)N-(4-Coumaroyl)-L-homoserine lactoneHexadecasphinganine2-CarboxybenzaldehydeN-Docosahexaenoyl Arginine1-MethylhistidinePyridoxine 5'-phosphateHis Phe3-acetamino-6-isobutyl-2,5-dioxopiperazineNigerapyrone BSM(d18:1/16:0)(plusmn)13-Azaprostanoic acidgamma-Glutamylaspartic acidHydroxybuprenorphineRamiprilatKopsilonginePicramnioside DDysinosin DSporovexin CTetracosatetraenoic acid (24:4n-6)VanessineSporovexin BEglinazineGuanadrel11beta-HydroxycurvularinMDMA methylene homologMetoprololMG(0:0/21:0/0:0)Trp Lys ArgN-Palmitoyl ThreonineGlycochenodeoxycholic acid(11Z)-Docos-11-enoylcarnitine9-Oxo-10,12-octadecadienoic acidAsp Val PheBruceine H13(S)-HODETurbinatineMonooleinAKBA7,11,15-Trimethyl-3-methylene-1,2-hexadecanediol diacetateProgesteronerel-2alpha,3beta,23-trihydroxy-12,17-dien-28-norursaneN-Methyl-calystegine B2D-FructoseH-TYR-GLN-OHcis-11,14,17-Eicosatrienoic acidTFAPPrunetinPhe-Ala-AspLysine conjugated cholic acidN-acetylarginine4'-OxonebramineSuprofenThr Glu(8Z,11Z)-Henicosa-8,11-dienoylcarnitineDihydroalbocyclineN-AcetylprocainamideBergenincis-1,2-Dihydroxy-1,2-dihydro-8-carboxynaphthaleneThiamine monophosphatePicrotinAlloxydimPalmitoylethanolamide(Ethoxymethyl)benzenePentamidine(+)-(3R)-3-acetoxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptaneLeu-Asp-SerBuxifoliadine-DGibberellin A10Methyl 3,4-dihydro-5-methyl-8-isopropyl-2-naphthalenecarboxylateDidemnidine ABriarellin OLeu-Thr3beta-Hydroxy-15-[3-methylvaleryloxy]-ent-labda-7,13E-dienBriarellin NBriarellin LDihydroactinospectacinL-PyridosineOctahydrocurcumin3-HydroxyaminophenolNavarixinStellettin BDicraninRicinoleic acidSinapic acid ethyl esterCitrininEslicarbazepineAdenostin BFeruloylputrescinePhorbol 13-butanoateGeijeren24-MethylenepollinastanoneR-2 Methanandamide17-Hydroxycyclooctatin, (rel)-3,5,6-Trimethoxyfurano[2,3:7,8]flavoneAustalide H8-(2-Hydroxyethyl)theophyline10'-ApoviolaxanthalNicotine glucuronide5,10-Dihydroxyfurospinulosine 1Ala-Leu-Leu-SerDiethylenetriamine crosslinked with epichlorohydrinMicrosphaerone C_120103Prolyl-ArginineGlycidyl stearate7-OxodehydroasimilobineN-decanoyl-L-Homoserine lactonePenciclovirTrp Trp Lys2,6 dimethylheptanoyl carnitineN-Myristoyl AsparagineN1,N8-DiacetylspermidineVolkenin13-(3-Methyl-5-propylfuran-2-yl)tridecanoylcarnitineTerreulactone CN-methylanthraniloyl-beta-D-glucose3beta-Hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehydeAla-Ala-Pro-ProFarnesylcysteineAndrachcinidineGnidilatidinPA(a-13:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4))Luotonin CBerbamineVirginiamycin M1N-Arachidonoyl AsparagineGlochidoneEpoxycytochalasin HDankasterone BGibberellin A38Butyl oleateDinor-PGD2Aikupikanyne B3-Keto-24-epi-7,8-didehydrocimigenolPhe Ile GlnEtomoxirBisacuroneseco-plakortolide KPonasterone ASanjoinine G2ladaneinGlu-Ile-ValDrofeninePC(20:0/P-16:0)OmaezakianolLeu-Thr-AlaBroussonetinine BDehydroepiandrosterone4alpha-Methylzymosterol-4-carboxylateMaoecrystal BCrocetinDendronesterone CLysoPC(18:2(9Z,12Z)/0:0)4-[3-(4,8-Dimethyl-3,7-nonadienyl)-3-methyloxiranyl]-2-butanone3-HydroxymonoethylglycinexylidideRadulifolin BLinamarinCodonocarpineStemaphylline N-oxideDurumhemiketalolide AAbietane2,6-Pyridinedicarboxylic acidL-ArginineStrophanthidingamma-Linolenic acid8-(2-hydroxy-3-methoxy-3-methylbutyl)-7-methoxychromen-2-oneBroussoflavan Aalpha-Linolenic acidCyclo(Ala-Gly)3beta-Acetoxy-8beta,15-dihydroxy-ent-labda-13E-eneFormylkynurenine4-Bis(2-hydroxyethyl)amino-L-phenylalanineCoetsanoic acidAglacin AMoracin LDocosahexaenoyl EthanolamideArg Leu IleDehydroeburicoic acid monoacetateGinkgolic Acid (C13:0)MethocarbamolPseudolaric acid AXerophilusin VLinoleylanilideN-Succinyl-L,L-2,6-diaminopimelateN6,N6,N6-Trimethyl-L-lysineImidazole acetol-phosphateGalactitol 1-phosphateKhrinone D6-Acetyl-1,2,3,4-tetrahydropyridineSpiradine BBengamide E2-palmitoleoyl-glycerolWithaphysalin N3-Amino-2-oxazolidinone17alpha-Methyltestosterone9(S)-HOTCapsi-amide2-Hydroxy-3-(1H-imidazol-5-yl)propanoic acidN-Pyruvoyl-5-methoxy-3-hydroxyanthranilateD-ProlineHis Ile Asn6alpha-HydroxycampestanolLeucosesterterpenoneLeu-Gln-ProN-Stearoyl LeucineAnthosterone B(9Z)-Icos-9-enoylcarnitineTropanserin1-NaphthylacetylspermineTriclisineLumichromeBesarhanamide B9,10,18-TrihydroxystearateVal Ile LeuN,N,O-Tridesmethylvenlafaxine4-Coumaroyl-2-hydroxyputrescineBesarhanamide AH-Pro-Leu-OHDiprotin AEpoxy (4,5Alpha)-4,5-DihydrosantoninLeopersin NArachidonoyl-carnitine5-Ketomilbemycin A3Dictysine4-(Dimethylamino)butyl carbamimidothioatePulcherrin A24(S),25-EpoxycholesterolAnserineIle Leu Thrp-hydroxybenzoyl glucose3,N(4)-Ethenodeoxycytidine(2R)-2-[(2R,5S)-5-[(2S)-2-hydroxybutyl]oxolan-2-yl]propanoic acidIndospicine10-HydroxymelleolideH-Val-Met-OHFingolimod phosphate ester, S-AlliinFlibanserin(S)-Piperidine-2-carboxamideN-AcetylprolineRhodotulic acidHydroxypropionylcarnitine2,4-Dimethyl-5-vinylthiazoleLeupeptin analogue LVRDioxolamycinCytidine 2'-phosphateacetyl-d-carnitine16-Butyl-3-methoxy-estra-1,3,5(10)-triene-16beta,17beta-diolhomoargininePristimerineN-Oleoyl ArginineDeoxygaudichaudione AProlyl-Gamma-glutamateSphinganine 1-phosphateL-Valyl-L-phenylalanineMethyl dihydrojasmonateL-SelenoMethionineTaiwaniasterol DBis(agmatine)oxalamideObscuraminol AMyrothenone A(-)-N-Methylhigenamine N-oxideHymenoside SVictoxinineGlu LeuTetrahydrocytisine2,6,10,14-Tetramethyl-6,10,15-hexadecatriene-2,3,8,14-tetrol 8-acetateCallyspongenol ATashironinIsoalbrassitriolSM(d18:1/12:0)Certonardosterol A2(-)-Chrysogine14-AcetyltalatizamineSarcaglaboside D(E,E)-Terrestribisamidear-TurmeroneSargaolLeucylleucine methyl esterPalmitoleoyl EthanolamideChabrolohydroxybenzoquinone F2-Oxoarginine1,4-DiphenethylpiperazineO-dodecanedioylcarnitineN-acetylsphingosine17-(1h-Imidazol-1-yl)androsta-4,16-diene-3-oneEstradiol-17-phenylpropionate4-Amino-3-hydroxybutanoylcarnitineIsopropalinNeryl glucosideGlanvillic acid AGlycycoumarinDG(i-19:0/20:4(6E,8Z,11Z,13E)-2OH(5S,15S)/0:0)Musk ambretteFiciolide J4-(7H-Purin-6-ylsulfanyl)but-3-en-2-oneAntibiotic UK 2DAnisatinAspidoalbineGama-glutamylalanineSphingosine (d17:1)p-Lactophenetide20-hydroxy-fusarinErgosta-4,22-dien-3-oneDesacetyllevonantradolCucumopinePA(20:3(5Z,8Z,11Z)/18:1(9Z)-O(12,13))Trideca-5,7,9-trienoylcarnitineHydroxyprolyl-HistidineLimazepine ACostunolideLysoPA(0:0/18:0)Isopropyl-beta-D-thiogalactopyranosideLimazepine CPSEUDO-ANISATINArieianalNitrosylsulfuric acidDG(PGD1/0:0/i-19:0)17beta-Hydroxyestr-4-en-3-one cyclopentanepropionateMicrandrol ALaureacetal E3-Hydroxyhept-4-enoylcarnitineGlycylprolylarginineDeoxycorticosterone acetate(S)-alapyridaineN-acetylphenylalanineMenatetrenone EpoxideChloranthalactone CAustrobuxusin IN-(N-(3-Carboxyoxirane-2-carbonyl)leucyl)isoamylamine24-methylene-19-norcholesta-1,3,5(10)-trien-3-olIle Pro Valgamma-Glutamyldopaglutamyl-meso-diaminopimelateMalekulatineOxypurinolDihydroornativolideEthyl oleateAsmarine Icis-3-Hydroxy-l-prolineL-BaikiainADAPALENENortetillapyroneMicropinedelta-8(9),22-Ergostadiene-3beta-olSarcrassin CIsalexinDihydrotanshinone I5'-deoxyinosine(+)-Terpendole APTERIN1-MethylcytosinePalau'imide3-Methylcytidine1,3-DimethyluracilTyromycin ASmenospongine CErgosta-8,14,24(28)-trien-3beta-olNigellidineTriphenyl phosphateAsp-ValSphingofungin BSalicyluric acidLeu-Val-GlyFeselolGln Leu LeuDihydroajaconineAcebutolol3,6-DihydroxydecanoylcarnitinePapyriogenin A4-HADNT O-glucosideDG(a-17:0/5-iso PGF2VI/0:0)Sarcotol acetateGanoderic acid DMCarbacholValylprolinePepstatinBarbatolN-Docosahexaenoyl MethionineHomoarbutinAsiaticosideArg Ile IleAsn-Leu-Leu-SerfalseBupleurum chinense DC polysaccharides ameliorate DSS-induced ulcerative colitis by regulating gut microbiota and tryptophan metabolism via NF-κB pathway<p>Background: Bupleurum chinense DC polysaccharide (BCP) demonstrates a significant role in ameliorating gastric ulceration and enhancing intestinal barrier function, and have broad medicinal value. Nevertheless, the therapeutic effects and mechanisms in ulcerative colitis (UC) remain to be elucidated.&nbsp;</p><p>Purpose: The protective effect of BCP on dextran sulfate sodium (DSS)-induced UC and the related mechanisms will be discussed.</p><p>Methods: The efficacy of BCP was evaluated using a 2.5% DSS-induced UC model. The mechanistic contribution of the gut microbiota to the therapeutic efficacy of BCP in UC was elucidated through 16S rRNA sequencing, microbiota depletion experiment and fecal microbiota transplantation (FMT) experiments. Non-targeted metabolomics analysis was used to identify its potential metabolic pathways and core signaling pathways. In vitro, Caco-2 and NCM460 cells were treated with LPS to induce inflammation for assessing the effects of BCP.</p><p>Results: BCP significantly alleviated UC injuries, including decreasing body weight loss and disease activity index (DAI), and increasing colon length. Moreover, BCP significantly reduced inflammatory cytokine levels and improved histopathological damage in the colon. BCP promoted tight junction proteins (TJ proteins) expression, facilitated MUC2 secretion, and helped alleviate DSS-induced intestinal barrier damage. BCP could improve the gut microbiota changes, and BCP’s therapeutic effects on UC were mediated through the gut microbiota in vivo experiment. Additionally, metabolomics analysis revealed that BCP could impact the tryptophan metabolism pathway and target the AHR-NF-κB signaling pathway to improve UC.</p><p>Conclusion: This study reveals that BCP improves UC through modulation of the gut microbiota and the tryptophan metabolism via NF-κB axis.</p>2026-02-012026-02-01MTBLS13814HMDB0000715HMDB0252237HMDB0001254HMDB0000402HMDB0001409HMDB0062175HMDB0250801HMDB0003903HMDB0002520HMDB0030254HMDB0035159HMDB0002327HMDB0000795HMDB0060760HMDB0246466HMDB0000381HMDB0000254HMDB0247093HMDB0003553HMDB0000888HMDB0029660HMDB0029041HMDB0000497HMDB0000905HMDB0005785HMDB0004629HMDB0000127HMDB0000296HMDB0013674HMDB0000263HMDB0000133HMDB0005896HMDB0000645HMDB0001248HMDB0010325HMDB0001227HMDB0000175HMDB0001321HMDB0240209HMDB0000606HMDB0000251HMDB0254174HMDB0253212HMDB0033615HMDB0003259HMDB0036651HMDB0000933HMDB0040594HMDB0061925HMDB0013034HMDB0302664HMDB0036671HMDB0246575HMDB0033153HMDB0034649HMDB0041008HMDB0034517HMDB0030636HMDB0031864HMDB0040937HMDB0011725HMDB0031009HMDB0029249HMDB0034551HMDB0254175HMDB0029140HMDB0034251HMDB0028686HMDB0028853HMDB0000328HMDB0000502HMDB0000364HMDB0002639HMDB0000806HMDB0304816HMDB0002080HMDB0001999HMDB0002226HMDB0005048HMDB0061706HMDB0000893HMDB0000943HMDB0000661HMDB0000019HMDB0000695HMDB0000754HMDB0001987HMDB0003070HMDB0002107HMDB0001844HMDB0000044HMDB0000375HMDB0062549HMDB0011756HMDB0011745HMDB0000932HMDB0000828HMDB0011732HMDB0034367HMDB0006028HMDB0001964HMDB0006528HMDB0249369HMDB0000012HMDB0000884HMDB0000195HMDB0000767HMDB0002275HMDB0003503HMDB0246401HMDB0000623HMDB0004813HMDB0001859HMDB0004077HMDB0000672HMDB0031057HMDB0246588HMDB0001563HMDB0028854HMDB0028942HMDB0011733HMDB0005923HMDB0001397HMDB0029737HMDB0000755HMDB0006116HMDB0000230HMDB0002259HMDB0001043HMDB0000881HMDB0000746HMDB0000975HMDB0000247HMDB0000208HMDB0003072HMDB0000792HMDB0000422HMDB0000784HMDB0028929HMDB0001138HMDB0000273HMDB0000866HMDB0304947HMDB0000626HMDB0000619HMDB0000826HMDB0002925HMDB0000951HMDB0000245HMDB0000156HMDB0000205HMDB0000857HMDB0000158HMDB0000812HMDB0000639HMDB0000214HMDB0000094HMDB0000722HMDB0000653HMDB0034228HMDB0001991HMDB0002053HMDB0000444HMDB0001983HMDB0011178HMDB0030351HMDB0038549HMDB0031154HMDB0002388HMDB0006242HMDB0002212HMDB0000592HMDB0062295HMDB0037588HMDB0038990HMDB0250176HMDB0001016HMDB0062320HMDB0253474HMDB0002504HMDB0009055HMDB0245010HMDB0033630HMDB0243788HMDB0038304HMDB0041997HMDB0301795HMDB0036018HMDB0240603HMDB0303271HMDB0062318HMDB0030360HMDB0114750HMDB0240595HMDB0001090HMDB0125171HMDB0035599HMDB0040822HMDB0011514HMDB0253672HMDB0011472HMDB0059996HMDB0241934HMDB0114753HMDB0041565HMDB0060719HMDB0011142HMDB0038657HMDB0033675HMDB0247624HMDB0033690HMDB0060051HMDB0036763HMDB0036760HMDB0041126HMDB0004821HMDB0010604HMDB0000385HMDB0011653HMDB0060664HMDB0036701HMDB0000963HMDB0032784HMDB0112075HMDB0032102HMDB0033899HMDB0249242HMDB0242239HMDB0114762HMDB0011721HMDB0244863HMDB0012228HMDB0010573HMDB0245688HMDB0060648HMDB0059592HMDB0062322HMDB0040243HMDB0252021HMDB0061681HMDB0034406HMDB0015467HMDB0035200HMDB0251084HMDB0251557HMDB0061698HMDB0059928HMDB0240599HMDB0240594HMDB0030020HMDB0240605HMDB0036749HMDB0247584HMDB0038683HMDB0036812HMDB0031080HMDB0248837HMDB0008889HMDB0001094HMDB0039867HMDB0036895HMDB0251961HMDB0011470HMDB0039148HMDB0000340HMDB0011154HMDB0304284HMDB0002163HMDB0003069HMDB0247011HMDB0000394HMDB0248250HMDB0041037HMDB0061645HMDB0248927HMDB0032783HMDB0030044HMDB0015579HMDB0245853HMDB0007004HMDB0245653HMDB0248306HMDB0060791HMDB0015359HMDB0010348HMDB0030065HMDB0061711HMDB0030015HMDB0038532HMDB0244149HMDB0244800HMDB0006752HMDB0041110HMDB0039043HMDB0062323HMDB0062288HMDB0005076HMDB0249633HMDB0001488HMDB0033723HMDB0059601HMDB0031031HMDB0000982HMDB0001202HMDB0000299HMDB0000289HMDB0060015HMDB0006101HMDB0244355HMDB0012535HMDB0000782HMDB0059933HMDB0000017HMDB0000157HMDB0014797HMDB0000292HMDB0011507HMDB0062794HMDB0037851HMDB0004710HMDB0037798HMDB0032857HMDB0155722HMDB0301821HMDB0035751HMDB0036857HMDB0302281HMDB0015302HMDB0304157HMDB0036790HMDB0000350HMDB0301824HMDB0000072HMDB0304342HMDB0013272HMDB0002982HMDB0000912HMDB0011477HMDB0249891HMDB0062664HMDB0303141HMDB0000872HMDB0240316HMDB0304125HMDB0001180HMDB0013286HMDB0014697HMDB0001520HMDB0059632HMDB0005032HMDB0062618HMDB0031019HMDB0002261HMDB0250930HMDB0246398HMDB0259399HMDB0000601HMDB0039691HMDB0247015HMDB0037941HMDB0247056HMDB0001877HMDB0004049HMDB0014443HMDB0250352HMDB0250129HMDB0244280HMDB0000529HMDB0000735HMDB0013279HMDB0032121HMDB0304111HMDB0254869HMDB0002823HMDB0002250HMDB0240756HMDB0241967HMDB0034079HMDB0004256HMDB0303140HMDB0012283HMDB0036859HMDB0038685HMDB0004704HMDB0014583HMDB0040867HMDB0014629HMDB0029200HMDB0303447HMDB0248832HMDB0060080HMDB0240588HMDB0013219HMDB0240762HMDB0013333HMDB0000279HMDB0062720HMDB0249689HMDB0249529HMDB0004083HMDB0010575HMDB0002658HMDB0028994HMDB0000220HMDB0001367HMDB0006202HMDB0249229HMDB0003559HMDB0246678HMDB0254177HMDB0033691HMDB0003459HMDB0250365HMDB0029073HMDB0258206HMDB0014904HMDB0014944HMDB0245964HMDB0011518HMDB0256912HMDB0002776HMDB0301858HMDB0011530HMDB0302128HMDB0012559HMDB0028848HMDB0246143HMDB0060180HMDB0245535HMDB0030801HMDB0255025HMDB0304437HMDB0249427HMDB0061666HMDB0035959HMDB0029438HMDB0062399HMDB0248569HMDB0256070HMDB0253800HMDB0259271HMDB0252462HMDB0015413HMDB0029139HMDB0030180HMDB0015074HMDB0000855HMDB0001565HMDB0001058HMDB0014513HMDB0001491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