MetaboLights

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(peaks) with a missing rate >50% across all sample groups were filtered out. Remaining missing values were imputed using a two-step method: if the proportion of missing values for a feature was >50%, values were filled with 1/5 of the minimum positive value; otherwise, k-nearest neighbors (KNN) imputation was applied. Peak areas were then corrected using Support Vector Regression (SVR). Metabolite identification was performed by matching the corrected features against a combination of an in-house laboratory database, integrated public databases, and predictive libraries.MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phaseThe chromatographic separation was performed on a Waters ACQUITY UPLC system equipped with an ACQUITY Premier HSS T3 column (1.8 µm, 2.1 mm × 100 mm; Waters, USA). The mobile phase consisted of (A) 0.1% formic acid in water and (B) 0.1% formic acid in acetonitrile. The gradient elution program was set as follows: 0–1.0 min, 95% A; 1.0–3.0 min, 80% A to 1% A; 3.0–4.5 min, held at 1% A; 4.5–4.6 min, changed to 95% A; and 4.6–6.0 min, held at 95% A for column re-equilibration. The column temperature was maintained at 40°C, the flow rate was 0.4 mL/min, and the injection volume was 4 µL.Exploring the Effects of Different Exercise Modalities on Skeletal Muscle Function in High-Fat Diet-Induced Obese Mice Based on Gut Microbiota and Metabolomics.Yefan WangShanxi Universityblood serummass spectrometry assayFor liquid serum samples, a standardized solvent extraction protocol was employed. Briefly, frozen serum samples stored at -80°C were thawed on ice. After vortexing, a 50 µL aliquot of each sample was transferred to a pre-labeled tube. Metabolites were then extracted by adding 300 µL of ice-cold 20% acetonitrile in methanol containing internal standards. The mixture was vortexed for 3 minutes and centrifuged at 12,000 rpm for 10 minutes at 4°C. The supernatant (200 µL) was transferred to a new tube, held at -20°C for 30 minutes, and centrifuged again at 12,000 rpm for 3 minutes at 4°C. Finally, 180 µL of the clarified supernatant was transferred to an autosampler vial for LC-MS analysis. Quality control (QC) samples were prepared by pooling equal aliquots from all individual samples and were processed identically alongside the experimental samples throughout the entire extraction procedure.Mus musculushttps://www.ebi.ac.uk/metabolights/MTBLS13878Lijun Wu. Shanxi University. Wlj666888@126.com.Yefan Wang. Shanxi University. 1321274002@qq.com.Raw mass spectrometry data were converted from vendor format to mzML format using ProteoWizard software. Subsequent data processing, including peak picking, alignment, and retention time correction, was performed using the XCMS program.Group1321274002@qq.comBlood samples were collected from the retro-orbital venous plexus of male C57BL/6 mice. After collection, the whole blood was allowed to clot at room temperature for 30 minutes. The serum was then separated by centrifugation at 3,000 rpm for 10 minutes at 4°C. The resulting supernatant (serum) was carefully aliquoted into sterile tubes and immediately stored at -80°C until further metabolomic analysis.MetabolomicsMetabolomicsHigh-Fat Diet-Induced ObesityGut MicrobiotaSkeletal Muscle FunctionExercise InterventionMetabolomicsHigh-Fat Diet-Induced ObesityGut MicrobiotaSkeletal Muscle FunctionExercise InterventionMass spectrometric analysis was performed on a Q Exactive HF-X hybrid quadrupole-Orbitrap mass spectrometer (Thermo Fisher Scientific, USA) equipped with an electrospray ionization (ESI) source. Data were acquired in both positive (ESI+) and negative (ESI-) ionization modes. The detailed operating parameters were set as follows: spray voltage, 3500 V for ESI+ and 3200 V for ESI-; sheath gas flow rate, 30 arbitrary units (Arb); auxiliary gas flow rate, 5 Arb; ion transfer tube temperature, 320 °C; vaporizer temperature, 300 °C. Full MS scans were acquired over a mass range of m/z 75–1000 with a resolution of 35,000. The automatic gain control (AGC) target for MS1 was set to 1e6. Data-dependent MS/MS acquisition (Top N = 10) was performed with a resolution of 17,500 (AGC target: 2e5) using stepped normalized collision energies (NCE) of 30, 40, and 50 V. The dynamic exclusion time was set to 3 seconds.Diethyl hydrogen phosphateDL-2-Aminooctanoic acidCorticosterone2,3-DihydrothienamycinAcetoxyacetone(9Z)-heptadeca-1,9-dien-4,6-diyne-3,8-dionegamma-Aminobutyric acidDihydrodaidzein2-Butyne-1,4-diolMethyl nicotinatePropyl 1-(propylsulfinyl)propyl disulfideAmidosulfonic acidAltretamineL-HistidineL-AllothreonineMethyl geranate1,2-Dilinoleoyl-SN-glycero-3-phosphocholineBifenazateIminodiacetic acidNipecotic acid1-Octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)LPC(18:1/0:0)CitrullineScopoletin1,5-NaphthalenediamineN-Ethylglycine2,3-Dimethoxyphenol11beta-PGE2N-Acetyl-D-tryptophan4-AminoazobenzenePicolinamide1-Undecanol1-(1Z-octadecenyl)-sn-glycero-3-phosphocholine2,5-Dimethyl-2,4-hexadiene3,4-Dihydroxymandelic acidRicinine(3S)-2-oxo-3-phenylbutyric acidN1-acetylspermine1-AcetylisatinL-Theanine4,4'-SulfonyldiphenolClavamycin Balpha-ErgocryptineFexofenadine5-(4-Piperidyl)isoxazol-3-olCaffeic acidIsophorone4-Methyl-5-thiazoleethanolProline betaineOleamideCinnamic AcidLidocainePantothenic acidColfosceril palmitateDehydroevodiamine1-Benzylimidazole1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine6-Benzylaminopurine6-keto-PGF1¦ÁTetraethylammonium7-KetocholesterolDrostanolone propionateBenzocaine2-Methyl-4-pentenoic acidMetaproterenolIndoleacetaldehydedelta-Hexanolactone3-NitrophenylhydrazineAmitroleSulcotrionePhenylephrine13-DocosenamideCarnitine C18:1Phe-Glutrans-2-Octenoic acidProstaglandin D1Benzyl alcohol4beta-HydroxycholesterolDisopyramide phosphate7,8,4'-TrihydroxyisoflavonePyridine3-Phenyl-4-pentenal3-Methacrylic acid4-Oxoniocarbonylbenzoate¦Ä-Valerolactam3'-Adenylic acid2-Phenylglycine3-(2-Hydroxyphenyl)oxirane-2-carbaldehydeAndrostenedioneOrnithineNorambreinolideNormirtazapine4-Hydroxy-4-(3-hydroxy-1-butenyl)-3,5,5-trimethyl-2-cyclohexen-1-oneAsn-ValIndoleCysteamineN-(1-Deoxy-1-fructosyl)valine4-HydroxycyclophosphamideDL-ArginineNeryl formate2-Aminoethyl diphenylborinateGlucuronic AcidDL-3,4-Dihydroxyphenyl glycolL-CarnitineDesmethylsildenafilTagatoseo-CresolMethazolamideAdenosineDihydroactinidiolideAllopurinolL-prolinylglycine zwitterionCyasterone2-Hydroxycinnamic acidPC(16:0/2:0)Metepa1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamideChlorphenesinBenzoic acidMelatoninAscorbic acidThiodiglycolPhenforminErythritolprostaglandin A23-DehydrosphinganinePyrazin-2-carboxylic acidCarnitine C3:0Carnitine C9:1-OHN-Acetyl-L-tyrosineCarbendazimHexylresorcinolQuinonePhenol, 2-((ethylsulfonyl)methyl)-, methylcarbamateValeric acidTyrosine methylester1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-D-myo-inositol3-HydroxypropanalFlucytosineVildagliptin1-Oleoyl-2-myristoyl-sn-glycero-3-phosphocholineGeranyl acetateUmbelliferoneLys-AspPterosin N4-Hydroxy-3-methoxycinnamaldehyde1-MethylnicotinamideDehydrocostus lactone2-(1-methyl-1H-imidazol-5-yl)acetic acid5-Phenyl-1,3-oxazinane-2,4-dionecis-4-Octenedioic acid3-methoxybenzene-1,2-diolGlu-ValXanthosine2,3-di(tetradecanoyloxy)propyl hexadecanoateCitraconic anhydride¦Â-Alanine1-Eicosanoyl-sn-glycero-3-phosphocholineRimantadineN-Acetyl-L-arginineDocosanamide9-AminoacridineLycomarasmine1-nitrosonaphthalene(2R)-piperidin-1-ium-2-carboxylatePipecolic acidPC(18:1(11Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))Dazomet(8R,9R,10R,13S,14R,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-oneMirtazapineProstaglandin F2betaIndole-3-carboxaldehydeFlavin adenine dinucleotide2-[Hydroxy-(3-octadecanoyloxy-2-octadec-9-enoyloxypropoxy)phosphoryl]oxyethyl-trimethylazaniumDL-Ornithine2,5,8,11-Tetraoxatridecan-13-ol[2,3-Dihydroxypropyl(2-hydroxyethyl)amino]phosphonic acid2,3,4,5-Tetrahydroxypentanoic acidPC(15:0/20:5(5Z,8Z,11Z,14Z,17Z))HydroquinoneBisphenol AL-methionyl-L-threonine4-Fluoro-L-phenylalanine2-Amino-4-nitrophenol2-Methyl-1-pyrrolineNoralfentanilDifurfuryl disulfide5-MethoxyindoleacetateL-TryptophanamideDehydrochorismic acid7alpha-HydroxycholesterolPhenylethyl primeverosideEthyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylateBenz[a]acridineChloroformCarbimazole13,16,19-Docosatrienoic acid1,5-Dihydroriboflavin5alpha-Androstane-3alpha,17beta-diol3-Oxopentanoic acidOfloxacin1,4-Dithiane-2,5-diolDiethyl maleateDL-Leucine(4E,6E)-1-(4-hydroxyphenyl)-7-phenylhepta-4,6-dien-3-oneBenzyl glycinateMethyl dioxindole-3-acetateMesalazine1H-BenzotriazoleMG(16:0/0:0/0:0)Procaterol hydrochloride hemihydrateN-PalmitoylglycineTaurineProxanTrans-Zeatin3-Buten-1-ol2-HydroxybenzaldehydeLithocholic acidPramipexole1,2-Dierucoyl-sn-glycero-3-phosphocholine2-AminophenolIndole 3-Ethanol(-)-alpha-Terpineol4-AminophenolTrigonelline(E)-1-Propenyl 1-(propylthio)propyl disulfideL-Asparagine, N-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-LPC(16:1/0:0)3-Methyl-2,5-dihydrothiophene 1,1-dioxide17alpha-Hydroxypregnenolone3-Azaniumyl-4-[(1-methoxy-1-oxo-3-phenylpropan-2-yl)amino]-4-oxobutanoateGanoderic acid AIsobavachalconeVitamin e succinate4-Aminoisoxazolidin-3-oneAminoethoxyacetic acidTetramethylsilane(3S,4R)-3,4,5-trihydroxy-2-keto-valeric acid(-)-Bornyl acetateGeranylgeranioltrans-Aconitic acidp-AnisidineL-Palmitoylcarnitine(4S)-4-[(2E,4Z)-2,4-Decadienoyloxy]-4-(trimethylammonio)butanoate2,5-Dihydroxycinnamic acidmethylcarbamyl PAFDiammonium ethylenebis(dithiocarbamate)7-MethoxycoumarinGossypetin 8-glucuronide 3-sulfateQuinaldic acidL-methionine sulfoxideRebaudioside CMethyl 10-undecenoateOctopamineBenzidineL-TryptophanIsopropamideCarnitine C6:0SyringaldehydeN,N,N-Trimethyl-HistidineLPC(15:0/0:0)FFA(12:1)DopamineOxoamidealpha-Fluoro-beta-ureidopropionic acidgamma-Tocopherolxi-5-DodecanolidePyrazinamideDiosphenolCholesterol(1S,2R)-3-Methylcyclohexa-3,5-diene-1,2-diolNifedipineTestosteroneMorpholineAntimony trioxide2,6-DiisocyanatotolueneL-Cysteinesulfinic acidMyosmineAmprenavirTG(18:3(9Z,12Z,15Z)/20:5(5Z,8Z,11Z,14Z,17Z)/20:5(5Z,8Z,11Z,14Z,17Z))N-oleoylglycine2,4-Hexadienoic acidAlanylarginine3-methyl-3H-imidazo[4,5-f]quinolin-2-amineN-Acetylaminooctanoic acidCreatineSphingosine 1-phosphateN-(2-Hydroxyethyl)nicotinamideLPC(0:0/22:4)2,6-Dimethoxy-4-propylphenolOxiglutatione3-Nitroacrylic acidCytosineSteviobiosidealpha-Ionone12-Ketolithocholic acid2-Acetyl-1,4,5,6-tetrahydropyridine1-(4-Methoxyphenyl)-4-methylpentan-3-ol3-(6-Hydroxyindol-3-yl)lactic acid2-[(4-Methoxy-1-benzouran-5-carbonyl)amino]acetic acidHydroxyquinolineLPC(0:0/22:5)Acetylvalerenolic acidLysylprolineAcetohydroxamic AcidAngiotensin I/II (5-8)SelenomethionineN-Methyl-a-aminoisobutyric acid2-Methyl-4-(1H-purin-6-ylamino)butan-1-ol1-Hydroxyoct-2-enoylglycineHydroxyurea3-Hydroxypicolinic acidMiglustatn-Isopropylbenzenesulfonamide3-Aminoisobutanoic acid4-(Methylsulfanyl)butan-2-ol1-Phenylethanol4-Methylpent-2-enalVaccinosidePhensuximideL-Homocystine6-Methyl-5-hepten-2-one1,2,4-Benzenetriol4-Methyl-1-phenyl-2-pentanol4-Hydroxy-l-tryptophan2-Octanamidoacetic acidN-decanoylglycineCyromazineLPE(16:1/0:0)DimethylglycineGlutaminetetrahydrozolineN-Acetyl-L-phenylalanine5-Aminoimidazole-4-carboxamideCitpressine I14,15-Leukotriene C4(ExC4)1-(Ammoniomethyl)cycloheaxaneacetateBardoxolone1-hexadecanoyl-2-[(Z)-octadec-9-enoyl]-sn-glycerol 3-(2-aminoethylphosphonate)1,2,4-TrimethylbenzeneBicineDimethyl fumarate3-Amino-2-oxazolidoneAmantadine hydrochloride4-Oxo-4-(pyridin-3-yl)butanal1,2,3,4,5-BenzenepentolTyraminePropionic acidD-Kynurenine1,4,5,6-Tetrahydro-6-oxonicotinic acidL-ribulose12-Hydroxydodecanoic acidBilirubin (E-E)Gly-ValDeanol2-Hydroxy-2-methylpropanalMelezitose2-Acetylpyrrole3-Hexenedioic acid1-Chloro-2-methylpropene(1R,4R,5R)-2-methyl-5-[(2S)-6-methylhept-5-en-2-yl]cyclohex-2-ene-1,4-diol2-Azaniumyl-2-methylpropanoate1-NaphthylhydroxylamineMelanostatin2-(2,4-dihydroxyphenyl)-3-(3,7-dimethylocta-2,6-dien-1-yl)-5-hydroxy-8-(hydroxymethyl)-8-methyl-4H,8H-pyrano[3,2-g]chromen-4-one2',3'-DideoxyinosineN'-nitrosonornicotineIndoleacetic acidIsovaleramide3-Methylpentan-3-olResolvin E1DeisopropylhydroxyatrazineHydroxyphenyllactic acidRhodinyl propionateN-LactoylisoleucineMeprobamate7-Ethyl-10-(4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecinCholineCotinine methonium ionPC(8:0/8:0)Asparagine2,3-DihydrobenzofuranTromethamine4,4'-MethylenedianilineTrp-Pro5alpha-Androstane-3beta,17beta-diolTyrphostin 23Nicotinic acidDimethylurea5-HydroxymethyluracilDL-MethionineL-Isoleucine2-(((2-Ethylhexyl)oxy)carbonyl)benzoic acidL-alpha-Aminobutyric acidtrans, trans-3,5-Octadien-2-one(2-(1-Butoxyethoxy)ethyl)benzene4-Amino-3-hydroxybutyrateNovaluron2-Ethyl-4-hydroxy-5-methyl-3(2H)-furanoneSedoheptulose 7-phosphate(2-)2-Furoic acidGlycyl-L-leucine1-Methylpyrrolinium4-MethylthiobutanaldoximeSolasodine4-NitrocatecholIsonicotinamide2'-Deoxyadenosine5-Bromo-3-fluoro-1-methylpyridin-2(1H)-oneSibutramineOxadixyl6-Methyl mercaptopurine4-Hydroxyphenylpyruvic acidVal-GlnClonidineEpsilon-caprolactamGuvacinePiperidineD-OrnithineL-2-Aminoadipic acidTilarginine2-amino-4-({1-[(carboxymethyl)-C-hydroxycarbonimidoyl]-2-({4-hydroxy-6-[3-(4-hydroxyphenyl)-3-oxoprop-1-en-1-yl]-5-methoxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-3-yl}sulfanyl)ethyl}-C-hydroxycarbonimidoyl)butanoic acid1,4-NaphthoquinoneSpermidic acidDL-Glutamine3-Guanidinopropionic acid1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalenePhosphocholine1-o-Hexadecyl-2-oleoyl-sn-glycero-3-phosphocholineHymecromoneGlycyl-L-phenylalanine2-Hydroxy-1,4-benzoquinoneEnantio-PAF C-16Mechlorethamine1,2-Distearoyl-sn-glycero-3-phosphocholine2-Methyl-4-phenylbutyraldehydeN-Isovaleroylglycine3,3-Dimethylglutaric acid2-Hydroxy-2-methylbutanenitrileStearoylcarnitine(4-Hydroxy-3-methoxyphenyl)ethanolQuinolineSemidehydroascorbic acidAspartylysine2-Methyl-1-methylthio-2-butene1-O-Hexadecyl-2-arachidonoyl-sn-glycero-3-phosphocholine6-Hydroxyhexanoic acidArecolineL-Proline1,2-Didecanoyl-sn-glycero-3-phosphocholinePhenol1-Methyl-4-nitroimidazoleLPC(0:0/18:3)Aminosalicylic Acid3-Hydroxyanthranilic acidPE(P-16:0/20:3(8Z,11Z,14Z))[2-hydroxy-3-[(9Z,12Z)-octadeca-9,12-dienoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate5-Hydroxyindoleacetic acidGlucosamineDicyclohexylamine4-(3-Acetamidopropylamino)butanoic acid1,2,3-TrihydroxybenzenePiperidine acidm-Chlorobenzoic acidGlycine2-Hydroxyquinoline2H-Pyran-2-one, tetrahydro-4-hydroxy-4-methyl-, (R)-1-(1-Ethoxyethoxy)pentane1-PiperidinecarboxaldehydeMoupinamideMelamineexo,exo-1,8-Epoxy-p-menthane-2,6-diolMiglitolDimethyl tetrasulfide5-Hydroxytryptopholh-gamma-Glu-leu-ohDL-Pantothenic acidEthyl acetoacetate(4-Hydroxy-3-nitrophenyl)acetateIsoetharineBURIMAMIDEMethylthiouracilThiaburimamide(R)-beta-alanopineGuanosine2-[(Pyrrolidinium-2-ylcarbonyl)amino]propanoateCytochalasin BDL-Pyroglutamic acid1,2-Dipalmitoleoyl-sn-glycero-3-phosphocholine1-O-Palmitoyl-2-O-acetyl-sn-glycero-3-phosphorylcholinePolyporusterone A2-Aminoisobutyric acidPorson2-Oxo-8-methylthiooctanoic acidCholine AlfoscerateGeneticinL-Homocysteic acidCinoxacinGlu-PheN-Acetyl-DL-tryptophanPindolol4-Hydroxy-3-iodophenylpyruvic acidD-ThreitolN-Acetylthreonine5-Methyl-2-furancarboxaldehydeNeryl acetate1-MethylphenanthrenePhenethylamineNelarabineTriacetin1-Isopropenyl-3-isopropylbenzenePyroquilonDiethanolamineObacunone2-Chloroquinoline1-Palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholineZafirlukastSuberylglycine3-Methylglutaconic acidMG(18:2/0:0/0:0)5,5-Dimethyl-1-pyrroline N-oxideButyl 4-aminobenzoate11-Hydroxyhexadecanoic acidArg-gly-asp-serNornicotineL-Dopa4-Hydroxycoumarin1-Naphthylamine[(4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl] phosphono hydrogen phosphateCyclohexaneacetic acidHypotaurine3-hydroxy-2-(hydroxymethyl)-2-[(sulfooxy)methyl]propanoic acid6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dioneN-formimidoyl-L-aspartic acid2-DodecenalLevofloxacin(R)-3-hydroxybutyrylcarnitine1-DeoxynojirimycinNonadecanoic acid, 1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-2-[(1-oxohexadecyl)oxy]ethyl ester, (R)-Metoclopramide2-Amino-5-oxohexanoic acidSpermidineIsofraxidinS-Phenyl-N-acetylcysteineLPC(0:0/16:0)L-Cladinose6-O-Acetylarbutin3,8'-BiflaviolinPhenylbutyrylglutamineSulforaphene(+/-)-8-Hydroxy-5Z,9E,11Z,14Z,17Z-eicosapentaenoic acidPhenazopyridineUrocanic acidLPE(18:0/0:0)N,N-dimethylargininePC(15:0/18:4(6Z,9Z,12Z,15Z))N-(2-Furoyl)glycineTRIETHYL PHOSPHATEMethyl aminolevulinateAllopregnane-3beta,11beta,17alpha,21-tetrol-20-one(1S,5R,8R,10S,11R,13R,14S,15S,16R)-7-ethyl-5-methyl-12-methylidene-7-azahexacyclo[7.6.2.210,13.01,8.05,16.010,15]nonadecane-11,14-diol1,2-di-[(11Z)-eicosenoyl]-sn-glycero-3-phosphocholinebeta-N-Methylamino-L-alanineN-(9Z-octadecenoyl)-sphing-4-enine-1-phosphocholinePsicoseCrotyl alcoholOctanolLysergamide3,3'-Diaminobenzidine3-PyridinemethanolTetraethylene glycol[2-[(9Z,12Z)-octadeca-9,12-dienoyl]oxy-3-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphateAstemizole2-Acetylfuran4-NitrophenolOctadecanamide2-HydroxypyridineCarnitine C2:01H-Imidazol-1-ylacetic acidCreatinine9-DecenolFluchloralinO-Decanoyl-L-carnitine3-Aminobutanoic acidCarnitine isoC4:0Monomenthyl succinate4-AminocatecholAcetyl-L-carnitineLevomethorphan1-O-Hexadecyl-sn-glycero-3-phosphocholine(+)-PenbutololD-XylonateLichenin5-Aminopentanoic acid5'-Deoxy-5-fluorocytidine2-PhenylacetamideN-AcetylleucineOglufanideHexaethylene glycolN-ethylmaleimidePalmitic amide6-(2-Carboxyacetyl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acidBetaineL-Alanine2-Methoxy-5-nitroaniline2-HexadecenalMitoxantrone1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine3-Formylsalicylic acidL-Tyrosine ethyl ester4-Acetamidobutanoic acidPterin1-Aminocyclopropane-1-carboxylic acid(2-methyl-3-phenylpropoxy)sulfonic acid1-HeptanolPC(18:0/18:2)Cytidine1-Stearoyl-2-myristoyl-sn-glycero-3-phosphocholineLathyrineCarvyl acetate4-(Aminomethyl)benzoic acidIsoquinolineThalsiminePyridostigmine2-Aminoadipic acidVecuroniumNarcobarbitalAzelaoyl PAF2-NonanoneMisoprostolGenipinOctylamine1-(9Z-tetradecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol¦Ã-Aminobutyric Acid3,5-Dimethyl-1-hexyn-3-ol4-Methylvaleric Acid7-NitroindazoleN-Methylalanine2-PhenylpropanalDidesmethylsibutramineMetoprolol6,7,8-Trihydroxy-2H-1-benzopyran-2-oneN-Palmitoylsphingomyelin4-Hydroxyphenylglyoxylic acidNootkatone2-[[2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoic Acid3-Penten-2-oneProgesteroneBenzylamineN-(4-Hydroxyphenyl)glycineBenzo[b]naphtho[2,1-d]thiopheneN5-methylglutamine(2r)-3-(Hexadecyloxy)-2-methoxypropyl 2-(trimethylammonio)ethyl phosphate2-Benzylsuccinic acid1,2-DimethoxybenzeneAngiotensin IIIEphedrine2-Methylvaleric acid4-ChloroanilineL-Homoserine1,2,3,7,8-Pentachlorodibenzo-P-dioxinFlutriafol4-Guanidinobutyric acidp-SynephrineGlyc-ProPhosphoenolpyruvate3-AminophenolSparfloxacinKynurenic acid4-VinylguaiacolLPC(O-16:0/2:0)(Z)-1-(Methylthio)-5-phenyl-1-penten-3-yne2,8-QuinolinediolEsmololMethionineBarbituric acidp-Coumaryl alcohol 4-O-glucosideDeisopropylatrazinePentostatinBenzamidine2-Methyl-3-thioacetoxy-4,5-dihydrofuranEthyl hexadecanoateMet-Met[(2R)-1-[[(2S)-2,3-dihydroxypropoxy]-hydroxyphosphoryl]oxy-3-(10-methyldodecanoyloxy)propan-2-yl] 22-methyltetracosanoateCys-CysRhapontigenin3-[(4aS,12aR)-2-methyl-1,3,4,5,12,12a-hexahydropyrido[3,4-b]acridin-4a-yl]phenol2-Amino-6-methoxypurine1-ButanolButenoyl-PAF3-MethoxytyramineNeostigmineVigabatrinL-Norleucineo-Phenylenediamine1,2-DidecanoylglycerolArmillarinPeonidin chlorideN-EthylacetamideNiacinamide1-Acetoxy-2-hydroxy-16-heptadecyn-4-one6-[(3-Hydroxy-5-methoxyphenyl)methyl]-2-methyl-2,3-dihydropyran-4-one1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineL-HomoarginineSanguinarineFerulic acidHemine2(5H)-FuranoneN-Hydroxy-L-asparagine3,3'-DimethylbenzidineDI(Hydroxyethyl)ether3-(Methylthio)propionic acid5-Hydroxymethyl-2-furancarboxaldehydeIndole-3-propionic acidHexylamine1-Tert-butoxy-2-propanol4-Hydroxy-3-methoxybenzenemethanolTioproninD-phenylalanineGlycine, N-[imino(phosphonoamino)methyl]-N-methyl-Leu-EnkephalinGlycylglycineAminocaproic acidHarmineTriamcinolone diacetate2,3-Diaminopropionic acidPhytosphingosineVinburnineN-(Hydroxymethyl)acrylamideMethacholine2-AcetylpyrazineEthylmethylacetic acidIsopentenyl pyrophosphatepsi-PelletierineGallic acidLenticinalpha-Hydroxyisobutyric acid5'-Deoxy-5'-(Methylthio) Adenosine5-(Methylthio)-2,3-dioxopentyl phosphateCoumarinSpermineMyristic acid1-[3-(Trifluoromethyl)phenyl]piperazineHypoxanthineTemozolomideTetrahydrofurfuryl butyrate1,2-Dioleoyl-sn-Glycero-3-Phosphocholine3-Aminosalicylic acid2-Arachidonoylglycerol1-NitroheptaneCytarabineN6,N6,N6-Trimethyl-L-lysineN-NitrososarcosineOxindoleEtilamfetamineTropineDihydro-2-methoxy-2-methyl-3(2H)-thiophenone(S)-beta-Aminoisobutyric acidDeoxyvasicinoneGlycerol tripropanoateD-ProlineL-SerinePurineLumichrome2-PyrrolidinonePropargiteISOPRENELevonordefrin1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide1-PentanethiolDelphinidin 3-sambubiosideLPE(16:0/0:0)4-(Dimethylamino)butyl carbamimidothioate2,5-Dimethyl-1,4-dithiane-2,5-diolErythorbic acidUreidosuccinic acid(3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acidEdifenphosDiphenylpyraline1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholinePS(16:1(9Z)/22:4(7Z,10Z,13Z,16Z))xI-Dihydro-2-methyl-3(2H)-thiophenone2-Aminoethyl dihydrogen phosphateCucurbitacin BN-MethyltyramineNaphthaleneGlycidolDihydrouracil(R)-1,3-Octanediolcotinine N-oxide(E)-6-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradec-4-en-3-one1-(2,4,5-Trimethoxyphenyl)-1,2-propanedionePelargonidin chlorideN-(4-Aminobenzoyl)-Beta-AlanineProadifen5-Formyl-2-furancarboxylic Acid3,4-DihydroxybenzylamineGallocatecholDigoxigenin bisdigitoxosideDimethyl phthalatexi-3-Methyl-3-cyclohexen-1-olPicolinic acidPenitrem BMethyl 4-(methylthio)butyrateDiisobutyl phthalate2-PhenoxyethanolSumiki's acid(2-Oxo-1,2-diphenylethoxy)sulfonic acidPiperazineFurfuryl alcohol2-AminobenzimidazolePyroglutamic acidS-Glutathionyl-L-cysteinePropofolPyridoxamineDipivefrinIsopalmitic acidSuccinylacetoneFludrocortisone acetate5-Imino-2-methyl-1-cyclopenten-1-olButanal4-Hydroxy-3-(sulfooxy)benzoic acid(-)-Globulol(+/-)-High Proline4-Azaniumyl-4,5-dihydro-1,2-oxazol-3-olate(2E)-Decenoyl-ACP1-Methyl-2-pyrrolidinoneButyl 3-methylbutanoate9-nitro-9E-octadecenoic acid4-Allyl-2,6-dimethoxyphenolDibutyl phthalate1-Palmitoyl-2-myristoyl-sn-glycero-3-phosphocholineGlucurolactoneNorsalsolinolTranexamic AcidArcaine3-MethylglutarylcarnitineTerbutalinePhenazine-1-carboxylic acidD-AlanineIndole-3-acetamideAllyl methyl sulfoxideD-HomocysteineN-Nitroso-pyrrolidineBenzaldehyde3,7-Dimethyl-3-octanol1-Oleoyl-2-palmitoyl-sn-glycero-3-phosphocholineHistamine2-PentylthiopheneClopidol6-Dimethylaminopurine7-Deoxyloganetic alcoholPoloxamer-188VERBENONEN-Furfurylformamide2-[(2-Amino-3-hydroxypropanoyl)amino]-3-sulfanylpropanoic acidLPC(14:0/0:0)Methionine sulfoxideNormetanephrineAllantoic acidGinkgolic acidPC(O-16:0/O-1:0)2-Amino-2-methyl-1,3-propanediol2-Aminobenzoic acidEpinephrine4-Chloro-L-phenylalanineAlbizziin(2-(Dimethylamino)ethyl)phosphonic acidCarnitine-2-methyl-C42,2,5,7,8-Pentamethyl-6-chromanol1-pentadecanoyl-2-(11Z,14Z-eicosadienoyl)-glycero-3-phosphocholineWin VINorvalinefalseExploring the Effects of Different Exercise Modalities on Skeletal Muscle Function in High-Fat Diet-Induced Obese Mice Based on Gut Microbiota and MetabolomicsExploring the Effects of Different Exercise Modalities on Skeletal Muscle Function in High-Fat Diet-Induced Obese Mice Based on Gut Microbiota and 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