MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13997/m_MTBLS13997_LC-MS_negative_reverse-phase_metabolite_profiling_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13997/m_MTBLS13997_LC-MS_positive_reverse-phase_metabolite_profiling_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13997/s_MTBLS13997.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13997/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13997/a_MTBLS13997_LC-MS_positive_reverse-phase_metabolite_profiling.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13997/a_MTBLS13997_LC-MS_negative_reverse-phase_metabolite_profiling.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS13997<p>These metabolites were annotated using the KEGG database and LIPIDMaps database . Principal components analysis (PCA) and Partial least squares discriminant analysis (PLS-DA) were performed at metaX (a flexible and comprehensive software for processing metabolomics data). We applied univariate analysis (t-test) to calculate the statistical significance (P-value). FC refers to the fold change, which is the ratio of the mean of all biological repeated quantitative values of each metabolite in the comparison group. The differential metabolites were screened using VIP, P-value and FC. The specific standard outlined in Table 5.3 of the report. Volcano plots were used to filter metabolites of interest which based on log2(FoldChange) and -log10(p-value) of metabolites by ggplot2 in R language.</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phase<p>UHPLC-MS/MS analyses were performed using a Vanquish UHPLC system (ThermoFisher, Germany) coupled with an Q ExactiveTM HF mass spectrometer in Novogene Co., Ltd. (Beijing, China). Samples were injected onto a Hypersil Goldcolumn (100×2.1 mm, 1.9μm) using a 12-min linear gradient at a flow rate of 0.2 mL/min. The eluents for the positive and negative polarity modes were eluent A (0.1% FA in Water) and eluent B (Methanol). Q ExactiveTM HF mass spectrometer was operated in positive/negative polarity mode with spray voltage of 3.5 kV, capillary temperature of 320°C, sheath gas flow rate of 35 psi and aux gas flow rate of 10 L/min, S-lens RF level of 60, Aux gas heater temperature of 350°C .</p>Gut microbiota-mediated histidine deficiency drives testicular ferroptosis induced by bisphenol F exposure.Jilin Universityboyang zhangfecesmass spectrometry assay<p>The cecal fecal samples of the BPF-200 animals were individually grounded with liquid nitrogen and the homogenate was resuspended with prechilled 80% methanol by well vortex. The samples were incubated on ice for 5 min and then were centrifuged at 15,000 g, 4°C for 20 min. Some of supernatant was diluted to final concentration containing 53% methanol by LC-MS grade water. The samples were subsequently transferred to a fresh Eppendorf tube and then centrifuged at 15,000 g, 4°C for 20 min. Finally, the supernatant was injected into the LC-MS/MS system analysis</p>Mus musculushttps://www.ebi.ac.uk/metabolights/MTBLS13997boyang zhang. Jilin University. zhangboyang199807@163.com.Xue-Ming Zhang. Jilin University. zhangxuem@jlu.edu.cn.<p>These metabolites were annotated using the KEGG and LIPIDMaps database . Principal components analysis (PCA) and Partial least squares discriminant analysis (PLS-DA) were performed at metaX (a flexible and comprehensive software for processing metabolomics data). We applied univariate analysis (t-test) to calculate the statistical significance (P-value). FC refers to the fold change, which is the ratio of the mean of all biological repeated quantitative values of each metabolite in the comparison group. The differential metabolites were screened using VIP, P-value and FC. The specific standard outlined in Table 5.3 of the report. Volcano plots were used to filter metabolites of interest which based on log2(FoldChange) and -log10(p-value) of metabolites by ggplot2 in R language.</p>Treatmentzhangboyang199807@163.com<p>Male Kunming mice (7-8 weeks old) provided by the Experimental Animal Center of Bethune Medical College at Jilin University were maintained under standard laboratory conditions (22-23°C, 12-h light/dark cycle) with free access to food and water. This study was approved by the Institutional Animal Care and Use Committee of Jilin University and strictly conducted in compliance with the revised ARRIVE 2.0 guidelines. Based on preliminary experiments, BPF dissolved in dimethyl sulfoxide was administered at three dose levels (50, 100, and 200 mg/kg/day) via oral gavage. The animals were randomly allocated into four groups (n = 6/group): vehicle control (Con), BPF-50 (50 mg/kg/day), BPF-100 (100 mg/kg/day), and BPF-200 (200 mg/kg/day). After 28 consecutive days of treatment, all mice were euthanized by cervical dislocation, the serum samples were collected</p>Metabolomicsbisphenol FferroptosisIntestinal Florauntargeted metabolite profilingbisphenol FferroptosisIntestinal Florauntargeted metabolite profiling<p>Q ExactiveTM HF mass spectrometer was operated in positive/negative polarity mode with spray voltage of 3.5 kV, capillary temperature of 320°C, sheath gas flow rate of 35 arb and aux gas flow rate of 10 arb, S-lens RF level of 60, Aux gas heater temperature of 350°C .&nbsp;</p>SL 17:0;O/15:1;OLPS 16:02,3-Dinor-8-epi-prostaglandin F2¦ÁProstaglandin G2DL-Panthenol3,3-Dimethylglutaric acid(2R)-2,3-Dihydroxypropanoic acidFAHFA 17:0/2:0N-Acetyl-L-histidine13(S)-HOTrELysope 14:0Dl-3,4-Dihydroxymandelic AcidLysopa 16:06¦Â-Prostaglandin I113,14-dihydro Prostaglandin F1¦ÁGamma-CaprolactoneFeruloyl PutrescineIsobutyryl carnitineHexanoylglycineCer 26:0;3O/16:1;(2OH)HexCer 22:0;2O/12:1;OL-TyrosinemethylesterProstaglandin H13,8,9-trihydroxy-10-propyl-3,4,5,8,9,10-hexahydro-2H-oxecin-2-oneProstaglandin H22-Anisic acid2,3-Dinor-TXB2CitrullineFAHFA 2:0/24:2N2-Methylguanosine(¡À)8(9)-DiHETFAHFA 2:0/24:1FAHFA 18:2/20:4LPE 13:0Syringic acid8-iso-15-keto Prostaglandin E2N-Acetylaspartic acidMesaconic acidUrsolic acid3-Hydroxyanthranilic acid4-Hydroxybenzylalcohol9-HOTrEPE-Cer 12:0;2O/23:0;OPI-Cer 12:0;2O/21:0;OProstaglandin E1FAHFA 24:4/2:0trans-10-Heptadecenoic AcidMGDG O-13:1_5:0THCCer 18:2;2O/16:0;(2OH)PhellamurinParacetamolMevalonic acid8,8'-dicarboxy-1,1'-binaphthalene4-EthylphenolGlutaric acidPG 5:0_18:2LPG 2:0FAHFA 20:4/22:53-[(4-chlorophenyl)thio]-1-(3-pyridylmethyl)pyrrolidine-2,5-dione15(R),19(R)-Hydroxy prostaglandin F2¦Áall-cis-4,7,10,13,16-Docosapentaenoic acidCer 18:0;2O/32:1;(3OH)LPA 24:1gamma-NonanolactoneCaffeic acid1-methyl-N-(4-piperidinophenyl)-1H-imidazole-4-sulfonamideIsophorone2-[(carboxymethyl)(methyl)amino]-5-methoxybenzoic acidLPE 14:0MGDG 18:2_18:3N-Acetylneuraminic acidPantothenic acidLPS 14:0Tyrosylalanine13,14-Dihydro-15-keto prostaglandin F2¦Á3-[4-(tert-butyl)anilino]-2-(3-thienylcarbonyl)acrylonitrileGuanosineN-Acetyl-L-methionineErucic acidXanthurenic acid4-Acetamidobutyric AcidLPA 16:03-(1,1,2,3,3,3-hexafluoropropyl)adamantane-1-carboxylic acidChenodeoxycholic AcidSpiculisporic Acid11(Z),14(Z)-Eicosadienoic acidN-FormylkynureninePG 4:0_15:0Cyclocytidine13,14-Dihydro prostaglandin E1Hexadecanedioic acid17¦Á-HydroxyprogesteroneFAHFA 2:0/22:0SL 17:0;O/15:0MGDG 18:3_18:3Prostaglandin D3Prostaglandin D28Z,11Z,14Z-Eicosatrienoic acidPG O-12:0_20:47-(4-methylpiperazino)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dithione(+/-)9(10)-EpOMEUridine2-PhenylglycineOrnithineN-Acetyl-DL-tryptophan2,4-dichloro-N-{2-[(2-furylmethyl)amino]-1-methyl-2-oxoethyl}benzamideLPC 20:5FAHFA 20:5/22:5trans-Petroselinic acid4-chloro-1H-indazol-3-amineFAHFA 4:0/18:0trans-2-Butene-1,4-dicarboxylic Acid4,7-dimethylpyrazolo[5,1-c][1,2,4]triazine-3-carbonitrile(¡À)10(11)-EpDPAPG 16:0_16:1LPC 20:1LPC 20:2Prostaglandin A3PG 4:0_14:0Testosterone sulfateFAHFA 20:4/20:3DL-3,4-Dihydroxyphenyl glycolEthyl-¦Â-D-glucuronideLPG 4:015-Deoxy-¦¤12,14-prostaglandin D2o-Cresol(+/-)-Cannabichromeorcin3-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)hydrazono]pentane-2,4-dioneMethyl acetoacetatePyridoxine O-GlucosideLysope 18:1Uric acidSHexCer 32:1;2O3-(2-Hydroxyethyl)indoleLNAPE 18:2/N-18:2LPE 12:0Fumaric acidAcetylcarnitinePE-Cer 12:0;2O/22:0;OArgininosuccinic acidCyclohexaneacetic acidPI-Cer 12:0;2O/22:0;O2-IsopropylmalatePhenylpyruvic acidPhe-Pro2-DeoxyuridineSucrose2-Hydroxy-2-methyl-3-buten-1-yl beta-D-glucopyranosideMethylsuccinic acid3-methyl-4-[2-(2-methylphenyl)hydrazono]-4,5-dihydro-1H-pyrazol-5-oneTetradecanedioic acidDocosahexaenoic acidFAHFA 20:2/20:1O-AcetylserineLPE 20:2LPE 20:3LPE O-18:0LPE O-18:1LPE 20:4LPE O-18:2PhloretinMinocyclineLPC 18:2N-Acetyl-L-tyrosine¦Ä-Ribono-1,4-lactoneLPI 16:0FAHFA 2:0/20:112-oxo Phytodienoic AcidLPC 18:0FAHFA 2:0/20:02-Isopropylmalic acidLPC 18:12,6-dimethoxy-N-(1-methyl-1H-pyrazol-5-yl)benzamideMethyl EudesMate5 methyl THFtrans-Cinnamic acidPhenylacetaldehydePG O-21:2_20:5DL-Tryptophancis-7-Hexadecenoic AcidTrehaloseSuberic acidJNJ-1661010Cer 20:2;3O/20:1;(2OH)FAHFA 22:5/22:5cis-2-Decenoic acidDGDG O-26:6_2:0LPE O-17:1Epinephrine bitartrateButylparabenLPE O-17:2LPC 19:1PG 4:0_16:0N-AcetylphenylalaninePE O-19:0_20:54-Methoxycinnamic AcidLPI 15:0LNAPE 20:5/N-26:6LPC 19:011(E)-Eicosenoic AcidXanthosineD-ThreoseN-(1,3-benzodioxol-5-yl)-7-chloroquinolin-4-amineCitric acidPG O-22:4_14:0D-Turanose(+/-)19(20)-DiHDPAGlycolithocholic acidLPG 20:1CUMYL-PICA N-pentanoic acid metaboliteFAHFA 20:2/22:4Homocysteic acid¦Â-D-Glucopyranuronic acidLPE O-16:12'-DeoxyuridineDGMG (18:2)5-AminopentanoateOrotidineJasmonic acidChenodeoxycholic acid-3-beta-D-glucuronideL-AscorbateHesperetinN-Acetyl-DL-glutamic acid2-Hydroxycaproic acid3-Phenyllactic acidCinnamoylglycineCer 17:0;2O/17:0;(3OH)Asp-PheMGDG O-20:0_18:3Hydroquinone2,5-Dimethylphenol3-(2-thienyl)-1,2,4-oxadiazole-5-carbohydrazideOfloxacin impurity ETaurochenodeoxycholic acidVanillyl alcoholMGDG O-18:4_16:023-Nordeoxycholic acidGenisteinMonobenzyl phthalateHydrocortisoneGenipinLPE O-15:110-Hydroxydecanoic acidL-AdrenalineLactobionic acidPG 4:0_18:1cis-Aconitic acidLPE O-15:03-[4-methyl-1-(2-methylpropanoyl)-3-oxocyclohexyl]butanoic acid4-Hydroxy-3- methoxyphenylglycol sulfateLNAPE 18:0/N-16:2StercobilinN-Acetylglucosamine 1-phosphate1-(2,4-dihydroxyphenyl)-2-(3,5-dimethoxyphenyl)propan-1-oneD-RiboseLPG 22:64-Hydroxyphenylacetic acidaminoimidazole carboxamide ribonucleotide(¡À)9(10)-DiHOMEPunicic AcidTaurineDocosanoic AcidNaringeninAllantoinXanthohumolHydrocinnamic acid7-Hydroxy-3,4-dihydrocarbostyrilMGDG O-10:0_4:0Lithocholic acid2-Hydroxyhippuric acidN-Acetylsphingosine8(S),15(S)-DiHETE(¡À)9(10)-EpOMEN-(2,5-diethoxy-4-morpholinophenyl)-4-methoxybenzenesulfonamide5-[4-(2-furylcarbonyl)piperazino]-5-oxo-3-phenylpentanoic acidProstaglandin F3¦Á2-[(3S)-1-(Cyclohexylmethyl)-3-pyrrolidinyl]-5-fluoro-1H-benzimidazoleLPG O-14:1alpha-Ketoglutaric acidDL-Malic acidMethylmalonateST 24:2;O4PG O-22:2_18:1Docosatrienoic acid2'-DeoxyinosineN1-(3-pyridyl)-2,3,4,5,6-pentamethylbenzene-1-sulfonamideCatecholPorphobilinogen4-OxoprolineTyrosolL-ArabinitolGuggulsteroneN6-Succinyl AdenosineCer 22:0;2O/12:0;O(FA 18:1)11-Dehydro thromboxane B21-MethylguanosinedTMPADBICA N-pentanoic acid metaboliteLysops 22:5CalcitriolL-PalmitoylcarnitineMGDG O-26:6_2:03-Hydroxyvaleric acid22(S)-HydroxycholesterolDocosapentaenoic acidOctanedioic acid6-Deoxy-D-glucoseL-TryptophanPG 3:0_16:0Indole-2-carboxylic acid3-Methyladipic acidHexCer 18:0;3O/16:0;(2OH)Lysops 22:6Pentadecanoic acidLPG O-15:15-(3-chloro-4-methylanilino)-1-methyl-1H-pyrazol-3-ol4,6-dimethyl-2-(methylamino)-5-nitronicotinonitrileThymidine 5'-monophosphateHBMP 18:2_18:2_12:0FAHFA 3:0/20:0dCMPMGDG O-24:5_2:02-Methylpentanedioic acident-8-iso Prostaglandin F2¦ÁPG 22:6_22:62-(Formylamino)Benzoic Acid8,15-Dihete4-ThiouridineLPG O-26:4O-DesmethylnaproxenLeucylprolineKinetin 9-ribosideLysoPE 18:0N-AcetylmannosaminePG 18:2_22:6(+/-)7(8)-DiHDPAL-Cysteinesulfinic acidPG O-17:1_16:0Glu-Glu2'-Deoxyuridine-5-monophosphate4-Hydroxybutyric acid (GHB)8-iso-15-keto Prostaglandin F2¦Á17(S)-HpDHAHematoxylinDL-CitrullineLPG 14:0L-Ascorbic acid 2-sulfateProstaglandin F1¦ÂPMeOH 18:1_18:2MGDG O-24:1_20:4delta9-THC-d9ST 28:1;O;SFAHFA 18:1/3:04-HydroxymandelonitrileLPC 16:0FAHFA 4:0/22:0L-aspartic AcidCer 30:0;3O/12:1;(2OH)LPI 18:2Lauric acid ethyl ester1,2-DipalmitoylphosphatidylglycerolN-(4-chlorophenyl)-N'-(2-phenoxyphenyl)ureaSuccinic acidHypoxanthineProstaglandin A1 ethyl esterAdrenic acid4-[2-(2-oxo-1-imidazolidinyl)ethyl]-1lambda~6~,4-thiazinane-1,1-dioneLysopc 14:0PE-Cer 13:2;2O/22:4SL 16:0;O/16:1;O2-(2-carboxy-2-methylpropyl)-4,6-dimethylbenzoic acids7p2-[6-(1H-benzo[d]imidazol-2-yl)-2-pyridyl]-1H-benzo[d]imidazole15-Keto prostaglandin F2¦Á(2S)-4-Oxo-2-phenyl-3,4-dihydro-2H-chromen-7-yl beta-D-glucopyranosidemethadone-d9Fenbendazole sulfoxideLPG O-17:2LPE O-19:1Homovanillic acid5-MethoxyuridinePG 2:0_16:0UDP-N-acetylglucosamineLPG 15:0FAHFA 18:1/20:35-MethyluridinePG 3:0_18:1LPI 17:0L-Glutamic acid5-Hydroxyindole-2-carboxylic acidLPC 17:08(S)-Hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoic acidD-ProlineDl-3-HydroxynorvalinePE 18:1_18:2Cyclic ADP-riboseD-PhenylalanineN-Acetyl-D-galactosamine 4-sulfateGlutamineCorchorifatty acid FOxoadipic AcidN-Acetyl-L-phenylalaninePA 19:1_18:2MGDG O-13:1_2:0Cholic acidPalmitic acidArachidonic acidL-beta-Imidazolelactic acid19(R)-Hydroxy-prostaglandin E22,3-dinor Prostaglandin E13,4,5-trihydroxycyclohex-1-ene-1-carboxylic acid16-Hydroxyhexadecanoic acidLPG 16:0N-Oleoyl Glycine3,5-Dihydroxybenzoic acidAla-GlnCaffeineTyramine13-Hpotre(R)EsculinD-Mannose 6-phosphate(¡À)8-HEPENervonic acidLPA 21:1MGMG (18:2)Soyasaponin IMaltotrioseValproic acidSebacic acid(3-Methoxy-4-hydroxyphenyl)ethylene glycol sulfatePG 4:0_20:1Asp-Phe methyl esterLPE 17:1N4-Acetylcytidine4-Hydroxymandelic acidS-Adenosyl-L-methionineLPE 17:0MGDG O-18:4_2:03-(3-Methoxyphenyl)propionic acidPG 14:0_16:02-(1H-1,2,3-benzotriazol-1-yl)-N-(2,3-dihydro-1H-inden-2-yl)acetamideEstradiol BenzoateLPC 22:1EthylmalonateFlavin mononucleotide (FMN)D-(-)-Fructose3-Indoxyl sulphate4-Methyl-2-Oxopentanoic AcidSL 11:1;O/22:6LPC 22:6PG O-15:0_16:02-Hydroxyvaleric acidFAHFA 2:0/18:1FAHFA 2:0/18:01,4-Cyclohexanedicarboxylic acidQuinoline-4-carboxylic acidN-AcetylornithineGlycerol-3-phosphateLPG 17:0ApigeninLPG 17:1PG O-20:1_20:5PG 2:0_18:14-Methylphenol15(R)-Prostaglandin E2Salicylic acidN-(2-morpholinophenyl)-2,1,3-benzoxadiazole-4-sulfonamideDodecanedioic acid5-Aminovaleric acidD-¦Á-Hydroxyglutaric acidXanthineDeoxyguanosineLPE 18:0PEtOH 20:0_20:5LPE 18:119(R)-hydroxy Prostaglandin A22,4-Dihydroxybenzoic acidLPE 18:2LPE O-20:1LPE 18:3THJ2201 N-pentanoic acid metaboliteD(+)-Phenyllactic acidnor-6¦Â-OxycodolThymidineAldosteroneST 24:1;O4MGDG O-13:1_4:0¦Ä-Gluconic acid ¦Ä-lactone3-Hydroxysebacic acidPantetheineLPG 18:2Orotic acidMethylmalonic acidLPG 18:1LPG 18:0LactitolTryptophanolNicotinamide N-oxideFormononetineFAHFA 20:1/22:37-MethylxanthineInositolN-AcetylglycineAKB48 N-(4-hydroxypentyl) metabolitePG O-20:2_16:0FAHFA 20:4/2:02-Furoic acidlipoamideN-Acetyl-D-alloisoleucineFAHFA 20:3/22:5Undecanedioic acidPhenobarbitalDL-¦Á-Methoxyphenylacetic acidN-¦Á-Acetyl-L-asparagineSalvinorin B¦Â-Muricholic acidTetranor-PGDMNonadecanoic acidLysopc 18:3LPE 15:0LPE 15:1(R)-3-Hydroxy myristic acid1a,1b-Dihomo prostaglandin E1LPC 24:1Lipoic acid20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acidMGDG O-20:0_20:518-¦Â-Glycyrrhetinic acidElaidic acidFAHFA 2:0/16:03-Oxo-7alpha,12alpha-hydroxy-5beta-cholanoic acidMGDG O-15:1_4:019(R)-Hydroxy prostaglandin F1¦ÁAzelaic acid1,3-Dimethyluracil(+/-)9-HpODE2-Hydroxymyristic acidDimetghyl 4-HydroxyisophthalatePC 18:2_18:32-Hydroxy-4-methylthiobutanoic acidLPA 22:0MGDG O-16:2_16:0Deoxycholic acidFAHFA 22:4/2:011-keto Testosterone (CRM)MGDG O-11:0_4:0N-Isobutyrylglycine(¡À)9-HpODE2-Hydroxyphenylacetic acidGlycodeoxycholic acidEstroneD-2-Aminoadipic acidBiopterinMestranol2-Methoxyestradiol (2-MeOE2)falseGut microbiota-mediated histidine deficiency drives testicular ferroptosis induced by bisphenol F exposure<p>Bisphenol F (BPF),&nbsp;a widespread environmental contaminant and a major substitute for the restricted bisphenol A (BPA), has raised increasing concerns regarding its potential&nbsp;male reproductive health risks, yet its underlying mechanisms remain poorly understood. This study investigates the mechanisms underlying BPF-induced testicular damage, focusing on the interplay among gut microbiota (GM) dysbiosis, histidine metabolism disruption, and ferroptosis. Using a mouse model exposed to BPF (50, 100, and 200 mg/kg/day) for 28 days, we observed significant testicular pathology, including seminiferous tubule atrophy, vacuolation, and blood-testis barrier (BTB) impairment. Metagenomic and metabolomic analyses revealed GM dysbiosis and suppressed intestinal histidine metabolism, accompanied by decreased abundance of beneficial taxa (e.g., Bacteroides, Ligilactobacillus) and increased potential pathobionts (e.g., Akkermansia, Mucispirillum). BPF exposure also inhibited the expression of the histidine transporter LAT1, reducing histidine uptake in testes. Crucially, BPF triggered testicular ferroptosis, characterized by mitochondrial damage, iron accumulation, lipid peroxidation, and downregulation of the ferroptosis regulatory system xCT-GSH-GPX4 axis. In vitro experiments using mouse Sertoli cells (mSCs) confirmed BPF-induced ferroptosis, which was mitigated by the exogenous histidine supplementation. Histidine administration in vivo ameliorated testicular damage, restored BTB integrity, and reversed ferroptotic markers. Our findings unveil a novel “GM-histidine-testis” axis as a key mechanistic pathway for BPF-induced reproductive toxicity, providing critical insights into the health risks of emerging environmental pollutants and suggesting potential dietary intervention strategies.</p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