MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14016/m_MTBLS14016_LC-MS_negative__metabolite_profiling_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14016/m_MTBLS14016_LC-MS_positive__metabolite_profiling_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14016/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14016/a_MTBLS14016_LC-MS_negative__metabolite_profiling.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14016/s_MTBLS14016.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14016/a_MTBLS14016_LC-MS_positive__metabolite_profiling.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14016<p>Metabolite profiling was conducted using Metware's widely-targeted metabolomics technology, which combines high-resolution mass spectrometry (HRMS) for broad-spectrum metabolite identification with triple quadrupole mass spectrometry operating in multiple reaction monitoring (MRM) mode for precise quantification. Identification was achieved by matching the acquired MS/MS spectra against Metware's self-built standard database (MWDB) containing over 2,000 authentic compounds for human endogenous metabolites, based on accurate precursor mass (&lt;5 ppm), retention time alignment with standards, MS/MS fragmentation patterns, and isotopic distribution. Quality control samples were analyzed throughout to ensure data reliability.</p>MetaboLightsPublicLiquid Chromatography MS - positiveLiquid Chromatography MS - negative<p>Chromatographic separation was performed on a Waters ACQUITY UPLC HSS T3 C18 column (1.8 μm, 2.1 × 100 mm, Waters, Milford, MA, USA) using an ExionLC AD system (Sciex, Framingham, MA, USA). The mobile phase consisted of (A) ultrapure water with 0.1% formic acid and (B) acetonitrile with 0.1% formic acid. The gradient elution was programmed as follows: 0 min, 95:5 (A:B, v/v); 2.0 min, 80:20; 5.0 min, 40:60; 6.0 min, 1:99; 7.5 min, 1:99; 7.6 min, 95:5; and 10.0 min, 95:5. The flow rate was 0.4 mL/min, the column temperature was maintained at 40 °C, and the injection volume was 2 μL.</p>Please update the publication title.SpecAlly Life Technology Co., Ltd.Siqi Luoblood plasmablood serummass spectrometry assay<p _msttexthash='32273813' _msthash='715'>Serum samples were thawed on ice and vortexed for 10 s. A 50 μL aliquot was mixed with 300 μL of extraction solution (acetonitrile:methanol = 1:4, v/v) containing internal standards. After vortexing for 3 min, the mixture was centrifuged at 12,000 rpm for 10 min at 4 °C. Then, 200 μL of supernatant was transferred to a new tube, maintained at −20 °C for 30 min, and centrifuged again at 12,000 rpm for 3 min at 4 °C. Finally, 180 μL of supernatant was collected for LC-MS analysis.</p>Homo sapienshttps://www.ebi.ac.uk/metabolights/MTBLS14016Mao Enqiang. Ruijin Hospital, Shanghai Jiao Tong University School of Medicine. maoeq@yeah.net.Luo Siqi. luosiqi86@163.com.<p>Mass spectrometric detection was conducted on a QTRAP® instrument (Sciex) equipped with an electrospray ionization (ESI) source. The ESI parameters were set as follows: source temperature 500 °C; ion spray voltage 5500 V (positive) and −4500 V (negative); ion source gas I, gas II, and curtain gas at 55, 60 and 25 psi, respectively; collision gas set to high. Instrument calibration was performed using 10 and 100 μmol/L polypropylene glycol solutions. Specific MRM transitions were monitored for each metabolite according to their elution period.</p>Bacterial typeluosiqi86@163.com<p _msttexthash='32273813' _msthash='652'>Serum samples were collected at the time of sepsis diagnosis. Residual blood samples from routine clinical testing were used to minimize additional invasive procedures. Blood smears were prepared for microbiological confirmation of CRKP or CSKP. Serum was separated and aliquoted for storage at -80 °C to preserve sample integrity for subsequent multi-omics analyses</p>MetabolomicsMetabolomicsCarbapenem-Resistant Klebsiella pneumoniaeSepsisMetabolomicsCarbapenem-Resistant Klebsiella pneumoniaeSepsis<p>The sample extracts were analyzed using an LC-ESI-MS/MS system (UPLC, ExionLC AD, https://sciex.com.cn/; MS, QTRAP® System, https://sciex.com/). Chromatographic separation was performed on a Waters ACQUITY UPLC HSS T3 C18 column (1.8 μm, 2.1 × 100 mm) using an ExionLC AD system (Sciex). The mobile phase consisted of (A) ultrapure water with 0.1% formic acid and (B) acetonitrile with 0.1% formic acid. The gradient elution was as follows: 0 min, 95:5 (A:B, v/v); 2.0 min, 80:20; 5.0 min, 40:60; 6.0 min, 1:99; 7.5 min, 1:99; 7.6 min, 95:5; and 10.0 min, 95:5. The flow rate was 0.4 mL/min, column temperature was maintained at 40 °C, and the injection volume was 2 μL.</p>N1,N8-diacetylspermidineN'-Methyl-2-pyridone-5-carboxamide2'-O-methylcytidineIle-Thr4-toluenesulfonic acidCorticosteroneCarnitine C14:2:DCPhe-IleEctoineDl-3,4-Dihydroxymandelic AcidTrp-Val8,8a-deoxy-oleanePantothenol2-hydroxyphenylacetic acidKetoleucineL-Allothreonine3-Methylcrotonyl GlycineProline-Hydroxyproline9(S),12(S),13(S)-TriHOMEAAIminodiacetic acidLPC(18:1/0:0)Rhamnonic acidThymoquinoneMethanesulfonic acidN-acetyl-5-aminosalicylic acid3-Hydroxyanthranilic AcidCarnitine C15:DC5-Hydroxy-2'-deoxyuridinePGF3¦ÁGly-GluGly-GlnN-EthylglycineN-Methylisoleucine(¡À)18-HEPEDHA4-Hydroxybenzaldehyde4-hydroxyphenylglyoxylateFFA(16:4)2-Methyl-1-PyrrolineCarnitine C6-OHJasmoneCMPentylFAla-PheHydroumbellic acidL-TheanineN-PhenylacetylglycineHydroferulic acid1-Methylpiperidine-2-carboxylic acidCarnitine ph-C1Arachidonoyl LPAPiperonylic acidAldehydo-D-altroseMet-GluHexadecylamineLPE(17:0/0:0)Gly-Phe-PheProline betaine3-(3-Hydroxyphenyl)Propionate AcidMG(18:1/0:0/0:0)1,4-Dihydro-1-Methyl-4-Oxo-3-PyridinecarboxamideLPC(20:4/0:0)3-(2-Hydroxyphenyl)propanoic acidIsokaurenoic acid4-Amino-5-hydroxymethyl-2-methylpyrimidine14(S)-HDHAPro-GluPantothenic acidIndoxylsulfuric acidSalicylaldehydeGlycochenodeoxycholic acid 7-sulfate2-((2-(2-Hydroxyethoxy)-4-nitrophenyl)amino)ethanolSn-Glycero-3-PhosphocholineCarnitine C8-OH7-KetocholesterolDodecanedioic AcidAspartic AcidL-OrnithineFFA(16:2)IndoleacetaldehydeTrp-IleCarnitine C18:0Phe-GlyCarnitine C18:4N-¦Ã-Acetyl-N-2-Formyl-5-MethoxykynurenamineCarnitine C18:3Carnitine C18:2Carnitine C18:1AcetylvalineLPA(0:0/16:0)Cyclic AmpIle-GlnGlyceric Acid4-Methylhippuric AcidDl-2-Aminooctanoic AcidN(Alpha)-Acetyl-Epsilon-(2-Propenal)LysineFFA(16:3)7,8,4'-Trihydroxyisoflavone2,4-QuinolinediolLPC(22:5/0:0)MethylguanidineLPE(0:0/18:1)2-Aminoisobutyric Acid¦Ä-ValerolactamLPA(22:6)2-PentadecanoneAndrostenedioneUridine 5-MonophosphateCarnitine C3:1-2OH3-MethyladenineLPC(13:0/0:0)IndoleLPE(P-16:0)L-2-amino-6-oximelic acidPhe-ThrIle-GluIsocitric acidGlu-MetTyr-Gly3-MethyloxindoleLPE(0:0/18:2)DL-3,4-Dihydroxyphenyl glycolCyclo(Pro-Leu)TagatoseLPG(16:0)2,6,6-Trimethyl-2-cyclohexene-1,4-dioneInosine diphosphateL-ThyroxineDihydroactinidiolideIsogalactinolUric acidFFA(16:1)1,3,7-Trimethyluric Acid2-Hydroxycinnamic acidPro-IleGlycoursodeoxycholic AcidCarnitine C18:1-OHLPE(0:0/18:3)LPC(0:0/17:0)1-Aminocyclobutanecarboxylic acidLPG(16:1)1-desoxymethylsphinganineMelatoninTrp-Glu5-Methylcytosine2-hydroxypentanedioic acid2-pyrimidin-2-yl-propionic acid1-Hydroxylamino-2-phenylethaneTrp-GlyGuanidinoethyl SulfonateTraumatic acidTetradecanedioic acid3,3',5-Triiodo-L-ThyronineS1P(d16:1)CAP-palmitateL-CitronellolCarnitine C4-OHDL-O-tyrosineS-Allyl-L-cysteine2-Amino-4,6-pteridinediolCarnitine C9:1-OHCarnitine C3:0HexylresorcinolIle-IleLys-LeuEthyl-dodecanoategamma-Glu-PheHis-SerSPH(d18:2)Dehydroepiandrosterone sulfate2-Thio-PAFLysine3-Indolebutyric AcidUrocanic Acid4-Methyl-3-nitroanilineTrehaloseSuccinic anhydrideLys-AsnGuanineQuinmerac2-NaphtholLeu-MetAntineoplaston A103-Methoxysalicylic AcidSPH(d18:1)N-Acetyl-L-TyrosineLPC(16:0/0:0)N-Acetylglucosamine 1-Phosphate10-Hydroxy-2-Decenoic AcidTaurolithocholic acidIndole-3-CarboxaldehydeAcetanilideCarnitine C20:17-MethylguanineSPH(d18:0)1-MethyladenineCarnitine C20:4Carnitine C20:3Carnitine C20:28-Methylnonenoate2-Undecanone5,6-DihydrouridineCarnitine C14:2-OHFFA(14:0)5,6-Dihydro-5-Methyluracil13(R)-HODEPhe-ValMultifidol5-MethoxytryptophanTXB22-(2-Propynyloxy)-benzenehexanoic acidS-Sulfo-L-Cysteine2'-DeoxyuridineCarnitine C5:1Carnitine C5:0OrotidineFFA(9:0)2-Methylglutaric AcidGlycochenodeoxycholic AcidFFA(14:1)5-nitrobenzimidazoleLPE(P-18:1)Indole 3-carbinolS-Methyl-L-Cysteine-S-oxideAsp-PheCyclo(Ala-Pro)4-HydroxyhippurateGeranic acidPropofol GlucuronideQuinoline-2-carboxylic acidMonobutyl phthalateLPC(0:0/15:0)6-aminonicotinamide2,4-DihydroxypteridineGuanidineL-Cysteic acidGlutathione OxidizedMyoinositolL-TryptophanamideLPA(16:1)Dibutyl-phthalateLPE(0:0/16:0)Octadec-9-ene-1,18-dioic-acidCarnitine C16:1-2OHChrysin-7-O-glucuronideThymineDL-LeucineTriacetonaMine2-(Acetylamino)-2-deoxy-A-D-glucopyranose4-Hydroxy-2-Oxoglutaric Acid1-MethyladenosineLPS(20:0)Glycohyocholic acid2-Hydroxy-3,4-dimethoxybenzoic acidN(6),N(6)-Dimethyl-L-lysineTroloxLPE(0:0/16:1)9,10-DiHOMESarcosine2-Hydroxy-4-(methylthio)butyric acidN-Alpha-Acetyl-L-AsparagineHeparinPinolenic acidN-PalmitoylglycineSorbitolTaurine1-NaphtholPropyrazol1-Deoxyvaleric acidLPC(17:2/0:0)12-ketolithocholic acidOchratoxin ALithocholic acidLPC(O-18:2)Met-TrpFFA(22:6)3-CarboxypropyltrimethylammoniumIsopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoateCarnitine C12:12-HydroxyethanesulfonateL-ThreonineCarnitine C12:0Carnitine C16:1-OHTridecanedioic acidGln-GlyCarnitine C12:33-Amino-4-Hydroxybenzoic AcidAgmatine6-hydroxy-3-succinylpyridine4-AminophenolTrigonelline3-UreidopropionateN-Acetyl-Asp-GluLPC(16:1/0:0)Leu-Leu-LeuLPE(0:0/14:0)Apocholic acid11,12-EETS1P(d18:2)(E)-GuggulsteroneOxaloacetic acidLPC(20:2/0:0)N-PropionylglycineLPC(O-18:3)FFA(22:7)Ribonic acidMeestrolN6-Succinyl AdenosineCarnitine C159-FluorenoneFFA(12:0)2-Naphthalenesulfonic acid(R)-2-Hydroxy-3-phenylpropionic acid2-(10-Heptadecenyl)-6-hydroxybenzoic acidVal-IleLPC(0:0/22:6)20-COOH-AAAmmelideCarnitine C6:1L-Tryptophan3-Hydroxyhippuric AcidCarnitine C6:0TriethanolamineLPC(15:0/0:0)FFA(22:4)4-Guanidinobutyric Acid8,15-DiHETEIndole-4-carboxaldehyde9(S)-HOTrECholesterolFFA(22:5)2-Hydroxy-6-AminopurineL-2-Aminobutyric acidTestosteroneO-DesmethylnaproxenD-Ribono-1,4-lactoneAsn-TrpHexaethylene-glycol2-methyl citric acidL-ValineUracilTryptamine2-Hydroxy-4-methylpentanoic acid3-Indolepropionic Acid2-Amino-4-methylphenolLPE(0:0/22:6)N-Acetylaminooctanoic acidCreatine1-Methyl-hydantoinDL-HomocysteineN,N-Bis(2-hydroxyethyl)dodecanamideCarnitine C10:0o-Methoxyphenyl sulfateCarnitine C10:2Hippuric AcidCarnitine C10:1BiotinamideCytosineSedoheptulose 7-PhosphateTyr-AspLPC(0:0/12:0)Aleuritic AcidL-Cystine3-(pyrazol-1-yl)-L-alanineSuccinic AcidHydroxyquinolineLPC(0:0/22:5)3-Bromotyrosine9(S)-HODE3,6,9,12,15,18,21-Heptaoxatricosane-21,23-diolCarnitine C11:DC3-(Methylthio)-1-propanol5-HydroxyisourateCarnitine C8:121-DeoxycortisolCarnitine C8:0Carnitine ph-C14gamma-Glu-AlaHydroxyurea4-Methoxysalicylic AcidN-Acetyl-L-LeucineS1P(d18:1)HypaphorinePyrrole-2-Carboxylic Acid11¦Â-Prostaglandin F2¦ÁLPC(18:0/0:0)LPC(O-18:0)LPE(20:5/0:0)Nicotinuric AcidSer-ProQuinolinic acid3-phenylphenolMet-Asp¦Ã-Glu-GlnProstaglandin F2¦ÁGlycohyodeoxycholic acidHis-TrpL-HomocystineS-(5-Adenosy)-L-HomocysteineN,N-Dimethylglycine9,10-Epoxy-18-hydroxyoctadecanoic acidCanrenone2-Methylhippuric acid2-Octanamidoacetic acidLys-Met2-Hydroxy-3-Methyl Butanoic AcidFructose(¡À)11(12)-DiHETCyromazineFAHFA(8:0/10:0)NorepinephrineLPE(16:1/0:0)N-Acetylaspartatecis-EODAAsp-Leu3-Hydroxyphenylacetic acidN-Acetyl-L-phenylalanineFFA(10:0)AndrostenediolHydroxypiperazic acid(R)-(-)-Mandelic acidp-Cresol glucuronideTrp-LeuN¦Á-Acetyl-L-ArginineHistidine16-Hydroxyhexadecanoic acidImidazole-4-methanolCarnitine C16:2Thr-ArgDiethylstilbestrolCarnitine C16:13,5-Dihydroxybenzoic acidCarnitine C16:0FFA(20:4)Aconitic AcidCarnitine C16:3D-Erythronolactone2-Amino-3-phosphonopropionic acidLPC(18:4/0:0)FFA(10:1)L-CitrullineCarnitine C16-OHalpha-Asarone2-ethyl-2-hydroxybutyric acid12-Hydroxydodecanoic acidGly-ValN-Acetyl-D-Tryptophancyclo(leu-phe)Ser-AlaDiglycidyl-resorcinol(3-Methoxy-4-hydroxyphenyl)ethylene glycol sulfate3-Methoxyphenylacetic acidN4-Acetylcytidine4-Hydroxy-3-methoxybenzaldehyde2-amino-4-oxovaleric acidErgothioneineAla-SerLosartan carboxylic acidTripropylamineHis-Phe-AlaLPE(0:0/22:4)O-Phospho-L-SerineCyclo(his-pro)Ethionamide2-Hydroxy-4-methylbenzaldehydeAsn-Pro1,4-Cyclohexanedicarboxylic acidLPC(0:0/20:4)Protocatechuic Acid4-Hydroxy-3-methylbenzoic acidFFA(20:2)Arg-Leu6¦Â-hydroxytestosteroneHydroxyphenyllactic acid4-Hydroxybenzoic AcidN,N¡ä-dicyclohexylcarbodiimideSalicylic acidErythrose(R)-3-Hydroxy-tetradecanoic acid2,4-diacetamino-2,4,6-triphenoxy-D-mannopyranoseIle-MetLPE(0:0/22:5)XanthineGlu-Phe-AlaMarmesin(R)-(-)-2-PhenylglycinolLPC(0:0/20:5)L-GlutamineDi-n-propyl-phthalateCholineHeptethylene-glycolHis-LeuVal-Thr3-(2-Naphthyl)-L-alanineSDMAFlavanoneCarnitine C10:1-OH1-Aminopropan-2-olL-Isoleucine3-hydroxyhexadecanoic acid1-pyrroline-4-hydroxy-2-carboxylate2-(((2-Ethylhexyl)oxy)carbonyl)benzoic acidLPE(20:2/0:0)Carnitine C14:0LPE(0:0/20:3)3-Hydroxypyruvic acidCarnitine C14:2Carnitine C14:1Mandelic Acid12,13-EpOMEGluconic acidVal-GluN-AcetylglycineAla-Lys3-Amino-4-methylpentanoic acidHyp-SerLPC(20:5/0:0)LPC(0:0/20:2)Val-GlyFFA(19:2)Pro-AsnPro-Asp2-MercaptobenzothiazoleLPE(0:0/20:4)DehydrozingeroneGalacturonic acid4-Methylhexanoic acid3-(4-Hydroxyphenyl)-1-propanolOrotic AcidIsolithocholic acidN-Methyl-D-Aspartic AcidN-(2-hydroxyethyl)-3-pyridinecarboxamide10-Formyl-ThfL-3-Phenyllactic acidD-urobilinogenTrans-3-Hydroxycotininep-CresolCarnitine C17:1:DC2-(Dimethylamino)GuanosineLPE(0:0/20:5)N-(2-Hydroxyethyl)pentadecanamide5-hydroxyindole acetaldehydePiperidineD-OrnithineAzelaic AcidL-2-Aminoadipic acidInositol 1-phosphateCarnitine C18-OH9,10-dihydroxystearic acidDethiobiotin3-Guanidinopropionic acidIsocytosine2,3-Dihydroxybenzoic acidIndole-3-carboxylic acidLactose3-Aminoquinoline5-Hydroxypyridine-2(1H)-one2-Hydroxy-2-Methyl Butyric acidP¨CHydroxyphenyl Acetic AcidMethylmalonic Acid1,7-DimethylxanthineThr-PheSorbitol 6-phosphateRiboflavin2-Methyl-d-erythritol 2,4-cyclodiphosphateLPC(19:2/0:0)3,3-Dimethylglutaric acid3-(4-Fluorobenzoyl)propionic acid11-Beta-hydroxyandrostenedione2-Hydroxy-2-methylbutanenitrileUrolithin AGlu-LeuLPC(0:0/18:2)Indole-3-Acetic AcidLys-ValCarnitine C14:1-OHGlucoronic AcidO-Acetyl-L-serineLPC(14:1/0:0)Estradiol cypionateBiotinL-ProlineUreaLeu-AsnLeu-AspOctadecanedioic acidLPC(0:0/18:3)Methyl beta-D-galactopyranoside(¡À)15-HETEN-MethyTrans-4-Hydroxy-ProlineN1-Acetylspermidine5-Aminoimidazole ribonucleotide3-MethylthiopropylaminePiperidine acidPhthalic AcidFFA(17:1)Val-Ala(R)-2-Hydroxybutyric acidMurideoxycholic acidCarnitine C18:2-OHLPE(22:5/0:0)(4Z,7Z,10Z,13Z,16Z,19Z)-EicosahexaenoateLPC(0:0/18:0)LPC(O-14:0)9(S)-HpOTrEBenzylcinnamateCarnitine C14-OH5-HydroxytryptopholMethylcysteineFFA(17:2)P-Coumaric AcidN-AcetylcadaverineP-chlorophenylalanineLPE(0:0/20:2)LPC(O-14:1)LPC(0:0/18:1)LPE(18:1/0:0)Vitamin D3Tyr-Ser3,4-Dimethoxycinnamic acid8-AzaguanineN-Acetyl-L-methionineS-Adenosyl-L-MethionineUrobilinogen3-Oxocholic acidO-Phospho-L-tyrosine3-MethylxanthineSebacate3-Epideoxycholic acid2-AminomethylpyrimidineChaps4-acetoxyphenolHexadecanedioic acid2-Methyl-4-pentenoic AcidBiliverdin3-Amino-2-piperidinone(¡À)17(18)-DiHETE2,4-Di-tert-butylphenolFFA(17:0)Xylose3-N-Methyl-L-Histidine(¡À)19(20)-EpDPE(A)1-MethylguanineUridineLPE(20:4/0:0)(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoic acidMalonic acidN-AcetylthreonineDulcitol2,5-Dihydroxybenzoic acidIsoxanthopterinTestosterone sulfateLPE(22:6/0:0)N-Acetyl-L-tryptophanamideCarnitine C9:DCDiethanolamineLPC(0:0/16:2)5-F2t-IsoPGly-HisThiamine2,4-Pyridinedicarboxylic acidN-Methyl-¦Á-aminoisobutyric acidIle-SerPhosphatidylethanolamine lyso alkenyl 16:01,6-anhydro-¦Â-D-glucose12,13-DiHOMEAlloseHis-Ile3-Iodo-L-TyrosineL-TyrosineSubericacidArgininosuccinic acidSulfoacetic acidL-Asparagine Anhydrous3-Hydroxycinnamic acidPhe-ProN6-(2-Hydroxyethyl)adenosine3-Hydroxybutanoic acidSucroseTerephthalic AcidMannoseGlucoseN6-Acetyl-L-LysineFFA(15:1)D-Glucaro-1,4-lactoneLPC(O-16:0)SpermidineCortexoloneTriethylamine1-acetylindole2,6-Di-tert-butyl-4-(hydroxymethyl)phenolLeu-AlaLPC(0:0/16:0)PC(O-1:0/O-16:0)3-(imidazol-4-yl)propionic acidFolinic acid2-Dodecylbenzenesulfonic acid1-Hydroxy-2-NaphthoateIle-His2-Methyllactic acidLPC(O-16:1)LPC(0:0/16:1)LPC(12:0/0:0)Thr-GlnVanillylamineAMC Arachidonoyl Amide2-hydroxyhexadecanoic acidL-lyxose3-Methoxycatechol3-Indole carboxylic acid glucuronideOctadecanamideRitalinic acidCarnitine C2:0Creatine phosphateFFA(15:0)ButylamineMG(0:0/16:0/0:0)(¡À)-Camphoric acidPimelic acidLPS(18:0)2,2-Dimethylpentanoic acidCyclamic acidTert-ButylhydroquinoneGlycolithocholic acidVal-Asp(¡À)7(8)-DiHDPE(A)Thr-GluLPA(16:0/0:0)Gamma-Mercholic AcidCyclo(Phe-Pro)7-ketolithocholic acidLPG(0:0/18:2)TheobromineCortisolMethylparabenVal-ArgLPE(20:3/0:0)Urobilin2-BenzylmalateLeu-LeuAcetaminophen sulfateBetaineL-Ascorbyl 6-palmitateL-AlanineLPE(O-18:2)Asn-SerPalmitoylethanolamide£¨PEA£©16-HydroxyestroneNorethindrone acetateN-(3-Indolylacetyl)-L-alanineLPE(22:4/0:0)1-Aminocyclopropane-1-carboxylic acidCarnitine C12-OHPro-Ser2-FuroylglycineIndole-3-lactic acidIsoquinolineDL-2-hydroxystearic acidConiferolPhenoxyacetic acidCarnitine C18:1:2DCAzelaoyl PAF2-Carboxybenzaldehyde4-Hydroxytryptamine1-MethylhistidineGenipinN-Phenylanthranilic acid2-Aminoethanesulfinic AcidN-Myristoylglycine¦Ã-Aminobutyric AcidArg-IleVal-LeuLPC(17:0/0:0)3-methyl-4-pentenoic acidLeu-ArgN-MethylalanineS-methyl-L-thiocitrullineLPC(0:0/14:0)Glycocholic AcidCarnitine C5-OHHyodeoxycholic acidLPC(16:2/0:0)ST-638cyclo(pro-pro)ProgesteroneLactic acidPhe-HisLPC(0:0/14:1)AllantoinIle-Asp1-Aminopentadecane4-Amino-3-hydroxybutyric acidIle-AsnCarnitine C7:1Ethylsalicylate4-(Hydroxyamino)quinoline 1-oxidedihydrotachysterolL-HomoserineSPH(d16:1)6-Diazo-5-oxo-L-norleucine2-Hydroxyadipic acid10-Hydroxystearic AcidPhe-TrpTaurochenodesoxycholic AcidUridine triphosphate (UTP)3-Hydroxy-L-phenylalanineLPC(18:3/0:0)Indole-5-carboxylic acidCys-Arg1-Aminocyclohexanecarboxylic acidTetraethylene-glycol2'-DeoxyinosineGuanidineacetic AcidN-lactoyl-phenylalaninePorphobilinogenTyrosolN-oleoyl-L-serineLeu-ThrGemfibrozil2,4-DihydroxypyridineN¦Á-Acetyl-L-glutamineAcetaminophen Glucuronide(¡À)9-HETELactuloseMethyltrienoloneRhapontigeninTrimethylamine-N-OxideN-FormylglycineCarnitine C13:1LinoleamideCarnitine C13:0L-NorleucineD-Alloisoleucine3-Methyladipic acidalpha-Methyl-m-tyrosine5,6-DimethylbenzimidazoleN-Acetyl-D-GlucosamineGlu-Glncyclo(gly-glu)D-Xylulose 5-phosphateL-Homoarginine7-ketodeoxycholic acid9-oxoODECycloleucinePhe-LeuLPE(0:0/15:0)L-HomocitrullineCarnitine C24:5HeterodendrinCys-ProGlu-Gly6-O-methylguanineHexanoyl GlycineIle-Pro-IleCarnitine C9:1Carnitine C9:0Carnitine C4:DC2-Deoxy-D-ribofuranose 5-phosphate4-Ethyloctanoic acidLXB4Citric Acid18¦Â-Glycyrrhetinic acidMethylstearateIle-Leu5'-Deoxy-5'-(Methylthio) AdenosineLPE(18:3/0:0)2-Acetyl-5-methylfuranSer-Val2,6-XylenolAdipic AcidLys-Ala16-Dehydroprogesterone(¡À)12-HEPE3-keto PetromyzonolAsn-HypHypoxanthineProstaglandin A1 ethyl esterN6-methyladenosineGly-Trp2,6-Pyridinedicarboxylic acidL-Argininecis-CitralLeu-PheLPE(18:2/0:0)EthylazineN-acetyl-D-Lactosamine11-Carbonyl-beta-acetyl-boswellic acidPhe-AspCarnitine C12:1-OHArabinosePhe-Asn3-Methylequuric acid2,6-Diamino-5-hydroxyhexanoic acidL-Cysteinecyclo(glu-glu)N6,N6,N6-Trimethyl-L-lysineL-Gulose5-HydroxyindoleTriethylene glycol-monomethyl ether5-MethyluridineOxindoleLY223982Caftaric acidFFA(11:0)AdenineGlu-IleLythramineCortisoneGly-PheCarnitine C22:32-Deoxyribose 1-Phosphate2-Amino-5-methyl-4-phenylthiazole4-Acetylaminobenzoic acidL-SerineFurfural diacetalCarnitine C22:4Ile-ArgLumichromeN-Tetradecanoyl-L-homoserine lactone2-PyrrolidinoneLeu-Ile10-deoxyformamycinN-acetyl-D-phenylalanine2-Pentyl-3-phenyl-2-propenal3,4-Dimethylbenzoic acidLPC(18:2/0:0)Cholic acidPregnenoloneLPE(14:0/0:0)LPE(16:0/0:0)2-Methylhexanoic acidLys-Gly20beta-DihydroprogesteroneAla-Glu5-Aminovaleric AcidEllagic acidUreidosuccinic acid3-Hydroxy-3-Methyl Butyric AcidCaffeine(1R,6S)-6-amino-5-oxocyclohexyl-2-ene-1-carboxylic-acid-esterPyridine-3,4-dicarboxylic acid4-Hydroxy-3-methoxyphenylacetic acidN-Methyl-L-Glutamate4-tert-OctylphenolMethyl Indole-3-AcetateL-Methioninealpha-CEHC(¡À)12-HETEN-Amidino-L-AspartateN-AcetylhistamineMethyldopaNicotinamide2-Hydroxycaprylic acidLPE(17:1/0:0)Ile-AlaColneleic acidTheophylline6-Aminocaproic Acid2-Hexadecanoylthio-1-ethylphosphorylcholineCyclo(Pro-Val)Bovinic acidLys-ThrN-AcetylornithineSalidroside3-Hydroxy-3-Methylpentane-1,5-Dioic Acid6-Hydroxyflavone (6-HF)AcrylamideSer-Phe-AlaPyroglutamic acidMannitolCarnitine C17:1Carnitine C17:0CyclocreatinePyridoxamineMenadiol-DiacetateAsp-IleIndirubin 3'-monooximeLPC(17:1/0:0)4-MethoxysalicylaldehydeElenaic acidQuinic acid¦¢-Pseudouridine20,26-dihydroxyecdysoneMethyl-cinnamateN-Acetyl-L-Glutamic Acid2-Hydroxybutanoic AcidN-Acetyl-L-alanineL-Norvaline7-(alpha-D-glucosyl)-N(6)-isopentenyladenineAcetylcholineCyclo(Phe-Glu)Val-LysCarnitine C15:1:DCPhenyl acetateLeu-GluPC(12:0/12:0)Hyp-ThrGlu-ThrFFA(18:4)5-Acetylamino-6-formylamino-3-methyluracilEicosanoyl-EAIndole-3-acetamideLPC(O-20:2)Piperitone2-Methyl-5-nitroimidazole-1-ethanolLPA(20:5)Malic acid3-Oxododecanoic acidL-tyrosine methyl ester 4-sulfateN,N-DimethylarginineLPC(22:6/0:0)ZerenoBenzaldehydePhe-Ala-LeuMaltoseFFA(18:5)LPA(0:0/18:2)Gly-ProKojibioseN-Acetylneuraminic Acid(SA)Cyclo(Pro-Phe)2,6-Diaminopimelic acidLPC(O-20:3)Nicotinic Acid4-Aminomethylpyrimidine6-DimethylaminopurineLPA(20:4)Pyruvic AcidOxypurinolPhe-Phegamma-CEHCTaloseLPC(14:0/0:0)PterineHexadecanamideCAY-10550D-GlucuronolactoneLPA(0:0/18:1)MeleagrinFFA(18:2)Gly-TyrO-Acetyl-L-homoserine5-chloroindole-2-carboxylic acid2-Amino-2-methyl-1,3-propanediolMedroxyprogesteroneCarnitine C15:12-amino-6-oxohexanoic acid12-HHTPyrrolidineGlu-CitCyclopentylglycineIndole-3-phosphateEpinephrineAsp-Val2,22-Dideoxy-3-dehydroecdysoneTriethyl-phosphate2-Butyl-3-(4-hydroxybenzoyl)benzofuranImidazoleacetic acid2',4'-Dihydroxyacetophenone11-deoxy-16,16-dimethyl-PGE2Carnitine-2-methyl-C4Tartaric acidFFA(18:3)3-Amino-5-hydroxybenzoic acidDeoxycholic acidN1-AcetylsperminePhenylhydroxylamineErythruloseGlycodeoxycholic acidPhe-AlaLeu-GlyCMPFN-acetyl-beta-alaninefalseSerum Proteomic and Metabolomic Profiling of Sepsis Patients Reveals a Diagnostic Model and Mechanistic Insights into Carbapenem-Resistant Klebsiella pneumoniae Infection<p>Serum Proteomic and Metabolomic Profiling of Sepsis Patients Reveals a Diagnostic Model and Mechanistic Insights into Carbapenem-Resistant Klebsiella pneumoniae Infection</p>2026-05-182026-03-10MTBLS14016