MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14056/m_MTBLS14056_total.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14056/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14056/a_MTBLS14056_LC-MS_negative_hilic_metabolite_profiling.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14056/s_MTBLS14056.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14056/a_MTBLS14056_LC-MS_positive_hilic_metabolite_profiling.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14056<p>Metabolite annotation was performed using an R package combined with the BiotreeDB database (version 3.0), based on accurate mass and, where available, MS/MS fragmentation matching. Annotated metabolite lists and feature tables were exported for downstream analysis and interpretation.</p>MetaboLightsPublicLiquid Chromatography MS - positive - hilicLiquid Chromatography MS - negative - hilic<p>Polar metabolites were separated using a Vanquish UHPLC system (Thermo Fisher Scientific) equipped with a Waters ACQUITY UPLC BEH Amide column (2.1 mm × 50 mm, 1.7 µm; HILIC). Mobile phase A was 25 mM ammonium acetate and 25 mM ammonia hydroxide in water (pH 9.75), and mobile phase B was acetonitrile. The autosampler temperature was maintained at 4 °C and the injection volume was 2 µL. (Gradient program and flow rate followed the service provider’s standard method.)</p>Micro(nano)plastics in the development of myocardial fibrosis: from clinical detection to molecular mechanism.Beijing Anzhen HospitalYilin PanLeft Atrial Appendagemass spectrometry assay<p>Approximately 25±1 mg human left atrial appendage tissue was extracted with 500 µL methanol:acetonitrile:water (2:2:1, v/v) containing deuterated internal standards. Samples were vortexed (30 s), homogenized (35 Hz, 4 min) and sonicated (4°C water bath, 5 min) for three cycles, then incubated at −40°C for 1 h and centrifuged.</p>Homo sapiens<p>Raw LC–MS data were converted to mzXML format using ProteoWizard. Converted mzXML files were processed using an in-house R-based pipeline incorporating XCMS for peak detection, retention-time alignment, and peak integration to generate the feature intensity matrix. Features were filtered by relative standard deviation (RSD) de-noising. Missing values were imputed with half of the minimum detected value, and peak intensities were normalized using the internal standard method. The processed data matrix was used for downstream statistical analyses.</p>Nanoplasticshttps://www.ebi.ac.uk/metabolights/MTBLS14056pyldudu@outlook.com<p>Left atrial appendage was obtained as specimens before initiation of cardiopulmonary bypass and surgical ablation. Sample collection was performed by trained research staff wearing cotton surgical scrub suits and rubber surgical gloves near the operating table. The tissue was frozen in liquid nitrogen and stored at -80°C for downstream molecular analyses. All samples were collected following standardized surgical procedures, ensuring patients were not exposed to any additional harm.</p>MetabolomicsMyocardial fibrosismicro(nano)plasticuntargeted metabolite profilingMyocardial fibrosismicro(nano)plasticuntargeted metabolite profiling<p>Mass spectrometry was performed on an Orbitrap Exploris 120 mass spectrometer (Thermo Fisher Scientific) with an electrospray ionization (ESI) source, operating in positive and negative ion modes (separate acquisitions). Data were acquired under Xcalibur software in information-dependent acquisition (IDA) mode (full-scan MS with data-dependent MS/MS). Source conditions were: sheath gas 50 Arb, auxiliary gas 15 Arb, capillary temperature 320 °C, spray voltage +3.8 kV (positive) and −3.4 kV (negative). Full-scan MS resolution was 60,000 and MS/MS resolution was 15,000, with normalized collision energy (NCE) 20/30/40.</p>S-AdenosylmethioninamineCaprolactamPhenylacetylglutamineMangiferdesmethylursanonePC(14:1(9Z)/16:0)Cefuroxime4-Cresol sulfateEctoineCoumestrolVal-MetPantothenolL-ErythruloseAltretamineKetoleucineTacrineCholest-4-en-26-oic acid, 7alpha-hydroxy-3-oxo(25S)-26-Hydroxy-24-methylenecycloartan-3-oneCaplaminNipecotic acidPC(18:4(6Z,9Z,12Z,15Z)/P-16:0)ValdecoxibScopoletinGlyzaglabrin1-KestoseCapric acidPC(20:3(5Z,8Z,11Z)/15:0)1-Hydroxy-2-naphthoic acidD-Glucosaminic acidcis-?9,?10-?Epoxystearic acid4-HydroxybenzaldehydePicolinamideN2-AcetylornithineAdenosine 5'-triphosphate (ATP)1H-Indole-4-carboxaldehyde1-O-beta-D-Glucopyranosyl-2,3-di-O-(8-hexadecenoyl)glycerolMevalonic acidArginine[12]-GingerolPC(16:0/18:0)Glutathione4-Hydroxyglutamic acidPC(16:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))Piperonylic acidTetrabenazineMaltopentaoseDeoxyguanosine triphosphate (dGTP)IsodesmosineGalactono-1,4-lactonePro-GlyDioscinIsradipineKainic acidN-Methyl-L-prolineN-Acetylneuraminic acidMoxonidinePantothenic acidEtodolacHygric acidLeu-Val1-O-Hexadecyl-sn-glycero-3-phosphocholine (LPC(O-16:0/0:0))Erythrose 4-phosphate3-NitrophenylhydrazineAcetylglycineHEPTANOIC ACIDMono(2-ethylhexyl) phthalateProlylalanineDienestrol diacetateHomoarecolineMetoprolol acid12'-Apo-b-carotene-3,12'-diolMethylguanidineAsparaginyl-ValineChenodeoxycholic acidOrnithineN-Acetyl-D-glucosamine 6-phosphatePS(18:0/18:2)CarbidopaEvocarpineDecadienoylcarnitineSerine4-Methyl-5-vinylthiazolecis-11.14-Eicosadienoic acidLysoPC(22:5(7Z,10Z,13Z,16Z,19Z))LPE(P-16:0)risedronate(3beta,5alpha,6beta,22E,24R)-23-Methylergosta-7,22-diene-3,5,6-triolPromethazine sulfoxidePhenylsulfateIsocitric acidTiaprostTyr-GlyTetradecyl sulfate (sodium)N-LauroylglycineAdenosinePC(16:0/18:1(9Z))L-beta-aspartyl-L-threonineDiphenhydramine (hydrochloride)N-acetyldopamineAllopurinolUric acidPIPESPro-IleL-tyrosine-methyl-esterLinoleic acidPC(18:0/18:3(6Z,9Z,12Z))OccidentosideGlucitolAdenosine 3',5'-diphosphate (PAP)MOXIFLOXACINO-Methyl-DL-serine3-Hydroxybutyric acidBetonicineBenzoic acidLysoPE(22:5(7Z,10Z,13Z,16Z,19Z)/0:0)5-MethylcytosineMethylsuccinic acidN-Acetylneuraminate 9-phosphateGlycolithocholic acid 3-sulfatePC(20:2(11Z,14Z)/18:1(9Z))DalfopristinSedoheptulose 1,7-bisphosphateO-AcetylserineEcgoninePC(16:0/16:0)SphingosineMinocyclineChlorhexidineCalcimycin1-Hydroxy-3,5-dimethoxy-2,4-diprenylxanthoneCarbendazim6-FormylpterinThreonine2-Deoxyribose 5-phosphate2-Ketobutyric acidIsodeoxycholic acidEcabet (sodium)NitrofurazoneLysineSM(d18:1/17:0)CyclobenzaprineLinoleoylcarnitineMelibiitolDesethylchloroquineTrehalosealpha-Ketoglutaric acid (alpha-KG)cis-4-Decenoylcarnitine2-O-MethylcytosinePE(20:2(11Z,14Z)/14:1(9Z))GuanineSM(d18:0/18:0)(R)-6'-O-(4-Geranyloxy-2-hydroxycinnamoyl)-marmin2-Naphthol(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate (SAICAR)Prostaglandin I2 (PGI2)1-MethylnicotinamideLysoPE(22:4(7Z,10Z,13Z,16Z)/0:0)PC(18:1(9Z)/18:0)Prednisolone2-Hydroxyoctanoic acid1-(2-Thienyl)-1-heptanoneN-[2-(1H-Indol-3-yl)ethyl]docosanamideProlintaneCysteine-glutathione disulfide3-Methyl-2-oxovaleric acidMannose 1-phosphateCitric acidGlycylleucine7-Methylguaninecis-9-Palmitoleic acid1-Phenyl-1,3-nonadecanedione8-iso-15-keto-PGE25,6-Dihydrouridine6-AcetylcodeineHydroxyisocaproic acidGlutathione disulfideMepirizoleNadololTauroursodeoxycholic acidSM(d18:0/16:0)Inosine 5'-monophosphate (IMP)Glycocholic acidPC(20:2(11Z,14Z)/20:5(5Z,8Z,11Z,14Z,17Z))Pipecolic acidPhe-ValRanolazineGlucose 6-phosphate1-MethylpiperazineAdenosine dialdehyde2'-DeoxyuridineIndole-3-carboxaldehyde1,4-IpomeadiolStearic acidSakuranetinPC(38:5)Nitrilotriacetic acidChloramphenicolGlutamateSulfanilamideCarnitinexi-2,2,6-Trimethyl-1,4-cyclohexanedioneDyphyllineAmericine2-Amino-4-nitrophenolMESDL-Isocitric acid lactoneLPC(16:0)Taurochenodeoxycholic acidAVOCADYNEAG 1295(22E,24R)-Stigmasta-4,22-diene-3,6-dioneTrimethylamine N-oxideN-StearoyltaurinePC(14:1(9Z)/18:2(9Z,12Z))5-(Galactosylhydroxy)-L-lysineAlanylalanine (Ala-Ala)Isobutyrylcarnitine (Car(4:0))N6,N6,N6-TrimethyllysinePC(38:3)Fluoxymesterone2,5-Dihydro-2,4,5-trimethyloxazolePI(16:0/18:1)ThyminesuberosinPelargonic acidCyproterone3-MethylhistaminetaxifolinD-RiboseTrolox4-HydroxyisoleucineSarcosineHeptanoylcarnitineGalactoserubiadinmolluginPC(38:4)16-Hydroxypalmitic acid1-MethylhistamineTaurineZalcitabineCar(18:1)Probucol2-Aminonicotinic acidO-PhosphoethanolamineBenzenesulfonic acidMannose 6-phosphate10-methylacridone4-Chloro-2-methylphenolTrifluoroacetic acidPirbuterol2-Hexaprenyl-6-methoxyphenolPC(22:5(7Z,10Z,13Z,16Z,19Z)/24:0)SUXIBUZONEDapsone hydroxylamineAgmatineSph(d18:0)PE(18:1(9Z)/18:2(9Z,12Z))acetohexamideDiclofensineMebeverineGanoderic acid HTrifolirhizinPi-Methylimidazoleacetic acid (hydrochloride)Danazol17alpha-HydroxypregnenoloneGanoderic acid BGanoderic acid APC(18:1(11Z)/15:0)trans-Vaccenic acidPC(20:5(5Z,8Z,11Z,14Z,17Z)/P-16:0)4-Chlorophenol7-MethylguanosinePE(P-18:1(11Z)/22:4(7Z,10Z,13Z,16Z))PC(37:5)1-MethylguanosinePC(18:1(9Z)/P-16:0)N-[(Ethoxycarbonyl)methyl)-p-menthane-3-carboxamideIditolACARBOSEPenicillin GFructose 1-phosphate3-Hydroxyvaleric acid2-Aminobutyric acidVal-IleDinor-12-oxophytodienoic acidMinaprine (dihydrochloride)PI(18:1/18:1)Harmanine6-Thioinosine-5'-monophosphateDehydroacetic acidPS(18:1(9Z)/20:1(11Z))PC(16:0/16:1(9Z))DopaminePhenylalanineSph(d18:2)Car(18:0)ErythromycylaminePyrazinamideProlylhydroxyprolineBenzoylcarnitinePentaethylene glycolPersicachromeCDP-glycerolUracilEicosapentaenoic acidOxooctanoylcarnitineDifloxacinAzithromycinOctenoylcarnitineCreatineAS057278Isoniazid alpha-ketoglutaric acid5-Aminolevulinic acidCaprylic acidL-2-Aminoadipate adenylateMaravirocSM(d18:1/18:0)CytosinePG(18:1(11Z)/18:1(9Z))FerulateCiprostene2-AcetylthiazoleCarebastinePro-PheEthosuximideXanthopterinN2,N2-Dimethylguanosine5-Hydroxypyrazine-2-Carboxylic AcidTryptophyl-Methionine3-Hydroxylauric acidOxalic acidN,N-Dimethylarginine (ADMA)PehanormMethylgallate2'-Deoxyguanosine 5'-diphosphate (dGDP)5-HydroxyisouratePE(P-36:4)3-HydroxysintaxanthinPimonidazoleStatineN-Acetylmuramoyl-AlaPimozideHypaphorineVal-Val(2S)-4-amino-2-[(azaniumylacetyl)amino]-4-oxobutanoateBendamustineLPC(18:0/0:0)2-PropanoylthiazoleUDP-N-acetylglucosamineVaccinosideIsoleucineGlycohyodeoxycholic acidHarmaline2-Methyl-3-hydroxybutyric acidArachidonic acid (AA)PyruvateN-Lactoyl-PhenylalanineThreonic acidNeotameFructose2,2'-Iminodiacetic acidHeptadecanoic acidDoxycyclineCitraconic acidDehydroascorbic acid (Oxidized vitamin C)PC(14:0/P-18:1(9Z))AmobarbitalCytidine 5'-diphosphocholine (CDP-choline)DimethylglycineGlutamine1,2-DimethylimidazoleMOPS3-[4-Hydroxy-3-(3-methyl-2-butenyl)phenyl]-2-propenalTriclabendazolePhenylacetic acidCaproic acidDihydroxyacetone phosphateMerafloxacinThiamine pyrophosphate (TPP)Palmitic acidsn-Glycerol 3-phosphateRaltitrexedHistidinePA(19:0/20:0)cis-5-TetradecenoylcarnitinePhosphonoacetateTyraminePalmitoylcarnitine (Car(16:0))L-CitrullinePropionic acidAllopurinol-1-ribonucleosidePE(14:0/22:5(7Z,10Z,13Z,16Z,19Z))Glyco-beta-muricholic acidAmlexanoxPropionylcarnitine (Car(3:0))Cortisone acetateGly-Val4'-HydroxywarfarinOctanoylcarnitine (Car(8:0))PC(35:3)Ser-AlaDocosahexaenoic acid (DHA)GatifloxacinMelezitosePG(18:0/16:1(9Z))BifemelaneGlycerophosphocholineAzetidine-2-carboxylic acidErgothioneinealpha-HederinVarenicline3-Methoxy-4-hydroxyphenylethyleneglycolHexenoylcarnitineFormylmethioninePropazineThr-LeuIndoleacetic acidHydroxyphenylacetylglycine3-Hydroxyoctanoic acidKynurenineDiethylcarbamazineSM(d17:1/24:1(15Z))EdaravoneHydroxyphenyllactic acidLeucyl-CysteineN-LactoylphenylalanineAdenosine 3',5'-cyclic phosphate (cAMP)L-Alanyl-L-leucineAlanine2-Methylguanosinegamma-GlutamylglutamineN-AcetylhistidineLevulinic acidAristolodioneGlutamylalanineTryptophanPG(18:1/18:1(9Z))Mannitol 1-phosphateMeprobamateXanthineFructose 6-phosphate(+/-)-2,8-Epithio-cis-p-menthaneCholinePC(16:0/20:4)N,N'-Diphenyl-p-phenylenediamineAsparagineAvasimibeLeucylphenylalanine4-HydroxychalconeTridecenoylcarnitineRhusflavanone2-MethylundecanalArg-PhePG(16:0/18:1)4-DimethylaminopyridineS-Methylmethionine5-HydroxymethyluracilAldosteroneDG(18:3(6Z,9Z,12Z)/15:0/0:0)N-Carbamoylsarcosine3-Hydroxypyruvic acidMaleic acidAdenosine monophosphate (AMP)3'-DeoxyoleaceinGluconic acidAzomycino-Tyrosine2-Aminopurine3-Amino-4-methylpentanoic acidIndoxyl sulfateGlufosinatePG(16:0/18:0)PhosphorylcholineN1-Methyl-2-pyridone-5-carboxamideVal-GlyS-AdenosylhomocysteinePC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/P-16:0)2-Methoxy-3-methyl-9H-carbazole2-Hydroxy-2-methylbutyric acidHMMNIHexanoylcarnitine (Car(6:0))sn-Glycerol 1-phosphateIsonicotinamidePyruvaldehydeEpigallocatechin2-Oxoadipic acidGemcitabine3-Hydroxystigmast-5-en-7-onePhthalic anhydrideLeucineDihydrothyminePiperidinePiperlongumineLacto-N-triaoseArg-Ala2-Linoleoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamineLPI(18:0)Xylitol3-Hydroxy-N6,N6,N6-trimethyl-L-lysineLactoseBiotinyl-5'-AMP2'-Deoxyguanosine 5'-monophosphate (dGMP)1,7-DimethylxanthineLPC(20:4)Acamprosate (calcium)Thr-PhePhosphoglycolic acidRamiprilMeAIB3,3-Dimethylglutaric acidProlyl-TyrosineLimoninCephalosporin CDeoxyinosinecis-Melilotoside2-Ketocaproic acidThiolutinNicotinate D-ribonucleosideCMP-2-aminoethylphosphonatebeta-CarbolinePhysapubescinIsomaltPhenolEnoxacin (hydrate)Syringic acidNicotinamide adenine dinucleotide phosphate (NADP)N-Acetylaspartic acidMesaconic acidPE(P-18:1(9Z)/20:5(5Z,8Z,11Z,14Z,17Z))L-FucitolGlucosamine7-Hydroxy-3-oxo-cholest-4-en-26-oic acidArabinono-1,4-lactoneGlycinelactitolPC(20:3(5Z,8Z,11Z)/14:0)Glu-ArgOleic acidGlutaric acidIMIPRAMINEAscofuranonePropafenoneAdenylsuccinic acid(3beta,23E)-3-Hydroxy-27-norcycloart-23-en-25-oneastilbinDMPOPseudouridineButyrylcarnitine (Car(4:0))PC(18:3(6Z,9Z,12Z)/15:0)Terephthalic-AcidCapsazepinePC(P-34:0)Ginkgolide APC(18:0/14:0)PS(20:3(8Z,11Z,14Z)/20:1(11Z))LysoPE(16:1(9Z)/0:0)2-Hydroxypalmitic acidTridecanoylcarnitinePC(16:0/P-16:0)ThiaclopridLysoPE(22:0/0:0)3-HydroxyhexadecanoylcarnitineSM(d18:1/24:0)Tyrosylalanine5,6-DihydroxyindoleGuanosineBisdemethoxycurcuminRibothymidine3-Hydroxydecanoic acidPC(15:0/20:1(11Z))3-Oxocholic acidLysoPC(18:1(11Z))MesotrioneGlyceric acidMethyl beta-D-glucopyranosideTebuconazoleBiliverdin2-Aminoisobutyric acidPC(14:1(9Z)/P-16:0)GDP-4-dehydro-6-deoxy-D-mannoseXylosePalmitoyl sphingomyelinPC(18:0/16:0)KINETINPC(10:0/10:0)L-Thyronine1-MethylguaninePyrophosphateUridineCalcipotriol8-Acetylegelolide2,2'-DithiodipyridinePindolol4-Hydroxyphenylacetaldehyde1-oleoyl-2-myristoyl-sn-glycero-3-phosphocholine8-HydroxymianserinMalonic acid2-HydroxyadenineProlinePC(18:2(9Z,12Z)/15:0)Valyl-Proline3-SulfinoalanineChlorambucilNelarabineDecanoylcarnitine (Car(10:0))BeclomethasonePyroquilonProlyl-ValineGlutarylcarnitine3-NitrotyrosineFomesafenMalonyl-CoAGly-HisThiamineProbenecidN-OxalylglycineNomifensineFructose 2-phosphateGalactitolGlycoursodeoxycholic acidChenodeoxycholic acid 3-glucuronidePC(18:1(9E)/18:1(9E))Glucitol 6-phosphatePC(15:0/14:1(9Z))ChlordiazepoxidePhe-Lys2,4-Dihydroxybutanoic acidIsoquercitrinHomogentisic acidPE(P-18:0/22:4(7Z,10Z,13Z,16Z))SM(d18:0/20:0)SulfamerazineCyclic adenosine diphosphate-ribose (cADPR)Fumaric acid4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanoneArgininosuccinic acidThelephoric acidHypotaurine10,13-dimethyl-17-oxo-3-sulfooxy-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrenePhe-ProSucroseDaltogenGlucoseDodecyl gallateN6-Acetyllysine8-Isobutanoylneosolaniol2-AminonaphthaleneTaurocholic acidPC(40:6)SpectinomycinUrocanic acidRibitolAspartylphenylalanineN-Formyl-L-aspartateEntacaponeOlodaterolTolmetinCurcumenolOctanolNicotinamide adenine dinucleotide (NAD)2-Amino-5-phenylpyridineCeftriaxoneTetraethylene glycol4-(Hydroxymethyl)benzenediazonium(1+)LPS(18:1)5'-MethylthioadenosineOxacillinHydroxyacetoneCer(d18:1/16:0)DEHPZoniporideMianserinAlfacalcidolCreatinineEthylphosphonic acid4-Methoxy-5-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,3-benzenediolDEOXYRIBOSEAspartateGuanosine 5'-diphosphate (GDP)2,2-Dimethylsuccinic acidAdenosine 2',3'-cyclic phosphate6-Phosphogluconic acidLPS(18:0)CyproheptadineVerbasosideCefazolin5-Aminopentanoic acidValineStachydrineTiglylcarnitine (Car(5:1))3-Deoxy-D-glycero-D-galacto-2-nonulosonic acidDimethadioneMardepodectHexaethylene glycolDictamnineDeoxycholic acid 3-glucuronidePE(P-18:1(11Z)/20:5(5Z,8Z,11Z,14Z,17Z))Theobromine1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamideUrobilingamma-GlutamylvalineLeu-Leu5-Fluorouridine2-(Phenylethenyl)-1,3-dioxolaneLuminolHarmolCer(d18:1/18:0)DaminozideLotaustralin2-Hydroxy-3-methylbutyric acidGlyco-gamma-muricholic acidCytidinebeta-CryptoxanthinSuccinamideIsoquinolinealpha-C-MannosyltryptophanLPE(14:0)5-Methyl DL-glutamateH-Val-Ala-OH3-(2,3,4-Trimethoxyphenyl)propanoic acid1-MethylhistidineDodecanoic acidIsoleucyl-Threonine10-Hydroxydecanoic acidPC(18:1(9Z)/18:1(9Z))3-Hydroxybutyrylcarnitine (Car(4:0-O))LPC(17:0/0:0)GlycerophosphoethanolamineCadaverineMetoprolol2-Hydroxyethanesulfonic acidOfloxacin N-oxide2-NaphthalenethiolGlycochenodeoxycholic acidClofarabine13(S)-HODEN2-(3-Hydroxysuccinoyl)arginineHyodeoxycholic acidTetradecadienoylcarnitineN-AcetylalanineDichlorprop2-MethylbenzoxazoleLysoPE(0:0/18:0)EmbelinPE(P-18:0/18:1(9Z))3,4-Dihydroxyphenylacetic acid1,5-AnhydroglucitolBistris2-methylcitrateSM(d18:1/20:0)SyringinRiluzolePralidoximeTandutinibPS(15:0/20:3(8Z,11Z,14Z))5-Hydroxyvalproic acid5-HydroxytryptophanAdenosine 3'-monophosphatebeta-Alanine2,3-Dihydroxy-2-methylbutanoic acidPhe-TrpNetilmicin1-MethylpyrrolidineMonoethylglycinexylidide (MEGX)N-AcetylcarnosineEtofyllineMethionineSinapineNalbuphineLauroylcarnitine9-Oxooctadecanoic acidFostriecinBrinzolamide4-HydroxyprolineCholesteryl sulfateGabapentinIsovalerylcarnitine (Car(5:0))Citrininalpha-ChaconineCarnosine3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dioneN-Formylglycinegamma-Glutamylglutamic acidTrierucinVigabatrinFlurtamonePhosphateHexamethylquercetagetinS-FormylglutathioneDihydromethysticinPentadecanoic acidAspirinGalactinolHydroxyprolyl-Proline3-Methyl-4-nitrophenolGuanosine 5'-monophosphate (GMP)20-DeoxynarasinPhe-LeuBisindolylmaleimide IFlurandrenolide(5alpha,8beta,9beta)-5,9-Epoxy-3,6-megastigmadien-8-olPipericineGlu-GluD-4'-PhosphopantothenateIndolelactic acidNorleucineRibulose 5-phosphate5-Hydroxytryptophol (5HTOL)MaltotetraoseAprobarbitalMesoporphyrin IXXanthotoxolTriethylene glycol monobutyl etherArachidonoylcarnitine (Car(20:4))OleoylcarnitineImidazol-1-yl-acetic acidFenpropimorphDimetridazole2-AcetylpyrazinematairesinolTyrosineIle-LeuAcetylcarnitine (Car(2:0))3-Ureidopropionic acid12-Methyltridecanoic acidPE(18:4(6Z,9Z,12Z,15Z)/P-18:1(9Z))BilobalideTaurocyamineHydroxychloroquineMyristic acidArabitolHypoxanthineHomoserinegamma-Linolenic acidFuraltadoneHippuric acidalpha-Linolenic acidRocuroniumLevallorphanPivagabineUridine 5'-monophosphate (UMP)LPE(18:1(9Z)/0:0)N-Acetylaspartylglutamate (NAAG)beta-Guanidinopropionic acidN8-AcetylspermidineMethocarbamolTauro-gamma-muricholic acidPC(20:3(5Z,8Z,11Z)/18:0)Glucono-1,5-lactone5-Hydroxyindole2-Hydroxybutyric acidPC(18:4(6Z,9Z,12Z,15Z)/20:3(8Z,11Z,14Z))Ophthalmic acidLPI(20:4)Phe-TyrS-(Hydroxymethyl)glutathione2-Ethyl-2-hydroxybutyric acidAdenineGlu-Val-PhezapotinTimonacicGly-PheDodecenoylcarnitineHydroquinidineAlloimperatorinInosinePurineLumichromeD-PhenylalanineCelerinMethylimidazoleacetic acidPC(22:4(7Z,10Z,13Z,16Z)/P-18:1(9Z))OuabainLeu-IleAdenosine 5'-diphosphate (ADP)LPC(18:2/0:0)HistidinolCarnosolAla-GlyPC(P-16:0/0:0)N-Acetylmethionine3-AMINO-2-PIPERIDONE1-Isothiocyanato-8-(methylthio)octaneCellobioseAla-GluPirimicarbMelibioseAnserineLysyl-GlycineSM(d16:1/24:1(15Z))(Dimethoxymethyl)benzeneAla-GlnMetharbital2-AminopyridineFlibanserinDexrazoxaneMaltotrioseValproic acidLeptomycin BAnagrelideCDP-EthanolamineN5-acetyl-l-ornithine5-HydroxypyrazinamideDihydrouracilTheaflavinRanitidinePE(18:4(6Z,9Z,12Z,15Z)/18:0)ISOPALMITIC ACIDNicotinamideL-Valyl-L-phenylalanineMetronidazoleTheophyllinePC(14:0/14:0)Ferulic acid 4-O-glucuronide7-Ketodeoxycholic acidTuranosePE(18:0/18:2)Picolinic acidDynasoremyo-InositolMannitolPyroglutamic acidGlucose 1-phosphateUridine 5'-diphosphate (UDP)Betaine aldehyde1-Myristoyl-sn-glycero-3-phosphocholine (LPC(14:0/0:0))DerenofyllineIsomaltosepomiferin4-Hydroxybenzyl cyanideEDTAPE(P-18:1(9Z)/20:4(5Z,8Z,11Z,14Z))S-AdenosylmethionineN-[3-(2-oxopyrrolidin-1-yl)propyl]acetamidePC(34:4)ADP-riboseDeoxyguanosineNylidrinS-Acetyldihydrolipoamide-EAllixin(+)-(1R,2R)-1,2-Diphenylethane-1,2-diolAcetylcholineTauro-beta-muricholic acidValerylcarnitineLactateSph(t18:0)6-KetoestriolThymidine2-Hydroxyhexanoic acidUrsodeoxycholic acidIsocaproic acidPantetheineMalic acid3-Phosphoglyceric acidProscillaridin APC(14:0/16:0)DocebenonePE(18:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))PC(15:0/22:4(7Z,10Z,13Z,16Z))BenzaldehydePyrimethamineCidofovirMaltoseTheanineBufalin3-Methyl-3H-imidazo[4,5-f]quinoxalin-2-amineProlyl-HistidineHistamine3-Hydorxy-3-methylglutaric acidFurcelleranOxypurinolAzathioprineRacanisodamine2-PiperidoneDiglycineSM(d18:1/22:0)N-Hydroxy-4-aminobiphenylProlyl-ThreonineFlunarizineTaurodeoxycholic acid1-Methylcytosine4-Aminobutyric acid (GABA)Azelaic acidProparacaine1-Isothiocyanatobutane1,3-DimethyluracilN1-Methyl-4-pyridone-3-carboxamidePyrrolidinecirsimaritinPE(22:2(13Z,16Z)/P-16:0)L-?Leucyl-?L-?alanineImidazoleacetic acid2,5-Furandicarboxylic acidalpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehydeDeoxycholic acidGanoderic acid DMGlycodeoxycholic acidMukolinePhe-AlaDaidzeinfalseNon-targeted LC–MS metabolomics of human left atrial appendage tissue with high vs low myocardial micro(nano)plastic burden<p>Non-targeted metabolomics profiling was performed on human left atrial appendage tissue obtained from cardiac surgery patients. Samples were grouped by myocardial nanoplastic (NP) burden (High vs Low). Polar metabolites were analyzed by UHPLC–Orbitrap MS in both positive and negative ionization modes. Derived spectral data are provided as mzXML files for each sample and polarity.</p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