MetaboLights

application/xml

ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14102/m_MTBLS14102_LC-MS_positive_reverse-phase_metabolite_profiling_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14102/m_MTBLS14102_LC-MS_negative_reverse-phase_metabolite_profiling_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14102/s_MTBLS14102.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14102/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14102/a_MTBLS14102_LC-MS_positive_reverse-phase_metabolite_profiling-1.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14102/a_MTBLS14102_LC-MS_negative_reverse-phase_metabolite_profiling.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14102The pretreatment of LC/MS raw data was performed by Progenesis QI software, and a three-dimensional data matrix in CSV format was exported. The information in this three-dimensional matrix included: sample information, metabolite name and mass spectral response intensity. Internal standard peaks, as well as any known false positive peaks (including noise, column bleed, and derivatized reagent peaks), were removed from the data matrix, deredundant and peak pooled. At the same time, the metabolites were identified by searching database, and the main databases were the HMDB (http://www.hmdb.ca/), Metlin (https://metlin.scripps.edu/) and the self-compiled Majorbio Database (MJDB) of Majorbio Biotechnology Co., Ltd. (Shanghai, China) The data matrix obtained by searching database was uploaded to the Majorbio cloud platform (https://cloud.majorbio.com) for data analysis. Fistly, the data matrix was pre-processed, as Your Personal Adviser of Life Science and Technology Services follows: At least 80% of the metabolic features detected in any set of samples were retained. After filtering, the minimum value in the data matrix was selected to fill the missing value and each metabolic signature was normalized to the sum. To reduce the errors caused by sample preparation and instrument instability, the response intensities of the sample mass spectrometry peaks were normalized using the sum normalization method, to obtain the normalized data matrix. Meanwhile, the variables of QC samples with relative standard deviation (RSD) > 30% were excluded and log10 logarithmicized, to obtain the final data matrix for subsequent analysis.Perform variance analysis on the matrix file after data preprocessing. The R package “ropls”(Version 1.6.2) was used to perform principal component analysis (PCA) and orthogonal least partial squares discriminant analysis (OPLS-DA), and 7-cycle interactive validation evaluating the stability of the model. The metabolites with VIP>1, p<0.05 were determined as significantly different metabolites based on the Variable importance in the projeciton (VIP) obtained by the OPLS-DA model and the p-value generated by student’s t test. Differential metabolites among two groups were mapped into their biochemical pathways through metabolic enrichment and pathway analysis based on KEGG database (http://www. genome.jp/kegg/). These metabolites could be classified according to the pathways they involved or the functions they performed. Enrichment analysis was used to analyze a group of metabolites in a function node whether appears or not. The principle was that the annotation analysis of a single metabolite develops into an annotation analysis of a group of metabolites. Python packages “scipy.stats” (https://docs.scipy.org/doc/scipy/ ) was used to perform enrichment analysis to obtain the most relevant biological pathways for experimental treatments.MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phaseThe LC-MS/MS analysis of sample was conducted on a UHPLC-Orbitrap Exploris 240 system equipped with an ACQUITY HSS T3 column (100 mm × 2.1 mm i.d., 1.8 μm) at Majorbio Bio-Pharm Technology Co. Ltd. (Shanghai, China). The mobile phases consisted of 0.1% formic acid in water:acetonitrile (2:98, v/v) (solvent A) and 0.1% formic acid in acetonitrile (solvent B). The flow rate was 0.40 mL/min and the column temperature was 40℃. The injection volume was 5 μL.Intercropping with Peucedanum praeruptorum enhances the growth and quality of Pseudostellaria heterophylla.Qing-Song YuanGuizhou University of Traditional Chinese MedicineRoot exudatesmass spectrometry assay100 mg solid sample was added to a 2 mL centrifuge tube and a 6 mm diameter grinding bead was added. 800 μL of extraction solution (methanol: water = 4:1 (v:v) containing four internal standards ( 0.02 mg/mL L-2-chlorophenylalanine, etc.) were used for metabolite extraction. Samples were ground by the Wonbio-96c ( Shanghai wanbo biotechnology co, LTD) frozen tissue grinder for 6 min (-10°C, 50 Hz), followed by low-temperature ultrasonic extraction for 30 min (5°C, 40 kHz). The samples were left at -20°C for 30 min, centrifuged for 15 min (4°C, 13000 g), and the supernatant was transferred to the injection vial for LC-MS/MS analysis.Hydroponic samplehttps://www.ebi.ac.uk/metabolights/MTBLS14102Qingsong Yuan. Guizhou University of Traditional Chinese Medicine. yqs198609031006@126.com.Chuanzhi Kang.Xue Jiang.Lingling Wang.Yanhong Wang.Tao Zhou. Guizhou University of Traditional Chinese Medicine. taozhou88@163.com.Jiayue Ran.Yanping Gao.Xiaohong Ou.Zan Li.Xianyan Xie. 3515895880@qq.com.Yangjun Tan.The pretreatment of LC/MS raw data was performed by Progenesis QI software, and a three-dimensional data matrix in CSV format was exported. The information in this three-dimensional matrix included: sample information, metabolite name and mass spectral response intensity. Internal standard peaks, as well as any known false positive peaks (including noise, column bleed, and derivatized reagent peaks), were removed from the data matrix, deredundant and peak pooled. At the same time, the metabolites were identified by searching database, and the main databases were the HMDB (http://www.hmdb.ca/), Metlin (https://metlin.scripps.edu/) and the self-compiled Majorbio Database (MJDB) of Majorbio Biotechnology Co., Ltd. (Shanghai, China) The data matrix obtained by searching database was uploaded to the Majorbio cloud platform (https://cloud.majorbio.com) for data analysis. Fistly, the data matrix was pre-processed, as Your Personal Adviser of Life Science and Technology Services follows: At least 80% of the metabolic features detected in any set of samples were retained. After filtering, the minimum value in the data matrix was selected to fill the missing value and each metabolic signature was normalized to the sum. To reduce the errors caused by sample preparation and instrument instability, the response intensities of the sample mass spectrometry peaks were normalized using the sum normalization method, to obtain the normalized data matrix. Meanwhile, the variables of QC samples with relative standard deviation (RSD) > 30% were excluded and log10 logarithmicized, to obtain the final data matrix for subsequent analysis.Perform variance analysis on the matrix file after data preprocessing. The R package “ropls”(Version 1.6.2) was used to perform principal component analysis (PCA) and orthogonal least partial squares discriminant analysis (OPLS-DA), and 7-cycle interactive validation evaluating the stability of the model. The metabolites with VIP>1, p<0.05 were determined as significantly different metabolites based on the Variable importance in the projeciton (VIP) obtained by the OPLS-DA model and the p-value generated by student’s t test. Differential metabolites among two groups were mapped into their biochemical pathways through metabolic enrichment and pathway analysis based on KEGG database (http://www. genome.jp/kegg/). These metabolites could be classified according to the pathways they involved or the functions they performed. Enrichment analysis was used to analyze a group of metabolites in a function node whether appears or not. The principle was that the annotation analysis of a single metabolite develops into an annotation analysis of a group of metabolites. Python packages “scipy.stats” (https://docs.scipy.org/doc/scipy/ ) was used to perform enrichment analysis to obtain the most relevant biological pathways for experimental treatments.Treatmentyqs198609031006@126.comAt July 1, 2024, fifty milliliters of P. heterophylla culture solution from hydroponic experiments were frozen in liquid nitrogen and lyophilized.MetabolomicsintercroppingphotosyntheticRoot exudatesuntargeted analysisHydroponic samplePseudostellaria heterophyllaMultiomicsPeucedanumUHPLC-Orbitrap Exploris 480pooled sampleAgilent 1100 Series HPLC SystemintercroppingphotosyntheticRoot exudatesuntargeted analysisHydroponic samplePseudostellaria heterophyllaMultiomicsPeucedanumUHPLC-Orbitrap Exploris 480pooled sampleAgilent 1100 Series HPLC SystemThe UPLC system was coupled to a UHPLC-Orbitrap Exploris 240 system Mass Spectrometer equipped with an electrospray ionization (ESI) source operating in positive mode and negative mode. The optimal conditions were set as followed: source temperature at 400℃ ; sheath gas flow rate at 40 arb; Aux gas flow rate at 10 arb; ion-spray voltage floating (ISVF) at -2800V in negative mode and 3500V in positive mode, respectively; Normalized collision energy , 20-40-60V rolling for MS/MS. Data acquisition was performed with the Data Dependent Acquisition (DDA) mode. The detection was carried out over a mass range of 70-1050 m/z.Diphenyl PhosphateIndole-3-Propionic Acid2-FluoroadenosineThr-PheDocosapentaenoic AcidL-Aspartyl-L-PhenylalanineUridine MonophosphateJanthitrem CSoyacerebroside I5-Hydroxy-2-Oxo-4-Ureido-2,5-Dihydro-1H Imidazole-5-CarboxylateEtorphineQuercetin-4'-GlucuronideGlutamyltyrosineSurfactin ATrimellitic AnhydrideOchratoxin BBz-Arg-OetN-Arachidonoyl GlutamineGlu-LeuBms-707035CarboxyifosfamideProlylprolinePhosphatidyl-D-SerinePe(32:1)Gpetn(16:0/16:1)Lithocholic Acid Glycine ConjugateAureothinPregnenolone SulfateTriphasiolOxidized DithiothreitolLipoxin A4Ethyl MyristateLeu-TyrPrednisonePetunidinScopoletinPorphobilinogenIndole-3-Carboxilic Acid-O-Sulphate3-Hydroxyanthranilic AcidAyapinGpetn(18:1/16:1)1-MethylxanthineIle-TyrN-Acetyl-L-MethionineEugeninGlucoconringiinEthotoin1-OleoylglycerophosphoserineEmideltideLevobunolol3-Methylthiopropyl-DesulfoglucosinolateGpetn(22:5/22:5)Eicosopentanoic AcidP-Coumaric Acid SulfateBolton-Hunter ReagentHomovanillic Acid SulfatePs(6 Keto-Pgf1Alpha/18:3(6Z,9Z,12Z))DeoxycholylisoleucineStarch AcetateCinncassiol A6-Keto-Prostaglandin F1ATridecanedioic AcidCinncassiol EIsopropylmaleic Acid(+/-)-TryptophanVal-IleDehydroeburicoic Acid3-Furoic AcidAmoxicilloylPhosphateOctadecenedioic AcidVeranisatin C2-Furoic AcidFlavin MononucleotideImidazolone AThiodi-Glycolic Acid2-LysophosphatidylcholineBisnoryangoninVal-PheBenzotriptPc(35:2)Succinyldisalicylic AcidCinncassiol C25-Deoxyribose-1-PhosphateFlavin Adenine DinucleotidePg(36:2)Piperonylic AcidDehydroisocoproporphyrinogenPhenylalanyl-Phenylalanyl-Arginine Chloromethyl KetoneN-Sulfo-D-GlucosamineCarboxy-Ethyl-HydroxychromanCyclo-Dopa 5-O-GlucosideArtonol BEtoricoxibPs(Dime(13,5)/Monome(13,5))1-Methyl-1,2-Dihydropyridine-3-CarboxamidePetasitenineAllylisopropylacetamidePipecuroniumAla-IleLeu-ValIsopentyl Beta-D-GlucosideGlutamylphenylalanineBetalamic AcidDodecanedioic AcidL-Proline, 1-Acetyl-4-Hydroxy-, Cis-Patuletin 7-GlucosideDg(Pgf2Alpha/I-22:0/0:0)OxandroloneNirvanol3-Methylxanthine8-OxoguanineN-(4-Aminobutyl)-N-EthylisoluminolCitric AcidPhe-GluPs(Dime(13,5)/Dime(11,5))5-Hydroxyferulic AcidLinalool (8-Hydroxydihydro-)Dg(Pgd2/A-15:0/0:0)Glucose Aspartate4,7-Dihydro-5-(4-Methyl-3-Pentenyl)-1,2,3-TrithiepinAerobactin5-MethoxytryptamineGlyceric AcidTrifluoroacetyl-L-Lysyl-L-AlaninanilideMycophenolic AcidGibberellin A53N-Acetylaspartic AcidCerebroside B3-Hydroxybenzoic Acid7-Methoxycoumarin-3-Carbonyl AzideCeranaprilElsibucolN-[2-(3,4-Dihydroxyphenyl)Ethyl]Icosa-5,8,11,14-TetraenamidePregn-4-Ene-3,20-Dione, 11,17,18,21-Tetrahydroxy-, (11Beta)-26-DeoxyacteinGlu-PheAbt-510Dg(Pgd2/I-19:0/0:0)Kynurenic AcidKanokoside Dnegletein 6-[Rhamnosyl-(1->2)-Fucoside]3'-Adenylic AcidGibberellin A24Thr-IleProstaglandin A1Myricetin 3-(6-Acetylgalactoside)Benzo(F)Quinolin-3(2H)-One, 8-Chloro-1,4,4A,5,6,10B-Hexahydro-4-Methyl-, Trans-DelprostenatoPhe-SerMelagatranIle-GluIsopropyl-Beta-D-ThiogalactopyranosideBendamustineObtusilactone A3-[4-Hydroxy-3-[3-(4-Hydroxyphenyl)Prop-2-Enoyloxy]Phenyl]Prop-2-Enoic AcidBetalone14,16-NonacosanedioneGamma-Glutamylisoleucine2-Hydroxynevirapine4-Nitrophenyl Beta-D-Glucopyranosiduronic Acid3-Nitrotyrosine2,3-Thioepoxy MadolN-Methyl-4,6,7-Trihydroxy-1,2,3,4-TetrahydroisoquinolineAlongside2-Hydroxy-4-Methylthiobutyric AcidMethyl 5-Hydroxyoxindole-3-AcetateTheogallinFosphenytoin4-Hydroxy-5-(3',4'-Dihydroxyphenyl)-Valeric Acid-O-GlucuronideBax Inhibitor Peptide V5PyrrolostatinSuberylglycineGlu-IleAtaluren2-Hydroxyestradiol2-Propylglutaric AcidGly-PheCycloheximide3'-N-Acetyl-4'-O-(10,12-Octadecadienoyl)FusarochromanoneIneketoneGlutaminyl-Gamma-GlutamateGpetn(16:1/18:1)Asp-Leu((4-(4-Amidinophenoxy)Butanoyl)Aspartyl)Valine3B,18B-3-Methoxy-11-Oxo-12-Oleanen-30-Oic AcidGanoderiol F4-Hydroxy-5-Phenyltetrahydro-1,3-Oxazin-2-OnePeimineSucroseCyclic Adp-RibosePgh1Leu-IleN-Phenylacetyl Pyroglutamic AcidGpetn(18:2/18:2)BardoxoloneTrans-2-Trans-4-Heptadien-1-OlIle-PhePolyanethole-SulfatePhosphonoacetatePe(40:5)MinocyclineDihydrodeoxy-8-EpiaustdiolClothianidinGlycine-BetaxanthinGibberellin A4Gibberellin A5(R)-1-O-[B-D-Apiofuranosyl-(1->2)-B-D-Glucopyranoside]-1,3-OctanediolCis-Aconitic Acid5-Methylthioribose2,3,4,5-Tetrachloro-4'-BiphenylolPe(14:0/0:0)5-(3',5'-Dihydroxyphenyl)-Gamma-Valerolactone SulfateS-GlutaryldihydrolipoamideBucladesineOseltamivir8-HydroxycarvedilolCholylhistidine4-O-(Indole-3-Acetyl)-D-GlucopyranoseGlycyl-L-LeucineNelumbosideGinkgolic Acid11-Beta-Hydroxyandrosterone-3-Glucuronide5-Chloro-2'-DeoxyuridineAflatoxin P1AdrenoylcarnitinePhthalateDehydrocyanaropicrin7,8-Dehydro-Beta-Micropteroxanthin1,4-Dihydroxy-2-Naphthoic AcidDiflucortoloneBeta-D-Glucopyranuronic AcidP-Toluenesulfonic AcidD-Dopachrome(S)-2,3-DihydrodipicolinateLeu-Met4-NitrophenolThr-LeuAspartylglycosamineApigeninN-(1-Deoxy-1-Fructosyl)ValineXanthosine 5'-MonophosphateLuteolin4-Nitroquinoline-1-OxideTetradecanedioic AcidN-Acetyl-9-Aminominocycline, (4R)-NoreugeninPhyllanthusol BPe(34:3)(S,E)-2-(5-Hydroxy-8,9-Dihydro-5H-Benzo[7]Annulen-6(7H)-Ylidene)Acetic AcidCappariloside AUrea CitrateGlycyrrhetinic AcidAsp-IleIbritumomab Tiuxetan1,3,5-Trichloro-2-MethoxybenzeneDesmethyl Bosentan1,4-Dihydro-2-MethylbenzoicacidPurpurogallinAbietinalGlu-ValAbscisic AcidXanthineSulfobutyl EtherLaurenoniolideN-Acetylneuraminic AcidCordycepinFraxinSagecoumarinPc(33:0)VaccarinS-(2-Hydroxyethyl)GlutathioneIndicine-N-Oxide8H-1,3-Dioxolo[4,5-H][1]Benzopyran-8-OneSobetiromeBilobalide A3'-N-Acetyl-4'-O-(14-Methylpentadecanoyl)Fusarochromanone1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine5-(4'-Hydroxyphenyl)-Gamma-Valerolactone 4'-SulfateSinapic Acid SulfatePe(36:2)Leu-GluDialdehyde10-Octacosene-1,12-DiolGpetn(18:1/18:1)Lpc(18:3)3,4-Dihydroxyphenylpyruvate2-Hydroxy-6-[(8Z,11Z)-Pentadeca-8,11-Dienyl]Benzoic AcidGamma-GlutamylmethionineDimercaptosuccinic Acid Monomethyl EsterTriethylene Glycol Bis(3-Tert-Butyl-4-Hydroxy-5-Methylphenyl)PropionateGibberellin A8-Catabolite5-(3',5'-Dihydroxyphenyl)-Gamma-Valerolactone-O-Sulphate-O-Methyl11-Deacetylvaltrate 11-(3-Hydroxy-3-Methylbutanoate)10-Hydroxydecanoic AcidCefpiromePiscidic AcidPg(34:1)Pe(P-16:0/18:2)7,8-Dichloro-1,2,3,4-TetrahydroisoquinolinePhenylalanylaspartic Acid(Imidazolylbiphenylyl)SulfonylureaIndole-3-Acetyl-Tryptophan3-(2-Propenoic Acid)-O-BenzoquinoneVulgarinCoriandrone E2,4-DihydroxybenzophenoneFasoracetamSer-LeuAtorvastatinN(Alpha)-PhosphorylalanylprolineTrans-3,5-Diethyl-1,2,4,-TrithiolaneEthyl CelluloseDaphnoretinPa(5-Iso Pgf2Vi/19:2(10Z,13Z))Gemcitabine5-Cholesten-3Beta-25-Diol-3-Sulfate17A,21-Dihydroxy-5B-Pregnane-3,11,20-TrioneTrans-P-Menthane-7,8-Diol 7-Glucoside3',6'-Dihydroxy-4,5-Diaminospiro[Isobenzofuran-1(3H),9'-[9H]Xanthene]-3-One2-Methylcitric AcidRaffinoseDocosanalCoumachlorToluidineAlectrolLeu-Ser17Z-Hexacosenoic AcidDecane-1-Sulfonic Acid2,5-Furandicarboxylic AcidGlycyrrhizaisoflavone BTryptophyl-SerineIsopropyl Beta-D-Glucoside5,7-Dihydroxy-4H-1-Benzopyran-4-OneIndophenolProstaglandin J2Traumatic AcidKuguacin BN-Acetyl-Dl-PenicillamineVicenin 2Dynorphin A (6-8)IndenololChondroitin4-P-Coumaroylquinic AcidHemateinFrangulosideIsolinderenolidePe(40:6)GlycylphenylalanylleucylglycineN-Feruloylaspartic Acid3-Keto-B-D-GalactoseHenatinibGemopatrilatfalseIntercropping with Peucedanum praeruptorum enhances the growth and quality of Pseudostellaria heterophyllaPseudostellaria heterophylla, a valued shade-loving traditional Chinese medicinal herb, faces severe yield and quality decline under continuous monocropping, threatening industry sustainability. Intercropping, which leverages niche complementarity, offers an eco-friendly mitigation strategy, but its regulatory mechanisms on P. heterophylla remain unclear. Here, we evaluated the influence on P. heterophylla intercropped with Peucedanum praeruptorum via field/hydroponic experiments, integrating phenotypic, photosynthetic, metabolomic, and transcriptomic analyses. Intercropping significantly promoted P. heterophylla growth and yield in a density-dependent manner. High-density intercropping (IS3) increased the fresh weight of plant by 202.80%,and increased the yield of tuberous root by 82.67% compared to monoculture (MPh). Despite reduced photosynthetic rate, intercropping sustained chlorophyll content and reduced damping rate by up to 58.33%, prolonging the effective photosynthetic period to compensate for light limitation. Medicinal quality was concurrently improved. Heterophyllin B, the core bioactive component, rose from 0.0064% (MPh) to 0.0099% (IS1), 0.0093% (IS2), and 0.0096% (IS3), with total saponins and crude polysaccharides also elevated slightly. Additionally, metabolomic analysis identified 1157 differentially accumulated metabolites (DAMs). Peptides, terpenoids, and intermediate products of polysaccharide biosynthesis were enriched under intercropping treatment, promoting quality metabolites biosynthesis. Transcriptomic profiling revealed 141 shared differentially expressed genes (DEGs) across intercropping treatments, with upregulation of light-harvesting complex (LHCA4/LHCB1), chlorophyll metabolism (chlE/chlH), and bioactive component synthesis (PREP/CTSF/SQLE) genes. Weighted gene co-expression network analysis (WGCNA) identified the MEred module correlated with biomass and key transcription factors (GRAS,GATA,BHLH1) regulating growth and metabolites biosynthesis. Collectively,P. praeruptorum intercropping creates a favorable microenvironment, triggering adaptive photosynthetic reprogramming and activating hormone-signaling, secondary metabolism, and nutrient transport pathways to synergistically improve P. heterophylla growth, yield, and quality. This study reveals the adaptive mechanism of shade-tolerant medicinal plants to the environment under intercropping conditions, and has provided theoretical and practical guidance for the ecological cultivation of P. heterophylla.2026-05-062026-03-21MTBLS14102HMDB0028893HMDB0000148;PW_C000095HMDB0002113HMDB0038625HMDB0012267HMDB0037759HMDB0257954HMDB0060617HMDB0000001HMDB0000283HMDB0001185HMDB0000034;PW_C000024HMDB0248497HMDB0000132HMDB0259142HMDB0014634HMDB0255658HMDB0028684HMDB0253490HMDB0060410HMDB0256878HMDB0248452HMDB0028886HMDB0258379HMDB0041379HMDB0003950HMDB0250970HMDB0255983HMDB0028839HMDB0000050;HMDB0247583;PW_C000034HMDB0253048HMDB0001991;PW_C001335HMDB0258970HMDB0000089HMDB0036583;LMFA02020010HMDB0041419HMDB0303767HMDB0002017HMDB0028691HMDB0015132HMDB0013062HMDB0035372HMDB0015122HMDB0243530HMDB0256045HMDB0033691HMDB0011741HMDB0253109HMDB0000210;HMDB0250782;PW_C000136HMDB0246838HMDB0254740HMDB0241109HMDB0000671HMDB0034777HMDB0061822HMDB0015441HMDB0240458HMDB0002089HMDB0060442HMDB0302755HMDB0001938HMDB0001901HMDB0029737HMDB0000037HMDB0005796HMDB0246756HMDB0037592HMDB0304788HMDB0258292HMDB0246429HMDB0000594HMDB0014825HMDB0004081HMDB0254838HMDB0255464HMDB0032764HMDB0256780HMDB0002706HMDB0250877HMDB0002390HMDB0062645HMDB0036157HMDB0304408HMDB0029448HMDB0257599HMDB0041920HMDB0015321HMDB0250616HMDB0258230HMDB0060852;PW_C040611HMDB0250954HMDB0251157HMDB0003556HMDB0036434HMDB0252432HMDB0245544HMDB0015095HMDB0032012HMDB0030641HMDB0037582HMDB0033965HMDB0014322HMDB0255226HMDB0252833HMDB0028981HMDB0240687HMDB0248298HMDB0038995HMDB0015485HMDB0249137HMDB0036317HMDB0247867HMDB0258290HMDB0032997HMDB0251007HMDB0247595HMDB0005771HMDB0257938HMDB0303942HMDB0302720;HMDB0034277HMDB0258812HMDB0014514;PW_C008891HMDB0038516HMDB0060826HMDB0248001HMDB0004708HMDB0036648;LMPR0103410006HMDB0035612HMDB0006294HMDB0005020HMDB0301837HMDB0059764HMDB0258876HMDB0257249HMDB0000086HMDB0254704HMDB0060850HMDB0015043;HMDB0243537;PW_C009355HMDB0252101HMDB0258235HMDB0257571HMDB0014376HMDB0253475HMDB0250941HMDB0257277HMDB0031763HMDB0036456HMDB0304223HMDB0251890HMDB0003072HMDB0001932HMDB0034146HMDB0242408HMDB0015281HMDB0038122HMDB0301821HMDB0012220HMDB0036453HMDB0031936HMDB0033135HMDB0015002HMDB0030466HMDB0252324HMDB0037559HMDB0015193HMDB0302864HMDB0038202HMDB0033243HMDB0033960HMDB0036423HMDB0248818HMDB0248395HMDB0248559HMDB0040615HMDB0035934HMDB0036685HMDB0035915;LMFA12000039HMDB0012283HMDB0039522HMDB0034714HMDB0258762HMDB0034889HMDB0002825HMDB0010697HMDB0036789HMDB0113986HMDB0036791HMDB0010388HMDB0009702HMDB0256501HMDB0033244HMDB0263298HMDB0060928HMDB0007735HMDB0252258HMDB0299873HMDB0299848HMDB0303486HMDB0010403HMDB0056287HMDB0036289HMDB0060285;HMDB0245270HMDB0007984HMDB0290230HMDB0032802HMDB0008928HMDB0242528HMDB0008003HMDB0248571HMDB0034770HMDB0039225HMDB0257062HMDB0007958HMDB0008843HMDB0041365HMDB0014559HMDB0007904HMDB0014756HMDB0030898HMDB0116711HMDB0008957HMDB0299877HMDB0011773HMDB0005772HMDB0250247HMDB0008376HMDB0249243HMDB0000593HMDB0039020HMDB0038496HMDB0003759HMDB0252404HMDB0036804HMDB0010734HMDB0038521HMDB0034840HMDB0256579HMDB0032090HMDB0094660HMDB0002107HMDB0280928HMDB0038787HMDB0276267HMDB0276689HMDB0034671HMDB0254292HMDB0295721HMDB0240685HMDB0257480HMDB0289934HMDB0251255HMDB0008844HMDB0256940HMDB0256601HMDB0002285HMDB0004186HMDB0014692HMDB0245090HMDB0033895HMDB0036769HMDB0251893HMDB0252704HMDB0246435HMDB0302259HMDB0260432HMDB0250266HMDB0260833HMDB0242599HMDB0036298HMDB0041036HMDB0248600HMDB0002982HMDB0059904HMDB0035407HMDB0303570HMDB0033679HMDB0255642HMDB0254413HMDB0031042HMDB0060745HMDB0254917HMDB0060121HMDB0037340;LMPK12110336HMDB0257897HMDB0303366HMDB0035240HMDB0033884HMDB0302593HMDB0029770HMDB0006472HMDB0062374HMDB0038361;HMDB0302404;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;PW_C000741HMDB0001173HMDB0244684HMDB0244264HMDB0032959HMDB0255167HMDB0001180HMDB0011175HMDB0250542HMDB0002224HMDB0248160HMDB0249836HMDB0001904;HMDB0255667HMDB0014716HMDB0000101;PW_C000068HMDB0041102HMDB0248104HMDB0029838HMDB0245300HMDB0000904HMDB0034719HMDB0041887HMDB0042008HMDB0004662HMDB0012275HMDB0303713HMDB0001972HMDB0001889HMDB0253185HMDB0002641HMDB0015129HMDB0028761HMDB0001406;HMDB0303717HMDB0000786;HMDB0002818;HMDB0000786HMDB0028954HMDB0254874HMDB0251551HMDB0247051HMDB0000045;PW_C00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