MetaboLights

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identification was performed by matching accurate mass, retention time, and MS/MS fragmentation patterns against public and in-house databases. Reference databases included HMDB (Human Metabolome Database), METLIN, MassBank, and KEGG. Putative identifications were assigned based on mass accuracy and spectral similarity. When available, MS/MS spectra were compared with reference spectra to improve confidence in annotation. Metabolites were annotated according to commonly accepted levels of confidence (e.g., MSI guidelines), with most features assigned as putatively annotated compounds.MetaboLightsPublicLiquid Chromatography MS - positive - hilicLiquid Chromatography MS - negative - hilicChromatographic separation was performed using a UHPLC system equipped with a C18 column. Mobile phases consisted of water and acetonitrile with 0.1% formic acid. Gradient elution was applied, with a flow rate of 0.3 mL/min and an injection volume of 2–5 μL. The column temperature was maintained at 40°C, and samples were kept at 4°C prior to analysis.Metabolomic profiling of goat testicular tissue under combined uranium and cesium exposure.Duo KeaiPeking UniversityTestismass spectrometry assayMetabolites were extracted from testicular tissue using a cold organic solvent-based protocol. Samples were homogenized, centrifuged, and supernatants collected for analysis. Extracts were dried and reconstituted prior to LC–MS analysis. Pooled quality control (QC) samples, solvent blanks, and internal standards (if applicable) were included to ensure data quality and reproducibility.Capra hircushttps://www.ebi.ac.uk/metabolights/MTBLS14119Xiaoyun Shen. Southwest University of Science and Technology. shenxy@swust.edu.cn.Xinghong Zhou. Southwest University of Science and Technology. zhouxinhong97@163.com.Raw LC–MS data were converted into an open format (e.g., mzXML/mzML) using vendor-specific software or MSConvert (ProteoWizard). Data processing, including peak detection, retention time alignment, and peak integration, was performed using appropriate software (e.g., XCMS, MZmine, or Compound Discoverer). The resulting feature table was subjected to data filtering to remove low-quality features (e.g., features with high missing rates or low signal intensity). Signal drift and batch effects were corrected using quality control (QC)-based normalization methods where applicable. Data were further normalized (e.g., total ion current normalization or internal standard normalization) and scaled prior to downstream statistical analysis.Groupkeaiduoduo998@126.comTesticular tissue and blood samples were collected from goats under controlled experimental conditions. Samples were obtained at defined time points and processed immediately after collection. Blood samples were centrifuged to obtain serum. Testicular tissues were dissected and divided for multiple analyses. Portions were snap-frozen in liquid nitrogen and stored at 80°C, while others were fixed for morphological assessment. Sample collection and storage procedures were standardized to maintain sample integrity.Metabolomicsreproductive biologymetabolomicsenvironmental exposuregoattestisreproductive biologymetabolomicsenvironmental exposuregoattestisMass spectrometry was performed using a high-resolution instrument with an electrospray ionization (ESI) source in both positive and negative modes. Data were acquired over an m/z range of 70–1000. Key parameters, including capillary temperature, spray voltage, and gas flow, were optimized for stable analysis. MS/MS data were collected for metabolite identification.FAPy-adeninePalmitic amideN-AcetylserotoninCreatineIsobutyrylcarnitineSuccinyladenosineBetaineOxiglutatione2-AcetylpyrazineCytosine4-AminophenolTyramine3-Hydroxy-2-methyl-4H-pyran-4-oneTrigonellineo-TyrosinePhthalic acidThreonineAlanylphenylalanineMethionineCinnamoylglycineLenticinGlycyl-L-leucineCytidineCarnitinePhenol2'-Adenylic acidLysine2-(((R)-2,3-Dihydroxypropyl)phosphoryloxy)-N,N,N-trimethylethanaminiumHypoxanthine3'-Adenylic acidO-acetyl-L-serineOrnithineLPC(18:0_0:0)Cys-GlyPhe-PheIndoleAdenylosuccinic acidPhenylalanyltyrosineTyrosyltyrosineGlycineS-adenosylmethionine2-PhenoxyethanolL-NorleucineEpsilon-caprolactamp-Aminobenzoic acid1-PhenylethanolPiperidinePyrrolidinePyridoxamine2-Amino-1-phenylethanolCreatinineNiacinamideTryptophanAdenineAcetyl-L-carnitineGlu-IlePhosphocreatineXanthine7-MethylguanineAdenosine-5'-diphosphateCholineUracilLumichrome5-MethoxytryptopholgammGlutamylglutamineGlutaminefalseMetabolomic profiling of goat testicular tissue under graded uranium exposureThis study presents metabolomic profiles of goat testicular tissue obtained under controlled exposure conditions. An untargeted metabolomics approach was applied to characterize global metabolic alterations associated with environmental contaminants. The dataset provides information on small-molecule metabolites and supports investigations into metabolic responses in reproductive tissues under stress conditions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