The resulting data matrix was further processed on the Majorbio cloud platform. Metabolic features detected in at least 80% of samples in any group were retained. Missing values were imputed using the minimum observed value, and signal intensities were normalized to the sum. Variables with relative standard deviation (RSD) > 30% in QC samples were excluded, and the retained data were log10-transformed before downstream analyses. Principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) were performed using the R package ropls, and differential metabolites were screened using VIP > 1 and p < 0.05. Pathway enrichment analysis of differential metabolites was performed based on the KEGG database. Metabolite annotations generated in this workflow were derived from untargeted database matching and should be interpreted as putative metabolite identifications rather than targeted quantitative confirmation.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - negative - reverse-phase","Liquid Chromatography MS - positive - reverse-phase"],"chromatography_protocol":["LC separation was performed on a UHPLC-Q Exactive HF-X system equipped with an ACQUITY HSS T3 column (100 mm × 2.1 mm i.d., 1.8 μm; Waters, USA) at Majorbio Bio-Pharm Technology Co., Ltd. (Shanghai, China). The column temperature was maintained at 40 °C, the flow rate was 0.40 mL/min, and the injection volume was 5 μL. The mobile phase consisted of solvent A, 0.1% formic acid in water:acetonitrile (2:98, v/v), and solvent B, 0.1% formic acid in acetonitrile. A suitable gradient elution program was applied according to the instrument method for untargeted metabolomics analysis.
"],"publication":["Aqueous Artemisia argyi extract mitigates acute lung injury in association with coordinated alterations in gut microbiota, metabolic homeostasis, and pulmonary inflammatory gene expression."],"submitter_affiliation":["Tarim university"],"submitter_name":["æµ·å® ç¦"],"organism_part":["Serum"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["Serum samples were processed as liquid samples for metabolite extraction. Briefly, 100 μL of serum was transferred to a 1.5 mL centrifuge tube and mixed with 800 μL extraction solvent (acetonitrile:methanol = 1:1, v/v) containing internal standards. Samples were vortexed for 30 s and subjected to low-temperature ultrasonic extraction for 30 min at 5 °C and 40 kHz to facilitate protein precipitation and metabolite extraction. The mixture was then incubated at -20 °C for 30 min and centrifuged at 13,000 g for 15 min at 4 °C. The supernatant was collected and evaporated to dryness under nitrogen, reconstituted in 100 μL acetonitrile:water (1:1, v/v), sonicated for 5 min at 5 °C, and centrifuged again at 13,000 g for 10 min at 4 °C. The final supernatant was transferred to LC-MS vials for instrumental analysis. Quality control (QC) samples were prepared by pooling equal aliquots from all serum extracts and were injected at regular intervals during the analytical sequence to monitor system stability and analytical reproducibility.
"],"organism":["Mus musculus"],"data_transformation_protocol":["Raw LC-MS data were imported into Progenesis QI (Waters Corporation, Milford, USA) for baseline correction, peak picking, peak integration, retention time alignment, and generation of a three-dimensional data matrix containing retention time, mass-to-charge ratio, and ion intensity information. Metabolite annotation was performed by matching MS and MS/MS spectra against public databases including HMDB and METLIN, together with an in-house spectral database. Internal standard peaks and known false-positive signals, including background noise and column bleed, were removed before statistical analysis.
"],"study_factor":["Treatment"],"metabolights_link":["https://www.ebi.ac.uk/metabolights/MTBLS14160"],"submitter_email":["jhhdky@126.com"],"sample_collection_protocol":["Male C57BL/6 mice were acclimatized for 7 days and then randomly assigned to five groups: control, LPS, low-dose AEAA, mid-dose AEAA, and high-dose AEAA. AEAA was administered via drinking water for 28 consecutive days. On day 29, acute lung injury was induced in the LPS and AEAA-treated groups by intratracheal instillation of lipopolysaccharide (LPS, 5 mg/kg), while control mice received an equivalent volume of sterile saline. Eight hours after LPS administration, mice were euthanized by intraperitoneal overdose of sodium pentobarbital (150 mg/kg), followed by cervical dislocation to ensure death. Blood was collected aseptically immediately after euthanasia, allowed to clot, and centrifuged to obtain serum. Serum samples were aliquoted, snap-frozen in liquid nitrogen, and stored at -80 °C until LC-MS metabolomics analysis. Representative serum samples from each experimental group were selected for untargeted metabolomic profiling.
"],"omics_type":["Metabolomics"],"study_design":["Design","treatment","Metabolomics","Mus musculus","metabolite profiling assay","quality control","Thermo Scientific Vanquish Flex UHPLC System","Thermo Scientific Q Exactive HF-X","Serum","untargeted metabolite profiling"],"curator_keywords":["Design","treatment","Metabolomics","Mus musculus","metabolite profiling assay","quality control","Thermo Scientific Vanquish Flex UHPLC System","Thermo Scientific Q Exactive HF-X","Serum","untargeted metabolite profiling"],"mass_spectrometry_protocol":["Mass spectrometric detection was carried out using a Q Exactive HF-X mass spectrometer equipped with an electrospray ionization (ESI) source operated in both positive and negative ion modes. The source temperature was set at 425 °C, sheath gas flow at 50 arb, and auxiliary gas flow at 13 arb. The ion-spray voltage floating was set to -3500 V in negative mode and 3500 V in positive mode. MS/MS acquisition was performed using data-dependent acquisition (DDA), with normalized collision energies of 20-40-60 V. Data were acquired over an m/z range of 70-1050.
"],"metabolite_name":["Saikosaponin A","Corticosterone","Lpc(O-18:0)","Cephaloglycin","Serylthreonine","3-Indole Carboxylic Acid Glucuronide","Lumirubin","N,N-Dimethyltetradecylamine-N-Oxide","Thiencynonate","L-Histidine","N-(3-Methyl-2-Pyridyl)-3-Phenylsuccinimide","Pc(20:0/0:0)","Gln-Gly-Thr","Pi(38:4)","1,5-Naphthalenediamine","7,8-Dihydroxy-3,5,7-Trimethyl-8,8A-Dihydro-1H-Isochromen-6-One","15-Acetoxyscirpene-3,4-Diol 4-O-A-D-Glucopyranoside","Selanc","Gpcho(20:5/20:4)","2-Hydroxy-6-Pentadeca-8,11,14-Trienylbenzoic Acid","Cimiracemoside D","(+/-)-(Z)-2-(5-Tetradecenyl)Cyclobutanone","Delta-Valerobetaine","Docosa-4,7,10,13,16-Pentaenoyl Carnitine","15-Cyclohexyl Pentanor Pgf2Alpha","4-Hydroxybenzaldehyde","6,7-Diketolithocholic Acid","Gant61","Prostaglandin E1","Sm(8:0_2O/24:1)","Methyl Isoquinoline-3-Carboxylate","S-(Pgj2)-Glutathione","Dg(Lte4/I-20:0/0:0)","4-(Hydroxymethyl)-3-(1-Hydroxy-7-Methyloctyl)Oxolan-2-One","Gpcho(20:4/17:0)","Gpcho(20:5/20:5)","1-[4-(4-Chlorophenyl)Piperazin-1-Yl]-N-Propan-2-Ylisoquinoline-7-Carboxamide","Glutamylisoleucine","(D-Pen2,D-Pen5)-Enkephalin","5,8,11-Eicosatriynoic Acid","Gamma-Glutamyltyrosine","N-Cyclohexanecarbonylpentadecylamine","Butaprost","Maltopentaose","(Z)-2-Oct-7-Enylpent-2-Enedioic Acid","N-Bisdesmethyl Tramadol","23S,25,26-Trihydroxyvitamin D3","4-Methylstyrene","Isophorone","Oleamide","Cinnamic Acid","N-(2-Aminobenzoyl)Alanine","4-Pentenoic Acid","6-Methylthioguanosine Monophosphate","N-[(3,4,5-Trimethoxyphenyl)Methyl]-2-(3,3,5-Trimethyl-2-Oxoindol-1-Yl)Acetamide","Ser Ile Ala Asp","Salicylaldehyde","(Z)-9-Cycloheptadecen-1-One","Prostaglandin C1","3,5-Di-Tert-Butyl-4-Hydroxybenzyl Alcohol","7-Deoxyechinosporin","L-Ornithine","Dihydro-Alpha-Ionone","Gpcho(18:2/16:1)","N-Acetyllactosamine","Dimethisterone","Kanamycin","Lpc(17:2-Sn1)","Cryptoxanthin Epoxide","Asp His Phe Asp","3-Hydroxymyristic Acid","N-(2-Hydroxy-3-Methoxy-2-Methylpropyl)-2-(3-Methylphenyl)Acetamide","Choldienic Acid","Lpc(20:3-Sn1)","1-Oleoyl-2-Palmitoyl-Sn-Glycero-3-Phosphocholine","7-O-Methylbavachin","Retinal","Gpcho(18:4/2:0)","(24R)-24,25-Dihydroxyvitamin D2/(24R)-24,25-Dihydroxyergocalciferol","Torvoside D","Isovalerylcarnitine","Indole","N-(Thiadiazole-4-Carbonyl)Morpholine-4-Carboxamide","(2-Oxo-2,3-Dihydro-1H-Indol-3-Yl)Acetic Acid","Prostaglandin A1","Muzanzagenin","Glutamylasparagine","Ritipenem","Pg(Pge2/I-17:0)","21-Desacetyl Deflazacort","Andromedol","Gamma-Glutamylisoleucine","Leupeptin","Butyraldehyde","1-[4-([1,3]Oxazolo[5,4-B]Pyridin-2-Yl)-1,4-Diazepan-1-Yl]-2-Phenylpropan-1-One","Pelargonidin 3-(6''-Malonylglucoside)","Tyr-Val-Oh","2-Amino-3,4-Dimethylimidazo[4,5-F]Quinoline","3-(3-Chlorophenyl)-N-(2-Methoxyethyl)-6-Methyl-1,2,4-Triazin-5-Amine","L-Thyroxine","Val-Pro-Arg","Dilinoleoylphosphatidylcholine","Bz-Ile-Glu-Gly-Arg-Pna","Cathinone","Menthofuran","Oleoyl-L-Carnitine","Lpc(22:4-Sn1)","(2R,3R,4R,5R)-2-Amino-4,5,6-Trihydroxy-3-[(2R)-1-Oxopropan-2-Yl]Oxyhexanal","L-Phenylalanine","Soyasaponin Gamma-G","Pc(Pgj2/P-16:0)","5-Amino-2-(1,3-Dioxooctahydro-2H-4,7-Methanoisoindol-2-Yl)-5-Oxopentanoic Acid","Myristoyllysophosphatidylcholine","Lauramine Oxide","Dg(Lte4/A-17:0/0:0)","3-[1-(Benzenesulfonyl)Piperidin-4-Yl]-N-Cyclopentylpropanamide","Pe(O-15:0/3:0)","(9E)-Dodecenoylcarnitine","Sphingosine","15-Keto-Prostaglandin F2A","7-Hydroxy-6-Methoxydihydroflavonol","Gpcho(22:6/18:2)","Phe Ala Ser Thr Val","Natamycin","Deltonin","Libenzapril","Lomatin","Dithianon","16-Hydroxyhexadecanoylcarnitine","Dg(Pgf1Alpha/8:0/0:0)","Gamma-D-Glutamylglycine","Salvianolic Acid A","Trans-3-Indoleacrylic Acid","Jasmonic Acid","N-(4-(2,5-Dihydro-5-Oxo-3-Furanyl)Phenyl)-4-(Beta-D-Glucopyranosyloxy)Benzamide","Octadecylamine","(-)-Isolonchocarpin","Glu-Lys-Ile","4(5)-Epdpe Methyl Ester","Cystine-Glutamate","Indole-3-Carboxaldehyde","Pe(O-9:0/10:0)","6Beta-Hydroxycortisol","(9R,10E,12Z,15Z)-9-Hydroxyoctadeca-10,12,15-Trienoic Acid","(R)-Glabridin","Nigericin","5Alpha-Androstan-3,6,17-Trione","3,6,9,12,15,18,21,24,27,30-Decaoxadotriacontane-1,32-Diol","Pc(5-Iso Pgf2Vi/18:1(11Z))","L-Hexahydro-3-Imino-1,2,4-Oxadiazepine-3-Carboxylic Acid","Ampk Inhibitor, Compound C","Ser Leu Trp","(3Z)-Phytochromobilin","Gpcho(18:3/2:0)","Arachidoyl Ethanolamide","17-(Acetyloxy)-3-Hydroxy-6-Methyl-(3B,5B,6A)-Pregnan-20-One","Alpha-Irone","2'-Deoxyuridine","Pc(P-18:0/2:0)","1,25-Dihydroxy-16-Ene-23-Yne-Vitamin D3","Stachyose","1,4-Ipomeadiol","3,5-Ditert-Butyl-4-Hydroxybenzaldehyde","Dg(O-20:5/16:0)","Pc(17:0/0:0)","1-Palmitoyl-Sn-Glycero-3-Phosphocholine","9-Carboxymethoxymethylguanine","2-(2,5-Difluorophenyl)-5-(6-Imidazol-1-Ylpyridin-3-Yl)-1,3,4-Oxadiazole","Pi(17:0/20:3)-D5","Floionolic Acid","{4-Methyl-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazol-5-Yl}Methanol","8A-Hydroxy-3,3,6,6,8,8-Hexamethyl-1,2-Benzodioxine-5,7-Dione","Fa(18:2+3O)","Milbemycin Beta3","N-Desmethyl-Loperamide","Gly-Thr","Cafestol","Genistein","Dg(Lte4/I-22:0/0:0)","3-[(3-Fluorophenyl)Methylsulfanyl]-6-Imidazol-1-Ylpyridazine","3-Ketosphingosine","O-Adipoylcarnitine","Cys-Arg-Glu-Lys-Ala","Trp-Gln-Lys","Lpc(24:0)","Sesamolinol 4'-O-B-D-Glucosyl (1->6)-O-B-D-Glucoside","1-Methyladenosine","N-Stearoyl Valine","1-(4-Ethoxy-3-Methylphenyl)Sulfonyl-N-(2-Methoxyethyl)Piperidine-3-Carboxamide","Pc(18:0/22:5)","Tamsulosin","Apc","Dodecanoic Acid","1-Methylhistamine","Epothilone A","Epothilone C","Zalcitabine","(23S,24S)-17,23-Epoxy-24,29-Dihydroxy-27-Norlanost-8-Ene-3,15-Dione","Gpcho(18:4/18:2)","Lpc(22:6-Sn1)","Pc(20:2/0:0)","Geldanamycin","Tetraethylene Glycol","Longicamphenylone","Dibutyl Sebacate","Piperonyl Butoxide","(2'E,4'Z,7'Z,8E)-Colnelenic Acid","Sphingosine 1-Phosphate","Benzenebutanoic Acid, Alpha-(Acetylamino)-2-Amino-Gamma-Oxo-","N-(3-Chlorophenyl)-2-Phenylimidazo[1,2-A]Pyrazin-3-Amine","Gpcho(18:4/18:3)","Lycoctonine","Glu Tyr Asp Lys","Phytuberin","Cholesterol Sulfate","Gpcho(20:4/20:5)","1-Oleoyl-2-Myristoyl-Sn-Glycero-3-Phosphocholine","Chloramphenicol Palmitate","Perilloside C","24,25-Hydroxyvitamin D3","Dg(9M5/11M3/0:0)","Momorcharaside A","1-Methylguanosine","8,8A-Diepiswainsonine","Docosapentaenoic Acid (22N-3)","Indoxyl Glucuronide","Arachidonoylcarnitine","Blumenol C Glucoside","Dehydroeburicoic Acid","(8Z,11Z,14Z,17Z)-Icosa-8,11,14,17-Tetraenoylcarnitine","Octopamine","2-Acetamido-5-Oxo-5-(2-Phenylethylamino)Pentanoic Acid","Suloctidil","L-Tryptophan","Triethanolamine","Zacopride","Trans-Zeatin-D5","Levocarnitine","Pro-Phe-Arg-Mca","Phe His Arg","Pa(Pgd2/I-22:0)","1-Octen-3-Yl Primeveroside","N-[[5-(2-Methylpropyl)-1,2,4-Oxadiazol-3-Yl]Methyl]Cyclohexanecarboxamide","L-Valine","Ps(Pgf2Alpha/18:4(6Z,9Z,12Z,15Z))","Cuminaldehyde","3-Indolepropionic Acid","Nor-9-Carboxy-Delta9-Thc","N-[[1-(Hydroxymethyl)Cyclopropyl]Methyl]-2,1,3-Benzothiadiazole-5-Carboxamide","N-[6-(3-Cyclopentyl-2-Oxoimidazolidin-1-Yl)Pyridin-3-Yl]-3-Fluorobenzamide","Dinophysistoxin 1","Ropivacaine","1-Methylbenzotriazole","(1'R)-Nepetalic Acid","Creatine","5-Hydroxyindole-3-Acetic Acid","Tris(1-Chloro-2-Propyl) Phosphate","Ophthalmic Acid","1-Palmitoyl-2-Myristoyl-Sn-Glycero-3-Phosphocholine","D-Linalool 3-Glucoside","Gpcho(3:0/17:2)","1-(4-(5-Maleimidopentyl)Aminobenzyl)Ethylenediaminetetraacetic Acid","Pe(20:5/0:0)","2-Dec-9-Enylpentanedioic Acid","Cervonoyl Ethanolamide","13-Nor-6-Eremophilene-8,11-Dione","Cytosine","1H-Indene-3-Carboxamide","Pe(16:3/24:6)","Laurocapram","1-(4-Butylphenyl)-4-(3,4-Dimethoxyphenyl)Piperidine-2,6-Dione","Degalloyl Theasinensin F","N6-Methyladenosine","Pc(O-14:0)","Decaethylene Glycol","Val-Gly-Val-Ala-Pro-Gly","Lucidenic Acid G","Gpcho(17:2/15:1)","2,4,5-Trimethoxystyrene","(+-)-Zoapatanol","Brassinolide","5,7-Megastigmadien-9-Ol Glucoside","[4-(2-Ethoxyethoxy)Piperidin-1-Yl]-(Furan-3-Yl)Methanone","12-Methyltridecanoic Acid","Pc(16:1/0:0)","Gamma-Glutamylphenylalanine","Xanthotoxol Arabinoside","3-Benzyl-6-(1H-Indol-3-Ylmethyl)Piperazine-2,5-Dione","Kynurenic Acid","Kobusone","Strophanthin","Alpha-Linolenic Acid","Riesling Acetal","Asp-Gly-Asp","Vernolic Acid","Octaethylene Glycol","4-Benzyl-2-[2-(Cyclohexen-1-Yl)Ethylamino]Pyrido[3,4-B]Pyrazin-3-One","(S)-Alpha-Terpinyl Glucoside","Choline Phosphate","1-[2-(2-Oxoimidazolidin-1-Yl)Ethyl]-3-[4-(Trifluoromethoxy)Phenyl]Urea","Alpha-Bixin","Lovastatin Acid","Pe(P-18:0/0:0)","Salannin","Indole-3-Lactic Acid","Deoxycarnitine","2-Aminopropanol","N,N-Dimethylglycine","Canrenone","Agar","2,5-Dimethyl-N-[(2-Methyl-2-Azaspiro[4.5]Decan-4-Yl)Methyl]Benzenesulfonamide","(10Z,12E)-Hexadecadienoylcarnitine","(10Z,12E)-Tetradecadienoylcarnitine","N-[2-(2-Chlorophenyl)Ethyl]-1-(4-Methylpyrimidin-2-Yl)Piperidine-3-Carboxamide","Gpcho(2:0/20:5)","N-Palmitoyl Cysteine","4-Hydroxyindole","L-(+)-Citrulline","(1-Ethylpyrazol-3-Yl)-[4-[(3-Propoxypyrazin-2-Yl)Amino]Piperidin-1-Yl]Methanone","Eupomatenoid-4","3'-Carbamoyl-[1,1'-Biphenyl]-3-Yl Cyclohexylcarbamate","1-Nonadecanoyl-Glycero-3-Phosphoethanolamine","4-Oxo-4-(3-Oxodecan-2-Ylamino)Butanoic Acid","Gpcho(20:2/20:5)","Creatinine Aspartate","Ser Leu Arg Glu","Pachymic Acid","P-Tolualdehyde","Tyramine","Gpcho(18:4/16:1)","7A,12A-Dihydroxy-3-Oxo-4-Cholenoic Acid","(R)-1-O-[B-D-Apiofuranosyl-(1->2)-B-D-Glucopyranoside]-1,3-Octanediol","4-Deoxyphysalolactone","(10S,11S)-Pterosin C","Cuniloside","Urea Glutamate","Gly-Val","Pgp(Pgf2Alpha/I-12:0)","Melezitose","Formononetin","Gly-Pro-Arg-Pro-Lys","Norfenefrine","Ergothioneine","Lapidin","Lpc(19:0-Sn1)","13-Hdohe","O-Stearoylcarnitine","Pc(20:5/0:0)","Desoxycortone","Pc(32:2)","1-O-Palmitoyl-2-O-Acetyl-Sn-Glycero-3-Phosphorylcholine","Paramethasone","4-Hydroxy-3-(4-Hydroxy-3,7,11-Trimethyldodeca-2,6,10-Trienyl)Benzoic Acid","Kynurenine","Choline Glycerophosphate","Gpcho(18:2/18:1)","Pe(Dime(9,5)/Pgd2)","6-((8Z,11Z,14Z)-Heptadeca-8,11,14-Trien-1-Yl)Salicylic Acid","Cyclo[Dha-Unk-Dl-Val-Dl-Xithr]","Cocamidopropyl Betaine","O-Acetylcarnitine","Platelet-Activating Factor","Nan-190 Hydrobromide","12-[(Cyclohexylcarbamoyl)Amino]Dodecanoic Acid","Sm(D15:0/18:1)","7-Ketodeoxycholic Acid","5-Chloro-2-[(3S)-1-(3,4-Difluorobenzyl)-3-Pyrrolidinyl]-1,3-Benzoxazole","His Val Trp","Gpcho(18:1/18:1)","L-Glutamine","Choline","Dispiro[1H-Perimidine-2(3H),1'-Cyclohexane-4',2(3H)-[1H]Perimidine]","Minoxidil Glucuronide","N-(2,6-Dimethylphenyl)-2-Hydroxyacetamide","Lpc(20:0)","1-(4-Pyrimidin-2-Ylpiperazin-1-Yl)-3-(1,3,5-Trimethylpyrazol-4-Yl)Propan-1-One","(12Z)-10-Hydroxyoctadecenoylcarnitine","L-Menthyl (R,S)-3-Hydroxybutyrate","2-Amino-4-Methylpyridine","2-Amino-2-Methylpropan-1-Ol","2',3'-Dideoxyadenosine","L-Isoleucine","D-Erythro-Sphingosine C-15","Eicosapentaenoic Acid Ethyl Ester","Indoline","Tirofiban","Bicyclo Prostaglandin E2","2-Cyclotetradecen-1-One","N-Cycloheptyl-1-[3-(Trifluoromethyl)Quinoxalin-2-Yl]Piperidine-4-Carboxamide","4-Hydroxytrideca-6,8-Dienoylcarnitine","Beta-Micropteroxanthin","Urceolide","(5E,7E)-3-Aminoundeca-5,7-Dienoic Acid","Sebacic Acid","Docosahexaenoic Acid Methyl Ester","2-Aminopurine","Allyl Hexanoate","3-Aminonon-5-Enoic Acid","2-Acetamido-3-Phenylpropanol","Ile Phe Met","Palmitoylcarnitine","Pc(Pgf2Alpha/14:1(9Z))","Staphyloxanthin","S-Triazine, 2-Amino-4-((4-Methyl-1-Piperazinyl)Methyl)-6-Piperidino-","N'-(2-Cyano-3-Fluoro-N-Methylanilino)Ethanimidamide","Lyso-Pc(18:0)","Gpcho(18:2/18:2)","Pa(Pgf2Alpha/A-21:0)","Betavulgaroside Ii","Heptadecasphinganine","Gpcho(16:0/16:1)","Gemcitabine","Esculentoside A","Decanoyl-L-Carnitine","Nordihydrocapsaicin","N-Myristoyl Tyrosine","3-Hydroxybutyrylcarnitine","Baccatin","Gpcho(20:3/20:3)","3-Beta-Acetoxyallopreg-16-En-20-One","7,15-Dihydroxyabieta-8,11,13-Triene-18-Oic Acid","N-[4-[1-(3-Methylpiperidine-1-Carbonyl)Cyclohexyl]Phenyl]Ethanesulfonamide","3,7,8,15-Scirpenetetrol","Lpc(24:2-Sn1)","Piperidine","Dimethyl Fumarate","Vapiprost","(1R)-Trans-Phenothrin","Hydroxytetradecadienyl-L-Carnitine","Filipin Ii","Trimethylamine N-Oxide","Phosphocholine","12-Hydroxyjasmonic Acid","Trp Ser Phe","Pe(O-9:0/7:0)","Cetylmannoside","Gpcho(20:4/20:3)","2-Aminoacetophenone","Taurodeoxycholic Acid","Gpcho(18:3/18:3)","Skimmin","4-Ketoniridazole","Gpcho(22:6/20:5)","Indole-3-Carbinol","Deoxyinosine","Cis-4-Heptenal","Pe(O-18:5/2:0)","N6,N6,N6-Trimethyl-L-Lysine","Indole-3-Acetic Acid","Chlorobenzene","Beta-Casomorphin-5","Dihydroprogesterone","Gln-Ile-Lys","Anisperimus","Pc(24:0/0:0)","L-Proline","Hydromorphone","Urea","Phenol","Gpcho(20:4/16:0)","2-Methylbutyroylcarnitine","Pe(O-16:4/4:0)","5-(Hydroxyphenyl)-Gamma-Valerolactone-O-Sulphate","N1-Acetylspermidine","Ingenol","Hyocholic Acid","Rotigaptide","Tyr Pro Gln","2-Aminooctanoic Acid","Dg(O-18:3/18:0)","Butyrylcarnitine","3-Ketocholanic Acid","1-Aminocyclopropane-1-Carboxylate","3-[4-(2-Ethyl-1,3-Thiazol-4-Yl)Phenyl]-5-Pyridin-4-Yl-1,2,4-Oxadiazole","Cannabinol","N-[1-(4,6-Dimethylpyrimidin-2-Yl)Piperidin-4-Yl]Quinoxaline-5-Carboxamide","(+/-)-Tryptophan","7-Hydroxydecanoylcarnitine","2-((3-Ethoxy-3-Oxopropanoyl)Oxy)-N,N,N-Trimethylethan-1-Aminium","Pro Arg Lys","Bisnoryangonin","Fusaric Acid","Karakoline","Farnesol","1-Hexadecanoyl-Sn-Glycero-3-Phosphoethanolamine","Crustacean Erythrophore Concentrating Hormone","Glu Arg","Spb(20:0_2O)","Gpcho(18:3/20:5)","Sulfonamidoethanol","Cysteineglutathione Disulfide","Tg100-115","Secoisolariciresinol-Sesquilignan","Propylene Glycol","Cytochalasin B","Pc(P-18:0/16:1)","Pc(P-16:0/22:5)","12-Oxo-C-Ltb3","Lpc(O-20:0)","Macimorelin","Phytolaccatoxin","Sm(D16:1/16:0)","Gpcho(7:0/7:0)","Tetradecadienyl-L-Carnitine","Gpcho(22:5/15:0)","N-(Oxan-4-Yl)-N-[1-(4-Propan-2-Ylphenyl)Sulfonylpiperidin-4-Yl]Propanamide","1-(3-Chloro-2-Methylphenyl)-3-[2-(1-Ethylpyrrolo[2,3-B]Pyridin-3-Yl)Ethyl]Urea","Biliverdin","Pc(O-20:0/0:0)","N,N-Dimethylsphingosine","(2R,3Z)-Phycocyanobilin","25-Hydroxycholecalciferol","Gpetn(20:4/22:6)","(1(10)E,4A,5E)-1(10),5-Germacradiene-12-Acetoxy-4,11-Diol","12(S)-Leukotriene B4","2-Methylindole","N-Arachidonoyl Phenylalanine","4-Methylaminomethyl-Quinolin-2-Ol","7-Hydroxychroman-2-One","2-[4-(Dimethylamino)Phenyl]-N-(2-Methylphenyl)Imidazo[1,2-A]Pyrimidin-3-Amine","5-Hete Lactone","Pi(40:7)","Curdione","Peg N14","Vitamin D3 Glucosiduronate","Peg N12","Brefeldin A","Dihydroceramide C2","3A-Hydroxydesogestrel","Pe(22:1/0:0)","(3Beta,5Alpha,9Alpha,22E,24R)-3,5,9-Trihydroxy-23-Methylergosta-7,22-Dien-6-One","N-Arachidonoyl Arginine","Val-Thr-Lys","4-Oxo-2-Nonenal","6-Nonenoylglycine","Diethanolamine","Linoleoyl Carnitine","9-Methylchromeno[4,3-B]Quinolin-6-One","2-[(2E)-6-Hydroxy-3,7-Dimethylocta-2,7-Dienyl]-5-(2-Phenylethyl)Benzene-1,3-Diol","N,N-Diisopropylethylamine","4-Ethynylaniline","Pe(20:0/0:0)","Alpha-Methylene-Gamma-Butyrolactone","Pi(Pgf1Alpha/16:0)","Tetradecyldiethanolamine","Pc(18:2/0:0)","4-Methoxy-Alpha-Ethylaminovalerophenone","Gpcho(22:6/20:4)","Neoeriocitrin","Ly-310,762 Hydrochloride","(12E)-10-Hydroxytetradec-12-Enoylcarnitine","Pc(20:4/0:0)","Fenoprofen Glucuronide","Acetoacetic Acid","L-Tyrosine","6-Hydroxyangolensic Acid Methyl Ester","Uric Acid","Glu-Trp","4-Methyl-1H-Benzotriazole","Ethyl Chrysanthemate","Myotoxin A","N-Acetyl-D-Glucosaminyldiphosphodolichol","Nap-Phe-Oh","Pinolenic Acid","Clarithromycin","Pa(Pgj2/I-16:0)","Ldgts(14:0)","5-Phenylvaleric Acid","(2E,4E)-N-(1-Hydroxy-3-Methylpentan-2-Yl)-2-Methylhexa-2,4-Dienamide","2-(1,3-Benzodioxol-5-Yl)-5-Methyl-1,3,4-Oxadiazole","Hexadecanedioic Acid Mono-L-Carnitine Ester","N-[4-(2-Morpholin-4-Yl-2-Oxoethyl)Phenyl]Furan-2-Carboxamide","N-Isobutyloctadeca-Trans-2-Trans-4-Dienamide","Spermidine","5-Chloro-6-Methoxymellein","2-Hydroxycinnamic Acid","Gln-Ile-His","Lithocholate 3-O-Glucuronide","(6Beta,7Alpha,12Beta,13Beta)-7-Hydroxy-11,16-Dioxo-8,14-Apianadien-22,6-Olide","Aflatoxin M1","Metolachlor Morpholinone","Ldgts(14:1)","Phaseolotoxin","Roseoside A","Pseudoginsenoside Rt3","Propionylcarnitine","Batrachotoxinin A 20-Alpha-Benzoate","Chamazulene","3,7-Dihydropurin-6-One","1-[[1-(2,3-Dihydro-1H-Inden-5-Ylsulfonyl)Piperidin-4-Yl]Methyl]Azepane","Formacidine","Phthalamic Acid","Ile-Gln-Lys","Afalanine","(S)-2-Tert-Butoxycarbonylamino-5-Guanidinopentanoic Acid","Naorn(26:5/13:1)","Asn-Val-Leu","Mammeisin","N-(3-Chloro-4-Methylphenyl)-2-(5-Pyrazin-2-Yl-1,3,4-Oxadiazol-2-Yl)Acetamide","Octadecanamide","Cyclohexanone","Benzoic Acid","D-Pyroglutamic Acid","Erucic Acid","1-Naphthyl Beta-D-Glucuronide","Pe(P-16:0/0:0)","Creatinine","N-Acetyl-L-Alanine","3,17,20-Trihydroxypregnane","7Alpha-Hydroxy-3-Oxochol-4-En-24-Oic Acid","Gpcho(18:3/22:4)","9,10-Epoxy-18-Hydroxy-Octadecanoic Acid","Lpc(24:1-Sn1)","5-Acetoxydihydrotheaespirane","(6S)-Tetrahydro-L-Biopterin","2-Phenylacetamide","Ethyl 4-(Benzylcarbamoylamino)Benzoate","Ser-Thr-Ala","5'-Deoxy-5'-Methylthioadenosine","Lysopc(15:0)","Gpcho(22:6/17:0)","Rhinocerotinoic Acid","Disperse Red 60","3-Hydroxytetradecanoyl Carnitine","Cortisol","Bilirubin","Sterebin B","5-(3-Fluorophenyl)-3-[1-[(3-Fluorophenyl)Methyl]Triazol-4-Yl]-1,2,4-Oxadiazole","N-[(3,5-Difluorophenyl)Methyl]-2-(3-Phenylpiperazin-1-Yl)Pyridine-4-Carboxamide","2-Aminoindan-2-Carboxylic Acid","Sterebin A","Betaine","N-Methyl-L-Proline","L-Alanine","Atpa","Gamma-Glu-Epsilon-Lys","Benzoic Aldehyde","Pipecolic Acid","N-Epsilon-Acetyl-L-Lysine","4-{5-[(3S)-1-Isopropyl-3-Pyrrolidinyl]-1,3,4-Oxadiazol-2-Yl}Pyridine","Pa(6 Keto-Pgf1Alpha/21:0)","Pelargonidin","Grayanotoxin","Cytidine","Gpetn(20:4/20:4)","Dehydrovomifoliol","Gpcho(2:0/18:4)","(-)-Epigallocatechin 3-Glucuronide","7',8'-Dihydro-8'-Hydroxyreticulataxanthin","Pe(O-16:3/2:0)","Pe(Dime(11,3)/22:6(4Z,8Z,10Z,13Z,16Z,19Z)-Oh(7))","Isoquinoline","Mesobilirubinogen","L-Lysine","1-Phenylpropane-1,2-Dione","Cyclopassifloic Acid B","3-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-Hydroxyprop-2-Enimidamide","Osimertinib","8-Acetoxyelemol","Gpcho(2:0/18:3)","3-Benzyl-6-Pyridin-4-Yl-2-Pyrrolidin-1-Ylpyrimidin-4-One","Peg N7","Gpcho(16:1/20:4)","Endomorphin-2","Sphinganine","Cer(8:1_2O/5:0)","1-Methoxyindole-3-Carboxylic Acid","Lpc(16:2-Sn1)","Amylopectin","Butirosina","Pc(Txb2/P-16:0)","22-Hydroxydocosanoic Acid","(R)-2',4',7-Trihydroxy-3',8-Diprenylisoflavan","3-Methylcatechol","Tert-Butyl 4-[4-Amino-5-(Benzylcarbamoyl)Pyrimidin-2-Yl]Piperazine-1-Carboxylate","Ala-Pro-Lys","Asi-222","Amphotericin B","Pgp(5-Iso Pgf2Vi/I-14:0)","Kemptide","Velvione","Kioukasin A","Perillic Acid","Tsangane L 3-Glucoside","7-O-Demethyl Rapamycin","L-Saccharopine","Pc(18:3/0:0)","Ldgcc(13:0)","Netilmicin","Meranzin Hydrate","Pc(22:0/0:0)","[(3S,4R)-1-[(2,6-Dimethoxyphenyl)Methyl]-4-Pyridin-4-Ylpyrrolidin-3-Yl]Methanol","3-Hydroxy-5,5,8A-Trimethyl-3,4,4A,6,7,8-Hexahydronaphthalene-2-Carboxylic Acid","Gibberellin A14","Lauroylcarnitine","Pg(5-Iso Pgf2Vi/I-14:0)","(+/-)-Hexanoylcarnitine","Limazocic","N-[3,5-Bis(Trifluoromethyl)Phenyl]-2-Pyrrolidin-1-Ylacetamide","2'-Deoxycytidine","9-Oxootre","(4-Chlorophenyl) 3-Methyl-1-Oxo-4H-Isochromene-3-Carboxylate","2-Aminobutyric Acid","4-Hydroxyproline","N-Phenyl-3-[1-[6-(Propylamino)Pyrimidin-4-Yl]Piperidin-3-Yl]Propanamide","Ser Leu Leu Ser Phe","Butylisopropylamine","Phenaceturic Acid","11B,13-Dihydrolactucopicrin","Deferoxamine","Lauryldiethanolamine","13,14-Dihydro Pgf-1A","Daunorubicin","1-Stearoylglycerol","Pc(17:1/17:1)","Glyceryl Palmitate","N-Acetyl-D-Glucosamine","Glu-Gln","Bis(2-Ethylhexyl)Adipate","1-(4-Benzyl-3-Oxoquinoxalin-2-Yl)-N-Cycloheptylpiperidine-3-Carboxamide","Phaeophorbide B","Serotonin","Dihydrozeatin","[1-[(3,4-Difluorophenyl)Methyl]Piperidin-4-Yl]-Pyridin-2-Ylmethanol","2-Amino-4-[Carbamimidoyl(Methyl)Amino]Butanoic Acid","N-Hydroxy-2-(2-Thienylthio)Ethanimidamide","Pe(19:0/0:0)","Phosphatidylcholine Lyso 18:0","Inosinic Acid","(8Ar)-7-Benzoyl-2-(3-Pyridinylmethyl)Hexahydroimidazo[1,5-A]Pyrazin-3(2H)-One","Asn-Leu-Leu","Farnesyl Acetone","Phytosphingosine","Isosteviol","Gpcho(20:3/18:2)","N-Acetyl-B-Glucosaminylamine","2-Morpholino-1-Phenylethanol","N-(6-Methoxyquinolin-8-Yl)Alanine","Glu-Ala-Lys","Abiraterone","5-(2-Hydroxy-4-Methylphenyl)-6-Methylheptan-2-One","(All-E)-1,8,10-Heptadecatriene-4,6-Diyne-3,12-Diol","Coumarin","Spermine","Crotonic Acid","Gpetn(16:0/22:6)","Alpha-Estradiol","13E-Docosenamide","Tyr-Pro-Lys","Indole-3-Acetic-Acid-O-Glucuronide","Strophanthidin","Hydroxyrepaglinide","Guanidine, (4-Chloro-3-Methoxy-1-Oxo-1H-2-Benzopyran-7-Yl)-","2,3-Epoxyaflatoxin B1","3-(6-Aminopurin-9-Yl)-5-(Hydroxymethyl)Cyclopentane-1,2-Diol","14-Deoxy-11,12-Didehydroandrographolide","Arg Lys Gln","Notoginsenoside R2","Gln-Leu-Lys","Docosahexaenoyl Ethanolamide","Umbelliferose","Pc(19:0/0:0)","Lycoperoside D","24,25,26,27-Tetranor-23-Oxo-Hydroxyvitamin D3","5-Methyluridine","N-Di-Demethyl Roxithromycin","3-Methylamino-1,2-Propandiol","Ile Ser Val Asp","3-[(1E,3E)-Hepta-1,3-Dienyl]Pentanedioic Acid","Adenine","4-[4-(5-Amino-1,2-Oxazol-3-Yl)Piperidin-1-Yl]Sulfonylbenzonitrile","Alminoprofen","Octanoyl-L-Carnitine","Hexaethylene Glycol","Lumichrome","Gpcho(20:3/18:1)","Dl-O-Tyrosine","Dg(O-18:5/2:0)","4-Formyl Indole","Lauric Isopropanolamide","Tyr Trp Leu","9-Hydroxyoctadeca-2,4-Dienoic Acid","Pc-M5","2,6-Di-Tert-Butyl-P-Benzoquinone","Lpe(18:1)","Prostaglandin F1A","2,5-Dimethylbenzaldehyde","Myristoylcarnitine","1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid","3-Hydroxybenzaldehyde","6-Hydroxytrideca-8,10-Dienoylcarnitine","5-Acetylamino-6-Formylamino-3-Methyluracil","Bis(2-Ethylhexyl) Sebacate","Methyl Indole-3-Acetate","L-Methionine","N-Oleoyl Arginine","Nicotinamide","Oxyglutinosone","O-(17-Carboxyheptadecanoyl)Carnitine","Oxo-Taurocholenic Acid","2-(1-Methylpyrrol-2-Yl)-2-Oxo-N-[2-(Trifluoromethyl)Phenyl]Acetamide","Hexanoyl-L-Carnitine","Methyl Hydrogen Azelate","9-Octadecen-1-Ol, (9Z)-","Lycoperodine I","Nicotyrine","Pc(P-16:0/0:0)","6-O-Oleuropeoylsucrose","Gpcho(20:3/18:4)","N-(4-Chlorophenyl)-2-(6-Pyrrolidin-1-Ylpyridin-3-Yl)-1,3-Thiazole-4-Carboxamide","Methionine Sulfoxide","Menthyl Ethylene Glycol Carbonate","Glu Phe Thr Pro Ala","Pe(O-16:2/2:0)","Tropic Acid","Cibaric Acid","Butyryl Carnitine","Tetrahydroberberine","16-Hydroxy-10-Oxohexadecanoic Acid","6-Methoxy-1-(4-Methoxyphenyl)-4-Oxo-N-Propylpyridazine-3-Carboxamide","N-Decanoylglycine","8-[1-Acetyloxy-4-Oxo-5-(2-Oxopent-3-Enyl)Cyclopent-2-En-1-Yl]Octanoic Acid","9-Octadecynoic Acid","2-(Difluoromethyl)Arginine","Leu-Thr-Asn","Cholylvaline","1,4-Butanediol Diglycidyl Ether","Lpc(22:1-Sn1)","Tranexamic Acid","Glu-Thr","3-Methylglutarylcarnitine","Polyoxyethylene 40 Monostearate","Neryl Acetate","L-2-Aminoadipic Acid","Oleandomycin","Boviquinone 4","8-Hydroxytrtradeca-10,12-Dienoylcarnitine","Gpcho(18:2/19:0)","(4S,8R)-8,9-Dihydroxy-P-Menth-1(6)-En-2-One","11-Hydroxy-9-Tridecenoic Acid","Homodolicholide","Indole-3-Acetyl-L-Alanine","Pc(Dime(11,3)/18:1(12Z)-2Oh(9,10))","Leu Asp Ala","Erucamide","Pa(Pgd1/I-19:0)","Semduramicin","28-Norbrassinolide","Bufalin","Gpcho(18:0/20:4)","Histamine","11-(3-Methyl-5-Pentylfuran-2-Yl)Undecanoylcarnitine","Dhurrin 6'-Glucoside","Lipoteichoic Acid","Lpc(18:4-Sn1)","Leonurine","1,2-Octanoylphosphatidylcholine","6,8-Dihydroxypurine","Hexadecanamide","16-Hydroxyhexadecanoic Acid","(9Z)-Nonadec-9-Enoylcarnitine","Lpc(18:1)","Ascorbyl Palmitate","N-Methyl-L-Serine","Dodecamethylcyclohexasiloxane","Beta,Beta-Dimethylacrylshikonin","Prostaglandin F3A","Avocadene","O-Arachidonoyl Glycidol","7B-Hydroxy-3-Oxo-5B-Cholanoic Acid","Sphinganine 1-Phosphate","Pentaethylene Glycol","Chrysin","Levuglandin D2","Phenylacetic Acid","Typhasterol","3-Hydroxy-4-Aminopyridine Sulfate","5,7-Dihydroxy-11-Ketotetranorprostanoic Acid"],"additional_accession":[]},"is_claimable":false,"name":"Aqueous Artemisia argyi extract mitigates acute lung injury in association with coordinated alterations in gut microbiota, metabolic homeostasis, and pulmonary inflammatory gene expression","description":"Background: Artemisia argyi is a traditional medicinal herb with established anti-inflammatory and immunomodulatory properties. Its aqueous extract (AEAA), enriched in water-soluble bioactive constituents, exhibits favorable safety and bioavailability; however, its potential protective effects against acute lung injury (ALI) and its associations with systemic immunometabolic regulation remain incompletely understood. Methods: An LPS-induced ALI mouse model was established following 28 days of AEAA pretreatment. Lung histopathology, pulmonary edema, and inflammatory cytokines were evaluated. Integrated multi-omics analyses—including gut microbiota profiling, untargeted metabolomics of colonic contents and serum, and lung transcriptomics—were performed to characterize treatment-associated microbial, metabolic, and transcriptional alterations. Results: AEAA pretreatment dose-dependently alleviated lung injury, reduced pulmonary edema, and suppressed pro-inflammatory cytokines while restoring anti-inflammatory IL-10 levels. AEAA treatment was associated with partial reversal of LPS-induced gut dysbiosis, characterized by reduced abundance of inflammation-associated taxa and enrichment of beneficial genera, particularly Akkermansia and Lactobacillus. Metabolomic analyses revealed treatment-associated normalization of intestinal and systemic metabolic disturbances, including increased homeostasis-related metabolites and reduced inflammation-associated metabolites. Lung transcriptomic profiling suggested attenuation of LPS-associated transcriptional signatures related to NF-κB, MAPK, Toll-like receptor, and PI3K–AKT signaling pathways. Cross-omics integration further revealed coordinated associations among microbial shifts, metabolic remodeling, and pulmonary inflammatory gene expression. Conclusion: These findings suggest that aqueous Artemisia argyi extract is associated with mitigation of LPS-induced acute lung injury, accompanied by coordinated alterations in gut microbiota composition, host metabolic profiles, and pulmonary inflammatory gene expression. Although causal relationships were not established, this integrated multi-omics analysis provides a systems-level, hypothesis-generating framework supporting the potential of AEAA as a multi-target botanical candidate for ALI.","dates":{"publication":"2026-03-27","submission":"2026-03-27"},"accession":"MTBLS14160","cross_references":{"HMDB":["HMDB0029884","HMDB0251511","HMDB0034267","HMDB0000168;PW_C000110","HMDB0000904;PW_C000723","HMDB0006899","HMDB0000462","HMDB0060649","HMDB0000156;PW_C000101","HMDB0000355","HMDB0155722","HMDB0004992","HMDB0000139;PW_C000090","HMDB0000273;PW_C000187","HMDB0029104","HMDB0000767","HMDB0000532","HMDB0029126","HMDB0000292;PW_C000198","HMDB0039875","HMDB0000781","HMDB0000226;PW_C000151","HMDB0249899","HMDB0258943","HMDB0001296","HMDB0000094;PW_C000063","HMDB0000005","HMDB0060712","HMDB0015652","HMDB0000620;LMFA01170109","HMDB0003213;PW_C001805","HMDB0000254;HMDB0303309;LMFA01170043;PW_C000174","HMDB0000208","HMDB0040198","HMDB0003345;PW_C001851","HMDB0000157;PW_C000102","HMDB0000210;HMDB0250782;PW_C000136","HMDB0001511","HMDB0012210","HMDB0246328","HMDB0029073","HMDB0304914","HMDB0041718","HMDB0011171","HMDB0060013","HMDB0257721","HMDB0247945","HMDB0247171","HMDB0041738","HMDB0041832;LMPK12111081","HMDB0037584","HMDB0013676","HMDB0035701","HMDB0040713","HMDB0246889","HMDB0042049","HMDB0034782","HMDB0000701","HMDB0000953","HMDB0011756","HMDB0240524","HMDB0031308","HMDB0000959","HMDB0000678","HMDB0011658","HMDB0029383","HMDB0030452","HMDB0000714;HMDB0011723;HMDB0000714","HMDB0240547","HMDB0062723","HMDB0028848","HMDB0240659","HMDB0060484","HMDB0002275","HMDB0000559","HMDB0015544","HMDB0258290","HMDB0013713","HMDB0240525","HMDB0240436","HMDB0037851;LMPK12110431","HMDB0303451","HMDB0030434","HMDB0029306","HMDB0041768","HMDB0059996","HMDB0061643","HMDB0008072","HMDB0000784;LMFA01170054","HMDB0001544","HMDB0013105","HMDB0257486","HMDB0061147","HMDB0303810","HMDB0030326","HMDB0040451","HMDB0010397","HMDB0060169","HMDB0033778","HMDB0002327;LMFA01170014","HMDB0288795","HMDB0011478","HMDB0242256","HMDB0000502","HMDB0000872;LMFA01170018","HMDB0247056","HMDB0037377","HMDB0003252;PW_C001820","HMDB0253585","HMDB0001238;PW_C000956","HMDB0254692","HMDB0255420","HMDB0034099","HMDB0256138","HMDB0038736","HMDB0000399","HMDB0035987","HMDB0031342","HMDB0060139","HMDB0001939","HMDB0284796","HMDB0012868","HMDB0252416","HMDB0034634","HMDB0257435","HMDB0282766","HMDB0242561","HMDB0249052","HMDB0304442","HMDB0304821","HMDB0000734","HMDB0000888;LMFA01170007","HMDB0039858","HMDB0252457","HMDB0008944","HMDB0010211;LMFA03060078","HMDB0304915","HMDB0002205","HMDB0303799","HMDB0000138;LMST05030001;PW_C000089","HMDB0032662","HMDB0002710;PW_C001687","HMDB0243886","HMDB0303926","HMDB0039156","HMDB0244153","HMDB0037798","HMDB0256697","HMDB0253305","HMDB0001066","HMDB0259530","HMDB0060037","HMDB0004160","HMDB0005998;LMFA03060009","HMDB0031864","HMDB0004482","HMDB0252653","HMDB0001852;HMDB0012874;LMPR01090019","HMDB0256958","HMDB0250835","HMDB0003312;LMPK12050038","HMDB0001908","HMDB0244272","HMDB0000619;LMST04010001;PW_C000480","HMDB0012458","HMDB0245492","HMDB0242403","HMDB0029858","HMDB0060319","HMDB0014511;LMST02030119","HMDB0244806","HMDB0258432","HMDB0242067","HMDB0006111;HMDB0244455;LMFA03060088","HMDB0008046","HMDB0289104","HMDB0062566","HMDB0255144","HMDB0009795","HMDB0003533","HMDB0033244","HMDB0011352","HMDB0255670","HMDB0010383","HMDB0011474","HMDB0001043;LMFA01030001;PW_C000821","HMDB0007852","HMDB0247617","HMDB0029384","HMDB0011661","HMDB0248574","HMDB0245144","HMDB0000733;LMST04010024","HMDB0264817","HMDB0060383","HMDB0249573","HMDB0003128","HMDB0254402","HMDB0001999;PW_C001337","HMDB0010343","HMDB0256834","HMDB0256465","HMDB0010564;LMGP02010326;PW_C006572","HMDB0289522","HMDB0248622","HMDB0253207","HMDB0256043","HMDB0009005","HMDB0010392","HMDB0010395","HMDB0249467","HMDB0011483","HMDB0000353","HMDB0039133","HMDB0242066","HMDB0061695","HMDB0060464","HMDB0008943","HMDB0248575","HMDB0011517","HMDB0242383","HMDB0008842","HMDB0304033","HMDB0285468","HMDB0061167","HMDB0288986","HMDB0004667","HMDB0006886","HMDB0007969","HMDB0008994","HMDB0256345","HMDB0008876","HMDB0243883","HMDB0008048","HMDB0008156","HMDB0009111","HMDB0268341","HMDB0284852","HMDB0008304","HMDB0005780","HMDB0007973","HMDB0259856","HMDB0288948","HMDB0284995","HMDB0258879","HMDB0008037","HMDB0240601","HMDB0250369","HMDB0012108","HMDB0241962;LMFA08020116","HMDB0007850","HMDB0285369","HMDB0289148","HMDB0256231","HMDB0039761","HMDB0254187","HMDB0033960","HMDB0281245","HMDB0251719","HMDB0250404","HMDB0251539","HMDB0002183;PW_C001472","HMDB0241935","HMDB0240600","HMDB0008006","HMDB0008090","HMDB0059915","HMDB0240629","HMDB0240597","HMDB0061693","HMDB0259781","HMDB0009027","HMDB0009786","HMDB0008004","HMDB0240602","HMDB0009691","HMDB0007991","HMDB0258207","HMDB0007958","HMDB0015418","HMDB0008946","HMDB0250319","HMDB0250439","HMDB0010386","HMDB0036791","HMDB0285371","HMDB0009408","HMDB0011343","HMDB0303056","HMDB0011628","HMDB0007980","HMDB0010387","HMDB0036579","HMDB0010391","HMDB0008057","HMDB0247616;LMFA02000280","HMDB0302940","HMDB0251106","HMDB0253989","HMDB0242656","HMDB0241979","HMDB0002177","HMDB0259259","HMDB0007984","HMDB0061659","HMDB0257880","HMDB02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