MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14199/m_MTBLS14199_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14199/m_MTBLS14199_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14199/a_MTBLS14199_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14199/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14199/a_MTBLS14199_LC-MS_positive_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14199/s_MTBLS14199.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14199<p>After sum normalization, the data were subjected to multivariate statistical analysis using the R package ropls, including Pareto-scaled principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA). Model robustness was evaluated using 7-fold cross-validation and response permutation testing. The variable importance in projection (VIP) values from the OPLS-DA model were calculated to assess the contribution of each variable to classification. Differences between two independent groups were assessed by Student's t-test, with selection criteria set as VIP &gt; 1 and p-value &lt; 0.05. Correlations between variables were evaluated using Pearson correlation analysis.</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phase<p>Ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF MS) analysis was performed at Shanghai Applied Protein Technology Co., Ltd., using an ultra-high-performance liquid chromatography system (1290 Infinity LC, Agilent Technologies) coupled with a quadrupole time-of-flight mass spectrometer (AB Sciex TripleTOF 6600).</p><p>Hydrophilic interaction liquid chromatography (HILIC) separation was performed on a 2.1 mm × 100 mm ACQUITY UPLC BEH Amide 1.7 μm column (Waters, Ireland). In both positive and negative electrospray ionization (ESI) modes, mobile phase A consisted of 25 mM ammonium acetate and 25 mM ammonium hydroxide in water, and mobile phase B was acetonitrile. The gradient elution program was as follows: 95% B was maintained for 0.5 minutes, linearly decreased to 65% over 6.5 minutes, then decreased to 40% within 1 minute and held for 1 minute, increased to 95% within 0.1 minutes, and finally equilibrated for 3 minutes.</p>Jiawei Shoutai Pill Promotes Embryo Implantation via PPAR Signaling and Endometrial Microbiota Remodeling: An Integrative Multi-Omics Study.Yi ZhangThe Affiliated Hospital of Shandong University of Traditional Chinese Medicineserummass spectrometry assay<p>Fasting blood samples were collected into 5 mL vacuum tubes containing the chelating agent ethylenediaminetetraacetic acid (EDTA) and then centrifuged at 1,500 × g for 15 minutes at 4 °C. A 150 μL aliquot of plasma was separated and stored at −80 °C until liquid chromatography-mass spectrometry (LC-MS) analysis. Prior to analysis, plasma samples were thawed at 4 °C, and 100 μL was mixed with 400 μL of pre-cooled methanol/acetonitrile (1:1, v/v) for protein precipitation. The mixture was centrifuged at 14,000 × g for 20 minutes at 4 °C, and the supernatant was dried in a vacuum centrifuge. The dried residue for LC-MS analysis was reconstituted in 100 μL of acetonitrile/water (1:1, v/v), centrifuged at 14,000 × g for 15 minutes at 4 °C, and the supernatant was injected for analysis.</p>Rattus norvegicus<p>Raw mass spectrometry data were converted to mzXML format using ProteoWizard MSConvert and subsequently imported into the open-source software XCMS for peak extraction. Peak extraction parameters were set as follows: centWave with m/z deviation of 10 ppm, peak width range of 10–60 seconds, and prefilter threshold (10, 100). Peak grouping parameters were set as bandwidth (bw) 5, m/z width (mzwid) 0.025, and minimum fraction (minfrac) 0.5. Isotope and adduct annotation was performed using CAMERA (Collection of Algorithms for METabolite pRofile Annotation). For extracted ion features, only variables with non-zero measurements in more than 50% of samples in at least one group were retained. Metabolite identification was performed by comparing accurate mass (deviation &lt;10 ppm) and tandem mass spectrometry spectra against an in-house standard library.</p>Treatmentzhangyi951006@163.comhttps://www.ebi.ac.uk/metabolights/MTBLS14199<p>JWSTW is composed of seven medicinal herbs: Tu Si Zi, E Jiao, Sang Ji Sheng, Xu Duan, Dan Shen, Dang Gui, and Xiang Fu. Seven-week-old Sprague-Dawley (SD) rats were used in the experiment and housed in the specific pathogen-free (SPF) animal facility. A rat model of EID was established via subcutaneous injection of a mifepristone oil solution into the neck region. After one week of adaptive feeding, female rats with regular estrous cycles were selected. At 5:00 PM daily, female and male rats were housed together at a ratio of 2:1. The following morning at 7:00 AM, vaginal smears were collected from the female rats. The presence of sperm in the smear was designated as gestational day 1. The mated female rats were randomly divided into different groups: the control group and the JWSTW group(in which rats were orally administered JWSTW of 8.4 g/kg). The model group were administered an equal volume of sterile water by gavage. All female rats were administered mifepristone for modeling on the morning of gestational day 4. Female rats were subjected to oral gavage daily at 9:00 AM from day 1 to day 6 of gestation. On gestational day 6, 1 hour after oral administration, rats were anesthetized with an intraperitoneal injection of 1 % pentobarbital, and then whole blood were collected.&nbsp;</p>MetabolomicsMetabolomicsEndometrialPPAR Pathwayuntargeted analysisNetwork PharmacologyRattus norvegicusserumAB SCIEX TripleTOF 6600untargeted metabolite profilingAgilent 1290 Infinity UHPLCMetabolomicsEndometrialPPAR Pathwayuntargeted analysisNetwork PharmacologyRattus norvegicusserumAB SCIEX TripleTOF 6600untargeted metabolite profilingAgilent 1290 Infinity UHPLC<p>The ESI ion source parameters were set as follows: ion source gas 1 (Gas1) at 60, ion source gas 2 (Gas2) at 60, curtain gas (CUR) at 30, ion source temperature at 600 °C, and ion spray voltage floating (ISVF) at ±5500 V. The full-scan acquisition mass range was set to m/z 60–1000 Da, with a time-of-flight mass spectrometry (TOF MS) scan accumulation time of 0.20 s per spectrum. For auto MS/MS acquisition, the mass range was set to m/z 25–1000 Da, with a product ion scan accumulation time of 0.05 s per spectrum. Product ion scanning was performed using information-dependent acquisition (IDA) in high-sensitivity mode, with the following parameters: collision energy (CE) fixed at 35 V (±15 eV), declustering potential (DP) at +60 V (positive ion mode) and –60 V (negative ion mode), isotopic ions within 4 Da were excluded, and 10 candidate ions were monitored per cycle.</p>16-Hydroxypalmitic acidTaurineAllantoinCorticosteroneArachidic acidsn-Glycerol 3-phosphoethanolaminePyrocatecholProbucolLithocholic acid.gamma.-linolenic acidEthylenediaminetetraacetic acidGlu-LeuDL-Mandelic acidGamma-l-glutamyl-l-glutamic acidPantothenolD-GalactarateKynurenic acid4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acidThiamine monophosphateN-Acetyl-Asp-GluSuccinateD-glucosamine 1-phosphate1-stearoyl-2-hydroxy-sn-glycero-3-phosphoethanolamineN-Acetyl-D-glucosaminePorphobilinogenD-erythro-sphingosine-1-phosphateCapric acidPhenolHboa + o-hexDL-tryptophan5.alpha.-androstan-3.beta.-ol-17-one sulfate5-L-Glutamyl-L-alaninealpha-Tocopherol (Vitamin E)D-myo-inositol-3,4,5,6-tetraphosphateCholesteryl sulfateTazarotenic acidL-methionineEthyl glucuronideEthyl sulfateL-AsparagineL-citrullineIle-ProGentisic acidOleic acidGlutaric acidBeta-hydroxybutyrate1,2-dioleoyl-sn-glycero-3-phosphateZoledronic acid3-dehydroepiandrosterone sulfateCis,cis-muconic acidPentadecanoic acidShikimateGlu-GlnPhenylalanineTetrahydrocorticosteroneCinchonineGalactinolPseudouridineEstrone glucuronidePantothenateCyclohexanesulfamic acidPsoralidinDl-a-hydroxybutyric acid(+)-catechinN-formylmethionine(2-aminoethoxy)[2-[docosa-4.7.10.13.16.19-hexaenoyloxy]-3-[octadeca-1.9-dien-1-yloxy]propoxy]phosphinic acidAnetholeL-ValineUracilGlycerol 3-phosphateIndolelactic acid2'-deoxyuridine 5'-monophosphateMethoxycinnamic acidTaurocholate20-hydroxyarachidonic acid4-pyridoxic acidPristanic acid2,7,8-trimethyl-2-(.beta.-carboxyethyl)-6-hydroxychromanErucic acid1h-indole-3-propanoic acid3-hydroxyisovaleric acidGlu-HisAcetoacetic acidIndoleacrylic acidGlyceric acidXanthosine 5'-monophosphatePhenaceturic acidFlurbiprofenL-homocysteic acid3-hydroxyglutaric acid21-Hydroxypregnenolone3-(3-Hydroxyphenyl)propanoic acid3-methoxy-4-hydroxyphenylglycol sulfateL-FucoseProstaglandin e3Arachidonic acid (peroxide free)1-stearoyl-2-linoleoyl-sn-glycero-3-phosphocholineD-(+)-mannoseL-threonate1-oleoyl-sn-glycero-3-phosphoethanolamineMalatePregnenolone sulfateMyristic acidL-Gulonic gamma-lactoneUridinePhenyllactic acidHippuric acidAndrosterone glucuronide4-hydroxytamoxifen1-stearoyl-2-myristoyl-sn-glycero-3-phosphocholineIndoleProlineCis-aconitatetrans-cinnamateAspartic acid(4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,1 6,19-Docosahexaenoic acid1,5-anhydro-d-sorbitolEstrone sulfate2-methyl-3-hydroxybutyric acidPhenyl glucuronidePyruvateN-acetyl-l-tyrosineUric acidN-propyl gallateGuanidoacetic acidFructoseLinoleic acidD-ProlineHeptadecanoic acidketoisocaproic acid2-mercaptobenzothiazoleP-coumaric acidGlutamineDL-threonineBenzoic acid7-ethyl-10-(4-n-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin3-Hydroxycapric acidN-acetyl-l-methionineCysteine-s-sulfateTetradecanedioic acidCholic acidPalmitic acidHydroxysebacic acidErythritolHistidine4-hydroxybenzoateMelibioseAnserineS-lactoylglutathioneConiferyl aldehyde1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholineMethotrexateD-gluconateNervonic acidRibitolL-IditolDihydrouracilMelezitoseP-acetamidophenyl .beta.-d-glucuronideL-kynurenineN-Acetyl-D-Glucosamine 6-PhosphateHomovanillic acid sulfateGlutamic acid4-phenylbutyric acidGalactonic acidPyridoxal 5'-phosphate1,2-distearoyl-sn-glycero-3-phospho-l-serineD-MannitolAlpha-ketoisovaleric acid3-methylcrotonylglycineD-Aspartic acidHydroxyphenyllactic acidGamma-Glu-CysSalicylic acidMyo-inositolDodecanedioic acidIsomaltoseXanthosineAll-trans-4-hydroxyretinoic acidN-.alpha.-acetyl-l-ornithine3-hydroxykynurenine1,2-benzenedicarboxylic acidN-Acetyl-L-alanineL-gulono-1,4-lactoneHydroxyisocaproic acidN-acetylglutamineD-arabinonic acidGlycocholic acidOrotateOctadecanoic acidHis-CysL-AlanineStachyose(2-aminoethoxy)[2-[docosa-4.7.10.13.16.19-hexaenoyloxy]-3-[hexadec-1-en-1-yloxy]propoxy]phosphinic acidMitoxantroneOrotidineJasmonic acidIsobutyrylglycineIndoxyl sulfate2'-Deoxy-D-ribose3-hydroxyoctanoic acidCinnamoylglycineThromboxane b2PhosphorylcholineL-hydroxyarginineCytidine1-Salicylate glucuronide1-stearoyl-2-hydroxy-sn-glycero-3-phosphocholineDeoxythymidine 5'-phosphate (dTMP)Dihydroisoferulic acidAtorvastatinGuanidinopropionic acidPyruvaldehydeIsovalerylglycine2-Oxoadipic acidGenisteinMitragynineTaurochenodeoxycholateLeucineDodecanoic acid16-hydroxyhexadecanoic acid2-hydroxymyristic acidRaffinoseCis-9-palmitoleic acid3,4-dihydroxyhydrocinnamic acid1-stearoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamineDihydrothymineL-CarnosineUrocanateCurcuminHis-serGlutathione, oxidizedSalicyluric acidD-Tagatose2-aminoadipic acidThymineFarrerolGlycerophosphate(2)BiocytinDeoxycholic acidN-acetylhistidineN-Acetylglucosamine 1-phosphateQuinateEstrone-3-glucuronideD-RiboseTaurolithocholic acid sulfateGlycodeoxycholic acidSarcosineVitamin cN-acetyl-l-phenylalanineMestranolfalseJiawei Shoutai Pill Promotes Embryo Implantation via PPAR Signaling and Endometrial Microbiota Remodeling: An Integrative Multi-Omics StudyBackground: Recurrent implantation failure (RIF) remains a major barrier to successful assisted reproductive technology, given the lack of effective, mechanism-informed interventions to enhance endometrial receptivity. Jiawei Shoutai Wan (pills) (JWSTW), a modified formulation of the classic Shoutai Pill (STP) used in reproductive medicine, has not been systematically evaluated in the treatment of RIF, and its bioactive components and molecular targets remain largely unclear. Purpose: To determine whether JWSTW improves implantation competence and to identify the pathways associated with its effects. Materials and methods: A mifepristone-induced embryo implantation dysfunction (EID) rat model was established to evaluate implantation outcomes, uterine histology, and markers of endometrial receptivity and vascular perfusion. Bulk uterine transcriptomics and peripheral blood serum untargeted metabolomics were integrated with liquid chromatography-tandem mass spectrometry (LC-MS) based component profiling, network pharmacology, multi-omics correlation analysis, uterine cavity microbiota profiling and structure-based computational analyses. Key pathway molecules were further assessed using targeted molecular experiments. A retrospective cohort of RIF patients undergoing assisted reproduction was analyzed for ultrasound-derived endometrial receptivity parameters before and after treatment. Results: JWSTW administration improved implantation outcomes in EID rats, characterized by the upregulation of multiple receptivity- and perfusion-associated tissue markers. Integrated multi-omics analyses identified peroxisome proliferator-activated receptor (PPAR) signaling and lipid metabolism as significantly enriched pathways, supported by corresponding gene-metabolite correlations. JWSTW was also associated with structured changes in the uterine cavity microbiota, with enriched taxa and predicted functions aligned with lipid metabolism related pathways. LC-MS/MS characterization identified sweroside and loganic acid as major circulating constituents, while computational analyses prioritized a PPAR-centered target network with favorable binding affinity and structural stability. In the retrospective RIF cohort (n = 100), JWSTW was associated with increased endometrial thickness and improved Doppler-derived perfusion indices. Conclusion: These findings support JWSTW as a mechanism-informed candidate to improve endometrial receptivity in implantation failure via a PPAR-lipid metabolism axis.2026-03-312026-03-31MTBLS14199HMDB0000852HMDB0000112HMDB0003869HMDB0034221HMDB0000244HMDB0000367HMDB0002013HMDB0010407HMDB0011262HMDB0011253HMDB0013122HMDB0036458HMDB0010390HMDB0010398HMDB0012108HMDB0010405HMDB0003331HMDB0000001/HMDB0000479HMDB0000699HMDB0010379HMDB0008097HMDB0007991HMDB0011503HMDB0007973HMDB0007965HMDB0007102HMDB0010382HMDB0010381HMDB0009815HMDB0012383HMDB0007098/HMDB0007099/HMDB0007100/HMDB0007101/HMDB0007103/HMDB0007108/HMDB0007112/HMDB0007131/HMDB0007132/HMDB0007156/HMDB0007166/HMDB0007170/HMDB0007223/HMDB0007224/HMDB0007248/HMDB0007257/HMDB0007398HMDB0008057HMDB0007179HMDB0000564/HMDB0007878/HMDB0007879/HMDB0007880/HMDB0007882/HMDB0007884/HMDB0007886/HMDB0007887/HMDB0007897/HMDB0007898/HMDB0007911/HMDB0007912/HMDB0007913/HMDB0007914/HMDB0007936/HMDB0007937/HMDB0007938/HMDB0007939/HMDB0007940/HMDB0007958/HMDB0007959/HMDB0007960/HMDB0007961/HMDB0007964/HMDB0007966/HMDB0007967/HMDB0007981/HMDB0007982/HMDB0007983/HMDB0007984/HMDB0007985/HMDB0008002/HMDB0008003/HMDB0008004/HMDB0008005/HMDB0008028/HMDB0008029/HMDB0008065/HMDB0008066/HMDB0008067/HMDB0008068/HMDB0008069/HMDB0008070/HMDB0008071/HMDB0008091/HMDB0008092/HMDB0008119/HMDB0008120/HMDB0008121/HMDB0008126/HMDB0008129/HMDB0008145/HMDB0008147/HMDB0008182/HMDB0008183/HMDB0008186/HMDB0008191/HMDB0008192/HMDB0008230/HMDB0008231/HMDB0008232/HMDB0008233/HMDB0008269/HMDB0008270/HMDB0008271/HMDB0008272/HMDB0008274/HMDB0008304/HMDB0008306/HMDB0008308/HMDB0008309/HMDB0008312/HMDB0008317/HMDB0008322/HMDB0008323/HMDB0008324/HMDB0008375/HMDB0008377/HMDB0008379/HMDB0008400/HMDB0008401/HMDB0008402/HMDB0008409/HMDB0008410/HMDB0008413/HMDB0008414/HMDB0008415/HMDB0008416/HMDB0008426/HMDB0008427/HMDB0008428/HMDB0008429/HMDB0008431/HMDB0008444/HMDB0008507/HMDB0008508/HMDB0008509/HMDB0008510/HMDB0008514/HMDB0008515/HMDB0008516/HMDB0008522/HMDB0008536/HMDB0008537/HMDB0008538/HMDB0008539/HMDB0008540/HMDB0008541/HMDB0008542/HMDB0008543/HMDB0008606/HMDB0008607/HMDB0008608/HMDB0008609/HMDB0008610/HMDB0008611/HMDB0008612/HMDB0008614/HMDB0008615/HMDB0008655/HMDB0008657/HMDB0008658/HMDB0008659/HMDB0008660/HMDB0008661/HMDB0008662/HMDB0008663/HMDB0008664/HMDB0008665/HMDB0008668/HMDB0008669/HMDB0008670/HMDB0008671/HMDB0008672/HMDB0008673/HMDB0008674/HMDB0008676/HMDB0008681/HMDB0008682/HMDB0008683/HMDB0008684/HMDB0008686/HMDB0008688/HMDB0008690/HMDB0008691/HMDB0008692/HMDB0008697/HMDB0008698/HMDB0008699/HMDB0008700/HMDB0008702/HMDB0008703/HMDB0008704/HMDB0008706/HMDB0008707/HMDB0008730/HMDB0008731/HMDB0008732/HMDB0008733/HMDB0008734/HMDB0008735/HMDB0008736/HMDB0008737/HMDB0008738/HMDB0008745/HMDB0008746/HMDB0008747/HMDB0008748/HMDB0008749/HMDB0008750/HMDB0008751/HMDB0008752/HMDB0008754/HMDB0008758/HMDB0008761/HMDB0008762/HMDB0008766/HMDB0008768/HMDB0008770/HMDB0008773/HMDB0008774/HMDB0008775/HMDB0008791/HMDB0008792/HMDB0008793/HMDB0008795/HMDB0008796/HMDB0008798/HMDB0008799/HMDB0008800HMDB0010384HMDB0008206HMDB0008443HMDB0008748HMDB0008308HMDB0062690HMDB0009837HMDB0009059HMDB0010564HMDB0008002HMDB0002322HMDB0000015HMDB0013633HMDB0012535HMDB0001065HMDB0004666HMDB0008946HMDB0008928HMDB0011538HMDB0007972HMDB0011533HMDB0010715HMDB0011749HMDB0034158HMDB0000014HMDB0001476HMDB0062735HMDB0000440HMDB0000479HMDB0032616HMDB0000031HMDB0003681HMDB0003193HMDB0013856HMDB0003355HMDB0005081HMDB0004095HMDB0000982HMDB0002894HMDB0001170HMDB0000895HMDB0006552HMDB0000161HMDB0000517HMDB0036656HMDB0033850HMDB0013609HMDB0000043HMDB0040270HMDB0015328HMDB0000062HMDB0015267HMDB0000518HMDB0000097HMDB0014965HMDB0002068HMDB0060460HMDB0002802HMDB0000064HMDB0000562HMDB0038122HMDB0031404HMDB0015122HMDB0000630HMDB0035030HMDB0001254HMDB0000169HMDB0015068HMDB0011740HMDB0060254HMDB0003312HMDB0014832HMDB0014524HMDB0014668HMDB0033244HMDB0004437HMDB0004983HMDB0000092HMDB0000162HMDB0000158HMDB0014789HMDB0041886HMDB0000153HMDB0005030HMDB0014326HMDB0014642HMDB0003464HMDB0014367HMDB0028791HMDB0004207HMDB0000086HMDB0000637HMDB0000138HMDB0000756HMDB0000859HMDB0000870HMDB0002024HMDB0060484HMDB0015197HMDB0015352HMDB0000684HMDB0000194HMDB0062496HMDB0000641HMDB0000177HMDB0000670HMDB0000687HMDB0000182HMDB0001645HMDB0000222HMDB0000159HMDB0000070/HMDB0000716HMDB0062514HMDB0000267/HMDB0000805/HMDB0060262HMDB0062698HMDB0000187/HMDB0062263HMDB0000167HMDB0000929HMDB0002250HMDB0006469HMDB0006566HMDB0015113HMDB0004999HMDB0015539HMDB0001296HMDB0035698HMDB0001389HMDB0014597HMDB0005066HMDB0010699HMDB0001348HMDB0001238HMDB0001138HMDB0011758HMDB0001004HMDB0011759HMDB0012107HMDB0012101HMDB0002088HMDB0004949HMDB0011761HMDB0004953HMDB0005923HMDB0001406HMDB0094680HMDB0000791HMDB0002117HMDB0005065HMDB0012273HMDB0061712HMDB0000210HMDB0015245HMDB0000564HMDB0002545/HMDB0003402HMDB0015557HMDB0006236HMDB0000253HMDB0006695HMDB0000269HMDB0000648HMDB0001173HMDB0039526HMDB0000259HMDB0033696HMDB0034544HMDB0001348/HMDB0010168/HMDB0010169/HMDB0011698/HMDB0011699/HMDB0012084/HMDB0012085/HMDB0012087/HMDB0012088/HMDB0012089/HMDB0012090/HMDB0012091/HMDB0012092/HMDB0012093/HMDB0012094/HMDB0012095/HMDB0012096/HMDB0012100/HMDB0012101/HMDB0012102/HMDB0012103/HMDB0012104/HMDB0012105/HMDB0012107/HMDB0013461/HMDB0013462/HMDB0013463/HMDB0013464/HMDB0013465/HMDB0013466/HMDB0013467/HMDB0013468/HMDB0013469HMDB0000252HMDB0004827HMDB0000848HMDB0000258HMDB0015002HMDB0014958HMDB0000896HMDB0000874HMDB0094708HMDB0000875HMDB0014583HMDB0000925HMDB0000306HMDB0003073HMDB0002780HMDB0005780HMDB0011460HMDB0002183HMDB0011506HMDB0007982HMDB0010313HMDB0011130HMDB0008039HMDB0008994HMDB0008031HMDB0002107HMDB0007865HMDB0012378HMDB0002712HMDB0006294HMDB0002302HMDB0000510HMDB0002261HMDB0030524HMDB0000354HMDB0000225HMDB0001931HMDB0003224HMDB0001409HMDB0005998HMDB0004026HMDB0000375HMDB0001032HMDB0002203HMDB0000428HMDB0000754HMDB0000732HMDB0001954HMDB0003332HMDB0000459HMDB0000423HMDB0062295HMDB0000500HMDB0060530HMDB0000543HMDB0000017HMDB0006248HMDB0062657HMDB0060661HMDB0000060HMDB0006254HMDB0000462HMDB0000019HMDB0001893HMDB0002829HMDB0030837HMDB0002212HMDB0001043HMDB0000191HMDB0005006HMDB0001870HMDB0000011HMDB0003134HMDB0000511HMDB0000653HMDB0000619HMDB0030282HMDB0011621HMDB0003229HMDB0000072HMDB0006331HMDB0141782HMDB0001547HMDB0002269HMDB0031340HMDB0000731HMDB0000089HMDB0062473HMDB0000539HMDB0006483HMDB0000277HMDB0000639HMDB0000625HMDB0001109HMDB0000765HMDB0003848HMDB0003411HMDB0000283HMDB0003418HMDB0000626HMDB0001227HMDB0131138HMDB0000079HMDB0000076HMDB0000008HMDB0124926HMDB0030396HMDB0000623HMDB0000638HMDB0002994HMDB0004483HMDB0001425HMDB0010325HMDB0031233HMDB0015109HMDB0130571HMDB0014850HMDB0000660HMDB0005826HMDB0000565HMDB0001049HMDB0011737HMDB0003217HMDB0000152HMDB0028817HMDB0028821HMDB0028823HMDB0000148HMDB0000661HMDB0003337HMDB0031818HMDB0000126HMDB0000631HMDB0013222HMDB0000128HMDB0029344HMDB0002259HMDB0000714HMDB0000884HMDB0000273HMDB0011719HMDB0000624HMDB0000755HMDB0000350HMDB0000012HMDB0000738HMDB0000734HMDB0000671HMDB0000682HMDB0000730HMDB0002923HMDB0000678HMDB0032797HMDB0000695HMDB0000715HMDB0000168HMDB0000033HMDB0000904HMDB0000174HMDB0003466HMDB0002205HMDB0004224HMDB0011632HMDB0000696HMDB0000943HMDB0000883HMDB0000673HMDB0000761HMDB0000156HMDB0011730HMDB0000048HMDB0015446HMDB0014703HMDB0135651HMDB0015335HMDB0041933HMDB0000211HMDB0000806HMDB0003357HMDB0001067HMDB0000215HMDB0001367HMDB0000766HMDB0011745HMDB0000512HMDB0000866HMDB0006029HMDB0014748HMDB0001015HMDB0033835HMDB0002368HMDB0000827HMDB0000207HMDB0000226HMDB0000788HMDB0010316HMDB0002035HMDB0000220HMDB0004231HMDB0000826HMDB0000821HMDB0000228HMDB0060014HMDB0000779HMDB0001565HMDB0000245HMDB0060382HMDB0000795HMDB0015537HMDB0002664HMDB0000767HMDB0034050HMDB0001491HMDB0000957HMDB0001167HMDB0000243HMDB0003072HMDB0003213HMDB0000508HMDB0001066HMDB0001895HMDB0000840HMDB0000271HMDB0003070HMDB0000114HMDB0003553HMDB0000254HMDB0000251HMDB0000951HMDB0000036HMDB0002580HMDB0060619HMDB0000872HMDB0000268HMDB0002666HMDB0003252HMDB0000262HMDB0000930HMDB0000300HMDB0000289HMDB0000296HMDB0000301HMDB0000044HMDB0000299HMDB0001554HMDB0014543