MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14264/m_MTBLS14264_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14264/m_MTBLS14264_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14264/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14264/s_MTBLS14264.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14264/a_MTBLS14264_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14264/a_MTBLS14264_LC-MS_positive_reverse-phase.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14264<p>R4.4.1 AND Rstudio.Data analysis, boxplot and heatmap plotting using R 4.4.1 and RStudio</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phase<p>Chromatographic separation was performed on ACQUITY UPLC CSH C18 column (100 mm × 2.1 mm; particles: 1.7 μm; Waters Corporation, Millford, MA, USA) with precolumn (5 mm × 2.1 mm; 1.7 μm particles). The column temperature was 65 °C and the flow rate 0.4 mL/min. Mobile phase A was composed of H2O/ACN 2:3 (v/v) containing 10 mM ammonium formate and 0.1% formic acid (v/v) while mobile phase B was IPA/ACN/H2O 90:9:1 (v/v/v) containing 10 mM ammonium formate and 0.1% FA (v/v). The gradient elution started from 15% B to 30% B in 4 min, followed by increase of B to 48% in 1 min. Then mobile phase B was further increased to 82% at 22 min and quickly reached 99% in the next 3 min followed by holding this percentage for another 1 min. Afterwards, the percentage of B was back to starting conditions (15% B) in 0.1 min to re-equilibrate the column for the next injection (3.9 min).</p><p><br></p><p>&nbsp;arrow_drop_uphide</p>Pentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia/reperfusion injury in the heart.shanghai universityYUXUAN ZHANGmyocardiummass spectrometry assay<p>For lipid extraction, heart tissues were homogenized on ice in pre-cooled phosphate-buffered saline (PBS). Briefly, 10 mg heart tissue was mixed with 100 µL PBS in 2 mL EP tubes containing ceramic beads. Samples were homogenized by cryogrinder at 4 °C (70 Hz, 2 cycles of 30 s with 15 s interval) to obtain uniform suspensions. All solvents, including methanol (MeOH), methyl tert-butyl ether (MTBE), isopropanol (IPA), and water, were pre-cooled to 4 °C. An internal standard mixture was prepared using EquiSPLASH LIPIDOMIX Quantitative Internal Standard from Sigma-Aldrich(Darmstadt, Germany) and diluted to a working concentration of 500 ng/mL in methanol.</p><p><br></p><p>For monophasic MMIPA extraction (MeOH:MTBE:IPA = 1.33:1:1), 50 µL of tissue homogenate (equivalent to 5 mg tissue) was transferred into a 1.5 mL EP tube and centrifuged at 20,500 × g for 10 min at 4 °C. After removal of the PBS layer to prevent salt contamination, 50 µL of internal standard solution was added, followed by 350 µL MeOH, 300 µL MTBE, and 300 µL IPA. The mixture was vortexed for 30 s, sonicated for 2 min, and incubated on ice for 1 h, followed by an additional 2 min sonication. After centrifugation (20,500 × g, 10 min, 4 °C) by microcentrifuge from Thermo Fisher Scientific (Massachusetts, USA), the supernatant containing the lipid extract was collected and dried in the centrivap cold trap under nitrogen protection at 4 °C. The residue was reconstituted in 50 µL methanol, vortexed for 10 s, sonicated for 2 min, and centrifuged again before transfer of the supernatant into HPLC vials for LC–MS/MS analysis.</p><p><br></p><p>All sample preparation steps were performed under light protection. A pooled quality control (QC) sample was prepared by mixing 10 μL aliquots of each reconstituted samples.</p>Mus musculushttps://www.ebi.ac.uk/metabolights/MTBLS14264Yuxuan Zhang. Shanghai University. 19857430904@shu.edu.cn.Qingxun Hu. Shanghai University. qingxh@shu.edu.cn.<p>Analytics data platform , including metaboanalyst, along with freely available MS-DIAL ver4.60, were used for data processing.Data processing involved the use of MS-DIAL for peak finding, Lipid Blast database search, normalization to internal standards and LOWESS, and identification through spectral matching. Metaboanalyst platform was utilized for logarithmic transformation (base 10) and autoscaling.</p>Sports19857430904@shu.edu.cn<p>Extract myocardial tissue from C57BL6J mice after four weeks of swimming</p>MetabolomicsNADPHpooled quality control sampleG6PDMus musculusischemia/reperfusion injurycardiomyocyte growthuntargeted analysisexerciseLipidomicsmyocardiumThermo Scientific Q Exactive Plusexperimental sampleThermo Scientific Dionex UltiMate 3000 SystemNADPHpooled quality control sampleG6PDMus musculusischemia/reperfusion injurycardiomyocyte growthuntargeted analysisexerciseLipidomicsmyocardiumThermo Scientific Q Exactive Plusexperimental sampleThermo Scientific Dionex UltiMate 3000 System<p>The mass spectrometer operated in ESI positive mode with specific parameters. An MS full scan experiment with mass range m/z 85-1250 was selected while different SWATH windows were acquired for MS/MS experiments. The Capillary temperature was set to 320°C with sheath gas and aux gas, respectively, for both modes. The ion spray voltage was set to 3500 V in the positive mode and -3200 V in negative mode. The cycle time was always 650 ms.&nbsp;&nbsp;</p>SM 40:1;2ODG 36:4|DG 18:2_18:2PC 42:10PE 36:1|PE 18:0_18:1DG O-30:1|DG O-16:0_14:1Cer 47:3;3O|Cer 18:2;2O/29:1;OPC 31:0DG 44:9|DG 22:4_22:5TG 58:2;2O|TG 21:0_21:2_16:0;2ODG O-31:1|DG O-15:0_16:1TG 54:4|TG 18:1_18:1_18:2DG 37:2|DG 19:0_18:2TG 53:4|TG 17:0_17:1_19:3PC O-32:1PC 54:5|PC 16:0_38:5Cer 44:4;3O|Cer 18:1;2O/26:3;OPC O-32:0PC O-32:2TG 62:5|TG 20:0_20:2_22:3PE 38:5SM 39:1;2OPE 38:3SM 34:8;2OSM 35:2;2O|SM 18:1;2O/17:1PE 38:6TG 46:3|TG 10:0_18:1_18:2TG 47:0|TG 15:0_16:0_16:0Cer 33:1;2O|Cer 17:1;2O/16:0TG 47:1|TG 15:0_16:0_16:1PC O-44:8PI 37:4PC O-44:5DG O-37:1|DG O-21:0_16:1PC O-44:6TG 53:2|TG 17:0_17:1_19:1PE P-35:2|PE P-17:0_18:2SM 40:0;3OPE P-40:5|PE P-18:0_22:5PE 36:0|PE 18:0_18:0TG 40:0|TG 8:0_16:0_16:0TG 60:6|TG 18:0_18:1_24:5SM 42:2;2O|SM 18:1;2O/24:1Cer 44:3;3O|Cer 19:2;2O/25:1;OPE 36:2|PE 18:0_18:2PC 40:6|PC 18:0_22:6TG 58:10|TG 18:2_18:2_22:6PE P-38:3|PE P-20:1_18:2PG 31:5DG O-34:1|DG O-18:0_16:1PC O-33:0PC O-33:2TG 61:3|TG 22:0_17:1_22:2SM 40:0;2OTG 42:2|TG 8:0_16:0_18:2PE 37:6TG 52:6|TG 16:0_16:2_20:4TG 58:8|TG 18:1_20:2_20:5Cer 41:1;2O|Cer 18:1;2O/23:0CAR 19:1CAR 19:0TG 24:0|TG 8:0_8:0_8:0PC 42:5PC 42:6PC 42:3TG 54:4;2O|TG 18:1_18:1_18:2;2OPC 42:9PC 42:7PC 42:8TG 55:5|TG 17:0_17:1_21:4PG 43:9Cer 39:4;3O|Cer 18:2;2O/21:2;ODG 34:2|DG 16:0_18:2TG 51:3|TG 17:0_15:1_19:2PC 52:10|PC 18:4_34:6PI 38:6TG 62:11|TG 18:1_22:4_22:6PI 38:5SM 35:1;2OSM 41:2;2O|SM 18:1;2O/23:1PI 38:4PI 38:3TG 60:4|TG 22:0_18:2_20:2LPC 15:0/0:0TG 58:4|TG 18:1_22:1_18:2TG 47:3|TG 16:0_16:1_15:2TG 60:8;2O|TG 21:2_17:3_22:3;2OCer 41:2;2O|Cer 18:2;2O/23:0PE P-40:6|PE P-18:1_22:5Cer 42:3;2O|Cer 18:1;2O/24:2TG 51:3|TG 15:0_18:1_18:2TG 50:2|TG 16:0_16:1_18:1TG 62:10|TG 20:3_22:3_20:4TG 58:5|TG 18:1_18:2_22:2PE O-38:6PE P-40:6|PE P-18:0_22:6PG 32:5DG 32:0|DG 16:0_16:0Cer 32:1;2O|Cer 18:1;2O/14:0CAR 18:2TG 56:9|TG 18:2_18:3_20:4CAR 18:0SM 40:2;2O|SM 20:0;2O/20:2TG 54:2|TG 16:0_18:1_20:1PC 38:6|PC 16:0_22:6PC 41:6PE P-38:2|PE P-20:0_18:2TG 58:6|TG 18:1_18:2_22:3PC 41:7PC 41:4PC O-30:1Cer 42:2;2O|Cer 18:1;2O/24:1PC O-30:0CAR 18:3TG 48:1|TG 14:0_16:0_18:1Cer 45:2;2O|Cer 20:1;2O/25:1TG 64:7|TG 20:2_22:2_22:3TG 55:4|TG 15:0_19:0_21:4PC O-42:8PC O-42:5TG 60:12|TG 18:2_20:4_22:6PC O-42:6DG 40:5|DG 18:0_22:5Cer 46:5;3O|Cer 18:1;2O/28:4;OPC 44:12PE P-38:4|PE P-18:0_20:4LPC 20:3LPC 20:4PC 44:10DG 38:5|DG 18:1_20:4PC 51:9TG 47:0;2O|TG 16:0_16:0_15:0;2OTG 48:4|TG 12:0_18:2_18:2TG 56:4|TG 18:1_20:1_18:2TG 46:1|TG 14:0_16:0_16:1Cer 34:2;2O|Cer 18:2;2O/16:0PE P-40:7|PE P-18:1_22:6Cer 40:2;3O|Cer 18:2;2O/22:0;OTG 47:4|TG 14:0_15:2_18:2TG 62:7|TG 20:2_20:2_22:3DG O-29:1|DG O-15:0_14:1PC 40:3CAR 17:2PC 40:1CAR 17:1PC 40:2PC 40:7PE 39:7PC 40:8PC O-31:0PE 39:6TG 49:3|TG 15:0_16:1_18:2TG 60:3;2O|TG 21:1_21:1_18:1;2OPC 40:5SM 38:0;2OPC 40:9Cer 44:1;2O|Cer 18:1;2O/26:0TG 58:9|TG 18:1_18:2_22:6DG 34:1|DG 16:0_18:1TG 54:2;3O|TG 18:1_18:1_18:0;3OPE 34:3|PE 16:1_18:2PI 36:3LPE O-22:2PI 36:2TG 60:11|TG 18:2_20:3_22:6TG 61:4|TG 19:0_20:2_22:2PC 50:9TG 48:0|TG 16:0_16:0_16:0SM 37:2;2O|SM 19:0;2O/18:2TG 54:6|TG 18:2_18:2_18:2TG 58:2|TG 16:0_18:1_24:1TG 59:3|TG 20:0_20:1_19:2PC O-36:5LPE 20:1PC O-36:4PC O-36:6SM 42:4;3OLPE O-18:1LPE O-18:2DG 40:2|DG 18:1_22:1SM 34:0;3OTG 43:2|TG 9:0_16:0_18:2TG 55:3|TG 19:0_18:1_18:2LPC 18:2PC O-36:1PC O-36:0PC O-36:2CAR 16:2CAR 16:1TG 60:3|TG 18:1_20:1_22:1LPC 18:0PE P-36:4|PE P-18:2_18:2TG 59:9|TG 19:2_19:2_21:5PE P-38:6|PE P-16:0_22:6TG 51:5|TG 17:0_17:1_17:4TG 56:7|TG 16:0_18:2_22:5SM 36:1;2OCer 28:1;4O|Cer 15:1;3O/13:0;(2OH)Cer 40:1;2O|Cer 18:1;2O/22:0TG 53:4|TG 17:1_18:1_18:2PE 34:2|PE 16:0_18:2DG 44:3|DG 26:1_18:2SM 34:0;2OPE 36:4|PE 18:2_18:2PE O-40:9SM 40:4;3OTG 51:1|TG 15:0_17:0_19:1TG 44:2|TG 10:0_16:0_18:2TG 52:4;2O|TG 17:0_17:1_18:3;2OPE O-40:6TG 56:8|TG 16:0_18:2_22:6Cer 37:2;2O|Cer 18:2;2O/19:0DG 41:7|DG 19:1_22:6PS 42:1Cer 39:3;3O|Cer 18:2;2O/21:1;ODG 44:12|DG 22:6_22:6CAR 26:1CAR 26:0TG 58:11|TG 18:2_18:3_22:6PC O-37:6LPE O-17:1DG 32:1|DG 18:0_14:1PC O-37:7LPC 19:4SE 29:1/18:5SM 34:2;2O|SM 18:2;2O/16:0SM 34:1;2O|SM 18:1;2O/16:0TG 55:4|TG 17:0_19:2_19:2DG 32:2|DG 16:1_16:1TG 54:7|TG 18:2_18:2_18:3TG 57:2|TG 15:0_17:1_25:1TG 62:9|TG 20:1_20:3_22:5TG 50:3;2O|TG 16:0_16:0_18:3;2ODG O-35:1|DG O-19:1_16:0Cer 42:3;3O|Cer 18:2;2O/24:1;OCAR 15:1CAR 15:0SM 36:0;3OCer 48:3;3O|Cer 20:1;2O/28:2;OCer 45:3;3O|Cer 17:1;2O/28:2;OTG 53:1|TG 16:0_20:0_17:1Cer 44:5;3O|Cer 18:2;2O/26:3;OTG 64:4|TG 20:0_20:0_24:4TG 49:0|TG 15:0_16:0_18:0LPC O-22:3LPC 20:2/0:0PC 46:8|PC 20:4_26:4TG 49:1|TG 15:0_16:0_18:1DG 38:2|DG 18:1_20:1Cer 36:2;3O|Cer 18:0;2O/18:2;OTG 62:14|TG 18:2_22:6_22:6PE 40:8TG 58:1|TG 14:0_18:0_26:1PE 40:5TG 64:5|TG 20:0_20:0_24:5CAR 25:0PE 40:6Cer 41:4;3O|Cer 21:0;2O/20:4;OSM 42:3;2OLPE O-16:1Cer 34:0;2O|Cer 18:0;2O/16:0SM 45:1;2O|SM 18:1;2O/27:0DG 34:4|DG 16:2_18:2TG 50:3|TG 16:0_16:1_18:2TG 53:5|TG 17:0_15:1_21:4PC O-34:1SM 36:0;2O|SM 18:0;2O/18:0PC O-34:0PC O-34:3PC O-34:2SM 42:0;2O|SM 18:0;2O/24:0Cer 38:3;3O|Cer 18:1;2O/20:2;OPC O-34:4SM 44:1;2OPC 32:0|PC 16:0_16:0TG 52:2|TG 16:0_18:0_18:2TG 64:16|TG 20:4_22:6_22:6BMP 40:8|BMP 18:2_22:6TG 48:2|TG 14:0_16:0_18:2PE 34:0|PE 16:0_18:0Cer 40:1;3O|Cer 18:1;2O/22:0;OTG 45:2|TG 15:0_14:1_16:1PE P-38:5|PE P-16:0_22:5TG 50:0|TG 16:0_16:0_18:0PS 40:1Cer 32:3;3O|Cer 15:1;2O/17:2;ODG O-35:1|DG O-17:0_18:1CAR 24:5DG 40:4|DG 20:1_20:3DG 42:3|DG 24:1_18:2PS 40:6HexCer 42:1;2O|HexCer 18:1;2O/24:0DG 36:5|DG 18:2_18:3DG O-27:1|DG O-13:0_14:1Cer 36:1;2O|Cer 18:1;2O/18:0LPC 22:4/0:0Cer 46:1;2O|Cer 20:1;2O/26:0PE P-36:2|PE P-18:0_18:2CAR 24:1TG 61:2|TG 18:0_17:1_26:1CAR 24:0PE 35:1|PE 17:0_18:1PE P-36:4|PE P-16:0_20:4DG 38:7|DG 16:1_22:6PC 58:12TG 44:3|TG 8:0_18:1_18:2PC O-35:4TG 56:5|TG 18:0_18:2_20:3TG 44:0|TG 14:0_14:0_16:0TG 51:2|TG 17:0_16:1_18:1TG 56:1|TG 16:0_22:0_18:1Cer 26:1;3O|Cer 15:1;2O/11:0;OPG 41:9LPC O-20:0Cer 37:3;3O|Cer 18:2;2O/19:1;OCer 44:0;2O|Cer 20:0;2O/24:0Cer 42:2;2O|Cer 18:2;2O/24:0TG 54:0|TG 16:0_18:0_20:0PE P-40:3|PE P-22:1_18:2TG 46:4|TG 12:0_16:1_18:3ST 27:1;OCer 39:1;2O|Cer 18:1;2O/21:0Cer 43:2;3O|Cer 18:1;2O/25:1;OPC 39:1CAR 23:0TG 57:3|TG 18:1_19:1_20:1TG 58:3|TG 16:0_22:0_20:3DG 40:6|DG 18:1_22:5PC 39:5TG 53:0|TG 17:0_18:0_18:0PC 39:6PC 39:4PC 39:7SPB 18:1;2OPE 38:7|PE 16:1_22:6SM 37:1;2OSL 33:0;2O|SL 17:0;O/16:0;OPI 40:6LPC 14:0PI 40:5TG 57:7|TG 17:0_19:3_21:4TG 54:1|TG 16:0_20:0_18:1TG 54:3|TG 18:0_18:1_18:2MG 18:3TG 58:6;3O|TG 19:2_19:2_20:2;3OPC 28:0PC 28:4Cer 43:4;3O|Cer 19:0;2O/24:4;OTG 54:4;2O|TG 17:0_17:3_20:1;2OPG 44:10DG 38:7|DG 18:2_20:5TG 54:0;2O|TG 17:0_17:0_20:0;2OTG 51:4|TG 13:0_17:0_21:4PE 41:6PC 38:2CAR 22:1PC 38:3CAR 22:0TG 68:5|TG 16:1_32:1_20:3DG 40:5|DG 18:1_22:4HexCer 40:1;2O|HexCer 18:1;2O/22:0PC 38:1SPB 18:0;2ODG 40:7|DG 18:1_22:6PC 38:4CAR 22:3DG 38:1|DG 20:0_18:1PC 38:5CAR 22:2DG 42:1|DG 24:0_18:1Cer 38:2;3O|Cer 18:2;2O/20:0;OSM 42:1;2OSM 31:4;3OLPC 20:0/0:0PI 42:8ST 27:2;OCer 36:2;2O|Cer 18:2;2O/18:0SM 41:2;2O|SM 22:0;2O/19:2SM 32:1;2O|SM 18:1;2O/14:0DG O-33:1|DG O-15:1_18:0TG 58:0;2O|TG 18:0_21:0_19:0;2OTG 56:6|TG 16:0_18:1_22:5PE 40:1DG 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19:0/0:0LPC 24:0/0:0LPE 16:0TG 46:2|TG 12:0_16:0_18:2LPE 16:1falsePentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia/reperfusion injury in the heart<p>Exercise promotes physiological cardiomyocyte growth and protects against ischemia/reperfusion (I/R) injury in the heart. The molecular mechanism by which exercise benefits cardiac metabolism and function remains largely unknown. Using a genetically encoded fluorescent indicator, we found that exercise increased cytosolic, but not mitochondrial, NADPH levels in cardiomyocytes. This effect was mediated by activation of pentose phosphate pathway (PPP). Downregulation of G6PD expression through knocking down transcription factor SP1 or G6PD itself, or depletion of cytosolic NADPH blocked exercise-induced heart hypertrophy. NADPH promoted cardiomyocyte growth through inhibiting HDAC3/C/EBPβ pathways. Moreover, exercise suppressed acute I/R injury and preserved heart function 4 weeks after I/R by mediating G6PD/NADPH pathway. Among 310 Tibetan compounds, lyciumspermidine-0527, a new spermidine derivative, directly activated G6PD, elevated intracellular NADPH levels, promoted cardiomyocytes growth and alleviated I/R injury. PPP-derived NADPH is a critical metabolic checkpoint that regulates exercise-induced physiological cardiomyocyte growth and protects against I/R-induced heart injury.</p>2026-04-132026-04-13MTBLS14264Cer 33:1;2O|Cer 17:1;2O/16:0Cer 34:0;2O|Cer 18:0;2O/16:0Cer 34:1;2O|Cer 18:1;2O/16:0Cer 34:2;2O|Cer 18:2;2O/16:0Cer 35:1;2O|Cer 17:1;2O/18:0Cer 36:1;2O|Cer 18:1;2O/18:0Cer 36:2;2O|Cer 18:2;2O/18:0Cer 37:1;2O|Cer 17:1;2O/20:0Cer 37:2;2O|Cer 18:2;2O/19:0Cer 38:1;2O|Cer 18:1;2O/20:0Cer 38:2;2O|Cer 18:2;2O/20:0Cer 39:1;2O|Cer 18:1;2O/21:0Cer 39:2;2O|Cer 18:2;2O/21:0Cer 40:0;2O|Cer 18:0;2O/22:0Cer 40:1;2O|Cer 18:1;2O/22:0Cer 40:2;2O|Cer 18:2;2O/22:0Cer 40:2;4O|Cer 23:1;3O/17:1;(2OH)Cer 41:1;2O|Cer 18:1;2O/23:0Cer 41:2;2O|Cer 18:2;2O/23:0Cer 41:2;2O|Cer 20:2;2O/21:0Cer 42:1;2O|Cer 18:1;2O/24:0Cer 42:2;2O|Cer 18:1;2O/24:1Cer 42:2;2O|Cer 18:2;2O/24:0Cer 42:3;2O|Cer 18:2;2O/24:1Cer 43:2;2O|Cer 18:2;2O/25:0CAR 15:0CAR 15:1CAR 16:1CAR 16:2CAR 17:1CAR 17:2CAR 18:0CAR 18:2CAR 18:3CAR 19:0CAR 19:1CAR 20:0CAR 20:1CAR 20:2CAR 20:3CAR 21:0CAR 22:0CAR 22:1CAR 22:2CAR 22:3CAR 23:0CAR 24:0CAR 24:1CAR 24:5CAR 25:0CAR 26:0CAR 26:1Cer 26:1;3O|Cer 15:1;2O/11:0;OCer 28:1;4O|Cer 15:1;3O/13:0;(2OH)Cer 32:1;2O|Cer 18:1;2O/14:0Cer 32:3;3O|Cer 15:1;2O/17:2;OCer 35:3;3O|Cer 18:2;2O/17:1;OCer 36:2;3O|Cer 18:0;2O/18:2;OCer 37:1;2O|Cer 18:1;2O/19:0Cer 37:3;3O|Cer 18:2;2O/19:1;OCer 38:2;3O|Cer 18:2;2O/20:0;OCer 38:3;3O|Cer 18:1;2O/20:2;OCer 38:3;3O|Cer 20:0;2O/18:3;OCer 38:4;3O|Cer 18:1;2O/20:3;OCer 39:1;3O|Cer 18:1;2O/21:0;OCer 39:3;3O|Cer 18:2;2O/21:1;OCer 39:4;3O|Cer 18:2;2O/21:2;OCer 40:1;3O|Cer 18:1;2O/22:0;OCer 40:2;3O|Cer 17:1;2O/23:1;OCer 40:2;3O|Cer 18:2;2O/22:0;OCer 40:4;3O|Cer 18:2;2O/22:2;OCer 41:4;3O|Cer 17:1;2O/24:3;OCer 41:4;3O|Cer 21:0;2O/20:4;OCer 42:0;2O|Cer 18:0;2O/24:0Cer 42:3;2O|Cer 18:1;2O/24:2Cer 42:3;3O|Cer 18:2;2O/24:1;OCer 42:4;3O|Cer 18:2;2O/24:2;OCer 43:1;2O|Cer 18:1;2O/25:0Cer 43:1;3O|Cer 18:1;2O/25:0;OCer 43:2;3O|Cer 18:1;2O/25:1;OCer 43:4;3O|Cer 19:0;2O/24:4;OCer 44:0;2O|Cer 20:0;2O/24:0Cer 44:1;2O|Cer 18:1;2O/26:0Cer 44:2;3O|Cer 18:0;2O/26:2;OCer 44:3;3O|Cer 18:1;2O/26:2;OCer 44:3;3O|Cer 19:2;2O/25:1;OCer 44:4;3O|Cer 18:1;2O/26:3;OCer 44:5;3O|Cer 18:2;2O/26:3;OCer 45:0;2O|Cer 20:0;2O/25:0Cer 45:2;2O|Cer 20:1;2O/25:1Cer 45:2;3O|Cer 18:1;2O/27:1;OCer 45:3;3O|Cer 17:1;2O/28:2;OCer 46:1;2O|Cer 20:1;2O/26:0Cer 46:3;3O|Cer 20:1;2O/26:2;OCer 46:5;3O|Cer 18:1;2O/28:4;OCer 46:6;4OCer 47:3;3O|Cer 18:2;2O/29:1;OCer 48:3;3O|Cer 20:1;2O/28:2;O