MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14280/m_MTBLS14280_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14280/m_MTBLS14280_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14280/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14280/s_MTBLS14280.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14280/a_MTBLS14280_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14280/a_MTBLS14280_LC-MS_positive_reverse-phase.txtprimary200OKftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14280<p>Metabolite annotation was performed using Progenesis QI (version 3.0) by matching detected features against METLIN, KEGG, HMDB, LIPID MAPS, and an in-house spectral library. Precursor and fragment mass tolerances were set to 100 ppm and 50 ppm, respectively. Only features supported by acceptable isotopic and fragment evidence and showing acceptable QC performance were retained. Annotated metabolites were subsequently used for downstream interpretation, including focused reporting of hormone-related metabolites relevant to the study.</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phase<p>Chromatographic separation was performed using a Waters ACQUITY UPLC I-Class PLUS system equipped with an ACQUITY UPLC HSS T3 column (1.8 um, 2.1 x 100 mm, Waters). The injection volume was 1 uL and the flow rate was 0.4 mL min-1. The mobile phases consisted of 0.1% formic acid in water (A) and 0.1% formic acid in acetonitrile (B). The assay was conducted under reverse-phase LC conditions. Positive- and negative-ion datasets were acquired as separate assays using the same chromatographic platform and column configuration.</p>Endocrine remodeling during musk secretion is associated with diet-linked gut microbiome shifts in forest musk deer (Moschus berezovskii): a paired within-individual study.Beijing Forestry UniversityPengcheng Yangblood serummass spectrometry assay<p>For metabolite extraction, 100 uL of serum was mixed with 500 uL of cold methanol:acetonitrile (1:1, v/v) containing 2-chloro-L-phenylalanine (20 mg L-1) as an internal standard. The mixture was vortexed for 30 s, sonicated on ice for 10 min, incubated at -20 C for 1 h for protein precipitation, and centrifuged at approximately 9,600 x g for 15 min at 4 C. A total of 500 uL of supernatant was vacuum-dried and reconstituted in 160 uL acetonitrile:water (1:1, v/v). The reconstituted extract was vortexed and sonicated again, cleared by centrifugation, and 120 uL was transferred to LC-MS vials for analysis. Pooled QC samples were prepared by mixing 10 uL aliquots from each serum sample and were injected regularly throughout the analytical run.</p>Moschus berezovskiihttps://www.ebi.ac.uk/metabolights/MTBLS14280Pengcheng Yang. Beijing Forestry University. Beijing Forestry University, No. 35 Qinghua East Road, Haidian District, Beijing,100083,China. yxsdyx18@bjfu.edu.cn.<p>Raw LC-MS data were processed in Progenesis QI (version 3.0) for peak detection, retention-time alignment, and signal normalization. Positive- and negative-ion datasets were processed separately. Quality-control performance was assessed during the analytical workflow, and only features with acceptable QC behavior were retained for downstream analysis. The resulting feature tables were used for metabolite annotation and statistical analysis.</p>Stageyxsdyx18@bjfu.edu.cn<p>Paired serum samples were collected from captive adult male forest musk deer (Moschus berezovskii) at two physiological stages: pre-secretion and secretion. Animals were maintained at the Zhiyang Tianbao Forest Musk Deer Artificial Breeding Base under comparable husbandry conditions. Blood samples were collected by a licensed veterinarian under gentle physical restraint without anesthesia. Approximately 5 mL of blood was drawn from the lateral saphenous vein after skin disinfection with 70% ethanol and collected into plain tubes. Samples were kept on ice and centrifuged at 600 x g for 10 min at 4 C. Serum was aliquoted into sterile cryovials and stored at -80 C until metabolomics analysis. Serum samples were thawed once before extraction. Pooled quality-control (QC) samples were prepared separately for LC-MS analysis.</p>MetabolomicsLC-MS dataMetabolomicsMoschus berezovskiiWaters ACQUITY UPLC I-Class PLUS SystemWaters Xevo G2-XS QTofuntargeted analysisblood serumquality control sampleProgenesis QIuntargeted metabolite profilingexperimental sampleLC-MS dataMetabolomicsMoschus berezovskiiWaters ACQUITY UPLC I-Class PLUS SystemWaters Xevo G2-XS QTofuntargeted analysisblood serumquality control sampleProgenesis QIuntargeted metabolite profilingexperimental sample<p>Mass spectrometry data for the positive-ion assay were acquired on a Waters Xevo G2-XS QTOF mass spectrometer equipped with an electrospray ionization source operating in positive ion mode. Data were collected using MSe acquisition with a low collision energy of 2 V and a high collision energy ramp of 10-40 V. Spectra were acquired over an m/z range of 50-1200 with an acquisition time of 0.2 s per spectrum. The mass analyzer was quadrupole time-of-flight.</p><p>Mass spectrometry data for the negative-ion assay were acquired on a Waters Xevo G2-XS QTOF mass spectrometer equipped with an electrospray ionization source operating in negative ion mode. Data were collected using MSe acquisition with a low collision energy of 2 V and a high collision energy ramp of 10-40 V. Spectra were acquired over an m/z range of 50-1200 with an acquisition time of 0.2 s per spectrum. The mass analyzer was quadrupole time-of-flight.</p>LysoPC(20:3(8Z,11Z,14Z)/0:0)3-dimethylsulfoniopropionaldehydeProstaglandin G23,3-Dimethylglutaric acidPyrocatechol3H-DopamineMG(0:0/18:1(11Z)/0:0)DeoxyinosineEctoine(S)-[10]-GingerolCladinosePS(20:2(11Z,14Z)/18:0)1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acidLamivudine-monophosphatePropyl 1-(propylsulfinyl)propyl disulfidePantothenolLysoPE(0:0/18:1(11Z))L-ErythruloseL-Histidine16-a-Hydroxypregnenolone3,7-Dimethyl-1-propargylxanthineMethylphosphonateSM(d18:1/16:1(9Z))TyrosylhydroxyprolineThymoquinone3beta-Hydroxypregn-5-en-20-one sulfateOxoglutaric acid2,3-Dinor-TXB2(±)-2-Hydroxy-2-phenylacetonitrilePIP(22:4(10Z,13Z,16Z,19Z)/PGJ2)Norepinephrine sulfate(2S,4S)-MonatinAlloxanTropoloneD-Glucuronic acid3-(2-Hydroxyphenyl)propionic acidS-Nitrosohomocysteine2-Amino-5-phosphonopentanoic acidMethylimidazole acetaldehydeDihydroergotamineGanglioside GA2 (d18:1/9Z-18:1)Benzyl alcohol, 4-(2,4-diamino-5-pyrimidinylmethyl)-2,6-dimethoxy-alpha,alpha-dimethyl-PS(18:0/20:3(6,8,11)-OH(5))(6beta,8betaOH)-6,8-Dihydroxy-7(11)-eremophilen-12,8-olide4-HydroxybenzaldehydeLysoPC(O-18:0/0:0)5-Nitro-2-(3-phenylpropylamino)benzoic acid(1R,2S)-Naphthalene 1,2-oxideProstaglandin E1LysoPE(P-16:0/0:0)3-O-Sulfogalactosylceramide (d18:1/20:0)Furo[3,2-c]pyran-4-one4,5-Dihydro-4-((1-piperazinyl)acetyl)-7-(3-(trifluoromethyl)phenyl)pyrazolo(1,5-a)pyrimidine-3-carbonitrile4-(4-Hydroxyphenyl)-2-butanone glucoside2-MethoxyestroneMolindoneLysoPC(P-16:0/0:0)4-Hydroxycinnamyl aldehydeL-Olivosyl-oleandolideMevalonolactoneLysoPA(P-16:0/0:0)Boldione1-MonopalmitinGlyceryl methylmethacrylateLysoPC(14:0/0:0)Sudachiin BLysoPE(0:0/18:2(9Z,12Z))Proline betaineHydralazineLidocaine(±)-3-Hydroxynonanoic acid2-Oxo-4-methylthiobutanoic acid16b-HydroxyestroneDifluorodeoxycytidine2',3'-Dideoxycytidine-5'-monophosphate2-Propylglutaric acid5-HydroxyindoleacetylglycineTrimethoprim3alpha,7alpha-Dihydroxy-5beta-cholestaneBenzotrifluorideDelta-12-Prostaglandin J2PC(15:0/20:1(11Z))Tetrahydrofolyl-[Glu](2)Deoxycholic acid glycine conjugateNeopetasitenineImidazotetrazinePC(20:0/PGF2alpha)Octanal3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-oneKetotifenDihydro-3-coumaric acidButanoic acid, 2,3-dihydroxypropyl ester2',3'-Cyclic GMPFusidic AcidBuspironeSibrafibanSolketal21-HydroxypregnenoloneCotinine glucuronide2-[[[4-(3-Benzylcyclobutyl)-1,3-thiazol-2-yl]diazenyl]methyl]phenol3-Furoic acid(1R*,2R*,4R*,8S*)-p-Menthane-1,2,8,9-tetrol 9-glucosideDeoxyribose 5-phosphate5-Methoxytryptamine6''-O-Malonylglycitin3-O-Sulfogalactosylceramide (d18:1/22:0)2-(3-Methylpiperidin-1-yl)[1,3]thiazolo[4,5-d]pyrimidin-7(6H)-one(Z)-11-Eicosen-1-ol2,4-Quinolinediol1-(9Z-hexadecenoyl)-glycero-3-phosphateMethyl (E)-2-dodecenoateGalabiosylceramide (d18:1/25:0)Methyl N-[6-[(4-pyridin-2-ylpiperazine-1-carbonyl)amino]-1H-benzimidazol-2-yl]carbamateGuanosine-3',5'-Diphosphate(1R,4Ar,5S,7R)-7-methyl-1-[(2R,3S,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-4a,5,7-triolMethyl (R)-3-methyl-2-oxopentanoate1,2-Cyclohexanediol, 1-methyl-4-(1-methylethenyl)-LysoPE(0:0/20:3(11Z,14Z,17Z))Cyprodinil5-Dihydroxyhept-6-enoic acidAndrosterone glucuronidePhosphoribosyl formamidocarboxamideIndole-3-ethanolParamethadioneLysoPE(0:0/20:3(5Z,8Z,11Z))Isopentyl gentiobioside6-Acetyl-2,3-dihydro-2-(hydroxymethyl)-4(1H)-pyridinoneGentisate aldehydeDiazepineAvocadyne3-Methyloxindole(3S,5R,6S,7E,9x)-7-Megastigmene-3,6,9-triol 9-glucosideLauroyl diethanolamide6-Keto-prostaglandin F1a3- Hydroxyindolin-2-one-sulfateCeruleninHydroxytriamterene sulfateo-CresolL-Arginine phosphateTetrahydrogestrinoneL-Ascorbic acid26-Glucosyl-1,3,11,22-tetrahydroxyergosta-5,24-dien-26-oateLysoPE(0:0/15:0)1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1h-pyrrole-3-carboxamideGalabiosylceramide (d18:1/26:0)Isopropyl 3-methylbutanoateL-AMPMethyl 2-octynoateGlycochenodeoxycholateFluphenazine decanoateChrycolideLysoSM(d18:0)10,11-dihydro-20-dihydroxy-LTB4(R)-2-Hydroxycaprylic acidProstaglandin B22-Hydroxycinnamic acid5-Amino-6-(5'-phospho-D-ribitylamino)uracilcis-3-Hexenyl hexanoate(3-{[3-(2-Amino-2-Oxoethyl)-1-Benzyl-2-Ethyl-1h-Indol-5-Yl]oxy}propyl)phosphonic Acid8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylateL-TyrosineN-Formimino-L-glutamateDigalacturonate5beta-Cholestane-3alpha,7alpha,12alpha-triolPS(16:0/20:0)N-(Carbethoxyacetyl)-4-chloro-L-tryptophan(R)-1-Methylpiperidine-2-carboxylic acidPenicillamine cysteine disulfidePC(18:0/PGF1alpha)PrallethrinL-PhosphoarginineE-10-HydroxyamitriptylineViolaceingamma-AminobutyryllysineThioguanineSpheroidenoneRiddelliine N-oxideD-Glucaro-1,4-lactoneCinalukastEucalyptol10-Deoxymethynolide4-Hydroxy-2-quinolinecarboxylic acidChakanoside ICandoxatrilat2-Hydroxyundecanoate3b,12a-Dihydroxy-5a-cholanoic acid2,5-Dihydroxybenzaldehyde4'-O-Methyl-(-)-epicatechin 3'-O-glucuronidetrans-3,3',4',5,5',7-HexahydroxyflavanoneHarmalolD-Glyceraldehyde 3-phosphate(1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol(S)-10,16-Dihydroxyhexadecanoic acidall-trans-3,4-DidehydroretinolNatamycinLysoPE(0:0/20:2(11Z,14Z))ADP-ribose 2'-phosphate(2R,3S)-3-Hydroxy-1,1-dimethylpyrrolidin-1-ium-2-carboxylateHydroxytyrosol 3'-sulfateLividamine9,12,13-TriHOME5-MethylthioriboseIslanditoxinVolasertib11-Dehydro-thromboxane B2Valeric acid1-(9Z-tetradecenoyl)-glycero-3-phosphateVirginiamycindelta-Guanidinovaleric acidDeoxycholylasparagineN(omega)-Hydroxyarginine6-Hydroxy-5-methoxyindole glucuronide4,4'-DihydroxyantipyrineLysoPE(0:0/16:0)13'-Carboxy-alpha-tocopherol4-Hydroxy-N-phenyl-3,5-bis(1-pyrrolidinylmethyl)benzamideSuberic acid2-MethylbutyrylglycineCheirotoxolLysoPC(16:1(9Z)/0:0)Galactonic acidPE(20:0/20:1(11Z))6-GingerolEthyl maltolCoumestrinVofopitant5-BenzylacyclouridineDihydroresveratrol 3-glucuronide4,4'-Dihydroxy-5,5'-diisopropyl-2,2'-dimethyl-3,6-biphenyldioneHept-4-enedioylcarnitine3-HydroxyoctanoateMalabaricone CGancaonin CMethyl (R)-8-Hydroxy-9-decene-4,6-diynoate glucoside2-Methoxy-estradiol-17beta 3-glucuronide1-heptadecanoyl-glycero-3-phosphate13-Tetradecene-1,3-diyne-6,7-diolTaurolithocholic acid3-(2-Butynyl)-5-methyl-2-(piperazin-1-yl)-3,5-dihydroimidazo[4,5-d]pyridazin-4-one1,2-CyclohexanediolAnnocherine BTRPM8 antagonistPE(18:0/20:2(11Z,14Z))Licoagrochalcone B3-Formyl-6-hydroxyindoleDopamine quinone1-palmitoyl-dihydroxyacetone-phosphateParomomycin3-Methoxy-4-hydroxyphenylacetaldehyde11-deoxy-11-methylene-PGD2Deoxycholic acid 3-glucuronideIcofungipen4'-(Imidazol-1-yl)acetophenoneOsmundalactone3-Oxovalproic acidPalmitic amideDialdehyde8,9-DHETLysoPC(0:0/16:0)TrifluridineBilirubinCycloserineHippurate5-MethyldeoxycytidinePE(18:0/20:1(11Z))Benzoyl glucuronide (Benzoic acid)L-Hypoglycin A3-(Hydroxymethyl)-5-oxopentanoic acidS-MethylthiocitrullineLithocholate 3-O-glucuronidePS(18:1(9Z)/0:0)2'-DeoxyuridineMenaquinol3-Sulfopropyl methacrylatePerillyl aldehyde9-Oxononanoic acidWarfarin1-deoxy-L-glycero-tetrulose 4-phosphate(R)-3-Hydroxy-Octadecanoic acidFloionolic acidL-Methionine S-oxide10-(Phosphonooxy)decyl methacrylateHydroquinoneBisphenol BAcetaminophen glucuronideBenzoyl L-arginine methyl ester9-Hydroxybenzo[a]pyrene-4,5-oxideNesbuvirL-GlutamateBupirimateImazamethabenz-methylSodium deoxycholatePIP(22:4(10Z,13Z,16Z,19Z)/PGF2alpha)PE(20:0/TXB2)ChalconosakuranetinLysoPE(P-18:0/0:0)DG(13:0/18:1(12Z)-O(9S,10R)/0:0)PE(18:0/22:2(13Z,16Z))SM(d18:1/16:0)6-n-Propyluracil4-Carboxypyrazole2,4-Pyrimidinediamine, 5-(5-(1-piperazinylmethyl)-1,3,4-oxadiazol-2-yl)-N4-propyl-N2-(2-(4-pyridinyl)ethyl)-L-Oleandrosyl-oleandolideCDP-DG(i-14:0/20:4(6E,8Z,11Z,14Z)+=O(5))(2E,4E,7E)-Nona-2,4,7-trienoylcarnitine4-Hydroxyatomoxetine5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl esterBiocytinMaltolD-Xylono-1,5-lactoneTaxa-4(20),11(12)-dien-5alpha,13alpha-diolD-UrobilinogenDimethylthiambuteneSulfate[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl (2S,3S)-2-amino-3-methylpentanoateRiociguatToluene-4-sulfonateTaurineLysoPE(0:0/18:0)p-HydroxyphenylacetylglycineLeukotriene F4Histidylproline diketopiperazine4-(4-(Chloromethyl)phenyl)morpholin-3-oneAurintricarboxylic acid1-(6Z,9Z,12Z-octadecatrienoyl)-glycero-3-phosphateGeranylacetoneN'-FormylkynurenineFutalosine1,11-Undecanedicarboxylic acid3-DehydroecdysoneGuanosine diphosphate5-Hydroxyvalproic acid2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid6-ThiourateJubanine A5-Deoxyribose-1-phosphate5-Hydroxymethylflucloxacillin3'-(2''-Galloylglucosyl)-phloroacetophenoneBis(2-hydroxyethyl) terephthalateMyxinGlycerol2,4,5-TrimethoxybenzaldehydeNitroparacetamol1-O-Sinapoylglucose5-EthyluracilPentostatinLysoPC(22:4(7Z,10Z,13Z,16Z)/0:0)EugeninEthyl hexadecanoate19-Hydroxyandrost-4-ene-3,17-dione5-HydroxykynurenamineDihydroceramideFostriecinPS(15:0/20:1(11Z))LinezolidButenylcarnitineDiphenol glucuronidePE(18:3(9Z,12Z,15Z)/20:0)12-OPDACitrininPyrrole-2-carboxylic acidCarnosineKiwiionosideDeferoxamineLysoPC(20:5(5Z,8Z,11Z,14Z,17Z)/0:0)D-Glutamine1-Ethyl-1-nitrosoureaOsmaroninLeukotriene C41-Heptadecanoylglycerophosphoethanolamine3',4',5'-TrimethoxyflavonolPA(19:0/22:0)L-(+)-GuloseUrateL-Tryptophan3alpha,7alpha,12beta-Trihydroxy-5beta-cholanoic acidIsopropamideO-Phenolsulfonic acidMethyl 2-undecynoate3-(5-Methyl-2-furyl)prop-2-enalDeoxyuridineLipid XPhenylacetylglycine7,8-Dihydroneopterin 3'-triphosphateIlicifolinoside Asecologaninalpha-Fluoro-beta-ureidopropionic acidLysoPC(18:1(9Z)/0:0)Mesoxalaldehyde1-hexadecyl-glycero-3-phosphateEstrone glucuronide3,4-Dihydroxy-5-[(S)-1,2-dihydroxyethyl]furan-2(5H)-oneFurazolidonePE(18:2(9Z,12Z)/20:0)4,8 Dimethylnonanoyl carnitine(2E)-Hexenedioylcarnitine3-Hydroxy-2H-pyran-2-oneD-Glucono-1,5-lactone 6-phosphateUracilSphingosyl-phosphocholine2-ThiouracilS-Nitroso-N-acetylcysteine5-Hydroxy-3,3',7,8-tetramethoxy-4',5'-methylenedioxyflavoneLysoPC(18:3(6Z,9Z,12Z)/0:0)TryptamineN-AcetylserotoninLysoPE(0:0/20:0)UDP-4-dehydro-6-deoxy-D-glucoseAmisulprideMorphinecis-9,10-Epoxystearic acidCreatine1,8-Naphthyridine, 2-fluoro-CortolAlizarinN2-gamma-GlutamylglutamineSphingosine 1-phosphate2,3-Diaminopropionic acidFluperlapineL-Glutamyl 5-phosphateNirvanolDegalloyltheaflavoninEduleine6-Ketomyristic acidOxamniquine4-Hydroxyantipyrine(2S)-3-Hydroxy-1-[(2S)-pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acidPalmitoyl glucuronideponasterone A3-Hydroxyarachidonoylcarnitine2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine12-Hydroxydihydrochelirubine5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylateGlucosamine 6-sulfateL-Malic acidSimazineGevotrolinePS(16:0/20:1(11Z))9(S)-HODEL-2,3-Diaminopropanoate3-Hexaprenyl-4,5-dihydroxybenzoateMethymycinMetribuzinPS(24:0/18:3(10,12,15)-OH(9))HypoxanthineGluconolactonePsilocybineDechlorodiazepamTheaflavic acidPhenylglucuronideMyricanoneSeptacidin(8S,9S,10R,11S,13S,14S,17S)-11,17-Dihydroxy-10,13-dimethyl-17-prop-1-ynyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthren-3-oneIslatravirRhizocticin A2,3-Dihydro-5-(5-methyl-2-furanyl)-1H-pyrrolizine3-Fumarylpyruvate4-Hydroxycyclohexylcarboxylic acid1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate(E)-8-Hydroxy-2-octene-4,6-diynoic acidL-Lactic acid3-(2-Furoyl)quinoline-2-carboxaldehydeOxaloglutaratehydroxynonenalPhenyl glucuronide15(S)-HPETEGlutaconic acidPyruvateAgarAzitromycin1-(11Z-docosenoyl)-glycero-3-phosphate1-Oleoyl-sn-glycero-3-phosphocholineLysoPC(16:0/0:0)Taurolithocholate sulfate7-Hydroxyterpineol 8-glucosidetrans-Hexadec-2-enoyl carnitine(S)-2,3-Dihydro-7-hydroxy-2-methyl-4-oxo-4H-1-benzopyran-5-acetic acidMono-methyl-adipateEthyl 2-methyl-3,4-pentadienoate2-Phenylethanol glucuronide3-Hydroxyphenylacetic acidOleandolideLysoPC(22:2(13Z,16Z)/0:0)Gentamicin A sulfate(3S)-3,6-DiaminohexanoateMonoethyl malonic acid(R)-2-Benzylsuccinate1-[(4-Amino-3-methylphenyl)methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acidAbscisic aldehydeCefadroxil4-ethylamino-6-isopropylamino-1,3,5-triazin-2-ol4-cholesten-7α,12α,24-triol-3-one3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestaneSucrose alcohol5-Amino-6-(1-D-ribitylamino)uracilTyramineMitomycinCholestane-3,7,12,25-tetrol-3-glucuronidePhenylbutazoneTrinexapac-ethyl3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-alPhysalin LHydroxypropionylcarnitine3-Hydroxy-4-butanolideSebacic acidKetone Ester15-Acetoxyscirpene-3,4-diol 4-O-a-D-glucopyranosideQuercetin3-Dehydroquinate2-Hydroxyglutaric acid diethyl ester(S)-Dihydroorotate27-NorcholestanehexolLysoPE(0:0/22:0)IsovalerylglucuronideFludrocortisone2-(6-Hydroxy-4-oxo-2-sulfanylidene-1H-pyrimidin-5-yl)propanedialTalarozoleN2-Fructopyranosylarginine6-HydroxymelatoninFluparoxanOlitorinCromakalimVulgaxanthin II(S)-3-Sulfolactate(R)-3-Hydroxy-hexadecanoic acidDL-2-hydroxy stearic acidPropyl 2-furoateGinsenoyne BL-2-Amino-3-methylenehexanoic acid4-Fluorocyclohexane-1-carboxylic acidDihydrofolate2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine4-Imidazolone-5-propanoate4-Hydroxyphenylacetylglutamic acid1-(3-Methyl-2-butenoyl)-6-apiosylglucoseIophendylateButanal4-Hydroperoxy-2-nonenalXanthineTocainideStavudine triphosphate2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphateN-(L-Arginino)succinate2-n-Propyl-4-oxopentanoic acid16alpha-Hydroxyestrone3-Hydroxyisoheptanoic acid2-Hepteneoylglycine3-Cresotinic acidLavoltidine19-EpischolaricinePanaquinquecol 15-Heptadecyl-1,3-benzenediol26-Desglucoavenacoside AXanthosine 5'-phosphate4-AzidobenzenesulfonamideThymidineTranexamic AcidL-IsoleucineS,S-Dimethyl-beta-propiothetin3-MethylglutarylcarnitinePantetheineGemcitabine diphosphate5-O-Caffeoylshikimic acidIsopropyl-beta-D-thiogalactopyranosideMedinaO-methylmalonyl-L-carnitine2-Ethyl-4-hydroxy-5-methyl-3(2H)-furanoneAsymmetric dimethylarginineDrostanolone4-HydroxyphthalideLysoPE(16:0/0:0)2'-Fluoro-2',3'-dideoxyinosineIndoxyl sulfateDG(PGE2/20:0/0:0)2,6-Dihydroxy-3-cyanopyridineNonateN-(N-(3-Carboxyoxirane-2-carbonyl)leucyl)isoamylamineTetracyclineGlycochenodeoxycholic acid 3-glucuronideLysoPC(15:0/0:0)Calenduloside ELysoPC(20:0/0:0)APGPR EnterostatinGlutathionyl-3-hydroxykynurenine glucosideChorismate3-[(2-Oxoacetyl)oxy]-4-(trimethylazaniumyl)butanoateTraumatinCaryoptosidic acid6,7-Dimethyl-8-(1-D-ribityl)lumazineLysoPC(22:5(4Z,7Z,10Z,13Z,16Z)/0:0)CDP-DG(i-12:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4))L-TarginineVirginiamycin S1Thromboxane B215S-HETE-d8D-Glucono-1,5-lactone3-Oxooctanoic acidAzelaic acidAscorbyl PalmitateLysoPC(P-18:0/0:0)Alkaloid AQC2Octadecyl fumarate1-heptadecanoyl-sn-glycero-3-phosphocholine1,3-Dimethyluracil1-(3-Hydroxy-5-methyl-2-thienyl)ethanoneall-trans-3,4-Didehydroretinoate1-Palmitoyl-sn-glycero-3-phosphocholineAminofurantoinSalicyluric acidP1,P4-Bis(5'-uridyl) tetraphosphateEthyl methylphosphonofluoridateMarinobufageninMethylphosphonothiolate3'-AMP1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthaleneEthyl 3-oxohexanoateDiethyl 6-methoxy-5,7-dihydroindolo[2,3-b]carbazole-2,10-dicarboxylate2,3-Dihydroxybenzoic acidSulfite(Z)-3-Hexen-1-ol acetate3,5,7-Trihydroxy-4',6-dimethoxyflavanoneMethacycline(R)-Lipoic acidLysoPS(18:2(9Z,12Z)/0:0)5a-TetrahydrocorticosteroneTaurochenodeoxycholate-7-sulfate5-Hydroxy-L-tryptophan3-Oxohexadecanoic acidfalseSerum LC-MS metabolomics profiling during musk secretion in captive forest musk deer (Moschus berezovskii)This study investigates serum metabolomic changes associated with musk secretion in captive male forest musk deer (Moschus berezovskii). Paired serum samples were collected before secretion and during secretion and analyzed using LC-MS in both positive and negative ion modes. The study includes biological samples and pooled quality-control samples and aims to characterize hormone-related metabolic remodeling during the musk secretion period.2026-04-232026-04-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