MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14356/m_MTBLS14356_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14356/m_MTBLS14356_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14356/a_MTBLS14356_LC-MS_positive_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14356/s_MTBLS14356.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14356/a_MTBLS14356_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14356/i_Investigation.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14356<p>Metabolite annotation was performed by matching experimental mass spectral data, accurate mass measurements, and fragmentation patterns against reference databases including the Human Metabolome Database (HMDB) and the Metlin database. Metabolites were identified at level 2 or above according to metabolomics reporting standards.</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phase<p>Parameter Value[Chromatography Instrument]: Ultra-high performance liquid chromatography systemParameter Value[Autosampler model]: Thermostatted autosampler compatible with UHPLCParameter Value[Column model]: Waters HSS T3 chromatographic columnParameter Value[Guard column]: Waters HSS T3 guard column</p>Integrated Analysis of Gut Microbiota, Serum Metabolomics, and Proteomics Reveals Novel Associations With Clinical Symptoms in Patients With Cerebral Infarction.qiluhospital of shandong universityXingbang Wangfecesmass spectrometry assay<p>Fecal samples were thawed on ice, and an appropriate aliquot was mixed with ice-cold methanol-water solution for metabolite extraction. The mixture was vortexed vigorously, sonicated in an ice-water bath, and centrifuged at low temperature to precipitate proteins and debris. The supernatant was collected, filtered through a microporous membrane, and transferred to chromatographic vials for instrumental analysis.</p>Homo sapienshttps://www.ebi.ac.uk/metabolights/MTBLS14356Xingbang Wang. qiluhospital of shandong university. wangxingbang@qiluhospital.cn.<p>Raw mass spectrometry data were imported and processed using Progenesis QI software. Peak detection, alignment, noise reduction, and peak area integration were performed systematically to generate a matrix of metabolite features with corresponding peak intensities. Data normalization and quality control filtering were conducted to ensure reliability for subsequent statistical and identification analysis.</p>Treatmentwangxingbang@qiluhospital.cn<p>Human fecal samples were collected from subjects assigned to two groups, namely the CI group and the control group. All samples were immediately snap-frozen in liquid nitrogen after collection and stored at −80 °C until further pretreatment and metabolomic analysis, avoiding repeated freeze-thaw cycles to maintain metabolite stability.</p>MetabolomicsMetabolomicscerebral infarctionuntargeted analysisgutultra-high performance liquid chromatography systemHomo sapiensexperimental blankfecesAB SCIEX TripleTOF 5600Metabolomicscerebral infarctionuntargeted analysisgutultra-high performance liquid chromatography systemHomo sapiensexperimental blankfecesAB SCIEX TripleTOF 5600<p>Parameter Value[Scan m/z range]: 50–1500 m/zParameter Value[Instrument]: Triple TOF 5600 systemParameter Value[Ion source]: Electrospray ionization (ESI) sourceParameter Value[Mass analyzer]: Quadrupole time-of-flight (Q-TOF) mass analyzer</p>Dg(18:4(6z,9z,12z,15z)/15:0/0:0)Pe(15:0/16:1(9z))DG(a-15:0/5-iso PGF2VI/0:0)1-Nonadecanoyl-glycero-3-phosphoethanolaminePc(16:0/18:3(9z,12z,15z))2-(beta-D-Mannopyranosyl)-L-tryptophanIsobutyryl carnitine6-Methylpteridine-2,4-diamineLysoPC(0:0/18:2(9Z,12Z))DihydrokaempferolTetracosanoic acidNipecotic acidChenodeoxycholylglutaminePc(20:0/0:0)Beclomethasone 17-monopropionate9-cis-beta-CarotenePa(14:1(9z)/14:0)2,3-Dimethyl-2-cyclohexen-1-oneD-lysineN,N-DimethyloctanamidePE(DiMe(13,5)/20:3(6,8,11)-OH(5))7-Aminocephalosporanic acidPs(22:0/18:2(9z,12z))GPCho(20:2/20:5)N-Acetyl-D-tryptophanGant61Pe(20:0/20:4(5z,8z,11z,14z))3-(1-pyrazolyl)-alanine3-O-Sulfogalactosylceramide (d18:1/20:0)N6-Acetyl-L-lysineEremopetasidioneL-thyroxinePc(p-18:0/22:6)Ps(18:3(6z,9z,12z)/22:5(4z,7z,10z,13z,16z))Pe(p-16:0/0:0)Ent-17-hydroxy-16beta-kauran-19-al2-(3-Carboxy-3-(methylammonio)propyl)-L-histidineGln Asp Asp5-nitro-2-(3-phenylpropylamino)benzoic acidSolutol HS 15PromegestoneIsophoronePe(20:4(6z,8e,10e,14z)-2oh(5s,12r)/22:0)12-methyltridecanoic acidSalicylaldehydeDodecyl benzenesulfonate5-Hydroxyferulic acidBioadykinin Fragment 1-5(2S)-2-[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylamino]-4-sulfanylbutanoic acidLysoPC(14:1(9Z)/0:0)2-hydroxycinnamic acidMesteroloneDg(20:5(5z,8z,11z,14z,16e)-oh(18r)/0:0/15:0)Gentamicin C13,14-dihydro-15-keto-pga23-O-Sulfogalactosylceramide (d18:1/22:0)Alprazolam2-Cyclohexen-1-one2-[(2-Fluorophenyl)sulfanylmethyl]-5-[6-[(2-hydroxycyclopentyl)amino]purin-9-yl]oxolane-3,4-diol4-Hydroxyquinoline2-O-alpha-D-Glucopyranosyl-O-beta-D-galactopyranosylhydroxylysineDecadienyl-l-carnitineO-Propanoyl-D-carnitinePF-543 (Citrate)Methyl beta-orcinolcarboxylateGPEtn(17:1/17:1)D-GlucoseBisulepineIndoleN-Nervonoyl Cysteine[2-(3,5-Dimethoxy-4-hydroxycinnamoyloxy)ethyl]trimethylaminium2-benzoxazolinoneO-b-D-Gal-(1->3)-O-[O-b-D-Gal-(1->4)-2-(acetylamino)-2-deoxy-b-D-Glc-(1->6)]-2-(acetylamino)-2-deoxy-D-GalactoseDg(18:1(9z)/18:3(9z,12z,15z)/0:0)Promethazine sulfoxideLysoPE(20:5(5Z,8Z,11Z,14Z,17Z)/0:0)Ser pheLoliolide3-(Aminomethyl)-2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one4-[[4-(2,5-dimethylphenyl)-1,3-thiazol-2-yl]amino]-4-oxobutanoic acidDeoxycholyllysineL-Valine, N-(2-hydroxy-3-butenyl)-(8Z,10E)-Dodeca-8,10-dienoylcarnitine2-hydroxycarbamazepine3,5-dihydroxy-4-methoxybenzoic acidCyasteroneN-Acetyl-D-mannosamineLysoSM(d18:0)JWH 250 N-(5-carboxyxypentyl) metabolite4-hydroxynonenalPhenylalanine-betaxanthinHis phe trpL-glycineCay10580Emmolic acidN-[(2-fluorophenyl)methyl]-4-(5-methyl-1,3,4-oxadiazol-2-yl)phthalazin-1-amine4-aminovaleric acid betaineTrazodoneMyristoyllysophosphatidylcholinePectenotoxin 1EcgonineCarbamazepine-10,11-EpoxidePro-Pro-ProS-Allyl-L-cysteine(2E)-4-Hydroxy-3-methylpent-2-enedioylcarnitinePhytanic acidPe(22:0/22:2(13z,16z))PE-NMe2(22:4(7Z,10Z,13Z,16Z)/22:5(7Z,10Z,13Z,16Z,19Z))2,3-Dimethoxyphenol sulfate7-ethylguanineThr phe pheN-OleoyldopamineN-Undecanoylglycine1,3-ButadienePc(p-18:0/20:5)4-Dodecan-6-ylbenzenesulfonic AcidAcetaminophenPeg n7Ala Val IleCycloheterophyllin5'-HydroxypiroxicamAntiarrhythmic peptide(2R,4S)-4-Carbamimidamido-3-acetamido-2-((1R,2R)-2-hydroxy-1-methoxy-3-(octanoyloxy)propyl)-3,4-dihydro-2H-pyran-6-carboxylic acidSagittariolGlycyrrhetinic acidCholylprolineSerratolPe(p-18:0/22:6)SterigmatocystinDescladinose roxithromycin8-Isoprostane(S)-Propane-1,2-diol3-Phenyl-3-(pyridin-2-yl)propanoic Acid15-oxoede(9Z,11E,13S)-13-Hydroperoxyoctadeca-9,11-dienoylcarnitine8-hydroxyquinolineButanedioic acid, octenyl-Pc(20:5(5z,8z,11z,14z,17z)/20:3(8z,11z,14z))3 alpha,7 alpha,26-Trihydroxy-5beta-cholestaneGamma-TerpinenePentacarboxyl porphyrinogen IIIGPCho(22:5/15:0)CDP-DG(i-21:0/i-13:0)Leu Asp Gln Gln Vallevulinic acid, 3-benzylidenyl-CilengitideGPCho(18:2/20:5)MelanettinVeratramineDg(18:1(11z)/18:0/0:0)GynocardinPhenylalanyltryptophan(22R,23R)-22,23-dihydroxy-campest-4-en-3-onePe(16:1(9z)/20:1(11z))Indole-3-carboxaldehydeGangliotetraosePro PheBeta-Hederin(+/-)-OctanoylcarnitineSN38 glucuronideDehydroeburicoic acid4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]butanoic acidFlephedronePc(20:5(5z,8z,11z,14z,17z)/p-16:0)Asp-PheSM(d18:2(4E,14Z)/PGE2)Austinoneol1h-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-oneApramycinPs(16:0/16:0)Albanin GPe(22:4(7z,10z,13z,16z)/p-16:0)Ganosporelactone ATaurochenodeoxycholic acid1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholineMyrigalone A3,4-dihydroxyphenylacetic acidRoxithromycinAzimexonDodecyl 3-[3-(7-hydroxydodecoxy)-3-oxopropyl]sulfanylpropanoate(3-hydroxyheptadecanoyl)lysineAllysinePhe gluPa(16:1(9z)/16:0)Asp LeuPs(14:0/pgj2)(11R,12S,13S)-Epoxy-hydroxyoctadeca-cis-9-cis-15-dien-1-oic acid4-Hydroxy-4-(3-pyridyl)-butanoic acidPg(20:2(11z,14z)/18:2(9z,12z))1-phenyl-2-butanonePe(p-18:1(9z)/22:6(4z,7z,10z,13z,16z,19z))Pe(16:0/14:0)Hupehemonoside23-HydroxyphysalolactoneCer(d18:2(4E,14Z)/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15))O-GlutarylcarnitineNeoacrimarine FCer(d20:1/LTE4)Pe(24:1(15z)/18:1(12z)-2oh(9,10))3-O-Sulfogalactosylceramide (d18:1/24:0)TamsulosinMilbemycin A3Lipofectin6-aminocaproic acidEthyl myristate2-(tert-butyl)-8-[(3,4-dichlorobenzyl)oxy]imidazo[1,2-a]pyridineDG(PGE1/0:0/i-16:0)Janthitrem CJanthitrem BN-(2,4-dimethylphenyl)-2-phenylimidazo[1,2-a]pyrazin-3-amineIsoleucylproline2-(4-Chlorophenoxy)propionic acidCinncassiol D15'-deoxy-5'-methylthioadenosineRetreversineLithocholenic acidMethionyl-IsoleucineNelfinavirNeopellitorine AOryzalexin E2'-deoxyguanosine 5'-monophosphate13-Methyltetradecanoylcarnitine(1Ar,3S,4aS,7S,8aS)-3-[(1S,2R,3R)-3-[(2R,5S)-5,6-dimethylheptan-2-yl]-2-(2-hydroxyethyl)-2-methylcyclopentyl]-7-hydroxy-4a-methyl-2,3,5,6,7,8-hexahydro-1aH-naphtho[4,4a-b]oxiren-4-oneTrp LeuErythromycin A enol etherMenthyl ethylene glycol carbonate(17alpha,23S)-17,23-Epoxy-29-hydroxy-27-norlanosta-1,8-diene-3,15,24-trione2-Azaspiro[4.5]decan-3-oneGanoderic acid K2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diolGanoderic acid FHematoporphyrinPe(18:4(6z,9z,12z,15z)/22:6(4z,7z,10z,13z,16z,19z))6-Ethyl-5-Hydroxy-3-oxa-1-azatricyclo[5.3.1.04,11]undec-7-en-2-one6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dioneGanolucidic acid AUbiquinone-8GPCho(22:6/18:0)Momorcharaside BPpaPe(14:1(9z)/22:2(13z,16z))Trans-3-indoleacrylic acidGeranylgeraniolMethyl 1-[2-(2,5-dimethoxyanilino)-2-oxoethyl]indole-3-carboxylateArachidonoylcarnitinePe(14:0/14:0)Pc(24:0/18:4(6z,9z,12z,15z))Rhoifolin2-linoleoyl glycerolCetraxateBeta-eudesmolLeucomycinOctopamineTriethanolamineImidazolone ACholesterol glucuronidePs(16:0/18:3(9z,12z,15z))16,17-Dihydro-16alpha,17-dihydroxygibberellin A7 17-glucosidePs(18:4(6z,9z,12z,15z)/14:0)Menaquinone 82-aminopropanolPA(8:0/i-21:0)Ophiopogonoside aCinncassiol C316b-HydroxystanozololIlicifolinoside APE-NMe2(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:4(7Z,10Z,13Z,16Z))ErythromycylaminePro-leuMorpholineFurazolidoneDibutyl sebacateHistidylasparagineUracilCuminaldehydeOmega-3 arachidonic acidPc(p-20:0/22:5)PhloroglucinolCreatine(13Z)-3-Hydroxyicos-13-enoylcarnitineHis-trp2-HydroxybiphenylSphingosine 1-phosphateMjdbissp00000001Pe(20:0/pgd1)N-(3-acetamidopropyl)pyrrolidin-2-one6-(methoxymethyl)-2-(2-methyl-1,3-thiazol-4-yl)pyrimidin-4-olMjdbissp00000002Ps(20:0/20:1(11z))SM(d18:1/18:0)Mjdbissp00000009ScolymosideCholesterol sulfateLys Leu GlnRisperidoneN6-Methyl-2'-deoxyadenosine3-(3-hydroxy-4-methoxyphenyl)propanoic acidHarderoporphyrinogenErythromycinPaliperidonePro leuN-(4-Amino-2,5-diethoxyphenyl)benzamide3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate2-[4-[[4-([1,2,4]triazolo[4,3-a]pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]ethanolDiflufenican2-oxobutanoic acid12-oxo-PDA3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)propionic acidDehydroandrographolide succinate2-[1-oxo-1-(4-pyridin-2-ylpiperazin-1-yl)propan-2-yl]-3H-isoindol-1-one3-Hydroxy-5,5,8a-Trimethyl-3,4,4a,6,7,8-Hexahydronaphthalene-2-Carboxylic AcidS-Butylcysteine sulfoxide4-[6-[(2-phenyl-1,3-thiazol-4-yl)methylsulfanyl]pyrimidin-4-yl]morpholineEnterolactone2-methylindoleStatineIreneHypaphorineTumonoic Acid IGPEtn(18:0/20:4)CulantraramineCholine PhosphateSalviolTuberculostearic acidPlactin DHexyl glucosideLeu Gly LeuBenazeprilatAgarN-alpha-Acetyl-L-citrulline(10Z,12E)-HexadecadienoylcarnitineL-DOPA n-Butyl Ester4-(2,6-dimethylimidazo[2,1-b][1,3,4]thiadiazol-5-yl)sulfonylmorpholineTrp glu gluMangicrocinMetazinSer gln tyrUrea glutamateGentamicin C2LysoPE(0:0/20:4(8Z,11Z,14Z,17Z))Dg(18:4(6z,9z,12z,15z)/14:0/0:0)1-Acetamidocyclopentanecarboxylic acidDeethylatrazine1-{[5-methyl-2-(trifluoromethyl)-3-furyl]carbonyl}-4-piperidinecarboxylic acid4,5-DihydrovomifoliolPe(22:5(7z,10z,13z,16z,19z)/22:4(7z,10z,13z,16z))Pc(32:0)Methiocarb-sulfoxide phenolDg(18:3(9z,12z,15z)/15:0/0:0)3,6,9,12,15,18,21,24,27,30-decaoxadotriacontane-1,32-diolDimethyl Sulfoxide(+/-)-Clopidogrel1-stearoyl-2-linoleoyl-sn-glycero-3-phosphatidylcholineTyramine(3S,5R,8S)-5,8-Epoxy-5,8-dihydro-beta,beta-caroten-3-oloctadeca-10,12-dienoic acidPhysalin CDeoxycholylglutaminePropionic acidPyroglutamic AcidPro Asn Ser1-hexadecyl-2-(9z-octadecenoyl)-sn-glycero-3-phosphocholineValidamycin AN-(1,3-benzothiazol-2-yl)-1-(3-fluorobenzoyl)piperidine-4-carboxamideN-Myristoyl ArginineDiethyl phthalateErgothioneinePhenylphosphonic acid4-hydroxycinnamic acidAmafoloneAmikacinSM(d19:1/20:5(5Z,8Z,11Z,14Z,16E)-OH(18R))FidaxomicinDg(12:0/0:0/lte4)Pc(22:6(4z,7z,10z,13z,16z,19z)/22:2(13z,16z))1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol25-hydroxycholecalciferol8beta-Angeloyloxy-15-hydroxy-1alpha,10R-dimethoxy-3-oxo-11(13)-germacren-12,6alpha-olideMeOSuc-Ala-Ala-Pro-Val-PNAAsparaginylcysteineJurubine6-Hydroxypentadecanedioic acid4-(2-aminoethyl)-N-(3-methylphenyl)piperidine-1-carboxamideMet-enkephalinamideDioxaneHexamethoxymethyl melamineAfzelechinDG(PGJ2/i-14:0/0:0)O-AcetylcarnitineAlisol c monoacetateLaurenoniolideThr Lys Ser LysDecanoylcarnitinePc(p-18:1(9z)/18:4(6z,9z,12z,15z))8-hydroxy-9,10-epoxystearic acidcarbamazepine 10,11-epoxideTrandolaprilatDibenzylamineAcetylcysteineDg(8:0/0:0/20:5(7z,9z,11e,13e,17z)-3oh(5,6,15))Pc(22:6(4z,7z,10z,13z,16z,19z)/p-18:1(9z))GPCho(19:0/18:2)Salicyluric Acid3-(2,4,5-trimethoxy-phenyl)-propionic acid3-O-Protocatechuoylceanothic acid2',3'-DideoxyadenosineGymnodimine4-nitro-d-phenylalanineP-CresolCyanidin 3,5-O-diglucosideDg(20:2(11z,14z)/18:4(6z,9z,12z,15z)/0:0)Pc(18:2(9z,12z)/18:0)PE-NMe(20:4(5Z,8Z,11Z,14Z)/22:4(7Z,10Z,13Z,16Z))1-(3,4-Methylenedioxyphenyl)-2-aminopentanePalmitoylcarnitineN-(4-acetamidophenyl)-3-(4-chlorophenyl)imidazo[1,2-a]pyridine-2-carboxamide(-)-Epicatechin 3'-O-glucuronideAlpha-Campholonic acidCorydalineLysoPC(20:4(5Z,8Z,11Z,14Z)/0:0)Dg(14:1/18:4/0:0)DehydrozingeroneDG(6 keto-PGF1alpha/i-19:0/0:0)MonoacetyldiglycerideThreonylmethionineHeptadecasphinganineGlu Thr His Glu(1R,2R,4R,5S)-(+)-p-Menthane-2,5-diol6-methyl-5-Hepten-2-one5-nitro-2-phenylpropylaminobenzoic acid [nppb]PrenalterolDihydrothymineSM(d16:1/18:1)Tetranor-PGEM(4Z,7Z,10E,12E,16Z)-18-(3-Ethylcycloprop-1-en-1-yl)-14-hydroxyoctadeca-4,7,10,12,16-pentaenoylcarnitineLidofeninPc(22:4(7z,10z,13z,16z)/22:0)Ainidiol13-O-Tetradecanoylphorbol 12-acetatePantoprazoleN-Acetyl-b-glucosaminylaminePeg monooleate n84-Heptylphenol16-NitroxystearatePhenoxybenzamineVitamin aPs(22:1(13z)/22:0)SM(d16:1/18:0)Linolenic acid5,6-Dihydroxyprostaglandin F1aVitamin e4-ChlorophenylPregnanetriolPe(14:0/p-18:1(11z))Ethyl 3-hydroxyoctanoate O-[glucosyl-(1->6)-glucoside]6-(9-hydroxy-1,8-dimethylspiro[4.5]dec-7-en-4-yl)-2-methylhept-2-enal28-HomobrassinolideLaninamivirPs(24:0/16:1(9z))DG(a-15:0/0:0/20:3(8Z,11Z,14Z)-2OH(5,6))BufadienolideBenzyladenine 3-O-beta-D-glucosidePc(20:3(8z,11z,14z)/20:0)AminoglutethimideChlorobenzeneGPEtn(22:6/18:3)HyodeoxycholylglycineXi-7-Hydroxyhexadecanedioic acidAnisperimusPc(16:1(9z)/22:1(13z))Norepinephrine sulfatePhenolDG(20:5(5Z,8Z,11Z,14Z,16E)-OH(18)/0:0/a-13:0)1-indanoneAmlodipineRhodin G7Ps(15:0/16:1(9z))Ps(16:0/16:1(9z))7-Dodecenoylcarnitine5-Hydroxyindoleacetic acidGPEtn(14:0/22:2)Pc(18:1/0:0)(E)-4-[[(1R)-2-[[(2R)-2-(2-Adamantyloxycarbonylamino)-3-(1H-indol-3-yl)-2-methylpropanoyl]amino]-1-phenylethyl]amino]-4-oxobut-2-enoic acidPe(20:4(8z,11z,14z,17z)/15:0)Phylanthosiden-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-3-isoxazolecarboxamideTrp hisDG(20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15)/i-12:0/0:0)Pantothenic Acid1,4,7,10,13,16-HexaoxacyclooctadecaneParacetamolPhenylalanylhydroxyproline1-methyl-4-methylidene-7-propan-2-yl-2,3,3a,5,6,8a-hexahydroazulen-1-ol4-Hydroxy-6-pentacosanonePe(22:6(4z,7z,10z,13z,16z,19z)/20:0)Cer(d16:1/20:4(6E,8Z,11Z,13E)-2OH(5S,15S))Quinoline-4,8-diolN-methylserineMiglitol8-Hydroxy-5,6-octadienoic acidDecanoyl-l-carnitineIminostilbene2,7-acetylaminofluoreneGinkgolide B5-Fluorouridine monophosphate(3-phenyloxiranyl)methanolFluvoxamino acidPc(pgd1/22:3(10z,13z,16z))2-[4-(benzyloxy)phenoxy]-3-nitropyridine(Z)-7-[(1R,4S,5R,6R)-5-[(E,3S)-3-Hydroxyoct-1-enyl]-2,3-diazabicyclo[2.2.1]hept-2-en-6-yl]hept-5-enoic acidPhe ser alaPs(14:1(9z)/20:0)Urobilinogen(E)-5,8-Megastigmadien-4-oneArachidonic acid-biotin2-Amino-3-(3-fluoro-4,5-dihydroxyphenyl)propanoic acidPhytolaccatoxinD-pyroglutamic acidHaloxyfop-methylLysoPE(0:0/20:5(5Z,8Z,11Z,14Z,17Z))Pc(22:6/0:0)1-dodecyl-2-pyrrolidinoneIsopeopyl ParabenEriojaposide BVulgarolePe(20:3(5z,8z,11z)/pge2)Muricatin A3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, diethyl esterGPCho(20:5/20:5)R-4-benzyl-3-((R)-3-hydroxy-2,2-dimethyloctanoyl)oxazolidin-2-oneLysoPC(20:3(5Z,8Z,11Z)/0:0)Aspartyl-Serine18r-hepe2 Inverted exclamation marka,7 inverted exclamation marka-Dichlorodihydrofluorescein diacetate9(z),11(e)-conjugated linoleic acid1-Octen-3-yl glucosidePc(22:5/0:0)Chlorambucilcholesta-4,6-dien-3-oneIsoindolineMethyl 3-(isonicotinoylamino)-4-methylbenzoate3,4-edmaGlutarylcarnitineDiethanolamine3,4-DihydroxybenzaldehydeLeucyl-GlutamatePrim-O-glucosylcimifugin2-naphthoxyacetic acidCoumaryl acetateIndole-3-acetic acid4-(2-Nitroethyl)phenyl primeveroside1-arachidonoyl-2-hydroxy-sn-glycero-3-phosphateAlpha-Methylene-Gamma-ButyrolactonePc(18:2/0:0)Pc(20:4/0:0)SaxitoxinL-Tyrosine(Z)-3-Oxo-2-(2-pentenyl)-1-cyclopenteneacetic acid4-Methyl-1H-BenzotriazoleProstratinKinetensin 1-3UrapidilN-alpha-acetyllysine1-methyl-1-(oxolan-3-ylmethyl)-3-(3,4,5-trifluorophenyl)ureaSucroseDG(20:2n6/0:0/18:4n3)(1R,4E,6S,7S,17R)-4-Ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione2-Methyl-1,3-cyclohexadieneGPCho(15:0/17:1)MetoclopramideIle Val AlaLysoPA(20:4(8Z,11Z,14Z,17Z)/0:0)Gamma-tocopherol(3Z,6Z)-3,6-NonadienalCephaeline2-Methyl-2-phenylsuccinimideAmantadine4-HydroxybiphenylPc(20:3/0:0)LysoPC(18:1(11Z)/0:0)MilataxelPc(p-18:0/txb2)Benzoic aldehydeDg(18:0/20:4(8z,11z,14z,17z)/0:0)Pe(15:0/20:2(11z,14z))SwerosideAsp gly ilePgp(22:5(7z,10z,13z,16z,19z)/16:0)Pe(22:1(13z)/18:4(6z,9z,12z,15z))Pe(18:3(9z,12z,15z)/20:2(11z,14z))Levoglucosan13-hodeDec-7-enedioylcarnitine3-(Hydroxymethyl)-5,5-diphenylimidazolidine-2,4-dionePafenololPiperineBenzoic AcidSM(d14:1/18:1)1,3-Butyleneglycol dimethacrylateOgyline1-O-Isopentyl-3-O-octadec-2-enoyl glycerolSM(d19:0/5-iso PGF2VI)4-VinylcyclohexenePc(18:0/0:0)3-ketosphingosineTetrahydroalstoninePe(18:2(9z,12z)/14:1(9z))Pro pro lysTosufloxacinDG(i-16:0/0:0/18:1(12Z)-O(9S,10R))5-AcetoxydihydrotheaespiraneDg(13m5/11d3/0:0)5-Hydroxydec-7-enoylcarnitine3-Deoxy-D-glycero-D-galacto-2-nonulosonic acidGeranyl acetoneParomomycinRubiscolin-6N-Stearoyl Arginine4'-HydroxyclobazamMetronidazole-oh2-octenoyl carnitine1,1'-(2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-diyl)diethanoneCer[ns](d34:1)10,20-Dihydroxyeicosanoic acid3-Hydroxy-p-mentha-1,8-dien-7-alSM(d18:0/24:1(15Z)(OH))DG(15:0/0:0/18:4n3)(7Z,9Z,12Z,15Z,18Z,21Z)-Tetracosa-7,9,12,15,18,21-hexaenoylcarnitineUrobilinBetainePe(14:0/20:1(11z))Pe(18:4(6z,9z,12z,15z)/20:1(11z))Anhydroerythromycin1-hexadecylamineN-cycloheptyl-6-thiophen-3-ylpyridine-3-carboxamideGPEtn(20:2/18:4)MG(PGF1alpha/0:0/0:0)Ginsenoside rg1Floionolic acid2-acetyl-1,4,5,6-tetrahydropyridineLysoPE(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)Neocarzinostatin chromophoreHpddGHis Trp13(S)-Hydroperoxylinolenic acidMenthol-glucoronideIsoquinolineAloeresin dGlycohyocholic AcidEthylmorphineNigrosporapyrone DPs(24:1(15z)/24:0)Thr Ile ArgDG(10:0/PGF1alpha/0:0)4-Oxoretinol7-(5-Hexyl-3,4-dimethylfuran-2-yl)heptanoylcarnitineDodecanoic acidPE-NMe2(18:3(6Z,9Z,12Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))Piperonyl sulfoxidePc(16:1(9z)/p-18:0)N-(3-aminopropyl)morpholineHesperetin-7-O-glucuronide4-pyrimidine methanamine5-mapdb7-EthoxycoumarinPhe Ser1,3-dicyclohexylurea2-methylbutyroylcarnitineGPCho(20:5/22:6)Indoprofen5-hydroxyindole-3-acetic acidPunicic acidCer(d16:1/20:4(8Z,11Z,14Z,17Z)-2OH(5S,6R))SM(d19:0/22:6(4Z,7Z,10Z,13E,15E,19Z)-OH(17))Erythromycin CGPCho(22:5/16:1)GPCho(18:0/22:5)APC5-(3-Pyridyl)-2-hydroxytetrahydrofuranDG(i-13:0/0:0/22:6(4Z,7Z,10Z,12E,16Z,19Z)-OH(14))5b-Cholestane-3a,7a,12a,23R,25-pentolPa(18:4(6z,9z,12z,15z)/20:5(5z,8z,11z,14z,17z))Phe AspPc(18:3(9z,12z,15z)/p-18:0)3-hydroxytridecanoyl carnitinePyr-phe-ohLysoPI(20:4(5Z,8Z,11Z,14Z)/0:0)L-arginineGermacroneLoxoribine2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine2-(2-Thienyl)furanP-Mentha-1,3,5,8-tetraeneEpinepetalactoneGliadinsMuramic acid[4-((1Z)-2-(Acetylamino)-3-{[1-(1,1'-biphenyl-4-ylmethyl)-2-oxoazepan-3-YL]amino}-3-oxoprop-1-enyl)-2-formylphenyl]acetic acidGPCho(18:1/18:0)Vitamin D2 3-glucuronidePe(22:1(13z)/14:0)Undec-9-enoyl-CoAGlycolipidsStyreneGlutamyl-phenylalanine3-Methyl-1-butylamineL-PyridosinePelargonidin 3-sophorosideGlu-glnN-acetyl-l-tryptophanPs(16:0/14:1(9z))ButylisopropylaminePc(22:6(5z,8e,10z,13z,15e,19z)-2oh(7s, 17s)/22:0)Nor-3-methylfentanylCaryophyllene oxide3-hydroxy-5,5,8a-trimethyl-3,4,4a,6,7,8-hexahydronaphthalene-2-carboxylic acidGPCho(22:2/20:5)DaunorubicinVigabatrinPhosphateN-(2,3-dichlorophenyl)-4-[furan-2-ylmethyl(methyl)sulfamoyl]benzamidePentadecanoic acidActinodaphninePelargonidin 3-arabinosideSerotoninPc(p-16:0/22:1)DihydrozeatinSuccinylcholineLysoPE(0:0/20:3(8Z,11Z,14Z))GPCho(18:1/18:2)ZeranolBis(2-ethylhexyl) sebacateCycloleucineLeucylprolineCer(d18:2(4E,14Z)/PGE2)Ps(14:0/20:2(11z,14z))GPCho(20:3/20:4)Pc(22:6(4z,7z,10z,13z,16z,19z)/p-16:0)Trans-Cinnamic AcidO-(13-Carboxytridecanoyl)carnitinePe(20:1(11z)/15:0)2-naphtholn,n-diisopropylethylamine1-beta-D-Arabinofuranosyl-5-fluorocytosinePs(15:0/24:1(15z))Ganoderic acid MgPonasterone A4-hydroxybenzaldehydeHomoarginineN-Nervonoyl TyrosineAzaspiracidDihydrozeatin-O-glucosideLevulinic acid, 3-benzylidenyl-Pc(22:6(4z,7z,11e,13z,15e,19z)-2oh(10s,17)/22:0)15-Deoxy-d-12,14-PGJ2Cyclohexane1-Lyso-2-arachidonoyl-phosphatidatemethyl 3,4,5-trimethoxycinnamateD-glutamineHippuric acidN-[Bis(3-aminopropyl)amino]-N-hydroxynitrous amidePhosphatidylcholine lyso 18:05-Hydroxyoct-2-enedioylcarnitinePristimerin3-Hydroxyglabrol(4S,8R)-8,9-Dihydroxy-p-menth-1(6)-en-2-onePe(18:1(9z)/22:5(7z,10z,13z,16z,19z))Notoginsenoside R2(2S,3R)-2-Amino-3-[(2S)-2-amino-3-hydroxypropanoyl]oxybutanoic acidO-Methylganoderic acid OGalactosylsphingosineZataroside bMethylonePs(20:3(8z,11z,14z)/18:0)Chebi:6943913,14-Dihydro PGE1Pe(pge2/24:1(15z))LysoPE(0:0/20:4(5Z,8Z,11Z,14Z))Pc(18:3(6z,9z,12z)/22:5(7z,10z,13z,16z,19z))Baccatin IIIn2,n2-dimethylguanosineRadiclonic acidTropineSenecionine N-oxide3-O-Sulfogalactosylceramide (d18:1/26:1(17Z))Pe(18:3(6z,9z,12z)/20:2(11z,14z))DodecenoylcarnitineN6-ThreonylcarbamoyladenosineL-SerineDg(11d5/13d5/0:0)GPCho(22:6/20:4)OuabainDihydroxycarbazepineDiprotin APanthenol5-[4-(4-propan-2-ylpiperazine-1-carbonyl)piperidin-1-yl]-2-propylpyridazin-3-oneVardenafil citrateRiesling acetal3-indolepropionic acidPC(DiMe(11,3)/MonoMe(9,5))3,13-DihydroxytetradecanoylcarnitinePhenacetineSubaphyllineDeoxycholylglutamic acidGPCho(18:3/18:3)Pe(15:0/20:3(5z,8z,11z))PE(DiMe(11,5)/20:5(5Z,8Z,11Z,14Z,16E)-OH(18R))Kresoxim-MethylPhe phe serCaffeineCucurbitacin AGPCho(22:6/20:3)CarbamazepineCucurbitacin CSebacic acidL-Methioninen3-(2-mercapto-4-oxo-3,4-dihydroquinazolin-3-yl)nicotinamideCholdienic acidCucurbitacin SPs(18:1(9z)/20:1(11z))6-methylindole(22R,23R)-22,23-dihydroxycampesterolN-propyl cinnamateL-Menthyl (R,S)-3-hydroxybutyrate4-chloro-N-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]benzamidePenitrem ESM(d17:1/18:0)Penitrem BBasilolSM(d18:1/12:0)Stigmastanyl-phosphorylcholinePiperidinesPc(18:0/22:5(7z,10z,13z,16z,19z))Dodecanedioic acid4-Chloro-2-nitrobenzylalcoholGirollineDg(20:1(11z)/18:3(9z,12z,15z)/0:0)ButanalLansioside AEtodolac acyl glucuronideN-acetylsphingosine[1-(1-ethylindol-5-yl)sulfonylpiperidin-4-yl]-(4-phenylpiperazin-1-yl)methanone3-[[4,4-difluoro-3-(hydroxymethyl)piperidin-1-yl]methyl]benzonitrileExo,exo-1,8-Epoxy-p-menthane-2,6-diolGamma-glutamylphenylalanineMonotropeinDg(15:0/16:1(9z)/0:0)5,6-Dihydro-5-azacytidinePE(PGF1alpha/24:0)Triphenylphosphine Oxide5-HydroxyoctanoylcarnitineTranexamic AcidN-(3-Methyl-2-pyridyl)-3-phenylsuccinimideS-Allylcysteine7-MethylxanthosineAntibiotic 205t3PregnanetrioloneGlycylprolylargininePE-NMe2(15:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))Indole-3-acetaldehydeErucamideLpc(18:2)BufalinImiprothrinMelleinPs(20:4(5z,8z,11z,14z)-oh(19s)/20:0)1-Pyrroline-5-carboxylic acid4-hydroxy NonenalPc(22:5(4z,7z,10z,13z,16z)/p-18:1(9z))Pc(22:0/18:3(10,12,15)-oh(9))GPCho(14:0/20:2)1-eicosanoyl-sn-glycero-3-phosphocholineYangoninCoronaric acidArg Ser SerPhe leuTetramethylene sulfoxideN-Palmitoyl IsoleucineElaidic acidLacto-N-tetraose(4E,15Z)-Bilirubin7-Hydroxyoct-4-enedioylcarnitineHexadecanamideLpc(18:1)Taurodeoxycholic acid3-acetyl-11-keto-beta-boswellic acidPC(PGF1alpha/15:0)Cer(d16:1/LTE4)Dihomo-gamma-linolenic acid3,4-dihydroxy-5-all-trans-heptaprenylbenzoatePe(p-18:0/0:0)Pro-Pro-PheTernatinButyryl carnitinePc(p-16:0/20:4)Milbemycin beta2Pc(p-16:0/20:3)Avocadene5-Androstenediol1-methylbenzotriazolePe(22:6(4z,7z,10z,13z,16z,19z)/24:1(15z))Isoleucyl-thiazolidine4-(1-benzylpiperidin-4-yl)oxy-N-(2-methoxyethyl)piperidine-1-carboxamideN-Linoleoyl Serine3-O-Sulfogalactosylceramide (d18:1/18:0)AcetoleinGlycodeoxycholic acidGlu phePc(17:1/0:0)SM(d18:2(4E,14Z)/16:0)HenatinibfalseIntegrated Analysis of Gut Microbiota, Serum Metabolomics, and Proteomics Reveals Novel Associations With Clinical Symptoms in Patients With Cerebral InfarctionCerebral infarction (CI) is a major cause of adult disability and mortality worldwide. Mounting evidence supports the critical role of the gut–brain axis in cerebrovascular disease progression. This study aimed to characterize the alterations in gut microbiota, serum metabolome, and serum proteome in patients with CI, and to identify multi-omics signatures associated with clinical symptoms. A total of 20 CI patients and 20 healthy controls (HC) were enrolled. Fecal microbiota was profiled using 16S rRNA gene high-throughput sequencing. Serum metabolomics and proteomics were analyzed using ultra-high-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) and data-independent acquisition (DIA) proteomics, respectively. Spearman correlation and multi-omics integration were applied to explore the associations among microbiota, metabolites, proteins, and clinical indicators.2026-05-082026-04-23MTBLS14356HMDB0253367HMDB0011564HMDB0245858HMDB0003543HMDB0242104HMDB0000214HMDB0000070;HMDB0000716;HMDB0000070HMDB0000182;PW_C000118HMDB0060711HMDB0255976HMDB0000271;PW_C000185HMDB0000766HMDB0000148;PW_C000095HMDB0001280HMDB0000925HMDB0000355HMDB0000562HMDB0001921HMDB0001161HMDB0033206HMDB0001888HMDB0001906HMDB0000162;PW_C000106HMDB0002820;PW_C001712HMDB0303993HMDB0000056;PW_C000040HMDB0003357HMDB0013031HMDB0240687HMDB0000497HMDB0006692HMDB0241673HMDB0252563HMDB0000824;LMFA07070105;PW_C000658HMDB0014480HMDB0255737HMDB0000786;HMDB0002818;HMDB0000786HMDB0014731HMDB0003831HMDB0006029HMDB0000687;PW_C000540HMDB0000528HMDB0257396HMDB0060028HMDB0000552HMDB0258797HMDB0247775HMDB0242184HMDB0256111HMDB0000939HMDB0248929HMDB0256362HMDB0062735HMDB0011172HMDB0028854HMDB0006050HMDB0301753HMDB0246690HMDB0000172;PW_C000112HMDB0000060;LMFA01060003;PW_C000042HMDB0244484HMDB0003012HMDB0032628HMDB0246210HMDB0250769HMDB0012201HMDB0244908HMDB0011648HMDB0062590HMDB0028714HMDB0304653HMDB0003320HMDB0246423HMDB0032573HMDB0000159;PW_C000104HMDB0028832HMDB0250094HMDB0000959HMDB0002013;LMFA07070054HMDB0242140HMDB0012130HMDB0004231HMDB0302429HMDB0041892HMDB0030820HMDB0256365HMDB0241726HMDB0000247HMDB0241046HMDB0241704HMDB0002825;PW_C001714HMDB0015052HMDB0035830HMDB0029077HMDB0001645HMDB0012948HMDB0246106HMDB0241809HMDB0002038HMDB0036074HMDB0257190HMDB0012993HMDB0037560HMDB0006598HMDB0244231HMDB0252182HMDB0001190HMDB0001860;PW_C001234HMDB0304379HMDB0013678HMDB0302901HMDB0254366HMDB0254682HMDB0003269HMDB0011171HMDB0062769HMDB0035036HMDB0038732HMDB0244621HMDB0001480HMDB0241047HMDB0257922HMDB0251322HMDB0253282HMDB0245262HMDB0060526HMDB0259786HMDB0015541HMDB0033669HMDB0035798HMDB0003217;LMPK12050218HMDB0258266HMDB0033145HMDB0041901HMDB0005849HMDB0030459HMDB0060548HMDB0010715HMDB0303165HMDB0034073HMDB0040682HMDB0061918HMDB0254564HMDB0003634HMDB0004610HMDB0250352HMDB0242606HMDB0035433HMDB0060389HMDB0303208HMDB0259958HMDB0001932;PW_C001291HMDB0246489HMDB0241682HMDB0015324HMDB0251309HMDB0001889;PW_C001257HMDB0254737HMDB0259528HMDB0031535HMDB0004586HMDB0041717HMDB0039123HMDB0030030;LMFA05000566HMDB0029113HMDB0245063HMDB0253472HMDB0013302HMDB0258720HMDB0015652HMDB0002404HMDB0012317HMDB0242375HMDB0001944;PW_C001303HMDB0015102HMDB0004304HMDB0282432HMDB0029592;LMGL03012615HMDB0001925;PW_C001284HMDB0030085HMDB0041534HMDB0034484HMDB0032012HMDB0029495HMDB0061154HMDB0241695HMDB0241770HMDB0252779HMDB0259508HMDB0302089HMDB0241957HMDB0250357HMDB0036888HMDB0001885HMDB0258253HMDB0254740HMDB0011177HMDB0000671HMDB0011655HMDB0254077HMDB0258761HMDB0245529HMDB0241958HMDB0060989HMDB0243958HMDB0242050HMDB0014643HMDB0010323HMDB0252101HMDB0006240;HMDB0251697;HMDB0251697HMDB0241145HMDB0254727HMDB0001587HMDB0032582HMDB0031973HMDB0003312;LMPK12050038HMDB0254199HMDB0041044HMDB0247308HMDB0060753HMDB0000791HMDB0241144HMDB0059850HMDB0259730HMDB0015345HMDB0245807HMDB0257995HMDB0252539HMDB0015090HMDB0005038;PW_C002381HMDB0259191HMDB0013682HMDB0013912;HMDB0014021;HMDB0014021HMDB0304641HMDB0006699HMDB0061635HMDB0258750HMDB0301785HMDB0249359HMDB0060676;PW_C040604HMDB0304700HMDB0302135HMDB0254033HMDB0002894HMDB0252352HMDB0041768HMDB0255438HMDB0015202;PW_C009497HMDB0251483HMDB0253475HMDB0255195HMDB0031758HMDB0241743HMDB0010397HMDB0012623HMDB0004690HMDB0246092HMDB0037607HMDB0036761HMDB0060607HMDB0030115HMDB0014970HMDB0242753HMDB0010332HMDB0259610HMDB0035722HMDB0257722HMDB0033425HMDB0258946HMDB0243590HMDB0060450HMDB0243974HMDB0038539HMDB0029529HMDB0247534HMDB0015342;LMPK04000014;PW_C009624HMDB0248886HMDB0254205HMDB0031149HMDB0061020HMDB0028994HMDB0014937HMDB0241225HMDB0241333HMDB0245025HMDB0029049HMDB0260509HMDB0303181HMDB0000063;LMST02030001;PW_C000045HMDB0241975HMDB0030524HMDB0241388HMDB0254805HMDB0008681HMDB0013848HMDB0253793HMDB0008981HMDB0035329HMDB0256035HMDB0036439HMDB0061041HMDB0036442HMDB0241362HMDB0015346HMDB0240777HMDB0032914HMDB0005199;HMDB0042012;HMDB0042012HMDB0036659HMDB0252727HMDB0015527HMDB0241308HMDB0000712HMDB0253295HMDB0249840HMDB0290471HMDB0015227HMDB0010364HMDB0283696HMDB0254979HMDB0241914HMDB0241609HMDB0001008;PW_C000797HMDB0014257HMDB0241471HMDB0036811;LMPR0104080010HMDB0001547;LMST02030186;PW_C001190HMDB0247733HMDB0000034HMDB0245554HMDB0247885HMDB0033778HMDB0248559HMDB0030041HMDB0005076HMDB0039329HMDB0246557HMDB0244793HMDB0014827HMDB0241981HMDB0000944HMDB0284579HMDB0302397HMDB0286615HMDB0029586HMDB0011511HMDB0285677HMDB0241568HMDB0001999;PW_C001337HMDB0000399HMDB0302014HMDB0260831HMDB0260217HMDB0247831HMDB0039122HMDB0001054HMDB0028780HMDB0304187HMDB0257446HMDB0032104HMDB0297254HMDB0288167HMDB0034529HMDB0241641HMDB0035853HMDB0303326HMDB0038018HMDB0272289HMDB0010388HMDB0298374HMDB0256501HMDB0033244HMDB0008100HMDB0249402HMDB0263442HMDB0263047HMDB0252258HMDB0011335HMDB0114764HMDB0010389HMDB0254729HMDB0000252;LMSP01010001;PW_C000172HMDB0242096HMDB0259971HMDB0035990HMDB0011507HMDB0252956HMDB0277056HMDB0030471HMDB0010381HMDB0297217HMDB0298847HMDB0041547HMDB0256687HMDB0006772HMDB0246126HMDB0008068HMDB0008655HMDB0002157HMDB0012097;LMSP0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