Metabolite annotation was performed by combining retention time (RT) and m/z information. LC-MS features were annotated against the online HMDB and KEGG databases by matching exact molecular mass values. Metabolites were annotated when the mass error between observed and database values was less than 10 ppm, and molecular formulas were further validated using isotopic distribution measurements. An in-house fragment spectrum library was also used to support metabolite identification. Feature extraction and annotation were performed using XCMS, CAMERA and metaX.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - negative - reverse-phase","Liquid Chromatography MS - positive - reverse-phase"],"chromatography_protocol":["Chromatographic separation was performed on a Waters ACQUITY UPLC I-Class system equipped with an ACQUITY UPLC HSS T3 column (1.8 µm, 2.1 mm × 100 mm; Waters). The column oven was maintained at 40°C. Mobile phase A consisted of water containing 5 mmol/L ammonium acetate and 5 mmol/L acetic acid, and mobile phase B was acetonitrile. The flow rate was 0.35 mL/min and the injection volume was 4 µL. The gradient elution program was: 0–1 min, 2% B; 1–9 min, 2–50% B; 9–12 min, 50–98% B; 12–13.5 min, 98% B; 13.5–14 min, 98–2% B; 14–20 min, 2% B.
"],"publication":["Mechanistic profiling of Bifemetstrobin against the tea anthracnose pathogen and candidate evaluation of an amine oxidase target."],"submitter_name":["xinpeng zhang"],"submitter_affiliation":["Guizhou University"],"organism_part":["leaf"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["Metabolites were extracted from tea leaf samples prior to LC-MS analysis. All samples were randomized before instrumental analysis. To monitor analytical reproducibility and instrument stability, pooled QC samples prepared by mixing equal aliquots of all processed samples were injected throughout the analytical run, including the beginning, middle and end of the sequence. Samples were analyzed in both positive and negative ionization modes.
"],"organism":["Camellia sinensis"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS14357"],"author":["xinpeng zhang. Guizhou University. zhangxinpeng175@163.com."],"data_transformation_protocol":["Raw LC-MS data were converted to mzXML format and processed using XCMS, CAMERA and metaX implemented in R. Data preprocessing included peak picking, peak grouping, retention time correction, second peak grouping, and annotation of isotopes and adducts. Metabolite data were then filtered to remove features with more than 80% missing values in biological samples or more than 50% missing values in QC samples, followed by K-nearest neighbor (KNN) imputation and probabilistic quotient normalization (PQN). Statistical analyses were performed in R (version 4.0). PCA and differential analysis were performed using metaX, PLS-DA using ropls, correlation analysis using Pearson correlation in cor, and heatmaps using pheatmap.
"],"study_factor":["Treatment"],"submitter_email":["zhangxinpeng175@163.com"],"sample_collection_protocol":["Tea leaf samples from Camellia sinensis were collected for untargeted metabolomics analysis. Samples included tea leaves treated with bifemetstrobin for 24 h, tea leaves inoculated with Glomerella cingulata for 24 h, and tea leaves treated with bifemetstrobin together with G. cingulata inoculation for 24 h. The study included CK, BF, GC and BGC groups, each with six biological replicates. Quality control (QC) samples were prepared separately for instrumental monitoring.
"],"omics_type":["Metabolomics"],"study_design":["Metabolomics","Camellia sinensis","Infectious disease caused by plant","untargeted analysis","Tea blender","Waters ACQUITY UPLC I-Class System","Guizhou University","XCMS","experimental blank","leaf","AB SCIEX TripleTOF 6600"],"curator_keywords":["Metabolomics","Camellia sinensis","Infectious disease caused by plant","untargeted analysis","Tea blender","Waters ACQUITY UPLC I-Class System","Guizhou University","XCMS","experimental blank","leaf","AB SCIEX TripleTOF 6600"],"mass_spectrometry_protocol":["Negative assay
Mass spectrometry detection was performed using an AB SCIEX TripleTOF 6600 high-resolution tandem quadrupole time-of-flight mass spectrometer with electrospray ionization in negative ion mode. The full scan acquisition range was 60–1200 m/z.
Positive assay
Mass spectrometry detection was performed using an AB SCIEX TripleTOF 6600 high-resolution tandem quadrupole time-of-flight mass spectrometer with electrospray ionization in positive ion mode. The full scan acquisition range was 60–1200 m/z.
"],"metabolite_name":["Coniferaldehyde","Myrtenal","Fluoroacetic acid","Chloridazon","pyroglutamylproline","4-(4-Methylphenyl)-2-butanone","Guaiacol","(4-Hydroxy-3-methoxyphenyl)ethanol","alpha-Bisabolol","Quinoline","Altretamine","2-Pyridylacetic acid","8-Hydroxy-7-methylguanine","2-Keto-6-acetamidocaproate","(S)-4-Hydroxymandelonitrile","Reserpine","Cuminyl alcohol","m-Aminobenzoic acid","8-hydroxymirtazapine","Citrulline","Anileridine","1,3,9-Trimethylxanthine","Tropolone","Nepsilon-trimethyllysine","Sophocarpine","Capryloylglycine","Alpha-Linolenoyl ethanolamide","1-Methylpyrrole","4-Hydroxybenzaldehyde","Norecasantalic acid","5-Hydroxyindoleacetic acid","NSC54249","Benzofuran, 4,7-dimethyl-","Dicyclohexylamine","Cyclohexylamine","Laricitrin","Dihydro-4-mercapto-5-methyl-3(2H)-thiophenone","alpha-Hydroxy-1-methyl-1H-indole-3-propanoic acid","1,2,3-Trihydroxybenzene","Butyrylcarnitine","alpha-Methylstyrene","Mukoenine A","Guanosine monophosphate","Eugenyl benzoate","L-Theanine","2,3-Epoxyphylloquinone","N,N-Dimethylanthranilic acid","Prednisolone_Tebutate","Leucylleucine","Citronellyl anthranilate","Iminostilbene","Caffeic acid","4-aminobenzene-1,2-diol","LysoPC(18:0/0:0)","N,N'-Dibenzylethylenediamine","4-Methylstyrene","Proline betaine","Pyrazine","2-Hydroxy-5-methylquinone","N-Methyl-L-proline","5-Diazouracil","Viburtinal","Pantothenic acid","PC(20:5(5Z,8Z,11Z,14Z,17Z)/20:5(5Z,8Z,11Z,14Z,17Z))","Nookatone","4-Isopropylphenylacetaldehyde","1-Palmitoylphosphatidylcholine","(+)-4,11-Eudesmadien-3-one","Xanthurenic acid","Myricetin","DL-Proline","1,3-Benzodioxole","3-Methylxanthine","2-Propylfuran","Xanthyletin","3-Furoic acid","2-Hexenyl acetate","Indazole","4-Methoxybenzaldehyde","Amifostine","Alacepril","Diethyl carbonate","Sulfamethazine","1-Methylguanine","Diethylamine","3,5a,9-Trimethyl-3a,5,5a,9b-tetrahydronaphtho[1,2-b]furan-2,8(3H,4H)-dione","Leucomalachite green","3-Methyladenine","Isovalerylcarnitine","2-Hydroxyadenine","Indole","Indole-3-carbinol","Proline","N-Acetyl-Leu","Paramethadione","Ethylone","6-Acetyl-2,3-dihydro-2-(hydroxymethyl)-4(1H)-pyridinone","Gentisate aldehyde","DL-Arginine","Mesoxalonitrile","cis-Vitamin K1","Furanone A","Vitexin 6''-O-malonyl 2''-O-xyloside","N2, N2-Dimethylguanosine","1,2-Dichloroethane","Adenosine","Adenosine monophosphate","Inositol 1,4-diphosphate","Allopurinol","Indanone","Aromadendrin","Guanidoacetic acid","Oxyphenonium","2,3-Dihydro-4-methylfuran","Homogentisic acid","L-Tyrosine","6-Decanolide","1-Naphthylamine","1-Butanethiol","Alpinetin","Phenylpyruvic acid","3,5-Di-tert-butyl-4-hydroxybenzoic acid","Stearidonic acid","5-Methylcytosine","Alanyltryptophan","Triethylamine","2-Aminonaphthalene","(1R,4R)-p-Mentha-2,8-dien-1-ol","alpha-Ionene","3-[[(2S)-2,4-Dihydroxy-3,3-dimethylbutanoyl]amino]propanoic acid","Emodinanthranol","D-Glucose, 4-O-beta-D-galactopyranosyl-","N-Undecanoylglycine","9-HOTE","Octadeca-9,11-dienoic acid","Rose oxide","Propionylcarnitine","Dioctyl phthalate","4-hydroxymethylsalicylic acid","Luteolin 7-galactoside","Lysine","Acetaminophen","trans-Cinnamic acid","Trimethyloxazole","Phenylacetaldehyde","Benalfocin","Glutamic acid","(R)-Carvone","2-Methyl-1-propanethiol","2,3,4-Trihydroxybenzoic acid","Ethyl maltol","Guanine","Pyrimidine","Acridone","Levoglucosan","2-Naphthol","1-Methylnicotinamide","4-Methylumbelliferone","PS(18:0/18:2(9Z,12Z))","ETHADIONE","LPC(1-acyl 18:1)","cis-Caffeic acid","N,N-Dimethylacetamide","beta-aminoacrylic acid","Zilpaterol","DL-Theanine","1,1-Dimethylurea","Myricetin 3-galactoside","Pyridoxine","Ocimen quintoxide","4-Vinylpyridine","3,4-Diaminopyridine","Di-N-propylamine","1,4-Benzoquinone dioxime","7-Methylguanine","N,N-Dimethylformamide","S-Cysteinosuccinic acid","Docosanamide","3-Hydroxybenzyl alcohol","2-Isopropylphenol","Acepromazine","Palmitic amide","PS(18:1(9Z)/18:1(9Z))","(5Z,9Z,12Z)-octadeca-5,9,12-trienoic acid","Benzeneacetonitrile","2-Chloroethanol","Theobromine","Cycloserine","Glycocholic acid","4,4alpha,5,6-Tetrahydro-7-methyl-2(3H)-naphthalenone","Methyl cinnamate","Dieporeticanin","Indole-3-carboxaldehyde","8-Hydroxyadenine","alpha-Curcumene","2-Ethylpyrazine","4'-Isopropylacetophenone","beta-Mercaptoethanol","4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]butanoic acid","1H-Imidazole-1-acetic acid","1,3-Dihydro-(2H)-indol-2-one","Isobutyramide","Corymboside","Phenyl-Alanine","Tryptophol","Isoquinoline","2-Methyl-1-pyrroline","Rhodamine B","9,10-Epoxyoctadecenoic acid","1-Methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine","alpha-Methylene-gamma-butyrolactone","2-Aminoadipic acid","cis-3-Hexenyl isobutyrate","Thymol","Dodecanoic acid","Pyrimethanil","2-Ethyl-4-methyloxazole","Uridine 5'-diphosphate","Hydrocotarnine","18-Epiormosanine","Sphinganine","Diethyl sulfide","2,4-Dimethylquinoline","Panaxynol linoleate","2-Ethyl-5-methyloxazole","DG(16:0/0:0/18:4n3)","Vicenin 2","Oleoylethanolamide","Dimethyldisulfide","1-Methyladenosine","2-Methylimidazole","Baikiain","(2'E,4'Z,7'Z,8E)-Colnelenic acid","Maltol","Beta-Aminopropionitrile","PS(14:0/18:1(9Z))","MG(16:0/0:0/0:0)","Isonicotinic acid","Naringenin","Allantoin","1,2,3-tri-O-Galloyl-beta-4C1-glucose","Isoleucylproline","Methyl benzoate","2-Methylpyrrolidine","2-Hydroxybenzaldehyde","Osthol","Quercetin 3-galactoside","Nerolidol","4-Hydroxy-2-butenoic acid gamma-lactone","beta-Alanine","Kynurenic acid","Agmatine","4-Ethyl-2-methyloxazole","Trigonelline","Pyridoxal","5-Ethyl-4-methyloxazole","2,8-Quinolinediol","Palmitoylethanolamide","Ethyl isopropyl sulfide","Edetic Acid","4-Hydroxy-2,6,6-trimethyl-3-oxo-1,4-cyclohexadiene-1-carboxaldehyde","MAG (18:3)","2,6-Dimethylquinoline","Benzamidine","Styrene","ethylsulfenate","DL-Indole-3-lactic acid (3-Indolelactic acid)","7-Methylguanosine","4-Aminoisoxazolidin-3-one","1-Methylguanosine","(S)-Hexahydropyrrolo[1,2-a]pyrazine-1,4-dione","Pyrrole-2-carboxylic acid","Methyl 2-hydroxybenzoate","9,12-Octadecadiynoic acid","9-Pentadecenoic acid","Diisopropylamine","Chloromethyl methyl ether","Linoleamide","L-Norleucine","(2R)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one","L-Tryptophan","Methacrylamide","Niacinamide","Casticin","Kaempferol","4-Guanidinobutanoic acid","3-(Dimethylaminomethyl)indole","Tetraethylene glycol monododecyl ether","2,4,6-Octatriynoic acid","Morpholine","9,10-epoxy-10,12Z,15Z-octadecatrienoate","Crotamiton","Eicosadienoic acid","5-Hydroxymethyl-2-furancarboxaldehyde","1-Methyl-1,3-cyclohexadiene","Indole-3-propionic acid","trans-Cinnamyl alcohol","Niranthin","2-Hydroxyacetophenone","LysoPC(18:3(6Z,9Z,12Z)/0:0)","Isovitexin","Dicumyl peroxide","1-Butylamine","Aminocaproic acid","Creatine","5-Aminolevulinic acid","2-amino-5-(amino-dimethylamino-methylidene)amino-pentanoic acid","LysoPC(18:2/0:0)","Benzamidoxime","N2,N2-Dimethylguanosine","2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one","(E)-methyl ester 3-phenyl-2-propenoic acid","(±)-4-Methylene-2-pyrrolidinecarboxylic acid","Imidazolone","LysoPC(18:1/0:0)","Myristic acid","2-(Methylthio)propane","Paraxanthine","Hypoxanthine","(±)-erythro-Isoleucine","L-Arginine","Carveol","5-Aminoimidazole","Rocuronium","PC(16:0/18:3(9Z,12Z,15Z))","Alpha-Lactose","Miscanthoside","3-Methoxybenzaldehyde","Methyl stearate","Homovanillic acid","2-Methoxybenzaldehyde","N6,N6,N6-Trimethyl-L-lysine","5-Hydroxyindole","Nebivolol","(E)-1-Cinnamoylpyrrolidine","p-Octopamine","Catechin","(S)-5'-Deoxy-5'-(methylsulfinyl)adenosine","Tropine","Adenine","Choline sulfate","(-)-Nopol","2-Hydroxyphenethylamine","LysoPC(16:0/0:0)","Naphthalene-1,2-diol","Difructose anhydride III","D-Proline","alpha-Tocotrienol","4-(Dimethylamino)benzoic acid","L-Serine","N-Acetyl-2,3-dihydro-1H-pyrrole","Dimethylglycine","3-Methylguanine","D-Phenylalanine","3-Hydroxyphenylacetic acid","2-Pyrrolidinone","1,2-Dimethylimidazole","Emopamil","D-Histidine","2-Butanethiol","7-Methyl-2-benzofurancarboxaldehyde","(R)-(6-Methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanol","3,4-Dimethylbenzoic acid","Palmitic acid","Ethyl isothiocyanate","2-Carboxyarabinitol 5-phosphate","Histidine","muco-Inositol","2-(Methylamino)benzoic acid","Betazole","Dieporeticenin","4-Hydroxy-2H-pyran-3-carboxaldehyde","Caffeine","(-)-Abscisic acid","1,10-Phenanthroline","trans-3-Hexenyl acetate","Esculin","2-Methyl-1-propylamine","Butyramide","N-Acetylproline","Glyceryl monolinoleate","N-Vinyl-2-pyrrolidone","Procyanidin B2","PC(18:3(9Z,12Z,15Z)/18:3(9Z,12Z,15Z))","1,3,5-Triazine-2,4-diamine","Quercetin","Theaflavin","Agrocybin","Tetramethylpyrazine","Theophylline","Methyl phenylacetate","2-Hydroxy-4-methylbenzaldehyde","(2'E,4'Z,8E)-Colneleic acid","Nicotyrine","Lansiumamide B","Picolinic acid","keratan sulfate II (core 2-linked), degradation product 1","Sumiki's acid","Astragalin","Pyroglutamic acid","1,3,5-Trihydroxybenzene","Luteolin","D-Aspartic acid","2-Methylguanosine","sec-Butylamine","4-Hydroxydiphenylamine","ACMC-20a9mk","5-Acetyl-3,4-dihydro-2H-pyrrole","S-Adenosylmethionine","(-)-Epigallocatechin","Manidipine","3',4,4'-Trihydroxypulvinone","1-Cyclohexyl-4-(1,2-diphenylethyl)piperazine","Quinic acid","Nobiletin","1,4-Benzodioxin-2(3H)-one","Choline","(2E)-Decenoyl-ACP","Indane","Pseudoionone","D-Tyrosine","Dihydroferulic acid 4-O-sulfate","Dibutyl phthalate","Tolazoline","Nicotinic acid","Tanakamine","Diphenylamine","Orotic acid","Indole-3-acetamide","Indoline","Diethylenetriamine","Nandrolone","Malic acid","12,13-EpOME","Mercaptopurine","LysoPE(16:0/0:0)","7-Methylxanthine","(2R,3R)-2-Aminooctadecane-1,3-diol","N-Methylcalystegine C1","Pyrimethamine","m-Coumaric acid","2-Furoic acid","Phosphorylcholine","3-Methylindole","S-Adenosylhomocysteine","MCULE-8196692160","Histamine","Dimethyl sulfoxide","Diphenylcyclopropenone","L-Aspartic acid","Nonadecanoic acid","Tetradecylamine","Isonicotinamide","Ureidoglycolic Acid","D-Citrulline","9-Octadecenamide","Herniarin","Acridine","Phthalic anhydride","(+)-Epicatechin","1,3-Dicyclohexylurea","Soybean lecithin","1-(Methylthio)-propane","Jasmolone","2-Hexenyl butanoate","2,5-Dihydro-2,4,5-trimethylthiazole","beta-Myrcene","p-Aminobenzoic acid","Piperidine","Indole-7-carboxaldehyde","Diethyltoluamide","Quinoxaline","Isocoumarin","Monoelaidin","9-Arabinofuranosyladenine","Imidazoleacetic acid","5-Ethyl-2-methyloxazole","9-beta-d-Arabinofuranosylguanine","Lorlatinib","2-Methylfuran","dehydro-beta-Ionone","5-Hydroxy-L-tryptophan","(2R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one","Daidzein","1-Hydroxybenzotriazole"],"additional_accession":[]},"is_claimable":false,"name":"Mechanistic profiling of Bifemetstrobin against the tea anthracnose pathogen and candidate evaluation of an amine oxidase target","description":"Tea anthracnose caused by Glomerella cingulata threatens yield and quality, while resistance to legacy fungicides highlights the need for new modes of action. We characterized the antifungal activity and mechanism of bifemetstrobin against G. cingulata by combining efficacy assays with cell biology and integrated multi-omics. Bifemetstrobin inhibited mycelial growth (EC50 = 5.04 μg/mL) and spore germination and provided up to approximately 80% curative suppression on detached tea leaves. Microscopy revealed dose-dependent hyphal and conidial deformation and mitochondrial injury. Consistently, bifemetstrobin collapsed mitochondrial membrane potential (MMP), reduced intracellular ATP, and increased membrane leakage with depletion of reducing sugars and soluble proteins. Transcriptome, data-independent acquisition (DIA) proteomics and metabolome data converged on reprogramming of carbohydrate and amino-acid metabolism, membrane processes, and redox homeostasis, with DNA-replication signatures emerging at the higher dose. Cross-layer mapping prioritized an amine oxidase (AO) as a hub. Bifemetstrobin bound AO with micromolar affinity (microscale thermophoresis/isothermal titration calorimetry), supported by docking and molecular dynamics, and outperformed azoxystrobin in binding. Pairing bifemetstrobin with pyrrolnitrin yielded strong in vitro synergy and improved leaf protection. Across additional phytopathogens, bifemetstrobin retained activity in vitro (EC50 range 1.19–27.38 μg/mL), outperforming azoxystrobin on the tea anthracnose strain. These findings nominate AO as a high-confidence candidate supported by binding assays and link target engagement to mitochondrial failure and carbon-nitrogen reprogramming, supporting bifemetstrobin (alone or in rational mixtures) as a promising candidate for tea anthracnose management.","dates":{"publication":"2026-04-24","submission":"2026-04-24"},"accession":"MTBLS14357","cross_references":{"HMDB":["HMDB0002217","HMDB0001172","HMDB0254610","HMDB0000005","HMDB0000187","HMDB0000139","HMDB0000957","HMDB0256963","HMDB0247933","HMDB0252052","HMDB0000134","HMDB0000176","HMDB0000883","HMDB0039324","HMDB0000254","HMDB0004041","HMDB0033552","HMDB0001870","HMDB0031157","HMDB0031861","HMDB0303018","HMDB0041492","HMDB0042033","HMDB0031872","HMDB0029750","HMDB0059882","HMDB0036186","HMDB0033152","HMDB0000262","HMDB0061093","HMDB0002234","HMDB0062585","HMDB0015231","HMDB0001843","HMDB0001369","HMDB0059743","HMDB0000620","HMDB0000172","HMDB0000557","HMDB0245808","HMDB0251526","HMDB0000687","HMDB0304538","HMDB0000168","HMDB0000214","HMDB0003374","HMDB0000661","HMDB0031518","HMDB0341247","HMDB0251283","HMDB0033053","HMDB0000943","HMDB0001895","HMDB0032576","HMDB0000500","HMDB0002466","HMDB0061680","HMDB0000301","HMDB0059965","HMDB0031338","HMDB0062562","HMDB0001232","HMDB0037762","HMDB0032335","HMDB0001161","HMDB0000641","HMDB0000182","HMDB0000448","HMDB0003339","HMDB0247590","HMDB0031472","HMDB0000098","HMDB0040578","HMDB0062642","HMDB0000646","HMDB0000283","HMDB0001405","HMDB0012308","HMDB0001851","HMDB0013676","HMDB0258836","HMDB0013677","HMDB0001856","HMDB0037288","HMDB0340513","HMDB0000847","HMDB0001190","HMDB0000555","HMDB0031411","HMDB0000857","HMDB0029865","HMDB0014023","HMDB0000355","HMDB0002641","HMDB0002035","HMDB0030677","HMDB0000159","HMDB0030524","HMDB0000232","HMDB0246532","HMDB0006462","HMDB0015320","HMDB0033161","HMDB0029644","HMDB0000484","HMDB0060176","HMDB0060244","HMDB0029649","HMDB0005807","HMDB0000126","HMDB0032302","HMDB0000893","HMDB0031513","HMDB0013287","HMDB0003070","HMDB0242109","HMDB0003357","HMDB0254499","HMDB0000402","HMDB0012490","HMDB0030819","HMDB0029684","HMDB0003269","HMDB0000707","HMDB0030007","HMDB0000211","HMDB0000765","HMDB0000107","HMDB0254590","HMDB0000807","HMDB0040205","HMDB0032448","HMDB0000947","HMDB0015496","HMDB0000784","HMDB0059767","HMDB0304554","HMDB0000193","HMDB0029048","HMDB0028768","HMDB0000094","HMDB0251388","HMDB0000565","HMDB0000625","HMDB0033836","HMDB0032440","HMDB0000792","HMDB0029457","HMDB0013679","HMDB0259357","HMDB0060013","HMDB0030396","HMDB0000512","HMDB0255056","HMDB0255446","HMDB0258301","HMDB0002123","HMDB0000639","HMDB0000663","HMDB0032211","HMDB0000888","HMDB0031736","HMDB0004620","HMDB0031823","HMDB0256929","HMDB0037606","HMDB0304087","HMDB0094660","HMDB0002056","HMDB0258934","HMDB0059729","HMDB0340663","HMDB0000933","HMDB0340316","HMDB0032548","HMDB0340315","HMDB0000623","HMDB0341301","HMDB0000273","HMDB0014737","HMDB0340322","HMDB0028867","HMDB0002327","HMDB0000296","HMDB0032822","HMDB0255052","HMDB0029355","HMDB0000727","HMDB0247297","HMDB0036619","HMDB0251705","HMDB0340336","HMDB0006330","HMDB0011719","HMDB0060055","HMDB0035214","HMDB0002124","HMDB0002259","HMDB0340347","HMDB0029943","HMDB0029631","HMDB0006294","HMDB0061658","HMDB0001316","HMDB0000279","HMDB0001388","HMDB0033375","HMDB0000133","HMDB0256899","HMDB0340360","HMDB0001871","HMDB0303676","HMDB0010203","HMDB0061755","HMDB0304751","HMDB0002899","HMDB0256581","HMDB0029620","HMDB0303943","HMDB0304749","HMDB0304505","HMDB0303099","HMDB0014948","HMDB0242602","HMDB0040520","HMDB0014511","HMDB0340389","HMDB0000782","HMDB0253260","HMDB0030835","HMDB0001227","HMDB0000288","HMDB0033581","HMDB0059915","HMDB0035919","HMDB0033648","HMDB0038728","HMDB0011649","HMDB0029681","HMDB0301710","HMDB0001058","HMDB0000944","HMDB0244434","HMDB0303040","HMDB0000258","HMDB0000975","HMDB0036895","HMDB0240477","HMDB0003164","HMDB0035022","HMDB0035698","HMDB0242127","HMDB0034278","HMDB0033637","HMDB0030564","HMDB0030975","HMDB0303056","HMDB0249519","HMDB0037340","HMDB0256451","HMDB0036634","HMDB0037944","HMDB0029255","HMDB0035588","HMDB0256030","HMDB0003153","HMDB0301673","HMDB0302380","HMDB0037362","HMDB0037932","HMDB0301926","HMDB0011628","HMDB0034683","HMDB0030273","HMDB0302971","HMDB0011508","HMDB0011507","HMDB0011506","HMDB0303631","HMDB0039179","HMDB0242118","HMDB0037971","HMDB0253399","HMDB0003213","HMDB0029280","HMDB0033288","HMDB0251621","HMDB0039321","HMDB0038820","HMDB0002927","HMDB0037574","HMDB0301686","HMDB0003249","HMDB0038287","HMDB0037539","HMDB0031457","HMDB0114836","HMDB0007860","HMDB0114982","HMDB0114983","HMDB0114955","HMDB0114954","HMDB0114902","HMDB0010585","HMDB0006112","HMDB0009125","HMDB0009093","HMDB0255861","HMDB0255179","HMDB0060428","HMDB0031419","HMDB0031229","HMDB0006458","HMDB0000237","HMDB0003453","HMDB0244173","HMDB0031523","HMDB0252861","HMDB0003052","HMDB0062472","HMDB0254670","HMDB0006961","HMDB0010591","HMDB0010675","HMDB0010616","HMDB0010645","HMDB0010588","HMDB0244000","HMDB0041357","HMDB0038768","HMDB0037936","HMDB0033499","HMDB0030414","HMDB0002367","HMDB0040184","HMDB0034533","HMDB0013488","HMDB0013472","HMDB0013476","HMDB0258600","HMDB0116605","HMDB0062676","HMDB0252067","HMDB0250123","HMDB0000243","HMDB0030661","HMDB0002329","HMDB0000161"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