Following database searching and metabolite annotation, the overall quality of metabolomics raw data was evaluated. In metabolomics research, the quality of mass spectrometry raw data is mainly assessed from three perspectives:
Reproducibility of QC samplesQuality control (QC) samples were prepared by pooling all test samples in equal proportions prior to LC-MS analysis. To assess errors derived from mass spectral signal drift, a QC sample was inserted at regular intervals throughout the batch analysis. High reproducibility among QC samples indicates good instrumental stability. The reproducibility of QC samples was evaluated via PCA plots and QC correlation plots. A correlation coefficient greater than 0.8 was considered to indicate reliable instrument stability.
Intra-group sample reproducibilityIntra-group reproducibility reflects the stability of biological replicates. Generally, good intra-group consistency ensures more reliable identification of differential metabolites and better predictive performance of subsequent statistical models. Intra-group reproducibility was judged by the clustering degree of biological replicates in PCA plots and the correlation coefficients in sample correlation analysis. However, this criterion is only for reference, owing to the unstable abundance of metabolites, easy degradation of certain compounds, and large individual biological variation.
Inter-group sample differentiationAccording to the experimental grouping, PCA and correlation analysis were used to evaluate the degree of inter-group differences. Typically, clearer group separation in PCA and lower inter-group correlation coefficients suggest more distinct biological differentiation, which further results in a higher proportion of differential metabolites among all annotated metabolites. This evaluation criterion is greatly influenced by sample type and experimental design.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - negative - reverse-phase","Liquid Chromatography MS - positive - reverse-phase"],"chromatography_protocol":["The liquid chromatography-tandem mass spectrometry (LC-MS/MS) system for metabolomic analysis consists of a Waters Acquity I-Class PLUS ultra-high performance liquid chromatograph coupled with a Waters Xevo G2-XS QTOF high-resolution mass spectrometer. The analytical column used was an Acquity UPLC HSS T3 column (1.8 μm, 2.1 mm × 100 mm) purchased from Waters [3].
Positive ion mode (POS):Mobile phase A: 0.1% formic acid in water;Mobile phase B: 0.1% formic acid in acetonitrile.
Negative ion mode (NEG):Mobile phase A: 0.1% formic acid in water;Mobile phase B: 0.1% formic acid in acetonitrile.
The injection volume was 2 μL
"],"publication":["XMulti-omics reveals zearalenone-induced hepato-intestinal injury and growth dysregulation in largemouth bass (Micropterus salmoides)."],"submitter_affiliation":["Zhejiang Sci-Tech University"],"submitter_name":["Chenming Lei"],"organism_part":["liver"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["Solid sample:
(1) Weigh 50 mg of the sample, add 1000 μL of internal standard-containing extraction solution (methanol:acetonitrile:water = 2:2:1, v/v/v; internal standard concentration: 20 mg/L), and vortex for 30 s to mix thoroughly.
(2) Add steel balls, homogenize with a tissue grinder at 45 Hz for 10 min, then perform ice-bath ultrasonication for 10 min.
"],"organism":["Largemouth bass"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS14430"],"author":["Chenming Lei. Zhejiang Sci-Tech University. College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China. lcm2001916111@163.com."],"data_transformation_protocol":["Raw data acquired by MassLynx V4.2 were processed using Progenesis QI for peak picking, peak alignment and other data pretreatment procedures. Metabolite identification was performed based on the online METLIN database embedded in Progenesis QI, public databases, and the internal self-built database of Biomarker Technologies, with simultaneous recognition of theoretical fragment ions
"],"study_factor":["Zearalenone"],"submitter_email":["lcm2001916111@163.com"],"sample_collection_protocol":["Largemouth bass (initial body weight 2.82 ± 0.09 g) were purchased from Foshan Huopo Aquatic Breeding Co., Ltd (Guangdong, China). A total of 600 juvenile fish were randomly allocated to three groups, namely the control (Con), LZ and HZ groups, with five replicate tanks per group (40 fish per replicate, and each tank contained 450 L of water). The juvenile fish were fed to apparent satiation twice daily at 08:30 and 17:30, respectively. During the 28-day subchronic exposure period, key water quality parameters were monitored and maintained at the target ranges: water temperature at 24.0 ± 2.0 °C, pH at 7.6–8.0, dissolved oxygen above 6.0 mg/L, total ammonia nitrogen below 0.4 mg/L. Following the 28-day feeding trial, juveniles were fasted for 24 h and then anesthetized with tricaine methanesulfonate (MS-222, 50 mg/L). All surviving fish were collected to determine final body weight (FBW), which was subsequently used to calculate growth-related indices including weight gain rate (WGR), specific growth rate (SGR), condition factor (CF), and hepatosomatic index (HSI), along with feed efficiency-related indices including the feed intake (FI), feed conversion ratio (FCR) (see formulae in Table S1). Immediately after dissection, liver and midgut samples (5 samples per group) were fixed in 10% neutral buffered formalin for histological assessment. Whole blood (5 samples per group) was collected from the caudal vein using EDTA-coated tubes and stored at 4℃ for subsequent immune-related enzyme activity assays. Hepatic tissues (sourced from the same fish used for immune-related enzyme activity assays) were homogenized in ice-cold 0.9% physiological saline (1:9, w/v) to prepare tissue homogenates for antioxidant capacity determination. Furthermore, midgut tissues (derived from the fish used for immune-related enzyme activity assays) were preserved in RNAlater™ (Thermo Fisher Scientific, Waltham, MA, USA) at 4 °C for subsequent qRT-PCR analysis and the quantification of intestinal epithelial tight junction protein levels, while the residual intestinal contents were snap-frozen in liquid nitrogen and stored at −80 °C for microbiome and metabolome profiling.
"],"omics_type":["Metabolomics"],"study_design":["Metabolomics","Waters ACQUITY UPLC I-Class PLUS System","Waters Xevo G2-XS QTof","liver","untargeted analysis","Zearalenone","pooled sample","largemouth bass","untargeted metabolite profiling","experimental sample"],"curator_keywords":["Metabolomics","Waters ACQUITY UPLC I-Class PLUS System","Waters Xevo G2-XS QTof","liver","untargeted analysis","Zearalenone","pooled sample","largemouth bass","untargeted metabolite profiling","experimental sample"],"mass_spectrometry_protocol":["The Waters Xevo G2-XS QTof high-resolution mass spectrometer was operated in the MSe mode under the control of the acquisition software (MassLynx V4.2, Waters) for the acquisition of primary and secondary mass spectral data. In each data acquisition cycle, dual-channel data acquisition can be performed at low and high collision energies simultaneously. The low collision energy was set to off, and the high collision energy ramp ranged from 10 to 40 V with a scan rate of 0.2 s per spectrum. The parameters of the ESI ion source were set as follows [3]:
(1) Capillary voltage: 2500 V (positive ion mode) or −2000 V (negative ion mode);(2) Cone voltage: 30 V;(3) Ion source temperature: 100 ℃;(4) Desolvation gas temperature: 500 ℃;(5) Cone gas flow rate: 50 L/h;(6) Desolvation gas flow rate: 800 L/h;(7) Mass-to-charge ratio (m/z) acquisition range: 50–1200
"],"metabolite_name":["TRYPTOPHAN ETHYL ESTER","Plantagonine","p-Mentha-1,3,5,8-tetraene","2',4',5'-Trihydroxybutyrophenone","2',3'-Cyclic UMP","MG(0:0/18:1(11Z)/0:0)","indole-3-acetyl-tyrosine","Dacarbazine","Ectoine","PE(22:0/20:4(5Z,8Z,11Z,14Z)-OH(20))","Ethoxybenzyl diethylenetriamine","N-Valerylglycine methyl ester","Aypgkf","Prostaglandin H1","1,2,3,4,5,6-Hexahydro-5-(1-hydroxyethylidene)-7H-cyclopenta[b]pyridin-7-one","Prostaglandin H2","1-Monostearin","Cyclooctatin","20alpha-Hydroxycholesterol","Matsutakeside I","N-[3-hydroxy-1-{[3.4.5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}octadec-4-en-2-yl]hexadecanamide","Methanofuran","(2R)-O-Phospho-3-sulfolactate","3-Methylthiopropyl-desulfoglucosinolate","PG(16:0/20:3(5Z,8Z,11Z))","CDP-DG(a-21:0/18:1(12Z)-O(9S,10R))","Kinetensin 4-7","2-Methyl-1-Pyrroline","N-[1-{[3.4-dihydroxy-6-(hydroxymethyl)-5-{[3.4.5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-3-hydroxyoctadec-4-en-2-yl]tetracosanamide","Limonexic acid","Melilotussaponin O1","Hovenolactone","NCGC00347620-02_C22H34O4_7-Oxabicyclo[4.1.0]hept-3-ene-2,5-diol, 4-(hydroxymethyl)-1-[(1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl-1-naphthalenyl)methyl]-","1-Methyl-1,2,3,4-tetrahydroisoquinoline","(6R,8Z)-6-Hydroxy-3-oxotetradecenoic acid","5b-Cholestane-3a,7a,12a,23S,25-pentol","1-(1,3-Benzodioxol-5-ylcarbonyl)piperidine","Sarmentosin","4,6-Dihydroxy-2-mercaptopyrimidine","Northienamycin","Norcocaine","6-Methylquinoline","Digitoxigenin bisdigitoxide","alpha-Fluoro-beta-alanine","Lamivudine","L-phenylalanyl-L-proline","PC(24:1(15Z)/24:1(15Z))","23S,25,26-Trihydroxyvitamin D3","dTDP-D-mycaminose","(1R,6R)-6-Hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate","Thromboxane","1-[2-Methyl-3-(methylthio) allyl]cyclohex-2-enol","6''-O-Carbamoylkanamycin A","PC(18:1(9E)/0:0)[U]","Gualenate (Sodium Gualenate)","Hydroxyprolyl-Lysine","Prostaglandin C2","(+)-4,11-Eudesmadien-3-one","1,3-Diisopropylbenzene","Avadomide","(2S,2'S)-Pyrosaccharopine","2-(4-Methylphenyl)propanal","Diplodiatoxin","Estradiol-17beta","2-Methylpiperidine","hexadecan-6Z,11Z-dien-1-ol","7,10-Hexadecadiynoic acid","dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose","Gentamicin B","Proteacin","PC(P-16:0/PGE1)","N-Docosahexaenoyl GABA","PC(22:5(4Z,7Z,10Z,13Z,16Z)/PGE2)","PG(i-12:0/a-17:0)","Androsterone glucuronide","n,n',n''-triacetyl-chitotriose","7-Hydroxy-2,5-dimethyl-4H-1-benzopyran-4-one","Prostaglandin A2","beta-Ionone","3-epi-6-Deoxocathasterone","PA(16:0/0:0)[cyclic]","Leu Glu Thr","Dihydroactinidiolide","ent-16b,19-Kauranediol 19-acetate","Isoleucyl-Leucine","Citrusin III","Eflornithine","Desglucocoroloside","curcumin 4'-O-beta-D-gentiobiosyl 4''-O-beta-D-glucoside","Glutathione episulfonium ion","Oleanolic acid","Propanoyl phosphate","Sphingosine","3b,12a-Dihydroxy-5a-cholanoic acid","Methionyl-Cysteine","7',8'-Dihydro-8'-hydroxyreticulataxanthin","D-Fructose 1,6-bisphosphate","sn-Glycero-3-phosphoethanolamine","4-Carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate","12-Methyltridecanal","Botryodiplodin","(E)-octadec-9-en-12-ynoic acid","N-Undecanoylglycine","Carbamazepine-o-quinone","Bestatin","20alpha,22beta-Dihydroxycholesterol","Oblongolide","PC(16:0/O-1:0)[U]","5-(3,4-Dimethyl-5-pentylfuran-2-yl)pentanoylcarnitine","2-Methylcyclododecanone","Angiotensin (5-7)","S-(2-Hydroxyethyl)glutathione","(E)-2-Octen-1-ol","Phenylacetaldehyde","D-pipecolate","9Z,12Z-Octadecadienal","Ala-Thr-Trp-Leu-Pro-Pro-Arg","Erythrono-1,4-lactone","Fosetyl","Herculin","Descladinose roxithromycin","Tyrosyl-Valine","Ibuprofen glucuronide","Fructoselysine","Bursin","3-Carbamyl-(3'-picolyl)-4-methoxy-1-benzamide","Paroxetine","2,2,6,7-Tetramethylbicyclo[4.3.0]nona-1(9),4-dien-8-one","Petroselinic acid","C16 Sphinganine","Halovir A","Methylajoene","Safynol","Mycarose","1-(2-Furanyl)-2-propanone","1-O-Octadec-9-enyl glycerol","Monomethyl phthalate","2-Thiocytidine","Evobioside","(3Z)-Phytochromobilin","5,6-Dihydrouridine","Maleamic acid","2-(1-Pentenyl)furan","Benzeneacetonitrile","Tyr Leu","p-cresol","7-Hydroxybutylidenephthalide 7-(6-malonylglucoside)","(1(10)E,4E,6a,8b)-8-Angeloyloxy-14-oxo-1(10),4,11(13)-germacratrien-12,6-olide","2-Chloro-L-phenylalanine","SN38 glucuronide","DL-Valine-4-antipyrineamide","N,N'-Dicyclohexylurea","3-Methylethcathinone","N-[4-(Benzylamino)-3-cyanoquinolin-2-yl]-4-methoxybenzamide","1,25-Dihydroxy-16-ene-23-yne-vitamin D3","2-(Fluoromethyl)-3-(3,4-dihydroxyphenyl)alanine","4-Fluoro-L-threonine","Psilostachyin","Abscisic acid glucose ester","Dihydroclavaminic acid","(23R)-Acetoxytomatine","val-leu-pro-val-pro-gln","Rumenic acid","Thyrotropin releasing hormone","7alpha-Hydroxycholesterol","MG(0:0/22:4(7Z,10Z,13Z,16Z)/0:0)","Hydroxy-gamma-sanshool","PS(16_0_20_4(5Z,8Z,11Z,14Z))","H Type II trisaccharide","Repinotan","THYMOPENTIN","1-(2-Furanyl)-1-propanone","Aquifoliunine EII","Butyryl-L-carnitine","Ornithylamphotericin methyl ester","Physostigmine","2-Octenoic acid","Milbemycin A4","Boceprevir","lythramine","Methyl dioxindole-3-acetate","Maltol","L,L-Cyclo(leucylprolyl)","1alpha,3beta,22R-Trihydroxyergosta-5,24E-dien-26-oic acid 3-O-b-D-glucoside 26-O-[b-D-glucosyl-(1->4)-6-acetyl-b-D-glucosyl-(1->2)-6-acetyl-b-D-glucosyl] ester","Nebramycin 5","PGD2 ethanolamide","Janthitrem C","Janthitrem B","Styrene-cis-2,3-dihydrodiol","Isoleucylproline","2,12-Tetradecadiene-4,6,8,10-tetrayne","Surfactin D","Talinumoside I","8-Amino-7-oxononanoic acid","1-(Methylthio)-1-hexanethiol","Trp Leu","Falcarindiol","Avocadenofuran","Ubiquinone-6","PE(22:1(13Z)/LTE4)","Mergepta","Soquinolol","3-(Acetyloxy)-2-hydroxypropyl octadecanoate","6-(alpha-D-Glucosaminyl)-1D-myo-inositol","Calcitriol","Licorice glycoside A","5-Hexyltetrahydro-2-oxo-3-furancarboxylic acid","MG(0_0_20_4(5Z,8Z,11Z,14Z)_0_0)","Nordihydroguaiaretic Acid","MG(0:0/22:5(4Z,7Z,10Z,13Z,16Z)/0:0)","3a,7a,12a-Trihydroxy-5b-cholestan-26-al","2-Propyl-2,4-pentadienoic acid","Chenodeoxycholylcitrulline","Dopamine","Sucrose 1',4'-(4,4'-dihydroxy-3,3'-dimethoxy-b-truxinate)","Dihydrolipoate","Lurbinectedin","Desmethylondansetron","Biotin sulfone","INOSINE 5'-MONOPHOSPHATE","xi-3-(4-Isopropylphenyl)-2-methylpropanal","Pantothenate","6-Kestose","alpha-Vetivone","Methyl fluoroquinolone","Cinnamaldehyde","Cuminaldehyde","2-Pentadecylfuran","Calamusenone","Unknown 370","2-Hydroxybiphenyl","gly-arg","Oxandrolone","Apigenin 6-C-arabinosyl-8-C-glucoside","(2xi,4xi)-2,4-Nonadien-1-ol","Cassiaside C","CDP-4-dehydro-3,6-dideoxy-D-glucose","Allotetrahydrodeoxycorticosterone","2-Phenylaminoadenosine","PC(18:4(6Z,9Z,12Z,15Z)/0:0)","N-Eicosapentaenoyl Tyrosine","2-Methoxy-1,4-benzoquinone","PG(16:0/18:1(12Z)-2OH(9,10))","PC(P-18:1(11Z)/PGJ2)","6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1b'' aglycone","Gentamicin C1a","Acetylvalerenolic acid","Methymycin","DG(16:0/18:1(11Z)/0:0)","gamma-Glutamyl-gamma-aminobutyraldehyde","1,2-Benzisoxazole","2,6-Pipecoloxylidide","Miglustat","p-Coumaroylagmatine","D-Glucosaminate-6-phosphate","3,5,7-Trimethyl-2E,4E,6E,8E-decatetraene","Salannin","Inecalcitol","Undecylenic acid","Hyoscyamine","Crepenynate","Pectachol","Bioside","3-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione","alpha-Amylcinnamyl formate","4-Methyl-1-phenyl-2-pentanol","16,16-dimethyl-PGA1","Thymidine glycol","1-(11Z-docosenoyl)-glycero-3-phosphate","sphingosine (d17-1)","5Z,13Z-Docosadienoic acid","Rizatriptan","Cyclic ADP-ribose","Tulathromycin A","Daumone","5-O-beta-D-Mycaminosyltylactone","Biliverdin-IX-delta","4,5-octadienoylglycine","Carrageenan, potassium salt of","2-Methylbutylamine","GDP","Sanfetrinem","2,4-Diaminobutyric acid","3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane","Stearamide","a-L-Arabinofuranosyl-(1->3)-[a-L-arabinofuranosyl-(1r5)]-L-arabinose","1,2-Dihydro-1,1,6-trimethylnaphthalene","Elocalcitol","(2R)-N-[(2S)-1-[[(2S)-5-(Diaminomethylideneamino)-1-(heptylamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide","Premazepam","9-HydroxyNonadecanoylcarnitine","thiazolinedione","L-alpha-Acetyl-N-normethadol","Uroporphyrin IV","(+-)-Carbovir","Prometryn","Paratocarpin G","6-Amino-N-[6-keto-6-(6-ketohexylamino)hexyl]hexanamide","(E)-2-Butenyl-4-methyl-threonine","GlcNAcMan3GlcNAc2-I","3'-O-methyluridine","DG(20_0_14_0_0_0)","8-Deoxy-11,13-dihydroxygrosheimin","His Gly Gly","Oxymesterone","3-Ethyltoluene","alpha-Amylcinnamyl acetate","N-Desmethylrosuvastatin","δ-Tridecalactone","7-Mercaptoheptanoic acid","L-Pyrrolysine","Ethyl 2,4-dioxohexanoate","Choline","Tetrahydro-2-furanmethanol","Polyglycerol esters of fatty acids","PC(22_4(7Z,10Z,13Z,16Z)_P-18_0)","Liriodendrin","Ethyl N2-acetyl-L-argininate","N-Vinylpyrrolidine","quinoneimine","L-Isoleucine","N-Acetyl-N-[(2S)-3-(1H-indol-3-yl)-2-[[2-(4-piperidin-1-ylpiperidin-1-yl)acetyl]amino]propyl]-2-methoxybenzamide","Levanbiose","AB-MECA","Prenol","6-Oxopiperidine-2-carboxylic acid","C20916","(S)-Chiral alcohol","(-)-Epigallocatechin 3-p-coumaroate","Eremopetasinorone A","2-(6-hydroxyhexyl)-3-methylidenebutanedioic acid","2,4(1H,3H)-Pyridinedione","Geranylhydroquinone","1-Methylpyrrolinium","Fasoracetam","LysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)","Ulinastatin","Fumiquinazoline F-indoline-2',3'-diol","isopropyl unoprostone","3'-Hydroxystanozolol","7alpha-Hydroxy-3-oxo-4-cholestenoate","(2R,3R)-3-Methylornithinyl-N6-lysine","3-(4-Hydroxyphenyl)-1-propanol","Colistin","(1alpha,4beta,5beta)-4-Hydroxy-7(11),10(14)-guaiadien-8-one","Pedein B","Cerebronic acid","Narbomycin","lpe(0-0_20-4)","Mdpbp","3-Hydroxybutyrylcarnitine","PA(22:5(4Z,7Z,10Z,13Z,16Z)/20:3(6,8,11)-OH(5))","3-Oxooctanoic acid","Maltoheptaose","Threonylvaline","Gypsogenin 3-O-b-D-glucuronide","Casokefamide","3,4-Dihydroxyphenylacetaldehyde","Phenylgalactoside","2,4,6,8,10-dodecapentaenal","1-Palmitoyl-sn-glycero-3-phosphocholine","3beta-Hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-4alpha-carboxylate","Dethiobiotin","2-Acetyl-1,5,6,7-tetrahydro-6-hydroxy-7-(hydroxymethyl)-4H-azepine-4-one","2'-O-methylguanosine","Stemmadenine","2-Aminoethylphosphocholate","beta-D-Gentiobiosyl crocetin","Cyclopropanecarboxylic acid","Lefamulin","2-Cyclotetradecen-1-one","LysoPC(20:2(11Z,14Z))","LysoPC(18:3(9Z,12Z,15Z)/0:0)","D-1-[(3-Carboxypropyl)amino]-1-deoxyfructose","3-Isovalidene-3alpha,4-dihydrophthalide","(5Z,7E,9E,14Z,17Z)-Icosapentaenoate","Benzyladenine 3-O-beta-D-glucoside","Melatonin glucuronide","N-Acetyl-leu-leu-leu-tyr-amide","Osmundalin","4-Guanidinobutanoate","Cysteine sulfinate","Oenanthoside A","Porrigenin A","2-Methylbenzoic acid","CDP-DG(PGF1alpha/20:4(5Z,8Z,11Z,14Z))","Prostaglandin E2 methyl ester","Polyoxyethylene 40 monostearate","Hercynine","PA(22:4(7Z,10Z,13Z,16Z)/LTE4)","Pentahomomethionine","Flurithromycin","2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide","5-Acetamidopentanoate","4alpha-Carboxy-stigmasta-7,24(24(1))-dien-3beta-ol","2,2,6,6-Tetramethyl-4-piperidinol","n-arachidonylethanolamine","Kainic Acid","Dinitrophenyl-lysine","4-Methylaminobutanal","Oleic acid","MG(0:0/22:5(7Z,10Z,13Z,16Z,19Z)/0:0)","Bismahanine","Dicyclomine","Arg Gly Val","Eugenyl benzoate","meso-Tartaric acid","Lys Gly","4-Hydroxy-6-methyl-3-(1-oxobutyl)-2H-pyran-2-one","DMPO","Galactocerebroside","3',5'-Dideoxythymidine","1-Palmitoyl Lysophosphatidic Acid","Linatine","Tiglylcarnitine","8-Amino-8-demethylriboflavin 5'-phosphate","PE(16:0/0:0)","Octocrylene","3-Hydroxyhexadecanoylcarnitine","prostaglandin a1 ethyl ester","17-Hydroxymethylethisterone","2-(2-Furanyl)-3,4,5,6-tetrahydropyridine","Isovaleric acid","Carboxyfentanyl","Tetradecanol","Threoninyl-Lysine","Amphibine B","DG(20_5(5Z,8Z,11Z,14Z,17Z)_18_1(11Z)_0_0)","1,8-Dihydroxy-3-methylnaphthalene","Helenalin","15-HEPE","(-)-α-Cedrene","12(S)-HPETE","7alpha,27-Dihydroxycholesterol","2,3-Dihydro-6-methyl-5-propanoyl-1H-pyrrolizine","Pregnanolone","Acetyljujuboside B","DEACETYLGEDUNIN","Ne-Methyl-L-lysine","Andersoline","Norbicycloekasantalal","2-epi-5-epi-Valiolone","DG(i-14:0/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15)/0:0)","Pentadecanal","Murolic acid","exo-2-Methyl-3-methylenebicyclo[2.2.1]heptan-2-ol","11,12-Dimethoxy-8,11,13-abietatrien-20,7-olide","3,5-Dimethylpyrazole","3-Methylcyclohexanol","C16 Sphingosine","Delmopinol","Dihydroceramide C2","1,10-dihydro-1,10-dihydroxyfluoren-9-one","Isoketocamphoric acid","Perulactone","Mycosporine serinol","dTDP-L-olivose","Bupivacaine","n-methyl-2-(4'-methylaminophenyl)-6-hydroxybenzothiazole","Glutarylcarnitine","Tryptophyl-Tryptophan","hexanoylcarnitine","Angiotensin II","Glycochenodeoxycholate","2,3,6-Trimethylphenol","PELLETIERINE","8E,10E-Tetradecadienal","2-Amino-4-oxo-6-(1',2'-dioxoprolyl)-7,8-dihydroxypteridine","Tetracosahexaenoic acid, n-3","Dexanabinol","9-peroxy-5Z,7E,11Z,14Z-eicosatetraenoate","Cycloheximide","Acetylcarnitine","Oxepin","Acoric acid","Brivanib alaninate","Lentialexin","6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1a'' aglycone","Triethylamine","lpc(0-0_22-6)","11'-Carboxy-gamma-chromanol","Arginyl-Gamma-glutamate","Asparagoside A","9-cis-retinal","3,4,5-trihydroxy-6-{3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenoxy}oxane-2-carboxylic acid","3,6,8-Trimethylallantoin","Hydroxypentobarbital","Folinic acid","Spectinomycin","Isopentenyladenosine-5'-diphosphate","9,10-Epoxy-18-hydroxystearate","Emindole SB","1-Acetoxy-2-hydroxy-5,12,15-heneicosatrien-4-one","UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-glucose","3'-N-Debenzoyltaxol","3E,4Z,7,11-Tetramethyl-6,10-tridecadienal","L-Cyclopentylglycine","β-nonylenic acid","3,3'-Di-tert-butyl-5,5'-dimethoxybiphenyl-2,2'-diol","N-Methyl-1-deoxynojirimycin","PA(10:0/20:5(5Z,8Z,11Z,14Z,16E)-OH(18R))","Semilepidinoside B","monophospho-n-acetylneuraminic acid","Palustradienal","Cyclooctyne","3-Phenyl-2-propenyl","1-Linoleoylglycerophosphocholine","5b-Cholestane-3a,7a,12a,23-Tetrol","Norpandamarilactonine A","Oleandrin","Cyclolinopeptide A","Cyclolinopeptide B","MG(0:0/16:0/0:0)","Desacetylvinblastine","Preisocalamendiol","N-(2-Hydroxypropyl)valine","2-Thiohydantoin","N-stearoyl serine","LysoPE(20:3(5Z,8Z,11Z)/0:0)","PG(22:5(4Z,7Z,10Z,13Z,16Z)/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15))","xi-4-Hydroxy-4-methyl-2-cyclohexen-1-one","Dopamine quinone","Asp Val His Arg","4,4alpha,5,6-Tetrahydro-7-methyl-2(3H)-naphthalenone","Zeinoxanthin","4-Octylphenol","Tetraazacyclododecanetetraacetic acid","Betaine","(E,E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl propionate","Tyrosyl-Lysine","Formylfusarochromanone","N-Acetyl-O-demethylpuromycin-5'-phosphate","S-(9-hydroxy-PGA2)-glutathione","3-Methyl-1-phenyl-3-pentanol","(S,E)-2-(5-Hydroxy-8,9-dihydro-5H-benzo[7]annulen-6(7H)-ylidene)acetic acid","N(alpha)-Acetyl-L-2,4-diaminobutyrate","1-Heptanol","3-Methylbutan-1-ol","(10R,13R,17R)-3-Hexadecoxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene","2-acetyl-1,4,5,6-tetrahydropyridine","3-Quinolinecarboxylic acid, 7-((3R)-3-(1-aminocyclopropyl)-1-pyrrolidinyl)-1-((1R,2S)-2-fluorocyclopropyl)-1,4-dihydro-8-methoxy-4-oxo-","Phorbol myristate","3-Dehydro-2-deoxyecdysone","Isoquinoline","6-Deoxocathasterone","Homostachydrine","Digitoxigenin 3-[glucosyl-(1->6)-glucosyl-(1->4)-2,6-dideoxyribohexoside]","Avermectin B1b monosaccharide","Ketorolac","Santene","LYNESTRENOL","Misoprostol","(S)-gamma-Calacorene","4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol","Asparaginyl-Leucine","PC(22:5(4Z,7Z,10Z,13Z,16Z)/24:0)","Rutacridone","Glutamyl-S-allylcysteine","Pegorgotein","7Z-Octadecen-11-one","Erythromycin B","Erythromycin D","ARECOLINE","3-[(2-Benzyl-3-sulfanylpropanoyl)amino]propanoic acid","Estriol 3-sulfate 16-glucuronide","a-L-Arabinofuranosyl-(1->3)-b-D-xylopyranosyl-(1->4)-D-xylose","7-Hydroxy-2',5,6-trimethoxy-4',5'-methylenedioxyisoflavone 7-(2-p-coumaroylglucoside)","1-Oleoyl-sn-glycero-3-phospho-D-myo-inositol(1-)","His Tyr Gln Thr","[(2S,3R)-2-Amino-3-hydroxybutanoyl] (2S)-pyrrolidine-2-carboxylate","beta-Solanine","trans,trans-Farnesyl phosphate","Norcotinine","7-O-Demethyl Rapamycin","5-Hydroxyindolepyruvate","Fusarin C","Jubanine A","Bisacumol","Netilmicin","Dapdiamide B","2E,4Z-Octadienal","Cohibin A","LysoPC(22:4(7Z,10Z,13Z,16Z)/0:0)","Styrene","Cortisol 21-acetate","3-Hydroxy-4,6-heptadiyne-1-yl 1-glucoside","3-Hydroxyhexadecadienoylcarnitine","PE-NMe2(22:5(4Z,7Z,10Z,13Z,16Z)/24:1(15Z))","1-Nonadecanoyl-glycero-3-phosphoserine","5-Oxoavermectin ''1a'' aglycone","D-Glutamine","4-Hydroxyphenylglyoxylate","Withaperuvin D","6''-O-Caffeoylastragalin","Vigabatrin","3-oxostearic acid","N-Arachidonoyl Glutamic acid","1',2'-Dihydro-1,1'-dimethyl-2'-oxo-4,4'-bipyridinium(1+)","CDP-DG(i-20:0/PGF1alpha)","S-Formylglutathione","(R)-4'-Phosphopantothenoyl-L-cysteine","3-Methyl sulfolene","Bakuchiol","Retigabine","3-Hydroxyheptadecanoylcarnitine","Macrophorin D","(Z)-[(4-hydroxyphenyl)acetaldehyde oxime]","Hydrocinchonine","DG(21:0/LTE4/0:0)","Neocuscutoside C","3,4-Dimethyl-5-propyl-2-furanpentadecanoic acid","Leucylproline","1-Methyl-1,3-cyclohexadiene","PG(22:5(4Z,7Z,10Z,13Z,16Z)/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4))","Galabiosylceramide (d18:1/24:1(15Z))","cis-3,4-Leucopelargonidin","N-Acetylisoputreanine","Bucolome","Desmethyl rizatriptan","2-n-Propylthiazolidine-4-carboxylic acid","LysoPC(18:3(6Z,9Z,12Z)/0:0)","phenylethylamide 331","1-Phenyl-1-cyclohexene","11Z-Eicosenoic acid","pe(22-6(4z,7z,10z,13z,16z,19z)_p-16-0)","o-Xylene","Pentadecylamine","O-(13-Carboxytridecanoyl)carnitine","Isoleucylhydroxyproline","Aciclovir","tetraethylene-glycol","(-)-3-Carene","3-Hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoyl-CoA","PE(P-16:0/18:3(10,12,15)-OH(9))","LysoPE(0:0/18:3(6Z,9Z,12Z))","MG(0:0/22:0/0:0)","Hydroxyamobarbital","Himbacine","9-methanesulfinylnonanoic acid","(1(10)E,4a,5E)-1(10),5-Germacradiene-12-acetoxy-4,11-diol","Myristic acid","2-Phenylethanol","Octopamine (p-Hydroxyphenylethanolamine)","DG(16:0/18:2(9Z,12Z)/0:0)","3,11,12-Trihydroxy-1(10)-spirovetiven-2-one","2,2,4,4,6,6-Hexamethyl-1,3,5-trithiane","4-Deoxypyridoxine","Rhizocticin A","(-)-Betonicine","Ribostamycin","gamma-L-Glutamylputrescine","Retinol / Retinol skeleton","Mdp-gdp","3-Des(dimethylaminoethyl)-3-acetic acid zolmitriptan","8-[(1R,2R)-3-Oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate","Pyrenophorol","Threoninyl-Tryptophan","2,3-Dihydrowithanolide E","LysoPC(16:0/0:0)","12,15-epoxy-13,14-dimethyleicosa-12,14-dienoic acid","5α-Androst-16-en-3α-ol","Anofinic acid","1-Methyl-L-histidine","Levonordefrin","METENEPROST","N5-formyl-N5-hydroxy-L-ornithine","Isohumbertiol","SM(d16:2(4E,8Z)/20:4(5Z,8Z,11Z,14Z)-OH(20))","Imazodan","Lividomycin B","Melibiose","Tussilagine","9,12,15-Octadecatrien-1-ol","(7R,E)-8-((1S,Z)-1-hydroxy-1-methylhexahydro-2H-quinolizin-3(4H)-ylidene)-4,7-dimethyloct-4-en-3-one","Cholestane-3,7,12,25-tetrol-3-glucuronide","Fusarochromanone","Methyl 1-methylpyrrole-2-carboxylate","Maltotriose","3-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid","Pressinoic acid","Glycyl-histidyl-arginyl-proline","MG(18:1(9Z)/0:0/0:0)[rac]","Nicotinamide","N-Lactoylleucine","n6,n6-dimethyladenosine","5β-CHOLANIC ACID-3α, 12α-DIOL N-(2-SULPHOETHYL)-AMIDE","L-Menthyl (R,S)-3-hydroxybutyrate","6-Hydroxymelatonin","Oxytetracycline","Antheraxanthin","Tridemorph","Bis(glutathionyl)spermine disulfide","MILTEFOSINE","3''-Oxoribostamycin","Ascorbigen","O-propanoyl-carnitine","PE-NMe(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","2-Isopropylfuran","2,5-Dihydroxybenzamide","3-O-alpha-Mycarosylerythronolide B","DG(14:0/PGJ2/0:0)","Stearoyllactic acid","1-[(5-Amino-5-carboxypentyl)amino]-1-deoxyfructose","Mangalkanyl glucoside","Pentenylbenzene","His Gly Val Thr","Phthalic acid Mono-2-ethylhexyl Ester","5-Heptadecyl-1,3-benzenediol","Pranidipine","Palmyramide A","PC(16:0/0:0)[U] / PC(16:0/0:0)[rac]","PE(18:4(6Z,9Z,12Z,15Z)/P-16:0)","1-Hydroxypyrene glucuronide","7,8-Dehydro-3,4-dihydro-beta-ionol","1-Pentanol","1,1-Difluoroethane","7-Methylxanthosine","N-Acetyl-L-citrulline","1,2,5,6-Tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one","Heptanal","2,6-Dihydroxy-3-cyanopyridine","Nonate","Phloretic acid","2E,9-Decadienal","2-(5-Methyl-2-furanyl)-3-piperidinol","Histidinyl-Lysine","3-(2-HYDROXYPHENYL)PROPANOATE","nostopeptolide A1","Pseudaminic acid","7-Deoxyloganetic alcohol","N-Alpha-acetyllysine","Galactosylglycerol","Methionyl-Lysine","Disialosyl galactosyl globoside","2-Isopropyl-1,4-hexadiene","Thonzylamine","Ile Gly Pro","Spirolide E","Spirolide B","Spirolide D","4-Hydroxybenzylamine","Aminofurantoin","PIRACETAM","O-Arachidonoyl Glycidol","Terfenadine","Epipodophyllotoxin derivitive","4a-Hydroxytetrahydrobiopterin","Etonogestrel","5-Phospho-alpha-D-ribose 1-diphosphate","tomatidine","5,7-Megastigmadien-9-ol glucoside","2'-Deamino-2'-hydroxyneamine","Ondansetron","(7b,10a)-3-Hydroxy-1,3,5-cadinatrien-9-one","(3R,4R,5R)-3-Fluoro-5-(hydroxymethyl)oxolane-2,3,4-triol","Tabun","Nicotinamide-beta-riboside","Solanidine","Xestoaminol C","Humulinic acid A","6-Lactoyl-5,6,7,8-tetrahydropterin","Mesoridazine","Androstenediol dipropionate","Polidocanol","Terpentecin","Citrulline","2-Amino-4-ethoxy-3-hydroxybutanoic acid","(2S,3R)-2-Amino-4-octadecene-3-ol","2-methyl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypyran-4-one","Maduropeptin chromophore","Enol-phenylpyruvate","18-Carboxy-dinor-LTE4","N-VINYL-2-PYRROLIDONE","Cervonyl carnitine","2,6-Dihydroxynaphthalene","Neopterin","PA(8:0/5-iso PGF2VI)","V-Pyrro/NO","(3Z)-Phycocyanobilin","Marindinin","Trihexosylceramide (d18_1_18_0)","Dihydroneopterin phosphate","Demethoxycurcumin","Cyanosulfurous acid anion","Arginylglutamine","Glutathione","12,13-DHOME","Phenylalanylserine","Plicamycin","5,8,11-Eicosatriynoic Acid","Ethylcyclohexane","1-Monopalmitin","2-Methyl-5-propyloxazole","5,6,7,8-tetrahydro-2-Naphthoic Acid","Oleamide","Naphthalene dihydrodiol","PG(a-15:0/LTE4)","1b,3a,7a-Trihydroxy-5b-cholanoic acid","5alpha-Cholestanol","N5-(4-Methoxybenzyl)glutamine","7-Methylguanosine 5'-phosphate","Estradiol-17beta 3-glucuronide","Chromane","Prunin 4'',6''-di-O-gallate","Taxine B","2,6-nonadienoic acid","L-Ornithine","Myrcene","Piperideine","13-Docosenamide","PC(18:3(6Z,9Z,12Z)/24:1(15Z))","Asparaginylisoleucine","PG(18:1(12Z)-O(9S,10R)/i-12:0)","tetrahydropyridoindole","Phthalic acid","(R)-Carvotanacetone","6-Methylcoumarin","Benzyl alcohol","Glutathionylaminopropylcadaverine","(±)-Aegeline","PI(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/PGE2)","1-(9Z-Nonadecenoyl)-glycero-3-phosphoethanolamine","Methylpicraquassioside A","1-Octadecanoyl-sn-glycero-3-phosphoethanolamine","1-Deoxy-11-oxopentalenate","Tovophyllin A","Evocarpine","1,8-Menthadien-2-ol","1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycero-3-phosphate","bk-MDDMA","5-Ribosylparomamine","(S)-2,3-Dihydro-3,5-dihydroxy-2-oxo-3-indoleacetic acid 5-[glucosyl-(1->4)-b-D-glucoside]","Dibutylamine","7-Aminobenzo[d]isothiazol-3(2H)-one 1,1-dioxide","Sphingosine 1-phosphate (d19:1-P)","Glutaminylarginine","TRIOXIFENE","Pro Pro Arg Thr","Aminoimidazole ribotide","Dhurrin 6'-glucoside","N(alpha)-Benzyloxycarbonyl-L-leucine","Atropaldehyde","genipin","Cyclo(-D-Tyr-Arg-Gly-Asp-Cys(carboxymethyl)-OH) sulfoxide","Prolylglycine","Methyl (3b,11x)-3-Hydroxy-8-oxo-6-eremophilen-12-oate","1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycero-3-phosphoethanolamine","Gaboxadol","Punctaporonin B","5-Phenylvaleric acid","Triamcinolone","PS(O-16:0/13:0)","Sebacoyl-L-carnitine","Stearidonic acid","Benzenebutanoic acid, alpha-(acetylamino)-2-amino-gamma-oxo-","Phenformin","Glycidyl oleate","Auramine","cis-1,2-Dihydroxy-1,2-dihydro-7-methylnaphthalene","Pyrethrosin","9-HOTE","(1-Ribosylimidazole)-4-acetate","L-cis-3-Amino-2-pyrrolidinecarboxylic acid","MG(19:0/0:0/0:0)","LysoPI(18:2(9Z,12Z)/0:0)","beta-D-glucosaminyl-(1->4)-beta-D-glucosamine","2-Amino-2,3,6,7-tetrahydro-1H-pteridin-4-one","Tetrahydropersin","10-Deoxymethymycin","Heptaminol","Licorice glycoside D1","Umbelliferone","Sagittariol","Guanine","CMP-N-trimethyl-2-aminoethylphosphonate","3,4-Epoxy-6Z,9Z-eicosadiene","Rifampicin","4-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate","N-Acetylserine","Phenmetrazine","3-methylheptanedioylcarnitine","CDP-DG(a-21:0/PGF1alpha)","1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol","C17 Sphinganine","CL(10:0/11:0/11:0/13:0)","5-Phenyl-1,3-pentadiyne","dGMP","Thr Arg His Thr","L-Arogenate","Rimantadine","Octadecanol","6'''-Deamino-6'''-hydroxyparomomycin II","LysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z))","Lepidiumterpenyl ester","Volicitin","Cellotetraose","Tokinolide B","CDP-DG(i-19:0/i-24:0)","DG(16:1(9Z)/18:1(9Z)/0:0)[iso2]","Glycerol phenylbutyrate","3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al","gamma-Humulene","Glutamyl pyruvate","Stachyose","Glutethimide","9-Oxononanoic acid","URSINIC ACID","Antibiotic X 14889A","beta-Alanyl-L-arginine","Phenylalanylarginine","Pralnacasan","Rosifoliol","N1,N5,N10-Tris-trans-p-coumaroylspermine","3-(4-Methylphenyl)oxiranecarboxylic acid","Cinnamyl butyrate","L-Glutamate","N2-Ethyl-2'-deoxyguanosine","Cys Ser Ser Cys","Ecgonine methyl ester","Dihydrocorynantheine","Entecavir","Resiquimod","Menthol","1-Oleoyl-rac-glycerol","Colforsin daropate","trioxyethylene dimethacrylate","(E)-3-(4-Tert-butylphenylsulfonyl)acrylonitrile","L-3-Aminodihydro-2(3H)-furanone","4-Aminobutanoate","9,10-DiHOME","4-Oxofenretinide","22-Hydroxydocosanoic acid","Ethyl 3-hydroxydodecanoate","PL","(+/-)-Methyl 5-acetoxyhexanoate","Zymosterol","Epothilone D","Zalcitabine","Leukotriene F4","Creatine riboside","Geldanamycin","2-[5-[2-[2-[5-(2-hydroxybutyl)oxolan-2-yl]propanoyloxy]butyl]oxolan-2-yl]propanoic acid","lys-met","(E)-4,8-Dimethyl-1,3,7-nonatriene","Cyclomarin A","3-Methyl-1-(2,4,6-trihydroxyphenyl)-1-butanone","D-Glucosaminide","3-Hydroxymethyltriazolopthalazinone glucuronide","(1R,4R,4'R,5S,5'S,6R,6'S,7R,9R,11R,12R,13S,14S)-12-[(3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-4-ethyl-5,5',6,11-tetrahydroxy-4'-methoxy-4',5,6',7,9,11,13-heptamethylspiro[3,15,17-trioxabicyclo[12.4.0]octadecane-16,2'-oxane]-2,8-dione","Vinblastine","(10S)-Juvenile hormone III diol","2,3-Methylenedioxymethcathinone","Aminomethyl fluorescein","PC(14:0/0:0)","Leu-Leu-Leu","Dopamine glucuronide","1,5-Bis(4'-glucopyranosyloxy-3'-hydroxyphenyl)pent-4-en-1-yne","(±)-Octanoylcarnitine","Psma-hbed-CC","PC(2:0/20:4(5Z,8Z,11Z,14Z)-OH(20))","Perilloside B","PC(P-18:0/PGE1)","Lippioside I","Lucidenolactone","dTMP","Validoxylamine A","13-Dihydrodaunorubicin","2-Propylsuccinic acid","N-Oleoyl Histidine","Phorbol","7-Methylhypoxanthine","Azacridone A","LysoPE(0:0/22:2(13Z,16Z))","3-Hydroxylidocaine","dCMP","Cholesterol","Neomycin B","PC(P-16:0/18:1(12Z)-2OH(9,10))","Tenuazonic acid","val-lys","4-(2,6,6-Trimethyl-1-cyclohexenyl)-2-butanol","PG(PGJ2/i-19:0)","L-cis-4-(Hydroxymethyl)-2-pyrrolidinecarboxylic acid","6-Ethyl-4-methyl-3E,5E,7E-decatriene","Tunicamycin A","Alosetron","MG(0:0/22:2(13Z,16Z)/0:0)","2-Isopropylmaleate","Tunicamycin I","4-Amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline","Sphingosine 1-phosphate","Lactodifucotetraose","4-Methyl-1-phenyl-2-pentanone","N-[(3a,5b,7b)-7-hydroxy-24-oxo-3-(sulfooxy)cholan-24-yl]-Glycine","Cytosine","b-D-Glucopyranosiduronic acid, (3a,5b)-24-[(carboxymethyl)amino]-24-oxocholan-3-yl","3-Amino-1-(3-(cyclohexylmethoxy)phenyl)propan-1-ol","Oleylcarnitine","Calcitetrol","7-benzyl-11,14-dimethyl-16-(2-methylpropyl)-10,13-di(propan-2-yl)-17-oxa-1,5,8,11,14-pentazabicyclo[17.3.0]docosane-2,6,9,12,15,18-hexone","Deoxyguanidinoproclavaminic acid","Furanogermenone","4-Amino-anhydrotetracycline","C18-OH Sulfatide","6'-Dehydro-6'-oxoparomamine","Pro Asn Pro Glu","Alliofuroside A","7,8-Dihydro-7,8-dihydroxykynurenate","Irene","Carboxymethyl chitosan","5-Ethyl-3-methyl-2E,4E,6E-nonatriene","Homocarnosine","NCGC00380639-01_C38H62O10_","NCGC00169248-02_C22H34O5_7-Oxabicyclo[4.1.0]hept-3-ene-2,5-diol, 4-(hydroxymethyl)-1-[[1,4,4a,5,6,7,8,8a-octahydro-5-(hydroxymethyl)-2,5,8a-trimethyl-1-naphthalenyl]methyl]-","(4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,1 6,19-Docosahexaenoic acid","3'-Methyl-2',4',6'-trihydroxydihydrochalcone","Oxidized Latia luciferin","3beta,7alpha-Dihydroxy-5-cholestenoate","CDP-DG(18:0/22:3(10Z,13Z,16Z))","Docosahexaenoyl PAF C-16","MG(0:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)","Tryptophyl-Phenylalanine","Geranyl hexanoate","Anthranilate","Histamine-betaxanthin","Arabinosylhypoxanthine","N-Fructosyl isoleucylglutamate","Gentamicin C2","4-Hydroxyindole","Aminoacetone","Terpendole G","10-Oxooctadecanoic acid","Finrozole","(±)-Ibuprofen","Ethylbenzene","PE-NMe(13D5/13M5)","Citrunobin","9-O-Acetylneuraminic acid","Vitamin D3 / Cholecalciferol (Vitamin D3) skeleton","PE(18:1(9Z)/0:0)","delta-Elemene","7,8 Dihydrokawain","1,2-Cyclohexanedicarboxylic acid","D-Glycero-D-galacto-heptitol","Benzenebutanoic acid","6E,8E,12E,14E-Hexadecatetraen-10-ynoic acid","PI(20:5(5Z,8Z,11Z,14Z,17Z)/0:0)","3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al","2-Hydroxycyclopent-2-en-1-one","BENZYDAMINE","Farfugin A","N,N-dimethyl-Safingol","1-fluorocyclohexadiene-cis,cis-1,2-diol","Pergolide","Tetrahydropentoxyline","Physalin O","Erythro-9-hydroxy-nonyl-adenine","Proclavaminic acid","Ergothioneine","Palmitoyl Ethanolamide","Buspirone N-oxide","LysoPE(0:0/22:0)","2-Methyl-2H-1,3-benzoxazin-4(3H)-one","1-(11Z,14Z-eicosadienoyl)-glycero-3-phosphate","Ethionamide","(24E)-3alpha,15alpha-Diacetoxy-23-oxo-7,9(11),24-lanostatrien-26-oic acid","PHENACYLAMINE","MG(0:0/18:2(9Z,12Z)/0:0)","Ginsenoyne J","Calamendiol","Hymenoxon","PE(20:5(5Z,8Z,11Z,14Z,17Z)/0:0)","8-Methylthiooctyl-desulfoglucosinolate","Deacetylcephalosporin C","O-Acetylcarnitine","3'-C-Ethynylcytidine","1,2-dihydrostilbene","Bardoxolone methyl","Val Phe","3,7-Dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide","LysoPI(18:1(9Z)/0:0)","epsilon-Deoxy-fructosyl-lysine","11-trans-LTC4","trans-4-Aminocyclohexanecarboxylic acid","Indoline","dTDP-4-amino-2,4-dideoxy-beta-L-xylose","β-PHENYL-gamma-Aminobutyric Acid","PC(18:0/18:4(9E,11E,13E,15E))","PHENYLACETOHYDROXAMIC ACID","Phe Gly Ile Pro","2,6-dimethyl-2-octene","N-(3-oxo-hexanoyl)-homoserine lactone","Delta4-Dafachronic acid","Incadronic acid","LysoPC(22:5(4Z,7Z,10Z,13Z,16Z))","3,9,15-Tribenzyl-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone","Ilaprazole","Gladiatoside B3","Sedoheptulose","N-(4-Methoxyphenyl)-all-trans-retinamide","Ascladiol","2-Aminoheptanoate","NCGC00381156-01_C24H30O6_Methyl 3-[(1E,3E)-3,5-dimethyl-1,3-heptadien-1-yl]-8-hydroxy-6a,8-dimethyl-6-oxo-6a,8,9,9a-tetrahydro-6H-furo[2,3-h]isochromene-9-carboxylate","4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine","10-Deacetylbaccatin III","Piperidine","Arginyl-Glutamine","Colnelenic acid","2-Feruloyl-1-sinapoylgentiobiose","8-Isoquinoline methanamine (hydrochloride)","Phosphocholine","Paromamine","Fluoroacetate","Phenethylamine glucuronide","2,3,6,7-Tetrahydro-7-methylcyclopent[b]azepin-8(1H)-one","MG(0:0/18:3(9Z,12Z,15Z)/0:0)","(2S,3R,E)-2-Amino-4-tetradecene-1,3-diol","Isoeugenyl acetate","LPE 18_2","Chenodeoxycholylphenylalanine","1,2,4-Benzotriazin-3-amine 1-oxide","NCGC00385388-01_C21H34O11_(1R,4S,7S,8S,9R,12E,20R,21R,22S,23S)-7,8,21,22,23-Pentahydroxy-12,16-dimethyl-3,5,10,19,24-pentaoxatricyclo[18.3.1.0~4,9~]tetracos-12-en-11-one","(2S,3R,5R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(2R,3R,5R)-2,3,6-trihydroxy-5,6-dimethylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one","Isopropyl beta-D-glucoside","L-Pipecolate","2,6-Diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo(3,2-d)pyrimidin-4-one","Juvenile hormone III","Glu Pro Pro","Isofucosterol 3-O-[6-O-(9,12-Octadecadienoyl)-b-D-glucopyranoside]","Pyridoxine-5'-phosphate","valinomycin","Tranylcypromine glucuronide","PGF2α Alcohol methyl ether","O-Succinyl-L-homoserine","Tyrosylhydroxyproline","Prolyl","microcystin RR","1-Naphthylmethanol","arachidonoylethanolamine","alpha-Corocalene","2-Methylbutyroylcarnitine","Tridecanol","Mithramycin","Bialaphos","Nonacosanoic acid","3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione","Octanoylglucuronide","PGF2a ethanolamide","5-Hydroxyindoleacetic acid","Pteroyltriglutamic acid","PG(i-12:0/18:1(12Z)-O(9S,10R))","alpha-Amylcinnamaldehyde","Gingerglycolipid B","alpha-Methylstyrene","Acetylenic acids; 17-Octadecen-9-ynoic acid","Methyl helicterate","Hydralazine pyruvate hydrazone","L-Olivosyl-oleandolide","6-Methoxymusizin 8-O-[b-D-glucopyranosyl-(1->6)-b-D-glucopyranosyl-(1->3)-b-D-glucopyranosyl-(1->6)-b-D-glucopyranoside]","7,8-Dihydro-2'-deoxyguanosine","Misoprostol (free acid)","Quinoline-4,8-diol","hydrocinnamic acid","cis-4-Carboxymethylenebut-2-en-4-olide","3alpha-Hydroxy-3,5-dihydromonacolin L acid","1-Piperidinecarboxaldehyde","Allomaltol","8,8a-Diepiswainsonine","LysoPC(18:0/0:0)","L-Formylkynurenine","2-Ethylhydracrylic acid","LysoPE(16:1(9Z)/0:0)","Penbutolol","Benzoic anhydride","PC(DiMe(13,5)/PGJ2)","Vitamin D3","Icosenoic acid","(E)-5,8-Megastigmadien-4-one","(R)-1-O-[b-D-Glucopyranosyl-(1->6)-b-D-glucopyranoside]-1,3-octanediol","S-(2-Carboxyethyl)-L-cysteine","Dihydro-3-coumaric acid","Tetradecanoylcarnitine","NCGC00381119-01_C13H22O6_2-Furanacetic acid, tetrahydro-alpha-methyl-5-(2-oxopropyl)-, 2,3-dihydroxypropyl ester","Cotinine glucuronide","OR-1896","N,N-Dimethylsphingosine","FMLP","m-Xylene","Alacepril","CDP-DG(PGJ2/a-15:0)","(R)-11,12,13-Trinor-1(5),6,9-guaiatrien-8-one","3-Methyl-2,5-furandione","N-Glycoloyl-neuraminate","5-Hydroxy-3,4-dihydrocarbostyryl","Calcipotriol","L-Homocysteic acid","Abt-510","DG(14:0/20:1(11Z)/0:0)","(E,E)-2,4-Hexadienal","Hydroxyhomodestruxin B","Decanoic acid","Dehydrosafynol","1-Octen-3-yl glucoside","Valyl-Proline","1-[5-(2-Cyclopropyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)thiophen-2-yl]cyclopent-3-ene carboxylic acid","Flumethasone Pivalate","25-Hydroxy-6,19-dihydro-6,19-ethanovitamin D3","Agavoside A","2-(10-heptadecenyl)-6-hydroxybenzoic acid","Medicagenic acid 28-O-[b-D-xylosyl-(1->4)-a-L-rhamnosyl-(1->2)-a-L-arabinosyl] ester","L-Ascorbic acid","4-Acetyl-2-methylpyridine","Corchorusoside A","Indanone","6'''-Deamino-6'''-oxoparomomycin II","Adafosbuvir","Ala Tyr Lys","4-Hydroxycoumarin","Arachidonate","LysoPC(16:1(9Z))","(Z)-3-Nonen-1-ol","Cinnamyl formate","1H-Pyrido[3,2-c][1,2]diazepine","Glyceraldehyde phosphate","Histidinyl-Tryptophan","2,4-Undecadienal","Delapril","2-Methyl-1,3-cyclohexadiene","CDP-DG(6 keto-PGF1alpha/i-12:0)","1,2,3,4,5,6-Hexahydro-7H-cyclopenta[b]pyridin-7-one","Glyzarin","4-hydroxybenzoate","Spermidine","2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one","4-hydroxy-5-[2-[(E)-3-hydroxyprop-1-enyl]-4-methylphenyl]-3-methylhexan-2-one","(1R,6R)-1,4,5,5a,6,9-Hexahydrophenazine-1,6-dicarboxylate","Adenosine, 8-(butylamino)-N-cyclopentyl-","4(1H)-Pyridinone, 2-ethyl-3-hydroxy-1-(2-hydroxyethyl)-","Cholylasparagine","PRIMA-1","(2R,4S)-2-Aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione","p-Mentha-1,3,8-triene","NCGC00381144-01_C15H24O2_(4S,4aR)-4-(Hydroxymethyl)-3,4a,8,8-tetramethyl-4a,5,6,7,8,8a-hexahydro-1(4H)-naphthalenone","Metanephrine","lpc(22-4_0-0)","Pro Pro Pro","(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-17-((2R)-6,7-dihydroxy-6-methylheptan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol","PC(O-22_0_22_6(4Z,7Z,10Z,13Z,16Z,19Z))","Zearalenone","4E,8-Nonadienal","N-(4-Aminobutyl)-N-ethylisoluminol","epsilon-(Hexanoyl)lysine","5-hydroxy,3E-sphingosine","3-Methylcyclopentene","CAY10444","DG(13:0/PGE2/0:0)","2-Hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate","1-Ethylaziridine","Cyclo(D-Trp-D-Asp-Pro-D-Ile-Leu)","13-Tetradecene-1,3-diyne-6,7-diol","Creatinine","4-Vinylcyclohexene","Abrine","N-Acetylneuraminic Acid","Rifabutin","Lichenin","DG(14_0_16_0_0_0)","PE(24:0/22:6(4Z,7Z,10Z,13E,15E,19Z)-OH(17))","Glycolithocholic acid","7',8'-Dihydro-8'-hydroxycitraniaxanthin","Zidovudine","Mirogabalin","PC(DiMe(11,5)/22:6(5Z,8E,10Z,13Z,15E,19Z)-2OH(7S, 17S))","Icofungipen","Palmitic amide","BUFEXAMAC","LysoPE(20:2(11Z,14Z)/0:0)","1-Ipomeanol","1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamide","5-Methyldeoxycytidine","2-Oxo-10-methylthiodecanoic acid","Pro Gln Leu Asp","5-Fluorouridine","Pacific Ciguatoxin 4A","Bulleyaconitine A","Atractylodin","2,3-octadienoylglycine","4-O-Methyl-a-D-glucosyl-(1->2)-b-D-xylosyl-(1->4)-D-xylose","24,25-Diacetylvulgaroside","4E,6E,10Z-Hexadecatrien-1-ol","Dalbergin","2-(2-Furanyl)-3-piperidinol","Dehydrovomifoliol","N-Acetyl-2,6-diethylaniline","3β-Hydroxy-19-oxochol-5-en-24-oic Acid","LysoPE(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)","Crotanecine","PG(i-12:0/PGE1)","2-Heptadecylfuran","Atorvastatin","Tryptophol","Revefenacin","13-Demethylspirolide C","Ethenodeoxyadenosine","Hydroxyprolyl-Valine","(9Z,12Z,15Z)-Octadecatrienoic acid","NCGC00380976-01_C28H42N2O7_(4E,10E)-13,20-Dihydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(22),4,10,18,20-pentaen-9-yl carbamate","Mertansine","Propylene glycol alginate","Dexelvucitabine","Honyudisin","LysoPE(P-18:0/0:0)","Sphinganine","Bax inhibitor peptide V5","Methyl Phenylglyoxalate","2-Hexylidenecyclopentanone","Metoprolol","Vinylacetylene","12-Methyl-13-tridecanolide","Amylopectin","Furo(3,4-b)pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxo-, ethyl ester","(R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pent-2-enoic acid","Oleoyl Ethyl Amide","Farnesyl acetone","Tridecanal","1-(1-Methylethenyl)-4-(1-methylethyl)benzene","Furost-5-ene-3beta,22,26-triol","PE(24:0/20:5(6E,8Z,11Z,14Z,17Z)-OH(5))","LysoPE(0:0/18:0)","(3xi,5Z)-1,5-Octadien-3-ol","Embelin","5'-Hydroxy-3'-methoxysativan","Lysine conjugated cholic acid","4-Amino-1-[(1S,2S,4S)-4,5-bis(hydroxymethyl)-2-bicyclo[3.1.0]hexanyl]pyrimidin-2-one","2-Oxo-2,3-dihydrofuran-5-acetate","Glutathionylspermidine","(R)-2-(4-(Tert-butoxycarbonyl)morpholin-3-yl)acetic acid","Coagulin R 3-glucoside","alpha-Terpineol propanoate","Liquiritigenin 4'-[3-acetylapiosyl-(1->2)-glucoside]","PI(PGJ2/16:0)","Nystatin","gly-gly-phe","20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid","NCGC00385331-01_C31H44O12_(2E)-3,7-Dimethyl-2,6-octadien-1-yl 3-O-(6-deoxy-alpha-L-mannopyranosyl)-4-O-[(2E)-3-(4-hydroxyphenyl)-2-propenoyl]-beta-D-glucopyranoside","Adrenochrome o-semiquinone","dTDP-acarviose-7-phosphate","2,6-Dimethylquinoline","PC(O-15:0/O-1:0)[U]","Desferrioxamine D1","5-Formiminotetrahydrofolate","Dopaquinone","Oleoylcholine","PE(20:5(5Z,8Z,11Z,14Z,17Z)/24:1(15Z))","L-Histidinol","1,2-Disinapoylgentiobiose","NCGC00381448-01_C15H24O5_1-Naphthalenecarboxylic acid, 1,4,4a,5,6,7,8,8a-octahydro-1,4-dihydroxy-2-(hydroxymethyl)-5,5,8a-trimethyl-","6-Ethylchenodeoxycholic acid","Sulfapyridine","Feruloylputrescine","Asparaginyl-Gamma-glutamate","Pedunculoside","Frovatriptan","N-Benzoyl-L-tyrosine ethyl ester","Panaxydiol","Monoisobutyl phthalic acid","(15a,20R)-Dihydroxypregn-4-en-3-one 20-[glucosyl-(1->4)-6-acetyl-glucoside]","13,17-Octadecadiene-9,11-diynoic acid, (Z)-","1H-Indole-4-acetic acid, 2,3-dihydro-2-oxo-","1,8-Diazacyclotetradecane-2,9-dione","Deoxyuridine","Asp Leu Trp Trp","PA(17:1(9Z)/0:0)","allo-Protolichesterinic acid","6-Hydroxydec-6-enedioylcarnitine","Tapentadol","Tocopheronic acid","PE(15:0/20:2(11Z,14Z))","5-Hydroxymethyl-2-furancarboxaldehyde","N-Acetylmannosamine","Valylisoleucine","N1-(alpha-D-ribosyl)-5,6-dimethyl-benzimidazole","1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholine","D-4'-Phosphopantothenate","Carmofur","Ganglioside GM3 (d18:0/14:0)","Cortol","t-4-AMINOCROTONIC ACID (TACA)","beta-Funaltrexamine","Indoleacrylic acid","Novapikromycin","N-Isopropyl-p-toluamide","Pro Asp Asp Lys","N-acetyl zonisamide","isoxazolyl penicillin","2,6-nonadienal","CMP-pseudaminic acid","17alpha,20alpha-Dihydroxypregn-4-en-3-one","(3E,5E)-1,3,5-octatriene","2-(2-Thienylmethylene)-1,6-dioxaspiro[4.4]non-3-ene","(3beta,22R,23R,24S)-3,22,23-Trihydroxystigmastan-6-one","2-(5,8-Tetradecadienyl)cyclobutanone","Mozenavir","Linamarin","RIOPROSTIL","Tetrahydrofurfuryl butyrate","lys-tyr","L-Arginine","ETHYL 1-BENZYL-3-HYDROXY- 2-OXO[5H]PYRROLE-4-CARBOXYLATE","(S)-3-(Azetidin-2-ylmethoxy)pyridine","2-Arachidonoylglycerol","Islatravir","D-Pipecolic acid","2,3-Dihydro-5-(5-methyl-2-furanyl)-1H-pyrrolizine","Docosahexaenoyl Ethanolamide","Gibberellin A20","PG(i-12:0/PGJ2)","1-Nitroheptane","Cyclo((2R)-2-aminobutanoyl-N2-methyl-L-arginylglycyl-L-alpha-aspartyl-3-(aminomethyl)benzoyl)","3-Methyl-2-(1-pyrrolidinyl)-2-cyclopenten-1-one","GRK2 Inhibitor","4(5)-EpDPE methyl ester","13,14-Dihydro PGE1","N-Glycolyl-D-glucosamine","LysoPE(0:0/20:4(5Z,8Z,11Z,14Z))","Prostaglandin F2a-d9","4,6-Decadiyn-1-ol","Capsi-amide","(4-{4-[2-(gamma-L-Glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine","5-carboxycytidine","Cholesterol glutamate","Gentamicin A sulfate","3E,7-Dimethyl-1,3,6-octatriene","Trihexosylceramide (d18_1_16_0)","3,5-Dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one","3,5,7-Trimethyl-2E,4E,6E,8E-undecatetraene","Retinoyl-AZT","(±)-(Z)-2-(5-Tetradecenyl)cyclobutanone","Hovenidulcigenin A","Caffeine","Ectocarpen","Glyceryl monolinoleate","Soyasaponin I","Hydroxypropionylcarnitine","gamma-Glutamylcysteine","Vanylglycol","Sarpogrelate","4-Methylbiphenyl","N-Hydroxynorcocaine","1-Hydroxy-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-2-phosphocholine","Antipyrine","DG(19:0/PGE2/0:0)","PE-NMe(16:1(9Z)/22:5(4Z,7Z,10Z,13Z,16Z))","2-Amino-1,3-eicosanediol","3-Hydroxy-9-hexadecenoylcarnitine","Plazomicin","(+)-Vulgraon B","Ozagrel","Aklaviketone","Malptll","Peanut oil, hydrogenated","PI(22:4(7Z,10Z,13Z,16Z)/6 keto-PGF1alpha)","PE(20:0/PGE1)","Dibutyl sulfide","2-methylidene-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybutanoic acid","PS(19:1(9Z)/22:4(7Z,10Z,13Z,16Z))","Coenzyme B","Cyclocreatine","Filfiline","L-2-Amino-3-methylenehexanoic acid","Betaine aldehyde","Glycine xylidide","morpholino","Chavicol","4-Fluorocyclohexane-1-carboxylic acid","DL-Kavain","Alanylisoleucine","3-Isochromanone","6-Fluoropyridoxal","4-Amino-3-hydroxybutanoylcarnitine","1-Methylnaphthalene","Pyridoxamine phosphate","2',4',6',3,4-Pentahydroxy-3'-geranyl-5-prenyldihydrochalcone","4'-Methoxybenzophenone-2-carboxylic acid","lpc(20-0_0-0)","Tanshinone IIA","5,7-Dihydroxy-3,6,8,4'-tetramethoxyflavone 7-glucosyl-(1->3)-galactoside","ile-lys","3'-Prenylapigenin 7-[rhamnosyl-(1->6)-glucoside]","trans-isoeugenol-O-glucuronide","LysoPC(6:0/0:0)","Thymidine","N-Methylmyosmine","2-Methylerythritol","PE(P-16:0/18:1(12Z)-2OH(9,10))","Oleandomycin","3-methyl-1-heptene","Phytocassane D","8-(Methylthio)octanenitrile","LysoPE(18:2(9Z,12Z)/0:0)","MG(0:0/18:0/0:0)","Glu Phe","Nitrosylsulfuric acid","2-Piperidinone","Fevicordin B 2-[rhamnosyl-(1->4)-glucosyl-(1->6)-glucoside]","1400W","dIDP","5,7,8-Trihydroxyflavanone 7-glucoside","Benzaldehyde","m-Coumaric acid","Tecastemizole","Acremoauxin A","Mellein","Tetracycline","4-Oxo-1-(3-pyridyl)-1-butanone","Gly His","Avermectin B1a","2-(Arabinosylamino)-3-(glucosylamino)propanenitrile","Cholylphenylalanine","(16R,17R)-3-Cyclopentyloxy-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-16,17-diol","5,7-Diethyl-9-methyl-3E,5E,7E,9E-tridecatetraene","5'-Deoxyadenosine","(R)-Pterosin B","2-Oxo-5-(3,3-dimethylguanidine-1-yl)pentanoic acid","Asp Asp Asp","N-palmitoyl serine","N-Acetylbialaphos","Raffinose","PC(P-18:1(11Z)/PGE2)","3-Methylcytidine","NCGC00386029-01_C14H20O8_2-Hydroxy-4-(2-hydroxyethyl)phenyl beta-D-glucopyranoside","3-Amino-2,3-dideoxy-scyllo-inosose","MG(18:0/0:0/0:0)","Milbemycin beta2","Toluene","Zotarolimus","lasalocid","Deoxycytidine","Valylproline","gamma-Glutamylglycine","1-Benzazepine","Biopterin","Leonoside A","PC 34_0"],"additional_accession":[]},"is_claimable":false,"name":"XMulti-omics reveals zearalenone-induced hepato-intestinal injury and growth dysregulation in largemouth bass (Micropterus salmoides)","description":"Zearalenone (ZEN), a prevalent Fusarium-derived mycotoxin in plant protein-based aquafeeds, poses severe threats to farmed aquatic animals. However, its toxic effects and underlying mechanisms on the commercially critical largemouth bass (Micropterus salmoides) remain largely uncharacterized. Here, juvenile M. salmoides were fed diets containing 0, 100, and 1000 μg/kg ZEN for 28 days. Growth performance, hepato-intestinal histopathology, barrier function, and antioxidant/biochemical parameters were systematically determined, combined with 16S rRNA sequencing and untargeted metabolomics to elucidate ZEN’s toxic mechanism. Dietary ZEN induced biphasic growth dysregulation: low-dose ZEN significantly promoted fish growth, while high-dose ZEN impaired feed efficiency, caused severe oxidative damage, histopathological lesions, and tight junction gene downregulation in the liver and intestine. ZEN exposure drastically disrupted intestinal microbial homeostasis, reduced core commensal bacteria, enriched potential pathogens, and disturbed host metabolic pathways related to nutrient transport, amino acid/lipid metabolism, and inflammatory response. This study revealed that ZEN induced growth dysregulation and hepato-intestinal injury in M. salmoides via disrupting gut microbial and metabolic homeostasis, providing novel insights into ZEN toxicology in carnivorous fish and theoretical support for mycotoxin control in aquaculture.","dates":{"publication":"2026-05-05","submission":"2026-05-05"},"accession":"MTBLS14430","cross_references":{"HMDB":["HMDB0000251","HMDB0000725","HMDB0060244","HMDB0013253","HMDB0037848","HMDB0301920","HMDB0000982","HMDB0038581","HMDB0002299","HMDB0246561","HMDB0014685","HMDB0033750","HMDB0248553","HMDB0031950","HMDB0000101","HMDB0003331","HMDB0014831","HMDB0246848","HMDB0001445","HMDB0000056","HMDB0002005","HMDB0000122","HMDB0000565","HMDB0249913","HMDB0253945","HMDB0000656","HMDB0258340","HMDB0040544","HMDB0030872","HMDB0060822","HMDB0002266","HMDB0000225","HMDB0041561","HMDB0062696","HMDB0031712","HMDB0001062","HMDB0000833","HMDB0246552","HMDB0034473","HMDB0001296","HMDB0031859","HMDB0000337","HMDB0000211","HMDB0002271","HMDB0253580","HMDB0252537","HMDB0012254","HMDB0031339","HMDB0000942","HMDB0251715","HMDB0245529","HMDB0251529","HMDB0003072","HMDB0060826","HMDB0001321","HMDB0029965","HMDB0251528","HMDB0030276","HMDB0254198","HMDB0029427","HMDB0304542","HMDB0004195","HMDB0245680","HMDB0000098","HMDB0240587","HMDB0249683","HMDB0000250","HMDB0000095","HMDB0257351","HMDB0254845","HMDB0254505","HMDB0001264","HMDB0041862","HMDB0257208","HMDB0258407","HMDB0245282","HMDB0062273","HMDB0000150","HMDB0304273","HMDB0000175","HMDB0060467","HMDB0000916","HMDB0000721","HMDB0029415","HMDB0015188","HMDB0000592","HMDB0000785","HMDB0040804","HMDB0000176","HMDB0011111","HMDB0041031","HMDB0249812","HMDB0062181","HMDB0037844","HMDB0015017","HMDB0060551","HMDB0304718","HMDB0000300","HMDB0000168","HMDB0001241","HMDB0031727","HMDB0000044","HMDB0029037","HMDB0303672","HMDB0038228","HMDB0259121","HMDB0001564","HMDB0003337","HMDB0001137","HMDB0244983","HMDB0244734","HMDB0062762","HMDB0028739","HMDB0000939","HMDB0038859","HMDB0040341","HMDB0256840","HMDB0304002","HMDB0252607","HMDB0059743","HMDB0000292","HMDB0245452","HMDB0000157","HMDB0002035","HMDB0242170","HMDB0001138","HMDB0000094","HMDB0001430","HMDB0000296","HMDB0259050","HMDB0257980","HMDB0304350","HMDB0037841","HMDB0001929","HMDB0304409","HMDB0041970","HMDB0003407","HMDB0000190","HMDB0000034","HMDB0011756","HMDB0001538","HMDB0241650","HMDB0252529","HMDB0039124","HMDB0001645","HMDB0252807","HMDB0040038","HMDB0246316","HMDB0015197","HMDB0039780","HMDB0260224","HMDB0001439","HMDB0258638","HMDB0000824","HMDB0242130","HMDB0000625","HMDB0254271","HMDB0003254","HMDB0000960","HMDB0003423","HMDB0030097","HMDB0000130","HMDB0060415","HMDB0257989","HMDB0029756","HMDB0001245","HMDB0062177","HMDB0037845","HMDB0000167","HMDB0032807","HMDB0000158","HMDB0012710","HMDB0032991","HMDB0000254","HMDB0000240","HMDB0012492","HMDB0060397","HMDB0302288","HMDB0247591","HMDB0060413","HMDB0028866","HMDB0000195","HMDB0000133","HMDB0062708","HMDB0304219","HMDB0255300","HMDB0036861","HMDB0252539","HMDB0255536","HMDB0001030","HMDB0060401","HMDB0034569","HMDB0253951","HMDB0032833","HMDB0034812","HMDB0304386","HMDB0034214","HMDB0247540","HMDB0004483","HMDB0247218","HMDB0033987","HMDB0036379","HMDB0028713","HMDB0001501","HMDB0033689","HMDB0037840","HMDB0000988","HMDB0038321","HMDB0257834","HMDB0059611","HMDB0253927","HMDB0249460","HMDB0041086","HMDB0015149","HMDB0060450","HMDB0014808","HMDB0006240","HMDB0250452","HMDB0254315","HMDB0015214","HMDB0029035","HMDB0011171","HMDB0246877","HMDB0030409","HMDB0000930","HMDB0011690","HMDB0248799","HMDB0000549","HMDB0000299","HMDB0015339","HMDB0002128","HMDB0028983","HMDB0304292","HMDB0000884","HMDB0034252","HMDB0041313","HMDB0032385","HMDB0005796","HMDB0060829","HMDB0246938","HMDB0249229","HMDB0034367","HMDB0252269","HMDB0246595","HMDB0000684","HMDB0243625","HMDB0001173","HMDB0247093","HMDB0240720","HMDB0011658","HMDB0002062","HMDB0029530","HMDB0039068","HMDB0303030","HMDB0029684","HMDB0038750","HMDB0240291","HMDB0013751","HMDB0001049","HMDB0032947","HMDB0250791","HMDB0003831","HMDB0033453","HMDB0001253","HMDB0250668","HMDB0000235","HMDB0034934","HMDB0240296","HMDB0001259","HMDB0000991","HMDB0062175","HMDB0251886","HMDB0039656","HMDB0258037","HMDB0037846","HMDB0001066","HMDB0039971","HMDB0251222","HMDB0000012","HMDB0247291","HMDB0060069","HMDB0304209","HMDB0000661","HMDB0266311","HMDB0302150","HMDB0273978","HMDB0028718","HMDB0000912","HMDB0002927","HMDB0000245","HMDB0001894","HMDB0003882","HMDB0039323","HMDB0012815","HMDB0000210","HMDB0257848","HMDB0248272","HMDB0037843","HMDB0255309","HMDB0029092","HMDB0244977","HMDB0034554","HMDB0030406","HMDB0003141","HMDB0029064","HMDB0028825","HMDB0011106","HMDB0252828","HMDB0303673","HMDB0002015","HMDB0060351","HMDB0029072","HMDB0012245","HMDB0012884","HMDB0000215","HMDB0033143","HMDB0000851","HMDB0028871","HMDB0029125","HMDB0000522","HMDB0004808","HMDB0060471","HMDB0302255","HMDB0246029","HMDB0242312","HMDB0038423","HMDB0015066","HMDB0041717","HMDB0253169","HMDB0303639","HMDB0028852","HMDB0260312","HMDB0000230","HMDB0000738","HMDB0000303","HMDB0000929","HMDB0255154","HMDB0037976","HMDB0006485","HMDB0037690","HMDB0000005","HMDB0000355","HMDB0015271","HMDB0039928","HMDB0041015","HMDB0000238","HMDB0030179","HMDB0000085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