MetaboLights

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ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14430/m_MTBLS14430_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14430/m_MTBLS14430_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14430/s_MTBLS14430.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14430/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14430/a_MTBLS14430_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14430/a_MTBLS14430_LC-MS_positive_reverse-phase.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14430Following database searching and metabolite annotation, the overall quality of metabolomics raw data was evaluated. In metabolomics research, the quality of mass spectrometry raw data is mainly assessed from three perspectives:Reproducibility of QC samplesQuality control (QC) samples were prepared by pooling all test samples in equal proportions prior to LC-MS analysis. To assess errors derived from mass spectral signal drift, a QC sample was inserted at regular intervals throughout the batch analysis. High reproducibility among QC samples indicates good instrumental stability. The reproducibility of QC samples was evaluated via PCA plots and QC correlation plots. A correlation coefficient greater than 0.8 was considered to indicate reliable instrument stability.Intra-group sample reproducibilityIntra-group reproducibility reflects the stability of biological replicates. Generally, good intra-group consistency ensures more reliable identification of differential metabolites and better predictive performance of subsequent statistical models. Intra-group reproducibility was judged by the clustering degree of biological replicates in PCA plots and the correlation coefficients in sample correlation analysis. However, this criterion is only for reference, owing to the unstable abundance of metabolites, easy degradation of certain compounds, and large individual biological variation.Inter-group sample differentiationAccording to the experimental grouping, PCA and correlation analysis were used to evaluate the degree of inter-group differences. Typically, clearer group separation in PCA and lower inter-group correlation coefficients suggest more distinct biological differentiation, which further results in a higher proportion of differential metabolites among all annotated metabolites. This evaluation criterion is greatly influenced by sample type and experimental design.MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phaseThe liquid chromatography-tandem mass spectrometry (LC-MS/MS) system for metabolomic analysis consists of a Waters Acquity I-Class PLUS ultra-high performance liquid chromatograph coupled with a Waters Xevo G2-XS QTOF high-resolution mass spectrometer. The analytical column used was an Acquity UPLC HSS T3 column (1.8 μm, 2.1 mm × 100 mm) purchased from Waters [3].Positive ion mode (POS):Mobile phase A: 0.1% formic acid in water;Mobile phase B: 0.1% formic acid in acetonitrile.Negative ion mode (NEG):Mobile phase A: 0.1% formic acid in water;Mobile phase B: 0.1% formic acid in acetonitrile.The injection volume was 2 μLXMulti-omics reveals zearalenone-induced hepato-intestinal injury and growth dysregulation in largemouth bass (Micropterus salmoides).Zhejiang Sci-Tech UniversityChenming Leilivermass spectrometry assaySolid sample:(1) Weigh 50 mg of the sample, add 1000 μL of internal standard-containing extraction solution (methanol:acetonitrile:water = 2:2:1, v/v/v; internal standard concentration: 20 mg/L), and vortex for 30 s to mix thoroughly.(2) Add steel balls, homogenize with a tissue grinder at 45 Hz for 10 min, then perform ice-bath ultrasonication for 10 min.Largemouth basshttps://www.ebi.ac.uk/metabolights/MTBLS14430Chenming Lei. Zhejiang Sci-Tech University. College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China. lcm2001916111@163.com.Raw data acquired by MassLynx V4.2 were processed using Progenesis QI for peak picking, peak alignment and other data pretreatment procedures. Metabolite identification was performed based on the online METLIN database embedded in Progenesis QI, public databases, and the internal self-built database of Biomarker Technologies, with simultaneous recognition of theoretical fragment ionsZearalenonelcm2001916111@163.comLargemouth bass (initial body weight 2.82 ± 0.09 g) were purchased from Foshan Huopo Aquatic Breeding Co., Ltd (Guangdong, China). A total of 600 juvenile fish were randomly allocated to three groups, namely the control (Con), LZ and HZ groups, with five replicate tanks per group (40 fish per replicate, and each tank contained 450 L of water). The juvenile fish were fed to apparent satiation twice daily at 08:30 and 17:30, respectively. During the 28-day subchronic exposure period, key water quality parameters were monitored and maintained at the target ranges: water temperature at 24.0 ± 2.0 °C, pH at 7.6–8.0, dissolved oxygen above 6.0 mg/L, total ammonia nitrogen below 0.4 mg/L. Following the 28-day feeding trial, juveniles were fasted for 24 h and then anesthetized with tricaine methanesulfonate (MS-222, 50 mg/L). All surviving fish were collected to determine final body weight (FBW), which was subsequently used to calculate growth-related indices including weight gain rate (WGR), specific growth rate (SGR), condition factor (CF), and hepatosomatic index (HSI), along with feed efficiency-related indices including the feed intake (FI), feed conversion ratio (FCR) (see formulae in Table S1). Immediately after dissection, liver and midgut samples (5 samples per group) were fixed in 10% neutral buffered formalin for histological assessment. Whole blood (5 samples per group) was collected from the caudal vein using EDTA-coated tubes and stored at 4℃ for subsequent immune-related enzyme activity assays. Hepatic tissues (sourced from the same fish used for immune-related enzyme activity assays) were homogenized in ice-cold 0.9% physiological saline (1:9, w/v) to prepare tissue homogenates for antioxidant capacity determination. Furthermore, midgut tissues (derived from the fish used for immune-related enzyme activity assays) were preserved in RNAlater™ (Thermo Fisher Scientific, Waltham, MA, USA) at 4 °C for subsequent qRT-PCR analysis and the quantification of intestinal epithelial tight junction protein levels, while the residual intestinal contents were snap-frozen in liquid nitrogen and stored at −80 °C for microbiome and metabolome profiling.MetabolomicsMetabolomicsWaters ACQUITY UPLC I-Class PLUS SystemWaters Xevo G2-XS QTofliveruntargeted analysisZearalenonepooled samplelargemouth bassuntargeted metabolite profilingexperimental sampleMetabolomicsWaters ACQUITY UPLC I-Class PLUS SystemWaters Xevo G2-XS QTofliveruntargeted analysisZearalenonepooled samplelargemouth bassuntargeted metabolite profilingexperimental sampleThe Waters Xevo G2-XS QTof high-resolution mass spectrometer was operated in the MSe mode under the control of the acquisition software (MassLynx V4.2, Waters) for the acquisition of primary and secondary mass spectral data. In each data acquisition cycle, dual-channel data acquisition can be performed at low and high collision energies simultaneously. The low collision energy was set to off, and the high collision energy ramp ranged from 10 to 40 V with a scan rate of 0.2 s per spectrum. The parameters of the ESI ion source were set as follows [3]:(1) Capillary voltage: 2500 V (positive ion mode) or −2000 V (negative ion mode);(2) Cone voltage: 30 V;(3) Ion source temperature: 100 ℃;(4) Desolvation gas temperature: 500 ℃;(5) Cone gas flow rate: 50 L/h;(6) Desolvation gas flow rate: 800 L/h;(7) Mass-to-charge ratio (m/z) acquisition range: 50–1200TRYPTOPHAN ETHYL ESTERPlantagoninep-Mentha-1,3,5,8-tetraene2',4',5'-Trihydroxybutyrophenone2',3'-Cyclic UMPMG(0:0/18:1(11Z)/0:0)indole-3-acetyl-tyrosineDacarbazineEctoinePE(22:0/20:4(5Z,8Z,11Z,14Z)-OH(20))Ethoxybenzyl diethylenetriamineN-Valerylglycine methyl esterAypgkfProstaglandin H11,2,3,4,5,6-Hexahydro-5-(1-hydroxyethylidene)-7H-cyclopenta[b]pyridin-7-oneProstaglandin H21-MonostearinCyclooctatin20alpha-HydroxycholesterolMatsutakeside IN-[3-hydroxy-1-{[3.4.5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}octadec-4-en-2-yl]hexadecanamideMethanofuran(2R)-O-Phospho-3-sulfolactate3-Methylthiopropyl-desulfoglucosinolatePG(16:0/20:3(5Z,8Z,11Z))CDP-DG(a-21:0/18:1(12Z)-O(9S,10R))Kinetensin 4-72-Methyl-1-PyrrolineN-[1-{[3.4-dihydroxy-6-(hydroxymethyl)-5-{[3.4.5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-3-hydroxyoctadec-4-en-2-yl]tetracosanamideLimonexic acidMelilotussaponin O1HovenolactoneNCGC00347620-02_C22H34O4_7-Oxabicyclo[4.1.0]hept-3-ene-2,5-diol, 4-(hydroxymethyl)-1-[(1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl-1-naphthalenyl)methyl]-1-Methyl-1,2,3,4-tetrahydroisoquinoline(6R,8Z)-6-Hydroxy-3-oxotetradecenoic acid5b-Cholestane-3a,7a,12a,23S,25-pentol1-(1,3-Benzodioxol-5-ylcarbonyl)piperidineSarmentosin4,6-Dihydroxy-2-mercaptopyrimidineNorthienamycinNorcocaine6-MethylquinolineDigitoxigenin bisdigitoxidealpha-Fluoro-beta-alanineLamivudineL-phenylalanyl-L-prolinePC(24:1(15Z)/24:1(15Z))23S,25,26-Trihydroxyvitamin D3dTDP-D-mycaminose(1R,6R)-6-Hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylateThromboxane1-[2-Methyl-3-(methylthio) allyl]cyclohex-2-enol6''-O-Carbamoylkanamycin APC(18:1(9E)/0:0)[U]Gualenate (Sodium Gualenate)Hydroxyprolyl-LysineProstaglandin C2(+)-4,11-Eudesmadien-3-one1,3-DiisopropylbenzeneAvadomide(2S,2'S)-Pyrosaccharopine2-(4-Methylphenyl)propanalDiplodiatoxinEstradiol-17beta2-Methylpiperidinehexadecan-6Z,11Z-dien-1-ol7,10-Hexadecadiynoic aciddTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucoseGentamicin BProteacinPC(P-16:0/PGE1)N-Docosahexaenoyl GABAPC(22:5(4Z,7Z,10Z,13Z,16Z)/PGE2)PG(i-12:0/a-17:0)Androsterone glucuroniden,n',n''-triacetyl-chitotriose7-Hydroxy-2,5-dimethyl-4H-1-benzopyran-4-oneProstaglandin A2beta-Ionone3-epi-6-DeoxocathasteronePA(16:0/0:0)[cyclic]Leu Glu ThrDihydroactinidiolideent-16b,19-Kauranediol 19-acetateIsoleucyl-LeucineCitrusin IIIEflornithineDesglucocorolosidecurcumin 4'-O-beta-D-gentiobiosyl 4''-O-beta-D-glucosideGlutathione episulfonium ionOleanolic acidPropanoyl phosphateSphingosine3b,12a-Dihydroxy-5a-cholanoic acidMethionyl-Cysteine7',8'-Dihydro-8'-hydroxyreticulataxanthinD-Fructose 1,6-bisphosphatesn-Glycero-3-phosphoethanolamine4-Carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate12-MethyltridecanalBotryodiplodin(E)-octadec-9-en-12-ynoic acidN-UndecanoylglycineCarbamazepine-o-quinoneBestatin20alpha,22beta-DihydroxycholesterolOblongolidePC(16:0/O-1:0)[U]5-(3,4-Dimethyl-5-pentylfuran-2-yl)pentanoylcarnitine2-MethylcyclododecanoneAngiotensin (5-7)S-(2-Hydroxyethyl)glutathione(E)-2-Octen-1-olPhenylacetaldehydeD-pipecolate9Z,12Z-OctadecadienalAla-Thr-Trp-Leu-Pro-Pro-ArgErythrono-1,4-lactoneFosetylHerculinDescladinose roxithromycinTyrosyl-ValineIbuprofen glucuronideFructoselysineBursin3-Carbamyl-(3'-picolyl)-4-methoxy-1-benzamideParoxetine2,2,6,7-Tetramethylbicyclo[4.3.0]nona-1(9),4-dien-8-onePetroselinic acidC16 SphinganineHalovir AMethylajoeneSafynolMycarose1-(2-Furanyl)-2-propanone1-O-Octadec-9-enyl glycerolMonomethyl phthalate2-ThiocytidineEvobioside(3Z)-Phytochromobilin5,6-DihydrouridineMaleamic acid2-(1-Pentenyl)furanBenzeneacetonitrileTyr Leup-cresol7-Hydroxybutylidenephthalide 7-(6-malonylglucoside)(1(10)E,4E,6a,8b)-8-Angeloyloxy-14-oxo-1(10),4,11(13)-germacratrien-12,6-olide2-Chloro-L-phenylalanineSN38 glucuronideDL-Valine-4-antipyrineamideN,N'-Dicyclohexylurea3-MethylethcathinoneN-[4-(Benzylamino)-3-cyanoquinolin-2-yl]-4-methoxybenzamide1,25-Dihydroxy-16-ene-23-yne-vitamin D32-(Fluoromethyl)-3-(3,4-dihydroxyphenyl)alanine4-Fluoro-L-threoninePsilostachyinAbscisic acid glucose esterDihydroclavaminic acid(23R)-Acetoxytomatineval-leu-pro-val-pro-glnRumenic acidThyrotropin releasing hormone7alpha-HydroxycholesterolMG(0:0/22:4(7Z,10Z,13Z,16Z)/0:0)Hydroxy-gamma-sanshoolPS(16_0_20_4(5Z,8Z,11Z,14Z))H Type II trisaccharideRepinotanTHYMOPENTIN1-(2-Furanyl)-1-propanoneAquifoliunine EIIButyryl-L-carnitineOrnithylamphotericin methyl esterPhysostigmine2-Octenoic acidMilbemycin A4BoceprevirlythramineMethyl dioxindole-3-acetateMaltolL,L-Cyclo(leucylprolyl)1alpha,3beta,22R-Trihydroxyergosta-5,24E-dien-26-oic acid 3-O-b-D-glucoside 26-O-[b-D-glucosyl-(1->4)-6-acetyl-b-D-glucosyl-(1->2)-6-acetyl-b-D-glucosyl] esterNebramycin 5PGD2 ethanolamideJanthitrem CJanthitrem BStyrene-cis-2,3-dihydrodiolIsoleucylproline2,12-Tetradecadiene-4,6,8,10-tetrayneSurfactin DTalinumoside I8-Amino-7-oxononanoic acid1-(Methylthio)-1-hexanethiolTrp LeuFalcarindiolAvocadenofuranUbiquinone-6PE(22:1(13Z)/LTE4)MergeptaSoquinolol3-(Acetyloxy)-2-hydroxypropyl octadecanoate6-(alpha-D-Glucosaminyl)-1D-myo-inositolCalcitriolLicorice glycoside A5-Hexyltetrahydro-2-oxo-3-furancarboxylic acidMG(0_0_20_4(5Z,8Z,11Z,14Z)_0_0)Nordihydroguaiaretic AcidMG(0:0/22:5(4Z,7Z,10Z,13Z,16Z)/0:0)3a,7a,12a-Trihydroxy-5b-cholestan-26-al2-Propyl-2,4-pentadienoic acidChenodeoxycholylcitrullineDopamineSucrose 1',4'-(4,4'-dihydroxy-3,3'-dimethoxy-b-truxinate)DihydrolipoateLurbinectedinDesmethylondansetronBiotin sulfoneINOSINE 5'-MONOPHOSPHATExi-3-(4-Isopropylphenyl)-2-methylpropanalPantothenate6-Kestosealpha-VetivoneMethyl fluoroquinoloneCinnamaldehydeCuminaldehyde2-PentadecylfuranCalamusenoneUnknown 3702-Hydroxybiphenylgly-argOxandroloneApigenin 6-C-arabinosyl-8-C-glucoside(2xi,4xi)-2,4-Nonadien-1-olCassiaside CCDP-4-dehydro-3,6-dideoxy-D-glucoseAllotetrahydrodeoxycorticosterone2-PhenylaminoadenosinePC(18:4(6Z,9Z,12Z,15Z)/0:0)N-Eicosapentaenoyl Tyrosine2-Methoxy-1,4-benzoquinonePG(16:0/18:1(12Z)-2OH(9,10))PC(P-18:1(11Z)/PGJ2)6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1b'' aglyconeGentamicin C1aAcetylvalerenolic acidMethymycinDG(16:0/18:1(11Z)/0:0)gamma-Glutamyl-gamma-aminobutyraldehyde1,2-Benzisoxazole2,6-PipecoloxylidideMiglustatp-CoumaroylagmatineD-Glucosaminate-6-phosphate3,5,7-Trimethyl-2E,4E,6E,8E-decatetraeneSalanninInecalcitolUndecylenic acidHyoscyamineCrepenynatePectacholBioside3-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dionealpha-Amylcinnamyl formate4-Methyl-1-phenyl-2-pentanol16,16-dimethyl-PGA1Thymidine glycol1-(11Z-docosenoyl)-glycero-3-phosphatesphingosine (d17-1)5Z,13Z-Docosadienoic acidRizatriptanCyclic ADP-riboseTulathromycin ADaumone5-O-beta-D-MycaminosyltylactoneBiliverdin-IX-delta4,5-octadienoylglycineCarrageenan, potassium salt of2-MethylbutylamineGDPSanfetrinem2,4-Diaminobutyric acid3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestaneStearamidea-L-Arabinofuranosyl-(1->3)-[a-L-arabinofuranosyl-(1r5)]-L-arabinose1,2-Dihydro-1,1,6-trimethylnaphthaleneElocalcitol(2R)-N-[(2S)-1-[[(2S)-5-(Diaminomethylideneamino)-1-(heptylamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamidePremazepam9-HydroxyNonadecanoylcarnitinethiazolinedioneL-alpha-Acetyl-N-normethadolUroporphyrin IV(+-)-CarbovirPrometrynParatocarpin G6-Amino-N-[6-keto-6-(6-ketohexylamino)hexyl]hexanamide(E)-2-Butenyl-4-methyl-threonineGlcNAcMan3GlcNAc2-I3'-O-methyluridineDG(20_0_14_0_0_0)8-Deoxy-11,13-dihydroxygrosheiminHis Gly GlyOxymesterone3-Ethyltoluenealpha-Amylcinnamyl acetateN-Desmethylrosuvastatinδ-Tridecalactone7-Mercaptoheptanoic acidL-PyrrolysineEthyl 2,4-dioxohexanoateCholineTetrahydro-2-furanmethanolPolyglycerol esters of fatty acidsPC(22_4(7Z,10Z,13Z,16Z)_P-18_0)LiriodendrinEthyl N2-acetyl-L-argininateN-VinylpyrrolidinequinoneimineL-IsoleucineN-Acetyl-N-[(2S)-3-(1H-indol-3-yl)-2-[[2-(4-piperidin-1-ylpiperidin-1-yl)acetyl]amino]propyl]-2-methoxybenzamideLevanbioseAB-MECAPrenol6-Oxopiperidine-2-carboxylic acidC20916(S)-Chiral alcohol(-)-Epigallocatechin 3-p-coumaroateEremopetasinorone A2-(6-hydroxyhexyl)-3-methylidenebutanedioic acid2,4(1H,3H)-PyridinedioneGeranylhydroquinone1-MethylpyrroliniumFasoracetamLysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)UlinastatinFumiquinazoline F-indoline-2',3'-diolisopropyl unoprostone3'-Hydroxystanozolol7alpha-Hydroxy-3-oxo-4-cholestenoate(2R,3R)-3-Methylornithinyl-N6-lysine3-(4-Hydroxyphenyl)-1-propanolColistin(1alpha,4beta,5beta)-4-Hydroxy-7(11),10(14)-guaiadien-8-onePedein BCerebronic acidNarbomycinlpe(0-0_20-4)Mdpbp3-HydroxybutyrylcarnitinePA(22:5(4Z,7Z,10Z,13Z,16Z)/20:3(6,8,11)-OH(5))3-Oxooctanoic acidMaltoheptaoseThreonylvalineGypsogenin 3-O-b-D-glucuronideCasokefamide3,4-DihydroxyphenylacetaldehydePhenylgalactoside2,4,6,8,10-dodecapentaenal1-Palmitoyl-sn-glycero-3-phosphocholine3beta-Hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-4alpha-carboxylateDethiobiotin2-Acetyl-1,5,6,7-tetrahydro-6-hydroxy-7-(hydroxymethyl)-4H-azepine-4-one2'-O-methylguanosineStemmadenine2-Aminoethylphosphocholatebeta-D-Gentiobiosyl crocetinCyclopropanecarboxylic acidLefamulin2-Cyclotetradecen-1-oneLysoPC(20:2(11Z,14Z))LysoPC(18:3(9Z,12Z,15Z)/0:0)D-1-[(3-Carboxypropyl)amino]-1-deoxyfructose3-Isovalidene-3alpha,4-dihydrophthalide(5Z,7E,9E,14Z,17Z)-IcosapentaenoateBenzyladenine 3-O-beta-D-glucosideMelatonin glucuronideN-Acetyl-leu-leu-leu-tyr-amideOsmundalin4-GuanidinobutanoateCysteine sulfinateOenanthoside APorrigenin A2-Methylbenzoic acidCDP-DG(PGF1alpha/20:4(5Z,8Z,11Z,14Z))Prostaglandin E2 methyl esterPolyoxyethylene 40 monostearateHercyninePA(22:4(7Z,10Z,13Z,16Z)/LTE4)PentahomomethionineFlurithromycin2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide5-Acetamidopentanoate4alpha-Carboxy-stigmasta-7,24(24(1))-dien-3beta-ol2,2,6,6-Tetramethyl-4-piperidinoln-arachidonylethanolamineKainic AcidDinitrophenyl-lysine4-MethylaminobutanalOleic acidMG(0:0/22:5(7Z,10Z,13Z,16Z,19Z)/0:0)BismahanineDicyclomineArg Gly ValEugenyl benzoatemeso-Tartaric acidLys Gly4-Hydroxy-6-methyl-3-(1-oxobutyl)-2H-pyran-2-oneDMPOGalactocerebroside3',5'-Dideoxythymidine1-Palmitoyl Lysophosphatidic AcidLinatineTiglylcarnitine8-Amino-8-demethylriboflavin 5'-phosphatePE(16:0/0:0)Octocrylene3-Hydroxyhexadecanoylcarnitineprostaglandin a1 ethyl ester17-Hydroxymethylethisterone2-(2-Furanyl)-3,4,5,6-tetrahydropyridineIsovaleric acidCarboxyfentanylTetradecanolThreoninyl-LysineAmphibine BDG(20_5(5Z,8Z,11Z,14Z,17Z)_18_1(11Z)_0_0)1,8-Dihydroxy-3-methylnaphthaleneHelenalin15-HEPE(-)-α-Cedrene12(S)-HPETE7alpha,27-Dihydroxycholesterol2,3-Dihydro-6-methyl-5-propanoyl-1H-pyrrolizinePregnanoloneAcetyljujuboside BDEACETYLGEDUNINNe-Methyl-L-lysineAndersolineNorbicycloekasantalal2-epi-5-epi-ValioloneDG(i-14:0/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15)/0:0)PentadecanalMurolic acidexo-2-Methyl-3-methylenebicyclo[2.2.1]heptan-2-ol11,12-Dimethoxy-8,11,13-abietatrien-20,7-olide3,5-Dimethylpyrazole3-MethylcyclohexanolC16 SphingosineDelmopinolDihydroceramide C21,10-dihydro-1,10-dihydroxyfluoren-9-oneIsoketocamphoric acidPerulactoneMycosporine serinoldTDP-L-olivoseBupivacainen-methyl-2-(4'-methylaminophenyl)-6-hydroxybenzothiazoleGlutarylcarnitineTryptophyl-TryptophanhexanoylcarnitineAngiotensin IIGlycochenodeoxycholate2,3,6-TrimethylphenolPELLETIERINE8E,10E-Tetradecadienal2-Amino-4-oxo-6-(1',2'-dioxoprolyl)-7,8-dihydroxypteridineTetracosahexaenoic acid, n-3Dexanabinol9-peroxy-5Z,7E,11Z,14Z-eicosatetraenoateCycloheximideAcetylcarnitineOxepinAcoric acidBrivanib alaninateLentialexin6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1a'' aglyconeTriethylaminelpc(0-0_22-6)11'-Carboxy-gamma-chromanolArginyl-Gamma-glutamateAsparagoside A9-cis-retinal3,4,5-trihydroxy-6-{3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenoxy}oxane-2-carboxylic acid3,6,8-TrimethylallantoinHydroxypentobarbitalFolinic acidSpectinomycinIsopentenyladenosine-5'-diphosphate9,10-Epoxy-18-hydroxystearateEmindole SB1-Acetoxy-2-hydroxy-5,12,15-heneicosatrien-4-oneUDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-glucose3'-N-Debenzoyltaxol3E,4Z,7,11-Tetramethyl-6,10-tridecadienalL-Cyclopentylglycineβ-nonylenic acid3,3'-Di-tert-butyl-5,5'-dimethoxybiphenyl-2,2'-diolN-Methyl-1-deoxynojirimycinPA(10:0/20:5(5Z,8Z,11Z,14Z,16E)-OH(18R))Semilepidinoside Bmonophospho-n-acetylneuraminic acidPalustradienalCyclooctyne3-Phenyl-2-propenyl1-Linoleoylglycerophosphocholine5b-Cholestane-3a,7a,12a,23-TetrolNorpandamarilactonine AOleandrinCyclolinopeptide ACyclolinopeptide BMG(0:0/16:0/0:0)DesacetylvinblastinePreisocalamendiolN-(2-Hydroxypropyl)valine2-ThiohydantoinN-stearoyl serineLysoPE(20:3(5Z,8Z,11Z)/0:0)PG(22:5(4Z,7Z,10Z,13Z,16Z)/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15))xi-4-Hydroxy-4-methyl-2-cyclohexen-1-oneDopamine quinoneAsp Val His Arg4,4alpha,5,6-Tetrahydro-7-methyl-2(3H)-naphthalenoneZeinoxanthin4-OctylphenolTetraazacyclododecanetetraacetic acidBetaine(E,E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl propionateTyrosyl-LysineFormylfusarochromanoneN-Acetyl-O-demethylpuromycin-5'-phosphateS-(9-hydroxy-PGA2)-glutathione3-Methyl-1-phenyl-3-pentanol(S,E)-2-(5-Hydroxy-8,9-dihydro-5H-benzo[7]annulen-6(7H)-ylidene)acetic acidN(alpha)-Acetyl-L-2,4-diaminobutyrate1-Heptanol3-Methylbutan-1-ol(10R,13R,17R)-3-Hexadecoxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene2-acetyl-1,4,5,6-tetrahydropyridine3-Quinolinecarboxylic acid, 7-((3R)-3-(1-aminocyclopropyl)-1-pyrrolidinyl)-1-((1R,2S)-2-fluorocyclopropyl)-1,4-dihydro-8-methoxy-4-oxo-Phorbol myristate3-Dehydro-2-deoxyecdysoneIsoquinoline6-DeoxocathasteroneHomostachydrineDigitoxigenin 3-[glucosyl-(1->6)-glucosyl-(1->4)-2,6-dideoxyribohexoside]Avermectin B1b monosaccharideKetorolacSanteneLYNESTRENOLMisoprostol(S)-gamma-Calacorene4alpha-formyl-ergosta-7,24(241)-dien-3beta-olAsparaginyl-LeucinePC(22:5(4Z,7Z,10Z,13Z,16Z)/24:0)RutacridoneGlutamyl-S-allylcysteinePegorgotein7Z-Octadecen-11-oneErythromycin BErythromycin DARECOLINE3-[(2-Benzyl-3-sulfanylpropanoyl)amino]propanoic acidEstriol 3-sulfate 16-glucuronidea-L-Arabinofuranosyl-(1->3)-b-D-xylopyranosyl-(1->4)-D-xylose7-Hydroxy-2',5,6-trimethoxy-4',5'-methylenedioxyisoflavone 7-(2-p-coumaroylglucoside)1-Oleoyl-sn-glycero-3-phospho-D-myo-inositol(1-)His Tyr Gln Thr[(2S,3R)-2-Amino-3-hydroxybutanoyl] (2S)-pyrrolidine-2-carboxylatebeta-Solaninetrans,trans-Farnesyl phosphateNorcotinine7-O-Demethyl Rapamycin5-HydroxyindolepyruvateFusarin CJubanine ABisacumolNetilmicinDapdiamide B2E,4Z-OctadienalCohibin ALysoPC(22:4(7Z,10Z,13Z,16Z)/0:0)StyreneCortisol 21-acetate3-Hydroxy-4,6-heptadiyne-1-yl 1-glucoside3-HydroxyhexadecadienoylcarnitinePE-NMe2(22:5(4Z,7Z,10Z,13Z,16Z)/24:1(15Z))1-Nonadecanoyl-glycero-3-phosphoserine5-Oxoavermectin ''1a'' aglyconeD-Glutamine4-HydroxyphenylglyoxylateWithaperuvin D6''-O-CaffeoylastragalinVigabatrin3-oxostearic acidN-Arachidonoyl Glutamic acid1',2'-Dihydro-1,1'-dimethyl-2'-oxo-4,4'-bipyridinium(1+)CDP-DG(i-20:0/PGF1alpha)S-Formylglutathione(R)-4'-Phosphopantothenoyl-L-cysteine3-Methyl sulfoleneBakuchiolRetigabine3-HydroxyheptadecanoylcarnitineMacrophorin D(Z)-[(4-hydroxyphenyl)acetaldehyde oxime]HydrocinchonineDG(21:0/LTE4/0:0)Neocuscutoside C3,4-Dimethyl-5-propyl-2-furanpentadecanoic acidLeucylproline1-Methyl-1,3-cyclohexadienePG(22:5(4Z,7Z,10Z,13Z,16Z)/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4))Galabiosylceramide (d18:1/24:1(15Z))cis-3,4-LeucopelargonidinN-AcetylisoputreanineBucolomeDesmethyl rizatriptan2-n-Propylthiazolidine-4-carboxylic acidLysoPC(18:3(6Z,9Z,12Z)/0:0)phenylethylamide 3311-Phenyl-1-cyclohexene11Z-Eicosenoic acidpe(22-6(4z,7z,10z,13z,16z,19z)_p-16-0)o-XylenePentadecylamineO-(13-Carboxytridecanoyl)carnitineIsoleucylhydroxyprolineAciclovirtetraethylene-glycol(-)-3-Carene3-Hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoyl-CoAPE(P-16:0/18:3(10,12,15)-OH(9))LysoPE(0:0/18:3(6Z,9Z,12Z))MG(0:0/22:0/0:0)HydroxyamobarbitalHimbacine9-methanesulfinylnonanoic acid(1(10)E,4a,5E)-1(10),5-Germacradiene-12-acetoxy-4,11-diolMyristic acid2-PhenylethanolOctopamine (p-Hydroxyphenylethanolamine)DG(16:0/18:2(9Z,12Z)/0:0)3,11,12-Trihydroxy-1(10)-spirovetiven-2-one2,2,4,4,6,6-Hexamethyl-1,3,5-trithiane4-DeoxypyridoxineRhizocticin A(-)-BetonicineRibostamycingamma-L-GlutamylputrescineRetinol / Retinol skeletonMdp-gdp3-Des(dimethylaminoethyl)-3-acetic acid zolmitriptan8-[(1R,2R)-3-Oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoatePyrenophorolThreoninyl-Tryptophan2,3-Dihydrowithanolide ELysoPC(16:0/0:0)12,15-epoxy-13,14-dimethyleicosa-12,14-dienoic acid5α-Androst-16-en-3α-olAnofinic acid1-Methyl-L-histidineLevonordefrinMETENEPROSTN5-formyl-N5-hydroxy-L-ornithineIsohumbertiolSM(d16:2(4E,8Z)/20:4(5Z,8Z,11Z,14Z)-OH(20))ImazodanLividomycin BMelibioseTussilagine9,12,15-Octadecatrien-1-ol(7R,E)-8-((1S,Z)-1-hydroxy-1-methylhexahydro-2H-quinolizin-3(4H)-ylidene)-4,7-dimethyloct-4-en-3-oneCholestane-3,7,12,25-tetrol-3-glucuronideFusarochromanoneMethyl 1-methylpyrrole-2-carboxylateMaltotriose3-Hydroxy-4-oxo-4H-pyran-2-carboxylic acidPressinoic acidGlycyl-histidyl-arginyl-prolineMG(18:1(9Z)/0:0/0:0)[rac]NicotinamideN-Lactoylleucinen6,n6-dimethyladenosine5β-CHOLANIC ACID-3α, 12α-DIOL N-(2-SULPHOETHYL)-AMIDEL-Menthyl (R,S)-3-hydroxybutyrate6-HydroxymelatoninOxytetracyclineAntheraxanthinTridemorphBis(glutathionyl)spermine disulfideMILTEFOSINE3''-OxoribostamycinAscorbigenO-propanoyl-carnitinePE-NMe(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))2-Isopropylfuran2,5-Dihydroxybenzamide3-O-alpha-Mycarosylerythronolide BDG(14:0/PGJ2/0:0)Stearoyllactic acid1-[(5-Amino-5-carboxypentyl)amino]-1-deoxyfructoseMangalkanyl glucosidePentenylbenzeneHis Gly Val ThrPhthalic acid Mono-2-ethylhexyl Ester5-Heptadecyl-1,3-benzenediolPranidipinePalmyramide APC(16:0/0:0)[U] / PC(16:0/0:0)[rac]PE(18:4(6Z,9Z,12Z,15Z)/P-16:0)1-Hydroxypyrene glucuronide7,8-Dehydro-3,4-dihydro-beta-ionol1-Pentanol1,1-Difluoroethane7-MethylxanthosineN-Acetyl-L-citrulline1,2,5,6-Tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-oneHeptanal2,6-Dihydroxy-3-cyanopyridineNonatePhloretic acid2E,9-Decadienal2-(5-Methyl-2-furanyl)-3-piperidinolHistidinyl-Lysine3-(2-HYDROXYPHENYL)PROPANOATEnostopeptolide A1Pseudaminic acid7-Deoxyloganetic alcoholN-Alpha-acetyllysineGalactosylglycerolMethionyl-LysineDisialosyl galactosyl globoside2-Isopropyl-1,4-hexadieneThonzylamineIle Gly ProSpirolide ESpirolide BSpirolide D4-HydroxybenzylamineAminofurantoinPIRACETAMO-Arachidonoyl GlycidolTerfenadineEpipodophyllotoxin derivitive4a-HydroxytetrahydrobiopterinEtonogestrel5-Phospho-alpha-D-ribose 1-diphosphatetomatidine5,7-Megastigmadien-9-ol glucoside2'-Deamino-2'-hydroxyneamineOndansetron(7b,10a)-3-Hydroxy-1,3,5-cadinatrien-9-one(3R,4R,5R)-3-Fluoro-5-(hydroxymethyl)oxolane-2,3,4-triolTabunNicotinamide-beta-ribosideSolanidineXestoaminol CHumulinic acid A6-Lactoyl-5,6,7,8-tetrahydropterinMesoridazineAndrostenediol dipropionatePolidocanolTerpentecinCitrulline2-Amino-4-ethoxy-3-hydroxybutanoic acid(2S,3R)-2-Amino-4-octadecene-3-ol2-methyl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypyran-4-oneMaduropeptin chromophoreEnol-phenylpyruvate18-Carboxy-dinor-LTE4N-VINYL-2-PYRROLIDONECervonyl carnitine2,6-DihydroxynaphthaleneNeopterinPA(8:0/5-iso PGF2VI)V-Pyrro/NO(3Z)-PhycocyanobilinMarindininTrihexosylceramide (d18_1_18_0)Dihydroneopterin phosphateDemethoxycurcuminCyanosulfurous acid anionArginylglutamineGlutathione12,13-DHOMEPhenylalanylserinePlicamycin5,8,11-Eicosatriynoic AcidEthylcyclohexane1-Monopalmitin2-Methyl-5-propyloxazole5,6,7,8-tetrahydro-2-Naphthoic AcidOleamideNaphthalene dihydrodiolPG(a-15:0/LTE4)1b,3a,7a-Trihydroxy-5b-cholanoic acid5alpha-CholestanolN5-(4-Methoxybenzyl)glutamine7-Methylguanosine 5'-phosphateEstradiol-17beta 3-glucuronideChromanePrunin 4'',6''-di-O-gallateTaxine B2,6-nonadienoic acidL-OrnithineMyrcenePiperideine13-DocosenamidePC(18:3(6Z,9Z,12Z)/24:1(15Z))AsparaginylisoleucinePG(18:1(12Z)-O(9S,10R)/i-12:0)tetrahydropyridoindolePhthalic acid(R)-Carvotanacetone6-MethylcoumarinBenzyl alcoholGlutathionylaminopropylcadaverine(±)-AegelinePI(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/PGE2)1-(9Z-Nonadecenoyl)-glycero-3-phosphoethanolamineMethylpicraquassioside A1-Octadecanoyl-sn-glycero-3-phosphoethanolamine1-Deoxy-11-oxopentalenateTovophyllin AEvocarpine1,8-Menthadien-2-ol1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycero-3-phosphatebk-MDDMA5-Ribosylparomamine(S)-2,3-Dihydro-3,5-dihydroxy-2-oxo-3-indoleacetic acid 5-[glucosyl-(1->4)-b-D-glucoside]Dibutylamine7-Aminobenzo[d]isothiazol-3(2H)-one 1,1-dioxideSphingosine 1-phosphate (d19:1-P)GlutaminylarginineTRIOXIFENEPro Pro Arg ThrAminoimidazole ribotideDhurrin 6'-glucosideN(alpha)-Benzyloxycarbonyl-L-leucineAtropaldehydegenipinCyclo(-D-Tyr-Arg-Gly-Asp-Cys(carboxymethyl)-OH) sulfoxideProlylglycineMethyl (3b,11x)-3-Hydroxy-8-oxo-6-eremophilen-12-oate1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycero-3-phosphoethanolamineGaboxadolPunctaporonin B5-Phenylvaleric acidTriamcinolonePS(O-16:0/13:0)Sebacoyl-L-carnitineStearidonic acidBenzenebutanoic acid, alpha-(acetylamino)-2-amino-gamma-oxo-PhenforminGlycidyl oleateAuraminecis-1,2-Dihydroxy-1,2-dihydro-7-methylnaphthalenePyrethrosin9-HOTE(1-Ribosylimidazole)-4-acetateL-cis-3-Amino-2-pyrrolidinecarboxylic acidMG(19:0/0:0/0:0)LysoPI(18:2(9Z,12Z)/0:0)beta-D-glucosaminyl-(1->4)-beta-D-glucosamine2-Amino-2,3,6,7-tetrahydro-1H-pteridin-4-oneTetrahydropersin10-DeoxymethymycinHeptaminolLicorice glycoside D1UmbelliferoneSagittariolGuanineCMP-N-trimethyl-2-aminoethylphosphonate3,4-Epoxy-6Z,9Z-eicosadieneRifampicin4-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylateN-AcetylserinePhenmetrazine3-methylheptanedioylcarnitineCDP-DG(a-21:0/PGF1alpha)1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diolC17 SphinganineCL(10:0/11:0/11:0/13:0)5-Phenyl-1,3-pentadiynedGMPThr Arg His ThrL-ArogenateRimantadineOctadecanol6'''-Deamino-6'''-hydroxyparomomycin IILysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z))Lepidiumterpenyl esterVolicitinCellotetraoseTokinolide BCDP-DG(i-19:0/i-24:0)DG(16:1(9Z)/18:1(9Z)/0:0)[iso2]Glycerol phenylbutyrate3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-algamma-HumuleneGlutamyl pyruvateStachyoseGlutethimide9-Oxononanoic acidURSINIC ACIDAntibiotic X 14889Abeta-Alanyl-L-argininePhenylalanylargininePralnacasanRosifoliolN1,N5,N10-Tris-trans-p-coumaroylspermine3-(4-Methylphenyl)oxiranecarboxylic acidCinnamyl butyrateL-GlutamateN2-Ethyl-2'-deoxyguanosineCys Ser Ser CysEcgonine methyl esterDihydrocorynantheineEntecavirResiquimodMenthol1-Oleoyl-rac-glycerolColforsin daropatetrioxyethylene dimethacrylate(E)-3-(4-Tert-butylphenylsulfonyl)acrylonitrileL-3-Aminodihydro-2(3H)-furanone4-Aminobutanoate9,10-DiHOME4-Oxofenretinide22-Hydroxydocosanoic acidEthyl 3-hydroxydodecanoatePL(+/-)-Methyl 5-acetoxyhexanoateZymosterolEpothilone DZalcitabineLeukotriene F4Creatine ribosideGeldanamycin2-[5-[2-[2-[5-(2-hydroxybutyl)oxolan-2-yl]propanoyloxy]butyl]oxolan-2-yl]propanoic acidlys-met(E)-4,8-Dimethyl-1,3,7-nonatrieneCyclomarin A3-Methyl-1-(2,4,6-trihydroxyphenyl)-1-butanoneD-Glucosaminide3-Hydroxymethyltriazolopthalazinone glucuronide(1R,4R,4'R,5S,5'S,6R,6'S,7R,9R,11R,12R,13S,14S)-12-[(3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-4-ethyl-5,5',6,11-tetrahydroxy-4'-methoxy-4',5,6',7,9,11,13-heptamethylspiro[3,15,17-trioxabicyclo[12.4.0]octadecane-16,2'-oxane]-2,8-dioneVinblastine(10S)-Juvenile hormone III diol2,3-MethylenedioxymethcathinoneAminomethyl fluoresceinPC(14:0/0:0)Leu-Leu-LeuDopamine glucuronide1,5-Bis(4'-glucopyranosyloxy-3'-hydroxyphenyl)pent-4-en-1-yne(±)-OctanoylcarnitinePsma-hbed-CCPC(2:0/20:4(5Z,8Z,11Z,14Z)-OH(20))Perilloside BPC(P-18:0/PGE1)Lippioside ILucidenolactonedTMPValidoxylamine A13-Dihydrodaunorubicin2-Propylsuccinic acidN-Oleoyl HistidinePhorbol7-MethylhypoxanthineAzacridone ALysoPE(0:0/22:2(13Z,16Z))3-HydroxylidocainedCMPCholesterolNeomycin BPC(P-16:0/18:1(12Z)-2OH(9,10))Tenuazonic acidval-lys4-(2,6,6-Trimethyl-1-cyclohexenyl)-2-butanolPG(PGJ2/i-19:0)L-cis-4-(Hydroxymethyl)-2-pyrrolidinecarboxylic acid6-Ethyl-4-methyl-3E,5E,7E-decatrieneTunicamycin AAlosetronMG(0:0/22:2(13Z,16Z)/0:0)2-IsopropylmaleateTunicamycin I4-Amino-6,7-dimethoxy-2-(1-piperazinyl)quinazolineSphingosine 1-phosphateLactodifucotetraose4-Methyl-1-phenyl-2-pentanoneN-[(3a,5b,7b)-7-hydroxy-24-oxo-3-(sulfooxy)cholan-24-yl]-GlycineCytosineb-D-Glucopyranosiduronic acid, (3a,5b)-24-[(carboxymethyl)amino]-24-oxocholan-3-yl3-Amino-1-(3-(cyclohexylmethoxy)phenyl)propan-1-olOleylcarnitineCalcitetrol7-benzyl-11,14-dimethyl-16-(2-methylpropyl)-10,13-di(propan-2-yl)-17-oxa-1,5,8,11,14-pentazabicyclo[17.3.0]docosane-2,6,9,12,15,18-hexoneDeoxyguanidinoproclavaminic acidFuranogermenone4-Amino-anhydrotetracyclineC18-OH Sulfatide6'-Dehydro-6'-oxoparomaminePro Asn Pro GluAlliofuroside A7,8-Dihydro-7,8-dihydroxykynurenateIreneCarboxymethyl chitosan5-Ethyl-3-methyl-2E,4E,6E-nonatrieneHomocarnosineNCGC00380639-01_C38H62O10_NCGC00169248-02_C22H34O5_7-Oxabicyclo[4.1.0]hept-3-ene-2,5-diol, 4-(hydroxymethyl)-1-[[1,4,4a,5,6,7,8,8a-octahydro-5-(hydroxymethyl)-2,5,8a-trimethyl-1-naphthalenyl]methyl]-(4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,1 6,19-Docosahexaenoic acid3'-Methyl-2',4',6'-trihydroxydihydrochalconeOxidized Latia luciferin3beta,7alpha-Dihydroxy-5-cholestenoateCDP-DG(18:0/22:3(10Z,13Z,16Z))Docosahexaenoyl PAF C-16MG(0:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)Tryptophyl-PhenylalanineGeranyl hexanoateAnthranilateHistamine-betaxanthinArabinosylhypoxanthineN-Fructosyl isoleucylglutamateGentamicin C24-HydroxyindoleAminoacetoneTerpendole G10-Oxooctadecanoic acidFinrozole(±)-IbuprofenEthylbenzenePE-NMe(13D5/13M5)Citrunobin9-O-Acetylneuraminic acidVitamin D3 / Cholecalciferol (Vitamin D3) skeletonPE(18:1(9Z)/0:0)delta-Elemene7,8 Dihydrokawain1,2-Cyclohexanedicarboxylic acidD-Glycero-D-galacto-heptitolBenzenebutanoic acid6E,8E,12E,14E-Hexadecatetraen-10-ynoic acidPI(20:5(5Z,8Z,11Z,14Z,17Z)/0:0)3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al2-Hydroxycyclopent-2-en-1-oneBENZYDAMINEFarfugin AN,N-dimethyl-Safingol1-fluorocyclohexadiene-cis,cis-1,2-diolPergolideTetrahydropentoxylinePhysalin OErythro-9-hydroxy-nonyl-adenineProclavaminic acidErgothioneinePalmitoyl EthanolamideBuspirone N-oxideLysoPE(0:0/22:0)2-Methyl-2H-1,3-benzoxazin-4(3H)-one1-(11Z,14Z-eicosadienoyl)-glycero-3-phosphateEthionamide(24E)-3alpha,15alpha-Diacetoxy-23-oxo-7,9(11),24-lanostatrien-26-oic acidPHENACYLAMINEMG(0:0/18:2(9Z,12Z)/0:0)Ginsenoyne JCalamendiolHymenoxonPE(20:5(5Z,8Z,11Z,14Z,17Z)/0:0)8-Methylthiooctyl-desulfoglucosinolateDeacetylcephalosporin CO-Acetylcarnitine3'-C-Ethynylcytidine1,2-dihydrostilbeneBardoxolone methylVal Phe3,7-Dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamideLysoPI(18:1(9Z)/0:0)epsilon-Deoxy-fructosyl-lysine11-trans-LTC4trans-4-Aminocyclohexanecarboxylic acidIndolinedTDP-4-amino-2,4-dideoxy-beta-L-xyloseβ-PHENYL-gamma-Aminobutyric AcidPC(18:0/18:4(9E,11E,13E,15E))PHENYLACETOHYDROXAMIC ACIDPhe Gly Ile Pro2,6-dimethyl-2-octeneN-(3-oxo-hexanoyl)-homoserine lactoneDelta4-Dafachronic acidIncadronic acidLysoPC(22:5(4Z,7Z,10Z,13Z,16Z))3,9,15-Tribenzyl-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexoneIlaprazoleGladiatoside B3SedoheptuloseN-(4-Methoxyphenyl)-all-trans-retinamideAscladiol2-AminoheptanoateNCGC00381156-01_C24H30O6_Methyl 3-[(1E,3E)-3,5-dimethyl-1,3-heptadien-1-yl]-8-hydroxy-6a,8-dimethyl-6-oxo-6a,8,9,9a-tetrahydro-6H-furo[2,3-h]isochromene-9-carboxylate4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine10-Deacetylbaccatin IIIPiperidineArginyl-GlutamineColnelenic acid2-Feruloyl-1-sinapoylgentiobiose8-Isoquinoline methanamine (hydrochloride)PhosphocholineParomamineFluoroacetatePhenethylamine glucuronide2,3,6,7-Tetrahydro-7-methylcyclopent[b]azepin-8(1H)-oneMG(0:0/18:3(9Z,12Z,15Z)/0:0)(2S,3R,E)-2-Amino-4-tetradecene-1,3-diolIsoeugenyl acetateLPE 18_2Chenodeoxycholylphenylalanine1,2,4-Benzotriazin-3-amine 1-oxideNCGC00385388-01_C21H34O11_(1R,4S,7S,8S,9R,12E,20R,21R,22S,23S)-7,8,21,22,23-Pentahydroxy-12,16-dimethyl-3,5,10,19,24-pentaoxatricyclo[18.3.1.0~4,9~]tetracos-12-en-11-one(2S,3R,5R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(2R,3R,5R)-2,3,6-trihydroxy-5,6-dimethylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-oneIsopropyl beta-D-glucosideL-Pipecolate2,6-Diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo(3,2-d)pyrimidin-4-oneJuvenile hormone IIIGlu Pro ProIsofucosterol 3-O-[6-O-(9,12-Octadecadienoyl)-b-D-glucopyranoside]Pyridoxine-5'-phosphatevalinomycinTranylcypromine glucuronidePGF2α Alcohol methyl etherO-Succinyl-L-homoserineTyrosylhydroxyprolineProlylmicrocystin RR1-Naphthylmethanolarachidonoylethanolaminealpha-Corocalene2-MethylbutyroylcarnitineTridecanolMithramycinBialaphosNonacosanoic acid3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dioneOctanoylglucuronidePGF2a ethanolamide5-Hydroxyindoleacetic acidPteroyltriglutamic acidPG(i-12:0/18:1(12Z)-O(9S,10R))alpha-AmylcinnamaldehydeGingerglycolipid Balpha-MethylstyreneAcetylenic acids; 17-Octadecen-9-ynoic acidMethyl helicterateHydralazine pyruvate hydrazoneL-Olivosyl-oleandolide6-Methoxymusizin 8-O-[b-D-glucopyranosyl-(1->6)-b-D-glucopyranosyl-(1->3)-b-D-glucopyranosyl-(1->6)-b-D-glucopyranoside]7,8-Dihydro-2'-deoxyguanosineMisoprostol (free acid)Quinoline-4,8-diolhydrocinnamic acidcis-4-Carboxymethylenebut-2-en-4-olide3alpha-Hydroxy-3,5-dihydromonacolin L acid1-PiperidinecarboxaldehydeAllomaltol8,8a-DiepiswainsonineLysoPC(18:0/0:0)L-Formylkynurenine2-Ethylhydracrylic acidLysoPE(16:1(9Z)/0:0)PenbutololBenzoic anhydridePC(DiMe(13,5)/PGJ2)Vitamin D3Icosenoic acid(E)-5,8-Megastigmadien-4-one(R)-1-O-[b-D-Glucopyranosyl-(1->6)-b-D-glucopyranoside]-1,3-octanediolS-(2-Carboxyethyl)-L-cysteineDihydro-3-coumaric acidTetradecanoylcarnitineNCGC00381119-01_C13H22O6_2-Furanacetic acid, tetrahydro-alpha-methyl-5-(2-oxopropyl)-, 2,3-dihydroxypropyl esterCotinine glucuronideOR-1896N,N-DimethylsphingosineFMLPm-XyleneAlaceprilCDP-DG(PGJ2/a-15:0)(R)-11,12,13-Trinor-1(5),6,9-guaiatrien-8-one3-Methyl-2,5-furandioneN-Glycoloyl-neuraminate5-Hydroxy-3,4-dihydrocarbostyrylCalcipotriolL-Homocysteic acidAbt-510DG(14:0/20:1(11Z)/0:0)(E,E)-2,4-HexadienalHydroxyhomodestruxin BDecanoic acidDehydrosafynol1-Octen-3-yl glucosideValyl-Proline1-[5-(2-Cyclopropyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)thiophen-2-yl]cyclopent-3-ene carboxylic acidFlumethasone Pivalate25-Hydroxy-6,19-dihydro-6,19-ethanovitamin D3Agavoside A2-(10-heptadecenyl)-6-hydroxybenzoic acidMedicagenic acid 28-O-[b-D-xylosyl-(1->4)-a-L-rhamnosyl-(1->2)-a-L-arabinosyl] esterL-Ascorbic acid4-Acetyl-2-methylpyridineCorchorusoside AIndanone6'''-Deamino-6'''-oxoparomomycin IIAdafosbuvirAla Tyr Lys4-HydroxycoumarinArachidonateLysoPC(16:1(9Z))(Z)-3-Nonen-1-olCinnamyl formate1H-Pyrido[3,2-c][1,2]diazepineGlyceraldehyde phosphateHistidinyl-Tryptophan2,4-UndecadienalDelapril2-Methyl-1,3-cyclohexadieneCDP-DG(6 keto-PGF1alpha/i-12:0)1,2,3,4,5,6-Hexahydro-7H-cyclopenta[b]pyridin-7-oneGlyzarin4-hydroxybenzoateSpermidine2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one4-hydroxy-5-[2-[(E)-3-hydroxyprop-1-enyl]-4-methylphenyl]-3-methylhexan-2-one(1R,6R)-1,4,5,5a,6,9-Hexahydrophenazine-1,6-dicarboxylateAdenosine, 8-(butylamino)-N-cyclopentyl-4(1H)-Pyridinone, 2-ethyl-3-hydroxy-1-(2-hydroxyethyl)-CholylasparaginePRIMA-1(2R,4S)-2-Aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dionep-Mentha-1,3,8-trieneNCGC00381144-01_C15H24O2_(4S,4aR)-4-(Hydroxymethyl)-3,4a,8,8-tetramethyl-4a,5,6,7,8,8a-hexahydro-1(4H)-naphthalenoneMetanephrinelpc(22-4_0-0)Pro Pro Pro(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-17-((2R)-6,7-dihydroxy-6-methylheptan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triolPC(O-22_0_22_6(4Z,7Z,10Z,13Z,16Z,19Z))Zearalenone4E,8-NonadienalN-(4-Aminobutyl)-N-ethylisoluminolepsilon-(Hexanoyl)lysine5-hydroxy,3E-sphingosine3-MethylcyclopenteneCAY10444DG(13:0/PGE2/0:0)2-Hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate1-EthylaziridineCyclo(D-Trp-D-Asp-Pro-D-Ile-Leu)13-Tetradecene-1,3-diyne-6,7-diolCreatinine4-VinylcyclohexeneAbrineN-Acetylneuraminic AcidRifabutinLicheninDG(14_0_16_0_0_0)PE(24:0/22:6(4Z,7Z,10Z,13E,15E,19Z)-OH(17))Glycolithocholic acid7',8'-Dihydro-8'-hydroxycitraniaxanthinZidovudineMirogabalinPC(DiMe(11,5)/22:6(5Z,8E,10Z,13Z,15E,19Z)-2OH(7S, 17S))IcofungipenPalmitic amideBUFEXAMACLysoPE(20:2(11Z,14Z)/0:0)1-Ipomeanol1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamide5-Methyldeoxycytidine2-Oxo-10-methylthiodecanoic acidPro Gln Leu Asp5-FluorouridinePacific Ciguatoxin 4ABulleyaconitine AAtractylodin2,3-octadienoylglycine4-O-Methyl-a-D-glucosyl-(1->2)-b-D-xylosyl-(1->4)-D-xylose24,25-Diacetylvulgaroside4E,6E,10Z-Hexadecatrien-1-olDalbergin2-(2-Furanyl)-3-piperidinolDehydrovomifoliolN-Acetyl-2,6-diethylaniline3β-Hydroxy-19-oxochol-5-en-24-oic AcidLysoPE(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)CrotanecinePG(i-12:0/PGE1)2-HeptadecylfuranAtorvastatinTryptopholRevefenacin13-Demethylspirolide CEthenodeoxyadenosineHydroxyprolyl-Valine(9Z,12Z,15Z)-Octadecatrienoic acidNCGC00380976-01_C28H42N2O7_(4E,10E)-13,20-Dihydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(22),4,10,18,20-pentaen-9-yl carbamateMertansinePropylene glycol alginateDexelvucitabineHonyudisinLysoPE(P-18:0/0:0)SphinganineBax inhibitor peptide V5Methyl Phenylglyoxalate2-HexylidenecyclopentanoneMetoprololVinylacetylene12-Methyl-13-tridecanolideAmylopectinFuro(3,4-b)pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxo-, ethyl ester(R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pent-2-enoic acidOleoyl Ethyl AmideFarnesyl acetoneTridecanal1-(1-Methylethenyl)-4-(1-methylethyl)benzeneFurost-5-ene-3beta,22,26-triolPE(24:0/20:5(6E,8Z,11Z,14Z,17Z)-OH(5))LysoPE(0:0/18:0)(3xi,5Z)-1,5-Octadien-3-olEmbelin5'-Hydroxy-3'-methoxysativanLysine conjugated cholic acid4-Amino-1-[(1S,2S,4S)-4,5-bis(hydroxymethyl)-2-bicyclo[3.1.0]hexanyl]pyrimidin-2-one2-Oxo-2,3-dihydrofuran-5-acetateGlutathionylspermidine(R)-2-(4-(Tert-butoxycarbonyl)morpholin-3-yl)acetic acidCoagulin R 3-glucosidealpha-Terpineol propanoateLiquiritigenin 4'-[3-acetylapiosyl-(1->2)-glucoside]PI(PGJ2/16:0)Nystatingly-gly-phe20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acidNCGC00385331-01_C31H44O12_(2E)-3,7-Dimethyl-2,6-octadien-1-yl 3-O-(6-deoxy-alpha-L-mannopyranosyl)-4-O-[(2E)-3-(4-hydroxyphenyl)-2-propenoyl]-beta-D-glucopyranosideAdrenochrome o-semiquinonedTDP-acarviose-7-phosphate2,6-DimethylquinolinePC(O-15:0/O-1:0)[U]Desferrioxamine D15-FormiminotetrahydrofolateDopaquinoneOleoylcholinePE(20:5(5Z,8Z,11Z,14Z,17Z)/24:1(15Z))L-Histidinol1,2-DisinapoylgentiobioseNCGC00381448-01_C15H24O5_1-Naphthalenecarboxylic acid, 1,4,4a,5,6,7,8,8a-octahydro-1,4-dihydroxy-2-(hydroxymethyl)-5,5,8a-trimethyl-6-Ethylchenodeoxycholic acidSulfapyridineFeruloylputrescineAsparaginyl-Gamma-glutamatePedunculosideFrovatriptanN-Benzoyl-L-tyrosine ethyl esterPanaxydiolMonoisobutyl phthalic acid(15a,20R)-Dihydroxypregn-4-en-3-one 20-[glucosyl-(1->4)-6-acetyl-glucoside]13,17-Octadecadiene-9,11-diynoic acid, (Z)-1H-Indole-4-acetic acid, 2,3-dihydro-2-oxo-1,8-Diazacyclotetradecane-2,9-dioneDeoxyuridineAsp Leu Trp TrpPA(17:1(9Z)/0:0)allo-Protolichesterinic acid6-Hydroxydec-6-enedioylcarnitineTapentadolTocopheronic acidPE(15:0/20:2(11Z,14Z))5-Hydroxymethyl-2-furancarboxaldehydeN-AcetylmannosamineValylisoleucineN1-(alpha-D-ribosyl)-5,6-dimethyl-benzimidazole1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholineD-4'-PhosphopantothenateCarmofurGanglioside GM3 (d18:0/14:0)Cortolt-4-AMINOCROTONIC ACID (TACA)beta-FunaltrexamineIndoleacrylic acidNovapikromycinN-Isopropyl-p-toluamidePro Asp Asp LysN-acetyl zonisamideisoxazolyl penicillin2,6-nonadienalCMP-pseudaminic acid17alpha,20alpha-Dihydroxypregn-4-en-3-one(3E,5E)-1,3,5-octatriene2-(2-Thienylmethylene)-1,6-dioxaspiro[4.4]non-3-ene(3beta,22R,23R,24S)-3,22,23-Trihydroxystigmastan-6-one2-(5,8-Tetradecadienyl)cyclobutanoneMozenavirLinamarinRIOPROSTILTetrahydrofurfuryl butyratelys-tyrL-ArginineETHYL 1-BENZYL-3-HYDROXY- 2-OXO[5H]PYRROLE-4-CARBOXYLATE(S)-3-(Azetidin-2-ylmethoxy)pyridine2-ArachidonoylglycerolIslatravirD-Pipecolic acid2,3-Dihydro-5-(5-methyl-2-furanyl)-1H-pyrrolizineDocosahexaenoyl EthanolamideGibberellin A20PG(i-12:0/PGJ2)1-NitroheptaneCyclo((2R)-2-aminobutanoyl-N2-methyl-L-arginylglycyl-L-alpha-aspartyl-3-(aminomethyl)benzoyl)3-Methyl-2-(1-pyrrolidinyl)-2-cyclopenten-1-oneGRK2 Inhibitor4(5)-EpDPE methyl ester13,14-Dihydro PGE1N-Glycolyl-D-glucosamineLysoPE(0:0/20:4(5Z,8Z,11Z,14Z))Prostaglandin F2a-d94,6-Decadiyn-1-olCapsi-amide(4-{4-[2-(gamma-L-Glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine5-carboxycytidineCholesterol glutamateGentamicin A sulfate3E,7-Dimethyl-1,3,6-octatrieneTrihexosylceramide (d18_1_16_0)3,5-Dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one3,5,7-Trimethyl-2E,4E,6E,8E-undecatetraeneRetinoyl-AZT(±)-(Z)-2-(5-Tetradecenyl)cyclobutanoneHovenidulcigenin ACaffeineEctocarpenGlyceryl monolinoleateSoyasaponin IHydroxypropionylcarnitinegamma-GlutamylcysteineVanylglycolSarpogrelate4-MethylbiphenylN-Hydroxynorcocaine1-Hydroxy-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-2-phosphocholineAntipyrineDG(19:0/PGE2/0:0)PE-NMe(16:1(9Z)/22:5(4Z,7Z,10Z,13Z,16Z))2-Amino-1,3-eicosanediol3-Hydroxy-9-hexadecenoylcarnitinePlazomicin(+)-Vulgraon BOzagrelAklaviketoneMalptllPeanut oil, hydrogenatedPI(22:4(7Z,10Z,13Z,16Z)/6 keto-PGF1alpha)PE(20:0/PGE1)Dibutyl sulfide2-methylidene-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybutanoic acidPS(19:1(9Z)/22:4(7Z,10Z,13Z,16Z))Coenzyme BCyclocreatineFilfilineL-2-Amino-3-methylenehexanoic acidBetaine aldehydeGlycine xylididemorpholinoChavicol4-Fluorocyclohexane-1-carboxylic acidDL-KavainAlanylisoleucine3-Isochromanone6-Fluoropyridoxal4-Amino-3-hydroxybutanoylcarnitine1-MethylnaphthalenePyridoxamine phosphate2',4',6',3,4-Pentahydroxy-3'-geranyl-5-prenyldihydrochalcone4'-Methoxybenzophenone-2-carboxylic acidlpc(20-0_0-0)Tanshinone IIA5,7-Dihydroxy-3,6,8,4'-tetramethoxyflavone 7-glucosyl-(1->3)-galactosideile-lys3'-Prenylapigenin 7-[rhamnosyl-(1->6)-glucoside]trans-isoeugenol-O-glucuronideLysoPC(6:0/0:0)ThymidineN-Methylmyosmine2-MethylerythritolPE(P-16:0/18:1(12Z)-2OH(9,10))Oleandomycin3-methyl-1-heptenePhytocassane D8-(Methylthio)octanenitrileLysoPE(18:2(9Z,12Z)/0:0)MG(0:0/18:0/0:0)Glu PheNitrosylsulfuric acid2-PiperidinoneFevicordin B 2-[rhamnosyl-(1->4)-glucosyl-(1->6)-glucoside]1400WdIDP5,7,8-Trihydroxyflavanone 7-glucosideBenzaldehydem-Coumaric acidTecastemizoleAcremoauxin AMelleinTetracycline4-Oxo-1-(3-pyridyl)-1-butanoneGly HisAvermectin B1a2-(Arabinosylamino)-3-(glucosylamino)propanenitrileCholylphenylalanine(16R,17R)-3-Cyclopentyloxy-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-16,17-diol5,7-Diethyl-9-methyl-3E,5E,7E,9E-tridecatetraene5'-Deoxyadenosine(R)-Pterosin B2-Oxo-5-(3,3-dimethylguanidine-1-yl)pentanoic acidAsp Asp AspN-palmitoyl serineN-AcetylbialaphosRaffinosePC(P-18:1(11Z)/PGE2)3-MethylcytidineNCGC00386029-01_C14H20O8_2-Hydroxy-4-(2-hydroxyethyl)phenyl beta-D-glucopyranoside3-Amino-2,3-dideoxy-scyllo-inososeMG(18:0/0:0/0:0)Milbemycin beta2TolueneZotarolimuslasalocidDeoxycytidineValylprolinegamma-Glutamylglycine1-BenzazepineBiopterinLeonoside APC 34_0falseXMulti-omics reveals zearalenone-induced hepato-intestinal injury and growth dysregulation in largemouth bass (Micropterus salmoides)Zearalenone (ZEN), a prevalent Fusarium-derived mycotoxin in plant protein-based aquafeeds, poses severe threats to farmed aquatic animals. However, its toxic effects and underlying mechanisms on the commercially critical largemouth bass (Micropterus salmoides) remain largely uncharacterized. Here, juvenile M. salmoides were fed diets containing 0, 100, and 1000 μg/kg ZEN for 28 days. Growth performance, hepato-intestinal histopathology, barrier function, and antioxidant/biochemical parameters were systematically determined, combined with 16S rRNA sequencing and untargeted metabolomics to elucidate ZEN’s toxic mechanism. Dietary ZEN induced biphasic growth dysregulation: low-dose ZEN significantly promoted fish growth, while high-dose ZEN impaired feed efficiency, caused severe oxidative damage, histopathological lesions, and tight junction gene downregulation in the liver and intestine. ZEN exposure drastically disrupted intestinal microbial homeostasis, reduced core commensal bacteria, enriched potential pathogens, and disturbed host metabolic pathways related to nutrient transport, amino acid/lipid metabolism, and inflammatory response. This study revealed that ZEN induced growth dysregulation and hepato-intestinal injury in M. salmoides via disrupting gut microbial and metabolic homeostasis, providing novel insights into ZEN toxicology in carnivorous fish and theoretical support for mycotoxin control in aquaculture.2026-05-052026-05-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