MetaboLights

application/xml

ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14435/m_MTBLS14435_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14435/m_MTBLS14435_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14435/s_MTBLS14435.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14435/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14435/a_MTBLS14435_LC-MS_positive_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14435/a_MTBLS14435_LC-MS_negative_reverse-phase.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14435For metabolite identification, the raw data were searched against metabolite databases using Progenesis QI software by matching MS and MS/MS spectral information with the databases. The main databases used included public databases such as http://www.hmdb.ca/ and https://metlin.scripps.edu/, as well as an in-house database.MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phaseThe LC-MS analysis was performed on an AB SCIEX ultra-performance liquid chromatography coupled with triple time-of-flight mass spectrometry (UPLC-TripleTOF) system. Chromatographic separation was conducted on a BEH C18 column (100 mm × 2.1 mm i.d., 1.7 μm; Waters, Milford, USA). Mobile phase A consisted of water containing 0.1% formic acid, and mobile phase B consisted of acetonitrile/isopropanol (1:1, v/v) containing 0.1% formic acid. The gradient elution program was as follows: 0–3 min, 0–20% B; 3–9 min, 20–60% B; 9–11 min, 60–100% B; 100% B was maintained for 2.5 min; 13.5–13.6 min, 100% to 0% B; and 0% B was maintained for 2.4 min. The flow rate was set at 0.40 mL/min, the injection volume was 20 μL, and the column temperature was maintained at 40°C.Integrated transcriptomic and metabolomic analysis reveals insights into drought stress in Plantago lanceolata.Yunnan Academy of Agricultural Sciencesliqiong lileafmass spectrometry assayPrecisely weigh an appropriate amount of sample, then add 400 µL of cold methanol solution (methanol:water = 4:1, v/v). Disrupt the sample using a high-throughput tissue grinder at low temperature. After vortex mixing, perform ultrasonic extraction on ice for 10 minutes, repeated three times. Then, place the sample at -20°C for 30 minutes. Centrifuge at 13,000 × g for 15 minutes at 4°C. After centrifugation, transfer the supernatant to an LC-MS vial with an insert for subsequent analysis.Plantago lanceolatahttps://www.ebi.ac.uk/metabolights/MTBLS14435Before statistical analysis, raw data were subjected to a series of preprocessing steps. The raw data were imported into the metabolomics processing software Progenesis QI (Waters Corporation, Milford, USA) for baseline filtering, peak detection, integration, retention time correction, and peak alignment. Subsequent data preprocessing was performed to generate the final data matrix for downstream analysis.Treatment614997870@qq.comThe mixed tissue of the fourth leaf was collected, immediately placed into cryogenic vials, frozen in liquid nitrogen, and stored at -80°C.MetabolomicsThermo Scientific Vanquish UHPLC SystemMetabolomicsPlantago lanceolataAB SCIEX QTRAP 6500+untargeted analysisexperimental blankdrought stress response traitleafFlavonoiduntargeted metabolite profilingThermo Scientific Vanquish UHPLC SystemMetabolomicsPlantago lanceolataAB SCIEX QTRAP 6500+untargeted analysisexperimental blankdrought stress response traitleafFlavonoiduntargeted metabolite profilingMass spectrometric data acquisition was performed in both positive and negative ion scanning modes. The electrospray capillary voltage, sampling voltage, and collision voltage were set at 1.0 kV, 40 V, and 6 eV, respectively. The ion source temperature and desolvation temperature were maintained at 120°C and 500°C, respectively. The carrier gas flow rate was 900 L/h. The mass scan range was 50–1000 m/z, and the resolution was set at 30,000.3'-HydroxymethylrocaglateTrp-Asp-AspPhenylacetylglutamineEdulisin IArg-Asp-AspPhe-IleAsn-Ser-Leu2-O-CaffeoylarbutinBensulfuron-methyl1-Hexanol arabinosylglucosideRickinic acid ACaryatin glucosideAnhydrocinnzeylanineArg-Glu-Ile3,4-dihydroxyphenylglycolCitrusin FCitrullineCitrusin DAsperulosideGlucoconringiinH disaccharideGly-Pro-ArgAlbocyclineTyr-IleMonic acid2-Phenylethyl 6-O-alpha-L-lyxofuranosyl-beta-D-galactopyranosideUlmosideP-Anisic AcidPantoyllactone glucoside(2E,6Z)-8-beta-D-glucopyranosyloxy-2,6-dimethyl-2,6-octadienoic acid7-(5,7-dimethoxy-4-oxochromen-2-yl)heptanoic acidQuercetin 3-O-glucuronideChrysoeriol3alpha-Androstanediol glucuronideO-Methyl-4-[(2',3',4'-tri-O-acetyl-alpha-L-rhamnosyloxy)benzyl]carbamateDigitoxigenin bisdigitoxideMussaenosidic acidEbracteatoside BSambunigrinGlyceryl methylmethacrylateFMNH2Luteolin 7-glucuronosyl-(1->2)-glucuronide6,9-Octadecadienedioic acidFluocortolone PivalateGravelliferoneN-Formylantimycic acid methyl esterPrunin 4'',6''-di-O-gallateDgmg(18:3)1,2-O-Isopropylidene-D-glucofuranosePosatirelinCarbenicillin indanylShikimic acidImidazotetrazine3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)pentanoic acid2-hydroxycinnamic acidHerdmanine CGlyantrypine1-palmitoyl lysophosphatidic acidEseramineVanillic acidPhe-GluAlpha-guaiaconic acid2-O-Glucosyloxy-4-Methoxycinnamic Acid3-Dehydroquinic acidAquilegioside G2'-hydroxypyridoxolBetamethasone 17 ValerateTrp-Gly-Asp17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide)3-(3-methoxy-3-oxoprop-1-en-2-yl)oxybenzoic acidProtochlorophyllideUlimorelinHC Blue No. 2L-glycero-D-manno-HeptoseCis-2-Carboxycyclohexyl-acetic acidIsocitric acidArg-Ser-ProVitexin 6''-O-malonyl 2''-O-xyloside2-Hydroxynevirapine4-dodecylbenzenesulfonic acidD-LysopineNitrendipineGamma-13(s)-hpotreArtocaprin4-(beta-D-glucosyloxy)-3-hydroxy-benzoic acidNorchelerythrine(4S,6R)-p-Mentha-1,8-diene-6,7-diol 7-glucoside5-DeoxylamiolXanthoxylineEupatilinSudan IIIDodecyl-beta-D-maltosideEribaxabanFeruloyl quinic acidTrp-Glu4'-o-(glca(1-2)glca)apigeninOlivil 4'-O-beta-D-glucopyranosideParacetamol sulfateValeant8-OxodeoxycoformycinDMH-1Spionoside BTerephthalic acidCephamycin CGlurosideLinalool 3,6-oxide primeveroside4-Decan-4-Ylbenzenesulfonic AcidN-Eicosapentaenoyl Aspartic acid5,7-dihydroxy-6-(3-hydroxy-3-methylbutyl)-3-(4-hydroxyphenyl)chromen-4-oneFissistin7-Oxoprostaglandin I2PE(5-iso PGF2VI/18:3(9Z,12Z,15Z))Clotrimazole(2E,4E)-8-(beta-D-Glucopyranosyloxy)-2,7-dimethyldeca-2,4-dienedioic acidHumilixanthinMycorradicinMyzodendroneDiasesarteminClindamycinFarnesyl pyrophosphate4'-Methylepigallocatechin1-O-Vanilloyl-beta-D-glucosePrenyl glucosideL-Threonic acidBispyribac1-O-E-Cinnamoyl-(6-arabinosylglucose)Scrophuloside A1Ser-Gln-HisNepetariaside(-)-11-hydroxy-9,10-dihydrojasmonic acid 11-beta-D-glucoside2,3-dihydroxyundecanedioic acidEthyl 1-(4-tert-butylphenyl)-5-cyano-4-methyl-6-oxopyridazine-3-carboxylateDesmethyl Bosentan3-Oxo-alpha-ionol 9-[apiosyl-(1->6)-glucoside]Vanillic acid+o-sulfonatehexN-AcetylisoleucineBeta-D-Glucopyranosyl-11-hydroxyjasmonic acidCitric acidNorgestrel[6]-Gingerdiol 4'-O-beta-D-glucopyranosideCynarosideLipoyl-GMPPhlomisionosideSuspensaside9,10-Epoxy-13-hydroxy-11-octadecenoateHis-Gly-LysVerbascosideMG(6 keto-PGF1alpha/0:0/0:0)PaashaanolactoneQuadranoside IIIFukiic acidAsp-Arg-ThrPersiconinPhe-Val2-O-p-Coumaroylhydroxycitric acidCromoglicic acidAcetyl-Tyr-Val-Ala-Asp-chloromethylketoneIlexhainanoside D7,8-Dihydro-3b,6a-dihydroxy-alpha-ionol 9-[apiosyl-(1->6)-glucoside]Glu-Ala-Ile9-Hydroxynerolidol-9-O-beta-D-glucopyranoside-2'-O-acetateIle-Val4-(beta-D-Glucopyranosyloxy)phenylacetic acidCinnamoylglycineOliceridinePoncirin2,3-Dkpgf1alphaEsculetinCis-(Homo)3-aconitate1-Salicylate glucuronide(4R,5S,7R,11x)-11,12-Dihydroxy-1(10)-spirovetiven-2-one 12-glucosideDehydroascorbic acid2-Octoxy-6-[(3,4,5-trihydroxyoxan-2-yl)oxymethyl]oxane-3,4,5-triolAcuminosideCucurbic acidDukunolide CBisdethiobis(methylthio)gliotoxinMonoethyl Phthalate6''-AcetylliquiritinD-Threo biopterin3-Hydroxy-2,3,4-trimethyl-5-oxooxolane-2-carboxylic acidFluticasoneUrolithin A-8-O-glucuronide6S,9R-Dihydroxy-4,7E-megastigmadien-3-one 9-[apiosyl-(1->6)-glucoside]Phe4Cl-Asp-OHRosiridoside COctadec-9-ene-1,18-dioic-acidGlycyrrhizaisoflavone CCoumaroyl quinic acid(8E,10S,12Z,15Z)-10-Hydroperoxyoctadeca-8,12,15-trienoateBlumenol C glucoside2-Methoxyestrone 3-glucuronide6-Epi-7-isocucurbic acid glucoside5,7-dihydroxy-2-methoxychromen-4-oneCys-Arg-Glu-Lys-Ala9,10-DihomeVicenin 2AspalathinAlpha-D-GalpNAc-(1->3)-[alpha-L-Fucp-(1->2)]-D-Galp14-Methylpentadecanoic acidGln-Asp-ThrMethyl dioxindole-3-acetateBidenoside DFlurbiprofen glucuronide1,4-Diamino-2,3-dicyano-1,4-bis(phenylthio)butadieneSoraphen OTrichlamideHesperetin 7-neohesperidosidePhomopsichalasinBenzyl beta-primeverosideGeldanamycinPteroside QPungeninTyramine glucuronideAsp-Ile-Asp4-Hydroxy-5-(3',4'-dihydroxyphenyl)-valeric acid-O-methyl-O-glucuronidePropyl formate2,5-di-tert-butylhydroquinoneSmilanippin ARhyncoside D8-Amino-7-oxononanoic acidOnonetinHis-PheFeruloylquinic Acid5-Hydroxyindole-3-acetic acidArg-Arg-ArgDaumone 4Ajmalicine3'-Methoxytricetin 7-glucuronidePentoxifyllineGanolucidic acid CLetermovirSalicin3-(2,3-dihydroxypropyl)-6,8-dihydroxyisochromen-1-onePerilloside A9(S)-HpODEPemptoporphyrin2-Methyl-3-oxoadipatePhaeofuran BGlucosyl passiflorate1-O-Sinapoyl-beta-D-glucoseCis-MelilotosideSinapoyl aldehyde1,6,8-trihydroxy-1H,3H-cyclohepta[c]furan-5-oneDimethoxaneLeukotriene D45,6,4'-Trihydroxy-7,3'-dimethoxyflavoneGlu-Lys-Tyr6-C-GlucopyranosyldihydroquercetinTianshic acid methylester(E)-9,10-dihydroxytetradec-6-enedioic acidCystineVal-IleIle-Gly-IleDiphenhydramine N-glucuronideNonioside BChalepin acetateNonactinic acidDomesticosideSulforhodaninAsperuloside acidNep-IN-2FenflumizoleCDP-glycerolVismiaguianin ACaffeic acid hexoside(2R,3R)-2-[3-(3,4-Dihydroxyphenyl)prop-2-enoyloxy]-3-hydroxybutanedioic acidTaxifolin 3-alpha-L-arabinofuranoside3-dehydroshikimateLeu-Ala-GlyScolymosidePitavastatin LactoneCatechin 3'-glucuronide7,8-Dihydro-3b,6a-dihydroxy-alpha-ionol 9-glucoside2,3-Dinor prostaglandin E1Oleoside 11-methyl ester(3R)-1-Octen-3-yl-beta-primeverosideOlradipineAlpha-Linolenic Acid(1alpha,3beta,20S,22R,24S,25S)-PubesceninChrysoobtusin4-Hydroxy duloxetine glucuronideSpongouridinLapaquistat acetateMatairesinosidePlactin DTheogallinXanthoneBenzyl O-[arabinofuranosyl-(1->6)-glucoside]Hexyl glucoside1'-Acetoxyeugenol acetateAgarCatalpol7-ethyl-8-hydroxy-4,7-dimethyl-6-oxo-8H-isochromene-3-carboxylic acidBlumenol C O-[apiosyl-(1->6)-glucoside]4,6-dihydroxy-3-(1-hydroxyethyl)-5-methoxy-3h-2-benzofuran-1-oneGamma-Butyrolactone4-[5-(1-hydroxyethyl)furan-2-yl]-4-oxobutanoic acid3-benzyl-3-hydroxy-6-methoxy-6-(2-methylpropyl)piperazine-2,5-dioneTuberonic acid glucosideVanilpyruvic acidDesglucoparillinDgdg(7:0/18:3)Asn-Ala-IleMjdbissn00000009Paramethasone acetateN-Acetyl-L-phenylalanineLysoPE(18:2w6/0:0)Mgmg(18:3)5-Amino-6-(5'-phosphoribitylamino)uracilMjdbissn00000003Mjdbissn00000001Palmitic acidCaohuoside D3,4-Diferuloylquinic acid2-decenedioic acidSqdg(6:0/3:0)Ala-Gly-LeuDehydroisoandrosterone sulfateSer-Phe4-pentyl-3-(4-pyridyl)-4,5-dihydro-1h-1,2,4-triazole-5-thioneTrinexapac-ethylGlutathione trisulfide12-oxo-2,3-dinor-10,15-phytodienoic acidDendronobiloside BNeuraminic acidSer-Val-IleNimbolideGaylussacin3-hydroxysuberic acid8-Epideoxyloganin2-Benzothiazolsulfonic AcidGlu-Tyr-GlnIle-Gln-TyrThr-LeuKadangustin D6-[4-(2-carboxyethyl)phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid10,16-Dihydroxyhexadecanoic acid(3S,7E,9R)-4,7-Megastigmadiene-3,9-diol 9-[apiosyl-(1->6)-glucoside]Bhos#16LuteolinLucyoside R(2S)-2-Butanol O-[b-D-Apiofuranosyl-(1->6)-b-D-glucopyranoside]Glucoquiritin Apioside7-Propoxy-chromen-2-one(-)-2-Difluoromethylornithine4-Hydroxyphenylacetylglutamic acidBelnacasan5-Methoxysalicylic acidBetavulgarin glucoside(-)-Blastmycinolactol{1-[2-(4-Carbamimidoyl-benzoylamino)-propionyl]-piperidin-4-yloxy}-acetic acidN-AcetylmuramateMonoglutamyl folate(S)-2-Acetamido-3-(4-chlorophenyl)propanoic acidCid 9844747Citronellyl beta-sophorosideUrceolideO-Benzoyl-L-malic acidRandiosideAcacetin3-Hydroxy-3-methylglutaric methyl esterCitroside A3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid4,4'-Methylenebis(2,6-di-tert-butylphenol)Dopaol beta-D-glucosideSwertiamarin3-Isopropyl-4-methyl-2,3-dihydro-1H-pyrrolo[3,4-b]quinoline-1,9(4H)-dioneTrkA InhibitorSucrose laurate(E)-heptadec-6-en-16-yne-1,2,4-triol(Z)-6-methyl-2-(4-methylpent-3-enyl)hept-2-enedioic acidCaryoptosidic acid3,4-dihydroxyphenylpyruvateProtoporphyrin IX12-Sulfooxy-9,10-dihydrojasmonic acidGeranyl beta-D-glucopyranosideCis-zeatin-9-N-glucoside(2S,3R,4S,5R,6R)-6-Ethyloxane-2,3,4,5-tetrolFumaryl diketopiperazine4-Hydroxybenzoic acid glucoside6-Acetyl-D-glucoseColnelenic acidBaicalin(9Z,12Z)-7,8,16-trihydroxyoctadeca-9,12-dienoic acidEverlastoside DCichorioside NCortisol 21-mesylateNb-trans-Feruloylserotonin glucosideN1-trans-FeruloylagmatineHis-ProZiprasidone(E)-4-Methoxystilbene-3,3',5,5'-TetrolAmpelopsin 3'-methyl ether 4'-rhamnosideChemanox 22SericosideChloramphenicol glucuronide5,7-dihydroxy-4-methylcoumarin(E)-2-O-Cinnamoyl-beta-D-glucopyranose10-Hydroxy-8-nor-2-fenchanone glucoside2,3,4,5,6-pentahydroxyhexyl (9Z,12Z)-octadeca-9,12-dienoate5-Hydroxy-L-tryptophanCyclopassifloside VILicoagroside BVanillin(-)-Glyceollin I(3R,4S)-3,4,5-trihydroxy-3,4-dihydro-2H-naphthalen-1-one6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-olBufadienolideEchinacoside6-CaffeoylsucroseDeoxyinosineCoumarinic acidProcumbosideIxerisoside IHippuryl-glycyl-glycineSyringic acid beta-glucopyranosyl esterOenanthoside AN-acetyl-dl-glutamic acidKukoamine AEgonolD-(-)-Quinic acid3'-O-beta-Glucopyranosyl plumbagic acid methyl esterKetologanic acid5-O-Methylembelin4-hydroxyphenyllactic acidDeacetylasperulosidic acidCyclohexa-1,3-diene-1,2-dicarboxylic acid(E)-9,12-dihydroxydodec-10-enoic acidVeronicosidePheophorbide aAngelicoidenol 2-O-beta-D-glucopyranosideMyristyl sulfateUrsolic acid3,4-HexahydroxydiphenoylarabinoseTaraxinic acid glucosyl esterOctanoylglucuronide3-Epicorosolic acidChaetoquadrin FGlucosamineAucubinGingerglycolipid BDemethylvestitol3,3-dimethyl-5-oxo-5-[4-(2-pyrimidinyl)piperazino]pentanoic acidFuraneol 4-(6-malonylglucoside)Amaroswerin4-Megastigmene-6a,9R-diol 9-[apiosyl-(1->6)-glucoside]Chrysin-7-O-beta-D-glucoronideN-[(3a,5b,7a)-3-hydroxy-24-oxo-7-(sulfooxy)cholan-24-yl]-GlycineAustdiolVal-PheBisnoryangoninCarbocyclic 3-deazaadenosineTenuifolinIsoferulic acid(3R,4R)-4,5,8-trihydroxy-3-methyl-3,4-dihydroisochromen-1-oneQuinolactacin ALinatineCistanoside ECasuarinePenbutolol1-(3-Methylbutanoyl)-6-apiosylglucoseCistanoside F4-maleyl-acetoacetateGrevilloside ELinalool oxide D 3-[apiosyl-(1->6)-glucoside]2,3-Butanediol apiosylglucosideDarolutamideEudesmic acidMedicagenic acid base+o-hex1-(3,5-Dihydroxyphenyl)-2-propanoneForsythoside ERutaretin 9-rutinoside(R)-1-O-[b-D-Glucopyranosyl-(1->6)-b-D-glucopyranoside]-1,3-octanediolDextran-70Osmanthuside hNuzhenideCis-2-MethylaconitatePhenmediphamForsythoside b2D-5-O-Methyl-2,3,5/4,6-pentahydroxycyclohexanone6''-O-MalonylglycitinEriojaposide A3-[(3-amino-1h-1,2,4-triazol-5-yl)amino]azepan-2-one4-(1-Hydroxyethyl)benzene-1,2-diolLamiolPenicillic acidUridine2-[[2-(3,5-Dihydroxy-4-isopropyl-phenyl)-2-guanidino-acetyl]amino]acetic acidGlu-Phe8-AcetylegelolidePG(5-iso PGF2VI/20:4(8Z,11Z,14Z,17Z))VicianoseLymecyclineCervonoyl ethanolamideEquolTricoccin s3Isoketocamphoric acidGlucosylxanthoneIsoeugenolIsopropyl apiosylglucosideTestosterone sulfatePyridinolineTyr-Val-Ala-Asp-chloromethyl ketone(3S,5R,6S,7E,9x)-7-Megastigmene-3,6,9-triol 9-glucosideMuco-InositolLiquiritin4-chloro-N-[2-chloro-4-(trifluoromethyl)phenyl]benzenesulfonamideSojagol4-Oxahomoadamantan-5-one12,13-DiHOMELys-Asp-TyrFumagillolSulfamonomethoxineDsletDictamnoside ISakuraninSulfo jasmonateAlpha-L-Rhamnopyranosyl-(1->3)-alpha-D-galactopyranosyl-(1->3)-L-fucosePhenylpyruvic acid3-hydroxyflavoneRyanodine(+/-)9-hodeAurapteneTalaroconvolutin B11-Hydroxy-9-tridecenoic acidC-veratroylglycol3-O-(alpha-L-rhamnopyranosyl)-D-ribitol4-Methoxymelilotic acid3,12-dihydroxydodecanoic acidAscaroside C6HomoisocitrateTigemonamGln-Ile-HisTrans-EKODE-(E)-IbScytalone(2Z)-3-[2-(beta-D-Glucopyranosyloxy)phenyl]acrylic acid2-Dodecylbenzenesulfonic acid3-Methyl-2-butenyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranosideTriethylene glycol diglycidyl etherAla-Val-AlaBungeiside DAbealpha1-3ManalphaButofilololEriodictyol 7-(6-trans-p-coumaroylglucoside)Benzyl alcohol beta-D-rutinosideLeu-Ala-Ile2-glucosyloxy-4-methoxycinnamic acid2-(3-methylbutoxy)-6-[(3,4,5-trihydroxyoxan-2-yl)oxymethyl]oxane-3,4,5-triolChrysoeriol 7-O-(6''-malonyl-glucoside)OdoratoneKaltostatAvicularin2-hydroxyhexadecanoic acidJuglanoside EAstemizoleLevoglucosanTetrahydrofolyl-[Glu](n)VillinolCompactin diol lactoneAsp-Ile-IleAdenosine 2',3'-cyclic phosphatePropofol glucuronideTrichlormethiazidePolyethylene, oxidized5-Hydroxypentanoic acid2,5-Diaziridinyl-3,6-bis(2-hydroxyethylamino)-1,4-benzoquinoneVerbasosideNocardicin A(2S,4R)-4-(beta-D-Glucopyranosyloxy)-2-pentanolTrans-p-Coumaroyl beta-D-glucopyranosideKetoprofen glucuronideFluocortolone2,6-di-tert-butyl-4-nitrophenol12,13-trans-Epoxy-9-oxo-10E,15Z-octadecadienoic acid4-Acetyl-3-Hydroxy-5-Methylphenyl Beta-D-Glucopyranoside1-IpomeanolZizybeoside ILeu-Leu[6]-Gingerdiol 5-O-beta-D-glucopyranoside3-(2-glucosyloxy-4-methoxyphenyl)propanoic acidFa(18:2+3o)Caspase-1 Inhibitor VI3-Methyl-3-butenyl apiosyl-(1->6)-glucoside13-hydroxyoctadeca-6,9,11-trienoic acid4',5,6-Trimethylscutellarein 7-glucosideLotaustralin2-O-Benzoyl-D-glucosePisumionosidePro-Tyr-GlnArg-Glu-LeuKankanoside ACaffeoyl quinic acidD-Erythroascorbic acid 1'-a-D-xylopyranosideKankanoside EGly-Gly-Ile3,5-Dihydroxyphenyl 1-O-(6-O-galloyl-beta-D-glucopyranoside)Ala-Val-LeuCytidine2-Furoylglycine(-)-Pinoresinol glucosideCaffeic acid 3-glucosideAzilsartan medoxomil4'-Hydroxyacetophenone 4'-[4-hydroxybenzoyl-(->5)-apiosyl-(1->2)-glucoside]Acetaminophen glucuronide5-(4-sulfophenyl)undecanePterosupinApogossypolone(7R,8S)-Dihydrodehydrodiconiferyl Alcohol 9-O-Beta-D-Glucopyranoside7,8-Dihydrovomifoliol 9-[apiosyl-(1->6)-glucoside]Picrosid II, HPLC GradeDjalonenolN-(4-Aminobenzoyl)-L-glutamic acidLeu-Leu-AspBeta-GlucogallinSalvimirzacolideIle-Gly-LeuHydrocotarnineClomoxirMalonyldaidzinTyr-Val-Glu-AspGlas#3Traumatic AcidHistidinohydroxylysinonorleucineTeucardosideErinapyrone CPhysalolactone B 3-glucoside3-(5-hydroxy-2,3-dimethyl-3-tricyclo[2.2.1.02,6]heptanyl)propanoic acidMycophenolic acid O-acyl-glucuronideAscr#19Testosterone glucuronideCellulaseClauslactone NBarrinic acidAscr#11Estriol 3-sulfate 16-glucuronide(2R,3R)-3,3',4',7-Tetrahydroxyflavanone 7-O-alpha-L-RhamnopyranosideBurkinabin BTuberosinEmbelin3,3',5,5'-Tetra-tert-butyl-4,4'-dihydroxybiphenyl4'-DemethylepipodophyllotoxinCantharidic acidLonfuranacid AMethyl vanillate glucoside2-isopropylmalic acidMorronisidebeta-Alanine4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-oneLuteolin 7-O-diglucuronideMiroprofenBergeninGly-LeuNalbuphineFormycin bVal-Thr-LeuAlbiflorinTrp-Ala-ThrHistidyltyrosineAsp-Val-IleEthyl glucuronideCitrininPe(18:3/0:0)D-erythro-Eritadenine3,4-DihydroaucubinDarendoside aKutkoside3a,6b,7a,12a-Tetrahydroxy-5b-cholanoic acidDodecatrienoic acidMethyl pheophorbide b3-(5-Methyl-2-furyl)prop-2-enalTentoxinN-[(1R,2S,3R,5R)-2,3-dihydroxy-5-pyridin-3-ylcyclopentyl]cyclobutanecarboxamideIndoxacarb5-Fluorodeoxyuridine monophosphateLpe(16:0)Chebuloside II5-8'-Benzofuran dehydrodiferulic acidGein12-Hydroxynevirapine glucuronide6-Oxo-7(9)-dehydro-6,7-dihydrogeranyl acetateCreoside IIIsoconiferinoside(3b,9R)-5-Megastigmene-3,9-diol 9-[apiosyl-(1->6)-glucoside]HarpagosideD-sorbitolFluocortinFisetinGlu-Ile-ValMethylglucopyranosiduronic acid13-hpotreForodesine2-keto-3-deoxy-d-gluconic acid6-(3-benzoyloxy-2-hydroxypropoxy)-3,4,5-trihydroxyoxane-2-carboxylic acid12S,13S-Epoxy-9S-hydroxy-10E,15Z-octadecadienoic acidChlorophyllide aPhenyllactic acid5-Hydroxytryptophol glucuronideAmarogentinNPCKanokoside A1-O-CaffeoylglucoseKanokoside D9-Oxohexadecanoic acidKanokoside CKanokoside BArtomunoxanthentrioneTrachelosperoside B12-Hydroxybenzaldehyde O-[xylosyl-(1->6)-glucoside]4,6,7-trihydroxy-10-methyl-3-methylidene-2-oxaspiro[4.5]decan-1-oneButyl (S)-3-hydroxybutyrate glucosideN-Methyl-14-O-demethylepiporphyroxine5-(2-Aminopropyl)benzofuranCitreoviridinItoside LAtractyloside ABeta-D-Galactosyl-(1->4)-L-rhamnoseLeu-Gln-Tyr2-hydroxy-3,4-dimethoxybenzoic acidTrans-AconitateOxaloglutarateHesperetin 7-glucoside(S)-N-MethylcoclaurineMometasone furoate(+)-NeomethynolideRamontosideBazouanthroneEnoxacinMethyl salicylate O-[rhamnosyl-(1->6)-glucoside](-)-WikstromolShanzhiside3-O-cis-Coumaroylmaslinic acidElatoside GGly-Phe7-Hydroxyterpineol 8-glucosideLactupicrin2-Phenylethanol glucuronideN2-(2-Carboxymethyl-2-hydroxysuccinoyl)arginineLeu-IleQuercilicoside APutaminoxin E4-Methoxybenzyl O-(2-sulfoglucoside)Ganoderiol ICaulersinCellobioseIle-PheNNAL-N-glucuronideVitamin A2 aldehyde(2R)-6,8-Diglucopyranosyl-4',5,7-trihydroxyflavanoneMethotrexateAcetylleucineM-ChlorophenylbiguanideCryptophycinDihydromyricetin 3-rhamnosideGeniposidic acidErythronolide ANonanoic acidDG(5-iso PGF2VI/0:0/2:0)Sebacic acidFluprednisolone(2E,11Z)-Wyerone acid19-hydroxy-2,3-dinor-6-oxo-PGF1alpha3-isopropylmalic acid4'-Azidocytidine4-Hydroxymandelic acid5-DeoxykievitonePhytolaccoside BPonesimodCellobioside4-O-Carboxymethyl ascochlorinFludrocortisone3,5-bis(methylthio)-N-[4-(1,2,3-thiadiazol-4-yl)phenyl]isothiazole-4-carboxamideGambogic acidCresopyrine2,6,10,14-Tetramethyl-6,10,15-hexadecatriene-2,3,8,14-tetrol 8-acetate9,10-dihydroxy-3,6,6-trimethyl-12-oxatetracyclo[8.3.0.01,3.04,8]tridecan-13-oneHymenoside MApigeninRubuside JPicrocrocinLanabecestatPicroside iiiPinolidoxinDodecanedioic acid1-(3-Methyl-2-butenoyl)-6-apiosylglucoseFludrocortisone acetateLappaol FUstiloxin DLappaol CRigosertib6-Heptenyl glucosinolateKaempferol 3-glucuronosideJunipediol B 8-O-glucosideCosmosporaside BCedazuridineOleosideDodecyl sulfate9,12,13-TodeaN-Salicyloylaspartic acidSildenafilExo,exo-1,8-Epoxy-p-menthane-2,6-diolOchratoxin betaIcariside F2MonotropeinTrp-Ile-AspLeu-Glu4,7-Dioxoheptanoic acidRosmarinine N-oxideSwerilactone L3-Hydroxysebacic acidIsobrucein A11-(2-methoxy-3,4-dimethyl-5-oxofuran-2-yl)undecanoic acid4-Hydroxyphenylpyruvic AcidFlavone base+3o,1meo,o-hexa-hexaPandangolide 1DaphnetinUric acid oxalate6beta-Hydroxydexamethasone1-ethyl-4-butyltetralin-6-sulfonic acid2,2'-(3-methylcyclohexane-1,1-diyl)diacetic acidDisaccharides((2methyl-hex)-pen)Murnac-tripeptideAbafunginIsoflupredone acetate(+/-)13-HpODEHypocrellin aFormononetin 7-(2-p-hydroxybenzoylglucoside)Tyr-Asn-TyrCoronaric acidN-Methyl-D-aspartic acidLinalool 3,7-oxide beta-primeverosideAbscisic alcohol 11-glucosideOscr#14Indoxyl glucuronideOscr#16HieracinTichocarpol A6-Acetoxy-7-hydroxymyrcene-7-O-beta-D-glucopyranoside-2'-O-acetate1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea4-Formyl-3-(formylmethyl)-4-hexenoic acidKhelmarin DAnemoninDecarbamoylsaxitoxinLeonoside BLoganic acidBracteatin9-Peroxy-5,6E-dehydro-6,7-dihydrogeranyl acetateMedicagenic acid beta-maltoside(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylateHenatinibfalseIntegrated transcriptomic and metabolomic analysis reveals insights into drought stress in Plantago lanceolataBackground: The unique vertical climate of Yunnan Province provides diverse resources for livestock development; however, frequent seasonal droughts during winter and spring result in a severe imbalance between forage supply and demand, constituting a major bottleneck for sustainable pastoral agriculture. Plantago lanceolata, a high-quality forage species characterized by exceptional drought and poverty tolerance, offers significant agronomic advantages, including early spring regrowth and suitability for over-sowing in perennial pastures. These traits make it vital for mitigating forage shortages and ensuring a stable supply in Yunnan. Although commercially cultivated in New Zealand and Australia, its adaptability evaluation and the molecular mechanisms underlying its drought resistance in China remain largely unexplored. Results: In this study, pot-based water-restricted experiments were conducted to simulate field drought conditions (Ψs ≈ -0.94 MPa). Systemic physiological and molecular responses were analyzed using biochemical assays, transcriptomics (Illumina NovaSeq 6000), and non-targeted metabolomics (LC-MS). Drought stress reduced the net photosynthetic rate by 93.2% while increasing peroxidase activity by 495.7%. Transcriptomic profiling identified 12,572 DEGs, which were significantly enriched in pathways related to photosynthesis, ROS scavenging, flavonoid biosynthesis, and phytohormone signal transduction. Metabolomic analysis detected 372 DEMs, with flavonoids (flavones and flavonols) and soluble sugars identified as the primary responsive metabolites. Integrated multi-omics analysis further screened key genes involved in drought tolerance regulation, including FNS II, F3H, and LOX. Conclusion: This study elucidates a multi-layered drought resistance mechanism in Plantago lanceolata, characterized by the synergistic coordination of ABA-JA hormonal crosstalk, photosystem remodeling, low-energy carbohydrate-mediated osmotic adjustment, and compartmentalized antioxidant defense, with flavonoid biosynthesis acting as a terminal chemical barrier. Key candidate genes and metabolites associated with these responses were identified. These findings provide multi-omic evidence for elucidating the environmental adaptation mechanisms of Plantago lanceolata and offer valuable candidate gene targets for the molecular breeding of stress-resistant forage 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