Metabolite identification was performed by accurate mass matching (mass tolerance < 10 ppm) and MS/MS spectral matching (mass tolerance < 0.01 Da) against public databases including HMDB, MassBank, GNPS, as well as a self-built Bioprofile (BP-DB) metabolite standard library.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - negative - reverse-phase","Liquid Chromatography MS - positive - reverse-phase"],"chromatography_protocol":["Throughout the analysis, samples were kept in the autosampler at 4°C. The separation was performed on a SHIMADZU-LC30 ultra-high performance liquid chromatography (UHPLC) system using an ACQUITY UPLC® HSS T3 column (2.1 × 100 mm, 1.8 μm) (Waters, Milford, MA, USA). The injection volume was 4 μL, the column temperature was maintained at 40°C, and the flow rate was 0.3 mL/min. The mobile phases consisted of (A) 0.1% formic acid in water and (B) 0.1% formic acid in acetonitrile. The gradient elution program was as follows: 0–2 min, 0% B; 2–6 min, B linearly increased from 0% to 48%; 6–10 min, B linearly increased from 48% to 100%; 10–12 min, B held at 100%; 12–12.1 min, B linearly decreased from 100% to 0%; 12.1–15 min, B held at 0%
"],"publication":["Adipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma by stabilizing IRF4 via NAT10-mediated acetylation."],"submitter_affiliation":["Anhui Medical University"],"submitter_name":["RUI LI"],"organism_part":["cell culture supernatant"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["Thaw the sample at 4°C. Transfer 1 mL of the sample into an EP tube and concentrate it to dryness using a high-speed vacuum centrifuge. Add 1 mL of pre-chilled methanol-water solution (4:1, v/v), then sonicate in an ice bath for 20 min. Leave the mixture to stand at -20°C for 1 h, followed by centrifugation at 16,000g and 4°C for 20 min. Collect the supernatant and evaporate it to dryness in a high-speed vacuum centrifuge. For mass spectrometry analysis, reconstitute the residue with 100 μL of pre-chilled methanol-water solution (1:1, v/v), centrifuge at 20,000g and 4°C for 15 min, and then take the supernatant for injection analysis.
"],"organism":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS14445"],"author":["Li Zongwei. Anhui Medical University. Hongyi East Building, East Campus of Anhui Medical University, Tanghe Road, Yaohai District, Hefei City, Anhui Province. lizongwei@ahmu.edu.cn.","song Chen. Anhui Medical University. East Campus, Anhui Medical University Address: Tanghe Road, Xinzhan High-tech Industrial Development Zone, Hefei City, Anhui Province, 230012, China. Songchen1022613@163.com."],"data_transformation_protocol":["Raw data were processed using MSDIAL software for peak alignment, retention time correction, and peak area extraction.
"],"study_factor":["Group"],"submitter_email":["18130577714@163.com"],"sample_collection_protocol":["For metabolomic profiling of AD-CM, conditioned media from adipocytes cultured under normal glucose or GD conditions were collected and subjected to metabolomic analysis. Metabolites were extracted and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Data processing and differential analysis identified significantly altered metabolites between the two conditions.
"],"omics_type":["Metabolomics"],"study_design":["Shimadzu Nexera X16","Metabolomics","Shimadzu Nexera X15","Shimadzu Nexera X17","untargeted analysis","Shimadzu Nexera X8","cell culture supernatant","Shimadzu Nexera X9","Homo sapiens","Shimadzu Nexera X10","Shimadzu Nexera X4","Shimadzu Nexera X12","Shimadzu Nexera X5","Shimadzu Nexera X11","pooled sample","Shimadzu Nexera X6","Shimadzu Nexera X14","untargeted metabolite profiling","Shimadzu Nexera X7","Shimadzu Nexera X13","Shimadzu Nexera X2","Shimadzu Nexera X3","Thermo Scientific Q Exactive","Multiple Myeloma"],"curator_keywords":["Shimadzu Nexera X16","Metabolomics","Shimadzu Nexera X15","Shimadzu Nexera X17","untargeted analysis","Shimadzu Nexera X8","cell culture supernatant","Shimadzu Nexera X9","Homo sapiens","Shimadzu Nexera X10","Shimadzu Nexera X4","Shimadzu Nexera X12","Shimadzu Nexera X5","Shimadzu Nexera X11","pooled sample","Shimadzu Nexera X6","Shimadzu Nexera X14","untargeted metabolite profiling","Shimadzu Nexera X7","Shimadzu Nexera X13","Shimadzu Nexera X2","Shimadzu Nexera X3","Thermo Scientific Q Exactive","Multiple Myeloma"],"mass_spectrometry_protocol":["Each sample was analyzed using electrospray ionization (ESI) in both positive (+) and negative (−) ion modes. After UPLC separation, mass spectrometry analysis was performed using a QE Plus mass spectrometer (Thermo Scientific) equipped with a HESI source. The ionization conditions were as follows: Spray Voltage: 3.8 kV (+) and 3.2 kV (−); Capillary Temperature: 320 °C; Sheath Gas: 30 arbitrary units; Aux Gas: 5 arbitrary units; Probe Heater Temperature: 350 °C; S-Lens RF Level: 50.
The MS acquisition settings were as follows:
Total MS acquisition time: 15 min. MS1 scan range: 75–1050 m/z; MS1 resolution: 70,000 @ m/z 200; AGC target: 3e6; Maximum IT (MS1): 100 ms. MS2 analysis was performed as follows: after each full scan, ten MS2 spectra were triggered for the top ten most intense precursor ions. MS2 resolution: 17,500 @ m/z 200; AGC target: 1e5; Maximum IT (MS2): 50 ms; MS2 activation type: HCD; Isolation window: 2 m/z; Normalized collision energy (stepped): 20, 30, 40.
"],"metabolite_name":["D-Leucine","N-Fructosyl isoleucine","Butyric acid","N-Acetyldopamine","PC(16:0/18:2)","Guaiacol","2-Methyl-4-oxopentanedioic acid","(7E)-3-Isobutyl-13-methoxy-4,5,8-trimethyl-3,3a,4,6a,9,10,11,12,13,14-decahydro-1H-cycloundeca[d]isoindole-1,15(2H)-dione","PE(16:0/20:4)","Pseudoanisatin","Reserpine","Folic Acid","6-Aminoindazole","N-Desmethylrosiglitazone","1,5-Naphthalenediamine","Amphetamine","2-Ethyl-1-hexanol sulfate","N-Methylisoleucine","N-{2-[4-(N,N-diethylcarbamoyl)-2-methoxyphenoxy]ethyl}acetamide","4-Hydroxybenzaldehyde","Acetamide, N-(3-amino-4-methoxyphenyl)-","Cyclopentylamine","Dehydrohistidyltryptophyldiketopiperazine","Cyclohexylamine","1,3-dimethoxy-10,10,10a-trimethyl-6,7,10a-trihydro-1,3-oxazolidino[4,3-a]phtha lazine-5,8-dione","Lauryl Diethanolamide","N-cyclopentyl-2-{4-[(6-ethoxy-2-oxochromen-4-yl)methyl]piperazinyl}acetamide","2-(4-oxoquinazolin-3(4H)-yl)ethyl isobutyrate","4-hydroxy-3-phenyl-6-(phenylmethoxy)hydroquinolin-2-one","Roquefortine E","Pilocarpine","Cyclododecalactam","10,11-Dihydroxycarbamazepine","3-methylpyrazolyl 3,4,5-trimethoxyphenyl ketone","cis-3-Hexenyl lactate","2'-O-Methylguanosine","Arginine","Gangaleoidin","Fusaric acid","(6R,8Z)-6-Hydroxy-3-oxotetradecenoic acid","3,6-Diphenylcyclohexan-1,2-diol","2,8-Dihydroxyquinoline","Obtucarbamate A","FMN","N-[1-(4-methoxy-6-oxopyran-2-yl)-2-methylbutyl]acetamide","Caffeic acid","8-Methyl-IQX","PC(16:0/18:1)","4-Amino-5-hydroxymethyl-2-methylpyrimidine","Salicylamide","Methylergonovine","Isotretinoin","Lidocaine","3-Hydroxydodecanedioic acid","2-Cyclopenten-1-one","Pantothenic acid","Eudesmin","3-Methylazelaic acid","Glutamylphenylalanine","PI(18:0/18:2)","Malonic semialdehyde","L-Ornithine","3-butyl-4-hydroxy-1-phenylhydroquinolin-2-one","batatasin III","Quinolinol","Saccharin","Diphenyl phosphate","Pipemidic acid","Metalaxyl","Phenylephrine","Vanillic acid","Monoisobutyl phthalate","Acetoacetic acid","Octaethylene glycol","Pongamol","Rhodiocyanoside A","Benzoxazine","Xanthyletin","Aminoadipic acid","3-Hydroxymyristic Acid","4-Methylphthalic anhydride","Homoarecoline","Lasiocarpine N-oxide","4-Deoxyerythronic acid","SM(d16:1/16:0)","Dimethyl 5-sulphoisophthalate","2-Isopropyl-6-methyl-4-pyrimidone","Pyridine","4-Hydroxyquinoline","Anisole","Noroxyhydrastinine","Methyl 2-Hydroxyisobutyrate","PC(18:3/18:3)","Ornithine","LPC(18:2)","3-Methyladenine","D-Glucose","Indole","Prostaglandin A1","Phenylsulfate","Furanone A","Cyclo(Pro-Leu)","Isoleucylaspartate","N-Lauroylglycine","LPC(18:1)","Fraxetin","PS(18:0/18:1)","N-(3,4-Dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide","Methylthiopropene","(S)-7-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)-2-oxoethoxy)-2-methyl-3-phenyl-4H-chromen-4-one","PIPES","(R)-2-Hydroxycaprylic acid","2-Hydroxycinnamic acid","2-oxo-1H,2H,5H,6H,7H-cyclopenta[b]pyridine-3-carbonitrile","3-Hydroxytetradecanedioic acid","Precocene II","Stearic acid amide","(S)-Actinidine","Matairesinol","Salsolinol-1-carboxylic acid","1-Hydroxy-2-butanone","LPC(18:0)","3-Hydroxybutyric acid","4-methyl-N-(((1S,9aR)-octahydro-1H-quinolizin-1-yl)methyl)-2-phenylthiazole-5-carboxamide","Ascorbic acid","2-Hydroxy-4-Methoxychalcone","3-Hydroxycapric acid","Lathyrol","5-Methylcytosine","Methylsuccinic acid","6-Methylpurine","Tetradecanedioic acid","2-[4-(N,N-diethylcarbamoyl)-2-oxohydroquinolyl]-N-(2,4-difluorophenyl)acetamid e","PC(16:0/16:0)","Isoxanthohumol","(S)-10,16-Dihydroxyhexadecanoic acid","Arginylphenylalanine","1H-Pyrrole-2-carboxaldehyde","Mono-(2-ethylhexyl)phthalate","Threonine","5,6-Dihydro-1,10-phenanthroline","N-[4-[(9S,13R)-16-hydroxy-7,9,13-trimethyl-5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-6,18-dien-6-yl]-2-methylbutyl]acetamide","N-Undecanoylglycine","L,L-Cyclo(prolylalanyl)","Norclozapine","Lysine","Acetaminophen","Alanine betaine","Bakers yeast extract","gamma-delta-Dioxovaleric acid","Trehalose","Succinic anhydride","Umbelliferone","8-Hydroxyoctanoic acid","1,3-Dimethylpyrrolo[1,2-a]pyrazine","(Z)-2-((Z)-1-(hydroxyimino)ethyl)-6,6-dimethylbicyclo[3.1.0]hexan-3-one oxime","4-Aminophenylacetic acid","1-Methylnicotinamide","N'-[(1E)-2-(3,4,5-trimethoxyphenyl)-1-azavinyl]-N-(2-methylphenyl)butane-1,4-d iamide","2-(methylethylidene)butanedioic acid","Ent-Junceic Acid","Acetanilide","cis-4-Octenedioic acid","Xanthosine","dGMP","Citraconic anhydride","Citric acid","3-Hydroxy-N-(2-oxotetrahydrofuran-3-yl)octanamide","SM(d18:0/18:1)","3-{N-[2-(4-methoxyphenyl)acetylamino]carbamoyl}propanoic acid","2-Methylpyridine","N-Acetyl-L-arginine","3-(2-Oxoazepan-1-yl)propanoic acid","3-Hydroxybenzyl alcohol","Platifillin","Eicosatetraenoic acid","Benzeneacetonitrile","1H-indole-3-carboxamide","Methylthioadenosine","Pipecolic acid","Indole-3-acrylic acid","N-(1-hydroxy-3-methylbutan-2-yl)-2-((4-oxo-3-phenyl-4H-chromen-7-yl)oxy)acetamide","Aaptamine","LPC(16:1)","Sakuranetin","PE(18:0/22:6)","Bis(2-methoxyethyl) phthalate","Warfarin","Leucyl-Isoleucine","1,3-Benzodioxole-5,6-diamine","2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-amine","Helicide","5-Hydroxymaltol","5-hydroxycalamenene","SM(d18:0/16:1)","(S)-3-Hydroxybutyric acid","Austinoneol","2-(Fluoromethyl)-3-(3,4-dihydroxyphenyl)alanine","Lumiflavin","Benzofuran","2-Propenyl cyclohexanebutanoate","Methyl acrylate","2-Hydroxyquinoxaline","LPC(16:0)","PE(18:0/22:4)","Jaranol","Vanillyl alcohol","1,2-Dihydroquinoline","3',4'-Dihydroxy-.alpha.-naphthoflavone","1,5-Anhydrosorbitol","3-methoxy-4-(2-oxo-2-piperidylethoxy)benzaldehyde","Myoinositol","2-(4-methyl-6-(2-naphthyloxy)pyrimidin-2-ylthio)-1-phenylethan-1-one","Skimmianine","Protoanemonin","6-n-Propyluracil","Triptophenolide","2,5-Dihydro-2,4,5-trimethyloxazole","6-[(Propan-2-yl)oxy]pyridine-3-carboxylic acid","O-Adipoylcarnitine","N-Acetylasparagine","ethyl 2-[2-(1,3,7-trimethyl-2,6-dioxo-1,3,7-trihydropurin-8-ylthio)benzimidazo lyl]acetate","2-Hydroxyglutaric acid","2-(4-Methylphenyl)chromen-4-one","1-Methyladenosine","1-(2-Hydroxyethyl)-2,2,6,6-tetramethyl-4-hydroxypiperidine","Acetylleucine (isomer of 164)","9,10-DiHOME","2-(1-hydroxy-1-methoxy-3-methylbutyl)-6-methyl-5H-[1,3]dioxolo[4,5-c]pyridin-4-one","PE(18:0/22:5)","Zinniol","PS(18:0/22:6)","Creatine riboside","2,5-Dihydro-1H-pyrrole-2-carboxylic acid","Tridecanoylglycine","PC(18:1/14:0)","Pirbuterol","Trifluoroacetic acid","1-Carboxyethylvaline","Tridecanedioic acid","8-Amino-7-oxononanoic acid","9,10-Epoxyoctadecanoic acid","Pyridoxal","Trigonelline","SM(d18:1/18:1(9Z))","2-(4-Methoxy-benzoylamino)-4-methyl-pentanoic acid","N-Nonanoylglycine","Butenylcarnitine","1,2,3,4,Tetrahydro-1,5,7-trimethylnapthalene","2-(4-hydroxyquinazolin-2-ylthio)-1-(2-methylpiperidyl)ethan-1-one","2-Naphthalenesulfonic acid","16-Hydroxy-10-oxohexadecanoic acid","Dibenz(a,j)acridine","Tetrahydropalmatine","2-Phenylethyl beta-D-glucopyranoside","gamma-Guanidinobutyric acid","(E)-5-(3,4,5,6-Tetrahydro-3-pyridylidenemethyl)-2-furanmethanol","4-Ethylaniline","N-Hydroxy-1-aminonaphthalene","Glycocyamine","N-(4-butylphenyl)(3,4,5-trimethoxyphenyl)carboxamide","Phenylalanine","Ranitidine S-oxide","PC(16:0/22:6)","Cholesterol","Gentiatibetine","methyl 2-(8-methyl-3a,4,5,6-tetrahydro-1H-pyrazino[3,2,1-jk]carbazol-3(2H)-yl)acetate","Morpholine","Tenuazonic acid","L-alpha-Amino-1H-pyrrole-1-hexanoic acid","[3H]Rosiglitazone","methyl 2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)propanoate","2-Hydroxyhexadecanoic acid","3-Hydroxy-2H-pyran-2-one","Uracil","Epijasminoside A","PE(18:0/20:4)","Difloxacin","alpha-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol","methyl 2-[(5,6,7-trimethoxy-3-oxohydroisobenzofuran-4-yl)methylthio]benzoate","Apitolisib","4-Oxo-L-proline","Creatine","N-(2-Hydroxyethyl)nicotinamide","Octopine","Isoplumbagin","4-Hydroxymandelonitrile","Simazine","Euparin","Phenylglycine","Benzothiazolone","Indole-3-acetyl-glutamic acid","Kobusone","1,3,5-Hexatriene","PS(18:0/22:4)","4-Amino-2-hydroxy-5-[[1-hydroxy-1-(2-oxo-1-bicyclo[4.1.0]hept-3-enyl)propan-2-yl]amino]-5-oxopentanoic acid","Thermopsine","Methyl 2-[(2-hydroxy-3-methylbutanoyl)amino]-3-methylbutanoate","N-lactoyl-Tyrosine","3,6,9,12,15,18,21,24,27-Nonaoxanonacosane-1,29-diol","Homovanillic acid","Triptolide","2-Phenylpyridine","3-Hydroxyoctadecanoic Acid","2-Hydroxy-4-imino-2,5-cyclohexadienone","O-Desmethyl tramadol","Indole-3-Lactic Acid","Acedoben","Isoleucine","Pantoyl lactone glucoside","Xanthone","3-Hydroxy-5Z-octenyl acetate","PE(18:0/20:3)","2,3-Diaminotoluene","2-Methylhippuric acid","Canrenone","PS(18:0/22:5)","2-[4-(sulfooxy)phenyl]acetic acid","1,2,4-Triazin-5(2H)-one, 6-(1,1-dimethylethyl)-3-(methylthio)-","Vestitol","Niflumic acid","2-Hydroxy-3-(2-hydroxyphenyl)propanoic acid","HEPES","Doxycycline","Pantothenic acid (Not validated)","PC(18:0/20:4)","Norepinephrine","Arabinosylhypoxanthine","Glutamine","PS(18:0/20:4)","Phenylacetic acid","4-[4-(2-Chlorophenyl)piperazin-1-yl]-4-oxobutanoic acid","Myristoylglycine","4,5-Dihydrovomifoliol","Tyrosylisoleucine","(1S,2R,4aR,8aR)-1-Acetoxy-7-isopropylidene-1,4a-dimethyl-6-oxodecahydro-2-naphthalenyl 2,3-dimethyl-2-oxiranecarboxylate","Histidine","methyl 7-(4-chlorophenyl)-4-(4-hydroxy-3-methoxyphenyl)-2-methyl-5-oxo-1,4,6,7 ,8-pentahydroquinoline-3-carboxylate","3-Hydroxycarbofuran","3,4-dimethoxyphenyl 4-(3-chlorophenyl)piperazinyl ketone","Graveolide","4-Hydroxy-3-benzylcoumarin","4-Hydroxy-2H-pyran-3-carboxaldehyde","Phosphoric acid","Berberine","N-Benzyl-4-((3-Oxo-3-(2-Oxo-2H-Chromen-3-Yl)Propyl)Amino)Benzamide","Erysubin F","Myristamine Oxide","Cadabicilone","2H-benzo[3,4-d]1,3-dioxolen-5-yl-N-(4,5,6,7-tetrahydrobenzothiazol-2-yl)carbox amide","Nalidixic acid","Indole-3-carboxyaldehyde","FA 9:0 + 1O, sulfate","Glycerophosphocholine","1(2H)-Naphthalenone, 3,4-dihydro-2-((4-methoxyphenyl)methylene)-, (E)-","[4-(difluoromethoxy)-3-ethoxyphenyl]-N-(1-methylpyrazol-3-yl)carboxamide","1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid","2-Ethylaniline","1-acetyl-3-{[2-(ethylpropyl)quinazolin-4-yl]amino}benzene","1-Dodecyl-2-pyrrolidinone","PC(16:0/20:5)","N-(3,4-dimethoxyphenethyl)-1H-indole-3-carboxamide","PC(O-16:0/18:1)","Hydroxymethyl indol-3-yl ketone","12-Hydroxy-6-Epi-Albrassitriol","3-(2-(2H,3H-benzo[3,4-e]1,4-dioxin-6-yl)-2-oxoethyl)-3-hydroquinazolin-4-one","N-Acetylputrescine","Tryptophan","Magnolol","Xanthine","DL-Cycloserine","3h-Indole-3-propanoic acid,a-amino-","2-[[(2R)-2-dodeca-4,7,10-trienoyloxy-3-hexadecoxypropoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium","Choline","Homoproline","Oxypeucedanin Hydrate","2,3,6-Trichloro-5-cyano-4-hydroxybenzamide","4-Hydroxy-N-methylcarbostyril","2-Chloro-1-methylpyridinium iodide","2,6-Di-tert-butyl-4-nitrophenol","Nicotinic acid","PG(16:0/18:1)","2-Isopropyl-5-methylpyrazine","Vitispirane","2-hydroxyacrylic Acid","DOPA","N,N-Dimethyl-N'-Phenylsulfamide","(Z)-13-Oxo-9-octadecenoic acid","2-Aminopurine","Cyclo(L-Isoleucyl-L-Isoleucyl)","Undecanedioic acid","Corydaline","S-Adenosylhomocysteine","Dimethyl sulfoxide","Acridine","2-(3,4-dimethoxyphenyl)-6,8-dimethylchromen-4-one","4-hydroxy-4-(pyridin-2-yl)butan-2-one","Phthalic anhydride","Leucine","N-(3-bromophenyl)-2-[4-(morpholin-4-ylcarbonyl)-2-oxohydroquinolyl]acetamide","(R)-alpha-Methylhistamine","Citramalic acid","Bis(3-Allyl-4-Hydroxyphenyl)Sulfone","(7,8-dimethoxy-2,2,3-trimethyl-2,3-dihydro-1H-benzo[d]azepin-4-yl)(3,4-dimethoxyphenyl)methanone","p-Aminobenzoic acid","5-Pentyl-2-furanheptanoic acid","2-Hydroxymyristic acid","PS(18:0/20:3)","3,5-Dihydroxy-4-[3,4,5-trihydroxy-6-[[4-(2-hydroxypropan-2-yl)cyclohexene-1-carbonyl]oxymethyl]oxan-2-yl]oxybenzoic acid","PE(P-18:0/20:4)","Isobavachin","p-Coumaric acid","2-Acetyl-1,5,6,7-tetrahydro-6-hydroxy-7-(hydroxymethyl)-4H-azepine-4-one","FA 9:2+1O","2-Pentanamido-3-phenylpropanoic acid","Phosphocholine","4H-1-Benzopyran-4-one, 6-methyl-2-(2-methylphenyl)-","o-Dodecylbenzenesulfonic acid","PharmaGSID_47333","7-Amino-4-methylcoumarin","2-Cyanoacetamide","NA-135","Isoeugenyl acetate","(2Z)-2-benzoxazol-2-yl-3-(4-hydroxy-3-methoxyphenyl)-1-(4-methylphenyl)prop-2- en-1-one","alpha-Irone","LPC(20:4)","(10betaH,11xi)-11-Hydroxy-13-nor-6-eremophilen-8-one","PG(18:0/18:1)","N-Isovaleroylglycine","Riboflavin","Lauramidopropylbetaine","Folic acid","Mebendazole","7-[(2-fluorophenyl)methoxy]-4-methylchromen-2-one","6,10a-Dihydroxy-4-(hydroxymethyl)-4,7,11b-trimethyl-1,2,3,4a,5,6,6a,7,11,11a-decahydronaphtho[2,1-][1]benzouran-9-one","Succinoadenosine","Quinoline","Alibendol","m-Aminobenzoic acid","PE(18:1/20:4)","Vasicinone","Lauryl Ether Sulphate","Octadecenedioic acid","ethyl 10-[2-(3,4-dimethoxyphenyl)ethyl]-2,4-dioxo-3,10-dihydrobenzo[g]pteridin e-8-carboxylate","Biotin","GMP","4-[Formyl(6-Methoxyquinolin-8-Yl)Amino]Pentanoic Acid","4-[(4-chlorophenyl)methyl]-7-hydroxy-3-phenylchromen-2-one","Neotrehalose","Phenol","2-Furanmethanol","Neomycin","PI(18:0/20:3)","2-Propenoic acid, 2-(hydroxymethyl)-, (1aR,5aR,8aR,9S,10aR,11R)-1a,2,5a,7,8,8a,9,10-octahydro-11-hydroxy-8-methylene-7-oxo-3H-4,10a-(methanooxymethano)oxireno[5,6]cyclodeca[1,2-b]furan-9-yl ester","Thiazole","Leucinic acid","Myclobutanil","Calystegine A6","Dicyclohexylamine","1,7-Diphenyl-5-hydroxy-1-heptene-3-one","Cinnamic acid","PC(18:1/18:2)","Triethylene glycol monomethyl ether","3,4-dimethyl-9-phenyl-7H-furo[2,3-f]chromen-7-one","4-(2-Furanylmethylene)-3,4-dihydro-2H-pyrrole","2,2,6,6-Tetramethyl-4-piperidinol","LPE(18:0)","3-(2-chlorophenyl)-7-hydroxychromen-2-one","Glutaric acid","9,10,13-TriHOME","PI(18:0/20:4)","Magnocurarine","Risedronate Sodium","2-Methoxy-3,4-dimethylphenyl acetate","1-Piperidinecarboxaldehyde","Lignocaine N-oxide","(2E)-3-(1H-Indol-2-Yl)Prop-2-Enoic Acid","N,N-Diethyl-4-Hydroxybenzamide","3',5'-Dideoxythymidine","3'-GMP","3-(2-Furanyl)-2-propenal","2-(3-(8-hydroxyoctyl)phenoxy)-2-methylpropanoic acid","5-[5-Hydroxy-3-(hydroxymethyl)pentyl]-8a-(hydroxymethyl)-5,6-dimethyl-3,4,4a,6,7,8-hexahydronaphthalene-1-carboxylic acid","PC(17:0/16:1)-D5","N-(2,4-dioxo(1,3-dihydropyrimidin-5-yl))-2-phenoxypropanamide","Cyanazine","PC(16:0/P-16:0)","PE(18:1/20:1)","2-(4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-pyrazol-5-yl)-4-ethyl-5-methoxyphenol","Hemineurine","gamma-Glutamylisoleucine","Pratol","Ketoprofen","1,3,6-Trihydroxy-2-(3-methylbut-2-enyl)xanthen-9-one","Pseudouridine 5'-phosphate","8-Acetamido-2-methyl-7-oxononanoic acid","5-Butyl-2-methylpyridine","PA(16:0/18:1)","Triacanthine","1-Aminocyclopentane-1,3-Dicarboxylic Acid","Piconol","Melilotic acid","3-Buten-2-one, 4-[4-(beta-D-glucopyranosyloxy)-2-hydroxy-2,6,6-trimethylcyclohexylidene]-","Memantine","Sulfamethazine","4-methylquinoline-2-carboxylic acid","(S)-3-(4-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)-2-oxoethoxy)phenyl)-8-methoxy-2H-chromen-2-one","Cyproconazole","Imazamox","1,2,3,4-Tetrahydroquinoxaline","1-Carboxyethylphenylalanine","Viridicatol","5-Dihydroxyhept-6-enoic acid","Isophthalic acid","Proline","Deferiprone","Anisic acid","Huperzine A","LPC(22:4)","Tetrahydropyridine","3-Hydroxymethylglutaric acid","Citromycetin","epsilon-Maleimido-lysine","Isoindoline","Cerulenin","1-Palmitoyl-2-thiopalmitoyl phosphatidylcholine","Thiamine","Capric dimethyl amine oxide","Indole-3-acetic acid","Norhygrine","Suberylglycine","Tetradecyldiethanolamine","10,11-dihydro-20-dihydroxy-LTB4","LPC(22:5)","Butyl 4-aminobenzoate","(Z)-5-[(2R,3S,4S)-4-Hydroxy-2-[(E)-3-hydroxyoct-1-enyl]oxan-3-yl]pent-3-enoic acid","Fumaric acid","6b-Hydroxy-8a-methoxy-7(11)-eremophilen-12,8-olide","1-(3-carboxypropyl)-3,7-dimethylxanthine","Myrsinone","N-Lactoylvaline","Kaurenic acid","Docosa-2,4,6,8-tetraenoic acid","Hydroxysuberic acid","PC(16:0/P-18:1)","Auraptene","Clorophene","Microminutin","Acoric acid","ethyl 4-hydroxy-3-methyl-2-oxohydroquinoline-6-carboxylate","Murracarpin","phenylmethyl 1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]pyrrolidine-2-carboxylate","Trachelanthine","LPE(16:0)","LPC(22:6)","Atractylenolide II","Pyrroline hydroxycarboxylate","PI(18:0/22:4)","6-methoxyflindersine","Spermidine","Indole-5,6-quinone","Methoxyacetic acid","Sissotrine","3-hydroxy-N-(2-oxooxolan-3-yl)tetradecanamide","2-Methyl-2-phenylsuccinimide","2-Isopropylmalic acid","Linderalactone","N,N'-Diphenylguanidine","PC(20:5/16:0)","1-Methyl-1,2-dihydropyridine-3-carboxamide","PE(22:6/18:0)","2H-benzo[d]1,3-dioxolan-5-yl-N-(4,5-dimethyl(1,3-thiazol-2-yl))carboxamide","Flavokawain A","Acetone cyanohydrin","3-Phenylacetylamino-2,6-piperidinedione","Glutamic acid","5-butyl-3-methyl-7H-furo[3,2-g]chromen-7-one","Psicose","20-Hydroxy-PGF2a","4-Formylaminoantipyrine","Suberic acid","Hydroxyproline","1H-Imidazole-4-carboxamide","Zearalenone","4-Nitrophenol","6-Ethylthiopurine","Piperine","3-Phenyl-3-(pyridin-2-yl)propanoic acid","PE(16:0/18:1)","2,3,4,9-Tetrahydro-6-methoxy-1H-pyrido(3,4-b)indol-1-one","Ritalinic acid","Masoprocol","PC(18:1/16:0)","2-Hydroxypyridine","Quetiapine","(3R,3aR,7aS)-3-Butylhexahydro-1(3H)-isobenzofuranone","Creatinine","Tyrosylproline","Transcrocetinate sodium","4-Vinylcyclohexene","2H-Benzotriazole","Pyridoxine","1-O-Hexadecyl-sn-glycero-3-phosphocholine","PE(P-16:0/20:4)","Carbazole","5-Hydroxyhexadecanoic acid","Di-N-propylamine","3-Methylquercetin","beta-carboline","Dihydrobiopterin","3-Methylene-indolenine","Theobromine","S-(2-Carboxypropyl)glutathione","Pregabalin","5-[(1-Iminoethyl)amino]-2-aminopentanoic acid","2-oxo-Butanal","1-Hydroxy-2,2,6,6-tetramethyl-4-piperidinone","4-Octylphenol","Dihydroartemisinin (DHA)","Betaine","5-Oxooctadecanoic acid","Neoline","4-Quinolinecarboxylate","1-Aminocyclopropane-1-carboxylic acid","AMP","N-Lauroyl Alanine","3-Phenyllactic acid","PC(18:0/18:2)","7-(1,6-dihydroxy-3-methyl-5-(methylethyl)-8-{[(2-methylphenyl)amino]methylene} -7-oxo(2-naphthyl))-3,8-dihydroxy-6-methyl-4-(methylethyl)-1-{[(2-methylphenyl )amino]methylene}naphthalen-2-one","PE(16:0/18:2)","Homostachydrine","5,6-Dihydroxy-2-methylaminotetralin","O-Succinylhomoserine","PC(17:0/14:1)-d5","2-Methyl-5-nitrobenzenesulfonic acid","3-Hydroxyisovaleric acid","PG(20:4/18:0)","6-hydroxyoct-1-enoylglycine","Isoprenyl alcohol","Hydrocotarnine","Schembl12549091","6-bromo-2-(2-methylphenyl)chromen-4-one","1-Pyrrolidinecarboxaldehyde","Amitriptyline","Triphenylphosphine oxide","Hyodeoxycholic acid","1H-Indene-1,2(3H)-dione","2-Aminoanthraquinone","Imidazooxazole","2-Hydroxybenzonitrile","3-Ethylpyridine","SM(d18:2/16:0)","Dictyoquinazol A","Dictyoquinazol C","Rutecarpine","3-hydroxy-3-(3-hydroxyphenyl)propanoic acid-O-sulphate","2-Methylthioadenosine","methyl 2-{2-methoxy-4-[(3,4,5-trimethoxyphenyl)carbonylamino]phenoxy}acetate","5-Hydroxytryptophan","Kynurenic acid","N-Formylmethionine","Harmol Hydrochloride","Methionine","Cepharanthine","4-Anilino-4-oxobutanoic acid","N-(3,4-dimethylphenyl)(2-iminochromen-3-yl)carboxamide","3-Ethylfuran","2-(4-oxo-1,2,3,5-tetrahydrocyclopenta[1,2-c]quinolin-5-yl)acetic acid","Styrene","Bromacil","2,4-Dihydroxypyridine","Gallic acid methyl ester","Nonaethylene glycol","Citrinin","Benzyladenine","Lauryldiethanolamine","2,5-Piperazinedione","Cupressic acid","Mmv688469","Sotalol","PC(18:2/18:2)","p-Coumaraldehyde","4-hydroxy-1-phenyl-3-benzylhydroquinolin-2-one","4-Acetoxy-2-hexyltetrahydrofuran","Kaempferol","Kojic acid","2-{4-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-enyl]phenoxy}acetamide","Phenylacetylglycine","(4E)-7-Acetoxy-6-hydroxy-2-methyl-10-oxo-3,6,7,8,9,10-hexahydro-2H-oxecin-3-yl (2E)-2-butenoate","Osthole","2-Imino-N-(4-Methylphenyl)-2H-Chromene-3-Carboxamide","PE(18:1/16:0)","PC(O-16:0/20:5)","PC(20:4/20:4)","1-Piperideine-2-carboxylic acid","Tschimganidin","(6-chloro-2-iminochromen-3-yl)-N-(4-ethylphenyl)carboxamide","O-Arachidonoylglycidol","PC(16:1/16:1)","Phytosphingosine","2,4-Dichlorophenol","N-(2-chlorophenyl)-2-[2-oxo-4-(piperidylcarbonyl)hydroquinolyl]acetamide","Oryzalin","Gelomulide N","Valerenic acid","Tyrosine","PS(18:1/18:0)","9,10-Dihydroxystearic acid","3-Ureidopropionic acid","5-Methylpyrazine-2-carboxylic Acid","Lauramine oxide","4-Methylimidazole","(6,6-Dimethylbicyclo[3.1.1]hept-2-yl)methyl 6-O-[(2R,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-beta-D-glucopyranoside","Arabitol","Maoecrystal A","Succinic acid","Hypoxanthine","PS(18:1/18:1)","3-Hydroxymonoethylglycinexylidide","N-(3-Oxododecanoyl)-L-homoserine lactone","PE(16:1/20:4)","Homoserine","Melilotin","4,7,8-Trimethoxy-3,5-dimethylchromen-2-one","Hippuric acid","Benzothiazole","(2-Amino-4-Methyl-6-Oxo-1,6-Dihydropyrimidin-5-Yl)Acetic Acid","4-Deoxypyridoxine","2-Methylbenzaldehyde","7-Ethyl-2,3,6,7-tetrahydrocyclopent[b]azepin-8(1H)-one","Taxifolin 7-rhamnoside","Cycluron","Gallacetophenone","1-Carboxyethylleucine","N-Butyrylhomoserine lactone","Oxysophocarpine","5-Hexyl-3-methyl-2-furannonanoic acid","4-(Dimethylamino)benzoic acid","Cocaine","Didanosine","Lumichrome","PE(18:1/18:1)","Carbapenem","3-Hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one","m-Toluamide","Vitamin B12","N-Acetylmethionine","Melibiose","2,6-Diamino-9-(2-hydroxyethoxymethyl)purine","Acetylleucine","Caffeine","4-Hydroxybenzoylcholine","Quinaldine","N-Acetylproline","2-Methylglutarate","3-Hydroxybenzoate","2,5-Dihydropyrimidine","8-Methylquinoline","2H-1-Benzopyran-2-one, 7-(ethylamino)-4-methyl-","PC(14:0/14:0)","N-Lactoylleucine","Cyclo(Pro-Val)","alpha-Methylene butyrolactone","2-Hydroxyvaleric acid","3,4-Dihydroxybenzylamine","Levosulpiride","3-Butylphthalic acid","PE(18:0/18:2)","Protopanaxatriol","Sulisobenzone","Pyroglutamic acid","Astragalin","Chavicol","PE(18:1/18:2)","Higenamine","Succinylcarnitine","PE(16:0/22:5)","Dodecanedioic acid","(3E,5Z)-1,3,5-Heptatriene","4-Hydroxybenzotriazole","8alpha-8-Hydroxy-12-oxo-13-abieten-18-oic acid","Fluometuron","6-Amino-1,2-benzopyrone","3-Hydroxyhexadecanoic acid","Dimethyl myristamine","Dodecyl sulfate","4-methyl-2-oxochromen-7-yl 3-chlorobenzoate","Acetylcholine","PG(16:0/20:2)","N-Decanoylglycine","Tanshinone IIA","Valerylcarnitine","Isoleucylphenylalanine","5-(6-methyl-7-oxooctyl)furan-2(5H)-one","3-Methylpimelic acid","N-Lauroylsarcosine","1-Ethyl-1H-pyrrole-2-carboxaldehyde","Flunixin","2-Methyl-4(3H)-quinazolinone","Terbutaline","2-Methyl-3-oxopropanoic acid","PC(O-18:1/20:4)","Methylmalonic acid","Malic acid","Cotinine","PC(14:0/16:0)","N-[1-(2-Methylbenzyl)-1H-Pyrazol-4-Yl]-3,4-Dihydroisoquinoline-2(1H)-Carbothioamide","3-ethyl-4-hydroxy-1-benzylhydroquinolin-2-one","4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentan-2-yl (E)-3-(4-hydroxyphenyl)prop-2-enoate","Anhydroecgonine","Vitamin K1","m-Coumaric acid","Erucamide","Erythronolactone","FA 18:4;O","6,7-Dimethoxyquinazoline-2,4(1H,3H)-dione","Docusate hydrogen","Histamine","N-Acetyltyrosine","ethyl 3-{N-[4-(ethoxycarbonyl)phenyl]carbamoyl}propanoate","Traumatin","3-Aminopicolinaldehyde","6-Dimethylaminopurine","2-Benzimidazolecarbamic acid","3,5-Dihydroxyphenylglycine","PC(14:0/16:1)","LPC(20:2)","1,3-Dicyclohexylurea","Hexadecanamide","alpha-Naphthoflavone","3-Oxotetradecanoic acid","Azelaic acid","p-Toluenesulfonamide","Prostaglandin F2b","Sebuthylazine","7-Benzofurancarboxylic acid, 2,3-dihydro-2-(1-hydroxy-1-methylethyl)-4-methoxy-6-(2-phenylethyl)-","(R)-3-Hydroxydodecanoic acid","2-Methyl-1,4-benzoquinone","6-Methyl-2-pyridinecarboxylic acid","3'-AMP","5-Hydroxyindoleacetate","Clozapine","Imazethapyr","Norvaline","3-Oxohexadecanoic acid"],"additional_accession":[]},"is_claimable":false,"name":"Adipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma by stabilizing IRF4 via NAT10-mediated acetylation","description":"Multiple myeloma (MM) remains an incurable hematologic malignancy despite advances in treatment. While obesity is a well-established risk factor, the underlying metabolic mechanisms by which adipocytes contribute to disease progression remain elusive. Here, we uncover a critical metabolic crosstalk between adipocytes and MM cells that promotes MM cell survival under glucose deprivation. We show that glucose restriction activates AMPK, leading to subcellular relocalization of HSP90 and disruption of its protective interaction with the oncoprotein IRF4, thereby rendering IRF4 susceptible to TRIM21-mediated ubiquitination and proteasomal degradation. Paradoxically, the same metabolic stress stimulates adipocytes to upregulate ketogenesis and produce β-hydroxybutyrate (β-OHB). MM cells utilize β-OHB via OXCT1-mediated ketolysis, fueling NAT10-dependent acetylation of IRF4 at K87. This acetylation event restores IRF4-HSP90 binding, thereby shielding IRF4 from degradation and sustaining tumor cell survival. Genetic ablation of Hmgcs2, the rate-limiting ketogenic enzyme, in adipocytes abrogates this protective effect. Importantly, combining an AMPK activator (metformin) with either an OXCT1 inhibitor (pimozide) or a NAT10 inhibitor (remodelin) results in potent synergistic antitumor activity in vivo. Our study thus positions β-OHB as a critical metabolic adaptor that empowers myeloma cells to circumvent glucose metabolic stress and highlights a promising combination therapeutic strategy that exploits the vulnerability arising from competing metabolic dependencies.
","dates":{"publication":"2026-05-07","submission":"2026-05-07"},"accession":"MTBLS14445","cross_references":{"HMDB":["HMDB0000517","HMDB0000244","HMDB0246248","HMDB0245820","HMDB0000292","HMDB0253648","HMDB0002151","HMDB0062177","HMDB0000699","HMDB0302261","HMDB0246269","HMDB0013267","HMDB0245928","HMDB0247450","HMDB0000157","HMDB0248513","HMDB0246328","HMDB0034054","HMDB0000671","HMDB0000239","HMDB0244121","HMDB0032985","HMDB0029734","HMDB0010384","HMDB0000158","HMDB0001488","HMDB0059696","HMDB0250671","HMDB0246419","HMDB0041287","HMDB0000086","HMDB0244166","HMDB0031713","HMDB0249611","HMDB0001271","HMDB0061889","HMDB0035878","HMDB0008138","HMDB0000048","HMDB0243890","HMDB0061888","HMDB0246358","HMDB0303912","HMDB0004710","HMDB0037559","HMDB0244733","HMDB0000097","HMDB0246466","HMDB0033624","HMDB0254199","HMDB0007972","HMDB0003409","HMDB0247095","HMDB0010382","HMDB0002815","HMDB0000564","HMDB0011473","HMDB0240587","HMDB0000715","HMDB0245309","HMDB0000177","HMDB0001847","HMDB0013317","HMDB0034146","HMDB0008048","HMDB0245025","HMDB0246827","HMDB0008097","HMDB0000210","HMDB0003033","HMDB0010404","HMDB0257047","HMDB0000159","HMDB0008100","HMDB0244345","HMDB0244077","HMDB0000121","HMDB0034587","HMDB0031256","HMDB0001520","HMDB0030346","HMDB0002177","HMDB0028932","HMDB0243760","HMDB0000209","HMDB0010383","HMDB0008039","HMDB0037605","HMDB0000030","HMDB0011718","HMDB0112184","HMDB0244157","HMDB0012101","HMDB0000162","HMDB0000875","HMDB0245733","HMDB0040646","HMDB0042004","HMDB0003040","HMDB0000738","HMDB0032918","HMDB0059712","HMDB0030016","HMDB0033373","HMDB0031057","HMDB0007973","HMDB0000784","HMDB0002327","HMDB0304442","HMDB0029796","HMDB0037326","HMDB0008002","HMDB0062363","HMDB0003464","HMDB0001891","HMDB0032923","HMDB0060980","HMDB0247230","HMDB0008206","HMDB0059754","HMDB0031031","HMDB0254201","HMDB0001392","HMDB0033731","HMDB0012153","HMDB0007866","HMDB0246650","HMDB0061088","HMDB0007869","HMDB0009012","HMDB0000872","HMDB0062176","HMDB0013286","HMDB0000734","HMDB0246859","HMDB0244507","HMDB0249324","HMDB0001172","HMDB0247665","HMDB0012273","HMDB0001046","HMDB0012897","HMDB0245117","HMDB0009004","HMDB0009684","HMDB0249034","HMDB0244123","HMDB0256501","HMDB0034171","HMDB0013716","HMDB0000122","HMDB0000623","HMDB0242026","HMDB0251563","HMDB0010731","HMDB0034074","HMDB0001545","HMDB0250799","HMDB0000733","HMDB0001369","HMDB0030908","HMDB0031581","HMDB0000402","HMDB0247327","HMDB0015129","HMDB0004620","HMDB0013250","HMDB0028716","HMDB0034276","HMDB0032929","HMDB0000067","HMDB0031702","HMDB0009036","HMDB0010402","HMDB0245238","HMDB0010396","HMDB0010574","HMDB0000912","HMDB0302281","HMDB0302903","HMDB0012502","HMDB0010167","HMDB0010733","HMDB0001232","HMDB0255446","HMDB0028914","HMDB0060015","HMDB0000299","HMDB0014426","HMDB0062503","HMDB0250302","HMDB0040442","HMDB0037398","HMDB0013742","HMDB0244873","HMDB0008937","HMDB0001429","HMDB0014399","HMDB0013272","HMDB0244880","HMDB0010392","HMDB0000696","HMDB0062181","HMDB0000043","HMDB0247291","HMDB0245035","HMDB0061650","HMDB0009022","HMDB0029636","HMDB0038165","HMDB0013751","HMDB0010737","HMDB0008927","HMDB0038291","HMDB0000167","HMDB0013464","HMDB0000064","HMDB0006219","HMDB0000442","HMDB0240311","HMDB0000254","HMDB0037798","HMDB0001044","HMDB0061658","HMDB0246557","HMDB0011600","HMDB0009011","HMDB0255912","HMDB0094766","HMDB0034903","HMDB0246758","HMDB0001859","HMDB0035291","HMDB0302525","HMDB0252340","HMDB0011352","HMDB0240616","HMDB0013773","HMDB0249030","HMDB0000719","HMDB0010165","HMDB0029880","HMDB0041929","HMDB0029819","HMDB0001101","HMDB0036057","HMDB0007991","HMDB0000228","HMDB0033895","HMDB0040588","HMDB0015573","HMDB0245199","HMDB0037151","HMDB0000926","HMDB0116607","HMDB0031404","HMDB0035631","HMDB0040551","HMDB0062295","HMDB0000202","HMDB0240626","HMDB0000606","HMDB0240638","HMDB0240493","HMDB0030636","HMDB0001084","HMDB0000665","HMDB0000172","HMDB0036058","HMDB0041943","HMDB0001713","HMDB0002261","HMDB0000779","HMDB0000714","HMDB0009815","HMDB0006088","HMDB0240627","HMDB0004610","HMDB0010730","HMDB0001398","HMDB0031199","HMDB0031507","HMDB0240687","HMDB0006779","HMDB0007994","HMDB0007996","HMDB0038628","HMDB0011664","HMDB0245295","HMDB0040435","HMDB0246998","HMDB0246511","HMDB0245084","HMDB0249614","HMDB0249473","HMDB0010166","HMDB0010604","HMDB0245386","HMDB0002203","HMDB0000725","HMDB0032358","HMDB0011129","HMDB0011111","HMDB0032173","HMDB0248994","HMDB0014507","HMDB0245168","HMDB0001173","HMDB0029559","HMDB0060997","HMDB0253423","HMDB0007870","HMDB0250793","HMDB0034107","HMDB0040009","HMDB0094680","HMDB0000754","HMDB0028903","HMDB0012088","HMDB0008994","HMDB0246592","HMDB0009813","HMDB0244231","HMDB0029737","HMDB0005779","HMDB0032930","HMDB0245497","HMDB0060678","HMDB0094646","HMDB0258715","HMDB0006028","HMDB0252556","HMDB0008443","HMDB0008495","HMDB0259922","HMDB0259770","HMDB0031345","HMDB0112104","HMDB0015522","HMDB0029864","HMDB0038321","HMDB0010163","HMDB0000641","HMDB0059757","HMDB0060427","HMDB0009060","HMDB0001935","HMDB0029865","HMDB01123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