MetaboLights

application/xml

ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14445/m_MTBLS14445_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14445/m_MTBLS14445_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14445/a_MTBLS14445_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14445/a_MTBLS14445_LC-MS_positive_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14445/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14445/s_MTBLS14445.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14445Metabolite identification was performed by accurate mass matching (mass tolerance < 10 ppm) and MS/MS spectral matching (mass tolerance < 0.01 Da) against public databases including HMDB, MassBank, GNPS, as well as a self-built Bioprofile (BP-DB) metabolite standard library.MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phaseThroughout the analysis, samples were kept in the autosampler at 4°C. The separation was performed on a SHIMADZU-LC30 ultra-high performance liquid chromatography (UHPLC) system using an ACQUITY UPLC® HSS T3 column (2.1 × 100 mm, 1.8 μm) (Waters, Milford, MA, USA). The injection volume was 4 μL, the column temperature was maintained at 40°C, and the flow rate was 0.3 mL/min. The mobile phases consisted of (A) 0.1% formic acid in water and (B) 0.1% formic acid in acetonitrile. The gradient elution program was as follows: 0–2 min, 0% B; 2–6 min, B linearly increased from 0% to 48%; 6–10 min, B linearly increased from 48% to 100%; 10–12 min, B held at 100%; 12–12.1 min, B linearly decreased from 100% to 0%; 12.1–15 min, B held at 0%Adipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma by stabilizing IRF4 via NAT10-mediated acetylation.Anhui Medical UniversityRUI LIcell culture supernatantmass spectrometry assayThaw the sample at 4°C. Transfer 1 mL of the sample into an EP tube and concentrate it to dryness using a high-speed vacuum centrifuge. Add 1 mL of pre-chilled methanol-water solution (4:1, v/v), then sonicate in an ice bath for 20 min. Leave the mixture to stand at -20°C for 1 h, followed by centrifugation at 16,000g and 4°C for 20 min. Collect the supernatant and evaporate it to dryness in a high-speed vacuum centrifuge. For mass spectrometry analysis, reconstitute the residue with 100 μL of pre-chilled methanol-water solution (1:1, v/v), centrifuge at 20,000g and 4°C for 15 min, and then take the supernatant for injection analysis.Homo sapienshttps://www.ebi.ac.uk/metabolights/MTBLS14445Li Zongwei. Anhui Medical University. Hongyi East Building, East Campus of Anhui Medical University, Tanghe Road, Yaohai District, Hefei City, Anhui Province. lizongwei@ahmu.edu.cn.song Chen. Anhui Medical University. East Campus, Anhui Medical University Address: Tanghe Road, Xinzhan High-tech Industrial Development Zone, Hefei City, Anhui Province, 230012, China. Songchen1022613@163.com.Raw data were processed using MSDIAL software for peak alignment, retention time correction, and peak area extraction.Group18130577714@163.com For metabolomic profiling of AD-CM, conditioned media from adipocytes cultured under normal glucose or GD conditions were collected and subjected to metabolomic analysis. Metabolites were extracted and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Data processing and differential analysis identified significantly altered metabolites between the two conditions.MetabolomicsShimadzu Nexera X16MetabolomicsShimadzu Nexera X15Shimadzu Nexera X17untargeted analysisShimadzu Nexera X8cell culture supernatantShimadzu Nexera X9Homo sapiensShimadzu Nexera X10Shimadzu Nexera X4Shimadzu Nexera X12Shimadzu Nexera X5Shimadzu Nexera X11pooled sampleShimadzu Nexera X6Shimadzu Nexera X14untargeted metabolite profilingShimadzu Nexera X7Shimadzu Nexera X13Shimadzu Nexera X2Shimadzu Nexera X3Thermo Scientific Q ExactiveMultiple MyelomaShimadzu Nexera X16MetabolomicsShimadzu Nexera X15Shimadzu Nexera X17untargeted analysisShimadzu Nexera X8cell culture supernatantShimadzu Nexera X9Homo sapiensShimadzu Nexera X10Shimadzu Nexera X4Shimadzu Nexera X12Shimadzu Nexera X5Shimadzu Nexera X11pooled sampleShimadzu Nexera X6Shimadzu Nexera X14untargeted metabolite profilingShimadzu Nexera X7Shimadzu Nexera X13Shimadzu Nexera X2Shimadzu Nexera X3Thermo Scientific Q ExactiveMultiple MyelomaEach sample was analyzed using electrospray ionization (ESI) in both positive (+) and negative (−) ion modes. After UPLC separation, mass spectrometry analysis was performed using a QE Plus mass spectrometer (Thermo Scientific) equipped with a HESI source. The ionization conditions were as follows: Spray Voltage: 3.8 kV (+) and 3.2 kV (−); Capillary Temperature: 320 °C; Sheath Gas: 30 arbitrary units; Aux Gas: 5 arbitrary units; Probe Heater Temperature: 350 °C; S-Lens RF Level: 50.The MS acquisition settings were as follows:Total MS acquisition time: 15 min. MS1 scan range: 75–1050 m/z; MS1 resolution: 70,000 @ m/z 200; AGC target: 3e6; Maximum IT (MS1): 100 ms. MS2 analysis was performed as follows: after each full scan, ten MS2 spectra were triggered for the top ten most intense precursor ions. MS2 resolution: 17,500 @ m/z 200; AGC target: 1e5; Maximum IT (MS2): 50 ms; MS2 activation type: HCD; Isolation window: 2 m/z; Normalized collision energy (stepped): 20, 30, 40.D-LeucineN-Fructosyl isoleucineButyric acidN-AcetyldopaminePC(16:0/18:2)Guaiacol2-Methyl-4-oxopentanedioic acid(7E)-3-Isobutyl-13-methoxy-4,5,8-trimethyl-3,3a,4,6a,9,10,11,12,13,14-decahydro-1H-cycloundeca[d]isoindole-1,15(2H)-dionePE(16:0/20:4)PseudoanisatinReserpineFolic Acid6-AminoindazoleN-Desmethylrosiglitazone1,5-NaphthalenediamineAmphetamine2-Ethyl-1-hexanol sulfateN-MethylisoleucineN-{2-[4-(N,N-diethylcarbamoyl)-2-methoxyphenoxy]ethyl}acetamide4-HydroxybenzaldehydeAcetamide, N-(3-amino-4-methoxyphenyl)-CyclopentylamineDehydrohistidyltryptophyldiketopiperazineCyclohexylamine1,3-dimethoxy-10,10,10a-trimethyl-6,7,10a-trihydro-1,3-oxazolidino[4,3-a]phtha lazine-5,8-dioneLauryl DiethanolamideN-cyclopentyl-2-{4-[(6-ethoxy-2-oxochromen-4-yl)methyl]piperazinyl}acetamide2-(4-oxoquinazolin-3(4H)-yl)ethyl isobutyrate4-hydroxy-3-phenyl-6-(phenylmethoxy)hydroquinolin-2-oneRoquefortine EPilocarpineCyclododecalactam10,11-Dihydroxycarbamazepine3-methylpyrazolyl 3,4,5-trimethoxyphenyl ketonecis-3-Hexenyl lactate2'-O-MethylguanosineArginineGangaleoidinFusaric acid(6R,8Z)-6-Hydroxy-3-oxotetradecenoic acid3,6-Diphenylcyclohexan-1,2-diol2,8-DihydroxyquinolineObtucarbamate AFMNN-[1-(4-methoxy-6-oxopyran-2-yl)-2-methylbutyl]acetamideCaffeic acid8-Methyl-IQXPC(16:0/18:1)4-Amino-5-hydroxymethyl-2-methylpyrimidineSalicylamideMethylergonovineIsotretinoinLidocaine3-Hydroxydodecanedioic acid2-Cyclopenten-1-onePantothenic acidEudesmin3-Methylazelaic acidGlutamylphenylalaninePI(18:0/18:2)Malonic semialdehydeL-Ornithine3-butyl-4-hydroxy-1-phenylhydroquinolin-2-onebatatasin IIIQuinolinolSaccharinDiphenyl phosphatePipemidic acidMetalaxylPhenylephrineVanillic acidMonoisobutyl phthalateAcetoacetic acidOctaethylene glycolPongamolRhodiocyanoside ABenzoxazineXanthyletinAminoadipic acid3-Hydroxymyristic Acid4-Methylphthalic anhydrideHomoarecolineLasiocarpine N-oxide4-Deoxyerythronic acidSM(d16:1/16:0)Dimethyl 5-sulphoisophthalate2-Isopropyl-6-methyl-4-pyrimidonePyridine4-HydroxyquinolineAnisoleNoroxyhydrastinineMethyl 2-HydroxyisobutyratePC(18:3/18:3)OrnithineLPC(18:2)3-MethyladenineD-GlucoseIndoleProstaglandin A1PhenylsulfateFuranone ACyclo(Pro-Leu)IsoleucylaspartateN-LauroylglycineLPC(18:1)FraxetinPS(18:0/18:1)N-(3,4-Dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamideMethylthiopropene(S)-7-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)-2-oxoethoxy)-2-methyl-3-phenyl-4H-chromen-4-onePIPES(R)-2-Hydroxycaprylic acid2-Hydroxycinnamic acid2-oxo-1H,2H,5H,6H,7H-cyclopenta[b]pyridine-3-carbonitrile3-Hydroxytetradecanedioic acidPrecocene IIStearic acid amide(S)-ActinidineMatairesinolSalsolinol-1-carboxylic acid1-Hydroxy-2-butanoneLPC(18:0)3-Hydroxybutyric acid4-methyl-N-(((1S,9aR)-octahydro-1H-quinolizin-1-yl)methyl)-2-phenylthiazole-5-carboxamideAscorbic acid2-Hydroxy-4-Methoxychalcone3-Hydroxycapric acidLathyrol5-MethylcytosineMethylsuccinic acid6-MethylpurineTetradecanedioic acid2-[4-(N,N-diethylcarbamoyl)-2-oxohydroquinolyl]-N-(2,4-difluorophenyl)acetamid ePC(16:0/16:0)Isoxanthohumol(S)-10,16-Dihydroxyhexadecanoic acidArginylphenylalanine1H-Pyrrole-2-carboxaldehydeMono-(2-ethylhexyl)phthalateThreonine5,6-Dihydro-1,10-phenanthrolineN-[4-[(9S,13R)-16-hydroxy-7,9,13-trimethyl-5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-6,18-dien-6-yl]-2-methylbutyl]acetamideN-UndecanoylglycineL,L-Cyclo(prolylalanyl)NorclozapineLysineAcetaminophenAlanine betaineBakers yeast extractgamma-delta-Dioxovaleric acidTrehaloseSuccinic anhydrideUmbelliferone8-Hydroxyoctanoic acid1,3-Dimethylpyrrolo[1,2-a]pyrazine(Z)-2-((Z)-1-(hydroxyimino)ethyl)-6,6-dimethylbicyclo[3.1.0]hexan-3-one oxime4-Aminophenylacetic acid1-MethylnicotinamideN'-[(1E)-2-(3,4,5-trimethoxyphenyl)-1-azavinyl]-N-(2-methylphenyl)butane-1,4-d iamide2-(methylethylidene)butanedioic acidEnt-Junceic AcidAcetanilidecis-4-Octenedioic acidXanthosinedGMPCitraconic anhydrideCitric acid3-Hydroxy-N-(2-oxotetrahydrofuran-3-yl)octanamideSM(d18:0/18:1)3-{N-[2-(4-methoxyphenyl)acetylamino]carbamoyl}propanoic acid2-MethylpyridineN-Acetyl-L-arginine3-(2-Oxoazepan-1-yl)propanoic acid3-Hydroxybenzyl alcoholPlatifillinEicosatetraenoic acidBenzeneacetonitrile1H-indole-3-carboxamideMethylthioadenosinePipecolic acidIndole-3-acrylic acidN-(1-hydroxy-3-methylbutan-2-yl)-2-((4-oxo-3-phenyl-4H-chromen-7-yl)oxy)acetamideAaptamineLPC(16:1)SakuranetinPE(18:0/22:6)Bis(2-methoxyethyl) phthalateWarfarinLeucyl-Isoleucine1,3-Benzodioxole-5,6-diamine2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-amineHelicide5-Hydroxymaltol5-hydroxycalameneneSM(d18:0/16:1)(S)-3-Hydroxybutyric acidAustinoneol2-(Fluoromethyl)-3-(3,4-dihydroxyphenyl)alanineLumiflavinBenzofuran2-Propenyl cyclohexanebutanoateMethyl acrylate2-HydroxyquinoxalineLPC(16:0)PE(18:0/22:4)JaranolVanillyl alcohol1,2-Dihydroquinoline3',4'-Dihydroxy-.alpha.-naphthoflavone1,5-Anhydrosorbitol3-methoxy-4-(2-oxo-2-piperidylethoxy)benzaldehydeMyoinositol2-(4-methyl-6-(2-naphthyloxy)pyrimidin-2-ylthio)-1-phenylethan-1-oneSkimmianineProtoanemonin6-n-PropyluracilTriptophenolide2,5-Dihydro-2,4,5-trimethyloxazole6-[(Propan-2-yl)oxy]pyridine-3-carboxylic acidO-AdipoylcarnitineN-Acetylasparagineethyl 2-[2-(1,3,7-trimethyl-2,6-dioxo-1,3,7-trihydropurin-8-ylthio)benzimidazo lyl]acetate2-Hydroxyglutaric acid2-(4-Methylphenyl)chromen-4-one1-Methyladenosine1-(2-Hydroxyethyl)-2,2,6,6-tetramethyl-4-hydroxypiperidineAcetylleucine (isomer of 164)9,10-DiHOME2-(1-hydroxy-1-methoxy-3-methylbutyl)-6-methyl-5H-[1,3]dioxolo[4,5-c]pyridin-4-onePE(18:0/22:5)ZinniolPS(18:0/22:6)Creatine riboside2,5-Dihydro-1H-pyrrole-2-carboxylic acidTridecanoylglycinePC(18:1/14:0)PirbuterolTrifluoroacetic acid1-CarboxyethylvalineTridecanedioic acid8-Amino-7-oxononanoic acid9,10-Epoxyoctadecanoic acidPyridoxalTrigonellineSM(d18:1/18:1(9Z))2-(4-Methoxy-benzoylamino)-4-methyl-pentanoic acidN-NonanoylglycineButenylcarnitine1,2,3,4,Tetrahydro-1,5,7-trimethylnapthalene2-(4-hydroxyquinazolin-2-ylthio)-1-(2-methylpiperidyl)ethan-1-one2-Naphthalenesulfonic acid16-Hydroxy-10-oxohexadecanoic acidDibenz(a,j)acridineTetrahydropalmatine2-Phenylethyl beta-D-glucopyranosidegamma-Guanidinobutyric acid(E)-5-(3,4,5,6-Tetrahydro-3-pyridylidenemethyl)-2-furanmethanol4-EthylanilineN-Hydroxy-1-aminonaphthaleneGlycocyamineN-(4-butylphenyl)(3,4,5-trimethoxyphenyl)carboxamidePhenylalanineRanitidine S-oxidePC(16:0/22:6)CholesterolGentiatibetinemethyl 2-(8-methyl-3a,4,5,6-tetrahydro-1H-pyrazino[3,2,1-jk]carbazol-3(2H)-yl)acetateMorpholineTenuazonic acidL-alpha-Amino-1H-pyrrole-1-hexanoic acid[3H]Rosiglitazonemethyl 2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)propanoate2-Hydroxyhexadecanoic acid3-Hydroxy-2H-pyran-2-oneUracilEpijasminoside APE(18:0/20:4)Difloxacinalpha-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanolmethyl 2-[(5,6,7-trimethoxy-3-oxohydroisobenzofuran-4-yl)methylthio]benzoateApitolisib4-Oxo-L-prolineCreatineN-(2-Hydroxyethyl)nicotinamideOctopineIsoplumbagin4-HydroxymandelonitrileSimazineEuparinPhenylglycineBenzothiazoloneIndole-3-acetyl-glutamic acidKobusone1,3,5-HexatrienePS(18:0/22:4)4-Amino-2-hydroxy-5-[[1-hydroxy-1-(2-oxo-1-bicyclo[4.1.0]hept-3-enyl)propan-2-yl]amino]-5-oxopentanoic acidThermopsineMethyl 2-[(2-hydroxy-3-methylbutanoyl)amino]-3-methylbutanoateN-lactoyl-Tyrosine3,6,9,12,15,18,21,24,27-Nonaoxanonacosane-1,29-diolHomovanillic acidTriptolide2-Phenylpyridine3-Hydroxyoctadecanoic Acid2-Hydroxy-4-imino-2,5-cyclohexadienoneO-Desmethyl tramadolIndole-3-Lactic AcidAcedobenIsoleucinePantoyl lactone glucosideXanthone3-Hydroxy-5Z-octenyl acetatePE(18:0/20:3)2,3-Diaminotoluene2-Methylhippuric acidCanrenonePS(18:0/22:5)2-[4-(sulfooxy)phenyl]acetic acid1,2,4-Triazin-5(2H)-one, 6-(1,1-dimethylethyl)-3-(methylthio)-VestitolNiflumic acid2-Hydroxy-3-(2-hydroxyphenyl)propanoic acidHEPESDoxycyclinePantothenic acid (Not validated)PC(18:0/20:4)NorepinephrineArabinosylhypoxanthineGlutaminePS(18:0/20:4)Phenylacetic acid4-[4-(2-Chlorophenyl)piperazin-1-yl]-4-oxobutanoic acidMyristoylglycine4,5-DihydrovomifoliolTyrosylisoleucine(1S,2R,4aR,8aR)-1-Acetoxy-7-isopropylidene-1,4a-dimethyl-6-oxodecahydro-2-naphthalenyl 2,3-dimethyl-2-oxiranecarboxylateHistidinemethyl 7-(4-chlorophenyl)-4-(4-hydroxy-3-methoxyphenyl)-2-methyl-5-oxo-1,4,6,7 ,8-pentahydroquinoline-3-carboxylate3-Hydroxycarbofuran3,4-dimethoxyphenyl 4-(3-chlorophenyl)piperazinyl ketoneGraveolide4-Hydroxy-3-benzylcoumarin4-Hydroxy-2H-pyran-3-carboxaldehydePhosphoric acidBerberineN-Benzyl-4-((3-Oxo-3-(2-Oxo-2H-Chromen-3-Yl)Propyl)Amino)BenzamideErysubin FMyristamine OxideCadabicilone2H-benzo[3,4-d]1,3-dioxolen-5-yl-N-(4,5,6,7-tetrahydrobenzothiazol-2-yl)carbox amideNalidixic acidIndole-3-carboxyaldehydeFA 9:0 + 1O, sulfateGlycerophosphocholine1(2H)-Naphthalenone, 3,4-dihydro-2-((4-methoxyphenyl)methylene)-, (E)-[4-(difluoromethoxy)-3-ethoxyphenyl]-N-(1-methylpyrazol-3-yl)carboxamide1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid2-Ethylaniline1-acetyl-3-{[2-(ethylpropyl)quinazolin-4-yl]amino}benzene1-Dodecyl-2-pyrrolidinonePC(16:0/20:5)N-(3,4-dimethoxyphenethyl)-1H-indole-3-carboxamidePC(O-16:0/18:1)Hydroxymethyl indol-3-yl ketone12-Hydroxy-6-Epi-Albrassitriol3-(2-(2H,3H-benzo[3,4-e]1,4-dioxin-6-yl)-2-oxoethyl)-3-hydroquinazolin-4-oneN-AcetylputrescineTryptophanMagnololXanthineDL-Cycloserine3h-Indole-3-propanoic acid,a-amino-2-[[(2R)-2-dodeca-4,7,10-trienoyloxy-3-hexadecoxypropoxy]-hydroxyphosphoryl]oxyethyl-trimethylazaniumCholineHomoprolineOxypeucedanin Hydrate2,3,6-Trichloro-5-cyano-4-hydroxybenzamide4-Hydroxy-N-methylcarbostyril2-Chloro-1-methylpyridinium iodide2,6-Di-tert-butyl-4-nitrophenolNicotinic acidPG(16:0/18:1)2-Isopropyl-5-methylpyrazineVitispirane2-hydroxyacrylic AcidDOPAN,N-Dimethyl-N'-Phenylsulfamide(Z)-13-Oxo-9-octadecenoic acid2-AminopurineCyclo(L-Isoleucyl-L-Isoleucyl)Undecanedioic acidCorydalineS-AdenosylhomocysteineDimethyl sulfoxideAcridine2-(3,4-dimethoxyphenyl)-6,8-dimethylchromen-4-one4-hydroxy-4-(pyridin-2-yl)butan-2-onePhthalic anhydrideLeucineN-(3-bromophenyl)-2-[4-(morpholin-4-ylcarbonyl)-2-oxohydroquinolyl]acetamide(R)-alpha-MethylhistamineCitramalic acidBis(3-Allyl-4-Hydroxyphenyl)Sulfone(7,8-dimethoxy-2,2,3-trimethyl-2,3-dihydro-1H-benzo[d]azepin-4-yl)(3,4-dimethoxyphenyl)methanonep-Aminobenzoic acid5-Pentyl-2-furanheptanoic acid2-Hydroxymyristic acidPS(18:0/20:3)3,5-Dihydroxy-4-[3,4,5-trihydroxy-6-[[4-(2-hydroxypropan-2-yl)cyclohexene-1-carbonyl]oxymethyl]oxan-2-yl]oxybenzoic acidPE(P-18:0/20:4)Isobavachinp-Coumaric acid2-Acetyl-1,5,6,7-tetrahydro-6-hydroxy-7-(hydroxymethyl)-4H-azepine-4-oneFA 9:2+1O2-Pentanamido-3-phenylpropanoic acidPhosphocholine4H-1-Benzopyran-4-one, 6-methyl-2-(2-methylphenyl)-o-Dodecylbenzenesulfonic acidPharmaGSID_473337-Amino-4-methylcoumarin2-CyanoacetamideNA-135Isoeugenyl acetate(2Z)-2-benzoxazol-2-yl-3-(4-hydroxy-3-methoxyphenyl)-1-(4-methylphenyl)prop-2- en-1-onealpha-IroneLPC(20:4)(10betaH,11xi)-11-Hydroxy-13-nor-6-eremophilen-8-onePG(18:0/18:1)N-IsovaleroylglycineRiboflavinLauramidopropylbetaineFolic acidMebendazole7-[(2-fluorophenyl)methoxy]-4-methylchromen-2-one6,10a-Dihydroxy-4-(hydroxymethyl)-4,7,11b-trimethyl-1,2,3,4a,5,6,6a,7,11,11a-decahydronaphtho[2,1-][1]benzouran-9-oneSuccinoadenosineQuinolineAlibendolm-Aminobenzoic acidPE(18:1/20:4)VasicinoneLauryl Ether SulphateOctadecenedioic acidethyl 10-[2-(3,4-dimethoxyphenyl)ethyl]-2,4-dioxo-3,10-dihydrobenzo[g]pteridin e-8-carboxylateBiotinGMP4-[Formyl(6-Methoxyquinolin-8-Yl)Amino]Pentanoic Acid4-[(4-chlorophenyl)methyl]-7-hydroxy-3-phenylchromen-2-oneNeotrehalosePhenol2-FuranmethanolNeomycinPI(18:0/20:3)2-Propenoic acid, 2-(hydroxymethyl)-, (1aR,5aR,8aR,9S,10aR,11R)-1a,2,5a,7,8,8a,9,10-octahydro-11-hydroxy-8-methylene-7-oxo-3H-4,10a-(methanooxymethano)oxireno[5,6]cyclodeca[1,2-b]furan-9-yl esterThiazoleLeucinic acidMyclobutanilCalystegine A6Dicyclohexylamine1,7-Diphenyl-5-hydroxy-1-heptene-3-oneCinnamic acidPC(18:1/18:2)Triethylene glycol monomethyl ether3,4-dimethyl-9-phenyl-7H-furo[2,3-f]chromen-7-one4-(2-Furanylmethylene)-3,4-dihydro-2H-pyrrole2,2,6,6-Tetramethyl-4-piperidinolLPE(18:0)3-(2-chlorophenyl)-7-hydroxychromen-2-oneGlutaric acid9,10,13-TriHOMEPI(18:0/20:4)MagnocurarineRisedronate Sodium2-Methoxy-3,4-dimethylphenyl acetate1-PiperidinecarboxaldehydeLignocaine N-oxide(2E)-3-(1H-Indol-2-Yl)Prop-2-Enoic AcidN,N-Diethyl-4-Hydroxybenzamide3',5'-Dideoxythymidine3'-GMP3-(2-Furanyl)-2-propenal2-(3-(8-hydroxyoctyl)phenoxy)-2-methylpropanoic acid5-[5-Hydroxy-3-(hydroxymethyl)pentyl]-8a-(hydroxymethyl)-5,6-dimethyl-3,4,4a,6,7,8-hexahydronaphthalene-1-carboxylic acidPC(17:0/16:1)-D5N-(2,4-dioxo(1,3-dihydropyrimidin-5-yl))-2-phenoxypropanamideCyanazinePC(16:0/P-16:0)PE(18:1/20:1)2-(4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-pyrazol-5-yl)-4-ethyl-5-methoxyphenolHemineurinegamma-GlutamylisoleucinePratolKetoprofen1,3,6-Trihydroxy-2-(3-methylbut-2-enyl)xanthen-9-onePseudouridine 5'-phosphate8-Acetamido-2-methyl-7-oxononanoic acid5-Butyl-2-methylpyridinePA(16:0/18:1)Triacanthine1-Aminocyclopentane-1,3-Dicarboxylic AcidPiconolMelilotic acid3-Buten-2-one, 4-[4-(beta-D-glucopyranosyloxy)-2-hydroxy-2,6,6-trimethylcyclohexylidene]-MemantineSulfamethazine4-methylquinoline-2-carboxylic acid(S)-3-(4-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)-2-oxoethoxy)phenyl)-8-methoxy-2H-chromen-2-oneCyproconazoleImazamox1,2,3,4-Tetrahydroquinoxaline1-CarboxyethylphenylalanineViridicatol5-Dihydroxyhept-6-enoic acidIsophthalic acidProlineDeferiproneAnisic acidHuperzine ALPC(22:4)Tetrahydropyridine3-Hydroxymethylglutaric acidCitromycetinepsilon-Maleimido-lysineIsoindolineCerulenin1-Palmitoyl-2-thiopalmitoyl phosphatidylcholineThiamineCapric dimethyl amine oxideIndole-3-acetic acidNorhygrineSuberylglycineTetradecyldiethanolamine10,11-dihydro-20-dihydroxy-LTB4LPC(22:5)Butyl 4-aminobenzoate(Z)-5-[(2R,3S,4S)-4-Hydroxy-2-[(E)-3-hydroxyoct-1-enyl]oxan-3-yl]pent-3-enoic acidFumaric acid6b-Hydroxy-8a-methoxy-7(11)-eremophilen-12,8-olide1-(3-carboxypropyl)-3,7-dimethylxanthineMyrsinoneN-LactoylvalineKaurenic acidDocosa-2,4,6,8-tetraenoic acidHydroxysuberic acidPC(16:0/P-18:1)AurapteneCloropheneMicrominutinAcoric acidethyl 4-hydroxy-3-methyl-2-oxohydroquinoline-6-carboxylateMurracarpinphenylmethyl 1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]pyrrolidine-2-carboxylateTrachelanthineLPE(16:0)LPC(22:6)Atractylenolide IIPyrroline hydroxycarboxylatePI(18:0/22:4)6-methoxyflindersineSpermidineIndole-5,6-quinoneMethoxyacetic acidSissotrine3-hydroxy-N-(2-oxooxolan-3-yl)tetradecanamide2-Methyl-2-phenylsuccinimide2-Isopropylmalic acidLinderalactoneN,N'-DiphenylguanidinePC(20:5/16:0)1-Methyl-1,2-dihydropyridine-3-carboxamidePE(22:6/18:0)2H-benzo[d]1,3-dioxolan-5-yl-N-(4,5-dimethyl(1,3-thiazol-2-yl))carboxamideFlavokawain AAcetone cyanohydrin3-Phenylacetylamino-2,6-piperidinedioneGlutamic acid5-butyl-3-methyl-7H-furo[3,2-g]chromen-7-onePsicose20-Hydroxy-PGF2a4-FormylaminoantipyrineSuberic acidHydroxyproline1H-Imidazole-4-carboxamideZearalenone4-Nitrophenol6-EthylthiopurinePiperine3-Phenyl-3-(pyridin-2-yl)propanoic acidPE(16:0/18:1)2,3,4,9-Tetrahydro-6-methoxy-1H-pyrido(3,4-b)indol-1-oneRitalinic acidMasoprocolPC(18:1/16:0)2-HydroxypyridineQuetiapine(3R,3aR,7aS)-3-Butylhexahydro-1(3H)-isobenzofuranoneCreatinineTyrosylprolineTranscrocetinate sodium4-Vinylcyclohexene2H-BenzotriazolePyridoxine1-O-Hexadecyl-sn-glycero-3-phosphocholinePE(P-16:0/20:4)Carbazole5-Hydroxyhexadecanoic acidDi-N-propylamine3-Methylquercetinbeta-carbolineDihydrobiopterin3-Methylene-indolenineTheobromineS-(2-Carboxypropyl)glutathionePregabalin5-[(1-Iminoethyl)amino]-2-aminopentanoic acid2-oxo-Butanal1-Hydroxy-2,2,6,6-tetramethyl-4-piperidinone4-OctylphenolDihydroartemisinin (DHA)Betaine5-Oxooctadecanoic acidNeoline4-Quinolinecarboxylate1-Aminocyclopropane-1-carboxylic acidAMPN-Lauroyl Alanine3-Phenyllactic acidPC(18:0/18:2)7-(1,6-dihydroxy-3-methyl-5-(methylethyl)-8-{[(2-methylphenyl)amino]methylene} -7-oxo(2-naphthyl))-3,8-dihydroxy-6-methyl-4-(methylethyl)-1-{[(2-methylphenyl )amino]methylene}naphthalen-2-onePE(16:0/18:2)Homostachydrine5,6-Dihydroxy-2-methylaminotetralinO-SuccinylhomoserinePC(17:0/14:1)-d52-Methyl-5-nitrobenzenesulfonic acid3-Hydroxyisovaleric acidPG(20:4/18:0)6-hydroxyoct-1-enoylglycineIsoprenyl alcoholHydrocotarnineSchembl125490916-bromo-2-(2-methylphenyl)chromen-4-one1-PyrrolidinecarboxaldehydeAmitriptylineTriphenylphosphine oxideHyodeoxycholic acid1H-Indene-1,2(3H)-dione2-AminoanthraquinoneImidazooxazole2-Hydroxybenzonitrile3-EthylpyridineSM(d18:2/16:0)Dictyoquinazol ADictyoquinazol CRutecarpine3-hydroxy-3-(3-hydroxyphenyl)propanoic acid-O-sulphate2-Methylthioadenosinemethyl 2-{2-methoxy-4-[(3,4,5-trimethoxyphenyl)carbonylamino]phenoxy}acetate5-HydroxytryptophanKynurenic acidN-FormylmethionineHarmol HydrochlorideMethionineCepharanthine4-Anilino-4-oxobutanoic acidN-(3,4-dimethylphenyl)(2-iminochromen-3-yl)carboxamide3-Ethylfuran2-(4-oxo-1,2,3,5-tetrahydrocyclopenta[1,2-c]quinolin-5-yl)acetic acidStyreneBromacil2,4-DihydroxypyridineGallic acid methyl esterNonaethylene glycolCitrininBenzyladenineLauryldiethanolamine2,5-PiperazinedioneCupressic acidMmv688469SotalolPC(18:2/18:2)p-Coumaraldehyde4-hydroxy-1-phenyl-3-benzylhydroquinolin-2-one4-Acetoxy-2-hexyltetrahydrofuranKaempferolKojic acid2-{4-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-enyl]phenoxy}acetamidePhenylacetylglycine(4E)-7-Acetoxy-6-hydroxy-2-methyl-10-oxo-3,6,7,8,9,10-hexahydro-2H-oxecin-3-yl (2E)-2-butenoateOsthole2-Imino-N-(4-Methylphenyl)-2H-Chromene-3-CarboxamidePE(18:1/16:0)PC(O-16:0/20:5)PC(20:4/20:4)1-Piperideine-2-carboxylic acidTschimganidin(6-chloro-2-iminochromen-3-yl)-N-(4-ethylphenyl)carboxamideO-ArachidonoylglycidolPC(16:1/16:1)Phytosphingosine2,4-DichlorophenolN-(2-chlorophenyl)-2-[2-oxo-4-(piperidylcarbonyl)hydroquinolyl]acetamideOryzalinGelomulide NValerenic acidTyrosinePS(18:1/18:0)9,10-Dihydroxystearic acid3-Ureidopropionic acid5-Methylpyrazine-2-carboxylic AcidLauramine oxide4-Methylimidazole(6,6-Dimethylbicyclo[3.1.1]hept-2-yl)methyl 6-O-[(2R,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-beta-D-glucopyranosideArabitolMaoecrystal ASuccinic acidHypoxanthinePS(18:1/18:1)3-HydroxymonoethylglycinexylidideN-(3-Oxododecanoyl)-L-homoserine lactonePE(16:1/20:4)HomoserineMelilotin4,7,8-Trimethoxy-3,5-dimethylchromen-2-oneHippuric acidBenzothiazole(2-Amino-4-Methyl-6-Oxo-1,6-Dihydropyrimidin-5-Yl)Acetic Acid4-Deoxypyridoxine2-Methylbenzaldehyde7-Ethyl-2,3,6,7-tetrahydrocyclopent[b]azepin-8(1H)-oneTaxifolin 7-rhamnosideCycluronGallacetophenone1-CarboxyethylleucineN-Butyrylhomoserine lactoneOxysophocarpine5-Hexyl-3-methyl-2-furannonanoic acid4-(Dimethylamino)benzoic acidCocaineDidanosineLumichromePE(18:1/18:1)Carbapenem3-Hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-onem-ToluamideVitamin B12N-AcetylmethionineMelibiose2,6-Diamino-9-(2-hydroxyethoxymethyl)purineAcetylleucineCaffeine4-HydroxybenzoylcholineQuinaldineN-Acetylproline2-Methylglutarate3-Hydroxybenzoate2,5-Dihydropyrimidine8-Methylquinoline2H-1-Benzopyran-2-one, 7-(ethylamino)-4-methyl-PC(14:0/14:0)N-LactoylleucineCyclo(Pro-Val)alpha-Methylene butyrolactone2-Hydroxyvaleric acid3,4-DihydroxybenzylamineLevosulpiride3-Butylphthalic acidPE(18:0/18:2)ProtopanaxatriolSulisobenzonePyroglutamic acidAstragalinChavicolPE(18:1/18:2)HigenamineSuccinylcarnitinePE(16:0/22:5)Dodecanedioic acid(3E,5Z)-1,3,5-Heptatriene4-Hydroxybenzotriazole8alpha-8-Hydroxy-12-oxo-13-abieten-18-oic acidFluometuron6-Amino-1,2-benzopyrone3-Hydroxyhexadecanoic acidDimethyl myristamineDodecyl sulfate4-methyl-2-oxochromen-7-yl 3-chlorobenzoateAcetylcholinePG(16:0/20:2)N-DecanoylglycineTanshinone IIAValerylcarnitineIsoleucylphenylalanine5-(6-methyl-7-oxooctyl)furan-2(5H)-one3-Methylpimelic acidN-Lauroylsarcosine1-Ethyl-1H-pyrrole-2-carboxaldehydeFlunixin2-Methyl-4(3H)-quinazolinoneTerbutaline2-Methyl-3-oxopropanoic acidPC(O-18:1/20:4)Methylmalonic acidMalic acidCotininePC(14:0/16:0)N-[1-(2-Methylbenzyl)-1H-Pyrazol-4-Yl]-3,4-Dihydroisoquinoline-2(1H)-Carbothioamide3-ethyl-4-hydroxy-1-benzylhydroquinolin-2-one4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentan-2-yl (E)-3-(4-hydroxyphenyl)prop-2-enoateAnhydroecgonineVitamin K1m-Coumaric acidErucamideErythronolactoneFA 18:4;O6,7-Dimethoxyquinazoline-2,4(1H,3H)-dioneDocusate hydrogenHistamineN-Acetyltyrosineethyl 3-{N-[4-(ethoxycarbonyl)phenyl]carbamoyl}propanoateTraumatin3-Aminopicolinaldehyde6-Dimethylaminopurine2-Benzimidazolecarbamic acid3,5-DihydroxyphenylglycinePC(14:0/16:1)LPC(20:2)1,3-DicyclohexylureaHexadecanamidealpha-Naphthoflavone3-Oxotetradecanoic acidAzelaic acidp-ToluenesulfonamideProstaglandin F2bSebuthylazine7-Benzofurancarboxylic acid, 2,3-dihydro-2-(1-hydroxy-1-methylethyl)-4-methoxy-6-(2-phenylethyl)-(R)-3-Hydroxydodecanoic acid2-Methyl-1,4-benzoquinone6-Methyl-2-pyridinecarboxylic acid3'-AMP5-HydroxyindoleacetateClozapineImazethapyrNorvaline3-Oxohexadecanoic acidfalseAdipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma by stabilizing IRF4 via NAT10-mediated acetylation Multiple myeloma (MM) remains an incurable hematologic malignancy despite advances in treatment. While obesity is a well-established risk factor, the underlying metabolic mechanisms by which adipocytes contribute to disease progression remain elusive. Here, we uncover a critical metabolic crosstalk between adipocytes and MM cells that promotes MM cell survival under glucose deprivation. We show that glucose restriction activates AMPK, leading to subcellular relocalization of HSP90 and disruption of its protective interaction with the oncoprotein IRF4, thereby rendering IRF4 susceptible to TRIM21-mediated ubiquitination and proteasomal degradation. Paradoxically, the same metabolic stress stimulates adipocytes to upregulate ketogenesis and produce β-hydroxybutyrate (β-OHB). MM cells utilize β-OHB via OXCT1-mediated ketolysis, fueling NAT10-dependent acetylation of IRF4 at K87. This acetylation event restores IRF4-HSP90 binding, thereby shielding IRF4 from degradation and sustaining tumor cell survival. Genetic ablation of Hmgcs2, the rate-limiting ketogenic enzyme, in adipocytes abrogates this protective effect. Importantly, combining an AMPK activator (metformin) with either an OXCT1 inhibitor (pimozide) or a NAT10 inhibitor (remodelin) results in potent synergistic antitumor activity in vivo. Our study thus positions β-OHB as a critical metabolic adaptor that empowers myeloma cells to circumvent glucose metabolic stress and highlights a promising combination therapeutic strategy that exploits the vulnerability arising from competing metabolic dependencies.2026-05-072026-05-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